{"data":[{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":64,"idioma_id":5,"titulo":"El impacto de la Asignación Universal por Hijo para la Protección Social en las instituciones escolares de Mendoza","resumen":"-","palabras_clave":"Asignación Universal por Hijo|Protección Social|Instituciones escolares"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":133,"idioma_id":5,"titulo":"Terapia metacognitiva. El sindrome cognitivo-atencional y los procesos cognitivos","resumen":"El artículo explora los elementos centrales del modelo metacognitivo de los trastornos mentales. Se analiza el rol de los pensamientos automáticos en los principales trastornos de ansiedad y depresivos. Se describen los procesos cognitivos que privilegia el modelo metacognitivo: la rumiación, la preocupación,&nbsp; y la atención selectiva en la amenaza. Se define la metacognición: conocimiento y experiencias. Se describe el síndrome cognitivo-atencional y sus componentes. Se caracteriza la atención plena (mindfulness) desapegada y se la diferencia de otras formas y usos de la misma. Se discuten las diferencias y semejanzas entre el modelo metacognitivo y el modelo cognitivo estándar. Se reseñan los principios del modelo según Adrian Wells. Se concluye acerca de su relevancia en el contexto clínico actual.&nbsp; ","palabras_clave":"Terapia metacognitiva|terapia cognitiva|metacognición|trastornos mentales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":141,"idioma_id":5,"titulo":"Estrategias productivas y resultados económicos en la horticultura marplatense entre 1993-2012: un análisis de insumo producto","resumen":"La presente investigación tiene como objetivo describir y evaluar los cambios en los resultados económicos y productivos generados por la crisis económica de 2001 y la caída de la convertibilidad en los cultivos tradicionales del cinturón hortícola marplatense. El período de análisis es 1993?2012. Se identifican en este período los componentes del costo de producción de los cinco cultivos más relevantes de la zona; se explican los cambios productivos implementados, analizando las modificaciones en el peso relativo de los diferentes componentes del costo; y se compara la evolución de los resultados económicos obtenidos con la de los precios de los insumos y de los coeficientes insumo?producto.","palabras_clave":"HORTICULTURA INTENSIVA|VALOR AGREGADO|CRISIS ECONÓMICA|GENERAL PUEYRREDON"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":177,"idioma_id":5,"titulo":"El rol de la institucionalidad pública en procesos autogestionarios de viviendas en Argentina","resumen":"Este artículo analiza la relación entre las organizaciones sociales adjudicatarias de las viviendas y las distintas gestiones de gobiernos que se hicieron cargo de la implementación del Programa de Autogestión para la Vivienda (PAV) en la Ciudad de Buenos Aires (Argentina). Aún con limitantes y limitaciones, las experiencias sociales y colectivas asociadas al diseño e implementación del PAV contribuyeron a la construcción de un significativo campo de disputa por la democratización de la producción de ciudad y la apropiación de la centralidad urbana, reivindicando para los sectores de menores recursos el derecho a la ciudad y al hábitat.","palabras_clave":"Estado|Autogestión de vivienda|Producción Social del Hábitat|Participación Social"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":191,"idioma_id":5,"titulo":"LA CULTURA INSTITUCIONAL EN EL ESCENARIO ACTUAL: LA COMPRENSIÓN LECTORA COMO EXPERIENCIA EDUCATIVA INTERÁREAS","resumen":"El presente trabajo tiene por objeto socializar una experiencia llevada a cabo a través de un encuentro docente, bajo la modalidad de Taller, en una Escuela Secundaria de la ciudad de San Luis. Cabe aclarar que dicho encuentro se realizó por expreso pedido del equipo directivo y los profesores de Nivel Medio, y estuvo destinado al abordaje de la comprensión lectora que atañe a todas las áreas disciplinares, por lo que se parte de la premisa de que debe tratarse como un contenido transversal.Para la organización se contó con el aval de la Facultad de Ciencias Humanas de la Universidad Nacional de San Luis, a través del Proyecto de Extensión ?Intercambio y Formación entre Universidad e Instituciones Educativas: la formación de formadores como responsabilidad conjunta?. La importancia de un Taller de este tipo radica en que genera una instancia de reflexión y debate que propicia el intercambio entre los docentes co-formadores, a los fines de detectar las problemáticas recurrentes que afectan a la comprensión lectora, en este caso de los alumnos de Educación Secundaria, y obstaculizan el buen desempeño académico y la futura inserción en instituciones de Nivel Superior. En suma, se apunta a poner en común y sistematizar algunos puntos centrales derivados del Aula Taller y se invita a pensar\/repensar, con un sentido crítico y reflexivo, en propuestas de intervención pedagógica que tengan como eje la competencia comunicativa desde sus múltiples variantes einterrelaciones.","palabras_clave":"comprensión lectora|aula taller|docentes |alumnos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":199,"idioma_id":5,"titulo":"LA DIDÁCTICA DE LO PROYECTUAL Y EL APRENDIZAJE PROFUNDO","resumen":"El presente trabajo se propone colaborar en la institución de una agenda contra-clásica, que ? como moción descolonial- procura potenciar el impulso de emancipación de las prácticas de la didáctica en el nivel superior, aun sujetadas a proposiciones eurocéntricas.En este sentido, el estudio de lo estético, la creatividad y otras cuestiones fronterizas con el misterio y lo inasible en la enseñanza se torna relevante, en tanto habilita formas de mirar inéditas, liberadas de las constricciones tecnocráticas del método y el contenido. En particular, el trabajo explora los componentes de la didáctica de lo proyectual que responden con fidelidad al aprendizaje humano genuino, en inquietante oposición a los modos escolares que suscitan la irrelevancia y el desamor. Sostiene así una definición de aprendizaje que trasciende la adquisición de un hábito por repetición hacia la posibilidad del pensamiento profundo, es decir, la promoción del conoser- esta actividad natural de los seres humanos que los tensiona desde el deseo por el conocimiento hacia la transformación de sí y sus circunstancias. Esperamos que tales recorridos reflexivos iluminen el entramado denso del currículo vivo de la formación de formadores, y estimulen la pulsión política a favor de la restitución del sentido y la relevancia de nuestras propuestas educativas","palabras_clave":"AGENDA CONTRA-CLÁSICA|DIDÁCTICA DE LO PROECTUAL|APRENDIZAJE PROFUNDO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":206,"idioma_id":4,"titulo":"Nickel hydroxide films in contact with an electroactive solution. A study employing electrochemical impedance measurements","resumen":"      The deactivation of nickel  hydroxide films after prolonged storage times without use was studied. This  study was carried out in the context of the Rotating Disc Electrode Voltammetry  (RDEV) and Electrochemical Impedance Spectroscopy (EIS) when the nickel  hydroxide film contacts an electroactive solution and a redox reaction occurs  at the Au-Ni(OH)2|electrolyte interface. Deferasirox (4-(3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl)  benzoic acid) was employed as redox species in solution.  Limiting currents vs. electrode rotation rate  dependences allowed one to obtain variation of the charge transport rate on the  storage time. EIS was employed to obtain a more complete series of  charge-transport parameters, that is, electron and ion diffusion coefficients  and different interfacial resistances related to the gold\/nickel hydroxide and  nickel hydroxide\/solution interfaces.  ","palabras_clave":"Nickel hydroxide films|Charge transport parameters|Ion and electron diffusion coefficients;"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":223,"idioma_id":5,"titulo":"Política científica e identidades institucionales en la universidad","resumen":"Las políticas de ciencia y tecnología  suelen analizarse en tanto políticas públicas de organismos  gubernamentales. Existen sin embargo también iniciativas de  promoción de la ciencia y la tecnología a otros niveles, como por  ejemplo el de las instituciones universitarias. En base a una  revisíón teórica y un estudio de caso, en el presente artículo me  propongo marcar tres ejes de análisis para las políticas  científicas universitarias. El primero se relaciona con el lugar de  la investigación en la definición de la identidad institucional  universitaria y opone universidad científica a profesionalista. El  segundo refiere a la libertad operacional de la institución, tanto a  nivel externo frente a su patrocinante, como a nivel interno, en lo  que hace a su forma de gobierno. En estos casos las oposiciones son  entre autonomía, intervencionismo, democracia y burocratización.  Finalmente, el tercer eje se vincula con la apropiación social de la  investigación universitaria, y opone una visión empresarial de la  universidad a otra ligada a la crítica social. Se concluye que la  dinámica de la política científica en la universidad tiene  componentes específicos relacionados con el peso de los actores que  participan y las identidades que la institución representa.        -----[Indizada en CLASE, DARE, Latindex Directorio, Latindex Catélogo, RedALyCNúcleo Básico Revistas Argentinas]  ","palabras_clave":"UNIVERSIDAD|POLITICA CIENTIFICA|AUTONOMIA|BUROCRATIZACION|IDENTIDAD INSTITUCIONAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":228,"idioma_id":4,"titulo":"Prevalence of autotomy and tail regeneration in Teius teyou (Reptilia, Teiidae).","resumen":"We analyzed the prevalence of tail autotomy and regeneration in Teius teyou with the use of 640 museum specimens.There is a marked difference in the prevalence of tail autotomy between juveniles (5.4%) and adults (23.9%); we found no significantdifferences in the prevalence between males and females. In contrast with the trends observed in other families, there exists an inverse relationship between the average size and the prevalence of autotomy among teiid species. We suggest that this could be explained by the important role played by the tail in locomotion, courtship, and defense of teiids. Alternatively, being a large species, these teiids may have an enhanced capacity for repelling attacks without losing their tails. Finally, we report a specimen that presented a bifidregenerated tail.","palabras_clave":"TAIL AUTOTOMY|TAIL REGENERATION|SEX|AGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":229,"idioma_id":5,"titulo":"Roberto Arlt, el sexo y los monstruos","resumen":"        En este artículo, se  considera a la ideología de la domesticidad como un aspecto relevante en el  imaginario social de la Argentina de la década del ´20. Como es sabido, esta  puede leerse en una multiplicidad de discursos y es desde ella que surgen dos  discursos resistentes denominados feminista y falogocéntrico. En este marco, se  analizará el modo en que Arlt, en Los siete locos- Los lanzallamas, exacerba y supera los límites  morales del falogocentrismo, poniendo en evidencia las posibilidades más  extremas que esta ideología permite. Puede decirse que el peso  de la norma sobre las identidades de género emerge como una singular  resistencia que produce al menos tres monstruos masculinos. De esta manera, la narrativa de Arlt trasluce una sensibilidad precisa de las  variantes del falogocentrismo que circulaban en los distintos discursos  epocales. &nbsp;&nbsp;  ","palabras_clave":"GÉNERO|LITERATURA ARGENTINA|ARLT|PODER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":319,"idioma_id":4,"titulo":"Economic Feasibility Study for Improving Drinking Water Quality: A Case Study of Arsenic Contamination in Rural Argentina","resumen":"Abstract: Economic studies are essential in evaluating the potential external investment support and\/orinternal tariffs available to improve drinking water quality. Cost?benefit analysis (CBA) is a useful tool to assessthe economic feasibility of such interventions, i.e. to take some form of action to improve the drinking waterquality. CBA should involve the market and non-market effects associated with the intervention. An economicframework was proposed in this study, which estimated the health avoided costs and the environmentalbenefits for the net present value of reducing the pollutant concentrations in drinking water. We conducted anempirical application to assess the economic feasibility of removing arsenic from water in a rural area ofArgentina. Four small-scale methods were evaluated in our study. The results indicated that the inclusion ofnon-market benefits was integral to supporting investment projects. In addition, the application of the proposedframework will provide water authorities with more complete information for the decision-makingprocess","palabras_clave":"ARSENIC|DRINKING WATER|COST-BENEFIT ANALYSIS|ENVIRONMENTAL BENEFITS|HEALTH EFFECTS|NON- MARKET BENEFITS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":371,"idioma_id":5,"titulo":"Exaptaciones, Cambio y Oportunismo en Arqueología","resumen":"Este trabajo introduce el concepto de exaptación y discute su utilidad y relevancia para el estudio arqueológico del cambio y la innovación tecnológica. Primero, se sintetizan la historia y formulaciones del término exaptación, y se explicitan las diferencias con el concepto de adaptación. Luego, se revisan conceptos arqueológicos temáticamente relacionados y se plantean similitudes y diferencias. A modo de ejemplo, diversos casos arqueológicos y etnográficos son utilizados para evaluar y problematizar la aplicación del concepto de exaptación a la investigación arqueológica. Por último, se propone que el uso de formas y técnicas preexistentes que no fueron concebidas o diseñadas para cumplir con dicho uso debe ser entendido como un mecanismo fundamental en la innovación tecnológica. Por lo tanto, la evaluación realizada sugiere que  la utilización del concepto de exaptación en arqueología no sólo puede contribuir al estudio del cambio cultural sino que resulta de utilidad para la exploración de sus causas.","palabras_clave":"EXAPTACIÓN|CAMBIO|INNOVACION TECNOLÓGICA|ARQUEOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":403,"idioma_id":5,"titulo":"El caso de Luis: moralidades, emociones y dispositivos penales de perdón","resumen":"El artículo propone reflexionar sobre el perdón como valor que organiza las relaciones que se despliegan en torno al tratamiento penal de la figura de inimputabilidad. Para ello se apoya en el análisis de una intervención en particular: el caso de Luis, quien fue procesado por varios asesinatos ocurridos en la década de 1980 en Argentina. Este recorrido se ofrece como explicación posible acerca del modo en que, dentro del funcionamiento del sistema penal, la mediación moral distingue emociones como forma de sustentar decisiones y prácticas determinadas. Al mismo tiempo se describen las transformaciones históricas que tuvieron lugar en una serie instituciones encargadas del tratamiento de Luis a lo largo de los veintiocho años de su internación.","palabras_clave":"EMOCIONES|VALOR MORAL|PERDÓN|MEDIDAS DE SEGURIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":405,"idioma_id":4,"titulo":"Nutrient allocation in the gonads of the sea urchin Arbacia dufresnii in different stages of gonadal development","resumen":"This study reports nutrient allocation in different stages of gonadal development for two populations of the sea urchin Arbacia dufresnii off the Patagonian coast of Argentina (Nuevo Gulf and San Jorge Gulf). The biochemical composition of gonads was used to assess nutrient allocation by measuring ash, soluble protein, lipid and trichloroacetic acid-soluble carbohydrate concentrations, and absolute contents over a 24-month period. Reproductive output in terms of energy was calculated for females. Results were correlated with istological stage of the gonads. Soluble proteins were the main component for the Nuevo Gulf population while unmeasured organic material (i.e. insoluble proteins and nucleic acids, especially in testes) was revalent in gonads from San Jorge Gulf. Soluble protein and lipid concentrations followed the gonadal cycle, while carbohydrate concentration was almost negligible, especially in the Nuevo Gulf population. The different patterns in the gonadal cycle in the two populations were reflected in the biochemical composition of gonads. Concentrations and contents of the biochemical components and reproductive output were higher in the population from San Jorge Gulf owing to the larger size of gonads and gametes. These findings contribute to the better understanding of the plasticity of the reproductive biology of A. dufresnii in different environments.","palabras_clave":"ECHINODERMATA|ECHINOIDEA|BIOCHEMICAL COMPOSITION|GONADAL STAGES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":407,"idioma_id":4,"titulo":"Analytical Applications of Microbial Fuel Cells. Part I: Biochemical Oxygen Demand","resumen":"Microbial fuel cells (MFCs) are bio-electrochemical devices, where usually the anode(but sometimes the cathode, or both) contains microorganisms able to generate andsustain an electrochemical gradient which is used typically to generate electrical power.In the more studied set-up, the anode contains heterotrophic bacteria in anaerobicconditions, capable to oxidize organic molecules releasing protons and electrons, aswell as other by-products. Released protons could reach the cathode (through amembrane or not) whereas electrons travel across an external circuit originating aneasily measurable direct current flow. MFCs have been proposed fundamentally aselectric power producing devices or more recently as hydrogen producing devices. Herewe will review the still incipient development of analytical uses of MFCs or relateddevices or set-ups, in the light of a non-restrictive MFC definition, as promising tools toasset water quality or other measurable parameters. An introduction to biological basedanalytical methods, including bioassays and biosensors, as well as MFCs design andoperating principles will be also included. Besides, the use of MFCs as biochemicaloxygen demand sensors (perhaps the main analytical application of MFCs), isdiscussed. In a companion review (Part 2), other new analytical applications arereviewed, as the use as toxicity sensors, metabolic sensors, life detectors, and otherproposed applications.","palabras_clave":"BIOSENSOR|BIOASSAY|BIOELECTROCHEMISTY|BOD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":408,"idioma_id":4,"titulo":"Analytical Applications of Microbial Fuel Cells. Part II: Toxicity, Microbial Activity and Quantification, Single Analyte Detection and other uses","resumen":"Microbial fuel cells were rediscovered twenty years ago, and now are a very activeresearch area; the reasons behind this new activity are the relatively recent discovery ofelectrogenic or electroactive bacteria, and the vision of two important practicalapplications, as wastewater treatment coupled with clean energy production and powersupply systems for isolated low power sensor devices. Although some analyticalapplications of MFCs were proposed earlier (as biochemical oxygen demand sensing),only lately a myriad or new uses of this technology are being presented by researchgroups around the world, which combine both, biological-microbiological andelectroanalytical expertise. This is the second part of a review of MFC applications inthe area of analytical sciences. In Part I a general introduction to biological basedanalytical methods, including bioassays, biosensors, MFCs design, operating principles,as well the perhaps main and earlier presented application, the use as a BOD sensor,was reviewed. In this Part II, all other proposed uses are presented and discussed.","palabras_clave":"MFC|TOXICITY|METABOLIC SENSOR|LIFE SENSOR|SINGLE ANALYTE SENSOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":410,"idioma_id":4,"titulo":"Efficient asymmetric TADDOLs-organocatalyzed cycloaddition for the synthesis of  allyltin derivatives","resumen":"We report here the results obtained in the study of organocatalytic asymmetric Diels?Alder reactions to optimize the synthesis of stereo defined allyltin derivatives using (Z)-2-(1-cyclohexenyl)-1-ethenyl(trineophyl)stannane (1) as diene and substituted dienophiles in the presence of (4R,5R)-&#945;,&#945;,&#945;&#8242;,&#945;&#8242;-tetraphenyl-1,3-dioxolane-4,5-dimethanol (TADDOL, I) and analogs (4R,5R)-&#945;,&#945;,&#945;&#8242;,&#945;&#8242;-tetra(1-naphtyl)-1,3-dioxolane-4,5-dimethanol (II) and (4R,5R)-&#945;,&#945;,&#945;&#8242;,&#945;&#8242;-tetra(9-phenantryl)1,3-dioxolane-4,5-dimethanol (III) as chiral catalysts to enhance stereoselectivity through hydrogen bond activation of the dienophile. Catalyst II provided excellent results and ultrasonic radiation at low temperature showed the shorter reaction times.","palabras_clave":"Asymmetric organocatalysis|TADDOLs|Diels?Alder|Reaction|Allyltin derivatives"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":412,"idioma_id":4,"titulo":"Quaternion based orientation estimation fusing a camera and inertial sensors for a hovering UAV","resumen":"Orientation estimation in quadrotors is essential for low-level stability control and for high-levelnavigation and motion planning. This is usually carried out by fusing measurements from different sensorsincluding inertial sensor, magnetic compass, sonar, GPS, camera, etc. In indoor environments, the GPSsignal is not available and the Earth?s magnetic field is highly disturbed. In this work we present a newapproach for visual estimation of the yaw angle based on spectral features, and a fusion algorithm usingunit quaternions, both applied to a hovering quadrotor. The approach is based on an Inertial MeasurementUnit and a downward-looking camera, rigidly attached to the quadrotor. The fusion is performed by means of an Extended Kalman Filter with a double measurement update stage. The inertial sensors provideinformation for orientation estimation, mainly for roll and pitch angles, whereas the camera is used for measuring the yaw angle. A new method to integrate the yaw angle in the measurement update of the filteris also proposed, using an augmented measurement vector in order to avoid discontinuities in the filterinnovation vector. The proposed approach is evaluated with real data and compared with ground truthgiven by a Vicon system. Experimental results are presented for both the visual yaw angle estimationand the fusion with the inertial sensors, showing an improvement in orientation estimation.","palabras_clave":"Orientation estimation|Quadrotor|IMU camera fusion|Unit quaternions"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":414,"idioma_id":4,"titulo":"Pyrolysis of sunflower seed hulls for obtaining bio-oils","resumen":"Sunflower Seed Hulls (SSH) were studied as a source of bio-oils from pyrolysis. As received hulls, hulls previously washed with diluted acid (SSHA) and hulls submitted to a mushroom enzymatic attack (BSSH)were analyzed.TGA and chemical composition analysis indicated that the concentration of lignin, hemicellulose and cellulose varies for with the pre-treatment.Pyrolysis was carried out in a glass reactor employing 3-5 g of biomass at 400ºC, under N2 flow. Bio-oilswereanalyzed with GC-chromatography and RMN. The liquid corresponding to SSH presented a relatively high concentration of acetic acid and a high instability to storage. The bio-oil from SSHA showed a more simple composition, with high concentration of furfural and an appreciable amount of levoglucosenone. Lignin was degraded upon enzymatic activity, for this reason BSSH led to the highest yield of bio-oil, with relative high concentration of acetic acid and  stability to storage.","palabras_clave":"Biomass|Pyrolsys|Biotransformation|sunflower seed husk"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":416,"idioma_id":4,"titulo":"CHALCONES AS ANALITYCAL REAGENTS OF ALUMINUM: STABILITY, THERMODYNAMIC AND KINETIC STUDY","resumen":"Chalcones, a group of polyphenolic compounds, has been studied for a long time due to their biological properties and their ability as analytical reagents. In this work the stability and thermodynamic parameters concerning the fotmation in ethanolic medium of two chalcone?aluminium complexes (2&#8242;,3-dihydroxychalcone-Al(III) and 2&#8242;,4&#8242;,3-trihydroxychalcone-Al(III)) were studied and a kinetic study of the formation reaction was aslo performed. Both systems showed 1:1 L&#8239;:&#8239;M stoichiometry and stability constants at four temperatures were determined. Thermodynamic parameters indicate that both formation reactions are endothermic and driving force is entropic. Kinetic study revealed that 2&#8242;,4&#8242;,3-trihydroxychalcone-Al(III) formation is faster than 2&#8242;,3-dihydroxyclacone-Al(III), a factor which can be interesting when proposing new analytical reagents.","palabras_clave":"ALUMINIUM|CHALCONES|COMPLEXES|KINETIC|STABILITY CONSTANTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":417,"idioma_id":4,"titulo":"Estimation of Viscoelastic Arterial Wall Transfer Function based on Volume Compensation Method","resumen":"The viscoelastic arterial wall transfer function was determined noninvasively based on pressure and diameter signals of the finger artery measured sequentially using the volume compensation method. The uncompensated arterial diameter variations were converted to pressure using the estimated transfer function parameters. This pressure signal was negligible compared to measured pressure except at systole when reduction of 9 mmHg was achieved, thus correcting the volume compensation methods error. To validate the method, central aortic pressure should be reconstructed from finger artery measurements and compared to invasive methods.","palabras_clave":"BLOOD|PRESSURE|VOLUME|COMPENSATION|VISCOELASTIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":422,"idioma_id":4,"titulo":"A study of the temperature effect on Hantzsch reaction selectivity using Mn and Ce oxides under solvent-free conditions","resumen":"In this communication, four materials (CeO2, CeO2(Cu), MnOx, and MnOx(Cu)) were prepared, characterized and tested as catalysts, in solvent-free conditions, for the multicomponent Hantzsch reactions to obtain alternatively the 1,4-dihydropyridine or 2-phenylpyridine depending on the reaction conditions. 1,4-Dihydropyridine 4 was the main product formed at 80 °C (76%), and 2-phenylpyridine 7 was the main product at 40 °C (91%), in  oxidant-free conditions, using CeO2 catalyst. It is the first report that shows that, not only the temperature but  also the nature of the catalyst may change the product selectivity in Hantzsch reactions.","palabras_clave":"CERIUM AND MANGANESE OXIDES|HANTZSCH REACTION|1,4-DIHYDROPYRIDINE|2-PHENYLPYRIDINA|GREEN CHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":425,"idioma_id":4,"titulo":"Evaluation of Lactobacillus paracasei subsp. tolerans isolated from Jenyn's sprat (Ramnogaster arcuata) as probiotic for juvenile rainbow trout Oncorhynchus mykiss (Walbaum, 1792)","resumen":"A lactic acid bacterial strain, Lactobacillus paracasei subsp.tolerans F2, isolated from the intestine of Ramnogasterarcuata, was evaluated as a growth promoter in juvenilerainbow trout Oncorhynchus mykiss (Walbaum, 1972) farm-ing. In addition, the safety of the strain was assessedaccording to the FAO recommendations. Strain F2 wassusceptible to most antibiotics tested and no evidence ofhemolytic activity was found. When the strain of Lactoba-cillus paracasei subsp. tolerans F2 was administered withfood, no adverse e&#64256;ects on health were observed and &#64257;sh biomass increased 12% more in the treatment group thanin the control group. Signi&#64257;cant di&#64256;erences were detectedin the speci&#64257;c growth rate and feed conversion ratio. Inthe group receiving Lactobacillus paracasei subsp. toleransF2-supplemented feed, quantitative di&#64256;erences in the micro-bial composition of &#64257;sh feces with respect to the controlgroup were observed. An important decrease in fungi andenterobacteria was observed in feces from the treatmentgroup, coincident with an increase in lactic acid bacteria.This result would indicate a change in the composition ofthe intestinal microbiota of &#64257;sh treated with the putativeprobiotic. These results suggest that the strain of Lactoba-cillus paracasei subsp. tolerans F2 has the applicationpotential to improve the performance in rainbow trout","palabras_clave":"Probioticos|bacterias lacticas|acuicultura|Trucha Arcoiris"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":426,"idioma_id":5,"titulo":"Expansionismo turístico, poblaciones indígenas Mapuche y territorios en conflicto en Neuquén, Argentina","resumen":"En el presente artículo nos proponemos analizar los diversos conflictos asociados a la actividad turística, protagonizados por diferentes organizaciones y comunidades del pueblo indígena Mapuche en el denominado Corredor de los Lagos de la Provincia de Neuquén, Argentina. Atenderemos las causas, dinámicas y efectos de estos litigios y al mismo tiempo, vincularemos estos procesos con la particular visibilización que se efectúa de lo Mapuche bajo contextos turísticos, por parte de diferentes agentes estatales y privados, confrontando el modo en que dicha presencia es apropiada y redefinida por los integrantes de las organizaciones y de las comunidades de este pueblo originario","palabras_clave":"Expansión turística|Comunidades Mapuche|Conflictos|Provincia de Neuquén"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":428,"idioma_id":4,"titulo":"Evolutionary-Statistical System: a Parallel Method for Improving Forest Fire Spread Prediction","resumen":"Fighting fires is a very risky job, where loss of life is a real possibility. Proper training is essential. Several firemen academies offer courses and programs whose goal is to enhance the ability of fire and emergency services to deal more effectively with fire. Among the tools that can be found in the training process are fire simulators, which are used both for training and for the prediction of forest fires. In many cases, the used simulators are based on models that present a series of limitations related to the need for a large number of input parameters. Moreover, such parameters often have some degree of uncertainty due to the impossibility of measuring all of them in real time. Therefore, they have to be estimated from indirect measurements, which negatively impacts on the output of the model. In this paper we present a method which combines Statistical Analysis with Parallel Evolutionary Algorithms to improve the quality of the model output.&nbsp;","palabras_clave":"PARALLEL EVOLUTIONARY ALGORITHMS|STATISTICAL SYSTEM|FOREST FIRE PREDICTION|HIGH PERFORMANCE COMPUTING|PARALLEL PROCESSING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":429,"idioma_id":4,"titulo":"Capabilities of several phosphonium ionic liquids for arsenic species determination in water by liquid-liquid microextraction and electrothermal atomic absorption spectrometry","resumen":"The capabilities of several phosphonium-ionic liquids (PILs) to form ion-pairs with a complex obtained by reaction of arsenate species with molybdate were evaluated. Phosphonium-ILs containing the tetradecyl(trihexyl)phosphonium cation but different anions (dicyanamide and decanoate) and tributyl(methyl)phosphonium methylsulphate IL were studied. Size, polarity and localization of charges in PILs cations showed to influence their capability to form ion-pairs with arsenomolybdate (AsMo12O403-) complex and to extract As(V). The performance of PILs was compared with that showed by a widely used ion-pairing reagent such as cethyltrimethylamonium bromide (CTAB). Finally, the IL tetradecyl(trihexyl)phosphonium dicyanamide was chosen to develop a liquid-liquid microextraction (LLME) procedure using only 80 &#956;L of tetrachloroethylene as extractant. The organic phase was directly injected into the graphite furnace of an electrothermal atomic absorption spectrometer (ETAAS) for As determination. An extraction efficiency of 100% and a preconcentration factor of 130 were obtained with 5 mL of sample. The detection limit was 1.9 ng L-1 and the relative standard deviation for six replicate measurements of 1.0 &#956;g L-1 for As were 4.9%, 5.0% and 5.1% for As(V), As(III) and organic As species, respectively.","palabras_clave":"Ionic liquids|Phosphonium|Speciation|Arsenic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":430,"idioma_id":4,"titulo":"RADIOLOGICAL EVALUATION OF RADIAL BONE DEFECTS TREATED WITH DEMINERALIZED BONE MATRIX IN AN EXPERIMENTAL RABBIT MODEL","resumen":"Demineralized bone matrix (DBM) is often used to treat bone defects due to its osteoinductive and osteoconductive properties. The aim of this work is to evaluate the characteristics and evolution of the repair of experimental radial orthopaedic bone defects treated with DBM. DBM was prepared from rabbit bone obtained from cadavers, which were fragmented, defatted, demineralized and preserved in alcohol. Ten New Zealand rabbits were used. Critical size defects were created in one of the radiuses.The defects of 8 rabbits were filled with DBM while the other 2 rabbits did not receive any treatment.Each rabbit was radiologically followed at 15, 25, 40, 60 and 90 days. The untreated animals did not show presence of new bone in relation to the defect, whereas the DBM-treated defects were completely filled at day 90. The presence of new bone was evident from day 15 onward until the entire defect was repaired. The production of bone at each post operative period was statistically significant (P0.05). The pattern of defects? repair started with presence of new bone at the extremes of defects and continued towards their centre.","palabras_clave":"bone|demineralized bone matrix|osteotomy |rabbit|radiology|radius defect"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":431,"idioma_id":4,"titulo":"Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in pre-pubertal rats. Effects on early folliculogenesis","resumen":"The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3&#956;g\/kg\/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.","palabras_clave":"Bisphenol A|LUTEINIZING HORMONE|FOLLICLE STIMULATING HORMONE|Estradiol"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":432,"idioma_id":4,"titulo":"Atomistic modeling of Ag, Au, and Pt nanoframes","resumen":"Cubic monoatomic nanoframes of Ag, Au, and Pt were  modeled in terms of their evolution with temperature. Using an approximate  quantum method for the energetics, Monte Carlo atomistic simulations were performed  to determine the critical temperatures at which the nanoframe evolves from its  original shape to either a cluster of nanoparticles after all sides of the  frame are broken, or to a large cluster after collapsing onto its own internal  void. The mechanisms by which these two behaviors take place are discussed within  the framework of a simple rule which determines the relationship between the  structural factors (side and width) that characterize the transition from one  to the other.","palabras_clave":"BFS Method|Nanoframe|Metallics Nanocage"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":433,"idioma_id":4,"titulo":"Identifi cation of potentia l areas to achieve stable energy production using the SWERA datab ase: A case study of northern Chile","resumen":"The South American High Plateau (Altiplano) is one of the few regions on the planet believed to receive, at certain sites, an annual mean daily direct solar irradiation greater than 9 kWh\/m2 (32.4 MJ\/m2). The veracity of this estimation is important because it implies that establishing large solar power stations in  the region would be highly profitable. However, the measured data are highly localised, and the knowledge of the spatial distribution of the resource could be insufficient. To address this problem, the global and direct normal solar radiation data measured at eight stations distributed in northern Chile were compared with the SWERA database for South America. The differences found between the estimated and measured values were as high as 11%, on an annual basis. Thus, the SWERA database could be used to construct maps of the isolines of direct solar radiation to help visualise the spatial distribution of the resource. An analysis was performed to determine the per cent variation of a solar field collection area designed to achieve stable energy production throughout the year. Based on the analysis results, the northern region of Chile presents an economic potential much greater than that of the Mojave Desert from the point of view of the economic risk for a solar venture. This information can serve as a useful and reliable tool because it represents the initial  assessments of optimal sites for installing solar power stations.","palabras_clave":"Chile|satellite database|direct normal irradiance|maps|economic potential"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":434,"idioma_id":4,"titulo":"Chlorpyrifos inhibits cell proliferation through ERK1\/2 phosphorylation in breast cancer cell lines","resumen":"It is well known the participation of oxidative stress in the induction and development of different pathologies including cancer, diabetes, neurodegeneration and respiratory disorders among others. It has been reported that oxidative stress may be induced by pesticides and it could be the cause of health alteration mediated by pollutants exposure. Large number of registered products containing chlorpyrifos (CPF) is used to control pest worldwide. We have previously reported that 50&#956;M CPF induces ROS generation and produces cell cycle arrest followed by cell death. The present investigation was designed to identify the pathway involved in CPF-inhibited cell proliferation in MCF-7 and MDA-MB-231 breast cancer cell lines. In addition, we determined if CPF-induced oxidative stress is related to alterations in antioxidant defense system. Finally we studied the molecular mechanisms underlying in the cell proliferation inhibition produced by the pesticide. In this study we demonstrate that CPF (50&#956;M) induces redox imbalance altering the antioxidant defense system in breast cancer cells. Furthermore, we found that the main mechanism involved in the inhibition of cell proliferation induced by CPF is an increment of p-ERK1\/2 levels mediated by H2O2 in breast cancer cells. As PD98059 could not abolish the increment of ROS induced by CPF, we concluded that ERK1\/2 phosphorylation is subsequent to ROS production induced by CPF but not the inverse.","palabras_clave":"CHLORPYRIFOS|BREAST CANCER|REACTIVE OXYGEN SPECIES|CELL PROLIFERATION|LIPID PEROXIDATION|ERK 1\/2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":435,"idioma_id":4,"titulo":"Topological Additive Numbering of Directed Acyclic Graphs","resumen":"We propose to study a problem that arises naturally from   both Topological Numbering of Directed Acyclic Graphs, and Additive   Coloring (also known as Lucky Labeling). Let D &nbsp; be a digraph and f &nbsp; a labeling of its vertices with positive integers; denote by S(v)S(v) the sum of labels over all neighbors of each vertex v &nbsp;. The labeling f &nbsp; is called topological additive numbering &nbsp; if S(u)&lt;S(v)S(u)&lt;S(v) for each arc (u,v)(u,v) of the digraph. The problem asks to find the minimum number k &nbsp; for which D &nbsp; has a topological additive numbering with labels belonging to {1,?,k}{1,?,k}, denoted by &#951;t(D)&#951;t(D).            We characterize when a digraph has topological additive numberings, give a lower bound for &#951;t(D)&#951;t(D) and provide an integer programming formulation for our problem. We also present some families for which &#951;t(D)&#951;t(D) can be computed in polynomial time. Finally, we prove that this problem is NPNP-Hard even when its input is restricted to planar bipartite digraphs.","palabras_clave":"Lucky labeling|Directed acyclic graphs|Topological additive numbering|Computational complexity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":437,"idioma_id":4,"titulo":"Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism","resumen":"The absence of phytoestrogens in the diet during pregnancy has been reported to result in obesity later  in adulthood. We investigated whether phytoestrogen withdrawal in adult life could alter the hypothalamic  signals that regulate food intake and affect body weight and glucose homeostasis.  Male Wistar rats fed from conception to adulthood with a high phytoestrogen diet were submitted  to phytoestrogen withdrawal by feeding a low phytoestrogen diet, or a high phytoestrogen?high fat diet.  Withdrawal of dietary phytoestrogens increased body weight, adiposity and energy intake through an  orexigenic hypothalamic response characterized by upregulation of AGRP and downregulation of POMC.  This was associated with elevated leptin and T4, reduced TSH, testosterone and estradiol, and diminished  hypothalamic ER&#945; expression, concomitant with alterations in glucose tolerance.  Removing dietary phytoestrogens caused manifestations of obesity and diabetes that were more pronounced  than those induced by the high phytoestrogen?high fat diet intake.","palabras_clave":"PHYTOESTROGENS|OBESITY|HYPOTHALAMUS|GLUCOSE METABOLISM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":439,"idioma_id":4,"titulo":"Ghrelin effects expression of several genes associated with depression-like behavior","resumen":"Ghrelin (Ghr) is an orexigenic peptide that is being investigated for its potential role in development of anxiety-like behavior and modulation of depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. Olfactory bulbectomy is an animal model useful to study of depression and Ghr could be an alternative therapeutic tool in depression therapy. We studied the effects of intracerebroventricular (i.c.v.) Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH). We found that acute Ghr 0.3 nmol\/&#956;l administration increases gene expression of DOR, SERT and LHCGR in OB mice and decreased expression of IL-1b, suggesting that these genes could be involved in the antidepressant-like effects of Ghr. In addition, OB animals exhibit high AVP gene expression and elevated plasma concentrations of AVP and ACTH and acute Ghr 0.3 nmol\/&#956;l administration reduces AVP gene expression and the concentration of these hormones, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP. In conclusion, this study provides new evidence about genes, receptors and hormones involved in the antidepressant mechanism\/s induced by Ghr in OB animals.","palabras_clave":"Ghrelin |depression like behavior|depression genes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":440,"idioma_id":4,"titulo":"Lipid oxidation in biscuits: Comparison of different lipid extraction methods","resumen":"This study was conducted in order to describe aproper method of extraction and quantification of peroxides ina complex matrix as biscuits. Different lipid extractionmethods were applied in low lipid biscuits: direct solventextraction; conventional Soxhlet extraction, the AmericanAssociation of Cereal Chemists (AACC) method and amodification of the AACC method, in which the heating of thesample was avoided. Furthermore, the quantification methodof peroxides was simplified and adapted to samples with lowlipid content using easily accessible equipment. Significantdifferences (p B 0.05) were found in the peroxide value of thelipids extracted with different extraction procedures. All theextraction methods performed, except the AACC, were foundto be suitable for the determination of peroxides in low lipidbiscuits. However, as direct solvent extraction provided afaster and simpler analysis, this method seemed to be the mostsuitable for peroxide determination in low lipid biscuits.","palabras_clave":"LIPID OXIDATION|BISCUIT|LIPID EXTRACTION METHOD|FERRIC THIOCYANATE ASSAY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":443,"idioma_id":5,"titulo":"PASAS DE UVA DE BAJAS CALORIAS OBTENIDAS POR DESHIDRATACIÓN COMBINADA: OPTIMIZACION DEL PROCESO Y EVALUACIÓN DE LA EFICIENCIA ANTIOXIDANTE","resumen":"Se describe el desarrollo de un alimento deshidratado saludable de elevada calidad nutricional y valor agregado: uva pasa de bajo contenido calórico, obtenida mediante deshidratación combinada asistida por ultrasonido llevada a cabo mediante un tratamiento osmótico dual (D3S) de dos etapas complementado por secado por aire caliente. Se trabajó con uva rosada variedad Red Globe producida en la Provincia de Mendoza (Argentina), las cuales fueron sometidas a un proceso de sustitución de los azúcares propios de la fruta por edulcorante natural Stevia en dos etapas basado en ósmosis bajo diferentes condiciones: tipo de tratamiento (con\/sin aplicación de ultrasonido); concentración del edulcorante (18, 20, 22% p\/p), tiempo de ósmosis (35, 75 y 115 minutos). Se evaluaron las variables de control contenido de sólidos solubles (SS), de humedad (M) y de polifenoles totales (PF), eficiencia antioxidante (AE) y perfil de composición de azúcares. La optimización múltiple del proceso de deshidratación combinada realizada por la metodología de superficie de respuesta y análisis de deseabilidad, permitió determinar las condiciones que minimizan M, maximizando SS (incorporación de Stevia) y conservando la máxima cantidad PF. El tratamiento óptimo redujo un 32% los azúcares mayoritarios de la uva (sacarosa, glucosa) tras la primera etapa, y el 57% de ellos al final del proceso de deshidratación.","palabras_clave":"PASAS DE UVA|SUSTITUCION DE AZUCARES|ANTIOXIDANES POLIFENOLES|STEVIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":444,"idioma_id":4,"titulo":"Automatic detection of epileptic Seizures in long-term EEG records","resumen":"Epilepsy is a neurological disorder which affects nearly 1.5% of the world´s total population.  Trained physicians and neurologists visually scan the long-term electroencephalographic (EEG)  records to identify epileptic seizures. It generally requires many hours to interpret the data.  Therefore, tools for quick detection of seizures in long-term EEG records are very useful. This  study proposes an algorithm to help detect seizures in long-term iEEG based on low  computational costs methods using Spectral Power and Wavelet analysis. The detector was tested  on 21 invasive intracranial EEG (iEEG) records. A sensitivity of 85.39% was achieved. The  results indicate that the proposed method detects epileptic seizures in long-term iEEG records  successfully. Moreover, the algorithm does not require long processing time due to its simplicity.  This feature will allow significant time reduction of the visual inspection of iEEG records  performed by the specialists.","palabras_clave":"Epilepsy|Intracranial EEG records (iEEG)|Power Spectrum|EEG frequency bands|Wavelet decomposition"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":445,"idioma_id":4,"titulo":"Controlled growth of extended arrays of CoSi2 hexagonal nanoplatelets buried in Si(001), Si(011) and Si(111) wafers","resumen":"Because of their high electrical conductivity CoSi2 nanostructures are potential candidates for preparing ordered nano-arrays to be used as electrode interconnectors and contacts in microelectronic devices. We here describe a controlled procedure for the endotaxial growth of hexagonal CoSi2 nanoplatelets buried in differently oriented single crystalline Si wafers on which a Co-doped SiO2 thin film was previously deposited. These nanomaterials were obtained by a clean procedure consisting of isothermal annealing at 750 °C under a He atmosphere of Co-doped SiO2 thin films deposited onto the surface of three differently oriented flat Si substrates, namely Si(001), Si(011) and Si(111). Buried CoSi2 nanoplatelets are in all cases spontaneously formed as a consequence of the diffusion of Co atoms into the silicon wafer and their reaction with host Si atoms. Our TEM and GISAXS analyses demonstrated that these arrays, irrespective of host Si orientation, consist of CoSi2 hexagonal nanoplatelets in all cases parallel to Si{111} crystallographic planes. Additionally, the dimensions of the nanoplatelets were consistently determined by TEM and GISAXS for the three different host Si single crystal orientations.","palabras_clave":"CoSi2 nanostructures|Endotaxial growth|Co diffusion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":446,"idioma_id":4,"titulo":"In situ generated TiO2 over zeolitic supports as reusable photocatalysts for the degradation of dichlorvos","resumen":"Materials based on titania supported on zeolitic matrices (HBETA, HY and HZSM5) were synthesized by in situ generation of TiO2. The supported catalysts characterized by XRD indicate the presence of the anatase phase alone. The materials were also characterized by FTIR, SBET, and UV-VIS DRS. A high TiO2 content produced lower degradation, due to the presence of TiO2 particle aggregates of greater size on the zeolite matrix surface, as evidenced by the calculated crystal size. TiO2\/HBETA(20%) presented more activity than TiO2 supported on the other matrices due to higher adsorption of dichlorvos on HBETA. It has more surface area and a lower band gap value too, which makes it more effective. The mineralization degree is lower than the degradation percentage due to the formation of organophosphorous intermediates that are less toxic than the starting material. The complete degradation and mineralization of the pollutant was obtained in 360 and 540 min of reaction with TiO2\/HBETA(20%), respectively. This catalyst resulted in degradation percentages close to that of commercial TiO2 P25. The main advantage of supported catalysts is their easy separation and reuse, in this case resulting in a very low activity loss during eight cycles. These materials present suitable properties to be used as catalysts in the photocatalytic treatment of wastewater that contains pesticide dichlorvos in water.","palabras_clave":"Photodegradation|Dichlorvos|Titanium dioxide |  Zeolites"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":447,"idioma_id":5,"titulo":"Evaluación de la geoquímica e isótopos del nitrato en el acuífero  libre de una llanura con actividad agropecuaria,   Córdoba,   Argentina","resumen":"Fertilizers and livestock wastes can contaminate groundwater with nitrates. It is possible to use nitrate isotopes (15N and 18O) as a tool to discriminate different nitrate sources. The objective of this work was to identify contamination sources using water geochemical characteristics and nitrate stable isotopes in a drainage basin in the South of Cordoba province, Argentina. The observed nitrate concentration in 23 samples ranged from 3.0 to 193.0 mg\/L, most exceeding the local natural background (7.5 mg\/L) indicating pollution of the aquifer in addition to the contribution of other ions. The isotopic values of selected samples ranged from +6.4 permil to +12.3 permil for d15N and from +2.0 permil to +8.0 permil for d18O. Nitrate isotope enrichment mainly caused by denitrification (verified with epsN\/epsO = 1.5) and volatilization processes in the soil, before nitrates arrive to the aquifer, shifted the isotope values out from the designated fields for each source, making difficult their discrimination. The nitrates supply which shows best evidences was the punctual pollution from livestock sources, although there were other indicators like chemical variables and Escherichia coli bacteria.","palabras_clave":"isotopos estables oxigeno y nitrógeno|desnitrificación|agroquímicos|cría de ganado"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":448,"idioma_id":4,"titulo":"Cheese whey fermented with kefir micro-organisms: Antagonism against Salmonella and immunomodulatory capacity","resumen":"The antagonistic effect against Salmonella spp. and the immunomodulatory capacity of whey fermented with kefir grains and with three strains isolated from them ? Lactobacillus plantarum CIDCA 8327, Lactobacillus kefiri CIDCA 8348 and Kluyveromyces marxianus var. marxianus CIDCA 8154 ? were evaluated. Both fermented products interfered with the capacity of Salmonella spp. To associate and invade Caco-2\/TC7 cells and reduced up to the basal level the expression of the  CCL20 in response to a pro-inflammatory stimulus on Caco-2 CCL20:luc cells. The products with potential application as probiotics obtained by fermentation of whey with kefir micro-organisms represent an alternative to increase whey economic value","palabras_clave":"Immunomodulation|Kefir|Antagonism|Yeast"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":449,"idioma_id":5,"titulo":"Representaciones de migrantes senegaleses en la sociedad porteña de Buenos Aires. Apuntes sobre exotismo y exotización","resumen":"En este artículo presentamos algunos registros de campo y reflexiones a modo de avance de dos investigaciones que tienen por objeto de estudio a la migración senegalesa reciente en Argentina y sus relaciones sociales en el contexto local, concretamente en las ciudades de Buenos Aires y La Plata.  Específicamente, a partir de datos etnográficos, reflexionamos acerca del exotismo y la exotización como formas de percepción, relación y representación respecto de estas alteridades migrantes 'negras'.   Además, nuestro análisis avanza en interpretar fenómenos que vinculamos con esos modos de construcción de la alteridad, nos referimos a una hipervisibilidad de las personas 'negras' y al desconocimiento social respecto de África, los africanos y los afrodescendientes en el contexto local.  Planteamos a manera de hipótesis que el exotismo y la exotización de los recientes migrantes senegaleses se presentan en una relación de correspondencia\/complementariedad con el proceso de invisibilización que pesó históricamente sobre los 'negros' africanos y afrodescendientes en Argentina. En este marco, elaboramos una reflexión sobre las representaciones actuales al tiempo que contextualizamos las mismas en el marco de los procesos de alterización históricos de la sociedad nacional en relación con la población 'negra' de origen africano.","palabras_clave":"MIGRANTES SENEGALESES|EXOTISMO|RACISMO|REPRESENTACIONES SOCIALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":450,"idioma_id":4,"titulo":"Analysis of water footprint of potato production in the pampean region of Argentina","resumen":"The water footprint of a given product is an indicator of freshwater resources appropriation which brings valuable insight about the environmental impact of consuming the product. The aim of this study is to quantify the water footprint of potato production in the southeast of Buenos Aires province (Argentina). In this area, potatoes are irrigated using groundwater while, at the same time, both fertilizers and agrochemicals are applied. In order to assess the virtual water content of potato production, the green, blue and grey components of the water footprint were estimated. We considered the different volumes of water involved in the crop production from evaporation, rainfall, irrigation and fertilizers pollution. Crop evaporation and irrigation requirements were calculated. Data from application of irrigation were obtained from farmers. Nitrogen fertilization was considered as an indicator to estimate the grey component. The water footprint of potato in this region was 323.99 m3\/t. The evaporative water use (blue and green components) was 56.4%. The relative importance of blue water (24.15%), compared with global estimations, showed the significant role of irrigation on this crop. Groundwater reserves can be affected as a consequence of its intensive exploitation for irrigation. The fraction of grey water (43.6%) was the greatest, indicating the importance of nitrogen fertilizers and the risk of groundwater pollution.  This study allowed to evaluate the groundwater appropriation by potato production and emphasized the relevance of agriculture practices, such as irrigation and fertilizers, in addition to exploitation conditions and legal aspects on the water footprint of the crop. This work demonstrated the lack of sustainability of that production in the studied region and its possible effects on the hydrological system. Hence, several strategies and recommendations emerged from this study in order to reduce the water footprint and achieve the sustainability of potato production, regarding improvements on the irrigation and fertilization efficiencies, technical advice for farmers, and legal and tax regulation on groundwater use","palabras_clave":"Water footprint|virtual water|potato|groundwater"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":451,"idioma_id":4,"titulo":"A MILP-based column generation strategy for managing large-scale maritime distribution problems","resumen":"This paper presents a novel column generation algorithm for managing the logistics activities performed by a fleet of multi-parcel chemical tankers. In our procedure, for providing elementary routes, the conventional dynamic programming routes-generator is replaced by an efficient continuous-time MILP-slave problem. The performance of the decomposition method is evaluated by solving several examples dealing with the operations of a shipping company operating in the Asia Pacific Region. Computational results show that the proposed approach outperforms a pure exact optimization model and an alternative heuristic solution method reported in the literature.","palabras_clave":"TRAMP SHIPPING|SHIP ROUTING AND SCHEDULING|COLUMN GENERATION|MILP-SLAVE-FORMULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":452,"idioma_id":4,"titulo":"Multilayer emulsions as a strategy for linseed oil microencapsulation-effect of pH and alginate concentration","resumen":"The influence of pH (4-7) and sodium alginate (SA) concentration (0.125-0.25 wt%) on the properties of linseed oil-in-water emulsions stabilized by a whey protein isolate (WPI) was investigated. Droplet size, droplet charge, creaming stability and optical microscopy measurements as well as determination of non-adsorbed biopolymers at the oilewater interface were made. At pH 6 and 7, anionic alginate did not adsorb onto the surfaces of WPI-coated droplets due to strong electrostatic repulsion between biopolymers. Remaining SA molecules in the continuous phase induced emulsion destabilization by depletion flocculation, with the formation of floc chains that, after a period of latency, promoted phase separation with high creaming indexes. Both the delay time and the cream layer thickness increased when increasing SA concentration. At pH 5, z-potential measurements demonstrate deposition of SA onto WPI  interfacial membrane to form a bilayer around oil droplets. Besides, no droplet aggregation was observed and emulsions were stable to creaming after one-week storage. At pH 4, 0.125 wt% SA emulsions were prone to extensive droplet aggregation probably enhanced by bridging flocculation, exhibiting a gel-like microstructure of interconnected flocs, which then promoted phase separation. However, when increasing initial SA concentration in these systems, the degree of droplet aggregation decreased. These results suggest that the best conditions to produce stable emulsions as encapsulation matrices for the delivery of high polyunsaturated fatty acid oils would be 0.25 wt% SA pH 5.","palabras_clave":"EMULSION STABILITY|SODIUM ALGINATE|WHEY PROTEIN ISOLATE|FLOCCULATION|CREAMING|LAYER-BY-LAYER DEPOSITION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":454,"idioma_id":4,"titulo":"Weight and height percentiles calculated by the LMS method in Argentinean schoolchildren. A comparative references study","resumen":"Background: The Argentinean population is characterized by ethnic, cultural and  socio-economic diversity.  Aim: To calculate the percentiles of weight-for-age (W\/A) and height-for-age (H\/A) of  schoolchildren from Argentina employing the LMS method; and to compare the obtained  percentiles with those of the international and national references.  Subjects and methods: Anthropometric data of 18 698 students (8672 girls and 10 026 boys) of  3?13 years old were collected (2003?2008) from Buenos Aires, Catamarca, Chubut, Jujuy,  La Pampa and Mendoza. Percentiles of W\/A and H\/A were obtained with the LMS method.  Statistical and graphical comparisons were established with the WHO (international reference)  and with that published by the Argentinean Paediatric Society (national reference).  Results: Differences in W\/A and H\/A, regarding the references, were negative and greater at  the highest percentiles and in most of the age groups. On average, the differences were greater  for boys than girls and for national than international references.  Conclusion: The distribution of weight and height of schoolchildren, coming from most regions  of the country, differs from those of national and international references. It should be  advisable to establish a new national reference based on internationally recognized  methodological criteria that adequately reflect the biological and cultural diversity of the  Argentinean populations.","palabras_clave":"Weight and height| LMS method|Argentinean schoolchildren|comparative references study"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":456,"idioma_id":4,"titulo":"Genome sequence analysis of Pseudomonas extremaustralis provides new insights into environmental adaptability and extreme conditions resistance","resumen":"The genome of the Antarctic bacterium Pseudomonasextremaustralis was analyzed searching for genesinvolved in environmental adaptability focusing on anaerobicmetabolism, osmoregulation, cold adaptation, exopolysaccharideproduction and degradation of complexcompounds. Experimental evidences demonstrated thefunctionality of several of these pathways, including arginineand pyruvate fermentation, alginate production andgrowth under cold conditions. Phylogenetic analysis alongwith genomic island prediction allowed the detection ofgenes with probable foreign origin such as those coding foracetate kinase, osmotic resistance and colanic acid biosynthesis.These findings suggest that in P. extremaustralisthe horizontal transfer events and\/or gene redundancycould play a key role in the survival under unfavorableconditions. Comparative genome analysis of these traits inother representative Pseudomonas species highlightedseveral similarities and differences with this extremophilebacterium.","palabras_clave":"MICROAEROBIC METABOLISM|EXOPOLYSACHARIDES|GENOME ANALYSIS|ENVIRONMENTAL ADAPTABILITY|HORIZONTAL TRANSFER|PSEUDOMONAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":457,"idioma_id":4,"titulo":"Faster-is-slower effect in escaping ants revisited: Ants do not behave like humans.","resumen":"In this work we studied the trajectories, velocities and densities of ants when egressing under controlled levels of stress produced by a chemical repellent at different concentrations. We found that, unlike other animals escaping under life-and-death conditions and pedestrian simulations, ants do not produce a higher density zone near the exit door. Instead, ants are uniformly distributed over the available space  allowing for efficient evacuations. Consequently, the faster-is-slower effect observed in ants (Soria et al., 2012) is clearly of a different nature to that predicted by de social force model. In the case of ants,  the minimum evacuation time is correlated with the lower probability of taking backward steps. Thus, as biological model ants have important differences that make their use inadvisable for the design of human  facilities.","palabras_clave":"EMERGENCY|&#65279;EVACUATION|EGRESS|ANT EGRESS |CROWD EGRESS|FASTER IS SLOWER|PEDESTRIAN EVACUATION|PEDESTRIAN DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":458,"idioma_id":4,"titulo":"A solid- and solution-phase-based library of 2beta-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines","resumen":"We described the design, synthesis and antiproliferative properties of a series of twenty 2&#946;-methyl substituted penicillin derivatives.","palabras_clave":"BETA-METHYL SUBSTITUTED PENICILLIN DERIVATIVES|TUMOR CELL LINES|ANTITUMORAL COMPOUNDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":461,"idioma_id":5,"titulo":"El rol del Estado en la gestión de los recursos hídricos, en el área de influencia del Proyecto Mandisovi, Entre Ríos, Argentina.","resumen":"El agua constituye un bien de dominio público, en consecuencia le compete al Estado  la regulación de su uso o aprovechamiento, en función del interés público. Sin embargo, los códigos de aguas provinciales han incorporado pocos principios en la gestión de los recursos hídricos que aseguren su equitativa distribución.  Este estudio se orienta a la identificación y caracterización de los potenciales usuarios del recurso hidrico en el ?Proyecto de sistematización y distribución  del agua Mandisoví Chico?, en la provincia de Entre Ríos, Argentina.  Para ello, en base a una encuesta por muestreo se realizó un análisis descriptivo de las variables estructurales y de comportamiento que caracterizan a los productores que ?adhirieron? al proyecto y aquellos que ?no adhirieron? El análisis permite señalar que la escala y la orientación productiva expresan con mayor intensidad la capacidad diferencial de productores arroceros ganaderos y citrícolas de incorporarse a un proyecto de inversión pública- privada.","palabras_clave":"Recursos hídricos|Distribución del agua|Estructura agraria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":462,"idioma_id":4,"titulo":"X-ray structure of the mature ectodomain of phogrin","resumen":"Abstract Phogrin\/IA-2b and ICA512\/IA-2 are two par-  alogs receptor-type protein-tyrosine phosphatases (RPTP)  that localize in secretory granules of various neuroendo-  crine cells. In pancreatic islet b-cells, they participate in the  regulation of insulin secretion, ensuring proper granulo-  genesis, and b-cell proliferation. The role of their cyto-  plasmic tail has been partially unveiled, while that of their  luminal region remains unclear. To advance the under-  standing of its structure?function relationship, the X-ray  structure of the mature ectodomain of phogrin (ME pho-   &#778;grin) at pH 7.4 and 4.6 has been solved at 1.95- and 2.01-A  resolution, respectively. Similarly to the ME of ICA512,  ME phogrin adopts a ferredoxin-like fold: a sheet of four  antiparallel b-strands packed against two a-helices.  Sequence conservation among vertebrates, plants and  insects suggests that the structural similarity extends to all  the receptor family. Crystallized ME phogrin is mono-  meric, in agreement with solution studies but in striking  contrast with the behavior of homodimeric ME ICA512.","palabras_clave":"INSULIN|SECRETORY GRANULE|DIABETES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":463,"idioma_id":4,"titulo":"Genetic characterization and clinical implications of human papillomavirus type 16 (HPV-16) variants from northeastern Argentina.","resumen":"BACKGROUND: &nbsp;Humanpapillomavirus type 16 (HPV16) plays a central role in the development ofcervical cancer. Worldwide studies indicate the existence of HPV16 variantsthat show different geographic distributions and oncogenic potential.OBJECTIVE: &nbsp;Ourgoal was to describe the genetic variation of HPV16 isolates identified inurban women with different grades of cervical lesions living in northeastern Argentina.STUDY DESIGN: &nbsp;We analyzed 116 HPV16-positive cervicalsamples (16 NLIM, 62 L-SIL, 16 H-SIL and 22 cervical cancer) from patientsattending health centers in Misiones (Argentina) during 2006-13. HPV16isolates were genetically characterized through PCR amplification and directsequencing of 364 bp within the long control region, and the resultingsequences classified into variants based on phylogenetic analysis (lineages A,B, C and D). A potential association between HPV16 variants and lesion gradewas evaluated through an odds ratio (OR) test. A temporal framework for theorigin of HPV16 variants was assessed through coalescence analysis (BEAST v1.7.5).RESULTS: &nbsp;Phylogeneticanalysis of HPV16 sequences showed that 92.1% of the samples clustered withlineage A, and 6.9% to lineage D. HPV16 variants from lineage D were morefrequently associated with high-grade lesions and cancer (HSIL+) than lineage Avariants at an OR of 13.8 (1.6-117.0). The time to most common recent ancestor(tMCRA) of all variants was 119,103 years before present (HPD95%=48,486-197,239), a date consistent with the time frame for modern humanevolution.CONCLUSION: &nbsp;Ourresults suggest that HPV16 variants from lineage D may represent an additionalrisk factor for the development of cervical cancer in women living innortheastern Argentina.This study provides new information about viral isolates present in Argentina thatwill contribute to the monitoring of HPV16 infection in the vaccine era.&nbsp;","palabras_clave":"CANCER|PAPILLOMAVIRUS|GENETICS|PHYLOGENY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":464,"idioma_id":4,"titulo":"Pesticide effects on crabs. How environmental concentrations of endosulfan and chlorpyrifos affect embryos.","resumen":"The objectives of this work were to evaluate the effects of environmentally relevant chlorpyrifos and endosulfan, concentrations in the incubation period, effective hatching and survival of embryos and neonates of the freshwater burrowing crab, Zilchiopsis collastinensis (Decapoda, Trichodactylidae). Both pesticides were prepared from commercial and technical grade products. Theexposure to about 100, 200, and 400 ng endosulfan L¡1, and 48, 240, and 1,200 ng chlorpyrifos L¡1 did not cause differences in the incubation period or in effective hatching but decreased survival of neonates, especially in the concentrations prepared from the technical grade product. Even if these concentrations are below the median lethal concentration (LC50) values for embryos, these caused a significant decrease in the survival of neonates, i.e. when crabs are outside the egg and not protected by chorion. The decrease in the neonate population caused by these concentrations, which could be found in the environment, might impact aquatic communities.","palabras_clave":"Agricultural pollution|crustaceans|embryos|neonates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":465,"idioma_id":4,"titulo":"3-Chlorotyramine Acting as Ligand of the D2 Dopamine Receptor. Molecular Modeling, Synthesis and D2 Receptor Affinity","resumen":"Abstract: We synthesized and tested 3-chlorotyramine as  a ligand of the D2 dopamine receptor. This compound displayed  a similar affinity by this receptor to that previously  reported for dopamine. In order to understand further the  experimental results we performed a molecular modeling  study of 3-chlorotyramine and structurally related compounds.  By combining molecular dynamics simulations  with semiempirical (PM6), ab initio and density functional  theory calculations, a simple and generally applicable procedure  to evaluate the binding energies of these ligands interacting  with the D2 dopamine receptors is reported here.  These results provided a clear picture of the binding interactions  of these compounds from both structural and energetic  view points. A reduced model for the binding pocket  was used. This approach allowed us to perform more accurate  quantum mechanical calculations as well as to obtain  a detailed electronic analysis using the Quantum Theory of  Atoms in Molecules (QTAIM) technique. Molecular aspects  of the binding interactions between ligands and the D2  dopamine receptor are discussed in detail. A good correlation  between the relative binding energies obtained from  theoretical calculations and experimental IC50 values was  obtained. These results allowed us to predict that 3-chlorotyramine  possesses a significant affinity by the D2-DR. Our  theoretical predictions were experimentally corroborated  when we synthesized and tested 3-chlorotyramine which  displayed a similar affinity by the D2-DR to that reported for  DA.","palabras_clave":"3-CHLOROTYRAMINE|MD SIMULATIONS|QTAIM ANALYSIS|D2 DOPAMINE RECEPTOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":466,"idioma_id":4,"titulo":"Defect formation and coarsening in hexagonal 2D curved crystals","resumen":"In this work we study the processes of defect formation and coarsening of two-dimensional (2D) curved crystal structures. These processes are found to strongly deviate from their counterparts in flat systems. In curved backgrounds the process of defect formation is deeply affected by the curvature, and at the onset of a phase transition the early density of defects becomes highly inhomogeneous. We observe that even a single growing crystal can produce varying densities of defects depending on its initial position and local orientation with regard to the substrate. This process is completely different from flat space, where grain boundaries are formed due to the impingement of different propagating crystals. Quenching the liquid into the crystal phase leads to the formation of a curved polycrystalline structure, characterized by complex arrays of defects. During annealing, mechanisms of geodesic curvature-driven grain boundary motion and defect annihilation lead to increasing crystalline order. Linear arrays of defects diffuse to regions of high curvature, where they are absorbed by disclinations. At the early stage of coarsening the density of dislocations is insensitive to the geometry while the population of isolated disclinations is deeply affected by curvature. The regions with high curvature act as traps for the diffusion of different structures of defects, including disclinations and domain walls.","palabras_clave":"block copolymer thin films"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":467,"idioma_id":4,"titulo":"Test for the Detection of the Retrograde Melting Phenomenon in Computed Solid-Fluid Equilibria of Binary Asymmetric Systems","resumen":"The phenomenon of retrograde melting at constant temperature takes place when a solid phase is melted, or made to disappear, upon compression. Analogously, retrograde melting at constant pressure happens when a solid phase is melted, or made to disappear, upon cooling. In this work, we propose a test that makes possible to establish for a calculated, already converged, binary solid-fluid equilibrium (SFE) point (of temperature TSFE, pressure PSFE, and fluid phase composition z2.), whether the behavior is regular or retrograde and, in case of retrograde behavior, whether the melting phenomenon is retrograde with respect to temperature, or to pressure, or to both. The test is based on evaluating, at TSFE and PSFE, the derivatives of the reduced tangent plane distance (tpd) with respect to temperature ( d tpd* \/ dT | P, z2)_SFE and pressure   ( d tpd* \/ d P| T, z2)_SFE , for a tested phase of composition z2, and a trial phase consisting of the pure heavy component in solid state at TSFE and PSFE. The distinguishing feature of the present test is that the derivatives ( d tpd* \/ dT | P, z2)_SFE  and ( d tpd* \/ d P| T, z2)_SFE are evaluated explicitly from the already converged SFE point, i.e., the present test does not require the computation of additional SFE points. Consequently, the test is fast and can be used for all points of a calculated SFE segment of an isopleth envelope. This leads to the eventual identification of points along the computed SFE segment where transitions from retrograde to regular behavior occur. We present results for a couple of highly asymmetric systems with the help of a model that uses an equation of state for describing the fluid phases, and a standard equation for describing the fugacity of the pure heavy component as a function of temperature and pressure.","palabras_clave":"SOLIDFLUID EQUILIBRIUM|RETROGRADE MELTING|BINARY EQUATION OF STATE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":469,"idioma_id":5,"titulo":"Extracción de Parámetros de un Panel Solar Utilizando Algoritmos Geneticos","resumen":"La obtención de un modelo que reproduzca fielmente las características eléctricas y térmicas de un panel solar, facilita el diseño de los sistemas electrónicos asociados a los arreglos fotovoltáicos. Es por ello que en este trabajo se propone la utilización de algoritmos genéticos para la extracción de los parámetros característicos del denominado modelo de un diodo de un panel solar. Con los parámetros encontrados se obtiene una curva corriente-tensión y se la compara con la curva ofrecida por el fabricante, de forma de verificar la validez del método.","palabras_clave":"Paneles solares|Extracción de parámetros|Algoritmos Genéticos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":471,"idioma_id":4,"titulo":"Bacterial communities in the rhizosphere of Vitis vinifera L. cultivated under distinct agricultural practices in Argentina","resumen":"Plants interact with a myriad of microbial  cells in the rhizosphere, an environment that is  considered to be important for plant development.  However, the differential structuring of rhizosphere  microbial communities due to plant cultivation under  differential agricultural practices remains to be  described for most plant species. Here we describe  the rhizosphere microbiome of grapevine cultivated  under conventional and organic practices, using a  combination of cultivation-independent approaches.  The quantification of bacterial 16S rRNA and nifH  genes, by quantitative PCR (qPCR), revealed similar  amounts of these genes in the rhizosphere in both  vineyards. PCR-DGGE was used to detect differences  in the structure of bacterial communities, including  both the complete whole communities and specific  fractions, such as Alphaproteobacteria, Betaproteobacteria,  Actinobacteria, and those harboring the  nitrogen-fixing related gene nifH. When analyzed by  a multivariate approach (redundancy analysis), the  shifts observed in the bacterial communities were  poorly explained by variations in the physical and  chemical characteristics of the rhizosphere. These  approaches were complemented by high-throughput  sequencing (67,830 sequences) based on the V6 region  of the 16S rRNA gene, identifying the major bacterial  groups present in the rhizosphere of grapevines:  Proteobacteria, Actinobacteria, Firmicutes","palabras_clave":"Bacterial communities|Cultivation|Cultivationindependent|Plant?microbe interactions|Rhizosphere microbiome|Organic management"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":472,"idioma_id":4,"titulo":"Negative differential resistance in porous silicon devices at room temperature","resumen":"We report a voltage controlled negative differential resistance (NDR) effect at room  temperature in two types of devices based on porous silicon (PS): thermally oxidized  porous silicon multilayer with Ag electrodes in a sandwich configuration (Ag\/c-Si\/PS\/Ag) and porous silicon single layer with Al electrodes in a coplanar configuration (Al\/PS\/Al). The NDR effect was observed in current-voltage characteristics and showed telegraphic noise. The NDR effects showed a strong dependence with temperature and with the surrounding atmospheric air pressure. The NDR occurrence was attributed to the blocking of conduction channels due to carrier trapping phenomena. We also experimentally demonstrate porous silicon devices exploiting the NDR effect, with potential applications as volatile memory devices.","palabras_clave":"Negative differential resistance|Porous silicon devices|Telegraphic noise|Coulomb repulsion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":473,"idioma_id":4,"titulo":"Specific methionine oxidation of cytochrome c in complexes with zwitterionic lipids by hydrogen peroxide: potential implications for apoptosis","resumen":"Cytochrome c (Cyt-c) has been previously shown to participate in cardiolipin (CL) oxidation and, therefore,in mitochondrial membrane permeabilization during the early events of apoptosis. The gain in this function has been ascribed to specific CL\/Cyt-c interactions. Here we report that the cationic protein Cyt-c is also able to interact electrostatically with the main lipid components of the mitochondrial membranes, the zwitterionic lipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), through the mediation of phosphate anions that bind specifically to amino groups in the surfaces of protein and model membranes. In these complexes, Cyt-c reacts efficiently with H2O2 at submillimolar levels, which oxidizes the sulfur atom of the axial ligand Met80. The modified protein is stable and presents significantly enhanced peroxidatic activity. Based on these results, we postulate that the rise of H2O2 concentrations to the submillimolar levels registered during initiation of the apoptotic program may represent one signaling event that triggers the gain in peroxidatic function of the Cyt-c molecules bound to the abundant PE and PC membrane components. As the activated protein is a chemically stable  species, it can potentially bind and oxidize important targets, such as CL.","palabras_clave":"citocromo c|peroxido de hidrogeno|sulfoxidación|espectrocopia raman"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":474,"idioma_id":4,"titulo":"Serogroup-specific bacterial engineered glycoproteins as novel antigenic targets for diagnosis of Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome","resumen":"Human infection with Shiga toxin-producing Escherichia coli (STEC) is a major cause of postdiarrheal hemolytic-uremic syndrome  (HUS), a life-threatening condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. E. coli  O157:H7 is the dominant STEC serotype associated with HUS worldwide, although non-O157 STEC serogroups can cause a similar  disease. The detection of anti-O157 E. coli lipopolysaccharide (LPS) antibodies in combination with stool culture and detection  of free fecal Shiga toxin considerably improves the diagnosis of STEC infections. In the present study, we exploited a bacterial  glycoengineering technology to develop recombinant glycoproteins consisting of the O157, O145, or O121 polysaccharide  attached to a carrier protein as serogroup-specific antigens for the serological diagnosis of STEC-associated HUS. Our results  demonstrate that using these antigens in indirect ELISAs (glyco-iELISAs), it is possible to clearly discriminate between STEC  O157-, O145-, and O121-infected patients and healthy children, as well as to confirm the diagnosis in HUS patients for whom the  classical diagnostic procedures failed. Interestingly, a specific IgM response was detected in almost all the analyzed samples, indicating  that it is possible to detect the infection in the early stages of the disease. Additionally, in all the culture-positive HUS  patients, the serotype identified by glyco-iELISAs was in accordance with the serotype of the isolated strain, indicating that these  antigens are valuable not only for diagnosing HUS caused by the O157, O145, and O121 serogroups but also for serotyping and  guiding the subsequent steps to confirm diagnosis.","palabras_clave":"recombinant glycoproteins|E. coli STEC|Hemolytic Uremic Syndrome|diagnosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":475,"idioma_id":4,"titulo":"Dietary intervention with Salvia hispanica (Chia) oil improves vascular function in rabbits under hypercholesterolaemic conditions","resumen":"The effects of dietary supplementation with Salvia hispanica (chia) oil on vascular function  in hypercholesterolaemic rabbit were examined. Rabbits were fed either regular diet (CD)  or 10% chia oil in regular diet or 1% cholesterol diet (HD) or diet containing 1% cholesterol  and 10% chia oil (HD-Ch) during 5?6 weeks. HD increased total cholesterol, LDL and  triacylglycerol levels. HD-Ch significantly attenuated the triacylglycerol rise and increased  alpha linolenic acid (ALA) levels. Aorta from hypercholesterolaemic rabbits exhibited an  impaired relaxation response to acetylcholine (Ach), reduced NO-release and increased  intima\/media ratio. Including chia oil in the HD partially normalized the response to Ach  and the intima\/media ratio, and totally restored the NO-release. In addition, dietary  supplementation with chia oil blunted the contractile response to angiotensin II and  noradrenaline. These findings suggest that increased ALA levels induced by dietary chia oil  could improve vascular function under hypercholesterolaemic conditions and therefore could  serve as a true functional food.","palabras_clave":"CHIA OIL|HYPERCHOLESTEROLAEMIA|VASCULAR DYSFUNCTION|ANGITENSINA II"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":476,"idioma_id":4,"titulo":"Study of Plastic Heterogeneity in a Low Carbon Steel Sheet by EBSD","resumen":"   The aim of this study is to analyze the development of plastic heterogeneity in low carbon steel sheets when they are subjected to different loading paths, typical of forming process operations. Nakajima type tests are performed and employed to determine the Forming Limit Curve. This study attempts to characterize, at polycrystalline level, the plastic heterogeneity and its gradients, enabling the definition of correlations between the dislocation structure, grain size and crystallographic orientations. Geometrically Necessary Dislocations (GND) is estimated by calculating the curvature tensor from the measured orientation field. The results are compared with the Kernel Average Misorientation factor (KAM), normally available in the TSL- OIM EBSD software. The Quantification of the distribution of disorientations in each grain is performed by evaluating the second-order central moment of crystal misorientations (Q tensor). Finally, the evaluation of the isotropic and anisotropic factors of the Q tensor and the distribution of the misorientation preferential axes allow characterizing the microstructure dependent on the applied loading, the grain size or the crystal orientation. ","palabras_clave":"HETEROGENEIDAD PLÁSTICA|LOW CARBON STEELS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":477,"idioma_id":5,"titulo":"Efecto del grado de reposo invernal de alfalfa (Medicago sativa L.) sobre el rendimiento de heno en el oasis norte de Mendoza","resumen":"La alfalfa es la forrajera más importante de Mendoza; representa el 4,1 % del área cultivada en la provincia y el 60 % de la superficie de cultivos forrajeros.  Las características del ambiente en el que se va a implantar el alfalfar condicionan el grado de reposo a seleccionar. La provincia de Mendoza no participa en la Red de Ensayos Territoriales de alfalfa del INTA y por lo tanto no se dispone de información precisa que nos permita elegir el grado de reposo invernal (GRI) de la cultivar a sembrar. Los objetivos de este trabajo fueron: identificar el o los grupos de reposo invernal que presenten mayor rendimiento de heno por año en las condiciones de cultivo del oasis norte de la provincia; determinar el número de cortes por año, la calidad del heno, y la persistencia de los distintos GRI. La experiencia se llevó a cabo en el campo experimental de la Facultad de Ciencias Agrarias, en la parcela de la cátedra  de Agricultura Especial; 33º 00? 30?? S y 68º 52? 32?? O, con un cultivar representativo de cada grupo de reposo invernal desde el 6 al 10. Se evaluaron los ciclos 2012-2013 y 2013-2014. No se detectaron diferencias de rendimiento de forraje en ningún ciclo; se realizaron 6 cortes por ciclo en los cinco GRI, la calidad estimada a partir de la relación hoja\/tallo no presentó diferencias entre cultivares en ningún ciclo de crecimiento, y la persistencia no presentó variaciones significativas.","palabras_clave":"ALFALFA|GRI|RENDIMIENTO|CALIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":480,"idioma_id":5,"titulo":"Evaluación de modelos hidrodinámicos para representar flujos en cauces naturales","resumen":"El flujo libre se presenta cuando los líquidos fluyen por la acción de la gravedad y solo están parcialmente confinados por un contorno sólido. En la predicción de las variables de flujo para diferentes condiciones tiene gran importancia el desarrollo de modelos y simulaciones numéricas hidrodinámicas con precisión adecuada que permiten la correcta planificación de obras. Se ha estudiado el uso de modelos analíticos en la solución de fenómenos de mecánica de los fluidos, que están basados en las leyes de conservación de masa, momento y energía. Según sea el grado de simplificación al que se pueda llegar, manteniendo el nivel de precisión y verificando un buen comportamiento de lo modelado respecto a la naturaleza, se tienen los esquemas hidrodinámicos unidimensionales, bidimensionales y tridimensionales. Las confluencias son ambientes complejos ya que la convergencia de flujos produce complicados patrones de movimiento de fluidos. En este trabajo se presenta la formulación, métodos de solución y metodologías en general para el desarrollo de modelos físicos y matemáticos en flujos a superficie libre. Para ello se estudió la confluencia del arroyo La Cañada y el río Suquía en la Ciudad de Córdoba.","palabras_clave":"MODELOS |HIDRODINÁMICOS|FLUJO|CAUCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":481,"idioma_id":5,"titulo":"Saliva como fluido de diagnóstico: Marcadores de destrucción periodontal","resumen":"La enfermedad periodontal es una infección crónica de origen bacteriano. La IL-1 y el TNF-&#945; son potentes  estimuladores de reabsorción ósea y fueron estudiados como biomarcadores de la enfermedad periodontal progresiva destructiva","palabras_clave":"ENFERMEDAD PERIODONTAL|SALIVA|BIOMARCADORES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":482,"idioma_id":4,"titulo":"A Fluorometric Enzymatic Assay for Quantification of Steryl Glucosides in Biodiesel","resumen":"Steryl glucosides (SG) are common contaminants in biodiesel that form precipitates, which form and cause problems due to fouling during transport and storage. Therefore, their quantification is necessary to assess the quality of this fuel. The methods currently available for SG analysis require expensive instrumentation, need a previous concentration step by solid-phase extraction (SPE) or are of limited use for the quantitative assessment.  We developed an enzymatic method for steryl glucosides quantification in biodiesel samples based on the hydrolysis of the glucoside catalyzed by a broadly specific beta glucosidase and the subsequent determination of the glucose released by the reaction. The method is non-expensive, sensitive and was adapted to 96-well format fluorescence plate reader, making it useful for the parallel assay of multiple samples. The enzymatic assay presented here represent a valuable tool for both quality control and the development of improved biodiesel production and purification procedures.","palabras_clave":"BIODIESEL|ESTERIL|GLUCOSIDOS|CUANTIFICACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":483,"idioma_id":4,"titulo":"A heuristic for the OD matrix adjustment problem in a congested transport network","resumen":"We study the Demand Adjustment Problem (DAP) associated to the urban traffic planning. The framework for the formulation of the DAP is mathematical programming with equilibrium constraints. In particular, if we consider the optimization problem equivalent to the equilibrium problem, the DAP becomes a bilevel  optimization problem. In this work we present a descent scheme based on the approximation of the gradient of the objective function of DAP.","palabras_clave":"TRAFFIC|ASSIGNMENT|ORIGIN|DESTINATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":485,"idioma_id":4,"titulo":"Comparison of toxicogenic and immunosuppressive capacity of Aspergillus fumigatus strains isolated from clinical and corn silage samples","resumen":"Aims: To compare clinical and environmental Aspergillus fumigatus strains ontheir toxicogenic and immunosuppressive capacity.Methods and Results: A total of 51 strains of A. fumigatus isolated fromclinical and corn silage samples were assayed. All A. fumigatus strains wereassayed for gliotoxin production, therefore strains with different gliotoxincapacities and isolated from different sources were selected and assayed fortheir effects on bovine macrophages and lymphocytes. Spore diffusates (SDs)obtained from all A. fumigatus strains were able to inhibit macrophagephagocytosys, regardless of their gliotoxin production capacity. However, mostbut not all strains were able to inhibit bactericidal activity. SDs from allA. fumigatus strains reduced lymphocytes viability. The heat treatment was notalways able to inhibit the negative effect on immune cells.Conclusions: There was no difference between clinical and environmentalisolates in their toxicogenic and immunosuppressive capacity. Gliotoxin wouldnot be responsible for the immunosuppressive activity observed by the assayedA. fumigatus strains. However, gliotoxin could be present in the SD, togetherwith some other substances.Significance and Impact of the Study: The results obtained suggest that anyenvironmental strain of A. fumigatus is a putative infectious strain. Preventionmeasures should be applied to control environmental Aspergillus conidia.","palabras_clave":"toxicogenic capacity|immunosuppressive capacity|Aspergillus fumigatus|clinical and corn silage samples"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":487,"idioma_id":4,"titulo":"The impact of Biopreservatives and Storage Temperature in the  Quality and Safety of Minimally Processed Mixed Vegetables for Soup","resumen":"BACKGROUND: The combined effects of bioactive agents (tea tree essential oil,propolis extract and gallic acid) and storage temperature on the microbiological and sensory quality of fresh cut mixed vegetables for soup (celery, leek and butternut squash) were studied with the objective of preserving its quality and safety.  RESULTS: Refrigeration temperature was confirmed as the main factor to limit the growth of spoilage and pathogenic microorganisms. Biopreservatives applied on mixed vegetables were effective only when combined with optimal refrigeration temperature (5 °C). Bioactive compounds showed slight effectiveness in controlling the microbiota  present in mixed vegetables although coliforms were greatly reduced by gallic acid and propolis treatments, achieving 0.5-2 log units reductions during storage. Also, these agents showed antimicrobial activity against endogenous E. coli and inoculated E. coli O157:H7, exerting bacteriostatic effect and reducing population counts in 0.9-1.2 log  CFU g-1 at 10 days of refrigerated storage. The combination of propolis treatment with refrigerated storage conditions effectively preserved the sensory quality and prolonged the sensory shelf life of fresh-cut mixed vegetables by 3 days.  CONCLUSION: The use of natural agents, as propolis extract, to preserve the quality and safety of mixed vegetables for soup might be an interesting option to adress the concerns of the consumer about the use of synthetic chemical antimicrobials potentially harmful for health.","palabras_clave":"BIOPRESERVATION   |SHELF LIFE|PATHOGEN CONTROL, |FRESH-CUT VEGETABLES |PROPOLIS|SENSORY ATRRIBUTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":488,"idioma_id":4,"titulo":"Effect of the urease-derived peptide Jaburetox on the central nervous system of Triatoma infestans (Insecta: Heteroptera)","resumen":"Background: Triatoma infestansis the main vector of Chagas´disease in Southern Cone countries. In triatomines,symptoms suggesting neurotoxicity were observed after treatment with Jaburetox (Jbtx), the entomotoxic peptide obtained from jackbean urease. Here, we study its effect in the central nervous system (CNS) of this species. Methods:Immunohistochemistry, Western blots, immunoprecipitation, two-dimensional electrophoresis, tandem mass spectrometry and enzymatic assays were performed. Results:Anti-Jbtx antibody labeled somata of the antennal lobe only in Jbtx-treated insects. Western blot assays of nervous tissue using the same antibody reacted with a 61 kDa protein band only in peptide-injected insects.Combination of immunoprecipitation, two-dimensional electrophoresis and tandem mass spectrometry identified UDP-N-acetylglucosamine pyrophosphorylase (UDP-GlcNAcP) as a molecular target for Jbtx. Theactivity of UDP-GlcNAcP increased significantly in the CNS of Jbtx-treated insects. The effect of Jbtx on the activity of nitric oxide synthase (NOS) and NO production was investigated as NO is a recognized messenger molecule in the CNS ofT. infestans. NOS activity and NO levels decreased significantly in CNS homogenates of Jbtx-treated insects. Conclusions:UDP-GlcNAcP is a molecular target of Jbtx. Jbtx impaired the activity ofT. infestansnitrergic system, which may be related with early behavioral effects. General Significance:We report that the CNS ofTriatoma infestansis a target for the entomotoxic peptide and propose that a specific area of the brain is involved. Besides potentially providing tools for control strategies of Chagas´ disease vectors our data may be relevant in variousfields of research as insect physiology, neurobiology and protein function.","palabras_clave":"Triatoma infestans  |Central nervous system|Canavalia ensiformis|Urease UDP-N-acetylglucosaminepyrophosphorylase|Nitric oxide"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":489,"idioma_id":4,"titulo":"Biodiversity of cactophilic microorganisms in western Argentina: community structure and species composition in the necroses of two sympatric cactus hosts","resumen":"The cactus-yeast-Drosophila system is a model system in evolutionary biology, and the  participating saprotrophic microorganisms represent one of the most thoroughly studied  microbial communities. However, much of the cactus-dominated regions of South America,  home to endemic versions of this classical system, remain understudied. A combined  morpho-physiological and molecular approach was employed to identify the fungal  members of the cactus-yeast-Drosophila system in western Argentina. We identified twenty  one species of saprotrophic organisms in the necroses of Opuntia sulphurea and Trichocereus  terscheckii in a region of sympatry, where both cacti are exploited by cactophilic Drosophila.  After excluding opportunistic isolates, we determined that the saprobe community of O.  sulphurea was composed of eight species (including the first consideration of filamentous  fungi as community members), whereas the community of T. terscheckii represented a  subgroup of the former. We explain this nested pattern by considering the physiological  and ecological attributes of both hosts and vectors involved.  ª 2014 Elsevier Ltd and The British Mycological Society. All rights reserved.","palabras_clave":"cactus|microroganismos|ecología|distribución"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":490,"idioma_id":4,"titulo":"Improving Arylsulfatase Activity Determination in Dried Blood Spots; Screening and Diagnostic Approaches for Maroteaux-Lamy Syndrome (MPS VI)","resumen":"Mucopolisaccharidosis type VI can be screened by measuring the lysosomal Arylsulfatase B  (ARSB) residual enzyme activity in dried blood spots (DBS) using synthetic substrates. However, we  have found experimental obstacles when determining ARSB activity with the fluorescent method due  to the significant quenching effect rendered by DBS components. In this work we adapted the methods  originally described by Chamoles et al. (2001) and Civallero et al. (2006), and put forward two distinct  approaches for ARSB activity quantification from DBS samples by measuring the 4-  Methylumbelliferone (&#946;-MU) fluorescence generated from the ARSB &#946;-MUS substrate. We  demonstrate the high throughput feasibility of a novel approach for measuring ARSB activities by  incorporating tailor-made calibration curves according to each patient´s DBS sample quenching  properties. The second method is used to calculate ARSB activities by measuring the fluorescence and  absorbance parameters in each reaction sample with a single DBS-free calibration curve. The  quantitative correlation between the DBS sample absorbance and its quenching effect can be used to  calculate predictive ARSB activities, and would serve as an affordable first tier screening test. The  method described herein demonstrates the critical importance of adapting the &#946;-MU calibration curves  to each patient´s unique DBS sample matrix and its positive impact on the accuracy and reliability of  ARSB activity measurements.","palabras_clave":"Neonatal screening|arylsulfatase|Maroteaux Lamy syndrome|diagnostic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":492,"idioma_id":4,"titulo":"?Alkaline and thermostable polygalacturonase from Streptomyces halstedii ATCC 10897 with applications in waste waters?","resumen":"Pectin degrading enzymes with polygalacturonase (PG) activity hydrolyze &#945;-(1,4) glycosidic bonds of polysaccharides present inhigher plants. In the current study one hundred bacterial strains were screenedfor extracellular PG activity using an inductive culture medium. Optimization of fermentation conditions for Streptomyceshalstedii ATCC 10897 was conducted using experimental designs. The maximumenzymatic activity obtained was 3.489 U\/mL and 98.0 % of viscosity reduction after 12 h of fermentation using soy peptone as unique source of carbon andnitrogen. PG from S. halstedii ATCC10897 showed high thermal stability, an approximate molecular weight of 48 kDaand its optimum conditions for catalytic reaction were 50 ºC and pH 12.0. This study reveals that alkaline PG is a useful enzyme for depectinization inalkaline pulping mill and papermaking waste waters. ","palabras_clave":"screening|culture medium design|fermentation optimizacion|waste water"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":493,"idioma_id":4,"titulo":"Analysis by Size Exclusion Chromatography of the Graft Terpolymer Present in MBS","resumen":"The molar mass distribution (MMD) and branching distribution (BD) of the graft terpolymer present in MBS (methyl methacrylate-butadiene-styrene, MMA-B-St) were estimated by size exclusion chromatography (SEC) with a series of three detectors: a UV photometer, a specific viscometer (SV), and a differential refractometer (DR). A solvent extraction procedure was employed to isolate the main MBS constituents: unreacted polybutadiene (PB), a PMMA-PS free copolymer (FC), and the PB-g-(PMMA-PS) graft terpolymer (GT). The FC was analyzed by UV + DR, yielding an almost uniform St mass fraction. The analysis of the GT involved the following assumptions: (i) the composition of the grafted branches coincides with that of the FC; (ii) the volumetric contractions of the molecules are represented by the Zimm?Stockmayer equations for randomly branched homopolymers; (iii) the low molar mass fraction exhibits a single branch per molecule; and (iv) the Mark?Houwink?Sakurada (MHS) parameters of the hypothetical homologous linear terpolymer are estimated by weighting the MHS constants of the PB and FC according to their mass fractions in the GT. The data treatment employed also enabled the branching exponent (&#949;) that relates the geometric and hydrodynamic contraction factors to be estimated, yielding &#949;&#8201;&#8776;&#8201;1.45.","palabras_clave":"SIZE EXCLUSION CHROMATOGRAPHY|GRAFT TERPOLYMER|MBS|BRANCHING EXPONENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":495,"idioma_id":4,"titulo":"An experimental and TD-DFT theoretical study on the photophysical properties of Methylene  Violet Bernthsen","resumen":"We revisited the photophysics the Methylene Violet (MV) Bernthsen dye in aprotic solvents to rationalize both its peculiar solvatochromism, which cannot be explained by the standard solvatochromic empirical models, and the large dependence of its excited states decay kinetics upon changes on the polarity of the medium.    To this end, MV singlet and triplet excited states were characterized by stationary and time-resolved absorption and emission techniques. The experimental information was combined with a detailed theoretical study using TD-DFT to characterize not only the emitting states but also all dark states which would play a role in determining the fate and properties of the experimentally populated excited states. It is concluded that owning to both the high permanent dipole and polarizability of MV, singlet and triplet excited states are stabilized by the medium to a very different extent, leading to an unusual solvatochromism and decay kinetics.","palabras_clave":"cromóforo pull-push|TD-DFT|solvatocromismo|cinética estados excitados"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":498,"idioma_id":4,"titulo":"On the origin of white photoluminescence from ZnO nanocones\/porous silicon heterostructures at room temperature","resumen":"ZnO nanocones were grown on porous silicon (PS) by vapor transport at different temperatures and O2 flow rates without metal nanocatalysts. The ZnO\/PS heterostructures were studied by electron microscopy, and by photoluminescence and electron resonance (EPR) spectroscopies. Samples emitted strong white PL, opening potential application for white light illumination. The photoluminescence spectra were found to include five main components centered at 1.84, 2.06, 2.30, 2.48 and 3.31 eV. The components at 2.48 and 2.06 eV were related to oxygen vacancies in ZnO, that at 2.3 eV to Zn vacancies and the one at 1.84 eV to the PS substrate. The low excitonic emission intensity at 3.31 eV and the observed rough ZnO nanocone morphology suggest the presence of surface trap states. EPR shows a g &#8764; 2.006 line attributed to Zn divacancies.The absence of the g = 1.96 line, attributed to conduction band electrons, suggests strong carrier depletion.","palabras_clave":"ZnO nanocones|Photoluminescence|Electron paramagnetic resonance|White emission|Porous silicon"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":499,"idioma_id":4,"titulo":"The Neocomian of Chachahuén (Mendoza, Argentina): Evidence of a broken foreland associated with the Payenia flat-slab","resumen":"Isolated marine sedimentary Lower Cretaceous deposits crop out in the foreland of the Neuquen Basin, west-central Argentina. They are the result of an anomalous uplift of the Sierra de Chachahuen in the far foreland region. These outcrops are assigned to the Agrio Formation based on their rich fossil contents. In particular, the study reveals a unique outcrop of continental facies along the eastern proximal margin of the basin that were known only from core wells, and constitutes the first exposed evidence at the surface. These deformed deposits are 70 km from the Andean orogenic front and present 2 km of local uplift produced by high-angle basement reverse faults that reactivated a previous Early Mesozoic rift system. The increase in compression was related to the decrease in the subduction angle. This fact, together with the expansion of the magmatic arc, controlled the Chachahuen calc-alkaline Late Miocene volcanic centre and the uplift of the Mesozoic deposits in the foreland. This broken foreland was associated with localized heating of the Miocene volcanic centre that produced the rising of the brittle-ductile transitions. This fact weakens the foreland area, which was broken by compression during the development of the Payenia flat-slab.","palabras_clave":"NEOCOMIAN|CHACHAHUEN|MENDOZA|PAYENIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":500,"idioma_id":5,"titulo":"EFECTO DEL RETARDO PRENATAL DE CRECIMIENTO Y LA SUBNUTRICION POSTNATAL EN EL CRECIMIENTO CRANEOFACIAL","resumen":"El objetivo fue analizar en animales con retardo prenatal de crecimiento (RPC) el efecto de la subnutrición proteico-calórica lactacional y postlactacional sobre la morfología craneofacial, particularizando en el crecimiento de los componentes funcionales neural y facial. Ratas Wistar fueron divididas en los grupos: Control, RPC (inducido por ligamiento parcial de ambas arterias uterinas el día 15 de gestación) y Sham-operado (con igual técnica quirúrgica que RPC aunque sin ligamiento de las arterias). A su vez, el grupo RPC se dividió en: (a) crías lactantes de madres con nutrición normal y a partir del destete alimentadas ad-libitum y (b) crías lactantes de madres con restricción alimentaria del 25% y a partir del destete alimentadas con el 50% de lo consumido por un animal control. Se tomaron radiografías a las edades 1, 21, 42, 63 y 84 y se midieron longitud, ancho y altura de los componentes neural y facial. Se calcularon los índices volumétricos neural y facial y morfométrico neurofacial. Se aplicaron ANOVA y pruebas post-hoc y calcularon diferencias porcentuales entre medias. Los resultados permitieron concluir que el estrés primario ocurrido durante la vida intrauterina resulta crítico en lo inmediato y en la vida postnatal, ya que aún mediando normonutrición postnatal el retardo de crecimiento perdura. Además, cuando al estrés prenatal le continúa restricción nutricional postnatal los efectos adversos son aditivos provocando retardo del crecimiento aún mayor. Finalmente, mientras que el componente neural es más resistente a las deficiencias nutricionales, el facial presenta mayor plasticidad hecho que se evidencia en cambios de forma.","palabras_clave":"crecimiento craneofacial|desnutrición pre y postnatal|craneometría funcional"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":501,"idioma_id":4,"titulo":"FLUORIDE ALTERS CONNEXIN EXPRESSION IN RAT INCISOR PULP","resumen":"Objective: Connexins (Cxs) are important to control growth and cell differentiation of dentaltissues. The aim ofthe present study was to assess the impact of chronic exposure to sodiumfluoride (NaF) on Cxs expression and alkaline phosphatase (ALP) activity in dental pulp, andon morphometric parameters of adult rat mandible and incisors.Design: Three groups of male Wistar rats (22 days-old) were given water containing: (a)0.3 mg\/L (Control), (b) 10 mg\/L and (c) 50 mg\/L of NaF for eight weeks. Incisor pulp homogenateswere prepared for determination of Cx32, Cx43 and Cx45 gene expression, usingsemi-quantitative RT-PCR, and of ALP activity. Morphometric parameters of mandible andincisors were determined on radiographs.Results: Cx43 gene expression increased with exposure to NaF in a dose-dependent manner.Cx32 mRNA levels were higher than controls in the 10 mg\/L NaF group only; Cx45 mRNAlevels were lower in groups given 10 and 50 mg\/L of NaF than in controls. ALP activity washigher in both high-NaF dose groups compared to the control group ( p < 0.05). Lower incisordiameter was lower in the 50 mg\/L NaF than in the control group (p < 0.01). None of themandibular growth parameters were affected by NaF treatment.Conclusion: Our results showed that fluorotic alterations in rat incisor were associated withincreased Cx43 expression and ALP activity, as well as with changes in the expressionpattern of different Cxs in pulp tissue. The observed changes may have a stimulating effecton dentin mineralization.# 2014 Elsevier Ltd","palabras_clave":"FLUORIDE|CONNEXINS|DENTAL PULP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":502,"idioma_id":4,"titulo":"Quantitative structure activity relationship and binding investigation of N-alkyl glycine amides as inhibitors of Leukotriene A4 hydrolase","resumen":"The leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc enzyme that catalyzes the final (rate-limiting) step in the synthesis of leukotriene B4 (LTB4), which is involved in several diseases. Many pharmaceutical attempts to exploit the LTA4H\/LTB4 pathway have been unsatisfactory, hence, the development of new inhibitory drugs is essential. This paper describes the generation of a quantitative structure--activity relationship (QSAR) model on a series of 50 N-alkyl glycine amides with experimentally defined IC.sub.50. In addition, the optimized molecular structures of the inhibitors were docked into the active site of the enzyme to identify the enzyme-ligand interactions and quantify the estimated free energy of binding (IG.sub.bind). A simple four-descriptor QSAR model with high predictive capacity was obtained. The statistic parameters of the model are: regression coefficient (R.sub.test) of 0.714 and a standard deviation (S.sub.test) of 0.696. The predicted inhibitory activity of 85 new N-alkyl glycine amides compounds was obtained with this QSAR model and these compounds were docked into LTA4H. Ten of the compounds present predicted IC.sub.50 values lower than 10 nM and binding poses and affinity values similar to the natural ligand (leukotriene A4), turning them into suitable candidates for experimental assays.","palabras_clave":"INHIBITORY ACTIVITY |LEUKOTRIENE A4 HYDROLASE|MOLECULAR DOCKING|N-ALKYL GLYCINE AMIDES|QSAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":503,"idioma_id":4,"titulo":"Precision phenotyping of imidazolinone-induced chlorosis in sunflower","resumen":"Chlorosis level is a useful parameter to assess imidazolinone resistance in sunflower (Helianthus annuus L.).  The aim of this study was to quantify chlorosis through two different methods in sunflower plantlets treated  with imazapyr. The genotypes used in this study were two inbred lines reported to be different in their resistance  to imidazolinones. Chlorosis was evaluated by spectrophotometrical quantification of photosynthetic  leaf pigments and by a bioinformatics-based color analysis. A protocol for pigment extraction was presented  which improved pigment stability. Chlorophyll amount decreased significantly when both genotypes were  treated with 10 &#956;M of imazapyr. Leaf color was characterized using Tomato Analyzer® color test software. A  significant positive correlation between color reduction and chlorophyll concentration was found. It suggests  that leaf color measurement could be an accurate method to estimate chlorosis and infer chlorophyll levels in  sunflower plants. These results highlight a strong relationship between imidazolinone-induced chlorosis and  variations in leaf color and in chlorophyll concentration. Both methods are quantitative, rapid, simple, and  reproducible. Thus, they could be useful tools for phenotyping and screening large number of plants when  breeding for imidazolinone resistance in this species","palabras_clave":"Carotenoids|Chlorophylls|Chlorosis|color analysis software|Helianthus annuus L.|sunflower"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":504,"idioma_id":5,"titulo":"Diferentes lecturas de la noción lacaniana de identificación con el síntoma","resumen":"Continuando con la investigación de las transformaciones que Lacan impuso a los conceptos de síntoma y de identificación a lo largo de su enseñanza, nos proponemos ahora examinar las consecuencias clínicas de esas transformaciones, en especial la noción de ?identificación con el síntoma? formulada por Lacan en su Seminario 24, la cual ha quedado sujeta a diversas interpretaciones. El trabajo constata en primer término el desconcierto inicial de los estudiosos de su obra, quienes señalaron su carácter paradójico por reunir términos que resultaban antinómicos. A continuación, se indaga y delimita diferentes lecturas e interpretaciones de esta noción elaboradas por los discípulos de Lacan, muchas veces adoptando posiciones contrarias entre sí. La exposición las distribuye en dos vertientes: las diferencias que provienen del modo en que se concibe la identificación y, por otra parte, las que se originan en las diversas maneras de entender los conceptos de síntoma y de sinthome.","palabras_clave":"IDENTIFICACIÓN|SÍNTOMA|SINTHOME"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":506,"idioma_id":4,"titulo":"Mycobacterium bovis infection in a horse with granulomatous enterocolitis","resumen":"A 2-year-old dappled Percheron horse had a wasting condition that did not respond to antibiotic treatments and ultimately resulted in death. Thickening of the wall of the large colon and enlargement of the mesenteric lymph nodes were observed at postmortem examination, along with the presence of pinpoint whitish foci in the liver. Microscopic examination of affected tissues revealed diffuse chronic granulomatous enterocolitis, granulomatous mesenteric lymphadenitis, and multifocal granulomatous hepatitis. The DNA extracted from paraffin-embedded intestinal and lymph node samples was analyzed using both a polymerase chain reaction (PCR) assay and PCR?restriction endonuclease analysis and demonstrated the presence of Mycobacterium bovis.","palabras_clave":"ARGENTINA|HORSE|MYCOBACTERIUM BOVIS|TUBERCULOSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":507,"idioma_id":5,"titulo":"Hacia una genealogía del 'Buen Vivir'. Contribuciones desde el Análisis  Materialista del Discurso'","resumen":"El presente trabajo propone un análisis de algunas de las memorias discursivas de los actuales debates del buen vivir de Ecuador y Bolivia. Así, en una primera parte revisaremos las resonancias discursivas entre los recientes Planes de Desarrollo de Bolivia y de Ecuador y los debates latinoamericanos que se sucedieron entre 1968-1975, alrededor del diagnóstico sobre los 'límites del desarrollo'. En particular, analizamos los sentidos de 'desarrollo', 'población', 'recursos naturales', 'medio ambiente' y 'consumo'. El trabajo busca realizar una contribución a un asunto central para el problema de la gubernamentalidad contemporánea, que es la relación entre naturaleza y desarrollo. Pero, además, introduce una serie de elementos pocos frecuentes en el análisis de discurso, destacando la importancia de la 'controversia' y 'heterogeneidad' a partir de una mirada teórica y también política.","palabras_clave":"BUEN VIVIR|DESARROLLO SUSTENTABLE|HETEROGENEIDADES DISCURSIVAS|GENEALOGIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":508,"idioma_id":4,"titulo":"Search for H&#8594;&#947;&#947; produced in association with top quarks and constraints on the Yukawa coupling between the top quark and the Higgs boson using data taken at 7 TeV and 8 TeV with the ATLAS detector","resumen":"A search is performed for Higgs bosons produced in association with top quarks using the diphoton decay mode of the Higgs boson. Selection requirements are optimized separately for leptonic and fully hadronic final states from the top quark decays. The dataset used corresponds to an integrated luminosity of 4.5 fb&#8722;1 of proton-proton collisions at a center-of-mass energy of 7 TeV and 20.3 fb&#8722;1 at 8 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No significant excess over the background prediction is observed and upper limits are set on the tt¯H production cross section. The observed exclusion upper limit at 95% confidence level is 6.7 times the predicted Standard Model cross section value. In addition, limits are set on the strength of the Yukawa coupling between the top quark and the Higgs boson, taking into account the dependence of the tt¯H and tH cross sections as well as the H&#8594;&#947;&#947; branching fraction on the Yukawa coupling. Lower and upper limits at 95% confidence level are set at -1.3 and +8.0 times the Yukawa coupling strength in the Standard Model.","palabras_clave":"ALTAS ENERGIAS|HIGGS|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":509,"idioma_id":4,"titulo":"Kinetics of human sperm acrosomal exocytosis","resumen":"The acrosome reaction is a unique event in the lifespan of sperm characterized by the exocytosis of the acrosomal content and the release of hybrid vesicles formed by patches of the outer acrosomal membrane and the plasma membrane. This unique regulated exocytosis is mediated by essentially the same membrane fusion machinery present in neuroendocrine cells. However, whereas secretion in neuroendocrine cells occurs in less than a second, the acrosome reaction is normally assessed after several minutes of incubation with inducers. In this report, we measured the kinetics of human sperm exocytosis triggered by two stimuli (calcium ionophore and progesterone) by using electron microscopy and three different approaches based on the incorporation of fluorescent Pisum sativum agglutinin into the acrosome upon opening of fusion pores connecting the extracellular medium with the acrosomal lumen. The results with the different methods are consistent with a slow kinetics (t½ = 14 min). We also manipulated the system to measure different steps of the process. We observed that cytosolic calcium increased with a relatively fast kinetics (t½ = 0.1 min). In contrast, the swelling of the acrosomal granule that precedes exocytosis was a slow process (t½ = 13 min). When swelling was completed, the fusion pore opening was fast (t½ = 0.2 min). The results indicate that acrosomal swelling is the slowest step and it determines the kinetics of the acrosome reaction. After the swelling is completed, the efflux of calcium from intracellular stores triggers fusion pores opening and the release of hybrid vesicles in seconds.","palabras_clave":"acrosomal swelling|acrosome reaction|fusion pore| regulated exocytosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":510,"idioma_id":4,"titulo":"Stabilization of refrigerated avocado pulp: Effect of Allium and Brassica extracts on enzymatic browning","resumen":"The aim of this paper was to study the effectiveness of Allium and Brassica extracts to inhibit the evolution of enzymatic browning of avocado pulp tissue stored at refrigeration temperature (4 C). Color parameters and mathematical modeling were employed to determine browning kinetics. In general, the addition of Allium extracts to avocado pulp was more effective in delaying luminosity decrease during the first days of storage, compared to Brassica. Scallion, onion, white cabbage and cauliflower inhibited polyphenol oxidase (PPO), and avocado paste, could be preserved for more than 30 days. Brussels sprouts treatment generated the highest browning kinetic constant (0.86) and conserved acceptable color for less than 10 days. Scallion and garlic showed the great antibrowning indexes (0.96 and 0.77 respectively) considering L* decrease. Multivariate analysis indicated that vegetable extracts tested could be grouped  by variety according to polyphenol content, and by their influence on PPO activity. The results allow the conclusion that polyphenol content of vegetables extracts influence the change of color variables during the first days of storage, while PPO activity influence these parameters in the last period of refrigeration.","palabras_clave":"Allium|Brassica|PPO|Avocado|Browning"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":511,"idioma_id":4,"titulo":"Genetic diversity of Chlamydia among captive birds from central Argentina","resumen":"To study the occurrence of Chlamydia spp. and their genetic diversity, we analysed 793 cloacal swabs from 12 avian orders, including 76 genera, obtained from 80 species of asymptomatic wild and captive birds that were examined with conventional nested polymerase chain reaction and quantitative polymerase chain reaction. Chlamydia spp. were not detected in wild birds; however, four species (Chlamydia psittaci, Chlamydia pecorum, Chlamydia pneumoniae and Chlamydia gallinacea) were identified among captive birds (Passeriformes, n = 20; Psittaciformes, n = 15; Rheiformes, n = 8; Falconiformes n = 2; Piciformes n = 2; Anseriformes n = 1; Galliformes n = 1; Strigiformes n = 1). Two pathogens (C. pneumoniae and C. pecorum) were identified simultaneously in samples obtained from captive birds. Based on nucleotide-sequence variations of the ompA gene, three C. psittaci-positive samples detected were grouped into a cluster with the genotype WC derived from mammalian hosts. A single positive sample was phylogenetically related to a new strain of C. gallinacea. This report contributes to our increasing understanding of the abundance of Chlamydia in the animal kingdom.","palabras_clave":"Chlamydia|Birds|Genetic diversity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":512,"idioma_id":4,"titulo":"Biogeomorphically driven salt pan formation in Sarcocornia-dominated salt-marshes","resumen":"Salt-marshes are under increasing threat, particularly from sea-level   rise and increased wave action associated with climate change. The   development and stability of these valuable habitats largely depend on   complex interactions between biotic and abiotic processes operating at   different scales. Also, interactions between biotic and abiotic   processes drive internal morphological change in salt-marshes. In this   paper we used a biogeomorphological approach to assess the impact of   biological activities and interactions on salt pan formation in Sarcocornia-dominated   salt marshes. Salt pans represent a key physiographic feature of   salt-marshes and recent studies hypothesized that biogeomorphic   processes could be related to salt pan formation in SW Atlantic   salt-marshes. The glasswort Sarcocornia perennis is one of the   dominant plants in the salt-marshes of the Bahía Blanca Estuary   (Argentina) where they form patches up to 8&nbsp;m in diameter. These   salt-marshes are also inhabited in great densities by the burrowing crab   Neohelice (Chasmagnathus) granulata whose bioturbation rates are among the highest reported for salt-marshes worldwide. A set of biological interactions between N. granulata and S. perennis   appears to be responsible for salt pan development in these areas which   has not been described elsewhere. The main objective of this work was   to determine the ecological interactions occurring between plants and   crabs that lead to salt pan formation by using field-based sampling and   manipulative experiments. Our results showed that S. perennis   facilitated crab colonization of the salt-marsh by buffering otherwise   stressful physical conditions (e.g., temperature, desiccation). Crabs   preferred to construct burrows underneath plants and, once they reach   high densities (up to 40 burrows&nbsp;m-2), the sediment   reworking caused plant die-off in the central area of patches. At this   state, the patches lose elevation and become depressed due to the   continuous bioturbation by crabs. Thus, salt pans are generated in this   case by a set of biogeomorphic processes that include pure ecological   interactions such as plant facilitation of crab settlement and also   indirect negative effects of crabs on plant survival. Furthermore, crab   bioturbation affects sediment structure due to concentration of   burrowing activity under plant canopies promoting elevation loss and   leading, after a few years, to salt pan formation in a previously   vegetated substrate.","palabras_clave":"BIOGEOMORPHOLOGY|ECOMORPHODYNAMICS|SALT MARSHES|SALT PANS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":513,"idioma_id":5,"titulo":"Memoria colectiva e historia universal: figuras relevantes en estudiantes de psicología","resumen":"Los estudios en memoria colectiva postulan que las percepciones, las emociones y las intenciones de los individuos tienen un impacto social que va más allá de lo interpersonal e individual (Páez et al., 2007). La historia se invoca como una reserva simbólica que permite construir una identidad personal y grupal (Liu &amp; Hilton, 2005). El objetivo del presente trabajo es explorar en las representaciones sociales de la historia a partir de las figuras que un grupo de estudiantes menciona como más importantes al momento de contar la historia universal, la valoración que de ellas hacen y analizar probables  posicionamientos diferenciales. Se utilizó un cuestionario auto-administrado, versión modificada del desarrollado por Liu et al. (2005) a una muestra intencional compuesta por 144 estudiantes de psicología. Los resultados muestran a líderes políticos como los personajes más nombrados, junto a promotores de la paz y representantes del ámbito científico.","palabras_clave":"REPRESENTACIONES SOCIALES|HISTORIA UNIVERSAL|PERSONAJES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":518,"idioma_id":4,"titulo":"Administration of caseinomacropeptide-enriched extract to mice enhances the calcium content of femur in a low-calcium diet","resumen":"Caseinomacropeptide (CMP) is the 64 C-terminal amino acid residue of &#954;-casein, formed by chymosin cleavage during cheese manufacture. This study examined the effects of oral administration of a CMP-enriched extract (CMPEE), obtained from a local dairy plant, on the Ca content of mouse femurs. Animals received low (0.1%, w\/v), normal (0.5%, w\/v) or high (1.2%, w\/v) Ca diet for 3 or 8 weeks and CMPEE diluted (1:10) in their drinking water. No significant differences in Ca content were observed in faeces, kidney, urine or blood serum compared with control animals. The oral administration of CMP to mice significantly enhanced the Ca content in femur under a low-Ca diet model, especially during the period of full body development (3 weeks), in which case a significant 12% Ca increase was observed. These findings pave the way for further studies aimed at supplementing infant food with industrially-obtained CMP-enriched extract for enhanced bone health.","palabras_clave":"CASEINOMACROPEPTIDE|CALCIUM|MICE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":519,"idioma_id":4,"titulo":"Withanolides from three species of the genus Deprea (Solanaceae). Chemotaxonomical considerations","resumen":"Nine withanolides were isolated from the aerial parts of Deprea bitteriana, D. cuyacensis, and D. zamorae. Deprea bitteriana yielded two withaphysalins, D. cuyacensis gave two 13,14-seco withaphysalins, while D. zamorae yielded five physangulidins. New compounds were fully characterized by a combination of spectroscopic methods (1D and 2D NMR and MS). All compounds isolated from Deprea bitteriana and D. cuyacensis were obtained as epimeric mixtures at C-18. The structure of the physangulidin D was confirmed by X-ray diffraction analysis. The skeletons found in this research support the taxonomical position of the genus Deprea in the tribe Physalideae.","palabras_clave":"DEPREA|SOLANACEAE|WITHANOLIDES|CHEMICAL MARKERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":521,"idioma_id":4,"titulo":"Insights into the mechanism of the reaction between Hydrogen sulfide and peroxynitrite","resumen":"Hydrogen sulfide and peroxynitrite are endogenously generated molecules that participate in biologi-cally relevant pathways. A revision of the kinetic features of the reaction between peroxynitrite andhydrogen sulfide revealed a complex process. The rate constant of peroxynitrite decay, (6.65 7 0.08) Â10 3 M À 1 s À 1 in 0.05 M sodium phosphate buffer (pH 7.4, 37 1C), was affected by the concentration ofbuffer. Theoretical modeling suggested that, as in the case of thiols, the reaction is initiated by thenucleophilic attack of HS À on the peroxide group of ONOOH by a typical bimolecular nucleophilicsubstitution, yielding HSOH and NO 2 À . In contrast to thiols, the reaction then proceeds to the formationof distinct products that absorb near 408 nm. Experiments in the presence of scavengers and carbondioxide showed that free radicals are unlikely to be involved in the formation of these products. Theresults are consistent with product formation involving the reactive intermediate HSSH and its fastreaction with a second peroxynitrite molecule. Mass spectrometry and UV?Vis absorption spectrapredictions suggest that at least one of the products is HSNO 2 or its isomer HSONO","palabras_clave":"peroxynitrite|H2S"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":522,"idioma_id":5,"titulo":"'La agricultura familiar en el marco de los programas de desarrollo rural del FIDA en el norte argentino (1991-2014)","resumen":"El propósito general de este artículo es describir y analizar los modos de concebir al agricultor familiar como sujeto de las políticas y programas de desarrollo rural. Partiendo del supuesto de que el pequeño productor o agricultor familiar posee un rol protagónico en los procesos vinculados con el desarrollo rural, en este trabajo se intentará comprender cómo ha variado la concepción del mismo en la continuidad de cinco programas de desarrollo rural financiados por el Fondo Internacional de Desarrollo Agrícola (FIDA) en Argentina. El tratamiento de esta temática en el marco de dichos programas nos permitirá dar cuenta de momentos diferentes de contextualización de la problemática de la agricultura familiar y el modo de generar políticas para este sector de la población rural. Para la realización de este trabajo se presenta un encuadre metodológico de tipo cualitativo con un diseño flexible a partir de diversas fuentes documentales primarias (documentos de los programas, informes de gestión, etc.) y entrevistas a informantes calificados (funcionarios que han participado de la gestión y administración de los mismos).","palabras_clave":"AGRICULTURA FAMILIAR|DESARROLLO RURAL|FIDA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":523,"idioma_id":4,"titulo":"Stress-triggered signaling affecting survival or suicide of Streptococcus pneumoniae","resumen":"Streptococcus pneumoniae is a major human pathogen that can survive to stress conditions, such as the acidic environment of inflammatory foci, and tolerates lethal pH through a mechanism known as the acid tolerance response. We previously described that S. pneumoniae activates acidic-stress induced lysisin response to acidified environments, favoring the release of cell wall compounds, DNA and virulence factors.Here, we demonstrate that F0F1-ATPase is involved in the response to acidic stress. Chemical inhibitors (DCCD, optochin) of this proton pump repressed the ATR induction, but caused an increased ASIL. Confirming these findings, mutants ofthe subunit c ofthis enzyme showed the same phenotypes as inhibitors.Importantly, we demonstrated that F0F1-ATPase and ATR are necessary for the intracellular survival of the pneumococcus in macrophages.Alternatively, a screening of two-component system (TCS) mutants showed that ATR and survival in pneumocytes were controlled in contrasting ways by ComDE and CiaRH, which had been involved in the ASIL mechanism. Briefly, CiaRH was essential for ATR (ComE represses activation) whereas ComE was necessary for ASIL (CiaRH protects against induction). They did not regulate F0F1-ATPase expression, but control LytA expression on the pneumococcal surface.These results suggest that both TCSs and F0F1-ATPase control a stress response and decide between a survival or a suicide mechanism by independent pathways, either in vitro or in pneumocyte cultures. This biological model contributes to the current knowledge about bacterial response under stress conditions in host tissues, where pathogens need to survive in order to establish infections.","palabras_clave":"Streptococcus pneumoniae|two-component systems|stress response|intracellular"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":527,"idioma_id":4,"titulo":"Awareness of zoonoses in freshmen entering the veterinary school","resumen":"In veterinary practice, the risk of zoonotic infections starts in College, when students are exposed to animals, and laboratory assignments. The objective of this study was to estimate awareness of zoonoses in a cohort of freshmen at the Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, Santa Fe (Argentina). A cross sectional study was conducted using a structured questionnaire in all students attending an introductory course (N= 179) on April, 2012. Data analysis included descriptive statistics and &#967;2. Zoonoses most frequently mentioned by students were rabies, scabies, tuberculosis and leptospirosis. Rural residence was associated with the recognition of ringworm (P= 0.0136), tuberculosis (P= 0.0302), leptospirosis (P= 0.0205) and hydatidosis (P= 0.0167) as zoonoses. Males showed higher awareness of trichinosis (P= 0.0025), tuberculosis (P= 0.0286), anthrax (P= 0.0035), and brucellosis (P= 0.0038) than females. Awareness of susceptible species and means of transmission varied among all zoonoses. These results reinforce the need for early exposure of veterinary students to occupational health and biosafety practices.","palabras_clave":"ZOONOTIC INFECTIONS|HYGIENE|VETERINARY STUDENTS|WORK SECURITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":528,"idioma_id":4,"titulo":"Responses of two sympatric sand lizards to exotic  forestations in the coastal dunes of Argentina: some  implications for conservation","resumen":"Context. Exotic forestations may modify habitat quality, affecting native animal populations that require specific microhabitats to remain viable.  Aims. We determined whether abundances and body condition of the lizard species Liolaemus wiegmannii and L. multimaculatus differed between forested and non-forested dunes. We also examined what environmental attributes are important in explaining the potential differences.  Methods. We sampled six sites of 300 ha each. Three of these sites had original vegetation and three were forested with exotic Acacia longifolia. We traced 120 transects per site searching for lizards.  Key results. Lizards were two times more abundant in non-forested sites than in sites covered by acacia trees (even as low as a fourth of the area). Sites with high densities of acacia (78% of coverage) had the lowest abundance of lizards. In forested sites, the snout?vent length of L. wiegmannii was 10% smaller and relative body mass 22% lower than in nonforested sites. We found no differences in the body size of L. multimaculatus.   Conclusions. The replacement of the native vegetation by A. longifolia has negative effects on lizard species, representing a substantial threat to L. wiegmannii and particularly to L. multimaculatus, a threatened status species.  Structural and thermal characteristics of the non-forested sites seemed to be more favourable for the abundance and body condition, whereas the dense vegetation and the low temperatures on the forested sites might explain the lower presence of lizards.  Implications. We recommend that before the implementation of future forestation plans in the pampasic coastal dunes, the deleterious consequences that this practice generates on native lizard fauna must be considered. When necessary, we  recommend that A. longifolia be planted so that the coverage does not exceed a quarter of the total area, so as to prevent the formation of continuous (or closed) forest patches and to maintain the structural heterogeneity of the habitat that these lizards need to survive. In the most affected areas, eradication and control strategies may help reduce the advancement of this exotic plant over the areas intended for conservation.","palabras_clave":"DUNES|EXOTIC PLANTS|GRASSLANDS|LIOLAEMUS|LIZARD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":529,"idioma_id":4,"titulo":"Assessment of a biofilm-based culture system within zero water exchange on water quality and on survival and growth of the freshwater shrimp Neocaridina heteropoda heteropoda","resumen":"DRA. V. E. VIAU ES INVESTIGADORA ASISTENTE BAJO DIRECCIÓN LS LÓPEZ GRECO16-Dec-2014Dear Dr. VIAU:It is a pleasure to accept your manuscript entitled 'Assessment of a biofilm-based culture system within zero-water exchange on water quality and on survival and growth of the freshwater shrimp Neocaridina heteropoda heteropoda.' in its current form for publication in Aquaculture Research.Your article cannot be published until you have signed the appropriate license agreement. Within the next few days you will receive an email from Wiley?s Author Services system which will ask you to log in and will present you with the appropriate licence for completion.OnlineOpen is available to authors of articles who wish to make their article open access. With OnlineOpen the author, their funding agency, or institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in PubMed Central and PMC mirror sites. In addition to publication online via Wiley Online Library, authors of OnlineOpen articles are permitted to post the final, published PDF of their article on a website, institutional repository, or other free public server, immediately on publication.If you want your article to be open access please choose the appropriate licence agreement when you log in to Wiley?s Author Services system. Click on ?Make my article OnlineOpen? and choose the appropriate license by clicking on ?Sign license agreement now? when you log in to Wiley?s Author Services system.If your manuscript includes colour figures you will need to provide a Colour Work Agreement form. Please send all hardcopies of this form to the address below:Customer Services (OPI)John Wiley & Sons Ltd, European Distribution CentreNew Era EstateOldlands WayBognor RegisWest SussexPO22 9NQ","palabras_clave":"BIOFILM|ARTIFICIAL SUBSTRATE|RECYCLABLE MATERIALS|WATER QUALITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":530,"idioma_id":4,"titulo":"Rickettsia infection in Amblyomma tonelliae, a tick species from the Amblyomma cajennense complex","resumen":"The present study was performed to evaluate the Rickettsia infection in Amblyomma tonelliae ticks from Argentina. All ticks were subjected to DNA extraction and tested by a battery of PCRs to amplify fragments of four rickettsial genes, 23S-5S, gltA, ompA and htrA. Two ticks were positive. The Rickettsia detected in one tick represents a new lineage which is named Rickettsia sp. strain El Tunal. This new strain belongs to the canadensis group because it is closely related to Rickettsia monteiroi, Rickettsia canadensis and Candidatus ?Rickettsia tarasevichiae?. They clustered together on a high supported clade with both gltA and htrA genes. The other positive tick was infected with Candidatus ?Rickettsia amblyommii?. The results presented in this study constitute the first records of Rickettsia infection in A. tonelliae ticks. However, the medical relevance of these findings should be considered cautiously because the pathogenicity of Rickettsia sp. strain El Tunal and Candidatus ?R. amblyommii? remains undetermined.","palabras_clave":"RICKETTSIA|AMBLYOMMA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":531,"idioma_id":4,"titulo":"The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis","resumen":"The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1\/2 (ERK1\/2) as part of the mechanism that regulates StAR retention on the OMM and activity.","palabras_clave":"CHOLESTEROL TRANSPORT|MITOCHONDRIAL DYNAMICS|STAR PHOSPHORYLATION|MAP KINASES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":532,"idioma_id":4,"titulo":"Engineered chimeras reveal the structural basis of hexacoordination in globins: A case study of neuroglobin and myoglobin","resumen":"Abstract  BACKGROUND:  Myoglobin (Mb) and neuroglobin (Ngb) are representative members of pentacoordinated and bis-histidyl, hexacoordinated globins. In spite of their low sequence identity, they show surprisingly similar three-dimensional folds. The ability of Ngb to form a hexacoordinated bis-histidyl complex with the distal HisE7 has a strong impact on ligand affinity. The factors governing such different behaviors have not been completely understood yet, even though they are extremely relevant to establish structure-function relationships within the globin superfamily.  METHODS:  In this work we generated chimeric proteins by swapping a previously identified regulatory segment - the CD region - and evaluated comparatively the structural and functional properties of the resulting proteins by molecular dynamics simulations, and spectroscopic and kinetic investigations.  RESULTS:  Our results show that chimeric proteins display heme coordination properties displaced towards those expected for the corresponding CD region. In particular, in the absence of exogenous ligands, chimeric Mb is found as a partially hexacoordinated bis-histidyl species, whereas chimeric Ngb shows a lower equilibrium constant for forming a hexacoordinated bis-histidyl species.  CONCLUSIONS:  While these results confirm the regulatory role of the CD region for bis-histidyl hexacoordination, they also suggest that additional sources contribute to fine tune the equilibrium. General significance Globins constitute a ubiquitous group of heme proteins widely found in all kingdoms of life. These findings raise challenging questions regarding the structure-function relationships in these proteins, as bis-histidyl hexacoordination emerges as a novel regulatory mechanism of the physiological function of globins.","palabras_clave":"myoglobin|hexacoordination|neuroglobin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":533,"idioma_id":4,"titulo":"Karyotypes and DNA content in Bignoniaceae","resumen":"Cytogenetic studies in 22 Bignoniaceae species were performed. Most taxa are from Argentina, one from Brazil, and  two are cultivated (from South Africa and USA). All data are new, including first counts for Bignonia binata, Handroanthus  ochraceus, Tabebuia aurea and the genus Podranea. Most taxa are diploid (2n = 40): members of tribes Bignonieae  (Adenocalymma, Amphilophium, Bignonia, Cuspidaria, Dolichandra, Fridericia, and Tynanthus), Catalpeae (Catalpa)  and the Tabebuia alliance (Handroanthus and Tabebuia). Dolichandra unguis-cati and Handroanthus chrysotrichus were  polyploid (2n = 80). Tribes Jacarandeae (Jacaranda) and Tecomeae (Tecoma) were unusual (with 2n = 36), whereas  Podranea ricasoliana (Tecomeae) had 2n = 38. The basic number x = 20 is proposed as the base number for the family.  Chromosomes are small. The average length was 1.21 &#956;m. Average haploid karyotype length was 28.13 &#956;m, ranging  from 18.63 in Dolichandra cynanchoides to 37.63 in D. unguis-cati. Type m chromosomes were the most common. One  to five sm pairs were found in 16 species and one st pair in Cuspidaria convoluta and Podranea ricasoliana. One to  15 four microsatellites, in long or short arms, were detected in nine species. Karyotypes are symmetrical. Asymmetry  indices ranges were: A1 = 0.11-0.23, A2 = 0.14-0.22. The karyotypes of P. ricasoliana and C. convoluta were the most  asymmetrical. Most species were karyologically indistinguishable based on conventional staining, but some could be distinguished  by a combination of traits. 1C nuclear DNA content for 12 species were within the range 0.64-2.02 pg. In  Bignoniaceae there is a common karyotypical pattern of mostly small m chromosomes with few cryptic chromosomal rearrangements.","palabras_clave":"Bignonaceae|Karyotypes|chromosome numbers|DNA content"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":535,"idioma_id":4,"titulo":"Glutamate Release Machinery Is Altered in the Frontal Cortex of Rats with Experimental Autoimmune Encephalomyelitis","resumen":"Experimental autoimmune encephalomyelitis (EAE) is an animal model that mimics many of the clinical and pathological features of the human disease multiple sclerosis (MS). Both are inflammatory demyelinating and neurodegenerative pathologies of the central nervous system associated with motor, sensory, and cognitive deficits. In MS, gray matter atrophy is related to the emergence of cognitive deficits and contributes to clinical progression. In particular, prefrontal cortex injury and dysfunction have been correlated to the development of fatigue, one of the most common and disabling symptoms in MS. However, the molecular bases of these changes remain unknown. Taking advantage of EAE similitude, we herein analyze functional and morphological changes in isolated cortical presynaptic terminals (synaptosomes) from an acute rat model. We found impaired glutamate release in the frontal cortex from EAE rats. This defect appeared along with the onset of the disease, reversing when clinical signs were no more evident. Biochemical analysis of EAE synaptosomes revealed alterations in the presynaptic release machinery and in the response to depolarization, which was accompanied by abnormal synapsin I phosphorylation and dispersion. These changes were associated with reduced synaptic vesicle mobility, with no alterations in synaptosomal morphology as evidenced by electron microscopy. The present are the first pieces of evidence unraveling the molecular mechanisms of frontal cortex neuronal dysfunction in EAE and, possibly, MS.Experimental autoimmune encephalomyelitis (EAE) is an animal model that mimics many of the clinical and pathological features of the human disease multiple sclerosis (MS). Both are inflammatory demyelinating and neurodegenerative pathologies of the central nervous system associated with motor, sensory, and cognitive deficits. In MS, gray matter atrophy is related to the emergence of cognitive deficits and contributes to clinical progression. In particular, prefrontal cortex injury and dysfunction have been correlated to the development of fatigue, one of the most common and disabling symptoms in MS. However, the molecular bases of these changes remain unknown. Taking advantage of EAE similitude, we herein analyze functional and morphological changes in isolated cortical presynaptic terminals (synaptosomes) from an acute rat model. We found impaired glutamate release in the frontal cortex from EAE rats. This defect appeared along with the onset of the disease, reversing when clinical signs were no more evident. Biochemical analysis of EAE synaptosomes revealed alterations in the presynaptic release machinery and in the response to depolarization, which was accompanied by abnormal synapsin I phosphorylation and dispersion. These changes were associated with reduced synaptic vesicle mobility, with no alterations in synaptosomal morphology as evidenced by electron microscopy. The present are the first pieces of evidence unraveling the molecular mechanisms of frontal cortex neuronal dysfunction in EAE and, possibly, MS.","palabras_clave":"synaptic transmission|glutamate release|autoimmunity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":536,"idioma_id":4,"titulo":"A Preventive Cytokine Treatment of the Viral Infectious Bursal Disease (IBD) of Chickens","resumen":"A Preventive Cytokine Treatment of the Viral Infectious Bursal Disease (IBD) of ChickensRosana Mattiello1, Elisa D?Ambrosio1, Maximiliano Wilda2, Melisa Sayé3, Mariana R. Miranda3,Pablo Maure4, Claudio A. Pereira3 and Fabio A. Digirolamo3, 51 Faculty of Veterinary Sciences, University of Buenos Aires, Argentina2 Institute of Science and Technology Dr. César Milstein (ICT Milstein), CONICET, Buenos Aires, Argentina3 Medical Research Institute A. Lanari (IDIM), CONICET and University of Buenos Aires, Buenos Aires, Argentina4 Centre of Veterinary Immunotherapy (CIV), Buenos Aires, Argentina5 Faculty of Agricultural Sciences, Catholic University of Argentina (UCA), Buenos Aires, ArgentinaInfectious bursal disease (IBD) is a viral disease of young chickens that produce severe lesions in the bursa of Fabricius and other organs inducing immunosuppression and mortality in birds. This study indicates that oral administration of IFN-&#945; and IL-2 during 16 days produced a significant reduction in animals? morbidity and mortality to IBD virus (IBDV) infection accompanied with a decrease in symptoms and bursal tissue damage. The treatment also increased body weight, not only in birds challenged with IBDV, but also in uninfected controls. Infected birds treated with cytokines presented the same bursal index and organs? weight that controls; since untreated animals showed a significant decrease in these parameters. Finally, cytokine administration represents a new alternative to IBDV vaccination.Key words: cytokines, infectious bursal disease, poultryJ. Poult. Sci., 52: 145-150","palabras_clave":"cytokines|infectious bursal disease|poultry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":542,"idioma_id":4,"titulo":"Precipitation event distribution in central argentina: Spatial and temporal patterns","resumen":"The annual amount of precipitation inputs received by a site during a full year is considered a dominant spatial and temporal control of primary productivity and other related process in arid to subhumid ecosystems. However, to be effectively used by plants, these inputs have to escape runoff, favoured by large and less frequent precipitation events, and evaporation losses, favoured by small and more frequent events. Thus, available water for plant transpiration is not only influenced by the annual sum of precipitation events but also by their frequency-size distribution. In this paper, we characterize this distribution and its association to total annual precipitation inputs through space (five sites along a tenfold precipitation gradient across 1000km) and time (1961-2010) in the plains of central Argentina. We decomposed total precipitation into two structural components, which are the frequency and mean size of events, showing that they have similar contributions (log-log slopes&#8776;0·5) explaining precipitation shifts in space. Over time, however, we found a preponderance of mean event size explaining precipitation fluctuations, particularly towards wetter sites (log-log slopes increasing from 0·61 to 0·88). The relative variability of event sizes, independent of their mean size (i.e. inequality), was numerically characterized with Gini coefficients derived from Lorenz curves, which showed highly constant values in space and time. Assuming fixed event-size thresholds for evaporation and runoff, and ignoring other controls beyond precipitation structure, the proportion of water potentially available for plant transpiration grew with total precipitation, raising from 0·45 to 0·71 from the driest to the wettest sites, but displaying stronger responses to total precipitation in time, particularly in drier sites. No long-term trends in any of the precipitation structure variables were detected. Response functions of frequency and mean size of events to annual precipitation together with Lorenz curves appeared to be robust descriptors of precipitation regimes that, not requiring any a priori assumptions, are useful to assess how spatial and temporal shifts in total precipitation may concurrently affect its relative availability for plant transpiration.","palabras_clave":"Lorenz curves|Precipitaton structure|Rainfall gradients|Water balance|Climate change"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":544,"idioma_id":4,"titulo":"Nutritive and Xenobiotic Compounds in the Alien Algae Undaria pinnatifida From Argentine Patagonia","resumen":"Seaweeds have been used since ancient times as food. The edible brown algae Undaria pinnatifida is native to  northeast Asia; however, in 1992 the first specimens in Patagonian environments were found and since then,  rapidly expanded. The main object of this study was to determine, for the first time in Argentina, nutritive  composition and concentrations of trace elements and hydrocarbons in these alien algae and evaluate their  usefulness as food. Sexually mature U. pinnatifida samples were collected at 10m depth in Nuevo and San José  gulfs. The first site is influenced by activities from Puerto Madryn city, and the later place was considered as  control. Protein, dietary fiber and mineral concentrations were similar in both gulfs and in the same order as in  eastern countries. The highest crude protein, indigestible fiber, calcium and magnesium concentrations were  found in blades, lipid concentration was highest in sporophyll and sodium and potassium in midrib. Amino acids  showed the highest concentrations in blades and these were higher than those reported in kelp from Japan.  Cadmium, arsenic, mercury and hydrocarbons were detected but only cadmium showed concentrations that  could be a risk for consumption. In Argentina, maximum acceptable levels of these contaminants in seaweeds  are not established.","palabras_clave":"Undaria|Heavy metals|Trace elements|Nutritive composition"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":545,"idioma_id":4,"titulo":"Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation","resumen":"DNA is continuously exposed to damaging  agents that can lead to changes in the genetic information  with adverse consequences. Nonetheless, eukaryotic cells  have mechanisms such as the DNA damage response  (DDR) to prevent genomic instability. The DNA of  eukaryotic cells is packaged into nucleosomes, which fold  the genome into highly condensed chromatin, but relatively  little is known about the role of chromatin accessibility in  DNA repair. p19INK4d, a cyclin-dependent kinase inhibitor,  plays an important role in cell cycle regulation and  cellular DDR. Extensive data indicate that p19INK4d is a  critical factor in the maintenance of genomic integrity and  cell survival. p19INK4d is upregulated by various genotoxics,  improving the repair efficiency for a variety of DNA  lesions. The evidence of p19INK4d translocation into the  nucleus and its low sequence specificity in its interaction  with DNA prompted us to hypothesize that p19INK4d  plays a role at an early stage of cellular DDR. In the present  study, we demonstrate that upon oxidative DNA damage,  p19INK4d strongly binds to and relaxes chromatin. Furthermore,  in vitro accessibility assays show that DNA is  more accessible to a restriction enzyme when a chromatinized  plasmid is incubated in the presence of a protein  extract with high levels of p19INK4d. Nuclear protein  extracts from cells overexpressing p19INK4d are better  able to repair a chromatinized and damaged plasmid. These  observations support the notion that p19INK4d would act  as a chromatin accessibility factor that allows the access of  the repair machinery to the DNA damage site.","palabras_clave":"DNA DAMAGE RESPONSE|INK4 PROTEINS|GENOME INTEGRITY|CHROMATIN RELAXATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":546,"idioma_id":4,"titulo":"Selective Hydrogenation by Novel Composite Supported Pd Egg - Shell Catalysts","resumen":"Two organic?inorganic mixed phase supports were prepared, comprising an alumina filler and polymers of different chemical nature. Four low loaded Pd catalysts were prepared. Good activities and selectivities were obtained during the hydrogenations of styrene, 1-heptyne and 2,3-butanedione. The catalysts were found to have excellent mechanical properties and could be used in applications needing high attrition resistance and crushing strength. In this sense, processes for fine chemicals using slurry reactors or processes for commodities using long packed beds could advantageously use them","palabras_clave":"Pd\/COMPOSITE|EGG-SHELL CATALYSTS|SELECTIVE HYDROGENATION|MECHANICAL PROPERTY IMPROVEMENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":547,"idioma_id":4,"titulo":"Promoting Effect of Tin in Platinum Electrocatalysts for Direct Methanol Fuel Cells (DMFC)","resumen":"Pt-Sn anodic catalysts supported on multiwall carbon nanotubes, mesoporous carbon and Vulcan carbon were prepared using a deposition-reduction technique with sodium borohydride, characterized by different techniques and tested as anodes in a single direct methanol fuel cell at low temperatures. Characterization and CO stripping results indicate the presence of promoting effects of Sn over Pt in catalysts supported on Vulcan carbon and carbon nanotubes. This would mainly be caused both by geometric modifications induced by Sn placed in the surroundings of the active metal phase and probable electronic effects. These promoting effects make the oxidation of CO to CO2 at low potentials easier, thus improving the CO tolerance of the anodic electrocatalyst. On the other hand, Pt-Sn catalysts supported on mesoporous carbon do not show a proper metallic phase needed for a good electrochemical behavior. When catalysts were tested in a DMFC, Pt-Sn catalysts supported on Vulcan carbon and carbon nanotubes gave a better power density than a commercial one mainly when working at low current densities.","palabras_clave":"electrocatalizadores |celdas de combustibles|PtSn"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":548,"idioma_id":5,"titulo":"Acetilación sostenible de biopolímeros mediada por un alfa-hidroxiácido de origen natural","resumen":"La organocatálisis es una rama de la catálisis que utiliza moléculas orgánicas de bajo peso molecular como catalizadores, entre ellos, los ácidos alfa-hidroxicarboxílicos. En la presente contribución se demuestra la aplicabilidad de la ruta catalizada por un ácido alfa-hidroxicarboxílico de origen natural y de producción industrial nacional como es el ácido L-(+)-tartárico para la acetilación no convencional de dos biopolímeros: almidón y celulosa bacterial. Algunas ventajas inherentes a la metodología de acetilación propuesta son su sencillez, el uso de un catalizador orgánico no metálico de origen natural, no tóxico y biodegradable; y la operación con alta eficiencia en ausencia de solventes y bajo condiciones moderadas de reacción. En el caso del almidón, la manipulación de las condiciones de reacción permitió obtener almidones acetilados con valores de grado de sustitución (GS) en el rango de 0.06 a 2.93 en 3 horas de reacción, con aplicación potencial en la industria de alimentos, medicina y plásticos. En el caso de la celulosa bacterial (BC), la acetilación organocatalítica permitió alcanzar valores de GS en el rango de 0.35-0.60, de utilidad en la regulación de la polaridad de las nanofibras de celulosa para su potencial compatibilización con matrices\/medios no polares. Los productos de la acetilación fueron caracterizados en términos de estructura química y cristalinidad.","palabras_clave":"ORGANOCATÁLISIS|ACETILACIÓN|ALMIDÓN|CELULOSA BACTERIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":549,"idioma_id":4,"titulo":"Endophytic colonisation of tobacco, corn, wheat and soybeans by the fungal entomopathogen Beauveria bassiana (Ascomycota, Hypocreales)","resumen":"Beauveria bassiana (Balsamo) Vuillemin (Ascomycota: Hypocreales) is a cosmopolitan fungal entomopathogen that can live as an endophyte in plants, without causing any symptoms (Van Bael et al., 2005). According to Rodriguez, White, Arnold, and Redman (2009), it is classified as Clavicipitaceous, class 1, Type III in its role as an &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; endophyte. Landa et al. (2013) observed hyphae of B. bassiana in leaf and stem &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; intercellular spaces, and in determined zones of the parenchyma tissue of the main &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; leaf vain, but not in the vascular tissues. However, Quesada-Moraga, Landa, &nbsp; Muñoz-Ledesma, Jiménez-Díaz, and Santiago-álvarez (2006), previously, reported &nbsp;&nbsp; &nbsp; fungal growth into the xylem vessels observed by scanning electron microscopy. In &nbsp;&nbsp;&nbsp;&nbsp; &nbsp; some cases, colonisation of plant tissues by B. bassiana has been demonstrated to &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; provide protection against insects and to inhibit insect development and establish-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ment (Cherry, Banito, Djegui, &amp; Lomer, 2004; Ownley, Pereira, Klingeman, &nbsp; &nbsp; Quigley, &amp; Leckie, 2004; Vega et al., 2008). The aim of the present work was to &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; evaluate the most appropriate method to inoculate B. bassiana as an endophytic &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; fungus and to assess its stability over time in tobacco, corn, wheat and soybeans. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; B. bassiana (LPSC 1067) from the culture collection of the Spegazzini Institute, &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; La Plata, Argentina was chosen based on its laboratory efficacy against Argentinian &nbsp;&nbsp;&nbsp; &nbsp; pest insects (Pelizza, Elíades, Saparrat, et al., 2012; Pelizza, Eliades, Scorsetti, &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ","palabras_clave":"BEAUVERIA BASSIANA|ENDOPHITE|ZEA MAYS|GLICINE MAX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":550,"idioma_id":5,"titulo":"Tracción de losa en el margen boreal del océano Paleotetis y deformación en el interior de Gondwana (incluyendo el cordón plegado de Ventana)","resumen":"Durante el Paleozoico tardío tuvieron lugar varios procesostectónicos en el interior de Pangea que generaron estructuras re­conocidas endiferentes lugares de nuestro planeta. Con el objetivo de relacionar estosprocesos con factores geodinámicos, se realizaron reconstruccionespaleogeográficas absolutas de Gondwana utilizando datos paleomagnéticos parados lapsos: 1) Pensilvaniano (Carbonífero tardío)-Guadalupiano (Pérmico medio)y 2) Lopingiano (Pérmico tardío)-Triásico medio. Para lograr un mejor ajuste delos polos paleomagnéticos de Gondwana se consideraron distintos dominioslitosféricos separados por fajas deformadas localizadas a lo largo de arcos decircunferencia. A través de las reconstrucciones se obtuvieron vectores dedesplazamiento que indicarían un movimiento SO-NE de diferentes dominios deGondwana. Desde el punto de vista geo­dinámico, durante el Paleozoico tardío,el manto terrestre habría presentado una gran zona de sumidero en el hemisferioen el que se habría ensamblado Pangea a través de la unión de Gondwana conLaurasia. Así se habría cerrado el océano Reico y ha­bría permanecido activauna zona de subducción en el margen boreal del océano Paleotetis. La tracciónde losa en este margen habría generado diferentes procesos tectónicos. EnGondwana Occidental, la tracción de losa mencionada, habría provoca­dorotaciones antihorarias diferenciales de distintos dominios litosféricos através de megazonas de fallas transcurrentes. Es­te proceso habría inducidoflujos toroidales en el manto, cuyos vórtices se habrían ubicado en los centrosde los arcos a lo largo de los cuales se habrían canalizado los desplazamientoslaterales entre los dominios. Estos movimientos, junto con un rápidodesplazamiento sur-norte de Pangea, habrían tenido vital importancia en ladeformación de distintas localidades para las que se han sugerido direccionesde esfuerzos SO-NE coherentes con las orientaciones de los vectores dedesplazamiento calcula­dos. Entre estas localidades se encontraría el CordónPlegado de Ventana.","palabras_clave":"Gondwana|Geodinamia|Deformación intra-placa|Flujo toroidal"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":552,"idioma_id":4,"titulo":"Ultrastructure of the stigma and style of Cabomba caroliniana Gray (Cabombaceae)","resumen":"Cabomba Aubl. is a genus that presents a range offeatures that have made it to be considered a potential geneticmodel for studies of early angiosperm evolution. Therefore,any study that expands our knowledge of this genus is potentiallyuseful for the understanding of the evolution of earlyangiosperms. This paper reports the study of the anatomyand the ultrastructure of the stigma and the style ofCabomba caroliniana Gray during the 2 days of anthesisusing bright-field microscope, fluorescence microscope andtransmission electron microscope. The stigma is dry and haspluricellular papillae. The style is hollow with a central canalcoated by an epithelium. The papillae have fewer organellesthan those typical of glandular cells, and they are covered by acuticle that is broken when pollen germinates. The ultrastructureof epithelial cells indicates that the cells lining the canalare secretory. The canal is filled with a fibrillar and granularsubstance. The pollen tubes grow inside the canal through thissubstance. The results are discussed in the context of what isknown for other species of angiosperms.","palabras_clave":"Cabomba |Stigma|Style|Ultrastructure"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":554,"idioma_id":4,"titulo":"Combined chemical oxidation and biological processes for herbicide degradation","resumen":"BACKGROUNDFenton and photo-Fenton processes were explored as photochemical pre-treatments to improve the biodegradability of wastewater containing atrazine, a commercial pesticide. The effects of H2O2, Fe3+ and irradiation level on the degradation processes were studied and the optimal conditions determined.RESULTSFenton and photo-Fenton oxidation systems were able to remove 85 and 100% of atrazine, respectively, in a 120&#8201;min period. These processes produced a biocompatible solution, removing 100% of the initial biorecalcitrant compound; however, cyanuric acid remained in the effluent after the chemical oxidation treatment due to the stability of the N-heterocyclic ring of this acid. Nevertheless, it was found that the cyanuric acid remaining from the photo-oxidative process can be removed by means of an anaerobic treatment.CONCLUSIONSThe results obtained in this work indicate that a coupled photo-Fenton?biological treatment system is a feasible method to achieve the complete mineralization of biorecalcitrant pollutants such as atrazine.","palabras_clave":"advanced oxidation processes|photo-Fenton|biological treatment|combined process"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":555,"idioma_id":4,"titulo":"The human occupation of northwestern Patagonia (Argentina): Paleoecological and chronological trends","resumen":"In this paper we compile and analyze an exhaustive database of paleoecological information and 14C dates from archaeological sites in northwestern Patagonia (Argentina, South America) in order to assess the macro-regional distribution of human populations since the Late Pleistocene, and its relation with the evolution of Patagonian climate and landscapes. We explore the spatial and temporal distribution of evidence during this period and discuss potential sampling biases affecting the record in different ecological conditions. The analysis is set in the frame of three main ecological regions that have implications for human subsistence: Andean forest, grass steppe, and shrub steppe. The intensity of the archaeological signal differs among these regions through time, being stronger and more homogeneous in the grass steppe. In the Andean forest and the shrub steppe the signal is weaker and absent during some short periods of the Middle Holocene. We identify likely sampling biases producing these tendencies, since these three regions present variable research cover and intensity. On the other hand, we also suggest that these differences may reflect variations in the intensity of human occupation of the different regions. This macro-regional synthesis of the paleoecology and archaeology  of northwestern Patagonia provides a platform for developing future oriented research at smaller analytical scales.","palabras_clave":"PALAEOECOLOGY|ARCHAEOLOGY|RADIOCARBON CHRONOLOGY|HUMAN PALAEODEMOGRAPHY|SOUTH AMERICA|NORTHERN PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":556,"idioma_id":4,"titulo":"SPARC (Secreted Protein Acidic and Rich in Cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage","resumen":"Secreted protein, acidic and rich in cysteine (SPARC) is involved in many biological process including liver fibrogenesis, but its role in acute liver damage is unknown. To examine the role of SPARC in acute liver injury, we used SPARC knock-out (SPARC&#8722;\/&#8722;) mice. Two models of acute liver damage were used: concanavalin A (Con A) and the agonistic anti-CD95 antibody Jo2. SPARC expression levels were analyzed in liver samples from patients with acute-on-chronic alcoholic hepatitis (AH). SPARC expression is increased on acute-on-chronic AH patients. Knockdown of SPARC decreased hepatic damage in the two models of liver injury. SPARC&#8722;\/&#8722; mice showed a marked reduction in Con A-induced necroinflammation. Infiltration by CD4+ T cells, expression of tumor necrosis factor-&#945; and interleukin-6 and apoptosis were attenuated in SPARC&#8722;\/&#8722; mice. Sinusoidal endothelial cell monolayer was preserved and was less activated in Con A-treated SPARC&#8722;\/&#8722; mice. SPARC knockdown reduced Con A-induced autophagy of cultured human microvascular endothelial cells (HMEC-1). Hepatic transcriptome analysis revealed several gene networks that may have a role in the attenuated liver damaged found in Con A-treated SPARC&#8722;\/&#8722; mice. SPARC has a significant role in the development of Con A-induced severe liver injury. These results suggest that SPARC could represent a therapeutic target in acute liver injury.","palabras_clave":"SPARC|ACUTE LIVER INJURY|ENDOTHELIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":558,"idioma_id":4,"titulo":"Evaluation of high-resolution satellite precipitation estimates over southern South America using a dense rain gauge network","resumen":"Six different satellite rainfall estimates are evaluated for a 24-hour accumulation period at 12 UTC with a  0.25 degree resolution. The rain gauge data are obtained froma dense inter-institutional station network for December  1, 2008 to November 30, 2010 over South America. The evaluated satellite rainfall products are the Tropical  Rainfall Measuring Mission 3B42 V6, V7 and RT, the NOAA\/Climate Prediction Center Morphing technique  (CMORPH), Hydroestimator (HYDRO) and the Combined Scheme algorithm (CoSch). The validation and intercomparison  of these products are focused on southern South America. The performance improves in the ?blended?  estimates by including microwave observations and surface observations in the adjustments, i.e., 3B42 V6, V7  and CoSch; however, large overestimations are detectable inCMORPH, principally for extreme values over plains  areas. The estimates based on parameters associated with infrared images only (HYDRO) underestimate precipitation  south of 20° S and tend to overestimate the warm precipitation to the north. The inclusion of observed  precipitation data is convenient from monthly (3B42 V7 and V6) to daily scales (CoSch) and improves the estimates.  The estimates that include microwave observations show a strong tendency to overestimate extreme  values of precipitation over 70mm. This effect is strongly evident in northern and central Argentina and southern  Brazil. A deeper assessment is necessary, particularly over the Central Andes, where effects of topography principally  associated with solid precipitation correspond to the persistence of majorly overestimated precipitation.","palabras_clave":"estimaciones de preciitacion|precipitacion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":559,"idioma_id":5,"titulo":"Inhibición de butirilcolinesterasa en dos perros intoxicados  y confirmación analítica de carbofuran como agente causal","resumen":"Resumen Ferré, D.M.; Saldeña, E.L.; Albarracín, L.; Neuilly, V.; Gorla, N.B.: Inhibición de bu- tirilcolinesterasa en dos perros intoxicados y confirmación analítica de carbofuran como agente causal. Rev. vet. 26: 1, 43-48, 2015. La mortandad de animales domésticos y silves- tres debido a intoxicaciones por plaguicidas es internacionalmente elevada, en la mayoría de los casos por exposición a insecticidas. Los más comúnmente citados son los anticolines- terásicos organofosforados y carbamatos. Los perros y gatos mascotas son buenos recursos para alertar sobre el uso de venenos en el medio natural y los posibles riesgos para el hombre con el que comparten el ambiente. En dos perros con signos de intoxicación, el objetivo del presente trabajo fue efectuar estudios complementarios de laboratorio para identificar con certeza la causa de las intoxicaciones. Se reporta el manejo clínico, la aproximación diagnós- tica a través de la determinación en plasma de butirilcolinesterasa (BChE) por espectrofoto- metría y la confirmación del tóxico por cromatografía líquida de alta precisión masa- masa. La actividad BChE de cada perro fue de 227 UI\/L, lo que significa una inhibición de más del 90% de la actividad basal. La presencia de carbofuran en plasma y contenido gástrico corro- boró la causa de las intoxicaciones. Los plaguicidas agrícolas inhibidores de colinesterasa, especialmente los carbamatos, son la principal causa de envenenamiento en animales. Por tal motivo se sugiere como herramienta de diagnóstico la medición de BChE en animales intoxi- cados, así como bregar por mayores controles en la comercialización de plaguicidas ricos en ingredientes activos con bajas DL50, como el caso del carbofuran. En salud pública debería exigirse la denuncia obligatoria y registro centralizado de las intoxicaciones intencionales o accidentales por plaguicidas agrícolas en animales, cuyo mal uso puede atentar incluso contra la vida de seres humanos. Palabras clave: perro, intoxicación, carbofuran, colinesterasa, HPLC.","palabras_clave":"PERRO|INTOXICACION|CARBOFURAN|COLINESTERASA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":561,"idioma_id":4,"titulo":"B-Chronic Lymphocytic Leukemia Autophagyc Cell Death by the Use of Manganese Doped Zinc Oxide Nanoparticles and Photo-Dynamic Therapy","resumen":"B-Chronic Lymphocytic Leukemia (B-CLL) usually follows an adverse, relentless clinical course by slowly developing drug resistance to fludarabine and other chemotherapeutic agents, as well as by acquiring new different genetic abnormalities. As B-CLL cells spontaneously produce high amounts of Reactive Oxygen Species (ROS) having an altered redox state in relation to that of normal B lymphocytes, we decided to probe different metal Zinc nanoparticles (ZnNPs) and quantify the levels of Singlet Oxigen (SO) to see if variations of its intracellular concentrations could execute and accelerate deadly programs in leukemic cells rather than in normal B lymphocytes, when applied with Photodynamic Therapy (PDT). In this way, we developed and tested a variety of metal ZnNPs of which one made of 0.5% Manganese Doped Zinc Oxide (ZnO:Mn) was finally selected for further testing as it had the best fludarabine resistant B-CLL cells in vitro killing activity, specially when combined with PDT. An interesting and rapidly dying process of B-CLL cells, known as autophagy, was always seen under Transmission Electronic Microscopy (TEM) when incubated with these 0.5% Mn doped ZnO NPs. This phenomenon correlated well with those intracellular increases of SO when PDT was administered, and measured by a novel method first described by us. As this therapy seems to be very specific to fludarabine resistant B-CLL cells, producing almost no damage to normal lymphocytes, it could surely contribute in the near future as a new innovative targeted strategy to be delivered in the clinical setting for the definitive benefit of these bad prognostic patients.","palabras_clave":"Leukemia|Nanoparticles|Photodynamic Therapy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":562,"idioma_id":4,"titulo":"Photocatalytic inactivation of bacterial spores using TiO2 films with silver deposits","resumen":"The presentwork evaluates the enhancement of the photocatalytic inactivation of bacterialspores employing TiO2 films with silver deposits compared to TiO2 films withoutmetal deposition. Bacillus subtilis spores spread over TiO2 films withdifferent silver contents were irradiated with artificial UV-A light. Theperformances of the coatings were evaluated by the quantum efficiencyparameter, which relates the inactivation rate with the radiation absorption rateby the coating. Spectral diffuse transmittance and reflectance measurements ofthe films were carried out to evaluate the fraction of energy absorbed by thecoatings. TiO2 and Ag\/TiO2 films characterization also included X-rayDiffraction (XRD), Atomic Force Microscopy (AFM), X-ray photoelectronspectroscopy (XPS), and Scanning Electron Microscopy (SEM). A notable increasein the photocatalytic inactivation was observed by increasing the silvercontent of the coatings, reaching a maximum quantum efficiency with the samplecontaining 1.09 wt.% Ag\/TiO2. The addition of higher amounts of silver renderedlower inactivation, thus indicating the existence of an optimum Ag\/TiO2relation.","palabras_clave":"TITANIUM DIOXIDE|SILVER|BACILLUS SUBTILIS SPORES|INACTIVATION|QUANTUM EFFICIENCY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":564,"idioma_id":5,"titulo":"Estudio de poblaciones de linfocitos B en pacientes VIH ? seropositivos","resumen":"Introducción: La infección por VIH está asociada con anormalidades en las poblaciones linfocitarias, incluidos los linfocitos B. Estas perturbaciones llevan a un incremento de co-infecciones específicas y a una pobre respuesta a vacunas. La caracterización de los linfocitos B en pacientes infectados es importante para entender el impacto de la viremia en la respuesta inmune.  Objetivos: Caracterizar las subpoblaciones de linfocitos B en pacientes con serología positiva para VIH y correlacionar estos hallazgos con los patrones de electroforesis de proteínas encontrados.  Material y métodos: Se incluyeron 30 pacientes VIH ? positivos adultos en diferentes estadios de progreso de la enfermedad bajo tratamiento antriretroviral. Las subpoblaciones de linfoctios B fueron inmunotipificadas por citometría de flujo como: CD24alto CD38alto  (B transicionales),  CD27- (B vírgenes), CD27+ IgD+ (B memoria sin cambio de isotipo), CD27+ IgD- (B memoria con cambio de isotipo) y CD27+ (B memoria totales). Se realizaron proteinogramas por electroforesis en analizador semiautomático y se categorizaron las patrones encontrados como normal, hipogammaglobulinemia, hipergammaglobulinemia policlonal, bandas oligoclonales o banda monoclonal.  Resultados: Demostramos un desbalance del compartimiento de linfocitos B caracterizado principalmente por un incremento de células B transicionales y una disminución de linfocitos B de memoria sin cambio de isotipo. Encontramos correlación entre el recuento de linfocitos T CD4+ y el recuento de células B de memoria totales.   Discusión: Este estudio demuestra el desbalance del compartimiento de linfocitos B en pacientes adultos infectados por el virus VIH aún en pacientes bajo tratamiento antiretroviral. Esto tiene importantes implicancias para la susceptibilidad a co-infecciones extracelulares.","palabras_clave":"VIH|linfopenia|linfocitos B"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":566,"idioma_id":4,"titulo":"A new Early Cretaceous brachiosaurid (Dinosauria, Neosauropoda) from northwestern Gondwana (Villa de Leiva, Colombia)","resumen":"Brachiosaurid sauropods achieved a broad distribution during the Late Jurassic, which has been considered toprovide evidence of their origins during the Middle Jurassic, prior to the breakup of Pangea. In contrast to their broad  geographic distribution during the Late Jurassic, formally named brachiosaurid species from the Cretaceous have so far been restricted to the Aptian?Albian of North America, which has been interpreted as a signal of differential extinction and\/or a bias in the Early Cretaceous fossil record. Here we describe a new brachiosaurid titanosauriform taxon from the Early Cretaceous of Colombia, which is represented by axial elements. The material was recovered from marine sediments of the Paja Formation (Barremian), close to the locality of Villa de Leiva. The weakly laterally expanded and divided transverse processes of the anterior-most caudal vertebrae allows the recognition of a new sauropod taxon, Padillasaurus leivaensis, gen. et sp. nov. In order to test the phylogenetic relationships of the new taxon, we performed a cladistic analysis that recovered Padillasaurus as a brachiosaurid titanosauriform. This position is supported by a combination of characters, including the presence of blind fossae in anterior caudal vertebrae. Among titanosauriforms, the presence of blind fossae in anterior caudal vertebrae is an apomorphic character that is exclusive to Giraffatitan, Venenosaurus, Cedarosaurus, and Abydosaurus. Although more complete remains are needed to test more thoroughly the affinities of the new taxon, the available evidenceindicates that brachiosaurids survived at lower latitudes in Gondwana until at least the Early Cretaceous.","palabras_clave":"Sauropodomorpha|Biogeografía|Evolución|Dinosauria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":567,"idioma_id":4,"titulo":"Pseudomonas fluorescens Pf-5 genome-wide mutant screen for resistance to the antimicrobial peptide alfalfa snakin-1","resumen":"Snakin-1, a peptide produced by higher plants, has broad-spectrum antibiotic activity, inhibiting organisms ranging from Bacteria to Eukaryotes. However, the mode of action against target organisms is poorly understood. As a first step to elucidate the mechanism, we screened a mutation library of Pseudomonas fluorescens Pf-5 in LB and agar medium supplemented with alfalfa snakin-1 (MsSN1). We identified three biofilm formation-related Pseudomonas mutants that showed increased resistance to MsSN1. Genetic, physiological and bioinformatics analysis validated the results of the mutant screens, indicating that bacterial adhesion protein lapA is probably the target of MsSN1. Collectively, these findings suggest that snakin-1 acts on microbial adhesion properties.","palabras_clave":"ACTION MECHANISM|ANTIMICROBIAL ACTIVITY|ANTIMICROBIAL PEPTIDE|SNAKIN 1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":568,"idioma_id":4,"titulo":"IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness","resumen":"IL-27, a member of the IL-12 family of cytokines, is produced by APC, displays pro- and anti-inflammatory effects but its effects on human NK cells remain ill-defined. Therefore, in this work we investigated the effect of IL-27 on human NK cells. We observed that mature dendritic cells (mDC) secreted IL-27 and that blockade of IL-27R (CD130) reduced the amount of IFN-&#947; produced by NK cells during their co-culture, highlighting a role of IL-27 during DC?NK cell crosstalk. Accordingly, human rIL-27 stimulated IFN-&#947; secretion by NK cells in a STAT1-dependent manner, induced up-regulation of CD25 and CD69 on NK cells, and displayed a synergistic effect with IL-18. Pre-incubation experiments demonstrated that IL-27 primed NK cells for IL-18-induced IFN-&#947; secretion which was associated with an IL-27-driven up-regulation of T-bet expression. Also, IL-27 triggered NKp46-dependent NK cell-mediated cytotoxicity against Raji, T-47D and HCT116 cells, and IL-18 enhanced this cytotoxic response. Such NK cell-mediated cytotoxicity involved up-regulation of perforin (pfp), granule exocytosis and TRAIL-mediated cytotoxicity but not Fas-FasL interaction. Moreover, IL-27 also potentiated Ab-dependent NK cell-mediated cytotoxicity (ADCC) against mAb-coated target cells. We conclude that IL-27 stimulates NK cell effector functions, which might be relevant in different physiological and pathological situations.","palabras_clave":"CYTOTOXICITY|IFN-GAMMA|IL-18|IL-27|NK CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":569,"idioma_id":4,"titulo":"Benthic-pelagic uncoupling between the Northern Patagonian Frontal System and Patagonian scallop beds","resumen":"Availability of planktonic food in the bottom is the most important factor to explain the persistence and recurrent localization of Patagonian scallop (Zygochlamys patagonica) populations. The establishment of the scallop Sea Bay bed (SBB) has been related with food supply from the Northern Patagonian Frontal System (NPFS). In this article outputs from high resolution numerical models combined with particle tracking methods were used to identify for the first time potential physical mechanisms of food transfer. The model results showed no evidence of benthic-pelagic coupling between the NPFS and the SBB. Theyalso revealed that the dominant instantaneous semidiurnal tidal currents and the mean N-NE flow on the inner-middle Patagonian shelf are the main dynamical mechanisms preventing particles released at the surface of the NPFS to reach the SBB area. Sensitivity studies changing the stochastic numerical method for solving the particle trajectories, the release month and location of the particles, the magnitude of the horizontal turbulent diffusion coefficient and the frequency of the wind forcing did not alter this conclusion significantly.","palabras_clave":"Northern Patagonian Frontal System|scallop beds|stochastic processes|benthic-pelagic coupling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":570,"idioma_id":4,"titulo":"Photocatalytic Inactivation of Escherichia Coli Aqueous Suspensions in a Fixed-Bed Reactor","resumen":"A fixed-bed, annular photoreactor is studied for the photocatalytic disinfection of Escherichia coli aqueous suspensions. Experiments were carried out under UV radiation employing P25 titanium dioxide immobilized onto glass Raschig rings. The photoreactor performance has been simulated following a predicted procedure that takes into account explicitly the radiation absorption step and a series-event disinfection mechanism. The modelling of the radiation field was carried out by Monte Carlo simulation. The reactor model has been compared with experimental data, being able to reproduce the evolution of the concentration of viable bacteria under different bacteria initial concentrations and irradiation levels.","palabras_clave":"FIXED-BED REACTOR|DISINFECTION|TITANIUM DIOXIDE|MONTE CARLO METHOD|RADIATION ABSORPTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":572,"idioma_id":4,"titulo":"Soaking and extrusion effects on physicochemical parameters, phytic acid, nutrient content and mineral bio-accessibility of whole rice grain","resumen":"A combination of soaking and extrusion processes of whole rice grain was studied. The effects of temperature (35?55 C) and time (24?48 h) of soaking treatment on phytic acid (PA), protein and ashes losses using a factorial design were evaluated. Taking into account ash, protein and PA losses, whole rice was soaked 24 h at 45 C and extruded using a Brabender single screw extruder. Effects of extrusion temperature (160?190 C) and moisture content (14?19 g\/100 g) on product characteristics were evaluated using surface response methodology. Values corresponding to the different responses were: Expansion (1.64?3.28), Specific Volume (5.68?11.06 cm3\/g), Water absorption (3.41?4.43 mL\/g) and Solubility (45.44?66.20 g\/100 g). The content of PA was reduced from 740.09 to 163.47 mg\/100 g (77%) after both processes, resulting in a higher mineral bio-accessibility, and a 7.3% decrease of protein digestibility. Total soluble phenolics and trolox equivalent antioxidant capacity (TEAC) were affected according to the treatment. Both treatments were important to obtain a nutritionally improved whole grain product.","palabras_clave":"BIO-ACCESSIBILITY|EXTRUSION|PHYTIC ACID|ROUGH RICE|SOAKING|WHOLE GRAIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":573,"idioma_id":4,"titulo":"Fruits from Ripening Impaired, Chlorophyll Degradation and Jasmonate Insensitive Tomato Mutants have Altered Tocopherol Content and Composition","resumen":"Since isoprenoids are precursors in the chlorophyll, carotenoid and tocopherol pathways, the study of  their metabolism is of fundamental importance in understanding the regulatory crosstalk that  contributes to the nutritional quality of tomato fruits. By means of an integrated analysis of  metabolite and gene expression profiles, we dissected isoprenoid metabolism in ripening-impaired  (ripening inhibitor and non-ripening), senescence-related (lutescent1 and green flesh) and jasmonate  insensitive (jasmonic acid insensitive 1-1) tomato mutants, all in the Micro-Tom genetic background.  It was found that the more upstream the location of the mutated gene, the more extensive the effect  on the transcriptional profiles of the isoprenoid-related genes. Although there was a distinct effect of  the analyzed mutations on chlorophyll, carotenoid and tocopherol metabolism, a metabolic  adjustment was apparent such the antioxidant capacity mostly remained constant. Transcriptional  profiles from the fruits of ripening and senescence-related tomato mutants suggested that  maintenance of the de novo phytyl diphosphate synthesis might, in later ripening stages, compensate  for the lack of chlorophyll-derived phytol used in tocopherol production. Interestingly, an  impairment in jasmonate perception led to higher total tocopherol levels in ripe fruits, accompanied  by an increase in antioxidant capacity, highlighting the contribution of tocopherols to this  nutritionally important trait.","palabras_clave":"Tomato mutants|Antioxidant capacity|Solanum lycopersicum|Atocopherol|Carotenoids|Chlorophyll|Jasmonic acid|Ripening"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":574,"idioma_id":4,"titulo":"Neotectonic reactivation of the western section of the Malargüe fold and thrust belt (Tromen volcanic plateau, Southern Central Andes)","resumen":"notectónica del sector oriental de la faja de chos malal","palabras_clave":"TROMEN PLATEAU|NEOTECTONICS|MALARGÜE FOLD AND THRUST BELT|CENTRAL ANDES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":575,"idioma_id":4,"titulo":"A conductivity study of preferential solvation of lithium ion in acetonitrile-dimethyl sulfoxide mixtures","resumen":"The electrical mobility of LiPF6 in acetonitrile?dimethyl sulfoxide (ACN?DMSO) mixtures, a potentialelectrolyte in oxygen cathodes of lithium-air batteries, has been studied using a very precise conductancetechnique, which allowed the determination of the infinite dilution molar conductivity and associationconstant of the salt in the whole composition range. In the search for preferential Li+ ion solvation, wealso measured the electrical conductivity of tetrabutylammonium hexafluorophosphate (TBAPF6), a saltformed by a bulky cation, over the same composition range. The results show a qualitative change in thecurvature of the LiPF6 molar conductivity composition dependence for ACN molar fraction (xACN)  0.95,which was not observed for TBAPF6. The dependence of the measured Li\/Li+ couple potential with solventcomposition also showed a pronounced change around the same composition. We suggest that theseobservations can be explained by Li+ ion preferential solvation by DMSO in ACN?DMSO mixtures withvery low molar fractions of DMSO.","palabras_clave":"electrical conductivity |solvation|redox potential|ACN-DMSO mixtures|lithium"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":579,"idioma_id":4,"titulo":"Cross-reactivity between the  soybean protein P34 and bovine caseins'","resumen":"Purpose: Soy-based formulas are widely used as dairy substitute to treat milk allergic patients. However, reactions to soy have been reported in a small proportion of patients with IgE-mediated allergy to milk. The aim of this work was to analyze if P34 a mayor soybean allergen might be involved in this cross-reactivity. Methods: In vitro recognition of P34 was evaluated by immunoblotting, competitive ELISA and BAT using sera from allergic patients. In vivo cross-reactivity was studied using an  IgE-mediated milk allergy mouse model. Results: P34 was recognized by IgE antibodies from sera of milk allergic patients, casein specific monoclonal antibodies and sera from milk allergic mice. Spleen cells from sensitized mice incubated with milk, soy or P34 secreted IL-5 and IL-13, while IFN-&#947; remained unchanged. In addition, the cutaneous test was positive with cow?s milk proteins (CMP) and P34 in the milk allergy mouse model. Moreover, milk-sensitized mice developed immediate  symptoms following sublingual exposure to P34. Conclusions: The results  presented herein demonstrate that P34 shares epitopes with bovine casein, which are responsible for inducing hypersensitivity symptoms in milk allergic mice. This is the first report that demonstrates the in vivo cross-allergenicity of P34, which could set a new avenue for the development of a mucosal vaccine.","palabras_clave":"FOOD ALLERGY|SOYBEANS|MILK|P34 PROTEIN|CROSS-REACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":580,"idioma_id":4,"titulo":"Time evolution of Pb(II) speciation in Pampa soil fractions","resumen":"Soil pollution by  heavy metals, particularly lead is an important environmental concern; the  bioavailability of such pollutants is strongly dependent on its chemical form.  Here, the speciation of  Pb(II) in soil fractions as a function of time shortly after its incorporation  is studied, using a selective sequential extraction method. The sample came  from an Argentinean Pampas region, and was extensively characterized, including  Rietveld analysis of the silt+clay fraction XRD pattern to find the major  mineral components. A shelter experiment was run twice, once in winter, once in  summer. The results show different speciation time profiles in both cases,  showing faster changes in winter due to higher water content. The summer  experiment corresponds to an earlier stage in the speciation profile evolution  compared with winter. The soluble\/exchangeable fraction decreases with time in  summer but shows a lower and constant value in the winter run. A high  proportion is found to be adsorbed onto the stable (aluminosilicates+quartz)  mineral fraction. The results strongly  suggest that, even at a short time after soil pollution with Pb, a high  proportion is adsorbed onto the mineral fraction, with only a low fraction  being bioavailable;. The most stable (mineral incorporated) form is observed to  increase with time. Soil water content appears to be more important than  temperature in determining the differences between the two ","palabras_clave":"Sequential selective extraction|availability |retention|heavy metal"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":583,"idioma_id":4,"titulo":"Geoid Model and Altitude at Mount Aconcagua Region (Argentina) from Airborne Gravitty Survey?.","resumen":"Geoid Model and Altitude at Mount Aconcagua Region (Argentina) from Airborne Gravitty Survey?.","palabras_clave":"Geoid|Aconcagua|Airborne gravity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":584,"idioma_id":5,"titulo":"Determinación de  registros semióticos en una investigación didáctica: un caso aplicado a números complejos","resumen":"En el presente trabajo se describe el proceso de determinación de losregistros semióticos pertinentes para una investigación didáctica. Lamisma se refiere a conversiones de representaciones semióticas desubconjuntos de números complejos. Se exponen y ejemplifican lasargumentaciones que, siguiendo los lineamientos teóricos de Duval y lasobservaciones planteadas por D?Amore, marcaron las etapas delproceso. Se detallan los criterios y preguntas que orientaron la seleccióny delimitación de los registros, esperando que contribuyan como insumopara investigaciones que utilicen registros semióticos como herramientateórico-metodológica.Palabras clave: registros semióticos pertinentes, criterios dedelimitación, números complejos","palabras_clave":"registros semióticos|criterios de delimitación|números complejos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":585,"idioma_id":5,"titulo":"Quebrada del río Miriguaca (Antofagasta de la Sierra, Puna meridional argentina): nuevos resultados de recientes prospecciones","resumen":"La quebrada del río Miriguaca, en la microrregión de Antofagasta de la Sierra, ha sido objeto desde el año 2006 de investigaciones arqueológicas intensivas destinadas a contribuir al conocimiento de las estrategias de uso del espacio y manejo de recursos de los grupos que la habitaron entre ca. 5000-700 años AP.  Como resultado de las primeras prospecciones se identificaron 11 sitios prehispánicos, asociados a un amplio lapso temporal (ca. 3600-700 años AP), en su mayoría emplazados en el curso medio del río Miriguaca y sólo dos en el tramo oriental del curso inferior.  Desde entonces, se llevan adelante actividades de excavación y análisis de los materiales registrados en varios de ellos.Posteriores prospecciones realizadas en febrero de 2012, permitieron registrar nuevos sitios en el tramo occidental del curso inferior del río Miriguaca, incluyendo su confluencia con el río Punilla. En este trabajo se presentan y caracterizan las evidencias recuperadas, las que aportaron a la comprensión de la dinámica ocupacional de la quebrada al ampliar el rango temporal de ocupación del curso inferior. Este no sólo fue habitado en momentos formativos, como se proponía en aportes precedentes, sino también luego de ca. 1000 años AP. Por otro lado, los resultados alcanzados posibilitaron contribuir a la discusión de modelos de ocupación del espacio y organización social y política propuestos para momentos formativos y tardíos en la microrregión.","palabras_clave":"DINAMICA DE OCUPACION|NUEVA EVIDENCIA|QUEBRADA DE MIRIGUACA|PUNA MERIDIONAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":586,"idioma_id":5,"titulo":"La construcción de las desigualdades urbanas. Interacciones, negociaciones y conflictos","resumen":"Este trabajo es un resumen de lo que se viene trabajando desde el UBACyT que dirige Mariano Perelman. El texto constituye un avance de investigación.'La construcción de las desigualdades urbanas. Interacciones, negociaciones y conflictos' PROYECTO UBACYT  20020120300003,  CONVOCATORIA: UBACYT  2013-2015.El proyecto se enmarca en los debates sobre la producción de las desigualdades urbanas y, especialmente,el acceso de ciertos grupos sociales (considerados por algunos como pobres, como excluidos o bien comomarginados, entre otras figuras posibles) a la ciudad. En ese marco, se recupera una perspectiva centradaen los contactos entre diferentes actores y grupos sociales en el espacio público. Se entiende que estos contactosse configuran como instancias en las cuales se reproducen los mecanismos sociales que dan lugar a las desigualdadesy se producen otros nuevos. A fin de dar cuenta de cómo opera la producción de las desigualdades, la investigaciónse focaliza en aquellos contactos, encuentros o desencuentros que tienen lugar en relación al accesoa la ciudad, los usos del espacio urbano y el habitar. Nuestras investigaciones buscan comprender cómo experimentanlas personas dichas desigualdades y, finalmente, cuáles son y cómo operan los mecanismos a través de loscuales se construyen las diferencias sociales a escala barrial abarcando no solamente la dimensión económicasino también las relaciones de poder que se manifiestan en la producción de las diferencias sociales mencionadas.En el marco del análisis de las interacciones, los encuentros y los desencuentros, los conflictos fueron ocupandoun lugar cada vez más importante a la hora de comprender la producción de sentidos ya que en estas instanciasse cristalizan los diferentes usos del espacio y los modos con los cuales los actores involucrados piensan,actúan y argumentan en torno a la ciudad.","palabras_clave":"CONFLICTO URBANO|DESIGUALDADES SOCIALES ENCONTRADAS|ESPACIO PÚBLICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":589,"idioma_id":5,"titulo":"Colección, agencia y sociabilidad. Obras de producción  espontánea en espacios funcionales de El Fogón de los Arrieros","resumen":"El objetivo de este texto es analizar un conjunto de ?experiencias en obras? que se encuentran sobre columnas, puertas y una ventana de El Fogón de los Arrieros (Resistencia, Chaco, Argentina). Obras que integran una colección compleja por integrar pintura, escultura, murales, pero también objetos ?banales? exhibidos en medio de obras de artistas de reconocimiento nacional e internacional.    En este contexto, las obras por analizar interesan no sólo por sus caracteres formales, objetuales y funcionales, sino también por su traslocación, des-funcionalización, desaparición de las superficies de inscripción en las que se encuentran, considerandolas ?aparatizaciones? de su espacio arquitectónico. Las obras son analizadas por ello, como  índices de vitalidad que nos permiten recuperar relacionalmente el modo de vida fogonero, una visible sociabilidad local &#61485;manifiesta también en redes de artistas, intelectuales y gestores&#61485;, atendiendo a las diferentes modalidades de agencia que asumen los artistas, el ?dueño? de casa, y las obras mismas.","palabras_clave":"Fogón de los Arrieros|aparatización|agencia|sociabilidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":591,"idioma_id":4,"titulo":"Usage of spectral distortion for objective evaluation of personalized HRTF in the median plane","resumen":"Measuring the head-related transfer functions (HRTFs) for each subject is a complex process. Therefore, it is necessary to develop procedures that allow the estimation of personalized HRTFs. It is common to estimate the weights of the principal component analysis (PCA) of a group of subjects based on some anthropometric parameters using multivariable regression modelling. Moreover, to objectively evaluate the goodness of fit} between the original HRTFs and the personalized ones, the spectral distortion (SD) is usually used too. However, its suitability in the median plane, in which the spectral profiles are crucial to localize a sound source, has not yet been demonstrated. This paper analyses the validity of the SD as a measure of the quality of the HRTF personalization in the median plane, from the localization point of view. The HRTFs were modelled from the weights estimated by multiple linear regression and artificial neural networks (ANNs). The SD was used to compare the HRTFs measured with those estimated. Likewise, the level of fitting accuracy of characteristic resonance and notches in the median plane was also compared. Despite the fact that the SD scores of ANNs are lower than those of the multiple linear regression and are similar to those reported by other studies, the errors obtained from analysing both central frequencies and levels for resonance and notches could be discriminated.","palabras_clave":"HEAD RELATED TRANSFER FUNCTION|HRTF PERSONALIZATION|PRINCIPAL COMPONENT ANALYSIS|MULTIPLE LINEAR REGRESSION|ARTIFICIAL NEURAL NETWORK"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":593,"idioma_id":4,"titulo":"How Do Demographic and Social Factors Influence Parent-Offspring Conflict? The Case of Wild Black and Gold Howler Monkeys (Alouatta Caraya)","resumen":"In this study, we examined the influence of demography and social context on mother-offspring conflict in wild black and gold howler monkeys (Alouatta caraya) inhabiting two nearby sites in northern Argentina, one comprising continuous forest and one fragmented forest. These sites differed in population density (3.25 vs. 1.04 individuals\/ha), degree of home range overlap between neighboring groups (70 vs. 31%), and rate of intergroup encounters (2 vs. 0.02-1 encounters\/day), though not in interbirth interval or rate of infant mortality. During a 27-month study (September 2008 through November 2010), we observed 37 mother-offspring dyads across the two sites. We found a very similar pattern of mother-offspring conflict in both populations; specifically, the sites did not differ in any of the variables used to characterize the mother-offspring relationship (the time spent in contact, the rate at which the mother makes and breaks contact, the rate at which the infant breaks contact, the rate of maternal rejection, and signs of infant distress) except one (the rate at which the infant makes contact). Although mother-offspring conflict is a dynamic process that varies over time, our results suggest that the different demographic and social contexts found at the two study sites did not have a marked effect on quantitative aspects of the mother-offspring relationship in these populations of black and gold howlers. Finally, this study suggests that the environmental variability (ecological, demographic, and social traits) leads to a set of strategies used both by infants and mothers with a main goal of conflict resolution, with mothers specifically aiming to cope with the tradeoff between current and future reproduction.","palabras_clave":"ALOUATTA|PARENT OFFSPRING CONFLICT|DEMOGRAPHY|VARIABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":595,"idioma_id":5,"titulo":"El uso de parámetros magnéticos en estudios paleolimnológicos en Antártida","resumen":"En esta contribución se describen las distintas técnicas y mediciones magnéticas utilizadas en Magnetismo Ambiental y Paleomagnetismo. Tales mediciones ofrecen útiles indicadores para realizar estudios relacionados con cambios climáticos y ambientales, así como herramientas de datación. Si bien es ampliamente conocida la utilidad de la susceptibilidad magnética, se discute el potencial y necesidad del uso de parámetros adicionales obtenidos a partir de mediciones de magnetizaciones remanentes (natural, anhistérica e isotérmica), histéresis magnética y estudios termomagnéticos.Se presentan resultados magnéticos obtenidos en sedimentos lacustres del Archipiélago James Ross (NE de la Península Antártica). Se complementa con estudios sedimentológicos, hidroquímicos, geoquímicos y de estadística multivariada, pero se pone énfasis en los parámetros magnéticos y su relación con los distintos procesos que ocurren en los sistemas lacustres antárticos. Se analiza además el uso de las paleointensidades relativas como herramienta de datación en lagunas antárticas.","palabras_clave":"LAGOS|PALEOMAGNETISMO|PENÍNSULA ANTÁRTICA|PROXIES MAGNÉTICOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":596,"idioma_id":5,"titulo":"El registro arqueológico en el sitio La Olla (San Rafael, Mendoza): Implicaciones para las ocupaciones humanas en el valle medio del río Atuel","resumen":"Se presenta el registro arqueológico recuperado en el sitio La Olla, elcual comprende materiales cerámicos,líticos, arqueobotánicos, zooarqueológicos y bioantropológicos. Dichositio se encuentra localizado en el valle del río Atuel (Mendoza, Argentina). El trabajo intenta ajustar elconocimiento de la dispersión agrícola prehispánica utilizando información en sectores no estudiado previamente. Se definendos pulsos discontinuos en el depósito de La Olla, el más antiguo en torno a 1900 años 14C AP y el otroentre 700 y 400 años 14C AP. El análisis confirma una estabilidad en la subsistencia y dieta humana basada en recursos debajo retorno energético compuesta entre otros por algarrobo y animales pequeñoscomo peces y dasipódidos. Por otra parte, se evidencian cambios en la organizacióntecnológica que son interpretados en términos de movilidad y rangos de acción.De este modo, el sitio La Olla muestra cómo se manifestarían ocupacionespenecontemporáneas y espacialmente cercanas a los Contextos Atuel I y Atuel II.","palabras_clave":"CENTRAL WESTERN ARGENTINA|LATE HOLOCENE|HUNTER-GATHERERS|FARMING DISPERSAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":597,"idioma_id":4,"titulo":"Glyphosate vulnerability explains changes in root-symbionts propagules  viability  in  pampean grasslands","resumen":"Research into the impact of agricultural practices on plant symbionts is essential for understanding the factors that modulate plant community productivity and diversity. Although glyphosate is used worldwide as an herbicide, its effects on root symbionts under natural conditions have not been sufficiently studied. We performed a field experiment to evaluate the influence of glyphosate, used for promoting winter forage production, on the viability of arbuscular mycorrhizal fungi (AMF) and rhizobium propagules and other ecosystem traits in native grasslands. The number of viable propagules was strongly reduced with a single application at the recommended dose. Spore viability reduction was dependent on AMF species. Furthermore, changes in plant community composition and soil salinity were detected, which may eventually influence these symbionts in the future. Considering the low nutrient availability and high root-symbiont dependency of several species with forage value, repeated applications might lead to a loss in the grassland diversity and productivity, decreasing livestock production. Application of sublethal doses of this herbicide could avoid these damages, although success in increasing winter forage production would be less. Our results are relevant for understanding the effects of glyphosate on non-target species and designing sustainable land management systems.","palabras_clave":"SPORES|RHIZOBIUM PROPAGULES|NON TARGET ORGANISMS|GLYPHOSATE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":598,"idioma_id":4,"titulo":"Chemical catalyzed recycling of polymers: Catalytic conversion of PE, PP and PS into fuels and chemicals over H-Y","resumen":"In the following study the termocatalytic degradation of polyethylene of high and low density, (HDPE, LDPE), polypropylene (PP) and polyestyrene (PS) on the H-Y zeolite was performed. The catalytic activity was carried out in a batch reactor at 500 °C. The reaction time was 43,75 min. Liquid product yields ranged from ~42 and ~44% wt% for polyethylenes and PP, while the production of PS showed ~71 wt%. The gaseous products ranged between ~46 and ~52 for PE and PP and ~24 wt% for PS. The PP generated the greatest amount of carbonaceous residues (~10 wt%) whereas the LDPE produced the lowest (~4 wt%).","palabras_clave":"Termocatalytic degradation |Polyolefins|PS|H-Y zeolite"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":599,"idioma_id":4,"titulo":"Effect of temperature on biochemical composition, growth and reproduction of the ornamental red cherry shrimp.","resumen":"PONE-D-14-36102R1  Effect of temperature on biochemical composition, growth and reproduction of the ornamental red cherry shrimp Neocaridina heteropoda heteropoda (Decapoda, Caridea)  PLOS ONE    Dear Dr. López Greco,    Thank you for submitting your manuscript for review to PLOS ONE. After careful consideration, we feel that your manuscript will likely be suitable for publication if it is revised to addressed minor language issues. Therefore, my decision is 'Minor Revision.' There were many small language errors, and I think that my edits have improved the ms. I suggest that you read the edits carefully to make sure they are correct.     We invite you to submit a revised version of the manuscript that addresses the edits in the attached document file.     We encourage you to submit your revision within forty-five days of the date of this decision.     When your files are ready, please submit your revision by logging on to http:\/\/pone.edmgr.com\/ and following the Submissions Needing Revision link. Do not submit a revised manuscript as a new submission. Before uploading, you should proofread your manuscript very closely for mistakes and grammatical errors. Should your manuscript be accepted for publication, you may not have another chance to make corrections as we do not offer pre-publication proofs.    If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter.","palabras_clave":"BIOCHEMICAL COMPOSITION|GROWTH PERFORMANCE|NEOCARIDINA HETEROPODA HETEROPODA|REPRODUCTION|SHRIMP|TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":600,"idioma_id":5,"titulo":"Presencia de inclusiones piroclásticas en la cerámica de los siglos XV a XVII en el centro oeste y noroeste argentino","resumen":"En las últimas décadas, los análisis tecnológicos realizados sobre materiales cerámicos han revelado la importancia de las inclusiones de origen piroclástico en la composición de las pastas del Noroeste Argentino (NOA) y Centro Oeste Argentino (COA). Se trata de altos valores de inclusiones vitropumíceas (10%-30%), de formas subredondeada a angulares y gran homogeneidad en sus tamaños. La presencia de estas inclusiones se asociaría a una práctica de manufactura extendida durante el Período Incaico en las áreas más meridionales del Imperio. Desde el amplio Noroeste Argentino hasta la provincia de Mendoza se han identificado en la actualidad más de una veintena de sitios con esta característica correspondientes a cerámica inca así como a estilos locales contemporáneos.  En este trabajo se presentan los resultados de recientes investigaciones en este sentido, en sitios de las provincias de Tucumán y Mendoza. Se trabaja sobre la hipótesis de que estas pastas representan un cambio tecnológico significativo en cada área,  que fue incorporado a partir de la presencia incaica en estos territorios y su función estuvo relacionada a los símbolos de poder usados por las poblaciones locales en el contexto del nuevo orden social y político imperante.","palabras_clave":"NOROESTE ARGENTINO|CENTRO OESTE ARGENTINO|PERÍODO INCA|INCLUSIONES PIROCLÁSTICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":604,"idioma_id":4,"titulo":"Five new cases of 46 XX aromatase deficiency: clinical follow-up from birth to puberty, a novel mutation, and a founder effect.","resumen":"CONTEXT: Aromatase is the key enzyme for estrogen biosynthesis and is encoded by the CYP19A1 gene. Since 1991, several molecular CYP19A1 gene alterations associated with aromatase deficiency have been described in both sexes. OBJECTIVE: The objective of the study was to detect CYP19A1 mutations in five aromatase-deficient 46,XX patients, to describe the clinical follow-up from birth to puberty and to perform haplotype analysis associated with the high-frequency c.628G&gt;A splice mutation in Argentinean patients. DESIGN: The design of the study was the sequencing of the coding and flanking intronic regions of the CYP19A1 gene in all patients and parents. Haplotype analysis of patients carrying the c.628G&gt;A mutation was also performed. PATIENTS: Clinical and biochemical findings in five new cases and one previously reported female aromatase-deficient patient (46,XX) are described. All patients presented with ambiguous genitalia at birth. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency as well as other steroidogenic defects were ruled out. RESULTS: Phenotypic variability among the affected patients was found during follow-up. Direct sequencing of the CYP19A1 gene from genomic DNA revealed one novel mutation (c.574C&gt;T) in two patients. In silico analysis predicted the c.574C&gt;T mutation to be probably damaging. Four of six nonrelated patients presented with the c.628G&gt;A splice mutation. Haplotype analysis showed that the c.628G&gt;A splice mutation is associated with the same haplotype in our population. CONCLUSIONS: Increased knowledge on phenotypical variability found in female aromatase-deficient patients is useful to improve the detection rate in this disorder. In our population, a genetic founder defect has probably contributed to an increase in the incidence of the c.628G&gt;A splice mutation.","palabras_clave":"aromatase |aromatase deficiency|founder effect"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":605,"idioma_id":5,"titulo":"TAFONOMÍA DE VERTEBRADOS HOLOCÉNICOS DEL SITIO ARQUEOLÓGICO CUEVA SALAMANCA 1 EN LA PUNA SALADA ARGENTINA.","resumen":"Se presentan los resultados del análisis tafonómico de restos de vertebrados  procedentes del sitio arqueológico Cueva Salamanca 1 (CS1), situado en Antofagasta  de la Sierra, Catamarca, a 3665 msnm, dentro de la Puna Salada argentina. Este sitio  contiene ocupaciones de cazadores-recolectores con dataciones del Holoceno Medio.  Se trabajó con una muestra de especímenes identificables (n=277) y una de  especímenes no identificables (n=514) de los diferentes estratos del sitio. La  conservación de los materiales analizados es buena y no se observaron sesgos  tafonómicos significativos. En general, predominaron los procesos naturales intra-sitio,  como la acción de humedad, por sobre procesos atmosféricos como la meteorización,  aunque en ningún caso implicaron daños sustanciales. La alta frecuencia de trazas  antrópicas en relación con la baja incidencia de las de carnívoros sugiere que los  humanos fueron el principal agente de acumulación. . La información obtenida se  comparó con la de otros sitios arqueológicos, y con los datos paleoecológicos y  paleoambientales disponibles para la región.","palabras_clave":"tafonomía|Holoceno medio|Puna|vertebrados"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":607,"idioma_id":4,"titulo":"Seasonal patterns and responses to an extreme climate event of rotifers community in a shallow eutrophic Pampean lake","resumen":"Shallow lakes of temperate areas experience seasonal and inter-annual variability in weather conditions, impacting on their biological communities. Here, we studied the temporal fluctuation of the zooplankton community in a highly eutrophic shallow lake, Laguna Chascomu´s. Rotifers and the cyclopoid  copepod Acanthocyclops robustus dominated the community. The most important rotifers were Brachionus caudatus, B. havanaensis, and Keratella tropica. The abundance of the two Brachionus species reached maximum values in late summer\/early autumn. In contrast, K. tropica and A. robustus did not display seasonal patterns. A prolonged period of low water temperature resulted in a massive fish winterkill event (in 2007), which seemingly allowed the development of unusually dense populations of cladocerans. We used vector autoregressive models to analyze the rotifer time series. The model accounted for 76% of the variance in rotifer abundance and provided of their dependence on temperature and chlorophyll a. In addition, the impact of the fish winterkill on rotifer abundance could be assessed through intervention analysis. The evidence collected here suggests that the zooplankton community structure is controlled by fish planktivory, while rotifers population dynamics are mostly driven by temperature and available food. Both processes seem highly responsive to forcing weather variables","palabras_clave":"Zooplankton community|Rotifers|Seasonal dynamics|Fish winterkill"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":608,"idioma_id":4,"titulo":"Burrowing activity by armadillos in agroecosystems of central Argentina: Biogeography, land use, and rainfall effects","resumen":"Land use change and agricultural practices are among the main factors affecting biodiversity, and require understanding of how differing species responses shape wildlife communities in rural landscapes. During the last 2?3 decades, the Pampas of central Argentina have experienced an agricultural expansion along with rapid adoption of a non-tillage system. In some areas armadillos are increasingly considered agricultural pests, not only because they can damage and contaminate silo bags and may act as direct consumers of crops, but also their burrowing activities interfere with farming practices. Here, we describe variations in activity of armadillos in the Pampas of Buenos Aires province, central Argentina, and discuss how biogeography, land use, and rainfall may have affected these species in the rural landscape. We carried out four sampling sessions between December 2011 and June 2013 (including two periods of normal rainfall and two periods of high rainfall), surveying 392 plots (196 crop fields and 196 rangelands) at 25 different localities (covering the five different ecological units of the Pampas). In each plot, we surveyed for signs (burrows and holes) along a 600 m by 6 m transect, in order to assess armadillo activity. Chaetophractus villosus (large hairy armadillo) showed the highest activity, with 5968 signs at 79% of the plots surveyed; whereas, 1866 signs of Dasypus hybridus (southern long-nosed armadillo) were found in 36% of the plots. Generalized  linear mixed models revealed that C. villosus is more active mainly in the Inland Pampas and in cropland plots, whereas, D. hybridus is more active in the Flooding Pampas at plots with active livestock use. Both species showed less burrowing activity during the second year of surveys, in a period of exceptionally high rainfall. Our results suggest that the omnivorous C. villosus may have benefited from agriculturization and non-tillage, particularly in the Inland Pampas where sandy soils favor burrowing, whereas, the more myrmecophagous D. hybridus may be in retraction.","palabras_clave":"Dasypus |Chaetophractus|Cropland| Agriculture| Buenos Aires"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":609,"idioma_id":5,"titulo":"Emprendimiento de fabricacion de ladrillos con plastico reciclado involucrando actores publicos y privados","resumen":"Esta revista está indizada por Latindex. Resumen: El  artículo muestra la experiencia desarrollada en la ciudad de Bell Ville, Córdoba, por el Centro Experimental de la Vivienda Económica -CEVE-  que consistió en la transferencia de una tecnología para la producción de elementos constructivos utilizando plásticos reciclados.  El Estado provincial y local junto a organizaciones de la sociedad civil, empresas, instituciones académicas y CEVE aunaron sus esfuerzos en la ejecución de un trabajo cooperativo con el objetivo de aportar soluciones para la recuperación y tratamiento de residuos plásticos urbanos, promover la concientización ecológica de la población, implementar la separación en origen, la recolección diferenciada y el tratamiento y reutilización de estos residuos.","palabras_clave":"VIVIENDA|ECOLOGÍA|CONSTRUCCIÓN|PLÁSTICOS RECICLADOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":610,"idioma_id":5,"titulo":"Primer registro de Cryptocaryoxylon Leisman, una Lauraceae de la Formación El Palmar (Pleistoceno tardío), Entre Ríos, Argentina","resumen":"Este trabajo describe el primer registro de Cryptocaryoxylon Leisman del Pleistoceno tardío de Argentina. El ejemplar fue hallado en el Paraje Salto Grande (Cuenca del Río Uruguay, Entre Ríos, Argentina) en sedimentos fluviales de la Formación El Palmar. Los caracteres diagnósticos del material fósil son: Porosidad difusa a semicircular; vasos pequeños a medianos y numerosos, solitarios y múltiples radiales cortos; tilosis abundante; punteaduras radio-vasculares simples; parénquima axial vasicéntrico, aliforme y confluente; radios heterocelulares, uniseriados, biseriados raros, altos; fibras no septadas con paredes gruesas y presencia de numerosas células oleíferas en los extremos de radios. Las características anatómicas sugieren una relación con Cryptocarya (Lauraceae). Las características eco-anatómica son consistentes con un clima templado-cálido y húmedo durante este intervalo de tiempo.","palabras_clave":"Cryptocaryoxylon sp nov|Lauraceae|Pleistoceno tardío|Entre Ríos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":611,"idioma_id":5,"titulo":"Espacio de reflexión: el por qué y para quien de la investigación bioantropológica","resumen":"El propósito del presente trabajo es aportar a la reflexión, desde la experiencia adquirida en el campo de la antropología forense, como miembros de un equipo con pertenencia institucional en el sistema formal de ciencia y técnica, con historia aplicada a casos concretos de demanda comunitaria. A modo de ejemplo de estas actuaciones se expondrán dos experiencias vinculadas al Gran Chaco. La primera la constituye la solicitud realizada al equipo de antropología forense del Museo de La Plata por la comunidad wichi ?Pajarito? (Afwenchelhos), a través del Centro del Hombre Antiguo Chaqueño (Las Lomitas, Formosa), para la excavación de inhumaciones de sus ancestros en el Paraje Esteros (Provincia de Formosa). El fin último de dicha solicitud era legalizar y reivindicar sus derechos legítimos sobre las tierras, lo cual fue logrado a partir del informe final producido por nuestro grupo de trabajo. En segundo lugar presentaremos los resultados de la respuesta a requerimiento de comunidades aborígenes ante un hecho fortuito de hallazgo de restos óseos humanos en la localidad de ?El Quebracho?, Departamento de Ramón Lista (Provincia de Formosa). En estos casos el concepto de restitución aplicado indiscriminadamente, deja de tener sentido, ya que todas nuestras acciones surgieron del acuerdo y del consenso de los actores involucrados.","palabras_clave":"ARQUEOLOGÍA PUBLICA |GRAN CHACO|COMUNIDAD WICHI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":613,"idioma_id":5,"titulo":"DATACIONES Y CIRCULACIÓN  HUMANA: INFLUENCIA DE LAS FLUCTUACIONES DEL SISTEMA  LACUSTRE PUEYRREDÓN POSADAS DURANTE EL HOLOCENO","resumen":"Este trabajo se centra en la discusión del proceso de poblamiento de la cuenca de los lagos Pueyrredón-Posadas-Salitroso (noroeste de Santa Cruz) sobre la base de la información obtenida en los últimos años y la presentación de nuevos fechados. Se relacionan las ocupaciones arqueológicas de la costa noreste del lago Pueyrredón con las dataciones vinculadas a la paleogeografía de la cuenca. Se analiza también la relevancia de los fechados presentados en una escala espacial más amplia, a nivel regional. Finalmente, se aborda la relación entre las variaciones de los niveles lacustres y la circulación humana teniendo en cuenta las evidencias recuperadas en los sitios emplazados en cotas superiores a los 300 mts, con cronologías correspondientes al Holoceno medio y tardío. Los resultados alcanzados confirman las expectativas planteadas por el modelo paleogeográfico; no obstante, los cambios observados en el paisaje a lo largo del Holoceno no parecen haber afectado la dinámica de la circulación humana.","palabras_clave":"cronología|niveles lacustres|circulación humana|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":615,"idioma_id":4,"titulo":"Patterns of daily and seasonal calling activity of a direct developing frog of the subtropical Andean forests of Argentina","resumen":"Climate often regulate different aspects of the life cycle and activity of amphibians. Climatic seasonality may impose severe restrictions on breeding patterns of direct developing terraranan frogs. We studied the influence of abiotic cues on calling activity of males of direct developing frog, Oreobates discoidalis in the Yungas forests of north-western Argentina. Vocalization activity and daily emission pattern of the vocal repertoire were registered with a frog-logger, and climatic variables were registered with a data logger. We sampled two reproductive seasons from 2010 to 2011. We employed ordinal logistic regression (OLR) to evaluate the relationship between independent climatic variables and the intensity of calling activity. The calling season of males of Oreobates discoidalis was triggered by the first rainfall of the aestival season. The species could be defined as crepuscular-nocturnal with a calling activity peak at dusk. Sporadic calling activity during day time was associated with conditions of high humidity and rainfall. Both, emission and intensity of the advertisement call activity were influenced by time of the day, high levels of relative air humidity, and presence of rainfall; air temperature was not a determinant factor in the calling activity of this frog species. Territorial calls were strongly associated to full chorus activity that could be associated to a mechanism of inter-male spacing.","palabras_clave":"FROG-LOGGER|ORDINAL LOGISTIC REGRESSION|TERRARANA|TERRITORIAL CALL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":616,"idioma_id":4,"titulo":"Down-regulation of catalase activity contributes to senescence induction in wheat leaves exposed to shading stress","resumen":"In shaded wheat (Triticum aestivum L.) leaves, the suppression of blue radiation (BR) triggers senescence. This phenomenon is correlated to an increase in oxidative stress symptoms and a decrease of catalase (CAT) activity, among other traits. Previous data suggest that the radiation signal transduction pathway may involve changes in Ca2+ and H2O2 homeostasis. For better a understanding of the interaction among the spectral composition of radiation, Ca2+ availability,and the antioxidant metabolism in the regulation of shade-induced senescence, detached wheat leaves were placed in a growth chamber and exposed to either blue (B, high BR transmittance) and\/or green (G, very low BR transmittance) Lee® filters in the absence or presence of 0.8 mM verapamil (a Ca2+ channels blocker), 4.0 mM EGTA (a Ca2+chelator), or 8.0 mM 3-amino-1,2,4-triazole (a CAT inhibitor). At defined time points, the leaf samples were analyzed for changesin chlorophyll content, specific activities of CAT, ascorbate peroxidase (APX), and guaiacol peroxidase (POX), CAT isozymes, and gene expression of CAT1, CAT2, and two senescence markers (TaSAG1 and TaSAG3). BR transmittance decreased the chlorophyll degradation rate and SAG genes expression either in leaves continuously exposed under the B filter, as well as in leaves previously exposed under the G filter. The effect of BR was associated with the maintenanceof a high CAT (but not APX and POX) activity, and it was suppressed either in the presence of3-AT or when Ca2+ availability was decreased. BR altered the CAT activity both at the transcriptional and at the posttranscriptional level. Nevertheless, different responses of CAT isozymes and CAT genes expression profiles to specific treatment combinations indicate that they differed in their regulatory pathways.","palabras_clave":"antioxidants|blue radiation|calcium|gene expression"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":617,"idioma_id":4,"titulo":"Micro-environmental conditions affect grass and shrub seedling emergence in denuded areas of the arid Patagonian Monte, Argentina","resumen":"Harsh micro-environments in bare soil patchesgenerated by disturbance may affect the emergence of plant species in desertecosystems. We evaluated the effects of litter addition on the emergence ofperennial grass and evergreen shrub species under different conditions of UVradiation and soil water content in disturbed patches of bare soil. We sowedseeds of perennial grasses (Nassella tenuis and Poa ligularis),and shrubs (Atriplex lampa, Larrea divaricata and Schinus johnstonii) in microcosms containing blocks of upper soil (28 cmdepth) subjected to different levels of three factors: litter (bare soilwithout litter cover, high quality litter cover from undisturbed plant patches,and low quality litter cover from disturbed plant patches), UV radiation (nearambient and attenuated UV radiation),and soil water (5-15 % and 15-25 % of volumetric soil water content). The patterns of seedling emergence in relation to litter, UV radiation,and soil water content varied among species independently of life form. Seedlingemergence of all species increased under exposure to UV radiation at allcombinations of litter and soil water factors. Highsoil water content had an important positive effect on the emergence of N. tenuis and L. divaricata in combination with UV radiation and litter. In contrast, soil water content didnot affect or affected negatively the emergence P. ligularis and A. lampain combination with litter and UV radiation.The emergence of S. johnstonii waspositively affected by soil water content under exposure to UV radiation,independently of litter. These results highlight the importanceof the combined effects of the presence and type of litter, soil water content,and UV radiation on seedling emergence of perennial grass and shrub species andconsequently on the vegetation reestablishment processes at disturbedareas.","palabras_clave":"ARID ENVIRONMENT|LITTER QUALITY|LITTER QUANTITY|SOIL WATER CONTENT|UV RADIATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":618,"idioma_id":4,"titulo":"Exposure to competitors influences parasitism decisions in ectoparasitoid fly larvae","resumen":"Much theoretical work has been done regarding patch exploitation in insects and several mechanisms have been proposed to describe and predict behaviours under different situations. However, almost no theoretical framework has been developed for parasitoids with host-seeking larvae, even though similar selection pressures are faced by the female of hymenopteran parasitoids and the larvae of dipteran parasitoids. Here we propose and show that factors such as pre-parasitism competition and host physiological state can modulate host orientation and acceptance behaviours in a dipteran parasitoid larva. When larvae were exposed to pre-parasitism competition and then offered different host odours and live hosts, they oriented towards and more readily accepted suboptimal hosts and were more prone to superparasitize. Our results show that the internal state modulates individual decisions that dipteran parasitoids make, confirming the presence of many previously neglected strategies in parasitoids with host-seeking larvae. Hence, comparative studies should be undertaken to form a complete picture of parasitism strategies.","palabras_clave":"ASILIDAE|HOST LOCATION|HOST ORIENTATION THRESHOLD|PRE-PARASITISM COMPETITION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":622,"idioma_id":4,"titulo":"Differential effects of environment-induced changes in body temperature on modafinil's actions against methamphetamine-induced striatal toxicity in mice","resumen":"Methamphetamine (METH) exposure can produce hyperthermia that might lead to toxicity and death. Modafinil is a wake-promoting compound that is also been prescribed off-label to treat METH dependence. Modafinil has shown neuroprotective properties against METH harmful effects in animal models. The goal of the present study was to test if the prevention of hyperthermia might play a role on the neuroprotective actions of modafinil against METH toxicity using various ambient temperatures. METH was administered to female C57BL\/6 mice in a binge regimen: 4 × 5 mg\/kg, 2 h apart; modafinil (90 mg\/kg) was injected twice, 1 h before first and fourth METH injections. Drugs were given at cold ambient temperature (14 °C) or hot ambient temperature (29 °C). Body temperature was measured during treatments. Brains were dissected out 6 days after treatments and processed for tyrosine hydroxylase (TH), dopamine transporter (DAT), GFAP and c-Fos immunohistochemistry. Exposure to hot ambient temperature exacerbated METH toxicity evidenced by striatal reductions in TH and DAT and increased GFAP immmunoreactivity. Modafinil counteracted reductions in TH and DAT, but failed to block astroglial activation. At both ambient temperatures tested modafinil did induce increments in GFAP, but the magnitude was significantly lower than the one induced by METH. Both drugs induced increases in c-Fos positive nuclei; modafinil did not block this effect. Our results suggest that protective effects of modafinil against METH-induced neurotoxicity may be dependent, in part, to its hypothermic effects. Nevertheless, modafinil maintained some protective properties on METH-induced alterations in the striatum at different ambient temperatures.","palabras_clave":"METHAMPHETAMINE|MODAFINIL|ASTROGLIA|STRIATUM|DOPAMINE|TOXICITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":623,"idioma_id":4,"titulo":"Acid Pretreatment of Two Phase Olive Mill Waste to Improve Bioavailable Sugars: Conditions Optimization Using Response Surface Methodology","resumen":"Two phase olive mill waste (TPOMW) is the semisolid waste generated for olive oil production. The organic fraction of this waste includes compounds that serve as a source of carbon and other nutrients for microorganisms, a feature that makes it potentially attractive for bioethanol production. To increase the bioavailability of cellulose and hemicellulose, no soluble carbohydrates, the application of pretreatments is required. This paper presents the results of the optimization of the sulfuric acid pretreatment variables of TPOMW applied to improve sugars bioavailability, using the response surface methodology. First, the Plackett?Burman method was applied to find the relevant variables of the process, using total sugars content as response variable. The results showed that temperature, acid concentration and solid:liquid ratio are significant for this process. Subsequently, these variables were optimized to maximize total sugars content, using the Box?Behnken method, an experimental array based on an incomplete three-level factorial design. The results indicate that the optimum working conditions were 10.10 % w\/w for H2SO4 concentration, 95.2 °C for temperature, and 0.17 g dry solid TPOMW per ml of acid solution, obtaining 67 % of sugars content increase.","palabras_clave":"RESIDUAL BIOMASS|ACID PRETREATMENT|SUGAR|OPTIMIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":624,"idioma_id":4,"titulo":"High hydrostatic pressure improves protein solubility and dispersion stability of mineral-added soy bean protein isolate","resumen":"The in&#64258;uence of ion type, ion concentration and pH on the effect of high hydrostatic pressure (HHP) on solubility and dispersion stability of soybean protein isolate (SPI) was analyzed. Solubilizing effect of HHP was detected for calcium-, magnesium- and iron- added SPI, the magnitude of this effect was dependent on ion type, ion concentration and pH. The solubilizing effect was highest for calcium, followed by magnesium and iron at pH 7.0. The pH value affected the levels of solubility and the range of calcium concentration where solubility was increased. HHP-denatured soybean proteins may coexist with different minerals and at different pHs in the form of soluble species. For a given calcium concentration, pH may affect the structure of HHP-induced aggregates, leading to different solubilities and dispersion stabilities. HHP improved the stability of insoluble proteins in calcium-added SPI dispersions, avoiding their settling. Our results con&#64257;rm that thermal treatment and HHP differentially affect protein-protein interactions. A transient dissociation of calcium from proteins during HHP is postulated. This dissociation would play a role in the structure of aggregates. When calcium is present during denaturation, different aggregates may be formed if calcium is bound to (thermal treatment) or transiently dissociated from (HHP) SPI proteins.","palabras_clave":"Soybean proteins isolate|High pressure|Calcium|Solubility"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":625,"idioma_id":4,"titulo":"Transesterification of sunflower oil with ethanol using sodium ethoxide as catalyst. Effect of the reaction conditions","resumen":"Typically, biodiesel is produced using vegetable oil and methanol as raw materials, and sodium methoxide as catalyst,  whereupon the obtained product is composed of methyl esters. However, the use of ethyl esters as biodiesel  presents many advantages compared to the methyl esters. In this work, the transesterification with ethanol to  produce ethyl esters using sodium ethoxide as catalyst was studied. The effect of temperature and alcohol and  catalyst concentration on the reaction conversion was investigated, in order to optimize these parameters  while also meeting the quality standards.  Itwas found that the optimal reaction conditions are: 1.6wt.% sodium ethoxide, 25 v\/v% ethanol and 55 °C,which  Allow obtaining a biodiesel composed 100% by ethyl esters that complies with the international quality standards.  On the other hand, it was observed that methanolysis reactions are faster than the ethanolysis and sodium  methoxide catalyst is more active than the corresponding ethoxide, due to the higher steric hindrance of the  ethoxi-radical and to the more intense saponification of sodium ethoxide in ethanol medium.","palabras_clave":"sodium ethoxide|biodiesel|ethanol|ethylester"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":626,"idioma_id":5,"titulo":"Carcinoma de células escamosas cutáneo en caninos","resumen":"Se realiza una revision sobre el carcinoma de células escamosos canini","palabras_clave":"Carcinoma|Perro"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":627,"idioma_id":5,"titulo":"Combinar trabajo y estudios superiores ¿Un 'privilegio' de jóvenes de sectores de altos ingresos??","resumen":"El presente artículo ahonda en la comprensión de una relación muy discutida desde las ciencias sociales: educación y trabajo. En particular partiremos de un dato interesante de la realidad argentina que contrasta con los antecedentes académicos sobre el tema: los jóvenes de sectores medios y altos que acceden a estudios superiores, son más proclives a articular trabajo y estudio que aquellos de sectores bajos. El estudio procesa, analiza y complementa datos longitudinales provenientes de estrategias de investigación cuantitativa y cualitativa a fin de dar cuenta de distintos factores que confluyen en esa realidad: desde datos estructurales y sociodemográficos, a percepciones y motivaciones subjetivas de los jóvenes en relación al trabajo y el estudio.","palabras_clave":"JOVENES|EDUCACION|TRABAJO|DESIGUALDAD SOCIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":629,"idioma_id":4,"titulo":"Chromosome fusion polymorphisms in the grasshopper, Dichroplus fuscus (Orthoptera: Acrididae: Melanoplinae): Insights on meiotic effects","resumen":"Robertsonian changes account for many of the changes in the evolution of the orthopteran karyotype; in their origin, a centric fusion is involved between two acro-telocentric chromosomes, forming a single bi-armed chromosome. It is usual for these rearrangements to be associated with profound changes in meiosis, such as modification in frequency and distribution of chiasmata. Dichroplus fuscus is a South American grasshopper with a wide distribution. In this work we analyzed nine populations from Misiones Province, north-eastern Argentina. This species presents a standard karyotype of 2n = 23\/24 (&#9794;\/&#9792;) with all chromosomes acro-telocentric and an X0\/XX chromosomal sex determining mechanism. This standard karyotype has been modified by the occurrence of two Robertsonian fusions involving chromosomes 1\/3 and 2\/4; values of fusions per individual (fpi) show a significant increase in the presence of karyotypic polymorphisms towards southern populations. In individuals showing chromosomal rearrangements, we observed a clear redistribution of chiasmata towards distal positions; significant differences were noted between Robertsonian homozygotes (Ho) and heterozygotes (Ht) for chromosomes arms L1 and M3, although this was not the case between Ho and Ht for chromosomes L2 and M4. With regard to the orientation of trivalents, values obtained for non-convergent orientation were low.","palabras_clave":"ORTHOPTERA|ACRIDIDAE|DICHROPLUS FUSCUS|ROBERTSONIAN FUSION|GRASSHOPPERS|CHIASMATA|TRIVALENTS|CHROMOSOMAL CLINE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":631,"idioma_id":5,"titulo":"Políticas universitarias y políticas científicas en Argentina pos 2000. Crisis, innovación y relevancia social","resumen":"Este artículo se centra en los últimos diez años deconstrucción de una política científica y tecnológica enel país, que tuvo su punto de inflexión en el año 2001,a partir de una crisis política, económica y social deenvergadura, y que se ha mantenido oscilando entre doscategorías centrales: innovación y relevancia. Para ello,se realiza una descripción somera de la situación inicial(crisis) y se analizan las diferentes políticas en ciencia ytecnología desarrolladas hasta hoy. El propósito centralconsiste en desentrañar las tensiones existentes entreuna orientación de política vinculada a la innovaciónproductiva y un renovado énfasis hacia la elaboraciónde prioridades y relevancia social. Esto lleva a discurrirsobre una recuperación de los postulados del pensamientolatinoamericano que ha surgido a mediados delsiglo &#57621;&#57621; en ciencia y tecnología","palabras_clave":"ciencia latinoamericana|continuidades y cambios|crisis económica|región sudamericana"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":632,"idioma_id":4,"titulo":"Drought Tolerance Screening Under Controlled Conditions Predicts Ranking of Water-Limited Yield of Field-Grown Soybean Genotypes","resumen":"Drought is a major limitation to crop yields worldwide. Screening for soybean yield under water deficit is often a bottleneck in breeding programmes. We assessed the validity of a standardized drought tolerance screening method to predict water-limited field performance of soybean in NW Argentina. First, to determine the phenological period when yield of glasshouse-grown plants was more sensitive to water deficit, we applied treatments during 21 days in V7, R3 or R5 stages, being the period from R5 to R6 the most critical for yield. Afterwards, two glasshouse experiments were carried out to quantify the tolerance of either eight or four genotypes, respectively, by applying a controlled water deficit of constant intensity during the critical period. Finally, yield data obtained in field trials in Argentina across several locations and seasons classified according to rainfall were analysed. Drought Susceptibility Index was calculated for each experiment and for field data, and rankings of tolerance were similar in all cases. This standardized method, which can be automated for high-throughput phenotyping, could represent a useful tool in breeding programmes for identifying soybean cultivars with improved performance under drought conditions.","palabras_clave":"DROUGHT STRESS|DROUGHT TOLERANCE|DROUGHT SUSCEPTIBILITY INDEX|PHENOTYPING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":633,"idioma_id":5,"titulo":"Murales efímeros para las Exposiciones Industriales durante el primer peronismo","resumen":"            Durante el primer peronismo (1946-1955),  se llevaron a cabo una serie de exposiciones de la industria con vistas a  promocionar la política del gobierno, no sólo en materia económica, sino  también social, política y cultural. Se realizaron en lugares claves del  espacio público: en la Avenida 9 de julio y en el predio de la Sociedad Rural. El  arquitecto encargado de construir las arquitecturas efímeras que contuvieron la  Exposición Industrial de 1945 y la Exposición de la Minería e Industrias  Afines, en 1946, por nombras sólo algunas, fue Jorge Sabaté. Estas particulares  arquitecturas, construidas especialmente para albergar las exposiciones,  estaban decoradas con murales. Debido a su carácter transitorio, se presenta  aquí una recomposición de su existencia a partir de bocetos y fotografías que  se conservan en archivos y bibliotecas.             El propósito de este texto es analizar  el programa visual presentado en las exposiciones de la industria que se  desarrollaron durante el primer peronismo. Examinaremos entonces cuál fue el  relato visual que se plasmó a partir de atender a quiénes pintaron murales y  qué características tuvo la imagen de industria que se evocó en los murales  para las exposiciones. &nbsp;  ","palabras_clave":"PERONISMO|EXPOSICIONES INDUSTRIALES|MURALES EFÍMEROS|POLÍTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":634,"idioma_id":5,"titulo":"Test de Raven: actualización de baremos en adolescentes argentinos y Efecto Flynn","resumen":"    Se presentan  los resultados obtenidos en la construcción de normas actualizadas del Test de  Matrices Progresivas de Raven, Escala General, para la ciudad de La Plata,  Argentina; y su comparación con las obtenidas en los años 1964 y 2000. Con ese  propósito se seleccionó una muestra de 1049 sujetos de ambos sexos, de 13 a 18  años de edad, alumnos de educación secundaria. El instrumento fue administrado colectivamente  y sin límite de tiempo. Los resultados se analizaron en tres grupos de edad y  se compararon con los baremos anteriores. Se observó que a mayor edad de los  sujetos, su rendimiento es mejor. La variabilidad de los puntajes es similar en  los grupos de edad. En relación con la tipificación del año 2000, en la que se  constató el efecto Flynn respecto de las normas de 1964, aparece un amesetamiento  y leve descenso de los puntajes directos necesarios para alcanzar el  rendimiento promedio. Asimismo se observaron diferencias en el orden de  dificultad entre las series de la prueba. El conjunto de estos resultados  confirman la necesidad de actualización de los baremos y de las características  del material de prueba, a los fines de una evaluación precisa.   ","palabras_clave":"EFECTO FLYNN|TEST DE RAVEN|BAREMOS|ADOLESCENTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":636,"idioma_id":5,"titulo":"Historia de la música en América Latina  Ese vasto territorio entre lo propio y lo ajeno","resumen":"La producción bibliográfica de la historia musical en América Latina ha generado desde diferentes perspectivas teóricas relatos que abarcan músicas, procesos y problemas heterogéneos. A menudo la clasificación territorial y cultural sobre lo latinoamericano, hispanoamericano,iberoamericano o indoamericano permite entrever parte de los sustentos teóricos que organizan los estudios historiográfico-musicales de la región. Esta propuesta pretende encontrar en el concepto de la transculturación uno de los lineamientos que permitan circunscribir criterios para el estudio histórico dela música de Latinoamérica.","palabras_clave":"MÚSICA|AMÉRICA LATINA|HISTORIOGRAFÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":637,"idioma_id":5,"titulo":"La economía moral del trabajo. La legitimidad social de las empresas recuperadas.","resumen":"La recuperación de empresas por sus trabajadores en la Argentina representa un proceso que a pesar de sus características disruptivas e innovadoras ha concitado una amplia legitimidad social. ¿Cuáles son las lógicas que fundan dicha legitimidad? ¿En qué medida esta valoración positiva se extiende a todos los atributos del proceso, aun los más disruptivos? ¿Cómo interactúan las lógicas operantes con los valores hegemónicos sobre los que se erige la sociedad capitalista? A través de la investigación por encuesta, realizamos una medición de la valoración social del proceso de recuperación de empresas en sus diferentes dimensiones e indagamos la configuración cultural que permite entender a la misma. Retomando los desarrollos teóricos en torno al concepto de economía moral, sostenemos que la legitimidad que concita el proceso se funda en la valoración que asume el trabajo como forma de reproducción social, material y simbólica en la sociedad argentina. Esta configuración cultural en torno al trabajo permite discriminar entre lo justo y lo injusto, promoviendo la acción colectiva y la tolerancia a la misma; planteando de este modo, límites a la mercantilización del trabajo.","palabras_clave":"Conflicto social|Economia moral|Trabajo|Empresas recuperadas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":638,"idioma_id":5,"titulo":"Competencias Socio emocionales en adultos mayores de la Ciudad de Buenos Aires.","resumen":"        Con el aumento de la población de adultos  mayores, se plantean importantes retos a nivel internacional. Los  estudios se focalizaron en factores demográficos, cognitivos y físicos, en  cambio, los emocionales fueron&nbsp;  escasamente investigados en esta etapa vital. El objetivo de este estudio  es evaluar el patrón de competencias socioemocionales en 53 adultos mayores (M  =69; DE =4.2), de ambos sexos, y comparar sus diferencias con 53  jóvenes adultos. A todos los participantes se les administró &nbsp;el Inventario de Competencias Socioemocionales  (ICSE; Mikulic, 2013). Los resultados indican que los adultos mayores muestran  significativamente mayor optimismo, asertividad, regulación emocional y autonomía,  a diferencia de los más jóvenes. Estos hallazgos pueden permitir diseñar intervenciones  focalizadas en el aprendizaje de nuevas competencias. Asimismo, permitirían  potenciar y mejorar competencias adquiridas pero no desarrolladas aún, con el  fin último de que el adulto mayor pueda contar con recursos para afrontar los  cambios inherentes a esta etapa vital.   ","palabras_clave":"COMPETENCIAS SOCIOEMOCIONALES|ADULTOS MAYORES|EVALUACIÓN PSICOLÓGICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":643,"idioma_id":6,"titulo":"A la recherche du public","resumen":"El presente artículo realiza una semblanza de las diversas articulaciones entre poéticas autorales y variantes de producción que impulsan una reconquista del público en el cine argentino contemporáneo. ","palabras_clave":"CINE|ARGENTINO|AUDIENCIA|POPULAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":644,"idioma_id":4,"titulo":"The peril of PCR inhibitors in environmental samples: the case of Didymosphenia geminata","resumen":"Since the introduction of polymerase chain reaction (PCR) biodiversity study has been significantly influenced by the chance of generating unprecedented amounts of molecular data. Although it is a robust technique, those applications requiring high sensitivity and reproducibility, that is PCR detection and quantitative PCR, can be negatively affected by PCR inhibition. This is particularly challenging for diverse kinds of samples included the environmental ones, which usually contain complex mixtures of a variety of inhibitory substances. The problem of PCR inhibition can be overcome, or ameliorated, by implementing adequate protocols of nucleic acids purification, internal controls and modern analytical approaches focused on PCR kinetics. Herein, we remark these procedures and describe the general techniques that can be used to optimize DNA extraction protocols for PCR applications. In addition, we show that PCR inhibition might have negative consequences in molecular studies of Didymosphenia geminata, an invasive microalga that have recently developed massive blooms in temperate regions worldwide, and provide general guidelines for dealing with this problem.","palabras_clave":"PCR inhibitors|environmental samples|DNA extraction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":646,"idioma_id":5,"titulo":"Conflicto y resistencia: recomposición de las formas de lucha de los trabajadores","resumen":"    Los procesos de  reestructuración productiva y flexibilización de las relaciones laborales  impactaron en las condiciones de trabajo, a partir de un vasto proceso de  retracción de conquistas laborales y pérdida de peso político de las  organizaciones sindicales en el marco de un disciplinamiento social acorde con  la ofensiva neoliberal vivida en los países de Latinoamérica durante la década  de los noventa. Frente a este escenario, el artículo recupera la potencialidad  interpretativa del conflicto para comprender lo acaecido en la última década,  analizando los flujos y reflujos en la conflictividad a partir del caso de  Argentina, los cambios en la morfología de la resistencia y el surgimiento de  nuevas expresiones que permiten interrogar los procesos neoliberales desde una  perspectiva dialéctica.  ","palabras_clave":"RESITENCIA|NEOLIBERALISMO|RELACIONES LABORALES|CLASE OBRERA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":647,"idioma_id":4,"titulo":"The role of microstructure in fatigue crack initiation of 9-12%Cr reduced  activation ferritic-martensitic steel.","resumen":"Electron back-scattered diffraction together with scanning and transmission electron microscopy were used to study nucleation of microstructural fatigue cracks in reduced-activation ferritic-martensitic steel, EUROFER 97. Cylindrical specimens were cycled over different plastic-strain ranges in order to evaluate the evolution of the dislocation structure. Surface-damage evolution was studied in smooth notched specimens by an optical in situ system equipped with a high-resolution camera. In order to understand the crack-initiation mechanism, the dislocation microstructure that develops in the near-surface regions of the notch was compared with that of the bulk. The results demonstrate a strong influence of lath-martensite boundaries on fatigue-crack nucleation.","palabras_clave":"Ferritic martensitic steel|LCF|Microstructure|Microcrack nucleation|EBSD technic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":648,"idioma_id":5,"titulo":"Construcción de espacios institucionales en Economía Social y Solidaria desde el ámbito universitario: El Caso del Proyecto CREES de la Universidad Nacional de Quilmes ? Argentina.?","resumen":".","palabras_clave":"Economía Social y Solidaria|Universidad|Territorio"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":649,"idioma_id":4,"titulo":"Rheological properties of aqueous dispersions of chia (Salvia hispanica L.) mucilage","resumen":"The viscoelastic and flow behavior of aqueous  dispersions with different concentrations of chia mucilage (Salvia hispanica L.) from Argentina  seeds was characterized. The mucilage was obtained by two methods: I, soaking-freezing-freeze  drying-sieving, and II, soaking-filtration-concentration-freezing-freeze  drying. The effect of mucilage concentration, temperature, pH, ionic strength  and presence of sucrose on the rheological properties of the aqueous  dispersions with the addition of NaCl or CaCl2 was also evaluated. All  the dispersion samples presented a shear-thinning behavior and a weak elastic gel-like structure because the storage modulus (G´) was larger  than the loss modulus (G´´) in the studied frequency range. The concentration  of mucilage was the variable with the most significant effect on k (consistency index), whereas the  presence of sucrose had the highest effect on n (flow behavior index) and tan &#948;. The type of salt and extraction method  significantly affected k, not  affecting n. Tan &#948; was affected mainly by the type of salt, and some interaction  was observed between both factors. Method II and NaCl provided a higher  consistency to the dispersions of chia mucilage. These results suggest that  chia mucilage could be applied in the production of foods that require  additives with thickening capacity, taking advantage of the zero calorific  value of this hydrocolloid.","palabras_clave":"SALVIA HISPANICA L.|CHIA|MUCILAGE|RHEOLOGY|SHEAR VISCOSITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":650,"idioma_id":4,"titulo":"Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis","resumen":"Olfactory epithelium has the capability to continuously regenerate olfactory receptor neurons throughout life. Adult neurogenesis results from proliferation and differentiation of neural stem cells, and consequently, olfactory neuroepithelium offers an excellent opportunity to study neural regeneration and the factors involved in the maintenance and regeneration of all their cell types. We analyzed the expression of BDNF in the olfactory system under normal physiological conditions as well as during a massive regeneration induced by chemical destruction of the olfactory epithelium in Xenopus laevis larvae. We described the expression and presence of BDNF in the olfactory epithelium and bulb. In normal physiological conditions, sustentacular (glial) cells and a few scattered basal (stem) cells express BDNF in the olfactory epithelium as well as the granular cells in the olfactory bulb. Moreover, during massive regeneration, we demonstrated a drastic increase in basal cells expressing BDNF as well as an increase in BDNF in the olfactory bulb and nerve. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.","palabras_clave":"NEUROTROPHINS|NEURAL STEM CELLS|OLFACTORY NEURONS|NEUROGENESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":651,"idioma_id":4,"titulo":"KARYOTYPES, HETEROCHROMATIN AND PHYSICAL MAPPING OF RDNA IN VINE CACTACEAE (HYLOCEREINEAE)","resumen":"We performed karyotype analyses on Hylocereineae species. Epiphyllum phyllanthus, Selenicereus aff. megalanthus and S. aff. setaceus were diploid, with 2n = 22 chromosomes, whereas  S. setaceus was tetraploid. Karyotypes were symmetrical with the formulas 11 m in E. phyllanthus, S. aff. setaceus and S. aff. megalanthus, and 22 m in S. setaceus. Chromosomes were small with the average length being 2.76 µm. Diploid species had two terminal satellites and tetraploids had four terminal satellites. The only bands associated with NOR were found in all specimens and were CMA+\/DAPI&#8722; bands. Pericentromeric heterochromatin was found in S. aff. megalanthus. The locations of the 18&#8722;5.8&#8722;26S rDNA sites in all species coincided with CMA+ bands. The signals of the 5S rDNA gene were located in paracentromeric regions on at least one locus in all taxa. Additional 5S loci were found in all species, with the exception of E. phyllanthus. One pair of 5S sites was co-localized with 18&#8722;5.8&#8722;26S loci in S. aff. setaceus and tetraploid S. setaceus, which is a new position for Cactaceae. The 18&#8722;5.8&#8722;26S rDNA loci seem to be highly conserved, in contrast with the 5S rDNA loci that were scattered throughout the genome.","palabras_clave":"Cactaceae|epífitas|cariotipo|cromosomas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":652,"idioma_id":4,"titulo":"A novel solid phase extraction ? Ultra high performance liquid chromatography?tandem mass spectrometry method for the quantification of ochratoxin A in red wines","resumen":"A novel and advanced technology on solid phase extraction column prior to liquid chromatography coupled to tandem mass spectrometry has been used for the determination of ochratoxin A in red wine samples. Due to the need of a reliable and rugged method according to current regulations and with the aim of minimize heuristic efforts associated with analytical method development, the statistical design of experiment was employed. On other hand, the method validation according to European Commission 2002\/657\/EC was achieved. The values obtained for decision limit (CCa), detection capability (CCb), limits of detection and cuantification were 0.07 lg L1, 0.14 lg L1, 0.13 lg L1 and 0.41 lg L1, respectively. The recoveries values were ranged from 95.7% to 107.2%. These values were compatible with the 2.0 lg L1 maximum allowable concentration limit established by different international regulations.","palabras_clave":"Ochratoxin A|Red Wine|Solid Phase Extraction|UPLC-MS\/MS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":653,"idioma_id":4,"titulo":"Reconstruction of a fossil forest reveals details of the palaeoecology, palaeoenvironments and climatic conditions in the late Oligocene of South America","resumen":"This research focuses on the three-dimensional reconstruction of an in situ forest based on fossil wood assemblages recovered in the Rancahué Formation (Upper Oligocene), Neuquén, Argentina. Atherospermataceae, Lauraceae, Nothofagaceae, Eucryphiaceae, Cunoniaceae and Myrtaceae specimens are described.","palabras_clave":"Late Oligocene|Fossil Forest|Three dimensional reconstruction|Multivariate anatomical analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":655,"idioma_id":4,"titulo":"Prevalence of Lactobacillus plantarum and Oenococcus oeni during spontaneous malolactic fermentation in Patagonian red wines revealed by polymerase chain reaction-denaturing gradient gel electrophoresis with two targeted genes","resumen":"The aim of this study was to evaluate fifty three Lactobacillus plantarum isolates obtained from a Patagonian red wine, molecularly identified and typified using RAPD analysis, in order to select starter cultures for malolactic fermentation (MLF). The results obtained suggest a considerable genetic diversity, taking into account that all Lb. plantarum isolates were obtained from one cellar and one vintage. Based on the capacity to tolerate a concentration of 14% ethanol in MRS broth for two days, eight isolates were selected for the subsequent analysis. The incidence of various wine stress factors (ethanol, acid pH, lysozyme and sulfur dioxide) on isolates growth was studied. Besides, glucosidase and tannase activities were evaluated, and the presence of genes involved in the synthesis of biogenic amines was examined by PCR. A previously characterized indigenous Oenococcus oeni strain was included with comparative purposes.  Differences in technologically relevant characteristics were observed among the eight Lb. plantarum selected isolates, revealing an isolate-dependent behavior. Detectable glucosidase and tannase activities were found in all isolates. The presence of genes encoding histidine and tyrosine descarboxylases and putrescine carbamoyltransferase was not detected. The ability of Lb. plantarum isolates to grow and consume L-malic acid in simulated laboratory-scale vinifications revealed that two of them could be considered as possible MLF starter cultures for Patagonian red wines. These isolates will be subjected to further analysis, for a final winery technological characterization.","palabras_clave":"Lactobacillus plantarum|Malolactic fermentatiom|Oenococcus oeni|Patagonian red wines|PCR-DGGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":657,"idioma_id":4,"titulo":"Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina","resumen":"Rodents are well-known hosts of Trypanosoma cruzi but little is known on the role of some caviomorph  rodents. We assessed the occurrence and prevalence of T. cruzi infection in Microcavia australis (?southern  mountain, desert or small cavy?) and its infectiousness to the vector Triatoma infestans in four rural  communities of Tafí del Valle department, northwestern Argentina. Parasite detection was performed by  xenodiagnosis and polymerase chain reaction amplification of the hyper-variable region of kinetoplast  DNA minicircles of T. cruzi (kDNA-PCR) from blood samples. A total of 51 cavies was captured in traps  set up along cavy paths in peridomestic dry-shrub fences located between 25 and 85 m from the nearest  domicile. We document the first record of M. australis naturally infected by T. cruzi. Cavies presented a  very high prevalence of infection (46.3%; 95% confidence interval, CI = 33.0?59.6%). Only one (4%) of 23  cavies negative by xenodiagnosis was found infected by kDNA-PCR. TcI was the only discrete typing unit  identified in 12 cavies with a positive xenodiagnosis. The infectiousness to T. infestans of cavies positive  by xenodiagnosis or kDNA-PCR was very high (mean, 55.8%; CI = 48.4?63.1%) and exceeded 80% in 44% of  the hosts. Cavies are highly-competent hosts of T. cruzi in peridomestic habitats near human dwellings  in rural communities of Tucumán province in northwestern Argentina.","palabras_clave":"TRYPANOSOMA CRUZI|CAVIES|MOLECULAR DIAGNOSIS|INFECTIOUSNESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":658,"idioma_id":5,"titulo":"Análisis de factores protectores en el abordaje del maltrato infantil desde la mirada clínica","resumen":"El objetivo de este trabajo fue explorar desde una mirada clínica la presencia de los factores protectores necesarios para otorgar el alta en un proceso terapéutico de casos de maltrato infantil confirmados, según la opinión de los profesionales especialistas en su abordaje. Desde la perspectiva cualitativa, se utilizó una muestra no probabilística ocasional constituida por 51 médicos, psicólogos, trabajadores sociales y otras disciplinas afines, especialistas en el abordaje de casos de maltrato infantil. Como instrumentos, se implementaron entrevistas y grupos de enfoque. Los resultados señalan la necesidad de la evaluación y fortalecimiento de las funciones parentales. Además, se rescataron notablemente los recursos y potencialidades propios del niño y de la familia, los recursos institucionales y los del equipo de salud. Esta propuesta se orienta a integrar la investigación con la reflexión acerca de las prácticas en el ámbito del maltrato infantil, con el fin de mejorar las intervenciones clínicas","palabras_clave":"Maltrato Infantil|Factores protectores|Abordaje Clínico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":659,"idioma_id":4,"titulo":"Interaction of modified celluloses and pectins with gluten proteins","resumen":"Physical and chemical techniques were applied to characterize the type of interaction between hydrocolloids and the gluten network in wheat dough, with and without NaCl. Modified celluloses (microcrystalline cellulose, MCC; carboxymethylcellulose, CMC, hydroxypropyl-methylcelluloses, HPMC) and pectins of low (LMP) and high (HMP) degree of substitution were assayed. Modified celluloses were employed at 1.5% (flour basis) and pectins at 2.0% (flour basis). By microscopy (SEM and CLSM), it could be observed that NaCl induced a more marked crosslinking and orientation of gluten network. On the other hand, the addition of hydrocolloids conducted to more open matrices. Molecular mobility was evaluated by H-NMR assays and significant effects of NaCl addition and hydrocolloid type were found on relaxation times (T2). In presence of salt, significantly higher relaxation times were observed when modified celluloses were added. Hydrocolloid addition strongly affected the secondary conformation of proteins as studied by FT-Raman. In absence of NaCl, control and MCC samples exhibited the higher &#61537;-helix conformation percentage (indicating a more ordered and compact structure), followed by dough with PAM, HPMCs, PBM and CMC. In general, doughs with modified celluloses and NaCl showed a decrease of &#61537;-helix conformation. CMC dough showed the smallest percentage of &#61537;-helix conformation, and the highest contributions of more unfolded structures. Doughs with pectins and NaCl showed similar percentages of &#61537;-helix to control one but an increase of random coil structure was observed. Electrophoresis assays confirmed that the presence of certain hydrocolloids (CMC) during gluten formation could affect protein interaction promoting subunits lability from the matrix.","palabras_clave":"wheat dough|modified celluloses|pectins|gluten network"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":661,"idioma_id":5,"titulo":"MACHOS QUE SE LA BANCAN: MASCULINIDAD Y DISCIPLINA FABRIL EN LA INDUSTRIA PETROLERA ARGENTINA","resumen":"En la Ciudad de Comodoro Rivadavia, Argentina, es un secreto a voces que en los espacios laborales de los petroleros suceden prácticas habituales y cotidianas entre hombres, tales como demostraciones de hombría, exposiciones de fortaleza, ?rituales de iniciación? o ?actos bautismales?. Cabe remarcar que es frecuente que estas ?bromas? posean claras connotaciones sexuales. Por consiguiente, este artículo analiza las prácticas y representaciones de los trabajadores petroleros vinculadas a la manufactura de la masculinidad. Nos interesa develar la relación entre masculinidad, políticas empresarias y disciplina fabril, proceso que culmina moldeando un sujeto fabril-petrolero-masculino acorde a los intereses de la producción.","palabras_clave":"petroleros|Masculinidad|Disciplina Fabril|Políticas empresarias"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":663,"idioma_id":5,"titulo":"Territorios de desigualdad. Avances sobre las formas de abordaje desde la perspectiva cualitativa","resumen":"Esta ponencia presentará avances de un estudio, que se encuentra en sus etapas iniciales, sobre la  configuración de áreas urbanas atravesadas por procesos de desigualdad.       Este proyecto tiene como objetivo inicial construir un corpus teórico y empírico de los procesos de urbanización periférica en  el AMGR resultantes de los procesos de desigualdad social.    El equipo de trabajo sostiene un enfoque que abreva en la teoría de la complejidad sobre las condiciones de desigualdad en materia de hábitat y particularmente en áreas deficitarias críticas del AMGR, en consonancia con la visión construida en el seno del instituto IIDVi, sede de un proyecto de mayor envergadura, y que articula actividades con el que aquí se expone.","palabras_clave":"HÁBITAT Y DESIGUALDAD|ESTUDIOS TEÓRICOS|ENFOQUES DE ABORDAJE|PERSPECTIVA INTEGRAL DEL HÁBITAT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":664,"idioma_id":5,"titulo":"Caracterización por HPLC y FTIR de los extractos acuosos de tres especies diuréticas del centro-oeste argentino","resumen":"Euphorbia serpens Kunth var. microphylla Müll. Arg. (Euphorbiaceae), Amaranthus muricatus (Moq.) Hieron. (Amaranthaceae), and Lithraea molleoides (Vell.) Engl. (Anacardiaceae) are traditionally used in Southern South America as diuretic plants. The first two are herbs commonly called 'yerbas meonas', while the latter, an evergreen tree, is known as 'molle de beber' or 'molle dulce'. This work tends to characterize the aqueous extracts (EAs) of these plant drugs, identifying and quantifying mannitol by High Performance Liquid Chromatography (HPLC ) as this alcohol would be primarily responsible for the diuretic activity have shown that the three entities, and identifying the species by comparing the spectrograms Spectroscopy Fourier transform infrared (FTIR ). The HPLC spectra show the characteristic areas for mannitol at retention time (Tr) 35.44 min., while the area under the respective curves allowed establishing varying concentrations between 23.056 g Kg-1 on the basis of dry matter in E. serpens var. microphylla, 4.638 g Kg-1 in L. molleoides, and 2.080 g Kg-1 in the case of A. muricatus; these figures explain the differences in diuretic potency described in the literature for these species. The FTIR spectrogram show relations CO\/CH characteristic for each species (8.42 for E. serpens var. microphylla; 9.28 for A. muricatus; and 11.18 for L. molleoides); the higher value corresponding to L. molleoides indicates a greater amount of oxygenates. The spectral data obtained allow us to contribute to the characterization of AEs of these species provide data for effective quality control of raw drugs and herbal medicines that contain these plants in its formulation.","palabras_clave":"Extractos de plantas diuréticas|HPLC|FTIR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":666,"idioma_id":5,"titulo":"LA REBELIÓN DE LOS URIBURU.  MOVILIZACIÓN POPULAR EN SALTA A MEDIADOS DE LA DÉCADA DE 1860","resumen":"El propósto de este artículo es demostrar que en la rebelión confluyeron diversas protestas de los sectores populares que fueron canalizadas por los comandantes militares y Legisladores federales para enfrentarse a los Uriburu y terminar con su plan para formar un gobierno de familia. El análisis de esta rebelión permite conocer las protestas de los soldados, las causas de su alzamiento y algunos rasgos del funcionamiento de una montonera. Esta amplia movilización muestra que la participación popular en la política salteña tenía profundas raíces, asentada en una intensa militarización y politización previas de milicianos. El estudio de la rebelión arrojará luz acerca de cómo la militarización fue capaz de integrar demandas populares en la competencia entre las elites políticas, y la existencia de una cultura política de base federal diferente a las provincias vecinas.","palabras_clave":"SALTA|MOVILIZACIÓN POPULAR|MILITARIZACIÓN|ORDEN POLÍTICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":667,"idioma_id":4,"titulo":"A revisit to the regions of some van den Bergh open clusters using photometric and astrometric parameters","resumen":"        We present  results of a study that combines photometry and astrometry for the open  clusters vdB80, vdB85 and vdB130. We apply a model which analyses the proper  motion distribution and the stellar density to find the kinematic parameters  and stellar membership in the region of the mentioned open clusters. The  astrometric data are obtained from UCAC4 catalogue. For each cluster, we report  the centre coordinates, the components of mean proper motion, the angular  diameter and the astrometric members. They are: vdB80: alfa = 97 ° . 73938 ± 0 ° . 00846, delta = - 9 ° . 66953 ± 0 ° . 01177,µ_alfa cosdelta = - 2.13 ± 0.47 mas \/ yr,µ_delta = - 0.95 ± 0.47 mas \/ yr,12´, 15 members; vdB85: a lfa= 101 ° . 71670 ± 0 ° . 00808, delta = 1 ° . 34392 ± 0 ° . 01253,µ_alfa cosdelta = 0.89 ± 0.43 mas \/ yr,µ_delta = 3.24 ± 0.43 mas \/ yr,8´ , 9 members; vdB130: alfa = 304 ° . 44001 ± 0 ° . 01407, delta = 39 ° . 32745 ± 0 ° . 00726,µ_alfa cosdelta = - 4.14 ± 0.25 mas \/ yr,µ_delta = - 5.15 ± 0.25 mas \/ yr,9´ , 9 members.&nbsp; We analyse the incidence of the proper motion errors in  the determination of the cluster parameters and of the stellar membership and  find that they are not significantly changed. We finally compare the  astrometric members with the photometric ones given in the literature.  ","palabras_clave":"(GALAXY:) OPEN CLUSTERS AND ASSOCIATIONS: GENERAL|(GALAXY:) OPEN CLUSTERS AND ASSOCIATIONS: INDIVIDUAL (VDB80, VDB85, VDB130)|ASTROMETRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":668,"idioma_id":4,"titulo":"Development of a novel neutron detection technique by using a boron layer coating a Charge Coupled Device","resumen":"This article describes the design features and the first test measurements obtained during the installation of a novel high resolution 2D neutron detection technique. The technique proposed in this work consists of a boron layer (enriched in 10B) placed on a scientific Charge Coupled Device (CCD). After the nuclear reaction 10B(n,alpha)7Li, the CCD detects the emitted charge particles thus obtaining information on the neutron absorption position. The above mentioned ionizing particles, with energies in the range 0.5-5.5 MeV, produce a plasma effect in the CCD which is recorded as a circular spot. This characteristic circular shape, as well as the relationship observed between the spot diameter and the charge collected, is used for the event recognition, allowing the discrimination of undesirable gamma events. We present the first results recently obtained with this technique, which has the potential to perform neutron tomography investigations with a spatial resolution better than that previously achieved. Numerical simulations indicate that the spatial resolution of this technique will be about 15 micrometers, and the intrinsic detection efficiency for thermal neutrons will be about 3 %. We compare the proposed technique with other neutron detection techniques and analyze its advantages and disadvantages.","palabras_clave":"Neutron detection|Neutron techniques|CCD|Charge Coupled Device"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":669,"idioma_id":4,"titulo":"Variation of physicochemical and sensory properties during the aging of yerba mate","resumen":"Yerba mate infusion is widely consumed in Argentina, Brazil and Paraguay. One of the processing steps used in Argentina is aging. The following three methods were used to age yerba mate: 1) air humidity and temperature-controlled aging; 2) temperature-controlled aging and 3) no control. The aim of this research was to determine the physicochemical and sensory attribute di\u000Berences when yerba mate was aged using these three methods. The concentration of ca\u000Beine, glucose, fructose, maltose and phenolic compounds and pH diminished in all three aging methods but by di\u000Berent percentages. The sensory attributes did not exhibit uniform behaviour. Astringency remained constant in the rst method and diminished in the other two. Bitterness increased in all three methods but by di\u000Berent percentages. Sweetness diminished in all three methods. Notably few correlations were determined between physicochemical and sensory attributes.","palabras_clave":"Ilex paraguariensis|yerba mate|sensory evaluation,|chemical compounds|aging"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":671,"idioma_id":5,"titulo":"Usos, prácticas y consumos culturales de nuevos medios en la Biblioteca Mayor de la Universidad Nacional de Córdoba. Un estudio de caso","resumen":"En el presente trabajo se estudiaron los usos, prácticas y consumos culturales de nuevos medios en la Biblioteca Mayor de la Universidad Nacional de Córdoba en el bienio 2012-2013. Se ponderó el impacto y las transformaciones en los servicios de proyección bibliotecológica a partir de su aggiornamiento a la convergencia tecnológica y la subsiguiente incorporación de los nuevos medios en el ámbito de la biblioteca. En la investigación se realizó un abordaje interdisciplinario enmarcado en una metodología mixta, cualitativa y cuantitativa, que implicó dos momentos: empírico y crítico-hermenéutico. El trabajo de campo se realizó mediante la aplicación de diversas técnicas comprendidas dentro del método etnográfico de ?estudio de caso? a través de: encuestas, entrevistas en profundidad, observación participante, triangulación de fuentes y recuperación de documentos institucionales.  Se concluye que debido a  la implementación de las tecnologías convergentes en la Biblioteca Mayor han surgido prácticas y usos de consumos culturales de nuevos medios que demandan que se establezcan políticas claras sobre el acceso, difusión y socialización de la información desde la gestión de la Biblioteca, por un lado, y que se promueva una  constante capacitación y perfeccionamiento del personal bibliotecológico para poder desarrollar nuevos servicios y para interactuar con los nuevos usuarios, por otro. Esto requiere de la institución una ponderación constante del capital humano en términos de costo-beneficio en relación a los servicios de proyección bibliotecológica.","palabras_clave":"Nuevos medios|Consumos culturales|Biblioteca universitaria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":674,"idioma_id":5,"titulo":"BREVES NOTAS SOBRE TERRITORIALIDAD CAMPESINA EN EL DESIERTO DE LAVALLE, MENDOZA (ARGENTINA)","resumen":"      El presente artículo toma como zona de  estudio al desierto de Lavalle, ubicado en la provincia de Mendoza, al centro  oeste de Argentina. Como su nombre lo indica, constituye una extensa planicie  árida con precipitaciones que oscilan entre los 80 y 130 mm. anuales y posee  temperaturas que, en verano, pueden alcanzar los 48° C. La cría de ganado  caprino es la actividad productiva más importante de la zona.      Este lugar ha sido analizado desde diversas  perspectivas e intereses teóricos, entre los que se destacan las modalidades de  acceso, uso y control de los recursos, principalmente hídricos, y sus  conflictos derivados; la pobreza y la exclusión social y su relación con  problemáticas ambientales (desertificación); el desarrollo local y sustentable;  así como la apropiación territorial, los procesos identitarios y la  organización comunitaria.    Luego de la revisión y lectura crítica  de distintas fuentes de información, nos propusimos comprender a la luz de las  categorías de territorio y territorialidad campesina de qué manera y en qué  contexto los pobladores del desierto de Lavalle, al desplegar formas de  reproducción social, definen y redefinen el territorio. Así, sostenemos que las  prácticas que sinergizan los habitantes del desierto, deben ser comprendidas en  un marco de mayor complejidad que involucre procesos económicos, sociales y políticos.          ","palabras_clave":"Territorio|Territorialidad Campesina|Reproducción social|Poder"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":675,"idioma_id":4,"titulo":"Candida dubliniensis and Candida albicans differentiation by colony morphotype in Sabouraud-triphenyltetrazolium agar.","resumen":"BACKGROUND:  Candida dubliniensis is a germ tube and chlamydoconidia producing Candida species that may be misidentified as Candida albicans. Molecular-based methods are the most reliable techniques for C. albicans and C. dubliniensis differentiation. However, accurate, quick and inexpensive phenotypic tests are needed to be used in low-complexity mycology laboratories.  AIMS:  To evaluate colony morphotypes on Sabouraud-triphenyltetrazolium agar as a tool for C. dubliniensis and C. albicans differentiation.  METHODS:  The morphology of 126 C. albicans and C. dubliniensis strains was evaluated and compared with their identification by molecular methods.  RESULTS:  The method showed 100% sensitivity and specificity when color and the presence or absence of large white mycelial halo was evaluated.  CONCLUSIONS:  Colony morphotype on Sabouraud-triphenyltetrazolium agar should be considered as a new tool to differentiate C. dubliniensis and C. albicans.  Copyright © 2013 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.","palabras_clave":"CANDIDA|CHLAMYDOCONIDIA|PHENOTYPIC|TRIPHENYLTETRAZOLIUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":676,"idioma_id":5,"titulo":"De Escuelita del monte a Escuela de la Capital: representaciones de arquitectura escolar y ciudad durante el primer peronismo.","resumen":"En   el contexto de la relación entre arquitectura escolar y política,   durante el Estado de Bienestar en Argentina a mediados del siglo XX, se   analiza la articulación de una escuela primaria pública en su aspecto   material, simbólico e institucional con procesos de transformación   urbana; en su paso de 'Escuelita del Monte' a 'Escuela de la Capital de   la Provincia del Chaco'; cuando recibe un edificio por el Plan   Quinquenal implementado durante el primer peronismo, y Resistencia   presenta un acelerado crecimiento por migraciones internas.       El   abordaje se realiza a través de las representaciones de docentes que   ingresan en la escuela en esa época, que complementan memorias oficiales   y la evolución catastral del área periférica, para una reconstrucción   más completa del entramado donde se inserta la arquitectura escolar, en   el que aún resuenan cuestiones como el clivaje urbano-rural y también la   relación escuela-hogar.","palabras_clave":"ARQUITECTURA |ESCOLAR|PERONISMO|PLAN|QUINQUENAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":677,"idioma_id":5,"titulo":"De la industria cultural a las industrias creativas: un análisis de la transformación del término y sus usos contemporáneos.","resumen":"El siguiente artículo toma como punto de partida al concepto de industria cultural desde sus principales exponentes, para exponer sus usos actuales. Este nació como concepto filosófico como parte de la obra de los autores representantes de la llamada Escuela de Frankfurt, Adorno y Horkheimer, con valiosos aportes de Benjamin. En la actualidad ha mutado su definición, siendo utilizado de manera instrumental por parte del Estado y organismos internacionales, para definir al grupo de sectores de producción cultural y simbólica de acuerdo a sus parámetros económicos. En este sentido, desde aquél concepto de industria cultural de los años cuarenta podremos ver que hay un recorrido en el cual se van transformando las posturas acerca de lo que el arte y la cultura posibilitan. La función social del arte va escondiéndose detrás de su inmersión cada vez más visible dentro de la producción mercantil, si bien en los últimos años la cultura aparece como motor de desarrollo económico e identitario. Esta transición será ilustrada con el caso argentino, dando cuenta de los cambios en el sector.Revista indexada en: NBR-Scielo, Latindex.Disponible en: http:\/\/qellqasqa.com.ar\/ojs\/index.php\/estudios\/article\/view\/75\/76","palabras_clave":"industria cultural|editoriales|tecnologías|arte"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":678,"idioma_id":4,"titulo":"Hydrogen evolution reaction on palladium multilayers deposited on Au(111): a theoretical approach","resumen":"We have investigated the electrocatalytic properties of multilayers of Pd epitaxially deposited on Au(111). In contrast to the numerous previous works in this area, we have focused on the kinetics of the electrochemical step for hydrogen adsorption (Volmer reaction) and determined its energies of activation. We have used a combination of density functional theory calculations and our own theory of electrocatalysis, which allows us to investigate the systems in an electrochemical environment. Contrary to our previous work with a submonolayer of Pd in Au(111), the activation barrier for the hydrogen adsorption process from proton is very low or almost zero for all bimetallic systems investigated. It is about 0.2 eV for pure Pd(111). In the case of two layers of Pd about 0.2 eV for pure Pd(111). In the case of two layers of Pd on Au(111) containing absorbed hydrogen in the subsurface, thethan for the other investigated systems. This is in agreement withoxidation with hydride Pd systems.adsorption free energy is less negative and the barrier lower experimental data that shows a larger activity for hydrogen","palabras_clave":"HYDROGEN ABSORPTION|Pd OVERLAYERS |Au SURFACE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":679,"idioma_id":5,"titulo":"TECTONICA CUATERNARIA EN EL RETROARCO ANDINO A LA LATITUD DEL  VOLCAN TROMEN (37°S)","resumen":"Estudios recientes focalizados en las vecindades del volcán Tromen, en el norte de la Provincia de Neuquén, indican la presencia de estructuras afectando rocas de edad cuaternaria. En particular, un análisis detallado del flanco occidental del volcán Tromen muestra amplias zonas de deformación neotectónica, de las cuales sólo habían sido reconocidos sus sectores frontales. Se detallan geometría y mecanismos asociados a las principales estructuras cuaternarias a través de los dos valles principales que afectan este flanco volcánico. La coexistencia de estructuras neotectónicas contraccionales y distensivas es descripta como un rasgo distintivo. Así, el campo de esfuerzos asociado a este conjunto de estructuras es discutido: Mientras algunos estudios previos puntualizan que la deformación sería de carácter contraccional, otros apuntan a un régimen predominantemente distensivo. Finalmente, se plantean alternativas a estos esquemas en base a los nuevos datos.","palabras_clave":"Neotectónica|Vulcanismo|Fases tectónicas|Compresión"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":680,"idioma_id":5,"titulo":"Evaluación de políticas públicas de informática educativa: sentidos, principios y criterios","resumen":"El artículo expone algunas reflexiones en torno a los sentidos, principios y criterios a considerar en la evaluación de una política pública de informática educativa. Las mismas son producto de  estudios evaluativos del Programa Conectar Igualdad (PCI) en los que participó la Universidad Nacional de Río Cuarto junto a otras universidades nacionales coordinadas por el Ministerio de Educación de la Nación. Este Programa se orienta a: a)  proporcionar una computadora a alumnas, alumnos y docentes de la educación secundaria, la educación especial y los institutos de formación docente bajo gestión estatal, b) capacitar a los docentes en el uso de dicha herramienta y c) elaborar propuestas educativas con el objeto de favorecer su incorporación en los procesos de enseñanza y aprendizaje.  En ese marco, el artículo se organiza en tres secciones.  La primera discute el sentido político y epistemológico del vínculo entre investigación evaluativa y políticas públicas. En la segunda parte, se exponen principios para la evaluación de políticas de informática educativa  considerados en los estudios sobre la implementación del PCI. Por último, se sintetizan algunos criterios o referentes emergentes de la evaluación del PCI, que podrían orientar el estudio de otros programas de inclusión digital, relativos a las dimensiones social, institucional y las prácticas de enseñanza y aprendizaje.","palabras_clave":"evaluación|políticas|informática|educativa"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":682,"idioma_id":5,"titulo":"PRIMER REGISTRO PREHISPÁNICO DE OBSIDIANAS EN EL PIEDEMONTE MERIDIONAL DE LA PROVINCIA DE TUCUMÁN (ARGENTINA): ANÁLISIS TECNOLÓGICO Y DE PROCEDENCIA","resumen":"Se presentan los resultados del estudio realizado sobre restos de obsidiana, los cuales constituyen los primeros registrados en contextos arqueológicos de las selvas meridionales de la provincia de Tucumán. Estos materiales fueron recuperados en capas estratigráficas del primer milenio DC correspondientes al sitio Santa Rosa, el cual se ubica en la base de las laderas orientales de la Sierra del Aconquija (Tucumán, Argentina). Se realizó un análisis técnico-morfológico de los especímenes en conjunto con análisis geoquímico mediante fluorescencia de rayos X (FXR) para determinar la procedencia de la obsidiana. Los resultados determinaron que la materia prima de la muestra, compuesta por desechos de talla,  procede de la cantera de Ona-Las Cuevas, la cual se ubica a ca.270 km al noroeste del sitio Santa Rosa, en el norte de la provincia de Catamarca, en la Puna meridional argentina. La gran distancia sitio-cantera nos lleva a proponer que las comunidades prehispánicas de estas tierras bajas habrían participado de esferas estables de interacción con grupos de áreas muy distantes, propiciando la circulación e intercambio de obsidianas dentro de la porción meridional del NO de Argentina.","palabras_clave":"Piedemonte de Tucumán|Obsidianas|Ocupaciones prehispánicas|Fluorescencia de Rayos X"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":683,"idioma_id":5,"titulo":"Comunicación temprana y vulnerabilidad social: estableciendo una agenda de investigación","resumen":"El desarrollo de la comunicación durante la infancia involucra un sinnúmero de procesos ligados a aspectos tanto ambientales como individuales. Un componente central del desarrollo comunicativo temprano es la atención conjunta. Su definición varía según los autores, pero su concepción habitual plantea que es la coordinación visual de dos individuos hacia un objeto de interés mutuo. Este fenómeno incluye la adquisición de comportamientos como: el seguimiento de mirada, la referencia social, gestos y el monitoreo. Por otro lado, la vulnerabilidad social es un factor de riesgo estudiado en relación con numerosas variables como la memoria, las funciones ejecutivas y distintas patologías. Sin embargo, existe escasez en los estudios orientados a conocer la relación entre las habilidades comunicativas tempranas y la vulnerabilidad social. En este sentido, se vuelve interesante profundizar en temas relacionados con el desarrollo temprano de estas capacidades, relevar literatura y pensar programas que apunten a paliar los efectos de un ambiente social vulnerable.","palabras_clave":"comunicación|infancia|desarrollo|vulnerabilidad social"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":684,"idioma_id":4,"titulo":"?Materiality between art, science and culture in the Viceroyalties (16th-17th centuries): an interdisciplinary vision towards the writing of a new colonial art history?","resumen":"El presente artículo presenta los resultados de la serie de seminarios internacionales e interdisciplinarios sobre materialidad, arte y cultura en América Colonial. Durante las tres reuniones llevadas a cabo en Buenos Aires\/Rosario (2011), Los Angeles (2012) y Buenos Aires\/Cordoba (2014) se abordaron los siguientes temas: enfoques teóricos y metodológicos sobre la investigación interdisciplinaria en torno a la materialidad: la plata como elemento principal en los discursos museográficos sobre arte colonial; plumas, resinas, insectos (cochinilla entre los más relevantes); flores o pasa de caña como características orgánicas y mediadores entre antiguas y nuevas prácticas; diferencias y similitudes entre técnicas españolas y americanas en pintura y escultura; la relación entre fuentes escritas y materiales; y pigmentos minerales y sus usos y significaciones locales.  A partir de los más de cincuenta excelentes trabajos presentados durante los seminarios, nos focalizaremos en cuatro estudios de caso que abordan de manera directa muchos de estos problemas. Todos estos casos parten de un trabajo interdisciplinario y demuestran la importancia de la dimensión material de las imágenes en relación con sus usos y significados.","palabras_clave":"MATERIALIDAD|ARTE COLONIAL|CIENCIA|CULTURA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":685,"idioma_id":5,"titulo":"La ciencia como garantía de la historia. José Ingenieros y su lectura de la novela de Sicardi","resumen":"Comotantos otros médicos argentinos de fines del siglo XIX, Francisco Sicardiescribe una serie de novelas, reunidas en Libroextraño (1902). La última novela de la serie lleva por título ?Hacia lajusticia? y suscita la crítica de José Ingenieros. Esa novela presenta undetallado cuadro de la sociedad porteña de entonces, con sus tipos máscaracterísticos, acordando con algunos de los principios del naturalismo.Ingenieros reconoce esas características, pero su crítica es lapidaria: apenasdebe proponer una resolución para el conflicto político, el autor abandona laciencia, traiciona los principios del naturalismo y confía el curso de la historiaa la intervención de una ilusión.Ennuestro trabajo analizamos la crítica de Ingenieros, intentando reconocer susentido y alcance. Consideramos algunos aportes del naturalismo literario en sudiscurso, pero advertimos que la preocupación central de este autor radica enla postulación del vínculo entre ciencia e historia. La literatura se pone alservicio de la ciencia y, desde allí, colabora en el desarrollo de la historia.","palabras_clave":"CIENCIA|LITERATURA|HISTORIA|JOSÉ INGENIEROS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":686,"idioma_id":5,"titulo":"Inserción laboral e incumbencias profesionales en graduados recientes de Trabajo Social de la UNR (1999-2008)","resumen":"Este artículo presenta los resultados preliminares de una investigación sobre graduados recientes de la Facultad de Ciencia Política y Relaciones Internacionales de la Universidad Nacional de Rosario, haciendo hincapié en datos referidos a los graduados de la Licenciatura en Trabajo Social. La información analizada se obtuvo a partir de la aplicación de una encuesta por cuestionario a egresados del período 1999-2008 y ofrece información sobre tiempo de duración de la carrera, período de egreso, situación ocupacional actual y al momento de graduación, cantidad de trabajos desempeñados a lo largo de la trayectoria ocupacional, formación extracurricular y de posgrado, así como las valoraciones que los graduados hacen tanto de la formación de grado recibida, como de la formación que consideran necesaria para un desempeño laboral-profesional deseado. Para este último aspecto se trabajó con la valoración que los egresados realizan de cada una de las incumbencias profesionales que figuran en el Plan de Estudio vigente.","palabras_clave":"TRABAJO SOCIAL|INSERCIÓN LABORAL|INCUMBENCIAS PROFESIONALES|GRADUADOS UNIVERSITARIOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":687,"idioma_id":4,"titulo":"Validity and Reliability of an Impedance Meter Device for the Assessment of Neuromuscular Rehabilitation Therapies","resumen":"During neuromuscular rehabilitation treatments,  it is necessary to evaluate the evolution of the patients using  objective parameters. This requires the design of devices that  generate valid and reliable data about the neuromuscular system. In this study, an impedance meter device is introduced,  that was designed to measure complex impedance for biomedical applications. Furthermore, the reliability of the device was  investigated, using reliability indexes derived from the estimation of the standard error of measurement (SEM), such as the  coefficient of variation (CV) and Bland-Altman limits of agreement (LoA). Reliability was tested using electrical models of the  neuromuscular system over a range of impedances from 40 to  1700 &#8486; and within a frequency interval ranging from 5 to 100  kHz. Results showed that the maximum difference between the  measured values and the calculated values (using precision instruments) was below 2,5%. Regarding reliability, typical error  (CV) was below 0,45% of the measured value, whereas the maximum error (LoA) was below 2,5% of the measured value. In  conclusion, the impedance meter device presented in this work  is sufficiently reliable for use in biomedical applications that involve measurement of complex impedances","palabras_clave":"NEUROMUSCULAR REHABILITATION|VALIDITY|IMPEDANCE MEASUREMENT|RELIABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":688,"idioma_id":4,"titulo":"Diferentiation Strategy of Agrifood with Impact on Economic and Social Development of vulnerable populations Case Study of Collective Trademark","resumen":"The competitiveness development  in agribusiness is based on implementing a value-added and marketing strategy  for the agrifood product that positions it into national and international market.  Instruments related to Intellectual Property, in order to be included in the property´s  right allows differentiation as an intangible asset, providing legal security  and guaranteeing that the income generated by such differentiation get back to  the farmers. In this case study referred to Rabbit production in the province  of La Rioja, Argentina, collective trademark is the right tool to apply since  it enables the construction of 'social capital'; bringing together  stakeholders around a production and marketing scheme, empowering them and  transcending the economic´s aspects. The implementation of trademark´s strategy  is reached after a process of knowledge´s construction that allows improvements  with the use of existing technologies and resources that helps to increase  scale´s economy, and the incorporation of entrepreneur´s associations. Those actions  have been supported and driven by local development´s policies of the local government","palabras_clave":"Agrifood|Trademark"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":689,"idioma_id":4,"titulo":"Doubly transitive groups and cyclic quandles","resumen":"We prove that for n&gt;2 there exists a quandle of cyclic type of size n if andonly if n is a power of a prime number. This establishes a conjecture of S.Kamada, H. Tamaru and K. Wada. As a corollary, every finite quandle of cyclictype is an Alexander quandle. We also prove that finite doubly transitivequandles are of cyclic type. This establishes a conjecture of H. Tamaru.","palabras_clave":"Quandles|Doubly transitive groups"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":690,"idioma_id":4,"titulo":"Catalytic properties of Au electrodes modified by an underlayer of Pd","resumen":"  \t\t\t      \t\t\t\t      \t\t\t\t\t    Bimetallic catalysts have manifold technological applications; their reactivity can greatly exceed that of the  original single metals. In this work, we investigate an ideal model-system consisting of a complete mono-  layer of Pd underneath the surface of Au(111). First, we investigate the stability of this system, and then  its interaction with hydrogen. We analyze in detail the energetics and the electronic interactions for the  Volmer step of the hydrogen evolution reaction (HER), and the further absorption below the surface layer  of gold. We combine Density Functional Theory based on computational techniques with the theory of  electrocatalysis.    \t\t\t\t  \t\t\t  \t\t","palabras_clave":"ELECTROCATALYSIS|DENSITY FUNCTIONAL THEORY|GOLD-PALLADIUM ALLOYS|HYDROGEN ADSORPTION|HYDROGEN STORAGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":691,"idioma_id":5,"titulo":"Temblores y otras manifestaciones de la energía. La Técnica del Sudarshan Kriya de El Arte de Vivir","resumen":"Cada año miles de personas en el mundo se inician al neo-hinduismo en la versión que la Fundación El Arte de Vivir ofrece, particularmente a través de su ?Seminario de Técnicas Respiratorias para el control del estrés y la ansiedad?. Durante los seis días que dura esta performance ritual, los participantes atraviesan toda una serie de preparativos -antes de sumergirse en la técnica respiratoria del Sudarshan kriya- a fin de producir transformaciones sobre su corporalidad y su subjetividad.  Este artículo aborda los sentidos que los participantes otorgan al proceso de ?desintoxicación? así estimulado, que derivaría incluso en una ?purificación?. Desarrolla cómo los efectos somáticos de la técnica son traducidos en términos de ampliación de la ?conciencia? y mayor atención intercorporal a la ?energía? propia y ajena. Frío, temblor, llanto, dolor de cabeza y mareos constituyen algunas de las manifestaciones corporizadas más frecuentemente mencionadas. Como parte de un trabajo de campo más extenso en torno de los sentidos del bien-estar en el circuito de practicantes de yoga en una ciudad argentina de escala intermedia, el objetivo de este trabajo consistió en comprender fenómenos indeterminados propios de la experiencia humana ?como los que el sudarshan kriya induce- recuperando su carácter intersubjetivo desde el paradigma del embodiment en antropología (más allá de un análisis del universo semiótico al que el ritual pertenece).","palabras_clave":"Neo-hinduismo|Técnicas|Energía|Corporalidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":693,"idioma_id":4,"titulo":"Impact of ozone exposure of the maternal environment on the viability and antioxidant content of grass seeds is affected by a vertically transmitted symbiotic fungus","resumen":"Ozone gas is a rising pollutant in the troposphere and is a consequence of human-driven global change.As a novel environmental stressor, interest in the impact of ozone on symbiotic systems is increasing.Focusing on the symbiosis between grasses and Epichloe species, we evaluated the effect of ozone exposure on the relative &#64257;tness of symbiotic and endophyte free plants and its transgenerational effects including seed performance and endophyte persistence","palabras_clave":"ozono|viabilidad |semillas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":694,"idioma_id":4,"titulo":"English Speakers Learning Spanish: Perception Issues Regarding Vowels and Stress","resumen":"The present pilot study examines both the perception of Spanish vowels \/a, e, o\/ in word ? final position and the perception of final and penultimate stress of words ending in those vowels by beginner American English learners of Spanish. Seventeen English speakers and seven native Spanish speakers participated in this study. The English speakers were exposed to 90 hours of Spanish lessons during a three?week course in Mar del Plata, Argentina, a Spanish speaking country. Participants? perception was assessed by pretest and posttest, which consisted of identification tasks with nonce words. The study yielded these results: (a) native English-speaking participants perceived Spanish vowels like native Spanish-speaking participants after a three-week language course; (b) Initially, English speakers received lower scores in the perception of stress than did Spanish speakers who served as a comparison (control) group; c) Three weeks after exposure to the language, the English speaking students performed like Spanish speakers in the perception of penultimate stress but not in the perception of final stress.   The article concludes that vowel perception is not a problem for English speakers learning Spanish while the perception of stress contrasts is a difficult challenge. More emphasis should be given to stress perception in Spanish programs for English speakers, as stress contrasts, together with vowels, are key to interpreting the meaning of a verb in the Spanish verbal morphology system.","palabras_clave":"PERCEPTION|VOWELS|STRESS|SPANISH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":697,"idioma_id":4,"titulo":"A multivariate geostatistical approach for landscape classification from remotely sensed image data","resumen":"This paper proposes a methodology to address the classication  of images that have been acquired from remote sensors. One common problem  in classication is the high dimensionality of multivariate characteristics.  The methodology we propose consists of reducing the dimensionality of the  spectral bands associated with a multispectral satellite image. Such dimensionality  reduction is accomplished by the use of the divergence of a modied  Mahalanobis distance. Instead of using the covariance matrix of a multivariate  spatial process, the codispersion matrix is considered which have some desirable  asymptotic properties under very precise conditions. The consistency and  asymptotic normality hold for a general class of processes that are a natural  extension of the one-dimensional spatial processes for which the asymptotic  properties were rst established. The results allow the selection of a set of  spectral bands to produce the highest value of divergence. Then, a supervised  maximum likelihood method using the selected spectral bands is employed  for landscape classication. An application with a real LANDSAT image is  introduced to explore and visualize how our method works in practice.","palabras_clave":"Multivariate spatial process|Spatial association|Codispersion matrix|Dimensionality reduction|Image classi"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":698,"idioma_id":5,"titulo":"TRATAMIENTO KINÉSICO  APLICADO EN LA NEUMONÍA POR ASPIRACIÓN EN CANINOS CON MIASTENIA GRAVIS ADQUIRIDA","resumen":"En Medicina Humana la kinesiología respiratoria (KR) es uno de los procedimientos complementarios mas frecuentes para tratar los trastornos causados por enfermedades broncopulmonares. En Medicina Veterinaria se está comenzando a implementar y corresponde a un conjunto de procedimientos que a través de la aplicación de medios fisicos, tienen como objetivo la prevención, la curación y estabilización de las alteraciones que afectan al sistema respiratorio, acompañando el tratamiento medicamentoso.  Miastenia gravis (MG) es una enfermedad neuromuscular autoinmune, de evolución crónica, siendo neumonía por aspiración una  complicación muy  frecuente. Se seleccionaron 15 pacientes caninos mestizos (12-36 kg) que asistieron a la Unidad de Neurología del Hospital Escuela de la Facultad de Ciencias Veterinarias de la Universidad de Buenos Aires, Argentina, con diagnóstico de neumonía por aspiración por megaesófago secundario a Miastenia Gravis. Se realizaron 10 sesiones de 15 minutos, con una frecuencia de 2 veces por semana. Se utilizó un oxímetro de pulso  pediátrico para la estimación de la saturación arterial de oxígeno. Se realizó la valoración clínica integrando score respiratorio y saturación de oxígeno.  De 15 pacientes caninos en la  sesión nº 1: 12\/15 caninos presentaban score leve y saturación de oxígeno 95 %. 3\/15 caninos con score moderado y  saturación oxígeno 94 %. Sesión n° 7: 13\/15 caninos presentaban score leve y saturación oxígenos 97%. 2\/15 caninos con score leve y saturación oxígeno 95%. Sesión nº 10: 14\/15 caninos con función respiratoria normal y 1\/15 caninos con score leve y saturación oxígeno 97 %.  Los resultados obtenidos en los caninos tratados con kinesiología respiratoria en forma complementaria al  tratamiento farmacológico fueron beneficiosos ya que se logró facilitar la eliminación de secreciones y reducir la posibilidad de infección, evitando complicaciones.","palabras_clave":"KINESIOLOGIA|RESPIRATORIA|CANINOS|MIASTENIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":701,"idioma_id":5,"titulo":"PRIMEROS REGISTROS DEL EVENTO ?LOMAGUNDI-JATULI? EN MÁRMOLES PALEOPROTEROZOICOS DEL BASAMENTO DE LAS SIERRAS SEPTENTRIONALES DE LA PROVINCIA DE BUENOS AIRES, CRATÓN DEL RÍO DE LA PLATA","resumen":"Sólo dos mármoles han sido identificados en el basamento de las Sierras Septentrionales; uno de ellos, el de San Miguel, es considerado en este trabajo. El mismo está alojado en un gneiss granatífero-biotítico intruido por cuerpos ígneos de &#820;2100 Ma. Presenta color blanquecino y tamaño de grano grueso; la asociación mineral calcita+diópsido+cuarzo indica un grado metamórfico en facies anfibolita alta. Análisis químicos revelan valores de CaO mayores al 50% y menores al 1% de MgO. La intrusión de filones, compuestos por cuarzo+plagioclasa+feldespato potásico, generó la formación de un skarn de wollastonita, vesubianita, grosularia y diópsido. Determinaciones de &#948;13C y &#948;18O en cristales de calcita del mármol develaron importantes anomalías positivas y un descenso de +5,42 a +4,26? en &#948;13C y de +17,12 a +13,84? en &#948;18O, desde el núcleo del mármol hacia el contacto con los filones. Dicha variación se explica por la cristalización de calcosilicatos a través de reacciones de desvolatilización durante los procesos metamórficos y metasomáticos. Los valores de &#948;18O de dos poblaciones de diópsido, distal y proximal al contacto con los filones, fueron utilizados conjuntamente con los de &#948;18O de calcita (en asociación paragenética) estableciendo dos pares geotermométricos calcita-diópsido: distal y proximal, obteniéndose temperaturas de 716°C (proceso metamórfico) y 451°C (proceso metasomático), respectivamente.  La concordancia de las características geológicas e isotópicas con los registros mundiales de carbonatos paleoproterozoicos y la edad estimada para el protolito del mármol de San Miguel, indican que éste habría sido un carbonato marino depositado durante el ?evento Lomagundi-Jatuli?.","palabras_clave":"MARMOL|ISÓTOPOS ESTABLES|PALEOPROTEROZOICO|LOMAGUNDI-JATULI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":702,"idioma_id":4,"titulo":"Accurate absolute parameters of the binary system V4089 Sgr","resumen":"We carried out a spectroscopic and photometric analysis of the binary  V4089 Sgr with the aim to obtain absolute masses and radii of the  components and to compare these parameters with stellar evolution  theoretical models. We took high-resolution spectra and measured radial  velocity using standard cross-correlations and a technique of spectral  disentangling. Absolute parameters of the components were determined  through the simultaneous fitting of measured radial velocities and  Geneva photometric data available in the literature. In this way we  obtained MA=2.584±0.008 Msun;,  MB=1.607±0.007 Msun;,  RA=3.959±0.013 Rsun;, and  RB=1.605±0.016 Rsun;. The comparison of  these parameters with two grids of theoretical models led to estimate  narrow ranges of possible values for system metallicity and age.  According to circularization theory it was not expected that the binary  had achieved a circular orbit as a result of tidal friction, so the null  eccentricity found is an interesting fact. On the other hand, we  measured the projected rotational velocity of both components and we  conclude that the primary is not synchronized with orbital motion.","palabras_clave":"eclipsing binaries|spectroscopic binaries"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":703,"idioma_id":5,"titulo":"Las estrategias en el lugar de trabajo del Partido Comunista en Argentina desde sus orígenes hasta 1943: células, comités de fábricas y comisiones internas","resumen":"La intención de nuestro trabajo es recuperar la experiencia impulsada por el Partido Comunista (PC) a partir de su creación y hasta la irrupción del peronismo en la organización del movimiento obrero en los sitios de producción. Durante años la creencia extendida en la historiografía asociaba la militancia en los espacios de base con el modelo sindical peronista y la instalación de las comisiones internas. Recientes investigaciones demostraron el extenso entramado organizacional de base generado por el proletariado fabril en las décadas anteriores a 1943. En dicho proceso coadyuvaron las corrientes de izquierda y en particular el PC que enarboló una política específica para su inserción en las fábricas y empresas. Los ejes que guían nuestra pesquisa son variados: las formas que adquirió esta militancia de base, el impacto de las líneas estratégicas partidarias, entre otros.","palabras_clave":"PARTIDO COMUNISTA|PERÍODO DE ENTREGUERRAS|ORGANIZACIÓN EN EL LUGAR DE TRABAJO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":704,"idioma_id":5,"titulo":"Perfil ejecutivo en niños con Trastorno por déficit de atención con hiperactividad","resumen":"RESUMEN. Introducción: El Trastorno por déficit de atención con hiperactividad (TDAH) es una las principales fuentes de derivación de los niños al sistema de salud. Los síntomas básicos son la desatención, hiperactividad e impulsividad. Se considera que una de las principales deficiencias del TDAH es el déficit en las funciones ejecutivas. Objetivo: Analizar el perfil ejecutivo en niños con TDAH y las relaciones con los subtipos diagnósticos. Método: Se evaluaron 90 niños con pruebas de funciones ejecutivas. La muestra clínica compuesta por 30 niños con diagnóstico médico de TDAH y la muestra control por 60 niños sin el diagnóstico. Resultados: Los niños con TDAH presentan un desempeño inferior en la mayoría de las pruebas que evalúan funciones ejecutivas, con ciertas diferencias entre los subtipos diagnósticos. Discusión: El TDAH se caracteriza como un trastorno con un estilo cognitivo propio y distintivo, con un déficit en las funciones ejecutivas.","palabras_clave":"TDAH |Funciones Ejecutivas |niños"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":705,"idioma_id":4,"titulo":"Measurement uncertainty estimated from accuracy assessment by using an in-house reference material: Two case studies for the extraction of total PAH in industrial wastewater sludges","resumen":"Measurement uncertainty is a required parameter to assure the reliability of analytical results because many management decisions (scientific, technical, regulatory, and economical) are based on the results of analytical processes. Moreover, since ISO 17025 accreditation requirements specify protocols for estimating uncertainty in measurements, the community of the analytical laboratories had to start reporting their results with the corresponding associated uncertainty. Several approaches have been reported for estimating uncertainty, although the evaluation of uncertainty from the method accuracy assessment has the advantage to not require extra efforts for the analysts. In-house reference materials are useful both to perform the validation studies and to estimate the measurement uncertainty when certified reference materials are not available. In this study, we presented a practical methodology to calculate the uncertainty of the analytical results when the accuracy assessment is performed by using an in-house reference material developed to fit this purpose. For evaluating the suitability of this approach, we applied it to the assessment of two extraction methods for total PAH determination in industrial sludges. The uncertainty budgets revealed that the uncertainty arising from subsampling gives decisive contributions to the overall uncertainty (from 18% to 69%), depending on the homogeneity in the sample preparation process.","palabras_clave":"Measurement uncertainty|In-house reference material|Total PAHs|Industrial wastewater sludge"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":707,"idioma_id":4,"titulo":"Motivation and Commitment to Volunteering in a Sample of Argentinian Adults: What is the Role of Generativity?","resumen":"This study explores the motivations and commitment to volunteering in a sample of Argentinian adults, and it analyzes the role of generativity. The sample consisted of 200 volunteers who were purposively selected from five volunteer organizations in the city of Co´rdoba (Argentina).  Participants were assigned to three age groups: young volunteers (18?39 years old), middle-aged volunteers (40?59 years old), and older volunteers (60 or plus years old). The motivations of ??values?? and ??understanding?? obtained the highest scores. No relevant differences were found between age groups in the motivations and commitment to volunteering. Generative concern showed more predictive value for motivations and commitment to volunteering than any of the sociodemographic variables considered in the study. The results are discussed at the light of considering volunteering as an expression of generativity in different stages of the life cycle.","palabras_clave":"Generativity|Volunteering"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":708,"idioma_id":4,"titulo":"Echinococcus granulosus antigen B: A Hydrophobic Ligand Binding Protein at the host-parasite interface","resumen":"Lipids are mainly solubilized by various families of lipid binding proteins which participate in their transport between tissues as well as cell compartments. Among these families, Hydrophobic Ligand Binding Proteins (HLBPs) deserve special consideration since they comprise intracellular and extracellular members, are able to bind a variety of fatty acids, retinoids and some sterols, and are present exclusively in cestodes. Since these parasites have lost catabolic and biosynthetic pathways for fatty acids and cholesterol, HLBPs are likely relevant for lipid uptake and transportation between parasite and host cells. Echinococcus granulosus antigen B (EgAgB) is a lipoprotein belonging to the HLBP family, which is very abundant in the larval stage of this parasite. Herein, we review the literature on EgAgB composition, structural organization and biological properties, and propose an integrated scenario in which this parasite HLBP contributes to adaptation to mammalian hosts by meeting both metabolic and immunomodulatory parasite demands","palabras_clave":"Echinococcus granulosus antigen B|Hydrophobic Ligand Binding Protein"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":710,"idioma_id":5,"titulo":"Difusión social de modelos de comportamiento interpersonal de jóvenes, en diarios de la ciudad de Córdoba?","resumen":"El propósito de  este artículo es presentar los resultados de un estudio llevado a cabo con el objetivo de  identificar y describir el modelo de comportamiento interpersonal que presentan  los medios masivos de comunicación gráfica sobre los jóvenes en Córdoba  Capital. Para ello se utilizó un diseño descriptivo de observación documental  (Sierra Bravo, 2005). La muestra estuvo compuesta por las ediciones impresas de  mayo y junio de 2010 de las editoriales  La Voz del Interior y La Mañana de Córdoba. Para el análisis de datos se  utilizó la metodología de análisis de contenido (Krippendorff, 1990), coherente  con la metodología inductiva de identificación de frames (Igartua y Humanes,  2004).La frecuencia de presentación de  los encuadres en las noticias conformó un modelo donde prevalecieron las  conductas anti-sociales sobre las pro-sociales, siendo la más observada la  agresión física. Los resultados son discutidos desde la Teoría Social Cognitiva  (Bandura, 1987) y la teoría de los encuadres noticiosos o frames (Cheng y cols,  2009; de Vresse, Peter y Semetko, 2011; Macias Rodríguez, 2009).","palabras_clave":"Jóvenes|Conductas antisociales |Conductas pro-sociales|Medios de comunicación gráfica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":711,"idioma_id":4,"titulo":"Reproductive biology of Vasconcellea quercifolia A. St.-Hil. (Caricaceae), a moth-pollinated 'highland papaya'","resumen":"Vasconcellea species, often referred to as highland papayas, are wild relatives of common papaya (Carica papaya) widely distributed in tropical America, with a preference for cooler climates. The genus deserves special attention as its species show potential as raw materials in the tropical fruit industry, papain source or as genetic resources in breeding programs of C. papaya. However, studies related to breeding system and pollination biology of genus are still unexplored. We characterize the reproductive biology of dioecious Vasconcellea quercifolia, one of the southernmost Caricaceae. According to floral shape and presence of nectar, we expected that this species had a specializated pollination system, with moths as the primary pollinators. To test this, we studied floral biology, floral visitors, pollinators, and breeding system of this species. Controlled pollination experiments show that V. quercifolia is a xenogamous species that depends on its pollinators to set fruits (18 and 79 % fruit and seed set under open-pollination, respectively). Anemophily and apomixis occur very seldom. The treatments of exclusion of floral visitors and pollen load analysis showed that the main pollinators are moths belonging to Arctiidae, Noctuidae, and Pyralidae. The only reward for pollinators is the nectar produced by male flowers. Female flowers are pollinated by deceit because they do not produce floral rewards.","palabras_clave":"VASCONCELLEA|REPRODUCTIVE|POLLINATED|PAPAYA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":713,"idioma_id":4,"titulo":"FTIR gas kinetic study of the reactions of ozone with a series of hexenols at atmospheric pressure and 298K","resumen":"Relative rate coefficients of the reactions of O3with (Z)-3-hexen-1-ol, (E)-3-hexen-1-ol and (E)-2-hexen-1-ol have been determined in an environmental chamber with in situ FTIR detection of thereactants at 298 K and 760 Torr. The following rate coefficients (in units of 10&#8722;17cm3molecule&#8722;1s&#8722;1)have been determined: (6.04 ± 0.95) for (Z)-CH2(OH)CH2CH CHCH2CH3; (5.83 ± 0.86) for (E)-CH2(OH)CH2CH CHCH2CH3; (5.98 ± 0.73) for (E)-CH2(OH)CH CH(CH2)2CH3. This is the first kineticstudy for the reactions of O3with (E)-2-hexen-1-ol and (E)-3-hexen-1-ol. Reactivity trends are devel-oped and the atmospheric persistence of these compounds is calculated based on the rate coefficients.","palabras_clave":"Kinetics|Ozonolysis|C6-unsaturated alcohols|FTIR-atmospheric photoreactor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":714,"idioma_id":5,"titulo":"Estructura y dinámica de la comunidad íctica del Arroyo Yabotí. Reserva de Biosfera Yabotí. Misiones (Argentina)","resumen":"El arroyo Yabotí se ubica en la Selva Paranaense, punto caliente en cuanto a la necesidad de conservación. El objetivo fue determinar la estructura y funcionamiento de la comunidad íctica del arroyo Yabotí en base a parámetros de diversidad, similitud, dominancia, y biología reproductiva y alimentación. Se realizaron cuatro campañas de pesca experimental entre noviembre 2006 y noviembre 2007 en tres sectores del arroyo utilizando una batería de diez redes de espera. La diversidad (H´) fue de 3.55 bits, no hubo diferencia significativa (P<0.05) entre los sectores de la cuenca. Se capturaron 1327 individuos de 65 especies. La mayor similaridad fue entre la cuenca alta y baja, donde las especies dominantes fueron Apareiodon piracicabae y Leporinus striatus. La mayor abundancia y diversidad específica se registró en la cuenca baja durante el invierno. Especies como A. piracicabae, L. striatus, Pimelodus absconditus, Steindachnerina brevipinna y Acestrorhynchus pantaneiro fueron dominantes durante la mayor parte del año. Los insectos y materia vegetal de origen alóctono fueron los recursos más consumidos, dominaron las especies omnívoras y piscívoras. La cuenca baja fue la de mayor actividad reproductiva, registrándose la mayor RGS y hembras maduras de A. pantaneiro, A. piracicabae L. striatus. La actividad reproductiva fue mayor durante el invierno y la primavera.","palabras_clave":"PECES DE AGUA DULCE |DIVERSIDAD|SIMILITUD|REPRODUCCIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":715,"idioma_id":5,"titulo":"De la Educación a Distancia a la Educación en Línea","resumen":"Reseña de libro:El contenido del libro Dela Educación a distancia a la educación en línea: aportes a un campo enconstrucción atraviesa justamente esta zona detránsito, de andamio teórico y revisión donde se va desprendiendo de unadenominación y conceptualización asociada a la educación a distancia y sedirige hacia otra nueva, desde la que abrir la arquitectura que propicie lacomposición genuina del ámbito de la Educación en Línea (EeL).Sin embargo, la obra va más allá de lo estrictamente considerado como ?educación enlínea?, dado que trata temas integrales que incumben a la educación como áreade saber genérico, abordando los nuevos formatos de circulación que puede transitarla experiencia educativa en los contextos digitales en que se produce el hechopedagógico hoy, a la vez que nutre y significa con nuevos atributos estamodalidad específica.","palabras_clave":"EDUCACIÓN A DISTANCIA|EDUCACIÓN EN LÍNEA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":716,"idioma_id":5,"titulo":"La economia politica de la armonizacion: Transferencias fiscales para el sostenimiento de los sistemas previsionales provinciales. El caso de Córdoba 2002-2008","resumen":"Las  relaciones fiscales y la distribución de recursos de los gobiernos  centrales hacia los gobiernos subnacionales en los sistemas federales  han sido ampliamente abordadas por la literatura que se ocupa de los  factores políticos que explican sus características y su dinámica.                    En  el caso argentino, es hoy ampliamente aceptado que, dentro de los  márgenes que establecen determinados arreglos institucionales que  regulan aquellas relaciones, estas se establecen en el marco de una  puja entre los intereses político-electorales de los gobernadores,  por un lado, y los de los presidentes, por el otro. Los primeros  intentan explotar los recursos federales incrementando los gastos en  su propia jurisdicción a ser financiados con recursos del gobierno  central (al tiempo que son renuentes a incrementar la presión fiscal  en sus propios distritos). El éxito en esta estrategia implica  potenciales grandes beneficios para consolidar su posición política  a nivel local y, en buena medida como consecuencia de ello, a mejorar  las perspectivas de su carrera política a nivel nacional.","palabras_clave":"DISTRIBUCIÓN|COALICIONES|FEDERALISMO|POLÍTICAS PÚBLICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":718,"idioma_id":5,"titulo":"LOS ESTUDIOS CULTURALES Y SU APORTE AL CAMPO DEL CURRICULUM","resumen":"El propósito que anima el presente trabajo es sistematizar algunos aspectos en relación a los estudios culturales y plantear posibilidades de incorporar sus aportes al campo curricular.   Con la intención indagar y contextualizar su nacimiento, se hace referencia a la emergencia del paradigma de los estudios culturales, su desarrollo en el tiempo, con los diferentes representantes y algunos giros conceptuales que se fueron produciendo.  Se toman en consideración cuestionamientos a los EC, por su carácter europeizante,  así como cuatro momentos importantes del desarrollo de la versión Latinoamérica, desde su génesis y avanzando en sus particularidades y especificidades propias de la coyuntura histórica de la región. Luego, se consideran los cambios culturales acontecidos y los desafíos que esto ha creado en las comunidades educativas, desafíos que imponen la necesidad de repensar la escuela y el currículum en consonancia a ellos. Esto implica, sin lugar a dudas, la renovación de las prácticas curriculares de manera que permitan focalizar su atención en los nuevos emergentes sociales.","palabras_clave":"ESTUDIOS CULTURALES|CURRICULUM|ESCUELA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":719,"idioma_id":5,"titulo":"HOSTIGAMIENTO LABORAL: INTRODUCCION DE UNA CUARTA DIRECCION EN UNA INSTITUCION DE LEY","resumen":"Dada la importancia del ?hostigamiento laboral? en el campo de la Psicología Jurídica, este trabajo profundiza su delimitación, estableciendo una relectura crítica del enfoque tri direccional del mismo. Mediante el relevamiento exhaustivo de fuentes documentales, secundarias y el corpus normativo, el análisis de contenido y el análisis de un caso intrínseco referido a una fuerza de seguridad, se recorta una cuarta dirección del hostigamiento laboral: la institucional. De esta manera, se divorcia la explicación etiológica del agente penalmente responsable, cuya superposición adolecería del defecto de importación de la lógica jurídica al campo de la psicología. Se considera que este aporte permite optimizar recursos reflexivos a la hora de diseñar estrategias de intervención. Se toman en cuenta los aportes de Abajo Olivares (2007), Basile (2007), Hirigoyen (2000, 2001), Piñuel y Zabala (2001).","palabras_clave":"PSICOLOGIA JURÍDICA|MOBBING|PERSPECTIVA INSTITUCIONAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":720,"idioma_id":4,"titulo":"The combined effects of Pseudomonas fluorescens CECT 844 and the black truffle co-inoculation on Pinus nigra seedlings","resumen":"The inoculation with mycorrhizal fungi and rhizobacteria has been demonstratedtoimprovethemorphologyandphysiologyofseedlingsusedinthereforestationofMediterraneanareas,aswellastofavorthereintroductionofmycorrhizalfungi into such environments.&nbsp; Pinus nigra subsp.&nbsp; salzmannii, currentlyused in the reforestation of Mediterranean regions, may host an ectomycorrhizalsymbiosiswiththeAscomycetesfungusTubermelanosporumVitt.(blacktruffle).&nbsp;Previous&nbsp; investigations&nbsp; demonstrated that&nbsp; the inoculation of&nbsp; Pinushalepensis seedlings with the rhizobacterium Pseudomonas fluorescens CECT844 and T. melanosporum improved plant growth and N absorption, and doubledtherateofmycorrhizationofT.melanosporum.Inthepresentwork,westudiedthe morphophysiological response of&nbsp; P.&nbsp; nigra&nbsp; seedlings grown underwell-watered&nbsp; conditions&nbsp; in a&nbsp; nursery&nbsp; to the&nbsp; combined inoculation with&nbsp; T.melanosporum and\/or P. fluorescens CECT 844. Five months after inoculation,growth parameters (seedling height, basal&nbsp; diameter, and shoot and root dryweight), mycorrhizal colonization, water parameters (osmotic potential at bothfull and zero turgor and modulus of elasticity), and total contents and concentrationsofN,P,andKweremeasuredintherootsandshootsofseedlings,andtherootgrowthpotentialswasestimated.TheadditionofP. fluorescens CECT844 did not significantly improve the mycorrhizal colonization by T. melanosporumonP.nigraseedlingroots.Additionally,P.fluorescensinoculationcausedfewsignificantimprovementsingrowthandwaterparametersofseedlings.Moreover,&nbsp;apparently opposing effects on P uptake were observed betweenthe two inoculations.&nbsp; The use of&nbsp; P.&nbsp; fluorescens CECT 844 as&nbsp; a MycorrhizalHelper Bacterium (MHB) through different mechanisms and in different environmentalconditionsisdiscussed.","palabras_clave":"Rhizobacteria|black truffle|Mycorrizal|Mycorrizal helper bacteria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":722,"idioma_id":5,"titulo":"La mirada del extranjero. Reflexiones de José Ortega y Gasset sobre la psicología de los varones y las mujeres argentinas.","resumen":": La psicología de los argentinos y argentinas fue una temática que atrajo la curiosidad de algunos observadores extranjeros. Entre los que visitaron la Argentina y escribieron sobre ella en la primera mitad del siglo XX encontramos al norteamericano Waldo Frank, al alemán Keyserling y al filósofo español Ortega y Gasset, este ultimo viajo al país en tres oportunidades generando agudas observaciones acerca de la idiosincrasia de este pueblo, dejando constancia de sus meditaciones en Intimidades, ensayo que forma parte de El Espectador. El presente trabajo tiene como objetivo analizar, a partir de dichos escritos, las reflexiones que el filósofo español realizó acerca de las diferencias entre la psicología de los varones y las mujeres argentinas en la conformación de la identidad nacional, entendiendo una asimetría fundamentada en la idea de nuestro país como un pueblo joven.","palabras_clave":"Ortega y Gasset|Psicología del argentino|diferencia sexual"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":723,"idioma_id":5,"titulo":"MANEJO DE VICUÑAS SILVESTRES EN SANTA CATALINA, JUJUY: INVESTIGADORES Y POBLADORES EN BÚSQUEDA DE LA SUSTENTABILIDAD Y EL BUEN VIVIR.","resumen":"El manejo de la vicuña en silvestría presenta un desafío para los científicos y los pobladores andinos. Con buenas prácticas, el manejo de la especie puede considerarse como un modelo de uso sustentable, dado que integra la conservación de la vicuña y su hábitat con el potencial desarrollo local. Desde el año 2010, el grupo VICAM (Vicuñas, Camélidos y Ambiente) se encuentra desarrollando un Plan de Conservación y Uso de Vicuñas en silvestría conjuntamente con la Cooperativa Agroganadera de Santa Catalina (Jujuy, Argentina), en el marco de una fructífera sinergia entre científicos, estudiantes y pobladores  locales. Este Plan integra recomendaciones técnicas basadas en investigaciones científicas con saberes locales, y está regido por la valoración ética de la conservación de la Biodiversidad y el Buen Vivir. El objetivo de este trabajo consiste en presentar los lineamientos del Plan Local de Conservación y Uso de vicuñas en Santa Catalina, detallando las actividades de captura y esquila llevadas a cabo en los años 2012 y 2013. La puesta en práctica de este Plan permitió, mediante el manejo adaptativo y la aplicación de estrictos protocolos de bienestar animal, que dichas experiencias de ?neo-chakus? se llevaran  a cabo con un mínimo estrés y nula mortalidad animal.","palabras_clave":"VICUÑAS|MANEJO ADAPTATIVO|SUSTENTABILIDAD|BUEN VIVIR|BIENESTAR ANIMAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":725,"idioma_id":5,"titulo":"Repensando el debate monismo vs. dualismo en la antropología del cuerpo","resumen":"Al interior de la antropología del cuerpo, el debate ?monismo vs. dualismo?, que involucra la reflexión comparativa de los vínculos cuerpo-mente, persona-mundo en diferentes sociedades, históricamente ha sido materia de discusión entre los especialistas. El objetivo de este trabajo es problematizar dos aspectos de dicho debate: a) El pensamiento de Descartes, interlocutor omnipresente en la discusión, es caracterizado parcialmente, obviándose aspectos relevantes de su obra que permiten matizarla y b) Los datos etnográficos, como las cosmologías tríadicas  presentes en varios grupos humanos, dan cuenta de una variabilidad empírica que no se deja encerrar en la acotada oposición monismo vs. dualismo.","palabras_clave":"CUERPO|HOLISMO|NOCION DE PERSONA|DUALISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":726,"idioma_id":5,"titulo":"La justicia de menores desde la mirada de los jueces. Valoraciones y representaciones sobre la ley y la administración de justicia","resumen":"El presente artículo condensa las opiniones y valoraciones que los jueces de menores tienen sobre algunos aspectos del quehacer judicial en la administración de justicia sobre  personas menores de edad. En la pretensión de construir una cartografía moral de las prácticas judiciales , realicé una reconstrucción de las mismas a través de los discursos hablados y escritos de los jueces. Realicé entrevistas en profundidad y un análisis cualitativo y lingüístico de sentencias. Así pude confrontar aquello que los que los jueces enuncian, y aquello que los jueces realizan en su labor de administración de justicia y dejan plasmado en las sentencias. También yo he reconstruido el discurso y el relato que los magistrados construyen sobre sus acciones.   En este artículo me concentraré en los relatos de los jueces a través de la reconstrucción de sus opiniones en las entrevistas realizadas. El trabajo de campo se realizó en los Tribunales orales de menores de la Ciudad de Buenos Aires. La reconstrucción  se organizó en base a tres ejes: la percepción de los jueces sobre la delincuencia juvenil; la regulación legal sobre las personas menores de edad ( Régimen penal de la minoridad\/ley 22.278) y las representaciones de los jueces sobre el fin de la pena.  He podido constatar que en las valoraciones de los jueces emergen cosmovisiones preexistentes sobre el bien, la moral, lo bueno, lo correcto y lo normal. Asimismo, los jueces albergan consensos valoradas positivamente. Estas cosmovisiones marcan pautas de distribución en torno a la norma.","palabras_clave":"JUSTICIA DE MENORES|ADMINISTRACIÓN DE JUSTICIA|DELINCUENCIA JUVENIL|FINALIDAD DE LA PENA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":728,"idioma_id":4,"titulo":"Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits.","resumen":"BACKGROUND: The ingestion of caustic substances remains an important public  health issue worldwide. Children represent 80% of the ingestion injury population  globally. Accidental alkaline material accounts for most caustic ingestions.  There is no conclusive evidence of tissue damage and stricture protection of a  nasogastric-tube with a solid dilator in the literature, therefore it was  hypothesized that early intraesophageal tube placement does not cause additional   histopathologic damage and prevents strictures.  METHODS: An exploratory study on experimental caustic esophageal burns in a  rabbit model was designed. In the treated group a silicone tube was placed  immediately after causing the burns, while the untreated group followed the  natural course of the burn. On the twenty-secondday, an esophagectomy was  performed on all animals for microscopic (Histopathologic Damage Score and  Stenosis Index) and macroscopic analysis.  RESULTS: Forty animals were randomly divided into two groups. The Histopathologic  Damage Score was 3.7±1.1 in the treated group versus 3.9±1.2 in the untreated  group (p=.9690). The Stenosis Index was 0.6±0.1 in treated rabbits versus 2.3±0.2  in untreated (p<.0001).  CONCLUSION: The early placement of an intraesophageal tube with solid dilator  prevents stenosis formation and does not produce greater tissue damage.","palabras_clave":"nasogastric tube|solid dilator |esophageal burns|rabbits"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":729,"idioma_id":5,"titulo":"?La construcción de ciudadanía en la escuela secundaria: convivencia, regulación de la participación juvenil y nuevas dinámicas de desigualdad?","resumen":"      Este trabajo busca problematizar en  torno a las formas de construcción de la ciudadanía en la escuela secundaria, Para abordar esta temática la presentación está  organizada en tres apartados. En un primer momento, se presenta una breve  caracterización de la situación del nivel medio donde se hace referencia a las  tasas de cobertura, se describe el proceso de fragmentación educativa y se  presentan las distintas tensiones que enfrenta la  escuela secundaria en la actualidad. A continuación, a partir de avances  preliminares de una investigación desarrollada en cuatro instituciones ubicadas  en la Provincia de Buenos Aires nos preguntamos por la expansión del nuevo  sistema de convivencia escolar. Para ello se describen y analizan diferentes  ?situaciones? o escenas ocurridas en las escuelas con la intención de prestar  atención a las formas de regulación de la participación estudiantil, particularmente  a las cuestiones que se especifican y las referencias a los derechos de los y  las jóvenes. Para ello prestamos atención a tres aspectos: las tradiciones  políticas existentes en las instituciones, los grados de  heterogeneidad\/homogeneidad de la matrícula escolar y los repertorios de acción  a los que apelan los y las estudiantes; indagando en las diferencias entre  sectores sociales.   ","palabras_clave":"ESCUELA SECUNDARIA|CIUDADANÍA|INCLUSIÓN|CONVIVENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":730,"idioma_id":4,"titulo":"Fracture of pearlitic ductile cast iron under different loading conditions","resumen":"In this study, fracture surfaces of pearlitic ductile iron generated under impact, bending and fatigue tests were characterised and compared. The fracture mechanisms in each case were identified from the observation of scanning electron microscopy images, and the characteristic topographic features were quantitatively and qualitatively evaluated. Cleavage was the predominant fracture mechanism for impact loading at all test temperatures and for slow bending testing. On the other hand, under fatigue loading, the fracture surfaces showed a mix of cleavage and ductile striation areas. A complex but reliable methodology for the determination of the direction of propagation of the main crack was also proposed, based on a careful analysis of the river patterns along the cleavage planes.","palabras_clave":"Fracture surface|Bending|Fatigue|Impact"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":731,"idioma_id":4,"titulo":"Formulation of enriched macro elements using trigonometric shear deformation theory for free vibration analysis of symmetric laminated composite plate assemblies","resumen":"The formulation of an enriched macro element suitable to analyze the free vibration response of composite plate assemblies is presented in this article. Based on the Trigonometric Shear Deformation Theory (TSDT) and the use of Gram?Schmidt orthogonal polynomials as enrichment functions a finite macro element is developed. In the TSDT framework, shear stresses are vanished at the top and bottom surfaces of the plates and shear correction factors are no longer required. The Principle of Virtual Work is applied to derive the governing equations of motion. A special connectivity matrix is obtained; so that hierarchically enriched global stiffness matrix and mass matrix of general laminated plate structures are derived, allowing to study generally coplanar plate assemblies by combining two or more macro elements. This procedure gives a matrix-eigenvalue problem that can be solved with optimum efficiency. Results of free vibration analysis for symmetric laminated plates of different thickness ratios, geometrical planform shapes and boundary conditions are presented. The accuracy of the formulation is ensured by comparing some numerical examples with those available in the literature.","palabras_clave":"COMPOSITE PLATES|MACRO ELEMENT|FREE VIBRATION|TRIGONOMETRIC SHEAR DEFORMATION THEORY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":733,"idioma_id":4,"titulo":"Magnetic Barkhausen Noise and Magneto Acoustic Emission in stainless steel plates","resumen":"When a slowly variable magnetic field (&#61566; Hz) is applied through a yoke on a ferromagnetic material, discontinuous changes on the magnetic flow density are produced. This phenomenon, called Magnetic Barkhausen Noise (MBN), obeys the movement of magnetic domain walls and its frequency range is about [10-100] kHz. It involves sudden magnetization changes and localized variations of mechanical stresses which originate elastic waves known as Magneto Acoustic Emission (MAE) on the frequency range of 20 kHz up to 1 MHz. Both, MBN and MAE depend on the material microstructural characteristics and they may be considered as non-destructive evaluation techniques. This work is based on MBN and MAE tests carried out on 5 groups of different stainless steel specimens (AISI 409, AISI 430, AISI 439, AISI 441A and AISI 444), for two applied magnetic fields, parallel and perpendicular to the rolling direction.","palabras_clave":"Barkhausen Noise|Magneto Acoustic Emission|stainless steel"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":734,"idioma_id":5,"titulo":"Revolución y escritura: Blanca Luz Brum en las dos orillas del Plata durante 1933","resumen":"Blanca Luz Brum, la poetisa uruguaya es recordada por su belleza y sus relaciones sentimentales con David Alfaro Siqueiros, Natalio Botana, Pablo Neruda y el mismo Juan Domingo Perón. No obstante esto, se trata de una escritora que tuvo una comprometida militancia de izquierda durante buena parte de su vida. Con el fin de obtener una imagen de Blanca Luz que le de al personaje una voz propia, como la que tuvo en su momento, el propósito de este texto es indagar acerca del período en el que estuvo en Buenos Aires junto con Siqueiros durante 1933. Para ello, revisaremos lo que se ha escrito sobre ella hasta el momento y cómo se la ha presentado y luego indagaremos sobre algunas repercusiones de su estadía en el Río de la Plata durante el año señalado y los textos que publicó durante ese período.&nbsp;","palabras_clave":"BLANCA LUZ BRUM|ESCRITORA|1933|POLÍTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":735,"idioma_id":5,"titulo":"Tecnologías de la información y las comunicaciones en educación: logros actuales y proyección hacia el futuro","resumen":"La aparición de los recursos digitales, en particular Internet, generó desde el principio la creación de nuevos modos de aproximarse al conocimiento, muchos de ellos nacidos espontáneamente de los usuarios. Este trabajo busca pasar revista a una selección de estos avances que creemos representativa de la orientación general del empleo de las TIC en educación. Además, presentamos un breve panorama de la situación actual del aprendizaje y empleo de estos conocimientos en América Latina, incluyendo lo hecho hasta ahora a través de las políticas de estado y el grado de conocimiento de estas herramientas que reflejan algunas encuestas recientes. Se analizaron también los desarrollos y posibilidades futuros, y el trabajo que resta por hacer en nuestra región. Se concluyó que se han hecho avances importantes que deben extenderse a todos los sectores de la sociedad, y que parte de esta tarea queda todavía por hacerse.    Palabras clave: formación docente, inclusión, políticas de estado, tecnologías del aprendizaje y el conocimiento","palabras_clave":"FORMACIÓN DOCENTE|INCLUSIÓN|POLÍTICAS DE ESTADO|TECNOLOGÍAS DEL APRENDIZAJE Y EL CONOCIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":737,"idioma_id":4,"titulo":"Kinetic characterization, optimum conditions for catalysis and substrate preference of secretory phospholipase A2 from Glycine max in model membrane systems","resumen":"Two secretory phospholipase A2 (sPLA2s) from Glycine max, GmsPLA2-IXA-1   and GmsPLA2-XIB-2, have been purified as recombinant proteins and the   activity was evaluated in order to obtain the optimum conditions for   catalysis using mixed micelles and lipid monolayers as substrate. Both   sPLA2s showed a maximum enzyme activity at pH 7 and a requirement of   Ca(2+) in the micromolar range. These parameters were similar to those   found for animal sPLA2s but a surprising optimum temperature for   catalysis at 60 °C was observed. The effect of negative interfacial   charges on the hydrolysis of organized substrates was evaluated through   initial rate measurements using short chain phospholipids with different   head groups. The enzymes showed subtle differences in the specificity   for phospholipids with different head groups (DLPC, DLPG, DLPE, DLPA) in   presence or absence of NaCl. Both recombinant enzymes showed lower   activity toward anionic phospholipids and a preference for the   zwitterionic ones. The values of the apparent kinetic parameters (Vmax   and KM) demonstrated that these enzymes have more affinity for   phosphatidylcholine compared with phosphatidylglycerol, in contrast with   the results observed for pancreatic sPLA2. A hopping mode of catalysis   was proposed for the action of these sPLA2 on mixed phospholipid\/triton   micelles. On the other hand, Langmuir-monolayers assays indicated an   optimum lateral surface pressure for activity in between 13 and 16 mN\/m   for both recombinant enzyme","palabras_clave":"phospholipase A2|glycine max|lipid monolayers|interfacial catalysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":738,"idioma_id":4,"titulo":"An Early Permian brachiopod-gastropod fauna from the Calytrix Formation, Barbwire Terrace, Canning Basin, Western Australia","resumen":"A small brachiopod-gastropod fauna from a core close tothe base of the Calytrix Formation within the Grant Group includes the brachiopods Altiplecus decipiens (Hosking), Myodelthyriumdickinsi (Thomas), Brachythyrinella narsarhensis (Reed), Neochonetes (Sommeriella) obrieni Archbold, Tivertonia sp. nov.? and the gastropod Peruvispira canningensis sp. nov. The fauna shows affinities with that of the late Sakmarian&#8210;early Artinskian Nura Nura Member directly overlying the group in other parts of the basin but, as with all Lower Cisuralian (and Upper Carboniferous) glacial strata in Western Australia, its precise age remains poorly constrained especially in terms of correlation to international stages. Although the Calytrix fauna lies within the Pseudoreticulatispora confluens palynozone, the only real age constraint on its age (and that of the associated glacially influenced strata) is from stratigraphically younger faunas. A brief review of radiometric ages from equivalent strata elsewhere in Gondwana shows that those ages need to be updated. The presence of Asselian strata and the position of the Carboniferous&#8210;Permian boundary remain unclear in Western Australia.","palabras_clave":"Permian |Calytrix Formation|Canning Basin|Fauna"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":740,"idioma_id":5,"titulo":"TRATAMIENTO PARA DATOS FALTANTES EN SERIES DE RADIACION SOLAR","resumen":"Para poder realizar un aprovechamiento racional de la energía solar es indispensable tener un  conocimiento apropiado de la distribución espacio-temporal del recurso a nivel de la superficie terrestre. Por ello el Grupo de Energía Solar de la Universidad Nacional de Río Cuarto, está realizando mediciones de radiación global y directa En la toma de datos existen muchas posibilidades decometer error de diferentes tipos, pero la más significativa es la falta de datos. Lo que se debe tener en claro es que hacer ante la falta de datos.   Ningún software realiza un tratamiento adecuado de los datos faltantes, están los que remplazan los datos faltantes por valores promedios en determinados intervalos prefijados, o los que simplemente eliminan en las estructura de los datos aquellos espacios en donde no se tiene la información. Por ello en esta ocasión la propuesta de trabajo fue la de remplazar los datos faltantes por valores inferidos de las series de datos precedentes. La metodología utilizada es la de los modelos estructurales de series de tiempo, dado que es interesante cuando la serie tiene datos faltantes. El tratamiento estadístico de los modelos estructurales de series de tiempo está basado en la forma de espacio de estado, el filtro de Kalman y el suaviazador asociado. La función de verosimilitud se construye a partir del filtro de Kalman en términos de la predicción un paso hacia adelante, y se maximiza con respecto a los hiperparámetros por optimización numérica. Una vez que los hiperparámetros fueron estimados, el filtro se usa para conseguir predicciones de los residuos un paso adelante, lo que nos permite calcular los estadísticos para probar normalidad, correlación serial y bondad deajuste, de esta manera el filtro analiza el sistema cada vez que hay una predicción pudiendo repetirse el proceso paso a paso.","palabras_clave":"radiación solar|tratamiento de datos|series de tiempo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":742,"idioma_id":4,"titulo":"Competition between grass-cutting Atta vollenweideri ants (Hymenoptera: Formicidae) and domestic cattle (Artiodactyla: Bovidae) in Argentine rangelands","resumen":"      Leafcutter ants are considered the most important herbivores in the Neotropics. Atta vollenweideri is a rangeland pest that competes with cattle for grass, reducing the carrying capacity of pastures.  However,   there is much controversy regarding their degree of herbivory, pest   status and competition with cattle. Furthermore, their economic injury   level (EIL) has not been determined.  We studied A. vollenweideri   in competition with cattle in a natural pasture in Argentina,   quantifying primary productivity, as well as herbivory by ants alone and   together with cattle. Productivity and herbivory by ants were   contrasted with cattle dietary requirements under two grazing regimes.   We estimated the first EIL for leaf-cutting ants in rangelands.  Productivity   was highly variable throughout the seasons. Competition between ants   and cattle was evident during the low productivity periods, with   evidence of ants being more affected by cattle unless ants store food   during the productivity peak in summer and autumn.  The EIL was   0.29 ant nests per hectare, although it likely overestimates the   importance of these ants as pests. We discuss the shortcomings of a   classic EIL formula for estimating the damage potential of social   insects.","palabras_clave":"cows|economic injury level|grass-cutting ants|herbivory|natural pastures"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":743,"idioma_id":4,"titulo":"Effect of phorid fly density on the foraging of Atta vollenweideri leafcutter ants in the field","resumen":"Leafcutter ants in the genus Atta (Hymenoptera: Formicidae:   Attini) are considered major pests of agriculture and forestry in the   Neotropics. Phorid flies (Diptera: Phoridae) have been proposed as   viable candidates for biological control of ants because of the   importance of their trait-mediated effects on their hosts. However, the   impact of different densities of phorid flies has never been assessed in   the field. Experiments were conducted by isolating 3-m sections of Atta vollenweideri Forel foraging trails with tunnels, and sampling ants in trails with 0, 1, or 4 Eibesfeldtphora trilobata Disney   female parasitoid flies. Samples were collected every 30&nbsp;min from these   trails. We also collected a sample before introducing the parasitoids   and another one 30&nbsp;min after removing them from the trail. We measured   traffic of ants on the trails, weight and type of plant material   transported, and the proportion and size of the workers collected. The   presence of phorids on the trails reduced the ant traffic and amount of   plant material transported into the nests and decreased the proportion   of workers on the trails in the size range preferred as hosts by the   flies. The effect on worker size, as well as the lag effect recorded   after phorids were removed from the tunnels, was more pronounced with   four phorids. The presence of phorids also affected the weight of   monocotyledon and dicotyledon material transported. Even at the minimum   density possible, phorids significantly influenced a key aspect of the   colony life, the food intake through foraging. From an applied point of   view, our results show that releases of these phorids into the field   should not necessarily involve many individuals to reduce foraging by A.&nbsp;vollenweideri, making them potentially useful candidates for biological control of these ants.","palabras_clave":"parasitoids|Eibesfeldtphora trilobata|leafcutter ants|biological control|Diptera|Phoridae|Hymenoptera|Formicidae"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":746,"idioma_id":5,"titulo":"REVALORIZACION DEL SISTEMA DE ESPACIOS ABIERTOS COMO CONTENCION DE LA EXPANSION URBANA. Los casos de Munich y Medellin","resumen":"PENDIENTE","palabras_clave":"ESPACIOS ABIERTOS|INSTRUMENTOS|CONTENCION|EXPANSION URBANA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":751,"idioma_id":5,"titulo":"PARÁMETROS AMBIENTALES Y PESQUEROS DE UN LAGO SOMERO DE LA PAMPA, LUEGO DE UNA MORTANDAD MASIVA DE Odontesthes bonariensis","resumen":"The Bajo Giuliani Lagoon (36 ° 42 ?20?? S, 64 ° 16 ? 02 ?? W) is located south of the city of Santa Rosa, La Pampa, which was stocked with fish during the late 90?s. In this hypertrophic shallow lake, major environmental changes caused mass mortalities of silverside Odontesthes bonariensis, the last one occurred in 2010. In order to know the current state of the environment, in April 2013 surface water samples were collected, several points were georeferenced and major morphometric parameters were estimated. Fish were captured by trawls and gillnets. The lake has an area of 965 ha with an average depth of 2.31 meters, hyposaline, hard and sodium chlorinated water. Captured register 549 specimens of O. bonariensis and 437 of Jenynsia multidentata, showing a low diversity. The captured silverside ranged from 75 to 343 mm standard length and from 4 to 568 grams. The catch per unit effort in number and biomass was 519 fishes\/ night and 99.2 kilos \/ night respectively, and the trophy size (PSD) was 41.6 6 %. The results indicate that PSD was 16% lower than those recorded before mortality in October 2009. Also, CPUE in number and CPUE in weight obtained were lower than that date. Nevertheless, several index showed better current body conditions.","palabras_clave":"LAGUNAS|LA PAMPA|ODONTESTHES BONARIENSIS|MORTANDAD PECES|ÍNDICES DE CONDICIÓN CORPORAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":753,"idioma_id":4,"titulo":"Mathematical programming as a tool for virtual soccer coaches: A case study of a fantasy sport game","resumen":"General awareness of the potential of mathematics to support sportsdecision-making has been raised by the movie Moneyball' through itsportrayal of a real professional American baseball club that used math-ematical tools to improve team performance. This article addresses thesame challenge, using as a test case a fantasy sport game organized byan Argentinian newspaper. Two mathematical programming models arepresented that act as virtual coaches which choose a virtual team lineupfor each round of the real Argentinian soccer league. The a priori designcreates a competitive team for the game while the a posteriori model deter-mines what would have been its optimal lineup once the season is over andall the results are known. The a priori model was entered in the fantasygame, achieving results that positioned it among the highest-scoring par-ticipants. Further development of such models would provide useful toolsfor supporting decision-making by coaches or managers of real sports.","palabras_clave":"fantasy game|integer programming"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":754,"idioma_id":4,"titulo":"Acid-induced Aggregation and Gelation of Sodium Caseinate-Guar Gum Mixtures","resumen":"The aim of this work was to study the formation of bovine sodium caseinate (NaCAS) acid gels induced by addition of glucono-&#948;-lactone (GDL) in the presence of guar gum (GG). At low biopolymer?s concentrations, a one-phase system was observed, whereas at higher mixture concentrations two-phase systems were formed. Aggregation (at low NaCAS concentrations) and gelation (at high NaCAS concentrations) processes were analyzed through the use of full and fractional factorial experiment designs, using turbidimetric and rheological techniques. Finally, the gel images were obtained by confocal laser scanning microscopy and the images were analyzed. Results showed that at low NaCAS concentrations, the presence of GG affects the pH at which aggregation begins but was not significant for the time at which aggregation begins. On the other hand, at high NaCAS concentrations, the concentration of GG only affected significantly the elastic character of acid gels. As polysaccharide concentration increases, the gels obtained were weaker and with larger pores. Also, the formation of NaCAS droplet-shaped structures at certain biopolymer ratio was observed. The presence of GG affects both the rate of gelation andphase separation, which, in turn, determine the type of gel microstructure. Phase separationseems to occur prior to protein gelation because the protein gel network is discontinued,hindering the gel compactness and reducing gel strength. In summary, GG modifies NaCAS stabilization (self-association and phase separation) and the viscoelasticity and microstructure of NaCAS acid gels. The control of such processes and properties wouldallow obtaining mixture gels with different textures.","palabras_clave":"SODIUM CASEINATE\/GUAR GUM ACID GELS|THERMODYNAMIC INCOMPATIBILITY|RHEOLOGICAL PROPERTIES|MICROSTRUCTURE|EXPERIMENT DESIGN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":755,"idioma_id":5,"titulo":"La trepanación vertebral como un método alternativo para la inoculación intraparenquimatosa de diversas suspensiones dentro de la médula espinal","resumen":"Rutinariamente, la administración de fármacos u otras sustancias químicas en regiones específicas de la médula espinal se realiza mediante diferentes técnicas de abordaje, siendo la laminectomía una de las más utilizadas. El objetivo del presente trabajo fue evaluar una técnica de trepanación como una forma alternativa para la descarga de diversas suspensiones en los segmentos cervicales (C) de la médula espinal. Para ello, se utilizaron ratas Sprague-Dawley macho. Previo a la trepanación, los músculos de la región cervical fueron divulsionados. Una vez localizados los arcos de las vértebras C4 y C5, se practicó la trepanación del disco intervertebral utilizando una fresa dental montada sobre un taladro rotatorio. El orificio practicado sirvió como punto de introducción de una aguja para la descarga de solución salina. Esta solución fue descargada en la hemimédula derecha del segmento C5. Las ratas se sacrificaron a las 24 h post inoculación (p.i.). La médula espinal extraída, y los segmentos cervicales fueron procesados para el análisis histopatológico y el recuento de neuronas. Los animales no mostraron alteraciones estructurales en ninguna de las hemimédulas, excepto en el sitio de ingreso de la aguja. La técnica de la trepanación aquí descrita es precisa, relativamente rápida y de fácil ejecución. La misma puede ser utilizada como un método alternativo a la laminectomía, para la inoculación y distribución de medicamentos, factores de crecimiento u otras suspensiones a ser inoculadas en la médula espinal.","palabras_clave":"MÉDULA ESPINAL CERVICAL|TREPANACIÓN|INOCULACIÓN INTRAPARENQUIMAL|RECUENTO|ANÁLISIS DE IMÁGENES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":756,"idioma_id":4,"titulo":"Evaluation of dihydroquercetin-3-O-glucoside from Malbec grapes as copigment of malvidin-3-O-glucoside","resumen":"Malbec is a wine grape variety of great phenolic potential characterized for its high levels of anthocyanins and dihydroflavonols. To evaluate the possible implication of dihydroflavonols in the expression of red wine color through reactions of copigmentation or condensation, assays were carried out in wine model systems with different malvidin-3-O- glucoside:dihydroquercetin-3-O-glucoside molar ratios. The addition of increasing levels of dihydroquercetin-3-O-glucoside to a constant malvidin-3-O-glucoside concentration resulted in a hyperchromic effect associated with a darkening of the anthocyanin solutions, greater quantity of color and visual saturation, perceptible to the human eye. Copigmentation and thermodynamic measurements showed that dihydroquercetin-3-O-glucoside can act as an anthocyanin copigment, similar to other usual wine components like flavanols or phenolic acids, although apparently less efficient than flavonols. The high levels of dihydroflavonols existing in Malbec wines in relation to other non-anthocyanin phenolics should make this family of compounds particularly important to explain the color expression in Malbec young red wines.","palabras_clave":"copigmentation|dihydroflavonols|anthocyanins|color|Malbec"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":757,"idioma_id":4,"titulo":"Effects of spike-triggered negative feedback on receptive-field properties","resumen":"Sensory neurons are often described in terms of a receptive field, that is, a linear kernel through which stimuli are filtered before they are further processed. If information transmission is assumed to proceed in a feedforward cascade, the receptive field may be interpreted as the external stimulus´ profile maximizing neuronal output. The nervous system, however, contains many feedback loops, and sensory neurons filter more currents than the ones representing the transduced external stimulus. Some of the additional currents are generated by the output activity of the neuron itself, and therefore constitute feedback signals. By means of a time-frequency analysis of the input\/output transformation, here we show how feedback modifies the receptive field. The model is applicable to various types of feedback processes, from spike-triggered intrinsic conductances to inhibitory synaptic inputs from nearby neurons. We distinguish between the intrinsic receptive field (filtering all input currents) and the effective receptive field (filtering only external stimuli). Whereas the intrinsic receptive field summarizes the biophysical properties of the neuron associated to subthreshold integration and spike generation, only the effective receptive field can be interpreted as the external stimulus´ profile maximizing neuronal output. We demonstrate that spike-triggered feedback shifts low-pass filtering towards band-pass processing, transforming integrator neurons into resonators. For strong feedback, a sharp resonance in the spectral neuronal selectivity may appear. Our results provide a unified framework to interpret a collection of previous experimental studies where specific feedback mechanisms were shown to modify the filtering properties of neurons.","palabras_clave":"Receptive field|Adaptation|Feedback|Resonance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":758,"idioma_id":4,"titulo":"New rodents (Mammalia) from the late Oligocene of Cabeza Blanca (Chubut) and the first rodent radiation in Patagonia","resumen":"Caviomorph rodents, the New World Hystricognathi, are one of the most characteristic groups of South American mammals. Although they have been in the continent at least since the middle Eocene, those of the Deseadan Land mammal Age (early?late Oligocene) are the best source to understanding their early history due of their good record, large geographic distribution and good temporal calibration of many of the local faunas. Here, we describe the following new taxa from the classical locality of Cabeza Blanca: Octodontoidea Acaremyidae Galileomys baios n. sp., Octodontoidea incertae sedis Ethelomys loomisi n. gen., n. comb., Acarechimys leucotheae n. sp., Protacaremys? adilos n. sp.,Chinchilloidea  incertae sedis Loncolicu tretos n. gen., n. sp., Incamys menniorum n. sp., Caviomorpha incertae sedis Llitun notuca n. gen., n. sp., Leucokephalos zeffiae n. gen., n. sp. and Cephalomyidae Cephalomys ceciae n. sp. The DP4 of an ?eocardiid?,Asteromys punctus? is described for the first time. These new taxa allow us to reinterpret the relationships of some of the previously known Deseadan species and genera. They show a great early diversification at least for extra Andean Patagonia, involving at least three of the main caviomorph lineages: octodontoids, chinchilloids and cavioids.","palabras_clave":"CAVIOMORPHA|TAXONOMY|SOUTH AMERICA|DESEADAN SALMA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":759,"idioma_id":4,"titulo":"Tool production processes in lithic quarries from the Central Plateau of Santa Cruz, Argentina.","resumen":"Lithic resources at the Central Plateau of Santa Cruz (Argentina) are abundant, ubiquitous and of a very good quality for knapping. They have been exploited by hunter-gatherer societies since the final Pleistocene until the Late Holocene. The study of their distribution, availability and ways of exploitation at the quarries, together with the information stemming from the archaeological sites, enable the understanding of the first stages of tool production and consumption.  In this paper, two quarries from La María Archaeological Locality (Cantera de Sílex de CDM and Cantera Bosque Petrificado) are studied and compared. Their geomorphological localization is described. The lithological characteristics of the outcrops, the size of the stones and the variability of raw materials available at them are also addressed. The accessibility and visibility of the quarries are analyzed. The way raw materials were exploited at the sources is evaluated taking into consideration their relationship with the local and regional structure of lithic resources. The information generated for the quarries is complemented and compared with the local trends identified for the habitation sites. This enabled the formulation of a general model about the first stages of production.  Although the quarries have different types of raw materials (flint and silicified wood), results show that similar technological strategies were implemented in them. These are in agreement with the general trend at the local and regional levels. Both sources are easily accessible from the surrounding landscape. They are visible from nearby areas. Probably, they were exploited mainly from close by sites. At the quarries the first stages of tool production were performed: core decortication and preparation and the production of blanks. The acquisition of raw material involved the selection of good quality nodules and boulders and the production of polyhedral cores knapped in multiple directions. These cores could be transported to the habitation sites or could be discarded in situ while still presenting active platforms. On the other hand, differences in some procurement practices might be related to decisions and variations linked to the particular characteristics of the resources in both outcrops.","palabras_clave":"Raw material sources |In situ classi&#64257;cation |Procurement strategies |Tool production"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":762,"idioma_id":4,"titulo":"New records and geographic distribution map of Echinoporia Ryvarden (Schizoporaceae, Basidiomycota) species in the Neotropics","resumen":"The genus Echinoporia is characterized by the presence of chlamydospores originating from hairs in the pileus and margin, or the dissepiments edges. Two species of Echinoporia are found in American, i.e., E. aculeifera and E. inermis. In the frame of thea study of Neotropical polypores, several specimens of Echinoporia were collected in the Atlantic rainforest, São Paulo state. Echinoporia inermis is recorded by for the second time in Brazil. Echinoporia aculeifera is recorded for the first time in São Paulo state. A distribution map of the genus in the Neotropics is presented.","palabras_clave":"Neotropical polypores"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":763,"idioma_id":4,"titulo":"Description of the tadpole of Alsodes neuquensis Cei, 1976 and comparison with the sibling species A. gargola Gallardo, 1970.","resumen":"This paper describes the external and buccopharyngeal morphology, chondrocranium, and cranial muscles of Alsodes neuquensis in direct comparison with the sibling species A. gargola. The tadpole of A. neuquensis presents a shorter and higher tail, and a relatively smaller oral disc than A. gargola. The external larval morphology of Alsodes may be characterized as follows: (1) tooth row formula 2(2)\/3(1); (2) single row of marginal papillae with a wide rostral gap; (3) single row of intramarginal papillae in the mental region; and (4) both supra- and infraangular intramarginal papillae present. The buccal features do not show great intrageneric differences; the anterior and\/or posterior pair of infralabial papillae may be simple or forked, all known tadpoles present one prenarial papilla accompanied or not by few pustules, and the lateral ridges of floor can be three- to penta-armed. The chondrocranial features shared by the species of the genus Alsodes are: (1) tetrapartite cartilage suprarostralis; (2) chondrified adrostral tissue mass; (3) processus anterolateralis of the larval crista parotica well developed or larval processus oticus, and (4) large processus pseudopterygoideus that may be either completely fused to the basi cranii (A. vanzolinii, A. verrucosus, and some A. neuquensis) or fused only at the tip (A. barrioi, A. gargola, and some A. neuquensis). Larval cranial muscles are for the first time described for the genus Alsodes. They do not show differences between both species studied herein.","palabras_clave":"Buccal papillation|Cranial muscles|Chondrocranium|External morphology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":764,"idioma_id":4,"titulo":"Changes in resource-use strategy and phenotypic plasticity associated with selection for yield in wild species native to arid environments","resumen":"Along   history, wild plants have been introduced into cultivation and domestic   derivatives radically altered by this move due to changes in selection   pressure: wild species are exposed to natural selection that operates to   continue survival and domesticated species to artificial selection that   emphasized yield. Here we assess whether selection for yield triggered a   shift in resource-use strategy and changes in phenotypic plasticity. We   compared co-generic wild and domesticated species grown in a common   garden under two levels of water availabilities. Our results indicate   that resource-use strategy shifted from conservative to acquisitive. The   change in selection force from survival to reproduction provoked an   increase in mean values of reproduction-related traits and a decrease in   survival-related traits. Trade-offs between reproduction and storage   were found in both groups. This occurred concurrently with an increase   in phenotypic plasticity of most traits. Wild species showed higher   homeostasis than domesticated species. Despite the lesser homeostasis of   the latter, improvements in reproductive traits were not completely   reversible under low resource availability: across environments   domesticated species always showed higher reproductive biomass and   reproductive effort than their wild relatives. The combination of higher   mean values of advantageous traits and greater plasticity might   contribute to the success of domesticated species in plentiful   environments.      ","palabras_clave":"acquisitive|conservative|reproductive effort|tradeoffs"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":765,"idioma_id":5,"titulo":"Análisis de las comunidades liquénicas presentes en construcciones edilicias de la ciudad de La Plata","resumen":"Los líquenes son organismos capaces de crecer sobre una amplia variedad de superficies tanto naturalescomo artificiales, es el caso de los edificios y monumentos en las ciudades. En la provincia de BuenosAires a pesar de ser una de las provincias con mayor desarrollo urbano del país, el conocimiento de suliquenobiota es aún es escaso. La mayoría de los estudios se han realizado principalmente en ambientesnaturales, aunque hay algunos pocos registros de líquenes en ciudades. Se relevaron los líquenes enedificios de la ciudad de La Plata y mediante análisis multivariados (PCA) se analizó la composición y laestructuras de las comunidades presentes. Se encontraron tres especies comunes en todos los muestreos,y especies acompañantes con baja cobertura y apariciones esporádicas. F. austrocitrina es una especiedominante que ha mostrado ser capas de vivir en las ciudades y poder adaptarse a este tipo particular desustrato.","palabras_clave":"LÍQUENES|EDIFICIOS|PCA|COMUNIDADES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":766,"idioma_id":4,"titulo":"Mouse GDF9 decreases KITL gene expression in human granulosa cells.","resumen":"Kit ligand (KITL) is an important granulosa cell-derived growth factor   in ovarian folliculogenesis, but its expression and function in human   granulosa cells are currently poorly understood. Based on studies   performed in animal models, it was hypothesised that KITL gene   expression in human granulosa cells is regulated by androgens and\/or   growth differentiation factor 9 (GDF9). We utilised two models of human   granulosa cells, the KGN granulosa tumour cell line and cumulus   granulosa cells obtained from preovulatory follicles of women undergoing   assisted reproduction. Cells were treated with combinations of   5&#945;-dihydrotestosterone (DHT), recombinant mouse GDF9, and the ALK4\/5\/7   inhibitor SB431542. KITL mRNA levels were measured by quantitative   real-time PCR. No change in KITL mRNA expression was observed after DHT   treatment under any experimental conditions, but GDF9 treatment resulted   in a significant decrease in KITL mRNA levels in both KGN and cumulus   cells. The effect of GDF9 was abolished by the addition of SB431542.   These results indicate that KITL is not directly regulated by androgen   signalling in human granulosa cells. Moreover, this study provides the   first evidence that GDF9 negatively regulates KITL gene expression in   human granulosa cells providing new information on the regulation of   these important growth factors in the human ovary.","palabras_clave":"GRANULOSA CELLS|OVARY|C-KIT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":767,"idioma_id":4,"titulo":"Effects of stratospheric ozone depletion, solar UV radiation and climate change on biogeochemical cycling: interactions and feedbacks","resumen":"Climate change modulates the effects of solar UV radiation on biogeochemical cycles in terrestrial and aquatic ecosystems, particularly for carbon cycling, resulting in UV-mediated positive or negative feedbacks on climate. Possible positive feedbacks discussed in this assessment include: (i) enhanced UV-induced mineralisation of above ground litter due to aridification; (ii) enhanced UV-induced mineralisation of photoreactive dissolved organic matter (DOM) in aquatic ecosystems due to changes in continental runoff and ice melting; (iii) reduced efficiency of the biological pump due to UV-induced bleaching of coloured dissolved organic matter (CDOM) in stratified aquatic ecosystems, where CDOM protects phytoplankton from the damaging solar UV-B radiation. Mineralisation of organic matter results in the production and release of CO2, whereas the biological pump is the main biological process for CO2 removal by aquatic ecosystems. This paper also assesses the interactive effects of solar UV radiation and climate change on the biogeochemical cycling of aerosols and trace gases other than CO2, as well as of chemical and biological contaminants. Interacting effects of solar UV radiation and climate change on biogeochemical cycles are particularly pronounced at terrestrial-aquatic interfaces.","palabras_clave":"ULTRAVIOLET RADIATION|BIOGEOCHEMICAL CYCLES|CARBON CYCLING|REVIEW"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":768,"idioma_id":4,"titulo":"High levels of Trypanosoma cruzi DNA detemined by qPCR and infectiousness to Triatoma infestans support dogs and cats are major sources of parasites for domestic transmission","resumen":"The competence of reservoir hosts of vector-borne pathogens is directly linked to its capacity to infect thevector. Domestic dogs and cats are major domestic reservoir hosts of Trypanosoma cruzi, and exhibit amuch higher infectiousness to triatomines than seropositive humans. We quantified the concentrationof T. cruzi DNA in the peripheral blood of naturally-infected dogs and cats (a surrogate of intensity of parasitemia),and evaluated its association with infectiousness to the vector in a high-risk area of the ArgentineanChaco. To measure infectiousness, 44 infected dogs and 15 infected cats were each exposed toxenodiagnosis with 10?20 uninfected, laboratory-reared Triatoma infestans that blood-fed to repletionand were later individually examined for infection by optical microscopy. Parasite DNA concentration(expressed as equivalent amounts of parasite DNA per mL, Pe\/mL) was estimated by real-time PCR amplificationof the nuclear satellite DNA. Infectiousness increased steeply with parasite DNA concentrationboth in dogs and cats. Neither the median parasite load nor the mean infectiousness differed significantlybetween dogs (8.1 Pe\/mL and 48%) and cats (9.7 Pe\/mL and 44%), respectively. The infectiousness of dogswas positively and significantly associated with parasite load and an index of the host?s body condition,but not with dog?s age, parasite discrete typing unit and exposure to infected bugs in a random-effectsmultiple logistic regression model. Real-time PCR was more sensitive and less time-consuming thanxenodiagnosis, and in conjunction with the body condition index, may be used to identify highly infectioushosts and implement novel control strategies.","palabras_clave":"Triatoma infestans|infecciosidad de Trypanosoma cruzi|perros gatos|cuantificacion parasitaria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":769,"idioma_id":5,"titulo":"Violencia y represión en el humor gráfico: Chaupinela y HUMOR (1974-1980)","resumen":"En este artículo nos proponemos analizar las representaciones humorísticas de la violencia política y la represión publicadas Chaupinela (1974-1975) y HUM® (1978-1980), las revistas satíricas porteñas editadas por Andrés Cascioli. El objetivo es definir continuidades y rupturas en relación al Golpe de Estado a los fines de establecer cómo y en qué medida esos medios de prensa delimitaron los contornos del campo de lo decible y lo visible en torno a la violencia política imperante.","palabras_clave":"DICTADURA MILITAR|TERRORISMO DE ESTADO|HUMOR GRÁFICO|REVISTA HUMOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":770,"idioma_id":5,"titulo":"De las formas históricas de existencia de la individualidad a la forma sujeto del discurso: Marx, Althusser, Pêcheux","resumen":"El pensamiento de Michel Pêcheux, está jalonado por varias autocríticas que modulan etapas en su pensamiento (ver Maldidier 2003, Gregolin 2007, Hernández y Terriles 2014) Se trata de etapas donde los nuevos trabajos parecen dejar atrás los desarrollos previos. Sin embargo este pensamiento conserva, paradójicamente, casi en cualquiera de los estadios de su recorrido que se quiera considerar, una extraña pujanza. Lo que queremos decir es que sus textos tempranos, por ejemplo aquellos de la década de 1960, pueden leerse aún hoy como textos inquietantes, llenos de sugerencias, contrariando la opinión que su autor se hizo de ellos, quien muchas veces creyó dejarlos atrás como superados, por hallarlos plagados de errores. El hecho podría recibir explicaciones diversas. Podemos pensar, naturalmente, que las distintas coyunturas en las que su pensamiento se insertó hicieron de sus posiciones teóricas agudas respuestas a la coyuntura, pero que sin embargo, en la medida en que son escritura, sus posiciones son algo más que eso, desbordando su contexto de emergencia, un fenómeno que también puede apreciarse a propósito de Althusser, quien, precisamente en virtud de estudios que lo restituyen en su coyuntura política y teórica,  filosófica y científica (ver Elliot 2006 y Montag 2013 y Cavazzini 2011), estudios que de un modo u otro salen al encuentro del ?Althusser histórico? y que hacen emerger un Althusser de una enorme relevancia para las preguntas más candentes que se le plantean hoy las praxis política y teórica. Pierre Macherey ha sugerido que Pêcheux se asemejó como nadie a Althusser en lo que tal vez fue su característica más temible: una vocación autodestructiva, un impulso teórico audaz que llevó, a ambos, a destruir constantemente su propio trabajo anterior, como si ello fuera un recurso necesario para hacer lugar para su trabajo venidero (Macherey 2014). No parece aventurado ver en este rasgo una consecuencia de entender a la teoría como un conjunto de opciones teóricas abigarradas, de opciones teórico-filosóficas que cubren todo el espacio, de manera que para hacer lugar a posiciones nuevas, para poder responder a una coyuntura transformada, teórica y políticamente, se les imponía como una condición absoluta, tanto a Pêcheux como a su maestro, la destrucción de lo construido con anterioridad (ver Macherey 2014, ver también Balibar 2004).   \tLa distancia entre la coyuntura teórica en la que desarrolló su trabajo Pêcheux y la nuestra es a primera vista de una magnitud insalvable. El elemento que marca de la diferencia entre aquellos años sesenta, la década del setenta, e incluso la de los ochenta, es la fuerte presencia del marxismo tanto en la escena teórica como en la política nacional e internacional. Desde entonces esta presencia se ha desvanecido. No nos concentraremos en el hecho de que este desvanecimiento remite, en muchos casos, en Latinoamérica en particular, a la desaparición de los cuerpos que sostenían esas posiciones (ver por ejemplo Marín: 1987). Sin embargo, esta distancia abismal es también la clave de la vitalidad del pensamiento de Pêcheux. Para decirlo de un modo esquemático: el espacio dejado por el marxismo no ha quedado vacío, sino que ha sido llenado con ciertas formas de teoría que sintonizan muy bien con lo que el grupo entero de los althusserianos entendían que era la forma de teoría que funciona como ideología teórica dominante de las ideologías prácticas que se entrelazan con las relaciones de producción del modo de producción capitalista: el humanismo. Estas ideologías se articulan bajo la dominación de las relaciones jurídicas en las que se realiza este modo de producción, cuyos principios dividen el universo en dos clases de entidades: personas y cosas, a partir de las cuales pueden definirse dos clases de relaciones, relaciones de persona a persona, es decir ?contratos? y relaciones de persona a cosa, es decir ?relaciones de propiedad?. Estas dos relaciones, según está representadas en la ideología jurídica, son contingentes en relación al ser mismo de las entidades básicas, puesto que los contratos son resultado de la libre voluntad de los contratantes, lo que deja, en el límite, la posibilidad de no entablar ningún contrato. En cuanto a las relaciones de propiedad, las cosas, si bien están sometidas al arbitrio de sus poseedores, que pueden hacer de ellas el uso que mejor les convenga, para poder estar sometidas a esta libre disponibilidad no deben imponer ninguna constricción a sus poseedores. En el límite el paradigma de la propiedad de la ideología jurídica es el atesoramiento, la posesión ociosa de un bien. Lo que queremos destacar de esta concepción ideológica jurídica es que las entidades básicas de la misma, personas y cosas como dijimos, están dotadas de una existencia independiente, de modo que las relaciones de contrato o de propiedad pueden o no entablarse sin que esto las afecte en su existencia. Si fuéramos a decirlo con la jerga de la metafísica tradicional, deberíamos decir que para esta ideología personas y cosas son sustanciales, mientras que las relaciones son accidentales.  \tAhora bien, en la filosofía universitaria hemos visto, en los últimos 25 años, renacer una serie de opciones teóricas que se subordinan a la dominante de la ideología jurídica por el flanco del individualismo: el renacimiento del mentalismo y la primacía de la ética y una de una filosofía política que la prolonga sin grandes rupturas, como disciplina filosóficas dominantes. Incluso en el pensamiento de izquierda se pueden reconocer los efectos de esta hegemonía. En el caso latinoamericano, bajo la feroz persecusión sufrida en los años setenta, acaeció una reconversión del discurso de la izquierda tradicional, cuya matriz era histórica y sociológica, a favor de un discurso en términos de derechos, esto es, un discurso de matriz jurídica (ver Markarian 2004). Que el discurso en términos de derechos sea la expresión política con la que los intentos neokeynesianos, neodesarrollistas o populistas latinoamericanos enfrentan la matriz del discurso neoliberal no es, acaso, más que un síntoma de la acendrada hegemonía del pensamiento liberal que el ocaso del marxismo ha dejado como herencia.   \tEn el pensamiento social asistimos a elaborados esfuerzos de presentar a la realidad social como producto de la aceptación colectiva.1 En línea con estas premisas, la realidad social es presentada como un fluido de decisiones individuales, de manera que cabría hablar de una suerte de democracia instantánea que se manifestaría en el zapping, el rating televisivo, las encuestas de opinión, etc. La profundidad de esta dominación puede medirse en el hecho de que la oposición a la misma es interior a su propia problemática, tendiendo a enfatizar el carácter fáctico de los acuerdos y los procesos de subjetivación, para lo que usualmente apela a un esquema bastante próximo al de la alienación, al verse obligada a postular un núcleo de racionalidad, seminal o por venir, que habría sido reprimida, es decir, desviada u obstaculizada, por factores ajenos a la misma, aunque  este núcleo persistiría siempre, como un telos al que puede apelarse para constituir una teoría critica.2   \tNo es nuestro propósito aquí hacer un diagnóstico detallado de la situación del pensamiento contemporáneo, sino simplemente evocar con trazos gruesos algunos rasgos de la coyuntura teórica contemporánea para obtener una respuesta orientadora para el sorprendente efecto ?de te fabula narratur? que producen los textos de Althusser y de Pêcheux: la coyuntura teórica con la que nos enfrentamos, siendo muy diferente en su letra, se asemeja mucho en sus presupuestos, en su problemática, a aquello que Althusser designó con el nombre de humanismo y que Pêcheux combatió de distintas maneras, en particular, al reencontrarlo entre los presupuestos de la semántica.","palabras_clave":"Individualidad|Modo de producción|Sujeto|Discurso|Ideología"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":771,"idioma_id":4,"titulo":"The cingulates (Mammalia: Xenarthra) from the late Quaternary of Northern Brazil: fossil records, paleoclimates and displacements in America","resumen":"            This paper presents the Quaternary cingulates collected from two  limestone caves in Aurora do Tocantins, northern Brazil. Osteoderms of Euphractus sexcinctus, Dasypus novemcinctus, Propraopus sulcatus, and Pachyarmaterium brasiliense were retrieved, representing an expansion on the known  distribution of the taxa. The specimens are described herein, and their  geographic and chronologic distributions are reviewed. Absolute datings allied to the presence of biostratigraphically  relevant taxa indicate a Late Pleistocene?middle Holocene age. Considering that  E. sexcinctus and D. novemcinctus occupy the area  nowadays, why part of the past cingulate community survived and the other part  went extinct? We believe that their distribution was affected by paleoclimatic  shifts, especially during glacial\/interglacial  cycles. The colder and arid climate of the Pleistocene glacial periods favored  the development of open forests and savannas in Brazil, whereas grasslands and  steppes were predominant in higher latitudes. Probably, Propraopus and Pachyarmatherium  (from the South and from the North, respectively) took refuge in lower  latitudes, including in Brazil. Later, during the interglacial cycle, warm and  moist climates favored the development of an evergreen forest in central  Brazil, leading Propraopus and Pachyarmatherium to extinction and  positively selecting E. sexcinctus and  D. novemcinctus.  ","palabras_clave":"Armadillos|Biogeography|Dasypodidae|Pleistocene"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":774,"idioma_id":4,"titulo":"Modulation of apoptosis in equine herpesvirus-1 infected cells.","resumen":"Se adjunta archivo","palabras_clave":"Herpsvirus equino 1|Apoptosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":775,"idioma_id":5,"titulo":"Iglesia Católica y activismo pro-vida. Discursos científico-religiosos e intervenciones público-colectivas en torno al aborto","resumen":"Las formas en que la Iglesia Católica interviene en los debates sobre aborto y salud sexual y reproductiva obliga a la necesidad de complejizar las perspectivas de análisis a fin de poder observar la capacidad que dicha institución tiene de afirmar su pensamiento y doctrina en la emergencia de nuevos actores, prácticas y discursos. El movimiento de laicos pro-vida se convirtió en uno de los fenómenos sociales y políticos más significantes del catolicismo de los últimos tiempos. El discurso político-opositor de los actores eclesiásticos y las prácticas socio-colectivas que los militantes pro-vida llevan a cabo en la esfera pública tienden a obstruir y a detractar el accionar de los colectivos feministas. El objetivo de este ensayo es analizar las transformaciones que desde el catolicismo se vienen haciendo del mensaje opositor al aborto y el modo en que los fundamentos basados en la religión intentan ser gravitantes a partir de su sinergia y complementariedad con un conjunto de elementos retóricos de orden secular. Esto es, la construcción de un discurso de defensa del 'derecho a  la vida por nacer' a partir del entrelazamiento entre argumentos religiosos y científicos-bioéticos. ","palabras_clave":"IGLESIA CATÓLICA|ABORTO|ACTIVISMO PRO-VIDA|BIOÉTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":777,"idioma_id":4,"titulo":": Asteroidal quadruples in non rooted path graphs","resumen":"A directed path graph is the intersection graph of a family of&nbsp; directed subpaths of a directed tree. A rooted path graph&nbsp; is the intersection graph of a family of directed subpaths of a&nbsp; rooted tree. Rooted path graphs are&nbsp; directed path graphs. Several characterizations are known for&nbsp; directed path graphs: one by forbidden induced subgraphs and one by&nbsp; forbidden asteroids.&nbsp; It is an open problem to find such&nbsp; characterizations for rooted path graphs. For this&nbsp; purpose, we are studying in this paper directed path graphs that are&nbsp;&nbsp; non rooted path graphs.&nbsp; We prove that such&nbsp; graphs always contain an asteroidal quadruple.","palabras_clave":"CHORDAL|ASTEROIDS|ROOTED"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":778,"idioma_id":5,"titulo":"La Universidad Nacional de La Plata entre 1973 y 1983","resumen":"En este trabajo analizaremos las principales políticas diseñadas e implementadas por el único rector (presidente) civil que tuvo la Universidad Nacional de La Plata [en adelante UNLP] entre 1976 y 1983, Guillermo Gallo, haciendo un breve repaso de los hechos más importantes ocurridos en los años previos (1973- 1976). Observaremos cómo durante el tercer gobierno peronista predominaron la inestabilidad y la violencia política, y de qué manera con la llegada de Gallo se profundizó la represión estatal. Asimismo, describiremos los argumentos que se esgrimieron para cerrar carreras e justificar las políticas de exclusión como el examen de ingreso, el cupo y la expulsión de miles de estudiantes, y lo ocurrido después de la sanción de la Ley Universitaria en 1980.","palabras_clave":"UNIVERSIDAD|LA PLATA|PERONISMO|DICTADURA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":779,"idioma_id":5,"titulo":"Erupciones históricas del volcán Tromen: análisis  geomorfológico y geocronológico en su sector noroeste","resumen":"Se estudiaron los productos más jóvenes del volcán Tromen en su sector NO. En base al análisis de reportes históricos en conjunto con datos geomorfológicos y una edad radiocarbono, se determinó que los últimos períodos de actividad del volcán Tromen son posteriores a 1400 d.C. Dos ciclos eruptivos constituidos por fenómenos de baja peligrosidad volcánica fueron registrados. El primero tuvo lugar entre los años 1400 y 1751 d.C. y el último entre 1820 y 1828 d.C. Los resultados obtenidos presentan relevancia para la evaluación del riesgo volcánico de las poblaciones cercanas.","palabras_clave":"MACIZO DEL TROMEN|ACTIVIDAD HISTORICA|GEOMORFOLOGIA|EDAD RADIOCARBONO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":781,"idioma_id":4,"titulo":"Parameters of synthesis of two fold materials for application in thermal compression and gross purification of hydrogen","resumen":"    The  development of materials for use in hydrogen technology is carried out within a  minimalist and ecologist purpose. In such a way, this work presents results  on the synthesis and characterization of materials for two different applications  related to the use of hydrogen in a clean technology scheme. The materials are  obtained by heat treatment of a mixture of intermetallics synthesized by medium  energy milling from a mixture of LaNi5 (70% m\/m), (La0.25Ce0.52Nd0.17Pr0.06)Ni5  (30% m\/m). Samples were characterized during the milling process by X-ray  diffraction (XRD) and scanning electron microscopy (SEM). Three stages of  milling were identified. Final mixture obtained was thermally treated in Ar  atmosphere at 600 ° C during 24 h for the potential application in thermal  compression of hydrogen. Similarly, the sample was thermally treated in air  at different temperatures for its potential application in hydrogen gross  purification.  ","palabras_clave":"Mechanical alloying|Hydrogen gross purification|Hydrogen thermal compression|XRD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":782,"idioma_id":4,"titulo":"A quantitative analysis of the hydrogen sorption isotherms of MmNi4.25Al0.75","resumen":"      The  development of materials for hydrogen thermal compression should follow  minimalistic and ecological aspects including low energy consumption, low-cost  unitary operation production and low waste generation. These concepts are  applied in this work by applying models previous to measurements in devices.  The results include the application of a quantitative model to measurements of  hydrogen sorption properties of an intermetallic of composition MmNi4,25Al0,75,  synthesized by low energy reactive milling.&nbsp;  The intermetallic was annealed in Ar at 600 ºC for 24 h to improve  the microstructural properties. The samples were analyzed in a Sievert?s-type  device. Curves of pressure vs. composition were previously obtained in a  temperature range between 25   ºC and 100   ºC. A modeling of PCT curves was done. Two different  stages were analyzed. The parameters involved in the model correspond to  thermodynamic properties DHf y DSf&nbsp; of hydride formation. These results are used  in the design of a one-stage hydrogen thermal compressor.  ","palabras_clave":"Thermal compression of hydrogen |PCT|modeling |quantitative analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":783,"idioma_id":5,"titulo":"Diversidad estructural y temporal de aracnidos epigeos (Arachnida), excepto acaros, en el sistema serrano de Tandilia (Buenos Aires, Argentina)","resumen":"Los arácnidos conforman un eslabón relevante en las cadenas de alimentación.  Las arañas, dada su gran abundancia, biomasa y diversidad, se encuentran directamente relacionadas con la diversidad ambiental. El estudio se llevó a cabo en la Reserva Natural ?Sierra del Tigre?, partido de Tandil, Buenos Aires, Argentina. El objetivo de este trabajo comprendió el análisis de aspectos ecológicos de una comunidad de arácnidos epigeos en dicha reserva. Se realizaron muestreos mensuales desde mayo de 2011 a mayo de 2012 utilizando trampas de caída. Se colectaron un total de 2626 arácnidos pertenecientes a cinco órdenes: Araneae, Scorpionida, Opiliones, Solifugae y Pseudoescorpiones, de los cuales el orden Araneae resultó el más abundante. Se encontraron diferencias significativas en cuanto a la estacionalidad y la abundancia. La curva de acumulación de especies del orden Araneae no llegó a una asíntota. Resulta de gran importancia conocer la composición de arácnidos en un área natural, la cual  pretende conservar el pastizal serrano. La diversidad de especies en esta área destaca el valor de la misma para la conservación de la biodiversidad.","palabras_clave":"ARAÑAS|ECOLOGIA|VARIACION ESTACIONAL|RESERVA NATURAL 'SIERRA DEL TIGRE'"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":786,"idioma_id":4,"titulo":"Isolation and characterization of Sacchamoryces species for bioethanol production from  sugarcane molasses: studies of scale up in bioreactor","resumen":"Decreases in oil reserves and gas fields around all over the world justify the deepening of studies to render viable the larger-scale use of new energy sources. Therefore, the use of microorganisms to convert sugars into ethanol is a feasible process to be performed in a short period of time and at low costs. In this context, this study  aimed to select ethanol-producing yeasts, after isolating samples from molasses  obtained from companies in the Province of Tucumán (Argentina) and grapes obtained from farms located in Cafayate (Salta, Argentina). Among the twenty-nine samples studied A2, A10 and A11 isolates showed higher ethanol productions of  12.87; 13.64 and 13.46% respectively. A2 showed a homogeneous growth meanwhile the growth of strains A10 and A11 was flocculent. Molecular taxonomic characterization of these isolates showed a percentage of similarity of 100% with the strain Saccharomyces cerevisiae. The behavior of the non-flocculent A2 strain at laboratory sclae was faster using a sugarcene molasses based medium, reaching 11.36% ethanol without adding nutrients and other growth factors, probably because its disperse form facilitates the transfer of nutrients and products.  These values were improved to 12.02% when the process was scaled up to a 10L bioreactor. All these studies allowed concluding that S. cerevisiae A2 strain is a promising  microorganism for the production of bioethanol with potential environmental, energy and economic benefits to  be projected into industrial scale.","palabras_clave":"BIOETHANOL|SCALE UP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":788,"idioma_id":5,"titulo":"Procesos de perdón y reconciliación en argentina: aportes para una mejor comprensión de los efectos de la violencia de estado.","resumen":"Este trabajo  evalúa el grado de conocimiento y la percepción de sinceridad y eficacia de las  disculpas públicas efectuadas luego de la violencia de Estado ocurrida en la  última dictadura militar. Asimismo, se indaga en la disposición al perdón y en  la deseabilidad de  reconciliación. La muestra estuvo compuesta por 518 participantes (Edad: M = 35.58;  SD = 13.62) entre los que se encuentran víctimas directas e indirectas  de la violencia y personas no afectadas. Los resultados revelan escaso conocimiento de  las disculpas ofrecidas, así como bajos niveles de eficacia percibida en su  objetivo restaurativo. Se observan diferencias según el auto-posicionamiento  ideológico y la edad de los participantes. Los más jóvenes y las personas de  izquierda son quienes consideran menos necesario el pedido de perdón, presentan  una menor creencia sobre la disposición a perdonar por parte de los afectados y  quienes, en menor medida, desean la reconciliación.","palabras_clave":"PERDON INTERGRUPAL|RECONCILIACION|JUSTICIA RESTAURATIVA|DICTADURA MILITAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":789,"idioma_id":5,"titulo":"La tecnicidad humana y animal en un marco naturalista. Problemas y perspectivas en el debate contemporáneo","resumen":"El trabajo defiende una distinción entre dos modos de relación técnica con el entorno, propias de los animales humanos y de los no humanos respectivamente. En primer lugar, se critica una posición naturalista 'ecológica' o 'contextualista', que no permite tal distinción, y que se encuentra en autores como Preston e Ingold. En segundo lugar, se introduce la noción de 'affordance intencional', propuesta por Tomasello, para caracterizar la tecnicidad propiamente humana. En tercer lugar, se esbozan los momentos de una concepción gradualista de la técnica que permita a la vez pensar la diferencia específica de la tecnicidad humana. ","palabras_clave":"DIFERENCIA ANTROPOLOGICA|GRADUALISMO|PRESTON E INGOLD|AFFORDANCE INTENCIONAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":790,"idioma_id":5,"titulo":"Algo más sobre un mítico seminario (usina teórica de la universidad argentina de la posdictadura)","resumen":"Este artículo analiza la relación entre teoría, crítica y enseñanza articulada en el Seminario «Algunos problemas de Teoría Literaria» liderado por Josefina Ludmer en 1985 en la Universidad de Buenos Aires (Argentina). En primer lugar, se describen los núcleos teóricos del Seminario. Paralelamente, se caracterizan las operaciones críticas desplegadas en su desarrollo. Finalmente se explora el programa de investigación y de formación que Ludmer proyecta o, en otras palabras, se descubren sus «fantasías de nano-intervención» en la universidad argentina y pública de los primeros años de la posdictadura.&nbsp; ","palabras_clave":"JOSEFINA LUDMER|POSDICTADURA|TEORÍA LITERARIA|FANTASÍAS DE NANO-INTERVENCIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":791,"idioma_id":5,"titulo":"La contraofensiva parauniversitaria durante la última dictadura argentina: el caso de 'Lecturas críticas'","resumen":"Este artículo describe una de las producciones originadas en el marco de las prácticas de investigación clandestinas desarrolladas en el campo de la teoría y la crítica literarias en Argentina durante la última dictadura (1976-1983): la revista Lecturas críticas. Una publicación ligada a la universidad de las catacumbas: formación que ejerció la resistencia a través de la actualización, la traducción, la discusión y la producción teórica y crítica. En primer lugar, se caracterizan los temas, autores e interrogantes transitados por la revista; paralelamente se describen las operaciones de lectura desplegadas y promovidas. Finalmente, se puntean algunas de sus derivas en las prácticas de investigación y de enseñanza universitarias de la democracia.","palabras_clave":"ARGENTINA|DICTADURA|UNIVERSIDAD DE LAS CATACUMBAS|CLANDESTINIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":793,"idioma_id":5,"titulo":"Presas del nuco (Asio flammeus) en un área de pastizal pampeano de Argentina","resumen":"We describe the prey of the Short-eared Owl in a Pampas grassland area of Argentina on the basis of pellets occasionally collected (N = 10). We found a high proportion of small mammals within samples (80% by number and 97% by biomass). Pellets also contained a very small number of insects and an avian prey. Prey spectrum of this owl species in our study site was similar to those described on other previous studies. Presence of rodents that typically inhabit native grasslands in the study area suggests that the Short-eared Owl could be exploiting less human-impacted areas as hunting habitats.","palabras_clave":"ASIO FLAMMEUS|PAMPAS GRASSLAND|SMALL MAMMALS|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":795,"idioma_id":4,"titulo":"Osteosarcoma in the Skull of a Holstein Heifer.","resumen":"A-2-years-old heifer showed a mass on the frontal part of the skull. Cytological analysis displayed pleomorphic, polyedric and fusiform cells with extracellular hyaline material. Histologically, the excised mass showed proliferation of spindle-to-polyhedral cells that exhibited anisocytosis and anisocaryosis. Osteoid substance was demonstrated by Masson´s thricromic stain. Tumoral cells and osteoid expressed osteocalcin. This case report communicates a very rare osteosarcoma in the corneal process of a young heifer. As the heifer was previously dehorned, it is possible that this procedure was a predisposing factor for malignant growth.","palabras_clave":"cattle| cornual process|osteosarcoma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":796,"idioma_id":4,"titulo":"Endometrial cytology as a diagnostic tool for subclinical endometritis in beef heifers","resumen":"Abstract: The obstetric assistance of dystocia in field conditions promotes greater bacterial contamination of the uterus, causingsubclinical endometritis. The aim of this study was to determine the occurrence of subclinical endometritis in beef heifers receivingprofessional calving assistance, and to evaluate endometrial cytology as a diagnostic technique compared to uterine biopsy. A group of829 Angus heifers were assisted at calving. Dystocia was classified based on difficulty at assistance, which was estimated as complex orsimple. At the end of the calving season, 93 dystocic heifers were reported (10.7%). The percentage of simple resolution and complexresolution was 88.2% and 11.8%, respectively. After 60 days of calving, all animals underwent a gynecological examination, endometrialcytology, and uterine biopsy. In all, 38.9% of heifers presented subclinical endometritis diagnosed by endometrial cytology (sensitivity =78.6%, specificity = 95.8%). There was a significant association (r = 0.8528) between uterine cytology and uterine biopsy. No associationswere observed between endometrial cytology or biopsy and calf viability, or between endometrial cytology or biopsy and calvingresolution. Endometrial cytology is a noninvasive technique with high specificity and repeatability for the diagnosis of subclinicalendometritis postpartum in dystocic beef heifers.Key words: Beef heifers, cytology, biopsy, dystocia, subclinical endometritis","palabras_clave":"CITOLOGIA|DIAGNOSTICO|ENDOMETRITIS|SUBCLINICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":797,"idioma_id":5,"titulo":"Primer registro de depredacion de huevos de anuros por sanguijuelas en Argentina","resumen":"La depredación de huevos por sanguijuelas es unade las causas de mortalidad temprana de anuros(Elkhan, 1976; Chivers et al., 2001). En la mayoríade los casos se trata de especies de sanguijuelas queactúan como depredadores ocasionales, atacandoincluso a adultos o renacuajos; sin embargo se hanregistrado especies altamente adaptadas en la depredaciónde huevos de anfibios representando estos suúnico alimento (Burgin y Schell, 2005). Esta relacióndepredador-presa ha promovido varios estudios,enfocándose principalmente en los mecanismosde defensa de los anuros (e.g. palatabilidad de loshuevos, disposición de las puestas, ver Chivers etal., 2001; Turbeville y Briggler 2003; Håkansson yLoman, 2004; Gunzburger y Travis 2005).En la región Neotropical estas observacionesson muy escasas, limitándose a un evento de depredaciónde huevos de Rhinella dorbignyi por unaespecie no identificada de sanguijuela en Rio Grandedo Sul, Brasil (Loebmann et al., 2008), mientras queen Argentina aún no existen citas publicadas asociadasa este tipo de interacción depredador-presa.En la presente nota se reportan los primeros datosde depredación de huevos de anuros por sanguijuelas(Oxyptychus sp.) en las Sierras de Tandilla enArgentina.u","palabras_clave":"DEPREDACION|HUEVOS|ANUROS|SANGUIJUELAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":798,"idioma_id":5,"titulo":"Diseño e indumentaria: Una mirada histórica sobre las estéticas de las identidades de género","resumen":"        Este trabajo tiene como  objetivo principal realizar una historia social del campo del diseño de  indumentaria desde una perspectiva de género. Con tal fin, se hace referencia  al siglo XIX, momento en que se polarizaron con mayor énfasis las formas de  vestir de acuerdo a las diferencias anatómicas binarias entre mujeres y  varones. Esto es, en el siglo XIX se acentuaron las diferencias en las maneras  de vestir femeninas y masculinas como opuestas y excluyentes. Por esta razón,  este artículo propone pensar la indumentaria como un objeto sociológico y semiótico  que comunica y produce a través del diseño características de la sociedad que  atañen a la corporalidad y la regulación de la sexualidad&nbsp; a través de prácticas estéticas.&nbsp;   ","palabras_clave":"género|indumentaria|diseño|estética"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":799,"idioma_id":4,"titulo":"AtHB1, an Arabidopsis thaliana HD-Zip I Transcription Factor, is regulated by Phytochrome-Interacting Factor 1 to promote hypocotyl elongation","resumen":"        ·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  AtHB1 is a  homeodomain-leucine zipper transcription factor described as a transcriptional  activator with unknown function. Its role in Arabidopsis thaliana development was investigated.        ·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  AtHB1  expression was analyzed in transgenic plants bearing its promoter region fused  to reporter genes. Knock-down mutant and  overexpressor plant phenotypes were analyzed in different photoperiod regimes.         ·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  AtHB1  is mainly expressed in hypocotyls and roots and up-regulated in seedlings grown  under a short-day photoperiod. AtHB1 knock-down mutants and overexpressors showed  shorter and longer hypocotyls, respectively, than WT. AtHB1 transcript levels were lower in Phytochrome-Interacting Factor 1 (PIF1) mutants than in controls, suggesting that AtHB1 is regulated by PIF1 in hypocotyls. GUS activity in  tobacco leaves co-transformed with PromAtHB1::GUS  and 35S::PIF1 indicated that PIF1 induces  AtHB1 expression. Hypocotyl length  measurements in seedlings grown in short- or long-day athb1, pif1, or double athb1\/pif1 mutants and PIF1 or AtHB1 overexpressors in WT, athb1 or pif1 backgrounds allowed us to determine that AtHB1 is a PIF1  downstream component. Finally, a transcriptome analysis of athb1 mutant hypocotyls revealed that AtHB1 regulates genes  involved in cell wall composition and elongation.         ·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  The results suggest  that AtHB1 acts downstream of PIF1 to promote hypocotyl elongation, especially  in response to short-day photoperiods.  ","palabras_clave":"factor de transcripción|AtHB1|PIF1|elongación hipocotilos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":802,"idioma_id":4,"titulo":"A potential invasion route of Cactoblastis cactorum within the Caribbean region matches historical hurricane trajectories","resumen":"The cactus moth, Cactoblastis cactorum mainly distributed throughout central and northeastern Argentina was intentionally introduced in the Caribbean region in 1957 as a biological control agent of cacti species of the genus Opuntia. This moth invaded during the last 20-30 years the North American continent, threatening the major center of biodiversity of native Opuntia species. Although human induced and natural dispersal have been invocated to explain its expansion in the non-native distribution range, there is still no evidence to support natural dispersal. In particular, hurricanes are one of the major environmental factors affecting species dispersal in the region. In this study we used mitochondrial DNA to examine whether the spatial distribution of haplotype variation of C. cactorum is at least partially explained by hurricane trajectories within the Caribbean region. DNA sequences for the mitochondrial gene cytochrome oxidase I were obtained for a sample of 110 individuals from the Antillean islands. This information was combined with existing sequences in the GenBank for the same gene for the Caribbean and Florida (N = 132 sequences). Genetic diversity descriptors, a haplotypic network, a spatial analyses of molecular variance and a landscape genetic analysis of migration conditioned by hurricane tracks were conducted to test our hypothesis. Our results revealed a signi&#64257;cant spatial grouping of haplotypes consistent with the more frequent hurricane trajectories in the Caribbean region. Signi&#64257;cant isolation by distance conditioned by hurricane tracks was detected. Populations of Florida were genetically closer to those of Cuba than to the rest of the population sampled. Within the region, Cuba appears as a reservoir of genetic diversity increasing the risk of invasion to Mexico and the US. Despite commercial transportation of Opuntia promoted dispersal to Florida, our results support the hypothesis that natural disturbances such as hurricanes played a role dispersing this invasive insect. Future conservation programs of North American Opuntia species requires taking into account hurricane mediated dispersal events and permanent whole regional monitoring and international control policies to prevent future range expansions of C. cactorum.","palabras_clave":"plant-animal interactions|biological invasions|biological control|climatic effects"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":803,"idioma_id":4,"titulo":"Comparison of two detection systems to reveal AFLP markers in plants","resumen":"Since their development, AFLP (amplified fragment length polymorphism) markers have been used for a wide variety of analyses and, up to this day, are considered highly informative, robust, and reproducible molecular markers. Originally, the visualization of the amplified fragments was done in polyacrylamide gels, followed by silver staining or by developing in an X-ray plate, when radioactivity is used. In the last 14 years, capillary electrophoresis of fluorescently labeled fragments has been gradually replacing gel-based systems. However, the latter continue to be better for isolating and cloning AFLP fragments. In this report, we compare the results obtained by capillary electrophoresis with those from silver staining. We found that if fluorescencelabeled amplification products are loaded in a polyacrylamide gel, duplicated bands (doublets) are seen. This phenomenon is probably due to a delay in the migration of the strand that carries the fluorophore. Therefore, we recommend a minimum separation of 4 bp from the nearest fragment to the target fragment for its unambiguous identification and isolation. If this requirement is not fulfilled, an alternative is to make new amplifications using the same primer combination, but with unlabeled primers.","palabras_clave":"AFLP|CAPILLARY ELECTROPHORESIS|SILVER STAINING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":804,"idioma_id":4,"titulo":"Separation and purification of sepiolite fibers. Contribution to special processing for industrial use","resumen":"In this work, lyophilization and acid treatments were proposed as simple alternatives to defiber sepiolite samples, without affecting their length, in order to be applicable at industrial scale. Although it contains carbonates,themain remarkable feature of this clay mineral is its high crystalline development, reaching fiber lengths around 8 cm. Proposed alternatives were analyzed comparatively, evaluating mainly the defibering effect. The influenceof lyophilization and acid treatments on sepiolite structure and purity was qualitatively studied based on mineral characterization, electronic and optical microscopy, X-ray diffraction and Fourier transform infrared spectroscopy.Results show that acid treatment allowed sepiolite purification by removing carbonates as well as the reduction of fiber length. Lyophilization demonstrated to be an effective defibering process that allowed obtaining individualized fiber from bundle disaggregation, without affecting sepiolite length and flexibility.","palabras_clave":"sepiolite|fibers|clay minerals"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":805,"idioma_id":4,"titulo":"Comparative analysis of the effects of homocastasterone and two derivatives on shoot and main root elongation of tomato plantlets","resumen":"Brassinosteroids (BRs) comprise a specific class of low-abundance plant   steroids of ubiquitous occurrence in plants. Molecular genetic analysis   of mutants defective in BRs biosynthesis or response has demonstrated   that the ability to synthesize, perceive and respond to BRs is critical   for normal plant growth. In this work, the structure-activity   relationships of two synthetic derivatives of 28-homocastasterone   (28-HCS) were evaluated on tomato plantlets using the native 28-HCS and   epibrassinolide (epi-BL) as control. Progressive enhancement in the main   root elongation was found for plantlets treated with increased doses of   5&#945;-fluoro-28-homocastasterone (5F-HCS) within the 0.5?4&nbsp;&#956;g&nbsp;shoot&#8722;1 Range. When compared to epi-BL, to the parental 28-HCS and to a mono   5-hydroxy HCS derivative (5OH-HCS), no difference between 5F-HCS and the   other BRs, towards stimulation of main root elongation, was found when   these BRs were applied at a dose of 2.0&nbsp;&#956;g per plantlet. Both, 5F-HCS   and 5OH-HCS significantly enhanced shoot elongation, though   significantly less than HCS and epi-BL did. Besides provinding an   insight into the morphological responses of tomato plantlets to   application of 28-HCS derivatives, these results also demonstrate that   the 5F-HCS-induced stimulation of main root elongation might be useful   to improve the plants´s nutrient and especially water uptake,   particularly under water deficit, besides improving anchorage.","palabras_clave":"28-HOMOCASTASTERONE   |BRASSINOSTEROIDS|LYCOPERSICUM ESCULENTUM  |ROOTING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":806,"idioma_id":5,"titulo":"Memoria,proscripción y exclusión política en Río Negro 1955-1966","resumen":"La proscripción del peronismo constituyó una de las manifestaciones más visibles de exclusión política. En la provincia de Río Negro creada en 1955, la construcción de la memoria histórica se relacionó estrechamente con la necesidad de justificar la proscripción peronista. La memoria como interpretación colectiva de los hechos del pasado que se quiere salvaguardar, es un componente importante del sentimiento de continuidad, cohesiona grupos, define lugares y oposiciones. En Río Negro, la memoria sobre el pasado peronista fue resignificada poniendo el centro en sus aspectos más negativos como parte de una historia  a superar. En este recorte de la memoria histórica, ocuparon un rol fundamental los objetivos  de la autodenominada 'Revolución Libertadora', que perduraron en el tiempo y fueron avalados discursivamente por los primeros gobiernos constitucionales rionegrinos. De este modo, el perfil de la nueva provincia se cimentó sobre una matriz excluyente sostenida por la deconstrucción de la memoria histórica, una de las posibles claves interpretativas de la emergencia de una democracia débil  y atravesada por una conflictividad persistente.","palabras_clave":"MEMORIA|PROSCRIPCION|PERONISMO|EXCLUSION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":807,"idioma_id":4,"titulo":". Tectono-stratigraphic evolution of the Andean Orogen between 31º and 37ºS (Chile and Western Argentina).","resumen":"In this classic segment, many tectonic processes, like flat-subduction, terrane accretionand steepening of the subduction, among others, provide a robust framework for their understanding. Five orogenic cycles, with variations in location and type of magmatism, tectonicregimes and development of different accretionary prisms, show a complex evolution. Accretionof a continental terrane in the Pampean cycle exhumed lower to middle crust in Early Cambrian.The Ordovician magmatic arc, associated metamorphism and foreland basin formation characterized the Famatinian cycle. In Late Devonian, the collision of Chilenia and associated highpressure\/low-temperature metamorphism contrasts with the late Palaeozoic accretionary prisms. Contractional deformation in Early to Middle Permian was followed by extension and rhyolitic (Choiyoi) magmatism. Triassic to earliest Jurassic rifting was followed by subduction and extension, dominated by Pacific marine ingressions, during Jurassic and Early Cretaceous. The Late Cretaceous was characterized by uplift and exhumation of the Andean Cordillera. An Atlanticingression occurred in latest Cretaceous. Cenozoic contraction and uplift pulses alternate with Oligocene extension. Late Cenozoic subduction was characterized by the Pampean flat-subduction, the clockwise block tectonic rotations in the normal subduction segments and the magmatism in Payenia. These processes provide evidence that the Andean tectonic model is far from a straightforward geological evolution.","palabras_clave":"TECTONICS|ARGENTINA-CHILE ANDES|TERRANES|CHILENIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":810,"idioma_id":4,"titulo":"Forming limit curve determination of a DP-780 steel sheet","resumen":"In the present work, the forming limit curve (FLC) of a 1.1 mm thick DP-780 steel sheet is evaluated. The full FLC determination involved tensile tests of planar samples with different notch geometries ? providing data in the tension-compression range ? and Nakajima tests with a 40 mm diameter hemispherical punch and different notch geometries, covering the full loading zone of the forming limit diagram. The proposed Nakajima tool geometry reduces the standard test dimensions (ISO 12004-2) by 60%. Results show that the reduced diameter Nakajima test, in the particular case of Dual-Phase steels, overestimates limit strains when compared to the tensile test. This observed difference is explained in terms of the presence of a strain gradient through the sheet thickness imposed by the 40 mm diameter Nakajima punch, leading to the conclusion that this reduced sample type is not suitable for FLC determination when the DP-780 steel sheet is more than a millimeter thick.","palabras_clave":"DP steel|Forming limit|Nakajima|DIC technique"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":813,"idioma_id":4,"titulo":"EFFECTS OF FEEDING ON THE PLASMA DISPOSITION KINETICS OF THE ANTHELMINTIC ALBENDAZOLE IN LAYING HENS","resumen":"1. To optimize the use of ABZ as an anthelmintic in hens, the effects of fasting and type of diet on the plasma kinetics of ABZ and its metabolites were evaluated. 2. Twenty four hens were distributed into four groups: Experiment I: Fed-group fed ad libitum; Fasted-group was fasted over a 12 h period. Experiment II: Pelleted-group fed with pelleted commercial food; Grain-group fed with cereal grains. All groups were treated with ABZ by oral route. Blood samples were taken and plasma analysed by HPLC. 3. ABZ and its metabolites ABZSO and ABZSO2 were recovered in plasma in all the groups. The 12 h fasting period did not modify the disposition kinetics of ABZ in hens. The type of feed affected ABZ kinetics. ABZSO concentration profile was higher and detected longer in the Grain-group compared to the Pelleted-group. Statistical differences were not found for AUC0-&#8734; values, meanwhile the T1\/2for and T1\/2el were different between groups. 4. Factors affecting ABZ kinetic behaviour should be considered to optimise its use to ensure the sustainability of the limited available anthelmintic therapeutic tools in avian parasite control.","palabras_clave":"ALBENDAZOLE|RESIDUOS|HUEVOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":814,"idioma_id":4,"titulo":"Lama Guanicoe (Muller, 1776) body size in continental Patagonia and Tierra del Fuego","resumen":"Lama guanicoe (Muller, 1776) is one of the most important South American large mammal species for both biologists, ecologists and archaeologists, and body size of modern and prehistoric populations of guanaco has been one of the most studied parameters. In this paper, we evaluate the latitudinal differences in body size of different modern populations of guanaco from Argentinean Patagonia based on osteometric data of their long bones. The osteological sample is made of 110 fully-fused individuals drawn from three different guanaco populations from continental and insular Patagonia covering the latitudinal interval from S40° to S54.5°. Quantitative data for the four long bones selected are analyzed with univariate and multivariate parametric statistical techniques. Apparently consistent with Bergmann's rule, results show that guanaco specimens from S53-54.5° are bigger on average than those from S48-52° which are, in turn, bigger than those from S40°. We observe a high and significant covariation between different environmental variables (maximum temperature, net primary production, and winter precipitation) and body size of the guanaco populations. Nevertheless, when the temporal factor is incorporated into the analysis of this geographical gradient of body size the scenario becomes more complex. We conclude that the current clinal pattern observed in Patagonia is the result of several microevolutionary and biogeographic processes related to an adjustment of body size to different environmental and ecological drivers and to the consequences of isolation in Tierra del Fuego that occurred around the Pleistocene-Holocene transition.","palabras_clave":"GUANACO|BODY SIZE|ENVIRONMENTAL VARIABLES|BERGMAN'S RULE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":815,"idioma_id":4,"titulo":"Hydrodynamics of phase transition fronts and the speed of sound in the plasma","resumen":"The growth of bubbles in cosmological first-order phase transitions involves nontrivial hydrodynamics. For that reason, the study of the propagation of phase transition fronts often requires several approximations. A frequently used approximation consists in describing the two phases as being composed only of radiation and vacuum energy (the so-called bag equation of state). We show that, in realistic models, the speed of sound in the low-temperature phase is generally smaller than that of radiation, and we study the hydrodynamics in such a situation. We find in particular that a new kind of hydrodynamical solution may be possible, which does not arise in the bag model. We obtain analytic results for the efficiency of the transfer of latent heat to bulk motions of the plasma, as a function of the speed of sound in each phase.","palabras_clave":"Cosmological phase transitions|Bubble wall|Relativistic hydrodynamics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":816,"idioma_id":5,"titulo":"Nuevas miradas sobre el Estado, lo local, lo global y los estudios comparados en educación","resumen":"Los vínculos conceptuales entre Estado y educación han sido analizados desde diferentes disciplinas durante los últimos siglos y, los análisis contemporáneos, han considerado nuevas perspectivas analíticas derivadas de la intensificación de los procesos de internacionalización de las sociedades y de sus sistemas educativos. En este sentido, la Educación Comparada, en tanto disciplina que nació ligada a la configuración de los sistemas educativos estatales, ocupó y ocupa un lugar central en el estudio de las nuevas relaciones en el Estado y los sistemas de escolarización.En esta oportunidad, la Revista Latinoamericana de Educación Comparada concentra su sección monográfica en las Nuevas miradas sobre el Estado, lo local, lo global y los estudios comparados en educación. Esta selección temática a su vez se deriva del Grupo Temático n° 3 del XV Congreso Mundial de Educación Comparada, organizado por el Consejo Mundial de Sociedades de Educación Comparada y la Sociedad Argentina de Estudios Comparados en Educación, que tuvo lugar en Buenos Aires en junio de 2013. Este grupo temático convocó a la presentación de trabajos sobre el cambio del rol del Estado en políticas y prácticas educativas en el contexto de la globalización. Incluyó también trabajos referidos a los cambios en la comprensión de lo global y lo local y las nuevas relaciones entre el Estado y la sociedad civil, entre lo público y lo privado, y entre ciudadanos y comunidades. Buscó asimismo pensar los efectos de las tendencias mundiales en la formulación de políticas locales, y las tensiones entre actores políticos y organizaciones que participan en el diseño e implementación de reformas educativas.","palabras_clave":"ESTADO Y EDUCACION|GLOBAL Y LOCAL|ESTUDIOS COMPARADOS EN EDUCACIÓN|AMÉRICA LATINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":817,"idioma_id":4,"titulo":"Automated support for diagnosis and repair","resumen":"Model checking and logic-based learning together deliver automated support, especially in adaptive and autonomous systems.","palabras_clave":"Model|Checking"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":819,"idioma_id":5,"titulo":"Semana del Diseño y la Comunicación","resumen":"Las actividades de la Facultad de Diseño y Comunicación no sólo se limitan a la enseñanza áulica. La SEMANA DEL DISEÑO es un evento donde los alumnos y público en general puede conocer experiencias profesionales y también de emprendimientos de jóvenes profesionales que intentan hacerse un camino laboral.","palabras_clave":"UNIVERSIDAD|ACTIVIDAD EXTRACURRICULAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":820,"idioma_id":4,"titulo":"The burden of diabetes in Argentina","resumen":"Objective: To measure the economic burden of diabetes in Argentina by age, gender and region for the year 2005, in disability-adjusted life years (DALYs).    Methods: DALYs were estimated by the sum of years of life lost due to premature death (YLL) and years of life lived with disability (YLD).    Results: In the population studied (20 to 85 years), the burden of diabetes without complications was 1.3 million DALYs, 85% of which were caused by disabilities. Whereas mortality rates (YLL) increased as a function of age, YLD showed the opposite relationship. Women had higher burden of disease values, represented by 51 and 61% of YLL and YLD, respectively, independently of age.    Conclusions: Our results demonstrate that disabilities are a key component of diabetes burden; its regular and systematic estimation would allow to design effective prevention strategies, to assess the impact of their implementation and to optimize resource allocation based on objective evidence.","palabras_clave":"Diabetes|DALYs|Mortality|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":821,"idioma_id":5,"titulo":"Debates sobre Ciudadanía y Ambiente","resumen":"Desde fines del siglo XX la cuestión del impacto antrópico sobre el ambiente es de interés científico, político y filosófico, en ese sentido interesa debatir acerca de  la interrelación entre el ambiente y el ejercicio de la ciudadanía. Diferentes enfoques surgen de principios de filosofía política que dan cuenta de distintas perspectivas respecto de la relación del hombre con la naturaleza. Las posiciones radicales antropocentristas consideran al individuo lo único importante y que la naturaleza, pero también las comunidades, las culturas y las instituciones humanas no tienen más que un valor de carácter instrumental. Otras más ambientalistas, consideran que las preferencias humanas deben apoyarse en una concepción del mundo integralmente asumida.  Entre los enfoques ambientalistas centramos este trabajo en el estudio de las ecofilosofías referidas a: la ciudadanía ecológica, el buen vivir y la ecología política. Los componentes esenciales de cada una de ellas nos aproximan a un nuevo modo de pensar que tratan de superar las deficiencias del pensamiento moderno que dominó occidente desde el siglo XVI, caracterizado  por el individualismo voluntarista, la validación de la razón científica; y el predominio de las instituciones del Estado y el mercado, como constituyentes del hombre y de la sociedad.   Las ecofilosofías analizadas ponen en cuestión el proyecto de la modernidad aportando alternativas que integran el ejercicio de la ciudadanía, con un enfoque global, multicultural y coherente sobre el vínculo del hombre con la naturaleza, orientado a una conciencia ética ecológica.","palabras_clave":"ECO FILOSOFIAS|AMBIENTE|CIUDADANIA|ÉTICA ECOLÓGICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":822,"idioma_id":5,"titulo":"LA MIGRACIÓN DEL CRONOTOPO DE AUTORIDAD EN EL CUENTO DE LA NODRIZA Y ?LA LUCIANA?","resumen":"La memoria posee capacidad para simbolizar y experimentar: amor, odio, miedo,vulnerabilidad, etc. Ésta es una memoria no discursiva que está vinculada al concepto de embodiment, (Braidotti, 2009) término que tiene su punto de partida en el concepto de habitus de Pierre Bourdieu. A través de estos conceptos, se observa cómo una memoria pasada atraviesa la experiencia corporal y emocional. El proyecto de procreación Nazi Lebensborn (1935-1946) y los Centros de Detención Clandestina en Argentina (1976-1983) poseen tópicos que hacen posible justificar el escape hacia la literatura fantástica. Se precisa que los antecedentes históricos son una fuente de inspiración para producciones literarias genéricamente diferentes. El planteo de esta comunicación es el siguiente: ¿Qué sucede si hechos históricos completamente alejados tienen un punto en común en una novela distópica canadiense (El Cuento de la Criada, Margaret Atwood, 1985) y en un poema de un autor regional catamarqueño (?La Luciana?, Jorge Paolantonio, 2011). Se parte del supuesto metodológico que postula a la ficción como visibilización de la realidad histórica desde sucontexto de producción, ya sea este canadiense o regional argentino. Se propone como herramienta de análisis la idea de cronotopo presentada por Mijail Bajtin, (1989). Éste hace posible la fusión de los indicios espaciales y temporales en un todo consciente y concreto. Condensadores de tiempo, espacio e ideología, la cronotopía entabla nexos poderosos cargados de reflexividad. Son enclaves temporales dónde se negocian y reinterpretan identidades. Como resultado existe migración del cronotopo del comandante en Atwood, del militar en Paolantonio y los ritos sistémicos en las obras propuestas.","palabras_clave":"Atwood|Bajtín|cronotopos|Lebensborn"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":823,"idioma_id":4,"titulo":"Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies","resumen":"It was demonstrated that Ligaria cuneifolia (Lc) crude extract increased blood viscosity and decreased plasma&nbsp;cholesterol in rats. In the present study, we analyzed the Lc proanthocyanidin enriched fraction (PLc) to determine if it is capableof altering the hemorheological parameters while diminishing the plasma cholesterol. In vivo studies in adult male Wistar rats,&nbsp;randomized in three groups (n = 6 each one) were performed: 1. Control: saline intraperitoneal (i.p.); 2. PLc 0.6mg\/100 g body&nbsp;weight (b.w.) i.p. and 3. PLc 3mg\/100 g b.w. i.p., every 24 hours during 3 days. In vitro studies: with blood obtained by cardiacpuncture, separated in aliquots and incubated with: 1. Saline solution (Control); 2. PLc 0.1mg\/mL, and 3. PLc 1.0mg\/mL,equivalent to doses in vivo experiments. The results demonstrated that in vivo PLc 0.6 and PLc 3 reduced plasma cholesterol(Cho) and LDL-Cho. Neither blood nor plasma viscosity was altered. Decrease of plasma cholesterol could be due to an increaseof cholesterol and bile salts excretion leading to an increase of bile flow. In vitro experiments showed a direct interaction of PLc, at high concentration, with the erythrocyte membrane, inducing a switch from discocyte to stomatocyte. Only, PLc without hepatic&nbsp;metabolism produces hemorheological changes. Thus, PLc in vivo might be a pharmacological agent capable of decreasingplasma cholesterol.","palabras_clave":"Ligaria cuneifolia|Biliary excretion|Blood viscosity|Erythrocyte deformability|Plasma cholesterol|Proanthocyanidin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":825,"idioma_id":5,"titulo":"El poder dentro de la fábrica. El proceso de cambios en la organización del trabajo en la planta de Acindar en Villa Constitución","resumen":"                En  este artículo mostraremos cómo se configura la praxis empresarial de Acindar a  partir de la represión a los trabajadores, y fundamentalmente cómo se monta la  reorganización del trabajo en un marco de disciplinamiento de la fuerza de  trabajo.              Conceptualmente,  nos referimos a la praxis empresarial como categoría de mediano  alcance, que nos permiten reenviar los procesos estudiados en el suelo de la  fábrica al proceso hegemónico. De esta forma, las categorías de praxis empresarial y praxis de los trabajadores, nos remiten  a la unidad entre teoría y práctica, con el alcance político que implica la  relación estudiada, en el sentido de configurar y formar parte de un proceso  hegemónico particular. Es así que cualificamos las acciones, las estrategias,  las políticas, los discursos, los sentidos (las lógicas de concepción y  conceptualización, las apreciaciones y conceptualizaciones), de los sujetos  estudiados, como praxis, que recupera  la dimensión de los sujetos en la construcción de hegemonía. De esta forma,  entendemos como constitutivos de la praxis todo aquello que hace de ella la  unidad entre la teoría y la práctica en articulación con las relaciones  sociales concretas (Giniger, 2012).                De  esta forma, nos sumergiremos en el proceso de transformación de la praxis empresarial, que modifica uno de sus pilares más importantes:  la organización del trabajo. Este proceso llamado reconversión productiva tiene cuatro hitos fundamentales, que comenzaron  con el Terrorismo de Estado, en los cuales la política de organización del  trabajo se especializó y sofisticó: la puesta en marcha de la acería  (1976-1978), la deslocalización y cierre de unidades productivas (1985-1987),  el conflicto por los Nuevos Métodos de Trabajo (1991) y la venta de Acindar  (2000).  ","palabras_clave":"ORGANIZACIÓN DEL TRABAJO|PRAXIS EMPRESARIAL|PROCESO PRODUCTIVO|SIDERÚRGICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":826,"idioma_id":5,"titulo":"Estimación de interferencias en la determinación de fructuosamina en suero de felinos y caninos","resumen":"La concentracion de fructosamina en suero es util para monitorear el control de la glucemia en un período precedente. En muestras de sangre la presencia de hemoglobina (Hb) y bilirrubina (Bb) pueden causar interferencias en técnicas analíticas diagnosticas. Por ello, el objetivo de este trabajo fue evaluar la posible interferencia al medir fructosamina serica de gatos y perros clinicamente sanos. Se construyeron interferogramas, agregando concentraciones crecientes del posible interferente a pools de sueros de ambas especies. Se estudiaron concentraciones de Hb desde 0,19 a 7,5 g\/l en felinos y, 0,16 a 6,10 g\/l  en caninos. Para Bb desde 6 a 600 mg\/l en ambas especies. Los resultados mostraron interferencias positiva y aditiva de Hb en felinos (mayor 1.60 g\/l) e interferencia negativa en caninos (mayor a 1.20 g\/l). En ambas especies se observaron interferencias positivas y aditivas para bilirrubina en el rango de concentraciones estudiadas (mayor a 30 mg\/L para felinos y mayor a 150 mg\/l para caninos)","palabras_clave":"INTERFERENCIAS|FRUCTOSAMINA|CANINOS|FELINOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":827,"idioma_id":4,"titulo":"Enhanced Singlet Oxygen Production by Photodynamic Therapy and a Novel Method for Its Intracellular Measurement","resumen":"The generation of singlet oxygen (SO) in the presence of specific photosensitizers (PSs) or semiconductor quantum dots (QDs) and its application in photodynamic therapy (PDT) is of great interest to develop cancer therapies with no need of surgery, chemotherapy, and\/or radiotherapy. This work was focused on the identification of the main factors leading to the enhancement of SO production using Rose Bengal (RB), and Methylene Blue (MB) as PS species in organic and aqueous mediums. Subsequently, the capacity of zinc oxide (ZnO), zinc sulfide (ZnS), and ZnO\/ZnS core-shell QDs as well as manganese (Mn+2) doped ZnO and ZnS nanoparticles (NPs) as potential PS was also investigated. Many variable parameters such as type of quencher, PSs, NPs, as well as its different concentrations, light source, excitation wavelength, reaction time, distance from light source, and nature of solvent were used. The degradation kinetics of the quenchers generated by SO species and the corresponding quantum yields were determined by monitoring the photo-oxidation of the chemical quencher and measuring its disappearance by fluorometry and spectrophotometry in the presence of NPs. Small intracellular changes of SO induced by these metal Zn (zinc) NPs and PDT could execute and accelerate deadly programs in these leukemic cells, providing in this way an innovative modality of treatment. In order to perform further more specific in vitro cytotoxic studies on B-chronic lymphocytic leukemia cells exposed to Zn NPs and PDT, we needed first to measure and ascertain those possible intracellular SO variations generated by this type of treatment; for this purpose, we have also developed and tested a novel method first described by us.","palabras_clave":"Nanoparticles|Oncology|Leukemia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":828,"idioma_id":4,"titulo":"'Motor Clubs in the Public Arena: the Argentine Automobile Club, the Argentine Touring Club and the construction of a National Roads System (1910-1943)'","resumen":"The rapid spread of the automobile in the early twentieth century posed both challenges and promises to nation states. Before                     automobility became the object of public policies, this new mobility technology had to be socially perceived and constructed                     as belonging to the public sphere. Motorist associations played a decisive role in this process. This paper focuses on the                     Argentine Automobile Club (ACA) and the Argentine Touring Club (TCA), the two principal automobile clubs in the country and                     the largest ones in Latin America during the first half of the twentieth century. It argues that the ACA and TCA had a decisive                     influence during the 1920s in diagnosing and listing possible solutions to road and tourism challenges, and providing reference                     points for most of the road and tourism policies in the following decades. At the same time, both clubs actively helped to                     create a national network of roads through their participation in the planning agencies and made the new roadways accessible                     by signposting them and by providing petrol stations. Not least they formed and spread the new practices of road culture and                     automobility and, by organising sporting events, tours and rally drives and printing travel guides and maps, they contributed                     to the symbolic construction of the roads.","palabras_clave":"AUTOMOBILE CLUBS|ROADS|STATE|PUBLIC POLICY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":829,"idioma_id":5,"titulo":"Investigación en el campo del arte, presentación de un caso y \tniveles de anclaje.","resumen":"INVESTIGACIÓN EN EL CAMPO DEL ARTE.   PRESENTACIÓN DE UN CASO Y NIVELES DE ANCLAJE.      RESUMEN  Muchas veces en la investigación en el campo del arte los términos son ambiguos si no se los precisa. Retomamos la distinción entre cuestiones ontológicas (tipos de objetos de investigación), epistemológicas (conocimientos producidos) y metodológicas propiamente dichas (discusiones en torno de los vínculos con las ciencias sociales). A su vez distinguimos la investigación en el campo del arte, de la investigación artística (IENA) propiamente dicha, reservando para esta última los sentidos de un tipo de indagación estética creativa, en la incorporación de nuevos lenguajes y modalidades de obras.   El trabajo busca ser una excusa para que, presentando una exploración en curso dentro de la casa\/museo El Fogón de los Arrieros, podamos actualizar brevemente un debate sobre dos concepciones vinculadas: la IENA y la investigación sobre objetos artísticos. Además de arriesgar una propuesta de abordaje con matriz de datos para estratificar los niveles de análisis, dejando interrogantes para sucesivos planteos que contengan los rasgos propios de la pesquisa teórica y práctica sobre artes.","palabras_clave":"METODOLOGÍA|ARTES|FOGÓN|INVESTIGACIÓN|MATRIZ"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":830,"idioma_id":5,"titulo":"Introducción al Dossier 'A cien años de la Primera Guerra Mundial: una aproximación a su impacto en la Argentina'","resumen":"        La Primera Guerra Mundial tuvo una  indudable centralidad para sus contemporáneos de la Argentina. La contienda fue  vivenciada de manera muy intensa por la sociedad, que históricamente cultivaba  múltiples lazos culturales, económicos y demográficos con el Viejo Continente.  Esa sociedad cosmopolita, que reproducía en pequeña escala los bandos que se  enfrentaban en las trincheras europeas,&nbsp;  protagonizó una activa militancia cultural y política en torno de la  contienda.       En  la última década se ha progresado mucho en la reconstrucción del impacto de este  acontecimiento en la historia de la Argentina. Los trabajos reunidos en este dossier  constituyen una muestra de los aportes historiográficos recientes, que han  contribuido a disipar la nebulosa que rodeaba a esta problemática. &nbsp;   ","palabras_clave":"PRIMERA GUERRA MUNDIAL|INTELECTUALES|PRENSA|INMIGRANTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":831,"idioma_id":5,"titulo":"Movilización y propaganda durante la Primera Guerra Mundial. Entrevista a Troy R. E. Paddock","resumen":"La  Primera Guerra Mundial marcó un clivaje crucial en la historia contemporánea y  el inicio de una nueva fase signada por la movilización masiva de la sociedad y  por las polarizaciones ideológicas. Definida a menudo como una 'guerra total',  atravesó transversalmente a las naciones beligerantes y difuminó las fronteras  entre el frente de batalla y el frente interno. En las últimas décadas la Gran  Guerra ha sido objeto de una profunda renovación historiográfica que ha  arrojado nueva luz sobre dimensiones de análisis hasta entonces descuidadas.  Entre ellas merece destacarse el estudio de la propaganda de guerra, que ha  sido radicalmente reenfocada y reinterpretada. Para aproximarnos a esta  temática hemos entrevistado a Troy Paddock, un especialista en la materia que  ha contribuido decisivamente al desarrollo de esta perspectiva de análisis  reciente y novedosa.&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ","palabras_clave":"PRIMERA GUERRA MUNDIAL|PROPAGANDA|ALIADOS|IMPERIOS CENTRALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":832,"idioma_id":4,"titulo":"Metabolism of isochroman by biotransformation with filamentous fungi","resumen":"Isochroman  and their derivatives are substances of natural origin, such as compounds  obtained by the cultivation of microorganism and of plant origin. The  increasing studies during the last 20 years indicated the undoubted value of  the isochroman ring as the structural basis of a large number of biologically  active compounds. In the present work we present the methods used to catalyze  the biotransformation of isochroman using two experimental conditions: growing  and resting cells with strains of Aspergillus  flavus, A. terreus, A. niger and Cunninghamella spp. Three biotransformations products from the  selective oxidation of isochroman at C-1 were purified from the bio-reaction  media and their structures were elucidated by spectroscopic methods and mass  spectrometry. The latter technique coupled to gas chromatography was used to  analyze the time course of the biotransformation. The use of cytochrome P450  enzyme inhibitors, as well as working under poor oxygen conditions allowed us  both to inquire about the type of enzymes involved in the process. The results  also establish that A. niger was the  best biocatalyst for the diversity of compounds obtained. The biotransformation  with A. flavus showed the presence of  two compounds from substrate, whereas other filamentous fungi gave a high yield  of a particular metabolite. Finally, these results provide tools to handle  bio-reaction methods and particularly to choose the proper incubation times to  obtain better yields of a particular metabolite. Biocatalytic development  described here can serve as a starting point to optimize conditions so as to  obtain isochroman derivatives through such environmentally friendly procedures.  ","palabras_clave":"METABOLISM|ISOCHROMAN|BIOTRANSFORMATION|FILAMENTOUS FUNGI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":834,"idioma_id":5,"titulo":"Ciudadanos extranjeros","resumen":"Los derechos políticos de los extranjeros son fundamentales porque las sociedades democráticas, eventualmente, siempre descargarán su ira e impotencia sobre esta figura. Una sociedad democrática no extiende los derechos políticos a los extranjeros porque es democrática, sino porque eventualmente puede no serlo. El canto de las sirenas, es esa sed irracional y pulsional que empuja a las sociedades (especialmente en tiempos de crisis) a la búsqueda de carneros sacrificiales, el mástil son los derechos políticos. Esos derechos que deben extenderse, no porque existe un sujeto político que los reclame, sino justamente porque tal sujeto político no existe.","palabras_clave":"ciudadanía|extranjería|derechos políticos|voto extranjero"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":835,"idioma_id":5,"titulo":"La revolución minera asturiana de 1934 en Melania Jacoby, de Susana Pérez Alonso: un conflicto individual de proyecciones universales","resumen":"Ha venido surgiendo en la literatura española de las últimas décadas una serie de relatos que intentan, con mayor o menor afán revisionista, la reinterpretación de los hechos históricos recientes, en especial, los referidos a la Guerra Civil, la crisis de Posguerra y el Exilio. Así lo atestiguan novelas como La voz dormida de Dulce Chacón (2002), La Desbandá de Luis Melero (2005), El corazón helado de Almudena Grandes (2007), Los años del miedo de Juan Eslava Galán (2008), entre otras tantas.   En este marco, la escritora asturiana Susana Pérez Alonso inscribe su última novela, Melania Jacoby (2010), comienzo de una trilogía que abarcará la revolución minera asturiana de 1934, la guerra civil española y el exilio asturiano.   La novela está articulada en base a dos ejes centrales: la historia de una mujer adelantada a su época, que cuestiona radicalmente el orden impuesto por el poder masculino, y la irrupción del conflicto minero de 1934, que dibujará desde sus márgenes un mapa de recorridos por la situación social, política y económica de la Asturias previa a la Guerra Civil. Progresivamente ese primer eje irá integrándose en el segundo y adquirirá un relieve peculiar.   Pérez Alonso concede a la cuestión minera una relevancia ambigua: la de indagar en el ser asturiano, su grito de rebeldía social y la huella ostensible que ha impreso en la historia de su país, al mismo tiempo que la de erigirse como una metáfora universal de dos fuerzas en pugna: la indómita Naturaleza (representada tanto por el mar y las praderías, como por la mina) y el afán del hombre de imponerse sobre ella, intentando doblegarla a su servicio (en las figuras de la burguesía asturiana y el incipiente poder franquista).   Es el propósito de este ensayo analizar cómo la figura de Melania Jacoby, la mujer transgresora del orden hegemónico, tanto de clase como de género, se constituye en un punto de articulación y de diálogo entre las citadas fuerzas antagónicas y configura un espacio intersticial, un borde, donde resisten los marginales (las mujeres, los perseguidos, por pobres).","palabras_clave":"GUERRA CIVIL ESPAÑOLA|IDENTIDAD|EXILIO|NARRATIVA ESPAÑOLA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":836,"idioma_id":5,"titulo":"Nicolás Casullo: La memoria de la derrota desde el exilio","resumen":"Dentro de la narrativa y del ensayo del exilio, destaca la obra del intelectual argentino exiliado en México, Nicolás Casullo, cuya producción puede pensarse en relación a una propuesta vertebradora: la de flexibilizar las distancias entre el pasado y el presente, no abordar los hechos pasados como clausurados, rescatar del olvido datos, interpretaciones, ideas que han resultado altamente significativas y determinantes en su momento y, sobre todo, fundamentales para pensar y examinar la realidad argentina, su historia, evitando así discursos dogmáticos y totalizaciones de sentido.","palabras_clave":"EXILIO|DERROTA|IDENTIDAD|MEMORIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":837,"idioma_id":4,"titulo":"A note on someone (else). An island repair solution and its competitors","resumen":"It is shown that sluicing sentences involving the unexpected absence of 'else' modification for the wh-remnant (Barros 2012) are best analyzed as instances of island repair under ellipsis, specifically, as repair of the Coordinate Structure Constraint. Two alternative analyses are discussed, namely, Barros´ solution in terms of a predicative strategy and a potential mutual entailment approach à la Merchant 2001, and it is shown that they have to face serious empirical challenges.","palabras_clave":"Sluicing|Island repair|Spanish|DOM|ELSE-modification"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":839,"idioma_id":4,"titulo":"Archaeological evidence for hunter-gatherers mobility and diet changes during eighteen and nineteen centuries in the central Patagonian Atlantic coast","resumen":"The information discussed supports the less intensive use of these littoral sectors and their resources during equestrian times. The more probable explanations would be the mobility changes derived from the horse ecology and requirements (especially water), and the reduction in the acquisition costs of their prey. In the future we expect to explore these hypotheses through more and better archaeological evidence.","palabras_clave":"EVIDENCES|HUNTER-GATHERERS|MOBILITY|DIET|PATAGONIAN COAST|EIGHTEEN AND NINETEEN CENTURIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":840,"idioma_id":5,"titulo":"LA INTERNACIONALIZACIÓN ACELERADA DE PyMEs DE SOFTWARE EN SANTA FE","resumen":"Este trabajo analiza la influencia de las redes y de l conocimiento sobre las oportunidades de negocios en mercados externos de las empresas del sector de software y servicios informáticos de Argentina de acuerdo a los postulados del modelo de internacionalización acelerada de Oviatt y McDougall y considerando que participan de una economía emergente donde las dimensiones difieren de las economías desarrolladas. La investigación se basa en un trabajo de campo realizado sobre 14 empresas del sector localizadas en la provincia de Santa Fe, Argentina, que reciben estímulos gubernamentales y de centros de estudios similares por lo que constituye una muestra homogénea. Las conclusiones revelan que los ?brokers? de redes locales y las vinculaciones que existen con clientes en los mercados de destino son las principales fuerzas que ayudaron a estas PyMEs del sector a internacionalizarse aceleradamente.","palabras_clave":"PYMES DE SOFTWARE|INTERNACIONALIZACIÓN ACELERADA|REDES|CONOCIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":841,"idioma_id":5,"titulo":"Apelar a la memoria del terrorismo de Estado y el Holocausto como forma de argentinizar la propia experiencia: los usos del pasado en los casos de organizaciones judías y palestinas en Argentina","resumen":"Como señala Bernardo Sorj, frente al ocaso de los grandes movimientos de transformación del siglo XX, la ?victimización que reclama una reparación pasó a ser una nueva matriz discursiva de las identidades colectivas?.  El presente trabajo buscará establecer el modo en que diversas organizaciones representativas del colectivo judío y palestino apelan a la experiencia del terrorismo de Estado para hacer visibles sus propias experiencias y demandas en el espacio público nacional. En el caso de los judíos, el ensayo se concentrará en las estrategias desarrolladas por el Centro de Estudios Sociales de la Delegación de Asociaciones Israelitas de Argentina (CES-DAIA) para emparentar la experiencia de los judíos como víctimas especiales del aparato represivo durante la última dictadura militar y homologar la experiencia argentina con la de los judíos durante el nazismo. En el caso de los palestinos, se analizarán diversos testimonios y convocatorias realizadas por la Federación de Entidades Palestino-Argentinas que apelando a la experiencia del terrorismo de Estado en nuestro país buscan emparentarla con los modos en que el Estado israelí despliega sus modos de dominación en Israel-Palestina.El trabajo buscará comprender los modos a través de los cuales diversos agentes apelan a encuadrar sus memorias para legitimar sus posiciones en el espacio público contemporáneo.","palabras_clave":"Memoria|Argentina|Israel|Palestina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":842,"idioma_id":4,"titulo":"Isolation of Leptospira spp. from a man living in a rural area of the Municipality of Cruz Alta, RS, Brazil","resumen":"The aim of this study wasto describe the isolation of apathogenic strain of Leptospira interrogans from the urine sampleof a male human living in the rural area of the County of CruzAlta, Rio Grande do Sul. An aliquot of each urine sample was sownin a Fletcher and Ellinghausen - McCullough - Johnson - Harris(EMJH) media. Samples in which there was growth of spirocheteswere sent to the Leptospirosis Laboratory of the Institute ofPathobiology in the National Institute of Agricultural Technology,Buenos Aires, Argentina and were typified by the Multiple Locus ofVariable Number Tandem Repeat technique (MLVA). Leptospirainterrogans serovar Copenhageni strain Fiocruz L1-130 wasisolated, and this is a very important finding that serves as awarning to characterize risk situation of leptospirosis epidemicby a pathogenic strain. Health professionals need to be morecommitted to the primary health care in Brazil and routinely applyactions of preventive medicine in rural communities in order toget succes","palabras_clave":"HUMAN LEPTOSPIROSIS |ISOLATION|MLVA|FARM|BRAZIL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":843,"idioma_id":5,"titulo":"La comprensión referencial temprana. Aprendiendo palabras a través de imágenes con distinto nivel de iconicismo","resumen":"El desarrollo de la comprensión referencial de imágenes transita un largo camino durante los primeros años de vida. Esta investigación tuvo como objetivo explorar el impacto del iconicismo en la comprensión referencial de imágenes impresas y el aprendizaje de palabras. En 2 estudios se enseñó a una muestra por conveniencia de 34 niños de 30 meses de edad de jardines infantiles de Rosario, Argentina, una palabra nueva aplicada a un objeto desconocido, mediante un libro de imágenes. Se comparó la ejecución infantil en 2 condiciones, fotografías y bocetos, variando el nivel de iconicismo o grado en que la imagen se asemeja al referente. La Prueba Exacta de Fisher reveló que aprendiendo con bocetos la palabra quedaba fuertemente asociada a la imagen, obstaculizando ver el objeto a través de ella, lo que no se observó en los niños que aprendieron la palabra mediante fotografías. Los resultados muestran que la similitud perceptual incide en la comprensión referencial, siendo las imágenes icónicas representaciones más transparentes a edades tempranas. Esto puede tener implicancias en el diseño de libros educativos para niños pequeños.","palabras_clave":"IMAGENES|PALABRAS|COMPRENSION REFERENCIAL|SIMILITUD PERCEPTUAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":844,"idioma_id":4,"titulo":"Experimental study of the effect of blade curvature and aspect ratio on the performance of a rotary-wing decelerator","resumen":"The effects of different blade configurations on a vertically falling rotating blade decelerator (pararotor)are studied. A pararotor model equipped with cambered plate blades with different curvatures was testedin a wind tunnel. The parameters measured were flow velocity, rotation velocity, the drag generated bythe model, and the blade pitch angle. The parameters selected for the analysis of the results were thedrag coefficient of the model and the velocity ratio (ratio between the falling and rotation velocities).These parameters were determined and compared with those obtained for flat-plate blades. Flat-plateblades with different aspect ratios were also tested and analyzed. The results obtained show that thevelocity ratio increases with camber, and the equivalent drag coefficient remains unaltered by camberand aspect ratio variations.","palabras_clave":"Pararotores"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":849,"idioma_id":5,"titulo":"Análisis comparativo entre el Puerto de Mar del Plata,  Argentina y el Río Tweed, Australia. Técnicas de bypass  como estrategia para superar la obstrucción de la deriva  litoral.","resumen":"Las obras de abrigo del Puerto de Mar del Plata obstruyeron el transporte litoral desde su construcción a principios del siglo XX. Por refracción del oleaje, un banco se forma en el acceso al puerto y disminuyen los aportes sedimentarios al norte. Esta situación obliga a dragadosfrecuentes y al repoblamiento artificial de playas, con importantes inversiones económicas. Dichas estrategias fueron meros paliativos y no solucionaron el problema de obstaculización de la deriva costera. Estos problemas de deriva litoral también afectaron la desembocadura del ríoTweed (Nueva Gales del Sur, Australia). Para evitar sus consecuencias se efectivizó una planta de ?bypassing?. Los objetivos de este trabajo son: a) comparar las variables naturales y humanas que influyen en la dinámica litoral y navegabilidad en ambos sitios, y b) analizar y discutirlas técnicas de mejoramiento aplicados en ambas costas. El método de trabajo involucra una revisión cartográfica, la sistematización de datos e información recopilada, la formulación de propuestas y recomendaciones. De la comparación de ambos sitios, se concluye que las estrategias implementadas en la costa australiana respetaron la dinámica costera y aseguraron su sostenibilidad, mejorando la seguridad en la navegación, y la conservación de los hábitats para organismos marinos. En el litoral de Mar del Plata, las técnicas implementadas no dieron los resultados esperados, a pesar de los costos económicos, ambientales y sociales de su puesta en práctica. Las diferencias ameritan que se considere la conveniencia e implementación de la técnica de ?bypassing? en Mar del Plata.-","palabras_clave":"dinamica costera|refulado|Puerto de Mar del Plata|Tweed River|sistema de bypass"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":851,"idioma_id":4,"titulo":"Shaping changes through participatory processes: Local development and renewable energy in rural habitats","resumen":"The socio-technical adequacy processes of technologies, in general, and particularly, renewable energy, require paradigm changes in the way of thinking and acting in the territory. These processes are key, on post, to achieve greater equality, democratic management, quality of life and environmental sustainability, particularly in the rural areas of Northwest Argentina. The article is based on the premise that these changes are socially constructed.  A set of workshops were conducted on purpose to discuss and reach a consensus on conceptual, methodological and practical aspects, associated with the processes of ?technology transfer? and rural development. Participation in the workshops focused on technical stakeholders (researchers, technicians and extension workers), identified as links between new technology and the users thereof. From these shared spaces, the conceptual model of socio-technical adequacy was validated and multiple determinants for the processes were identified and prioritized. Finally, consensual action oriented proposals in the following levels: personal-institutional, inter-institutional and public policy.  This article concludes that the areas of interaction and collective construction are necessary and feasible for implementation. These areas represent real opportunities to increase equity and improve interventions in rural habitats.","palabras_clave":"Technology transfer|Renewable energy|Participation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":852,"idioma_id":4,"titulo":"Application of logistic regression and frequency ratio in the spatial distribution of debris-rockslides: Precordillera of San Juan, Argentina","resumen":"This study employs statistical modeling techniques and geomorphological mapping to analyze the distribution of debris-rockslides in relation to altitude, aspect, slope angle, lithology and distance to lineaments using optical remote sensing techniques with GIS. The study area includes a portion of the Central Precordillera of San Juan around 32S, 69W, where few geomorphological studies have been conducted. A debris-rockslides inventory map was prepared using debris-rockslides locations identified from satellite imageries, a total of 35 debris-rockslides were identified in an area of 288.13 km2 (with a total slide area of 6.36 km2). All of the debris-rockslides were rotational slides, affecting Upper Ordovician and Upper Devonian deposits. The volumes of debris-rockslides were estimated using the sloping local base level technique that allows computing the possible pre-rockslide topography and the bedrock edeposits interface. The relationship between the variables and the slide distributionwas analyzed using the frequency ratio method and logistic regression models. The analytical results show that lithology and slope exert major influences. Lithology is found to be the most important aspect in the study area.","palabras_clave":"Debris-rockslides|Frequency ratio|Logistic regression|Precordillera"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":854,"idioma_id":6,"titulo":"Migrations Boliviennes vers l Argentine : une histoire des absences et des présences","resumen":"L?histoire et la conformation des sociétés et des économies de l?État argentin sont associées de manière irrémédiable aux procès migratoires.  En effet, ce sont les migrants européens ceux qui ont constitué la  majeure partie de la main d??uvre nécessaire  au programme économique  du modèle agro-exportateur mis en place dans le pays à partir du XIXe. Siècle, celui qui permettra d?augmenter de façon exponentielle la population des grandes villes.  En même temps, le XIX siècle constituera le scénario d?élaboration d?un discours positif ? de part des groupes dominants- sur la  figure de l?immigrant, ainsi que des conséquences de sa permanence (Halperin Dongui, 1978) , discours qui  commença à s?effriter durant le XX siècle lorsque quelques étrangers ont été associés à ce qui se montrait comme les grandes questions sociales du temps (les épidémies, les troubles syndicaux, la crise de logements).  Néanmoins les représentations hégémoniques de la société argentine ont gardé un discours épique sur l?émigrant européen et travailleur en le situant dans les origines mêmes de ce qu?on entend par société argentine contemporaine.  En face du formidable nombre d?immigrants d?ascendance européenne, la présence d?une population étrangère  latino-américaine résultait « invisible » jusqu?à la fin du XXe siècle- renforcé par la faiblesse empirique et symbolique des frontières- moment où sa présence est devenue évidente d?une manière stigmatisée et avec intention raciale.   Cet article examinera spécifiquement la question de l?immigration d?origine bolivienne. Si bien ne s?agit-il du courant migratoire plus important du point de vue quantitatif (place occupée par la population d?origine paraguayenne), elle a été construite comme symbole des figures de l?immigration latino-américaine.","palabras_clave":"migraciones bolivianas|argentina|historia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":855,"idioma_id":5,"titulo":"ESTUDIO PALINOLÓGICO DE LA FORMACIÓN LA VETEADA EN SU LOCALIDAD TIPO (PÉRMICO SUPERIOR), SIERRA DE FAMATINA, LA RIOJA, ARGENTINA. GRANOS DE POLEN ESTRIADOS, PLICADOS Y COLPADOS","resumen":"PALYNOLOGICAL STUDY OF LA VETEADA FORMATION AT ITS TYPE LOCALITY (UPPER PERMIAN), FAMATINA RANGE, LA RIOJA PROVINCE, ARGENTINA. STRIATE, PLICATE AND COLPATE POLLEN GRAINS. This is a systematic study of the palynological assemblages recorded in the upper part of the La Veteada Formation (upper La Veteada Association), which constitutes the section of the type locality, La Rioja Province, Argentina. In this contribution, 72 species of striate (monosaccate and bisaccate), plicates and colpate pollen grains are presented. Four new species are described: Meristocorpus veteadensis sp. nov., Lueckisporites biformis sp. nov., Lunatisporites lenticularis sp. nov., and Marsupipollenites costatus sp. nov. and, a new combination, i.e., Striatopodocarpites gopadensis (Bharadwaj and Srivastava) comb. nov is proposed. This palynoflora has a marked dominance of striate pollen grains which have great species diversity of Striatopodocarpites (with 11 species)-Protohaploxypinus (9 species)-Lueckisporites (9 species)-Lunatisporites (8 species) complex, showing scarse participation of the genera Vittatina, Weylandites, Marsupipollenites, Corisaccites, Staurosaccites and Pakhapites, as well as pollen grains referred to Cordaitales (Potonieisporites, Cannanoropollis, Caheniasaccites, Plicatipollenites, Barakarites). It shares taxa recorded in the LW (Argentina), Vc-Lv (Brazil) and IS-AC (Uruguay) biozones. Tables include full taxonomic composition of the microflora of the La Veteada Formation at its type locality, the palynostratigraphic correlation of the Neopaleozoic strata of central Argentina, southern Brazil and Uruguay, and the global previous stratigraphic records of the species recorded and discussed herein. The palynoflora of the upper La Veteada Formation is referred to the Late Permian (Lopingian) based on the stratigraphic range of all the recognized species. Consequently, it is considered the youngest Permian palynoflora recorded hitherto in Argentina and South America.","palabras_clave":"Granos de Polen|Pérmico Superior|Formación La Veteada|La Rioja|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":856,"idioma_id":5,"titulo":"El registro zooarqueológico del Parque Nacional Monte león (Santa Cruz, Argentina): una perspectiva desde el sitio Cabeza de León 1","resumen":"El sitio arqueológico Cabeza de León 1 es una referencia en el Parque Nacional Monte León debido a la abundancia y variedad de materiales que lo caracterizan. La información disponible hasta el presente se basó en observaciones del registro superficial, las cuales constituyeron una primera aproximación a su riqueza arqueológica así como una evaluación de los impactos producidos por la depredación de la que fue objeto por parte de coleccionistas. En este trabajo se estudia el conjunto zooarqueológico recuperado en estratigrafía con la doble finalidad de presentar un marco de análisis zooarqueológico para el depósito y una evaluación de su correspondencia con la información de superficie previamente generada para el mismo y para el área en general. Los resultados indican que el depósito se habría originado por una depositación abundante, pero diferida en el tiempo. Las propiedades tafonómicas que lo caracterizan son semejantes a otros depósitos costeros que tampoco están asociados a grandes concentraciones de moluscos. Los restos de mamíferos presentan modificaciones óseas de origen antrópico, entre las que dominan las huellas de corte y en segundo lugar las de machacado. El análisis de esta evidencia permite sostener que los restos fueron descartados como resultado, principalmente, de actividades de desmembramiento y descarne.","palabras_clave":"Parque Nacional Monte León|Zooarqueología|Cazadores Recolectores|Patagonia Meridional"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":857,"idioma_id":4,"titulo":"In vitro inhibition of incompatible pollen tubes in Nicotiana alata involves the uncoupling of the F-actin cytoskeleton and the endomembrane trafficking system","resumen":"In the S-RNase-based self-incompatibility system, subcellular events occurring in the apical region of incompatible pollen tubes during the pollen rejection process are poorly understood. F-actin dynamics and endomembrane trafficking are crucial for polar growth, which is temporally and spatially controlled in the tip region of pollen tubes. Thus, we developed a simple in vitro assay to study the changes in the F-actin cytoskeleton and the endomembrane system at the apical region of incompatible pollen tubes in Nicotiana alata. Growth but not germination of pollen tubes of S c10 -, S 70 -, and S 75 -haplotypes was selectively inhibited by style extracts carrying the same haplotypes. Pollen F-actin cytoskeleton and endomembrane system, visualized by fluorescent markers, were normal during the initial 60 min of pollen culture in the presence of compatible and incompatible style extracts. Additional culture resulted in complete growth arrest and critical alterations in the integrity of the F-actin cytoskeleton and the endomembrane system of incompatible pollen tubes. The F-actin ring and the V-shaped zone disappeared from the apical region, while distorted F-actin cables and progressive formation of membrane aggregates evolved in the subapical region and the shank. The vacuolar network of incompatible pollen tubes invaded the tip region, but vacuolar membrane integrity remained mostly unaffected. The polar growth machinery of incompatible pollen tubes was uncoupled, as evidenced by the severe disruption of colocalization between the F-actin cytoskeleton and the endomembrane compartments. A model of pollen rejection integrating the main subcellular events occurring in incompatible pollen is discussed.","palabras_clave":"Endomembrane system|F-actin|Nicotiana alata|Polar growth|Self-incompatibility"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":858,"idioma_id":5,"titulo":"Travesías de investigación. Varias tesis sobre creatividad.","resumen":"Me propongo comentar una investigación, La creatividad en personas comunes. Potencialidades en contextos cotidianos, que ha sido presentada en 2011 como Tesis en el marco de la Carrera de Doctorado en Psicología de la Universidad Nacional de San Luis. Intento mostrar recorridos y travesías metodológicas en la búsqueda de una Tesis, un escrito académico, sobre creatividad. Sin embargo, múltiples tesis, argumentaciones, sobre los procesos creativos y las formas de estudiarlos fluyen en un escrito indisciplinado sobre un tema netamente indisciplinado. El título del artículo anticipa el tratamiento de aspectos dinámicos de la investigación, es decir travesías y también el desarrollo de tesis, en singular, como escrito académico, en plural, como argumentaciones y proposiciones diversas.   Destaco el papel de las preguntas, las estructuras, las decisiones metodológicas y a la escritura científica en las prácticas de investigación. Saber contar las decisiones y las acciones que se han ido desarrollando durante el proceso y las teorías emergentes es indispensable para una buena comprensión de la investigación como práctica social comunicativa. Asimismo es indispensable reflexionar acerca de los fundamentos éticos de nuestras acciones y de los propósitos y valores que orientan nuestra práctica. Las decisiones metodológicas también dependen de los entornos particulares en los que se planifica la investigación y de contextos culturales más amplios donde los conocimientos se construyen y reconstruyen. Deudas pendientes, desafíos y esperanzas cierran el artículo y abren posibilidades infinitas de nuevas tesis y travesías.","palabras_clave":"Creatividad|Investigación |Tesis de Doctorado|Metodología de Investigación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":859,"idioma_id":4,"titulo":"Comparison of nitrogen fertilizer demand for wheat production between humid and semi-arid portions of the Argentinean Pampas using a mass balance approach","resumen":"The Argentinean Pampa is an important grain production region in which nitrogen (N) availability restricts wheat (Triticum aestivum L.) yield. We performed 46 experiments in the Semi-arid Pampa for evaluating soil N supplying capacity using a mass balance approach. The information generated was combined with published results from 58 experiments performed in the Humid Pampa. Average rainfall was 50% lower under semi-arid conditions and soils had half of the clay&nbsp;+&nbsp;silt and total N contents than those of humid environments. Wheat yield under humid scenarios doubled the yield attained under semi-arid ones, and N and rainfall use efficiencies were also higher. A model could be fitted with good performance for estimating N-supplying capacity from mineral and organic soil pools (R2&nbsp;=&nbsp;0.53?0.93), absorbed N (R2&nbsp;=&nbsp;0.70) and yield (R2&nbsp;=&nbsp;0.57). This methodology can be used for estimating fertilizer needs under defined climate- and site-specific scenarios. For the average yields, rainfall and soil conditions of the experimental networks, targeted N supply (soil mineral&nbsp;+&nbsp;fertilizer N) was estimated as 160&nbsp;kg&nbsp;N&nbsp;ha&#8722;1 in the Humid Pampa and 50&nbsp;kg&nbsp;N&nbsp;ha&#8722;1 in the Semi-arid Pampa. Current N rates applied by farmers need to be increased under humid conditions and overfertilization occurs under semi-arid ones.","palabras_clave":"NITROGEN|MASS BALANCE|WHEAT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":860,"idioma_id":4,"titulo":"Suitable multicomponent organic synthesis using heteropolycompounds as catalysts","resumen":"Nowadays, scientists need to work with non-contaminating technologies. Some approaches include the use of multicomponent reactions (MCRs), and solid and reusable catalysts. Through MCRs it is possible to work without isolating intermediate products, so the use of auxiliary solvents is minimized.  Furthermore, catalysis by heteropolycompounds is a field of increasing importance worldwide. Heteropolycompounds are effective, reusable and stable solid catalysts that have intrinsic multifunctionality: they can be designed in order to enhance their redox or superacidic properties by varying the atoms in their formula.  The present review presents recent advances in the synthesis of organic compounds through multicomponent reactions by using heteropolycompounds as catalysts. Some of these compounds are: dihydropyrimidinones, quinazolinones, naphthol derivatives, pyridines, xanthenones, azabicyclo[2.2.2]octan-5-ones, dispiroheterocycles, imidazoles, spirofused heterocycles, and 1,4-dihydropyridines.","palabras_clave":"GREEN CHEMISTRY|ORGANIC SYNTHESIS|HETEROCYCLES|MULTICOMPONENT REACTION|HETEROPOLYCOMPOUNDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":861,"idioma_id":5,"titulo":"ANÁLISIS DE LA PROGENIE DE INDIVIDUOS PRODUCTORES Y NO PRODUCTORES DE GAMETOS MASCULINOS NO REDUCIDOS DE TURNERA SIDOIDES L. (PASSIFLORACEAE)'.","resumen":"La unión de gametos 2n ha tenido un importante papel en el origen de los poliploides de Turnera sidoides. Sin embargo, como en este complejo la tasa de formación de neopoliploides es baja, el establecimiento de los mismos constituiría una etapa crítica. Considerando que la dinámica evolutiva de los poliploides depende en gran medida de la frecuencia de producción de gametos 2n, dicha etapa podría ser superada si la capacidad de los diploides de producir estos gametos es transmitida a la descendencia. En este marco, se analizó la progenie de cruzamientos experimentales entre productores y no productores de gametos masculinos 2n de T. sidoides. Los resultados mostraron que la capacidad de producir gametos 2n estaría regulada por un gen con dos alelos, uno de ellos completamente dominante sobre el otro, siendo el carácter recesivo. La variación en la frecuencia de los gametos 2n y 4n sería atribuida a diferencias en la expresión génica. La posibilidad de transmitir la capacidad de producir gametos masculinos 2n a la progenie, contribuiría a aumentar tanto las tasas de formación como la probabilidad de que ocurran cruzamientos entre individuos productores de estos gametos, favoreciendo el establecimiento de neopoliploides en las poblaciones diploides del T. sidoides.","palabras_clave":"TURNERA SIDOIDES|GAMETOS MASCULINOS NO REDUCIDOS|POLIPLOIDIA|CRUZAMIENTOS EXPERIMENTALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":862,"idioma_id":4,"titulo":"Molecular phylogenetics of tribe Eudemeae (Brassicaceae) and implications for its morphology and distribution","resumen":"Tribe Eudemeae comprises a morphologically heterogeneous group of genera distributed along the Andesof South America from Colombia southward into southern Chile and Argentina. The tribe currentlyincludes seven genera: Aschersoniodoxa, Brayopsis, Dactylocardamum, Delpinophytum, Eudema, Onuris,and Xerodraba, and exhibits a wide morphological diversification in growth habit, inflorescences, andfruits. However, little is known about the phylogenetic relationships and evolution of the tribe. We presenthere a molecular phylogeny of representative sampling of all genera, utilizing sequence data from thenuclear ribosomal ITS region and chloroplast regions trnL-F, trnH-psbA, and rps16. Additionally, climaticniches of the tribe and its main lineages, along with the evolution of diagnostic morphological characters,were studied. All analyses confirmed the monophyly of Eudemeae, with the exception of Delpinophytumthat was included with genera of the lineage I of Brassicaceae. Eudemeae is divided into two main lineagesdifferentiated by their geographical distribution and climatic niche: the primarily north-centralAndean lineage included Aschersoniodoxa, Brayopsis, Dactylocardamum, and Eudema, and the Patagonianand southern Andean lineage included Onuris and Xerodraba. Finally, ancestral-state reconstructions inthe tribe generally reveal multiple and independent gains or losses of diagnostic morphological characters,such as growth form, inflorescence reduction, and fruit type. Relevant taxonomic implications stemmingfrom the results are also discussed.","palabras_clave":"Andes|Brassicaceae|Eudemeae|Morphology|South America|Phylogeny"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":863,"idioma_id":5,"titulo":"Barroco, modernismo, neobarroco","resumen":"Desde que Rubén Darío sacó Prosas profanas, la crítica identificó el Modernismo con el Barroco sobre todo a causa de la presencia en ese volumen del tríptico de sonetos ?Trébol?, en el que el nicaragüense hace un homenaje cruzado a Góngora y Velázquez. En este trabajo me propongo explorar este problema estableciendo una comparación entre las dos poéticas mediante los ejes generales de política, religión y lenguaje.","palabras_clave":"BARROCO|MODERNISMO|NEOBARROCO|AMÉRICA LATINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":864,"idioma_id":5,"titulo":"Mestizaje, castas y razas en la literatura de viajes. De Félix de Azara a Alcide d?Orbigny (Río de la Plata, 1780-1830).","resumen":"Dentro del contexto exploratorio y expansionista europeo de fines del siglo XVIII y comienzos del XIX, cobraron especial relevancia los viajes que permitían, entre otras cosas, recabar datos para sumar en la línea de la Historia natural. A partir de las observaciones de Félix de Azara y Alcide d?Orbigny sobre las poblaciones del Paraguay y Río de la Plata, interesa contrastar ambas etapas y narrativas clasificatorias, para desarticular en torno a ellas objetivos políticos subyacentes, paradigmas científicos asociados y esquemas de pensamiento que contribuyeron en la consolidación de divisiones étnico\/raciales.","palabras_clave":"Félix de Azara|Alcide d?Orbigny |Castas |Razas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":865,"idioma_id":5,"titulo":"DETECCIÓN DE LA PRODUCCIÓN DE OCRATOXINA A POR CEPAS DE ASPERGILLUS SECCIÓN ?NIGRI? AISLADAS DE YERBA MATE COMPUESTA.","resumen":"La Ocratoxina A (OTA) es una micotoxina nefrotoxica, inmunosupresora, teratogénica y potencialmente cancerigena producida por especies de los géneros Aspergillus y Penicillium. Losmiembros del genero Aspergillus seccion Nigri son importantes productores de OTA y forman parte de la micobiota de diversos alimentos. El objetivo del presente trabajo fue investigar la incidencia del genero Aspergillus en yerba mate compuesta y determinar la capacidad ocratoxicogenica de las cepas de Aspergillus seccion nigri. Se aislaron 2072 cepas de Aspergillus a partir de 41 muestras de yerba mate compuesta, de las cuales 1635 pertenecieron a la seccion Nigri. Para la deteccion de la capacidad ocratoxicogenica, las cepas se cultivaron en agar Czapeck extracto de levadura a 25 °C durante 7 dias y la toxina se detecto mediante cromatografia en capa delgada, bajo luz UV. De las 1635 cepas estudiadas, 40 % correspondieron a A. japonicus var japonicus, 28 % a A. japonicus var aculeatus, 16% A. niger var. niger, 12 % A. foetidus, 2% A Carbonarius y 2% A. niger var. awamori. Menos del 1 % de las cepas mostraron capacidad ocratoxigénica in vitro, siendo A. japonicus var aculeatus la unica especie productora de OTA.","palabras_clave":"ILEX PARAGUARIENSIS|HONGOS FILAMENTOSOS|MOHOS |MICOTOXINAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":866,"idioma_id":5,"titulo":"?Sublimación y creatividad en la clínica grupal de niños con problemas de simbolización?","resumen":"Los niños con problemas de simbolización presentan significativas dificultades para relacionarse con los objetos sociales y de conocimiento de una manera ágil, creativa y autónoma. Sus producciones simbólicas (narraciones, dibujos, lecturas y escritos) presentan indicios singulares de estas formas precarias de simbolización, entre las que prevalecen los aprendizajes mecanicistas, sobreadaptativos, sin sentido singular, o bien disrupciones afectivas que dificultan la organización psíquica necesaria para la organización de producciones transmisibles y compartibles. Este artículo se plantea revisar los textos metapsicológicos freudianos a la luz de nuevos desarrollos del psicoanálisis contemporáneo, para rastrear en ellos conceptos como el de imaginación , sublimación, transicionalidad, entre otros, que posibiliten profundizar en la comprensión teórico clínica de la creatividad y sus problemáticas manifiestas en las dificultades de aprendizaje de niños en edad escolar.Para esto, las autoras articulan las nociones teóricas propuestas con viñetas clínicas extraídas de la experiencia terapéutica con grupos de sujetos con problemas de aprendizaje consultantes al Servicio de Psicopedagogía Clínica en la Facultad de Psicología, UBA.","palabras_clave":"sublimación |creatividad|clínica psicopedagógica grupal|problemas de simbolización"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":869,"idioma_id":5,"titulo":"Nuevos datos de isótopos estables del C y N para el Sudeste de la Región Pampeana. ).","resumen":"..","palabras_clave":"ISOTOPOS ESTABLES|ARQUEOLOGIA|REGION PAMPEANA|.."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":870,"idioma_id":5,"titulo":"¿Quién es excombatiente?  El acampe de los 'movilizados' de Malvinas en la ciudad de Corrientes (2006 - 2010)","resumen":"El siguiente estudio se centra en el problema identitario de los llamados 'movilizados' de la guerra de Malvinas, a partir de un análisis del acampe realizado por la Asociación 'Veteranos del Teatro de Operaciones del Atlántico Sur Clase 1962' de la ciudad de Corrientes entre 2006 y 2010. Creemos que este proceso hecha luz sobre tres aspectos que cruzan a la Cuestión Malvinas: la figura del 'reconocimiento' como un campo de disputas, la relación entre acción política e identidad, y por último el papel del Estado como 'reconocedor' desde la promulgación de leyes.","palabras_clave":"movilizados|excombatientes|veteranos|Malvinas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":872,"idioma_id":4,"titulo":"Latitudinal gradient of nestedness and its potential drivers in stream detritivores","resumen":"Understanding what mechanisms shape the diversity and composition of biological assemblages across broad-scale gradients is central to ecology. Litter-consuming detritivorous invertebrates in streams show an unusual diversity gradient, with a-diversity increasing towards high latitudes but no trend in g-diversity. We hypothesized this pattern to be related to shifts in nestedness and several ecological processes shaping their assemblages (dispersal, environmental filtering and competition). We tested this hypothesis, using a global dataset, by examining latitudinal trends in nestedness and several indicators of the above processes along the latitudinal gradient. Our results suggest that strong environmental filtering and low dispersal in the tropics lead to often species-poor local detritivore assemblages, nested in richer regional assemblages. At higher latitudes, dispersal becomes stronger, disrupting the nested assemblage structure and resulting in local assemblages that are generally more species-rich and non-nested subsets of the regional species pools. Our results provide  evidence that mechanisms underlying assemblage composition and diversity of stream litter-consuming detritivores shift across latitudes, and provide an explanation for their unusual pattern of increasing a-diversity with latitude. When we repeated these analyses for whole invertebrate assemblages of leaf litter and for abundant taxa showing reverse or no diversity gradients we found no latitudinal patterns, suggesting that function-based rather than taxon-based analyses of assemblages may help elucidate the mechanisms behind diversity gradients.","palabras_clave":"stream detritivores|latitudinal gradients|spatial nestedness|leaf litter dynamics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":873,"idioma_id":4,"titulo":"Sequence conservation of small RNAs detected by RNA-seq in different Pseudomonas species.","resumen":"RNA sequencing (RNA-seq) has revealed several hundreds of previously undetected small RNAs (sRNAs) in all bacterial species investigated, including strains of Pseudomonas aeruginosa, Pseudomonas putida, and Pseudomonas syringae. Nonetheless, only little is known about the extent of conservation of expressed sRNAs across strains and species. In this study, we have used RNA-seq to identify sRNAs in Pseudomonas putida DOT-T1E and Pseudomonas extremaustralis 14-3b. This is the first strain of P. extremaustralis and the second strain of P. putida to have their transcriptomes analyzed for sRNAs, and we identify the presence of around 150 novel sRNAs in each strain. Furthermore, we provide a comparison based on sequence conservation of all the sRNAs detected by RNA-seq in the Pseudomonas species investigated so far. Our results show that the extent of sRNA conservation across different species is very limited. In addition, when comparing the sRNAs expressed in different strains of the same species we observe that numerous sRNAs exhibit a strain-specific expression pattern. These results support the idea that the evolution of most bacterial sRNAs is rapid, which limits the extent of both inter- and intra-species conservation.","palabras_clave":"PSEUDOMONAS|SMALL RNA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":874,"idioma_id":5,"titulo":"El estado de excepción a escala comparada. Notas a partir de los casos argentino, chileno y uruguayo","resumen":"El artículo propone  abordar el recurso al estado de excepción como instrumento de gobiernos  democráticos en el Cono Sur durante la década de 1950 entendiéndolo como una  situación política que habilita a los poderes instituidos a suspender total o  parcialmente el estado de derecho en casos considerados amenazas al orden  interno. Ello genera, a partir de su entrada en vigencia, un marco político de  acción en el que las medidas de los gobernantes quedan legitimadas por una  fuerza que está a la vez dentro y fuera del orden legal y que habilita al  tratamiento de los actores entendidos como peligrosos como enemigos de la  organización política. Para ello,  realizaremos un abordaje histórico comparado del recurso al estado de excepción  en Argentina, Chile y Uruguay tomando tres coyunturas como ejemplos  representativos de cada caso. Mediante el enfoque comparativo realizaremos un  ejercicio de desnaturalización de los tres casos nacionales para advertir cómo  ciertas lógicas y prácticas políticas propias y específicas de cada sociedad  están lejos de ser naturales u obvias y requieren explicación. Además,  aspiramos a detectar rasgos comunes de los tres casos que permitan identificar,  por un lado, algunos aspectos políticos que puedan ser entendidos como  característicos del recurso al estado de excepción y, por el otro, dar cuenta  de aspectos históricos y epocales propios y más generales del período  seleccionado.","palabras_clave":"ESTADO DE EXCEPCIÓN|ARGENTINA|URUGUAY|CHILE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":875,"idioma_id":5,"titulo":"?ESTA PUEDE SER NUESTRA ÚLTIMA OPORTUNIDAD?: CLARÍN Y EL GOLPE DE ESTADO DEL 28 DE JUNIO DE 1966","resumen":"el texto propone una revisión y análisis del comportamiento del diario Clarín frente al golpe de Estado que llevó a la presidencia al general Juan Carlos Onganía el 28 de junio de 1966, procurando mostrar tanto su posición frente al gobierno derrocado como frente a la nueva realidad política, caracterizada por el intento de creación de una nueva legitimidad, distinta de la establecida por un régimen democrático.","palabras_clave":"Clarin|Golpe de Estado|dictadura militar|1966"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":877,"idioma_id":5,"titulo":"Primer registro de Gynaikothrips ficorum (Thysanoptera, Phlaeothripidae) sobre Ficus benjamina L. (Urticales: Moraceae) en la provincia de Santa Fe, Argentina","resumen":"Casi todas las especies de Thysanoptera que inducen agallas en las plantas están incluidas en  Phlaeothripinae (Phlaeothripidae), uno de los grupos más evolucionados del orden (Mound & Morris, 2005). Las agallas son producidas por  la alimentación  de los trips pero el estímulo que induce la actividad meristemática en las células vegetales que rodean a las que el trips ha eliminado al alimentarse sigue siendo desconocida (Mound & Kranz, 1997).  Ananthakrishnan y Ramann (1989) estudiaron las agallas producidas por trips clasificándolas en sencillas y complejas. En las primeras se incluyen las hojas plegadas y enrolladas  y en las segundas, agallas en forma de roseta, bolsas y ampollas.  Entre las plantas más estudiadas por presentar trips galígenos se encuentra Ficus (Moraceae). Las agallas simples son estimuladas por la alimentación de Gynaikothrips Zimmermann sobre las hojas lo que ocasiona  el pliegue adaxial a lo largo de la nervadura central. El desarrollo de las mismas y su anatomía fueron estudiadas detalladamente por De Souza et al., 2000; Retana-Salazar, 2006; Retana-Salazar & Sánchez-Chacón, 2009 y Desley & Walter, 2009).","palabras_clave":"Plantas ornamentales|Trips|Distribución en Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":879,"idioma_id":5,"titulo":"La inseguridad en las campañas electorales latinoamericanas. El caso del PRO en la Ciudad de Buenos Aires (2007-2011)","resumen":"A partir de 2008, el delito se convirtió en el principal problema social para los ciudadanos latinoamericanos. Como consecuencia, la batalla contra la inseguridad se transformó en uno de los motores de la gubernamentalidad y las campañas electorales se centraron, con frecuencia, en discursos sobre el miedo. El trabajo propone identificar, a partir de un caso de estudio, algunas variables de la comunicación política en el contexto de las sociedades de seguridad. Para ello, se analizaron piezas comunicacionales de las campañas de 2007 y 2011 del actual partido de gobierno en la Ciudad Autónoma de Buenos Aires. ¿Qué tipo de subjetividad se promueve? ¿Cuál es el rol asignado al Estado? ¿Cómo se describe la seguridad? ¿Qué características permiten describir al ciudadano-víctima? El artículo indaga acerca de los modos de interpelación a la ciudadanía, las características de enunciación de la seguridad y la imagen que asume el Estado en momentos electorales.","palabras_clave":"COMUNICACIÓN POLÍTICA|SEGURIDAD|VICTIMIZACIÓN|GOBIERNO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":882,"idioma_id":4,"titulo":"How insect assemblage, flower density and floral visitation rate vary along grazing gradient.","resumen":"            The  introduction of livestock in natural areas is a common disturbance  that affects both plant and pollinator diversity and might affect  their interaction.  Understanding whether livestock affect food  resource for pollinators (i.e. flower abundance) and\/or pollinator  assemblage (i.e. abundance and richness) has important implications  for plant-pollinator interactions and still needs deeper  investigation.              This  study investigated how pollinator communities and flower abundance  determined floral visitation frequency along a grazing gradient,  using seven large paddocks   in Patagonian Monte Desert that varied in livestock densities.  Pollinator visitation frequency was measured in five of the most  abundant native plant species of the region, present in all the  paddocks, but that differed in reproductive strategy ranging from  insect-pollinated self-compatible and self-incompatible to  wind-pollinated.  The influence of livestock density, insect and  flower abundance on visitation frequency was evaluated using  D-separation  hierarchical path models.                  Intermediate  stocking densities showed the highest insect richness and abundance.  Livestock  density showed a negative  quadratic  relationship  with insect richness, hymenopterans being the main insect group in  the region. Flower density decreased with the increase in livestock  density. The  five plant species shared several pollinator species although each  one supported a distinct assemblage.                 The  path model showed that livestock was not directly associated with  pollinator visitation frequency; however, this apparent lack of  association was due to opposite forces acting together. An increase  in livestock density reduced visitation frequency through a decrease  in insect abundance, yet, livestock simultaneously increased  pollinator visitation rate through decreased flower abundance.            5- This study  describes how changes in the density of exotic mammals can affect  pollinator and flower abundance, resulting in contrasting effects on  flower visitation rates with, apparently, neutral net consequences.  This illustrates the complexity of responses of plant-pollinator  interactions to anthropogenic disturbances that alter the ecological  context.       ","palabras_clave":"Arid environment|Hierarchical path models|Insect abundance|Insect richness"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":883,"idioma_id":5,"titulo":"Experiencias políticas de mujeres, relatos de militancia y literatura testimonial durante los años setenta. Textos de Rodolfo Walsh, Francisco Urondo y María Esther Giglio desde una lectura en clave de género.","resumen":"El trabajo se propone, desde una perspectiva inscripta en el cruce entre los estudios culturales y los estudios de género, contribuir al análisis de las narrativas testimoniales publicadas en la década del setenta en el ámbito rioplatense que recuperan experiencias de militancia de mujeres. A tal efecto se aborda un corpus que comprende relatos testimoniales producidos en el período 1968-1976 por los escritores y periodistas argentinos Rodolfo Walsh y Francisco Urondo, y por la periodista uruguaya María Esther Giglio. Se busca analizar esas experiencias de mujeres militantes como una dimensión compleja situada en la tensión entre pasado y presente, entre lo individual y lo colectivo, y vinculada a las condiciones materiales en las que esa experiencia vivida es reflexionada, significada y puesta en el orden del lenguaje.","palabras_clave":"TESTIMONIO|EXPERIENCIA POLÍTICA|MUJERES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":884,"idioma_id":4,"titulo":"Envelopes and reduced-rank regression","resumen":"We incorporate the nascent idea of envelopes (Cook et al., 2010) into reduced-rank regression 16 by proposing a reduced-rank envelope model, which is a hybrid of reduced-rank and envelope 17 regressions. The proposed model has total number of parameters no more than either of reduced-18 rank regression or envelope regression. The resulting estimator is at least as efficient as both 19 existing estimators. The methodology of this paper can be adapted to other envelope models such 20 as partial envelopes (Su & Cook, 2011) and envelopes in predictor space (Cook et al., 2013).","palabras_clave":"Envelope model|Grassmannian|reduced-rank regression"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":886,"idioma_id":4,"titulo":"Molecular characterization of methicillin resistant Staphylococcus aureus clinical isolates in a paediatric hospital.","resumen":"Introduction: Methicillin resistant Staphylococcus aureus (MRSA) is one of the most important agent in nosocomial (HO-MRSA)  and community S. aureus infections (CO-MRSA). The CO-MRSA infection is an emergent entity, associated with  skin infections, cellulite, abscesses and also with severe complications such as sepsis and pneumonia. Several characteristics  differentiate HO-MRSA´s from CO-MRSA: absence of risk factors associated with previous hospitalizations, antibiotics  sensibility to non ß-lactámics, different genotypes from those of the hospital strains, presence of smaller SCCmec type IV or  V, genes that codify toxins as leucocidina of Panton Valentine. Many CO-MRSA like HO-MRSA can circulate in the  community and in the hospitals. Considering the high frequency of these infections in paediatric patients our aim was to do  the molecular characterization of clinical isolates of MRSA in a Paediatric Hospital. Materials and methods: 29 MRSA  isolated from skin and soft parts were studied to determine the structural type of the genetic region that codifies resistance to  meticilin (Staphylococcus Cromosomal Cassette mec) SCCmec. The type of SCCmec was identified by Multiplex PCR  (Oliveira et al, 2002), we differentiated the I, IA, the II, IIIrd, IIIA and the IVth cassettes, mecA gene. PVL´s detection was  done using specific primers (Lina et al, 1999). Results: 28 clinical isolates were positive for the mecA gene, Panton-Valentine  leucocidin and the IVth alelle. Conclusions: we can conclude that there is a high prevalence of CO-MRSA in the paediatric  patients studied. Keywords: molecular characterization, S.aureus meticilin resistant.","palabras_clave":"STAPHYLOCOCCUS |AUREUS|MOLECULAR|CHARACTERIZATION|METHICILLIN|RESISTANT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":887,"idioma_id":4,"titulo":"Importance of Ship Emissions to Local Summertime Ozone Production in the Mediterranean Marine Boundary Layer: A Modeling Study.","resumen":"Ozone concentrations in the Mediterranean area regularly exceed the maximum levels set by the EU Air Quality Directive, 2008\/50\/CE, a maximum 8-h mean of 120 µg·m &#8722;3 , in the summer, with consequences for both human health and agriculture. There are a number of reasons for this: the particular geographical and meteorological conditions in the Mediterranean play a part, as do anthropogenic ozone precursor emissions from around the Mediterranean and continental Europe. Ozone concentrations measured on-board the Italian Research Council's R. V. Urania during summer oceanographic campaigns between 2000 and 2010 regularly exceeded 60 ppb, even at night. The WRF\/Chem (Weather Research and Forecasting (WRF) model coupled with Chemistry) model has been used to simulate tropospheric chemistry during the periods of the measurement campaigns, and then, the same simulations were repeated, excluding the contribution of maritime traffic in the Mediterranean to the anthropogenic emissions inventory. The differences in the model output suggest that, in large parts of the coastal zone of the Mediterranean, ship emissions Atmosphere 2014, 5 938 contribute to 3 and 12 ppb to ground level daily average ozone concentrations. Near busy shipping lanes, up to 40 ppb differences in the hourly average ozone concentrations were found. It seems that ship emissions could be a significant factor in the exceedance of the EU directive on air quality in large areas of the Mediterranean Basin","palabras_clave":"Mediterranean|Anthropogenic emission"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":888,"idioma_id":5,"titulo":"El riesgo de la población a inundaciones por lluvias como consecuencia de la dinámica de expansión urbana sobre paisajes anegadizos. El caso de la ciudad de corrientes (argentina)","resumen":"El crecimiento espacial de la ciudad de Corrientes, Argentina se ve limitado, en primer lugar, por el río Paraná que imposibilita el crecimiento de la ciudad hacia el norte y el oeste en tanto hacia el este y el sur, predominan paisajes anegadizos.  El objetivo de este trabajo es estudiar la exposición de la población frente a riesgos por inundación urbana, como consecuencia de la expansión de la ciudad de Corrientes sobre espacios anegables. La metodología empleada consistió en la observación  y análisis de imágenes satelitales que permiten analizar cambios recientes, como así también la observación de fotografías aéreas tomadas en el año 1950 y una revisión histórica de la ocupación de nuevos espacios mediante la observación de planos antiguos.","palabras_clave":"CRECIMIENTO ESPACIAL|CIUDAD Y PAISAJE|CORRIENTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":889,"idioma_id":5,"titulo":"Demografía humana e incorporación de cultígenos  en el centro occidente argentino: explorando tendencias en las fechas radiocarbónicas","resumen":"Clásicamente el origen y la dispersión de la agricultura se han explicado al menos parcialmente por variables demográficas. Este estudio, de carácter preliminar, explora el uso de la frecuencia de fechas radiocarbónicas como un proxydemográfico y con tales tendencias se compara la dispersión de cultígenos en el centro occidente argentino. Se acepta la región como el límite sur de la expansión agrícola prehispánica y sobre esa base se comparan las tendencias radiocarbónicas de tres sectores definidos heurísticamente: Norte, Centro y Sur. El trabajo analiza 344 fechas para los últimos 5000 años 14C provenientes de 166 sitios arqueológicos. La suma de probabilidades muestra patrones similares entre los tres sectores pero registra menos variaciones temporales en el Norte, luego en el Centro y finalmente en el Sur, lo que podría entenderse como una correlación con la estabilidad demográfica donde el sector Norte muestra un patrón más estable que en el Centro y estos que el Sur.","palabras_clave":"Centro Occidente Argentino|Mendoza|Holoceno tardío|Agricultura"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":890,"idioma_id":4,"titulo":"2.\tGeophysical Characterization Of The Upper Crust In The Transitional Zone Between The Pampean Flat Slab And The Normal Subduction Segment To The South (32-34º S): Andes Of The Frontal Cordillera To The Sierras Pampeanas","resumen":"The Nazca Plate subducting beneath the South American Plate, has strongly influenced Cenozoic-mountain growth in western Argentina and Chile sectors (32-34{degree sign}S; 70-66{degree sign} W). At these latitudes, the Pampean flat slab has induced the development of prominent mountain systems such as, the Frontal Cordillera, the Precordillera, and the associated Sierras Pampeanas in the eastward foreland region. Through a gravity study between 32-34{degree sign}S, we delimit a series of geological structures that are accommodating shortening in the upper crust and others of regional and subsurface development, without a clearly defined mechanics of deformation. Additionally, through an isostatic analysis, based on the Airy-Heiskanen local compensation model, we obtain a decompensative gravity anomaly map that highlights anomalous gravity sources emplaced in the upper crust and related with known geological structures. In particular, applying the Tilt method, the NW-trending Tunuyan Lineament is depicted south of 33.4{degree sign} S following previous proposals. Using the decompensative gravity anomaly, two profiles were modeled through the study area, using as constraints deep seismic refraction lines, borehole data and geological information. These are density models of the upper crust of this structurally complex area that represent accurately basin geometries and basement topography that constitute a framework for future geological analysis","palabras_clave":"Geodinamica|Flat slab"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":891,"idioma_id":4,"titulo":"Antioxidant effects of the monoterpenes carvacrol, thymol and sabinene hydrate on chemical and sensory stability of roasted sunflower seeds","resumen":"BACKGROUND: Oxidation products and rancid flavours decrease the sensory quality of food products, making them unacceptable to consumers. Synthetic antioxidants are used in many foods to prevent rancidity though their safety is questioned. Monoterpenes are obtained from essential oils and many of them have shown antioxidant activity. The objective was to evaluate the stability of sensory and chemical parameters in roasted sunflower seeds supplemented with carvacrol, thymol, and sabinene hydrate monoterpenes. RESULTS: Five samples were prepared: control roasted sunflower seeds (RS-C), sunflower seeds treated with carvacrol (RS-Car), sabinene hydrate (RS-S), thymol (RS-T), and BHT (RS-BHT). The three monoterpenes (carvacrol, sabinene hydrate, and thymol) provided protection to this food product, inhibiting the formation of oxidative deterioration compounds like peroxides and hexanal, and undesirable off-flavours like oxidized and cardboard flavours. Sabinene hydrate had greater effect preventing peroxide formation during storage than the other monoterpenes. CONCLUSIONS: Carvacrol, sabinene hydrate and thymol could be used as an alternative to synthetic antioxidants for preserving the quality of roasted sunflower seeds.","palabras_clave":"SUNFLOWER|MONOTERPENES|ANTIOXIDANT|LIPIDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":892,"idioma_id":5,"titulo":"GESTOS TÉCNICOS, MORFOLOGÍA Y RASTROS DE USO EN LA ALFARERÍA PREHISPÁNICA DEL SITIO LA PALMERA 2 (PROVINCIA DE ENTRE RÍOS)","resumen":"Este artículo presenta y discute los resultados preliminares obtenidos del estudio de los materiales cerámicos recuperados en el sitio arqueológico La Palmera 2, localizado en el Paraná medio (Departamento Paraná, provincia de Entre Ríos, nordeste de Argentina). Este sitio fue ocupado por grupos cazadores-recolectores complejos en torno al 1056-1032 + 47 AP. Se tienen en cuenta atributos relacionados con los aspectos formales, funcionales y técnicos de las vasijas, cuyo análisis permite avanzar hacia el estudio de la tecnología cerámica de un sector del río Paraná que todavía cuenta con un corpus de datos arqueológicos y una trayectoria de investigación relativamente escasa.","palabras_clave":"TECNOLOGÍA CERÁMICA|SITIO LA PALMERA 2|ARQUEOLOGÍA DEL PARANÁ MEDIO|HOLOCENO TARDÍO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":893,"idioma_id":4,"titulo":"A multi-level approach using Gambusia affinis as a bioindicator of environmental pollution in the middle-lower basin of Suquía River","resumen":"The Suquía River middle-lower basin (Córdoba, Argentina) is subjected to a strong anthropogenic impact because it receives pollutants from different sources. The main goal of this study was to evaluate the introduced fish species Gambusia affinis as a bioindicator of environmental pollution in the middle-lower basin of the Suquía River. The assessment was performed by measuring biomarkers at different levels of biological organization, at two sampling sites (before and after Córdoba city), and at dry and wet seasons. Water quality evaluation was made through a water-quality index (based on physico-chemical parameters), heavy-metals and pesticides concentrations in water. The water quality varied between sampling sites, showing the most degraded conditions downstream Córdoba city. The same pattern of variation was detected in the biomarkers studied, mainly in: gill and liver histopathological indexes, copulatory organ (gonopodium) morphology and vitellogenin expression in males and females. The present study characterized the environmental conditions in the middle-lower basin of the Suquía River and revealed the low freshwater quality at the most polluted site. Although G. affinis is an introduced species, it could be considered a good sentinel of water resource quality of invaded Neotropical basins. Our results demonstrated the importance of addressing the environmental quality monitoring through an integrated analysis of water quality parameters together with histological, morphological and molecular parameters. Thus, our study provides a good model for application in other basins of South America.","palabras_clave":"Fish|Biomarkers|Metals|Pesticides|Freshwater quality"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":894,"idioma_id":10,"titulo":"Palavra e política em Aristóteles: uma discussão com Platão e os sofistas","resumen":"RESUMO:   Este artigo reflete sobre a relação entre linguagem e política na teoria política clássica. Em primeiro lugar, põe-se ênfase na tensão entre Platão e os sofistas. Em segundo lugar, vamos trabalhar este problema no pensamento de Aristóteles, tentando mostrar como a linguagem desempenha um papel não instrumental em Aristóteles, e é a primeira condição de vínculo social e fundamento da comunidade política.","palabras_clave":"Linguagem|Política|Teoría Política Clássica|Comunidade política"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":895,"idioma_id":5,"titulo":"Sociología moral del dinero en el mundo popular.","resumen":"Este articulo analiza la conformación de una nueva infraestructura monetaria del mundo popular. Muestra el rol creciente del dinero en estos sectores y se pregunta sobre las nueva formas de integración social que estos cambios suponen. Aborda estos cambios desde una sociología moral del dinero. Utiliza materiales empíricos de un trabajo de campo en las barriadas de la periferia de la Ciudad de Buenos Aires entre 2006-2010.     Palabras claves: dinero; moral; clases populares; sociología económica;","palabras_clave":"Dinero|Moral|Mundo Popular|America Latina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":896,"idioma_id":4,"titulo":"?The moral performativity of credit and debt in the slums of Buenos Aires.?","resumen":"Classic works in anthropology and sociology have essentialized formal capitalist credit and their alternative forms, be they community-based or informal. The financialization of everyday life has produced the return to this one-sided narrative. My aim in this article is to show how the moral dimension of financial practices does not represent the flip side of capitalist institutions. The economization of morality is a transaction that takes place not only along the margins but also at the heart of financial practices.  A moral sociology of money becomes increasingly necessary as the financialization of the everyday life develops.  I use ethnographic data that I collected between 2006 and 2011 during my fieldwork in the slums of Buenos Aires. I attempted to understand the growing role and the multiple forms of credit and debt in the economy of the poor. My ethnographic reconstruction is guided by a conceptual foundation that allows for an anti-essentialist interpretation of the moral dimension of credit and debt. In this article I propose considering the concept of moral capital as a kind of guarantee together with other kinds of capital such as economic or legal capital.   My argument seeks to deessentialize the opposition between informal and community-based systems and the so-called capitalist systems, revealing their continuity through the rules that must be complied with in order to accumulate moral capital as a way to access credit and pay off debts. The hypothesis that moral capital multiplies economic capital suggests that there are differentiations and inequalities that not only regulate borrowers but also allow them to be distinguished individually.  The financialization of the economy is translated into a space for moral distinction that provides an outline for a new topography of the moral antagonism in the economic life.","palabras_clave":"Deuda|Dinero|Mundo popular|Finanzas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":897,"idioma_id":5,"titulo":"DISEÑO PARTICIPATIVO DE ESPACIOS URBANOS BIOCLIMÁTICOS. EXPERIENCIA EN MENDOZA, ARGENTINA","resumen":"La producción de viviendas de interés social cuestiona el éxito de proyectos típicos destinados a individuos indefinidos con soluciones repetitivas. Las viviendas unifamiliares requieren diseños que respondan a situaciones y problemas particulares. El trabajo reconoce los beneficios de las técnicas participativas de diseño para la producción social y sustentable del hábitat, equilibrando soluciones bioclimáticas e intereses de los beneficiarios. Metodológicamente aplica talleres comunitarios, tradicionalmente orientados sólo a la vivienda, en el diseño participativo de espacios urbanos conexos y sus redes. Se analizan los resultados de la incorporación de conceptos de sustentabilidad energética y ambiental en la selección de alternativas de diseño. Los resultados indican que es posible conciliar el diseño de espacios urbanos con mejoras energéticas, ambientales y sobrecosto cero. Esto satisface las expectativas de la comunidad respecto de su desempeño bioclimático, habilitando la implementación de talleres de diseño participativo en la concientización de la problemática actual de las infraestructuras urbanas. ","palabras_clave":"HÁBITAT BIOCLIMÁTICO|TALLERES DE DISEÑO PARTICIPATIVO|URBANIZACIÓN,|VEGETACIÓN URBANA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":898,"idioma_id":5,"titulo":"La especificidad de la alfarería del valle Calchaquí (Salta) en el contexto más amplio del espacio santamariano.","resumen":"La alfarería tardía del valle Calchaquí aún requiere de una profundización en su análisis y caracterización propia dentro del amplio espectro de la cerámica ?santamariana? en la que se incluye. Presentamos una síntesis de los resultados del estudio de piezas completas de colecciones de museo y privadas procedentes de la región con el objetivo de ahondar en su variabilidad y especificidad. Partiendo de nuestras investigaciones previas, en esta oportunidad sumamos información de la colección del sitio Kipón y de un conjunto de urnas provenientes de distintos sectores del valle y de diversas colecciones, lo que permitió reconocer la variedad de la cerámica calchaquí afinando las semejanzas\/diferencias intersitio y plantear las particularidades a nivel regional e interregional de una de las formas características de la cerámica ?santamariana?, las urnas para párvulos.       ","palabras_clave":"V. Calchaquí|alfarería|tardía|especificidad regional"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":899,"idioma_id":4,"titulo":"Negative, neutral, and positive interactions among nonnative plants: patterns, processes, and management implications","resumen":"The movement of species is one of the most pervasive forms of global change, and few ecosystems remain uninvaded by nonnative species. Studying species interactions is crucial for understanding their distribution and abundance, particularly for nonnative species because interactions may influence the probability of invasion and consequent ecological impact. Interactions among nonnatives are relatively understudied, though the likelihood of nonnative species co-occurrence is high. We quantify and describe the types of interactions among nonnative plants and determine what factors affect interaction outcomes for ecosystems globally. We reviewed 65 studies comprising 201 observations and recorded the interaction type, traits of the interacting species, and study characteristics. We conducted a census of interaction types and a meta-analysis of experiments that tested nonnative competition intensity. Both methods showed that negative and neutral interactions prevailed, and a number of studies reported that the removal of a dominant nonnative led to competitive release of other nonnatives. Positive interactions were less frequently reported and positive mean effect sizes were rare, but the plant characteristics nitrogen fixation, life cycle (annual or perennial), and functional group significantly influenced positive interactions. Positive interactions were three times more frequent when a neighboring nonnative was a nitrogen fixer and 3.5 times lower when a neighboring nonnative was an annual. Woody plants were two or four times more likely to have positive interactions relative to grasses or herbs, respectively. The prevalence of negative interactions suggests that managers should prepare for reinvasion of sites when treating dominant nonnatives. Though positive interactions were infrequent, managers may be able to anticipate positive interactions among nonnatives based upon traits of the co-occurring invaders. Predicting positive nonnative interactions is an important tool for determining habitat susceptibility to a particular invasion and for prioritizing management of nonnatives with a higher likelihood of positive interactions.","palabras_clave":"plant plant interaction|competition|invasion|global change"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":901,"idioma_id":4,"titulo":"Flexible structured systems made of ceramic fibers containing Pt-NaY zeolite used as CO oxidation catalysts","resumen":"Catalytic ceramic papers were developed by incorporating Pt-NaY zeolite to ceramic papers. The necessary mechanical strength was enhanced by the addition of natural borate compounds, which confer elasticity and resistance similar to those obtained using colloidal suspensions, which are the most commonly used binders. Pt-NaY zeolite was incorporated into ceramic papers either during the papermaking process or by spraying a zeolitic suspension on ceramic papers. The partial encapsulation of the faujasite by the sintering of the borate compound during the calcination step made catalytic ceramic papers less active toward the CO oxidation reaction than the corresponding traditional systems (Pt-NaY zeolite coated onto cordierite monoliths or the powder Pt-NaY faujasite). Light-off curves indicated that the activity of Pt-NaY zeolite was preserved when incorporating the zeolitic component by spray, in which case the CO oxidation reaction ran away at ca. 130 °C, and the total CO conversion was achieved at 150 °C, maintaining 100 % CO conversion for more than 90 h.","palabras_clave":"Ceramic papers|Zeolite"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":902,"idioma_id":4,"titulo":"The impact of significant input of fine sediment on benthic fauna at tributary junctions: a case study of the Bermejo? Paraguay River confluence, Argentina","resumen":"This study examines the morphological features, suspended sediment inputs and hydraulic conditions within a large river in  association with ecological patterns before and after a tributary confluence. In order to examine these effects, the  macroinvertebrate distributions from three reaches of the Paraguay and Bermejo Rivers (Paraguay?Argentina) are investigated.  The Bermejo River is a tributary that supplies significant quantities of fine sediment to the Paraguay River, primarily in  suspension. Two reaches were examined on the Paraguay River, upstream and downstream of the Bermejo River junction, with  the third study reach located on the Bermejo River, upstream of the confluence with the Paraguay River. The results provide clear  evidence that a significantly increased loading of fine sediment at a river confluence has effects on the distribution and potential  movement of benthic invertebrates in the lotic environment by representing physical barriers at affected sites. These effects may  be important at both local and regional scales, and such increases in suspended sediment (especially associated with  anthropogenic change) may thus pose a major threat to ecosystem integrity that has been historically underestimated.","palabras_clave":"ECOHYDROLOGY|BENTHIC INVERTEBRATES|FINE SEDIMENT LOAD|CONFLUENCE SEDIMENT DYNAMICS|LARGE RIVER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":903,"idioma_id":5,"titulo":"El anacronismo democrático. Militancia y democracia en las memorias generacionales del primer kirchnerismo","resumen":"      El objetivo general de esteartículo es exponer resultados preliminares de una investigación doctoral en elámbito del análisis del discurso y la historia de las ideas acerca de lastradiciones políticas del primer kirchnerismo (2003-2007). En el marco de estapesquisa, indagamos las relaciones imaginarias que el gobierno argentinoestablece entre militancia juvenil de los años setenta y democracia, tomando encuenta los discursos públicos del ex presidente Néstor Kirchner. Intentamosdemostrar cómo la palabra oficial interpreta la militancia setentista en lostérminos de un programa y una cultura democráticos postergados por laimplantación del neoliberalismo (1976-2001). Afirmamos,finalmente, que este anacronismo democráticoconstituye una dimensión inescindible del gesto refundacional del primerkirchnerismo, basado en un clivaje generacional.   ","palabras_clave":"Anacronismo|Militancia|Años setenta|Democracia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":904,"idioma_id":4,"titulo":"Cold-storage of Piezodorus guildinii (Hemiptera: Pentatomidae) eggs for rearing 1 Telenomus podisi (Hymenoptera: Platygastridae)","resumen":"Piezodorus guildinii (Hemiptera: Pentatomidae) is an important soybean pest, and oneof its main natural enemies is Telenomus podisi (Hymenoptera: Platygastridae). Rearingof the parasitoid is constrained by the hosts´ egg quality, which deteriorates after fewgenerations in laboratory, therefore, cold-stored host eggs utilization could be a usefultool for augmentative biological control. Thus, the objective was to evaluate the quality ofP. guildinii cold-stored eggs, on the performance of parental and F1 generation of T.podisi. Host eggs 24 hour old were stored at -18°C for one (N= 53), two (N= 28) or threemonths (N= 29), and approximately 40 host eggs were offered to a T. podisi female pertreatment, for 48 hours. The control treatment consisted of 24-hour-old non-frozen hosteggs, obtained and kept at 24°C (N= 55). Parental generation parasitism and progeny´semergence on frozen eggs was significantly lower than on non-frozen eggs, even for theshorter storage period. Male proportion and preimaginal development time of theprogeny increased with freezing period. However, parasitism proportion caused by adultsof F1, and emergence, male proportion, and preimaginal development time of F2 were notaffected. Although the performance of T. podisi on frozen P. guildinii eggs wassignificantly lower than on nonfrozen ones, host eggs storage for up to two monthsallowed obtaining a parasitism rate of 40% with a high emergence rate. This could behelpful enough to maintain mass rearings, mainly during the host hibernation period, andto enhance field parasitism when host is scarce.","palabras_clave":"CRIA MASIVA|PARASITOIDES|DESEMPEÑO|ALMACENAMIENTO DE HOSPEDADORES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":905,"idioma_id":5,"titulo":"PALEOBIOINDICADORES DEL FIN DEL MUNDO: OSTRÁCODOS Y QUIRONÓMIDOS DEL EXTREMO SUR DE SUDAMÉRICA EN AMBIENTES LACUSTRES CUATERNARIOS","resumen":"El objetivo de este trabajo es resumir el estado de las investigaciones paleolimnológicasbasadas en bioindicadores pertenecientes al Phylum Arthropoda, en particularostrácodos (Crustacea) y quironómidos (Diptera), en el ámbito de la RepúblicaArgentina. Si bien la mayor parte de las investigaciones se han efectuado en el ámbitode la Patagonia, donde han permitido la reconstrucción paleolimnológica de registrosdesde el último Máximo Glacial y el Holoceno, estos estudios se fueron extendiendoprogresivamente hacia las regiones pampeanas, Cuyo y el Noroeste, abarcando distintasventanas temporales del Pleistoceno Tardío y el Holoceno. Son cada vez más numerosaslas investigaciones que integran datos actuales y fósiles de ostrácodos y quironómidos, loque ha permitido desarrollar funciones de transferencia dando lugar a reconstruccionescuantitativas robustas y mejorar las interpretaciones cualitativas basadas en la presenciade especies indicadoras. Ambos tipos de reconstrucciones son cada vez más frecuentementecombinadas con otros proxies biológicos, químicos o físicos, brindando unmarco multiproxy que permite reconstrucciones integrales de los ecosistemas lacustrescuaternarios. Los estudios de ostrácodos y quironómidos de registros lacustres han permitidono sólo reconocer las tendencias ambientales y climáticas de los últimos miles de años,sino también reconocer eventos climáticos de media y alta frecuencia de interés global,tales como el Younger Dryas, el Antarctic Cold Reversal, el Evento Frío 4,2ka, y la PequeñaEdad de Hielo, así también como los cambios climáticos e impactos antrópicos del siglo 20.","palabras_clave":"Ostrácodos|Quironómidos|Ambientes lacustres cuaternarios|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":906,"idioma_id":4,"titulo":"A Morphological Analysis of Pigmented Skin Lesions through Digital Image Processing","resumen":"Melanoma is the most malignant type of skin cancer due to its ability to metastasize. Since early detection is the best way to prevent it, many detection techniques have been developed, such as the ABCD rule, the Menzies method and the 7-point checklist. Digital image processing is nowadays a powerful and useful tool for the analysis of biomedical images, resulting in great help in the diagnosis of many diseases. Consequently, by using this tool it is possible to develop software capable of automatically recognizing different patterns of pigmented skin lesions. In this paper we propose an algorithm based on the morphological analysis of an image of a pigmented skin lesion in order to characterize and quantify its malignity according to the ABCD rule developed by Stolz in 1994. The proposed method includes image enhancement techniques, the segmentation of the injured area together with morphological algorithms to obtain the ABCD characteristics, and the calculation of the Total Dermoscopy Score (TDS), which will let us classify the lesion as benign, suspicious or malign. The results obtained show that the proposed algorithm is reliable and could help the medical professional in the diagnosis of melanoma.","palabras_clave":"Morphological Analysis|Digital Image Processing |Melanoma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":907,"idioma_id":5,"titulo":"PROYECCIONES FUTURAS ASOCIADA A LOS EVENTOS EXTREMOS FRIOS EN EL SUDESTE DE SUDAMERICA SOBRE LA PERSPECTIVA DEL MODELO HADCM3","resumen":"          Las simulaciones con el modelo HadCM3 fueron de las  primeras disponibilizadas para el análisis de las proyecciones futuras, lo cual  se refleja en la literatura que describe principalmente las variables de  temperatura y precipitación en particular para América del Sur. Complementariamente  a estos estudios, en este trabajo se propone utilizar dicho modelo para analizar  las proyecciones futuras asociadas a los eventos extremos fríos en aquellas  regiones del sudeste de Sudamérica afectadas por los mismos. El objetivo es  investigar los cambios en la circulación atmosférica en el sudeste de  Sudamérica asociada a eventos extremos fríos, en el escenario de emisiones  futuras más crítico denominado A2, para el periodo 2081-2100 respecto a un  periodo climatológico de referencia 1961-1990, considerando el modelo HadCM3 y  los datos del reanálisis NCEP\/NCAR. A partir de la temperatura media diaria en  850 hPa, se identifican los eventos por debajo de 0° para los meses de mayo a  septiembre, componiéndose los cinco eventos  más extremos para tres áreas que incluyen la Pampa  Húmeda (área 1), Uruguay y sur de Brasil (área 2), la parte oriental de  Paraguay, norte de Argentina y sur de Brasil (área 3). Los patrones de  circulación así obtenidos son analizados tanto para los reanálisis como para  las simulaciones en el clima presente y futuro. En particular el reanálisis  permite evaluar la capacidad del modelo HadCM3 en simular la circulación  atmosférica de dichos eventos en el clima presente y así conocer el grado de  certeza en el escenario más crítico del clima futuro.           Los resultados muestran para el clima presente que el  modelo simula la incursión de las isotermas de 0°C más al norte respecto del  reanálisis, a excepción del área 3 que limita con los trópicos, con anomalías  negativas de temperatura más intensas y más extensas en términos latitudinales.  A pesar que las configuraciones de los campos de presión sean similares al  reanálisis, se aprecia una mayor penetración del anticiclón continental, a  excepción del área 3, con una intensificación de las anomalías en las respectivas  áreas. El modelo también tiende a simular una componente de viento del sur más  intensa en 850 hPa y captura la profunda vaguada sobre el continente en niveles  altos con el jet subtropical bien configurado, típico de estos eventos  extremos.          En el escenario futuro, el modelo no proyecta eventos  extremos de temperatura por debajo de 0°C para el área 3, restringiendo la  incursión de la isoterma de 0° C a latitudes más al sur en las otras dos áreas  respecto a la simulación en el clima presente, en concordancia con el aumento  de temperatura media que el modelo proyecta para Sudamérica. Sin embargo, las  anomalías negativas de temperatura siguen siendo del mismo orden que las  simuladas en el clima presente con una intensificación del viento del sur,  producto del mayor gradiente anómalo de presión en 850 hPa y una profundización  de la vaguada con el acople del jet polar y subtropical que se proyecta sobre  las áreas 1 y 2.  ","palabras_clave":"PROYECCIONES FUTURAS|EVENTOS EXTREMOS FRÍOS|ESCENÁRIOS CLIMÁTICOS|CAMBIO CLIMÁTICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":908,"idioma_id":4,"titulo":"'Chasmatosaurus ultimus', a putative proterosuchid archosauriform from the Middle Triassic, is an indeterminate crown archosaur","resumen":"Proterosuchids represent the earliest known radiation of thehighly diverse and important clade Archosauriformes (Gauthieret al., 1988; Nesbitt, 2011; Ezcurra et al., 2013). Huene (1908)erected Proterosuchidae as a monotypic Linnean family containingonly Proterosuchus fergusi from the lowermost Triassic ofSouth Africa, and several other species have been referred tothis group in the subsequent century. However, phylogeneticanalyses have provided only partial support for the existence of adiverse proterosuchid clade, and it is possible that some or evenmost putative proterosuchids form a series of outgroups to morederived archosauriforms rather than a monophyletic group(Ezcurra et al., 2010, 2013). Proterosuchids were historicallyclassified alongside erythrosuchids in the Proterosuchia (e.g.,Charig and Reig, 1970), but cladistic analyses (e.g., Benton,1985; Gauthier et al., 1988; Gower and Sennikov, 1997; Ezcurraet al., 2010; Nesbitt, 2011) have uniformly found erythrosuchidsto be phylogenetically closer to Archosauria (using a crowngroupdefinition for the clade) than are any putative proterosuchids.Many of the species that have been assigned to Proterosuchidaerequire anatomical and taxonomic reevaluation (e.g.,Ezcurra et al., 2010, 2013, 2014; Ezcurra, 2014), a research effortthat is essential in order to clarify the phylogenetic relationshipsof the earliest archosauriforms and patterns of character evolutionin taxa of this grade.","palabras_clave":"Archosauriformes|Archosauria|Triassic|China"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":910,"idioma_id":4,"titulo":"Phosphorylated H2AX in parthenogenetically activated, in vitro fertilized and cloned bovine embryos.","resumen":"In vitro embryo production methods induce DNA damage in the embryos. In response to these injuries, histone H2AX is phosphorylated (&#947;H2AX) and forms foci at the sites of DNA breaks to recruit repair proteins. In this work, we quantified the DNA damage in bovine embryos undergoing parthenogenetic activation (PA), in vitro fertilization (IVF) or somatic cell nuclear transfer (SCNT) by measuring &#947;H2AX accumulation at different developmental stages: 1-cell, 2-cell and blastocyst. At the 1-cell stage, IVF embryos exhibited a greater number of &#947;H2AX foci (606.1 ± 103.2) and greater area of &#947;H2AX staining (12923.6 ± 3214.1) than did PA and SCNT embryos. No differences at the 2-cell stage were observed among embryo types. Although PA, IVF and SCNT were associated with different blastocyst formation rates (31.1%, 19.7% and 8.3%, P < 0.05), no differences in the number of &#947;H2AX foci or area were detected among the treatments. &#947;H2AX is detected in bovine preimplantation embryos produced by PA, IVF and SCNT; the amount of DNA damage was comparable among those embryos developing to the blastocyst stage among different methods for in vitro embryo production. While IVF resulted in increased damage at the 1-cell embryo stage, no difference was observed between PA and SCNT embryos at any developmental stage. The decrease in the number of double-stranded breaks at the blastocyst stage seems to indicate that DNA repair mechanisms are functional during embryo development.","palabras_clave":"Fertililización in vitro|Clonación|Partenogenesis|Histona H2AX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":912,"idioma_id":5,"titulo":"El montaje de la ausencia: las fotos reconstruidas de Lucila Quieto","resumen":"Artículo sobre las fotos reconstruidas de la serie fotográfica Arqueología de la ausencia de Lucila Quieto (Buenos Aires, 1977), cuyo padre Carlos Quieto fue desaparecido por la última dictadura militar argentina cuando ella aún no había nacido.","palabras_clave":"LUCILA QUIETO|MONTAJE FOTOGRAFICO|DICTADURA|MEMORIAS SOCIALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":913,"idioma_id":5,"titulo":"Análisis de los agentes de alteración del registro arqueológico identificados en las costa norte de Santa Cruz (Patagonia, Argentina)","resumen":"Actualmente en el área comprendida dentro del proyecto de investigación Arqueología de la costa norte de Santa Cruz?, se ha cuenta con amplio  conocimiento de las características del registro arqueológico, pero así también de los principales procesos de alteración del mismo. En este trabajo se presentan los agentes de alteración identificados, tanto naturales como antrópicos, que afectan al registro arqueológico. Se analiza la acción de los agentes a nivel areal a partir de un estudio comparativo en distintas localidades arqueológicas. Para ello se realizaron mapeos utilizando Sistemas de Información Geográfica a partir de la información disponible, lo que permitirá planificar nuevas investigaciones a partir de la identificación de sectores con mayor riesgo de destrucción, señalando prioridades y utilizando esos datos para la toma de decisiones vinculadas con la conservación del patrimonio cultural y natural.","palabras_clave":"COSTA NORTE DE SANTA CRUZ|AGENTES DE ALTERACIÓN|SISTEMAS DE INFORMACIÓN GEOGRÁFICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":914,"idioma_id":4,"titulo":"Nearly constant loss in crystalline oxide-ion conductor Gd2Zr2O7","resumen":"We present a study of the nearly constant loss regime in the oxide-ion conductor Gd2Zr2O7by using Impedance Spectroscopy measurements.At enough low temperature, between 173 and 253 K, the dielectric loss is found to be almost temperature and frequency independentwithin the whole experimental frequency range (10 Hz - 1 MHz). However, a symmetric and very broad relaxation peak is clearly resolved in the loss spectra. This peak shows a thermally activated peak frequency with activation energy E= 0.29 ± 0.02 eV, and its origin is discussed in terms of previously proposed models for the nearly constant loss.","palabras_clave":"IONIC CONDUCTIVITY|DIELECTRIC LOSS|DIELECTRIC RELAXATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":915,"idioma_id":4,"titulo":"Characterization of the key antigenic components of pertussis vaccine based on outer membrane  vesicles","resumen":"Pertussis has resurged during the last two decades in different countries. In particular in the 2010-2013 period large outbreaks were detected in US, Australia, UK and The Netherlands with significant mortality in infants. The epidemiological situation of pertussis points out the need to develop new vaccines and in this regard we previously developed a new vaccine based on outer membrane vesicles (OMVs) which have been shown to be safe and to induce protection in mice. Here we have further investigated the properties of OMVs vaccines; in particular we studied the contribution of pertussis toxin (PTx) and pertactin (Prn) in OMVs-mediated protection against pertussis. PTx-deficient OMVs and Prn-deficient OMVs were obtained from defective Bordetella pertussis mutants. The absence of PTx or Prn did compromise the protective capacity of the OMVs formulated as Tdap vaccine. Whereas the protective efficacy of the PTx-deficient OMVs in mice was comparable to Prn-deficient OMVs, the protective capacity of both of them was significantly impaired when it was compared with the wild type OMVs. Interestingly, using OMVs obtained from a B. pertussis strain which does not express any of the virulence factors but expresses the avirulent phenotype; we observed that the protective ability of such OMVs was lower than that of OMVs obtained from virulent B. pertussis phase. However, it was surprising that although the protective capacity of avirulent OMVs was lower, they were still protective in the used mice model. These results allow us to hypothesize that OMVs from avirulent phase shares protective components with all OMVs assayed. Using an immune proteomic strategy we identified some common components that could play an important role in protection against pertussis.","palabras_clave":"ACELLULAR VACCINE|AVIRULENT PHASE|BORDETELLA PERTUSSIS|OMVs|WOOPING COUGH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":916,"idioma_id":6,"titulo":"Les dispositifs du corps dans le jeu d'acteur","resumen":"Es mi propósito realizar un abordaje al Nuevo Cine Argentino (NCA) a partir de las políticas de actuación, es decir, de los modos en que el cuerpo del actor constituye uno de los dispositivos fundamentales para la organización de sentidos en los films y fuera de ellos, en el terreno de lo social.  Si bien uno de los elementos que permiten delinear la existencia de un 'nuevo' cine a partir de mediados de los años '90 es una renovación tanto en las formas de actuación, como en la procedencia, formación y habitus de los actores, este tema no ha sido abordado de manera específica hasta el momento.  Con la finalidad de trazar un mapa de las políticas de actuación, plantearé la existencia de cuatro dispositivos fundamentales: 1. la tendencia naturalista-realista, 2. la participación de no actores, 3. la mostración del artificio de la representación, 4. una combinación de modos de realismo con la ostentación del artificio o con la participación de no actores.  Ya en los primeros films del NCA es posible rastrear formas de estos cuatro dispositivos de actuación que, además, se extenderán y profundizarán con el correr de los años. Como películas modelo iniciales, podemos mencionar: 1. Pizza, birra y faso (Bruno Stagnaro, Adrián Caetano, 1997); 2. La libertad (Lisandro Alonso, 2001); 3. Silvia Prieto (Martín Rejtman, 1998); 4. Mundo grúa (Pablo Trapero, 1999), La ciénaga (Lucrecia Martel, 2001). Sin perseguir ningún intento de exhaustividad, propongo rastrear algunos casos de estas modalidades en el cine posterior.   El análisis de estos dispositivos conlleva el tratamiento de algunas temáticas que los atraviesan y que merecen atención, en tanto constituyen modos de posicionamiento político respecto de la constitución del campo cultural y de la construcción del público. Entre ellas: el ingreso de actores del circuito de teatro independiente al NCA, la presencia de actores con reconocimiento público en el cine independiente, los contagios y distancias de los lenguajes actorales en el cine de taquilla y en el NCA, la realización cinematográfica por parte de directores de teatro independiente, los modos de actuación de los mismos actores en teatro y en cine.","palabras_clave":"CUERPOS|CONFIGURACIÓN DE SENTIDOS|NUEVO CINE ARGENTINO|DISPOSITIVOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":917,"idioma_id":5,"titulo":"Quisiera preguntar, me urge, ¿por qué los problemas de los niños y jóvenes de América Latina no son problemas de los niños y jóvenes cubanos?","resumen":"En el presente artículo presentamos una reflexión en el campo de estudios sobre infancia y juventud a partir de la participación de las autoras en la Cuarta Escuela Internacional de Posgrado de la Red de Posgrados en Infancia y Juventud (RedINJU): ?Democracia, derechos humanos y ciudadanía: infancias y juventudes en América Latina y el Caribe?, organizada por CLACSO, en la ciudad de Tijuana, México.","palabras_clave":"INFANCIA|JUVENTUD|TIJUANA|CUBA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":919,"idioma_id":5,"titulo":"Educación y lucha de clases. Aníbal Ponce.","resumen":"A ochenta años del conjunto de conferencias que originaran luego el libro 'Educación y lucha de clases' de Aníbal Ponce, y a propósito de la reedición realizada por Ediciones Luxemburg de Argentina se presenta un análisis de la obra ponciana en y desde el siglo XXI.","palabras_clave":"PEDAGOGÍA|HISTORIA DE LA EDUCACIÓN|ANÍBAL PONCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":922,"idioma_id":4,"titulo":"Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies.","resumen":"Objective The purpose of the present study was to determine whether elevated dietary Na intake could be associated with CVD mortality.  Design We performed a systematic review and meta-analysis of prospective studies representing the general population. The adjusted relative risks and their 95 % confidence intervals were pooled by the inverse variance method using random-effects models. Heterogeneity, publication bias, subgroup and meta-regression analyses were performed.  Settings MEDLINE (since 1973), Embase (since 1975), the Cochrane Library (since 1976), ISI Web of Science, Google Scholar (until September 2013) and secondary referencing were searched for inclusion in the study.  Subject Eleven prospective studies with 229 785 participants and average follow-up period of 13·37 years (range 5·5?19 years).  Results Higher Na intake was significantly associated with higher CVD mortality (relative risk=1·12; 95 % CI 1·06, 1·19). In the sensitivity analysis, the exclusion of studies with important relative weights did not significantly affect the results (relative risk=1·08; 95 % CI 1·01, 1·15). The meta-regression analysis showed that for every increase of 10 mmol\/d in Na intake, CVD mortality increased significantly by 1 % (P=0·016). Age, hypertensive status and length of follow-up were also associated with increased CVD mortality.  Conclusions Higher Na intake was associated with higher CVD mortality in the general population; this result suggests a reduction in Na intake to prevent CVD mortality from any cause.","palabras_clave":"Cardiovascular diseases|Sodium|Meta-analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":923,"idioma_id":5,"titulo":"Factores asociados a las calificaciones escolares como proxy del rendimiento educativo","resumen":"Tras once años en los que el Estado argentino ha llevado adelante diferentes políticas de inclusión educativa, cabe preguntarse sobre los logros educativos. ¿Cuáles son los factores sociodemográficos, socioeconómicos y socioculturales asociados a las calificaciones escolares como proxy del rendimiento educativo en asignaturas como matemática y lengua en la educación primaria y secundaria?  El estudio permitió reconocer desigualdades de género y de trayecto educativo relativamente conocidas. Sin embargo, también se han explorado otros factores socioculturales que inciden con relativa independencia de factores socioeconómicos y de gestión educativa como: la presencia de libros en el hogar, el comportamiento lector y la narración oral. Asimismo, el análisis realizado permitió especificar la relación entre la estratificación social y el tipo de gestión educativa de las escuelas.   Para ello se realizaron análisis a través de modelos de regresión logística con base en los microdatos de la Encuesta de la Deuda Social Argentina (EDSA-UCA) para el año 2011.","palabras_clave":"DESIGUALDAD SOCIAL|RENDIMIENTO ESCOLAR|CALIFICACIONES ESCOLARES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":924,"idioma_id":4,"titulo":"Mary?s Green Brilliance:  The Case of the Virgin of Copacabana","resumen":"This article reveals the latest research results on the polychromed sculpture of the Virgin of Copacabana of Bolivia, created by Francisco Tito Yupanqui in 1582.  By considering its materials as documents of the past, this study examines the trade of pigments used in its manufacture and the use of gold, together with the presence of a recently-identified green color linked to prehispanic cultural practices.  Other similar images, such as the Virgin of the Rosary in Tunja, the Carabuco Cross, and Mexico?s Virgin of Guadalupe, are also examined.","palabras_clave":"COLONIAL ART|MATERIALS|PIGMENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":928,"idioma_id":4,"titulo":"The nautiloid Family Eothinoceratidae from the Floian of the Central Andean Basin (NW Argentina and South Bolivia)","resumen":"A single confidently dated species of cephalopod is so far known in the Tremadocian of the southern Central Andean Basin (NW Argentina and southern Bolivia). This species belongs to the Eothinoceratidae and has a strong affinity mainly with Avalonia. During the Floian, a notable increase in diversity took place, with the appearance of a variety of families represented by several genera, in particular, within the Family Eothinoceratidae. In addition to the previously described species from southern Bolivia, we evaluate the other records of that family from the Central Andean Basin, and propose the following new taxa: Saloceras sikus sp. nov., Saloceras quena sp. nov., Mutveiceras gen. nov., and Mutveiceras cienagaensis sp. nov.We also describe Margaritoceras diploide, Margaritoceras sp., and Mutveiceras sp. From a palaeogeographic perspective, the cephalopod fauna shows affinities mainly with those of England,Wales, and theMontagne Noire (cold water Gondwana and peri-Gondwana). As with other cephalopod faunas of mid to high palaeolatitudes, eothinoceratids occur along with other cephalopods forming assemblages of low morphological diversity. We interpret the forms described here as demersal with a subvertical poise, but capable of making rapid buoyancy changes, living in a wide spectrum of shallow offshore to shoreface settings.","palabras_clave":"NAUTILOIDEA|EOTHINOCERATIDAE|ORDOVIACIAN|CENTRAL ANDEAN BASIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":929,"idioma_id":4,"titulo":"QSPR Studies on Refractive Indices of Structurally Heterogeneous Polymers","resumen":"We developed a predictive Quantitative Structure?Property Relationship (QSPR) for the refractive indices of 234structurally diverse polymers. Themodel involves a singlemolecular descriptor and a conformation-independentapproach. The most appropriate polymer structure representation was investigated by considering 1?5monomeric repeating units. The established equations were validated and tested through various well-knowntechniques, such as the use of an external test set of compounds, the Cross-Validation method, YRandomizationand Applicability Domain, and finally a comparison was also performed to published resultsfrom the li terature. The developed QSPR could be useful for assisting the development of new polymericmaterials.","palabras_clave":"QSPR Theory |Polymer|Refractive index|Graph theory|CORAL software"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":931,"idioma_id":5,"titulo":"Movimientos Sociales y formas alternativas al desarrollo. El N&#771;ande Reko y la bu&#769;squeda de la tierra sin mal del pueblo Guarani&#769; de Tarija, Bolivia","resumen":"En este artículo se trabaja una perspectiva crítica a la noción de desarrollo a partir de las experiencias y nociones recogidas entre la Asamblea del Pueblo Guaraní en Tarija (Bolivia). En el marco de las disputas en torno a los recursos naturales y el territorio en el país andino se pueden vislumbrar diferentes concepciones y 'mundos de vida' contrapuestos entre las miradas neodesarrollistas desplegadas desde el Estado y las empresas extractivas y las miradas ancladas en las perspectivas de los propios pueblos originarios, en este caso el 'Ñande Reko' ('Nuestro modo de ser\/estar', en idioma guaraní), que implican usos y sentidos contrapuestos en las formas de habitar los territorios y de utilizar los recursos naturales de la región","palabras_clave":"MOVIMIENTOS SOCIALES|DESARROLLO|BOLIVIA|PUEBLOS INDÍGENAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":934,"idioma_id":4,"titulo":"Institutions, Credibility and Crisis: the Inconsistencies of Argentine Exchange Rate Policy (1991-2006)","resumen":"The purpose of this article is twofold. The first is to explain the time inconsistencies of the convertibility regime that led to the 2001 crisis. The argument suggests that the credibility requirements for convertibility induced a dynamic of legal, fiscal, financial and external commitments that increased exit costs and time inconsistencies. The second objective is to explain the tensions of the floating regime that replaced convertibility in 2002. We describe the effects of a floating exchange rate on macroeconomic imbalance and the growing tension between competitiveness and inflation.","palabras_clave":"EXCHANGE RATE|CONVERTIBILITY|CREDIBILITY|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":935,"idioma_id":5,"titulo":"La relevancia de las noticias en la prensa gráfica. Una reflexión teórico metodológica a partir del análisis del conflicto entre las corporaciones agrarias y el gobierno argentino, en 2008.","resumen":"El objetivo general del presente trabajo es establecer cuáles son las variables que condicionan la importancia de un caso en las coberturas de prensa gráfica. En función de ello, guiado principalmente por los preceptos de la teoría de la Agenda Setting, se realizó un análisis de contenido sobre la cobertura del denominado 'conflicto del campo' de 2008 en la Argentina. El trabajo analítico permitió construir un índice de importancia aplicable al estudio de otros casos.     INDEXADA EN: Índice de Revistas Mexicanas de Investigación Científica y Tecnológica del CONACYT, SciVerse Scopus, RedALyC, CLASE, Red Iberoamericana de Revistas de Comunicación y Cultura, Latindex, SciELO México, Scielo Citation Index, HAPI, DOAJ.","palabras_clave":"RELEVANCIA|AGENDA|MÉTODO|IMPORTANCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":936,"idioma_id":4,"titulo":"Absence of environmental impact of the nematophagous fungus Duddingtonia flagrans used for control of gastrointestinal nematode in sheep","resumen":"Falta el abstrac","palabras_clave":"environmental impact|Duddingtonia flagrans"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":938,"idioma_id":5,"titulo":"Desequilibrios territoriales en la provincia de Santa Fe. Evolución e impactos de los procesos económicos de los últimos años","resumen":"La crisis del 2001 y el posterior abandono de la convertibilidad generaron un cambio del régimen macroeconómico que contribuyó a la recuperación de la economía nacional y regional. En los territorios  se produjeron modificaciones que aún no se han consolidado pero que mejoraron las condiciones de sostenibilidad económica y la calidad de vida de sus habitantes. En la provincia de Santa Fe, la situación  no es igual en todo el territorio provincial. Las realidades locales son diferentes por sus recursos, por los perfiles productivos y por las situaciones heredades o construidas en períodos anteriores. El trabajo  tiene como objetivo estudiar los desequilibrios territoriales de los departamentos que integran la  provincia de Santa Fe y analizar los procesos económicos que han tendido a modificarlos o profundizarlos. Se utilizan datos provenientes del Censo Nacional Económico 2004 y del Censo Nacional de Población y Vivienda de 1991, 2001 y 2010 e información de diferentes organismos nacionales y provinciales. Las disparidades intraprovinciales se explican, en parte, por las ventajas económicas y la disponibilidad de recursos en determinadas localizaciones que atraen nuevas inversiones, generando procesos concentradores acumulativos que sin decisiones políticas adecuadas acrecientan las diferencias sociales y las condiciones de vida de sus habitantes.","palabras_clave":"DESARROLLO|DESEQUILIBRIOS|PERFILES|ACUMULACIÖN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":939,"idioma_id":4,"titulo":"Crop monoculture rather than agriculture reduces the spatial turnover of soil bacterial communities at a regional scale","resumen":"The goal of this study was to investigate the spatial turnover of soil bacterial communities in response to environmental changes introduced by the practices of soybean monoculture or crop rotations, relative to grassland soils. Amplicon sequencing of the 16S rRNA gene was used to analyze bacterial diversity in producer fields through three successive cropping cycles within one and a half years, across a regional scale of the Argentinean Pampas. Unlike local diversity, which was not significantly affected by land use type, agricultural management had a strong influence on &#946;-diversity patterns. Distributions of pairwise distances between all soils samples under soybean monoculture had significantly lower &#946;-diversity and narrower breadth compared to distributions of pairwise distances between soils managed with crop rotation. Interestingly, good agricultural practices had similar degree of &#946;-diversity as natural grasslands. The higher phylogenetic relatedness of bacterial communities in soils under monoculture across the region was likely determined by the observed loss of endemic species, and affected mostly to phyla with low regional diversity, such as Acidobacteria, Verrucomicrobia and the candidates phyla SPAM and WS3. These results suggest that the implementation of good agricultural practices, including crop rotation, may be critical for the long-term conservation of soil biodiversity.","palabras_clave":"Microbial Ecology|No-till|Biotic homogeneization|Monocropping"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":940,"idioma_id":5,"titulo":"¿ES IMPORTANTE LA IGUALDAD POLÍTICA FORMAL?","resumen":"Una de las críticas más importantes a las democracias contemporáneas señala que si bien todos sus ciudadanos poseen derechos políticos iguales, laigualdad política es puramente formal. Dado que la objeción posee una fuerza normativa considerable, parecería claro que deberían aceptarse trueques entre la igualdad política formal y mejoras en la distribución económica.&nbsp; El objetivo del artículo es mostrar que tales trueques son irrazonables ya que la igualdad política puramente formal tiene un significado expresivo específico que no puede ser expresado de otra forma. El argumento que se utiliza para defender este objetivo tiene un carácter contractualista y señala que el valor de esta dimensión formal de la igualdad política consiste en la expresión de la igualdad moral de las personas de una forma única y en mostrar el debido respeto a la capacidad para un sentido de la justicia de los ciudadanos.","palabras_clave":"IGUALDAD MORAL|RESPETO|DEMOCRACIA|LIBERTADES POLITICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":941,"idioma_id":4,"titulo":"Role of ghrelin in fertilization, early embryo development, and implantation periods","resumen":"In order to clarify the physiological role of ghrelin in gestation, we evaluated the effects of administration of exogenous ghrelin  (2 or 4 nmol\/animal per day) or its antagonist (6 nmol\/animal per day of (D-Lys3)GHRP6) on fertilization, early embryo development,  and implantation periods in mice. Three experiments were performed, treating female mice with ghrelin or its antagonist: i) starting from  1 week before copulation to 12 h after copulation, mice were killed at day 18 of gestation; ii) since ovulation induction until 80 h later,  when we retrieved the embryos from oviducts\/uterus, and iii) starting from days 3 to 7 of gestation (peri-implantation), mice were killed  at day 18. In experiments 1 and 3, the antagonist and\/or the highest dose of ghrelin signi&#64257;cantly increased the percentage of atrophied  fetuses and that of females exhibiting this &#64257;nding or a higher amount of corpora lutea compared with fetuses (nCL\/nF) (experiment 3:  higher nCL\/nF-atrophied fetuses: ghrelin 4, 71.4?71.4% and antagonist, 75.0?62.5% vs ghrelin 2, 46.2K15.4% and control, 10?0.0%;  nZ7?13 females\/group; P!0.01). In experiment 2, the antagonist diminished the fertilization rate, and both, ghrelin and the antagonist,  delayed embryo development (blastocysts: ghrelin 2, 62.5%; ghrelin 4, 50.6%; and antagonist, 61.0% vs control 78.4%; nZ82?102  embryos\/treatment; P!0.0001). In experiment 3, additionally, ghrelin (4 nmol\/day) and the antagonist signi&#64257;cantly diminished the  weight gain of fetuses and dams during pregnancy. Our results indicate that not only hyperghrelinemia but also the inhibition of  the endogenous ghrelin effects exerts negative effects on the fertilization, implantation, and embryo\/fetal development periods,  supporting the hypothesis that ghrelin (in ?adequate? concentrations) has a physiological role in early gestational events.","palabras_clave":"REPRODUCTION|GHRELIN|FERTILIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":942,"idioma_id":5,"titulo":"Instituciones artificiales y sociabilidad natural el Vico","resumen":"El objetivo de este artículo es explicar la conexión entre instituciones artificiales y sociabilidad natural en la Ciencia nueva (1744) de Giambattista Vico. El artículo comienza con una breve reconstrucción de un aspecto del argumento de Vico contra Grocio. Luego es examinada la compatibilidad de la sociabilidad natural con el stato ferino. La conclusión es que en la concepción histórica de la naturaleza humana, formulada por Vico, la naturaleza humana está insertada en las instituciones del mundo civil.","palabras_clave":"Vico|instituciones|naturaleza humana|teoría política"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":943,"idioma_id":6,"titulo":"Réexamen de la méthodologie freudienne pour une recherche en psychanalyse aujourd'hui","resumen":"Revista indexada en SCOPUS, PASCAL, PsycINFO, Zeitschriftendatenbank, German Journal Database ZDB (Alemania), entre otras. Incluida en la lista de revistas recomendadas por la Agence d´Evaluation de la Recherche et de l´Enseignement Supérieur (AERES)RESUMEL´article s´inscrit dans le champ plus vaste de la méthodologie de la recherche dans les sciences humaines et propose une réflexion sur l´apport freudien à partir de l´examen de quelques énoncés concernant les différences entre la position du chercheur et la position de l´analyste. Cette réflexion permet de faire une lecture des pas que Freud reconnaît dans son travail de recherche et propose aussi comme problématique l´inclusion de l´inconscient dans l´activité du chercheur. Qu´est-ce que l´analyste fait quand il fait de la recherche ? Se sert-il de son inconscient comme instrument de recherche? Fait-il confiance au domaine de l´inconscient dans l´élaboration de la trame ? L´inclusion de la dimension de l´inconscient dans la réflexion sur la méthodologie de la recherche en psychanalyse permet de repenser les possibles « points aveugles » du chercheur, qui apparaissent sous la forme des présuppositions et préjugés. Cette inclusion éclaire aussi une autre dimension de la recherche : celle de l´originalité apparente des découvertes. L´article propose comme conclusion que l´analyste chercheur introduit une nouvelle conception de l´objectivité dans la recherche : celle d´une subjectivité critiquée qui considère le rôle de l´inconscient du chercheur dans la production de la connaissance.  ","palabras_clave":"RECHERCHE|METHODE|FREUD|SUBJECTIVITE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":944,"idioma_id":5,"titulo":"Responsabilidad del psicólogo en investigación con participantes vulnerables. El caso de los niños y las niñas.","resumen":"El propósito de este trabajo es presentar parte del marco conceptual del proyecto de investigación ?Responsabilidad científica en investigación con humanos: un estudio sobre las perspectivas de los alumnos de Psicología de la Universidad Nacional de La Plata?. Dicho estudio relevará las perspectivas y opiniones de estudiantes del ciclo superior de la Licenciatura en Psicología sobre la ética científica y la responsabilidad en investigación con humanos.  Se realiza un análisis del concepto de responsabilidad, contemplando su significación etimológica y abordando la dimensión intersubjetiva y pública de un acto profesional responsable en su sentido ético y jurídico. A continuación, se analiza la responsabilidad del científico en encuadre de investigación social en general, y psicológica en particular, sobre la base de documentos internacionales de derechos humanos y principios éticos para la investigación, especialmente para el caso de sujetos en condiciones de relativa autonomía o de vulnerabilidad. Finalmente, se presentan los principios éticos para la investigación psicológica con niños y niñas y sus adecuaciones necesarias.  Consideramos que la reflexión y las capacidades ético-deontológicas forman parte importante en la formación de grado de los futuros profesionales, y que este tipo de investigaciones puede contribuir al fortalecimiento de prácticas científico-profesionales más justas y responsables.","palabras_clave":"RESPONSABILIDA|INVESTIGACION|AUTONOMIA|VULNERABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":945,"idioma_id":5,"titulo":"Territorio y actores políticos en el proceso de regionalización de la Provincia de Santa Fe. Una disputa por los 'caminos de la gente'.","resumen":"El presente artículo analiza el proceso de regionalización y de planificación estratégica participativa implementado por el gobierno de la provincia de Santa Fe (Argentina) en la primera etapa, de 2008 a 2012. Por tratarse de una política novedosa para el país y la región, en un primer momento se realiza una descripción de sus objetivos y consecuencias en términos de la reorganización de los territorios. En un segundo momento, se abordan las implicancias de la política de regionalización desde la perspectiva de los actores territoriales interpelados: los senadores provinciales y las autoridades ejecutivas locales intendentes y presidentes comunales).  A lo largo del trabajo se abordan dos tensiones fundamentales que pueden orientar el estudio de procesos semejantes en otros contextos subnacionales. La primera involucra a los senadores departamentales que disponen de la legitimidad otorgada por el proceso electoral y que a causa de la implementación de la regionalización se ven obligados a convivir con espacios alternativos para la canalización y representación de las demandas ciudadanas localizadas en sus respectivos territorios políticos. La segunda incluye a las autoridades ejecutivas locales, legitimadas también por el voto popular de sus municipios y comunas, y las autoridades delegadas por el Poder Ejecutivo provincial,  que se instalan en las nuevas jurisdicciones.","palabras_clave":"REGIONALIZACIÓN|REPRESENTACIÓN|TERRITORIO|PLANIFICACIÓN ESTRATÉGICA PARTICIPATIVA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":946,"idioma_id":4,"titulo":"INFLUENCE OF SOYBEAN FLOUR ON FATTY ACIDS PROFILE IN THE LIVER OF RATS FED WITH NORMOCALORIC AND HYPERCALORIC DIETS","resumen":"The diet fatty acids composition is known to influence the fatty acid composition of stored and structural lipids inthe body .This study investigates the effects of replacing casein with soybean flour on the fatty acids profile in theliver of Wistar male rats that were previously fed with normocaloric and hypercaloric diets based on casein. Onegroup was fed with control diet and another with hypercaloric diet (with 34.15% sucrose, 42% fat calories) for 9weeks. Each group was then divided into two subgroups and casein was replaced with soybean in one of them,obtaining: CC (control casein), CS (control soy), HC (hypercaloric casein) and HS (hypercaloric soy), which werefed for 6 weeks. Capillary gas-liquid chromatography (c-GLC) of the fatty acid methyl esters (FAME) wasperformed.The analysis of the fatty acid profiles in rat liver, showed that replacing the casein diets by a vegetableprotein, such as soybean flour, induces an increase of unsaturated fatty acids and a decrease of saturated ones (P <0.01), even with the hypercaloric diets. There was a clear decrease in lauric, myristic and palmitic acids in liver ofrats fed with soy. The unsaturated : saturated fatty acids ratio (unsat : sat), increased in both soy diets comparedwith casein. This allows us to assume that soybean flour, even in hypercaloric diets, would have a positive effect onthe prevention of simple steatosis. The total omega-6 polyunsaturated fatty acids (PUFA n-6) was significantlyhigher in the CS and HS groups compared to the casein groups (P < 0.01). Similar behavior was observed in totalomega-3 polyunsaturated fatty acids (PUFA n-3), and a lower n-6 : n-3 ratio was observed in soy groups comparedto casein groups, exerting a positive effect in preventing many diseases, including: cardiovascular disease,inflammatory and autoimmune diseases.We believe that consumption of soybean flour (whole grain) is a very gooddietary resource for improving hepatic fatty acid profile, and therefore, have a beneficial health effect.","palabras_clave":"Soybeans|Fatty Acids"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":947,"idioma_id":5,"titulo":"La cuestión de la autoridad en el proceso formativo de estudiantes del Profesorado de Ciencias Jurídicas. Desafíos de la formación docente universitaria","resumen":"El presente artículo se propone plantear los principales ejes de análisis y primeras hipótesis del proyecto Ubacyt ?La formación docente universitaria como espacio de configuración de la identidad profesional: la cuestión de la autoridad en el proceso formativo?, que lleva adelante el equipo de cátedra de la materia Aspectos organizacionales y administrativos de la educación argentina, del Profesorado de Ciencias Jurídicas, Facultad de Derecho, UBA.","palabras_clave":"formación docente universitaria|autoridad pedagógica|identidad profesional"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":948,"idioma_id":5,"titulo":"Calidad bacteriológica del agua del río San Juan en zonas aledañas a la desembocadura del arroyo los tapones (San Juan, Argentina)","resumen":"En este trabajo se propone: a) determinar la presencia de Escherichia coli, Shigella spp. y Salmonella spp. en el agua del río San Juan recolectada aguas arriba de la desembocadura del arroyo Los Tapones (Sitio 1) y en su confluencia con el río mencionado (Sitio 2); b) correlacionar las variaciones en la densidad de las poblaciones bacterianas entre sí y con las variaciones en el caudal y la temperatura del agua del río. En cada sitio se tomaron dos muestras de agua y su temperatura (diciembre 2008?noviembre 2009). Se determinó la presencia de E. coli en ambos sitios, no detectándose diferencias significativas entre ellos. Las densidades poblacionales de Shigella y Salmonella, en el Sitio 1 fueron significativamente menores (P= 0,0358 y P= 0,0045 respectivamente) que las encontradas en el Sitio 2. Las poblaciones de E. coli se correlacionaron positivamente con las bacterias del género Salmonella (P= 0,04) y Shigella (P= 0,03). Además, se encontró una correlación positiva entre las variaciones poblacionales de Salmonella con la temperatura del agua (P= 0,01), mientras que las de Shigella correlacionaron en forma inversa con el caudal (P= 0,02). Estos resultados señalarían el deterioro de la calidad del agua del río San Juan.","palabras_clave":"CONTAMINACIÓN|SALMONELLA|SHIGELLA|SAN JUAN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":949,"idioma_id":5,"titulo":"Estimación del Rendimiento de Soja y Maíz basado en el Índice de Vegetación de Diferencia Normalizada (NDVI)","resumen":"La información confiable y anticipada de rendimiento de los cultivos tiene influencia enla gestión de actividades de cosecha, almacenamiento, transporte y comercialización.La producción de cultivos extensivos es el principal uso de las tierras agrícolas en la zona central de Argentina y una fuente importante de ingresos económicos. En particular la soja y el maíz son los principales cultivos estivales realizados en la provincia de Córdoba. El objetivo de este trabajo fue desarrollar modelos simples que permitan estimar rendimientos de soja y maíz antes de la cosecha, a partir del NDVI obtenido de imágenes satelitales Landsat y SPOT. Para la construcción y validación delos modelos se relevaron lotes con soja y maíz, en la campaña 2013\/2014, y se obtuvieron los rendimientos. Los modelos de regresión lineal desarrollados con NDVI presentaron muy buenos estadísticos de ajuste, R2=0,96 para soja y R2=0,81 para maíz.","palabras_clave":"cultivos agrícolas|rendimiento|modelos|imágenes satelitales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":953,"idioma_id":4,"titulo":"Towards an ontology for product version management","resumen":"During its lifecycle, products are affected by market, technology, and user requirements. Without a process for efficiently handling product changes, product data, which is spread in different areas and systems, might become unusable, incomplete, or inconsistent. A simple change on product information may trigger a domino effect that could be very difficult to control. In order to reduce this effect, knowledge is important to answer what, when, why, and how a change occurred. This article proposes an ontology that allows capturing product changes in order to answer the aforementioned questions. The proposed ontology extends PRoductONTOlogy (PRONTO) (Vegetti et al., 2011) to represent product family changes. OWL implementation of the proposed ontology is presented with a simple case study to validate it.","palabras_clave":"PRODUCT LIFECYCLE MANAGEMENT ONTOLOGY|ONTOLOGY|PRODUCT VERSION|PRODUCT ONTOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":954,"idioma_id":4,"titulo":"Histopathological biomarkers in juvenile silver catfish (Rhamdia quelen) exposed to a sublethal lead concentration","resumen":"The aimofthisstudywastodeterminethe96-hlethalconcentration(96-hLC50)oflead(Pb)insilver  catfish, Rhamdia quelen, andtodeterminehistopathologicalbiomarkersin fish exposedfor96-htoa  sublethal concentrationat25%oftheLC50.The96-hLC50was108mg L  1. Ingills,thelengthand  thickness oflamellaandthicknessofthe filament epitheliumweresignificantly higherin fish exposedto  Pb for48-hthanincontrol fish whereastheinterlamellardistancedecreased.Intheliver,theareaoc-  cupied bylipiddropletsandsizeofhepatocytesshowedsignificantly highervaluesafter24-hofex-  posure. Thepercentageofabnormalrenaltubuleswashigherin fish exposedtoPb,exhibitingatime-  dependent increase.Thesevariationsinhistopathologicalbiomarkerspermitthedefinition oftheoverall  response of R. quelen to PbandthepotentialusefulnessinthemonitoringofPbcontamination.","palabras_clave":"LEAD|HISTOPATHOLOGY|RHAMDIA QUELEN|ACUTE TOXICITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":955,"idioma_id":4,"titulo":"The Relationship Between Facial Shape Asymmetry and Attractiveness in Mexican Students","resumen":"Objectives: It has been postulated that symmetric faces are considered more attractive than asymmetric ones because symmetry may signal high quality due to developmental stability. However, other studies showed that both symmetric and slightly asymmetric faces are considered attractive. Here we aim to explore this discrepancy, beginning with the analysis of the normal prevalence of facial symmetry in a population as a necessary first step prior to any attractiveness assessment. Methods: We collected facial landmarks from two-dimensional digital images of a sample of Mexican individuals (280 females and 285 males aged 18?68 years) that were analyzed using geometric morphometric methods. Then, we chose a subsample of 100 photographs (50 females and 50 males aged 18?27 years) selected to represent a broad range of asymmetrical variation, in order to evaluate attractiveness using a sex-opposite test. Finally, we analyzed the linear correlation between attractiveness and asymmetry. Results: We found that every evaluated subject presents some degree of facial asymmetry, and that both fluctuating asymmetry and directional asymmetry were significant (P < 0.0001) components of total facial asymmetry. Fluctuating asymmetry was slightly associated with age (r 5 0.0858, P 5 0.0414) and there were no differences between geographical regions (P 5 0.413). Attractiveness was not correlated to levels of asymmetry in either sex (males: P 5 0.0973; females P 5 0.7415). Conclusions: Asymmetry was a prevalent feature in the present sample, and preferences for symmetric faces were  not operating in the studied population.","palabras_clave":"FACIAL SHAPE ASSIMETRY|GEOMETRIC MORPHOMETRIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":958,"idioma_id":5,"titulo":"Dilemas de justicia y justificación. Una aproximación a conflictos de valor en la asistencia estatal","resumen":"El artículo analiza las prácticas de asignación de beneficios de agentes estatales pertenecientes al Ministerio de Desarrollo Social de la Nación en la Argentina de la última década. Sobre la base del trabajo de campo etnográfico en dicho organismo, se reconstruyen las pragmáticas de justificación que contienen dichas prácticas y los conflictos de valor que plantean. Se muestran las dificultades que encuentran los agentes estatales para acordar principios de justificación que permitan eludir en simultáneo acusaciones potenciales de discrecionalidad, por un lado, e indiferencia, por el otro. Argumentamos que esta dificultad permite comprender los modos específicos, a menudo extra-programáticos, en que se regula cotidianamente la asignación de beneficios. En particular, mostramos que estos conflictos de valor están en la base de cierto privilegio que los agentes otorgan a la interacción directa con los receptores de recursos, es decir, al desplazamiento al terreno. Desde una mirada centrada en el nivel capilar de las políticas, el artículo intenta contribuir al conocimiento de las condiciones en las cuales se ejerce la autoridad asistencial del Estado","palabras_clave":"AGENTES ESTATALES|ASISTENCIA SOCIAL|MICRO-ENCUENTROS BUROCRÁTICOS|JUSTIFICACIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":959,"idioma_id":5,"titulo":"Peronismo, agro y tecnología agropecuaria. La reconfiguración del INTA (1973-1976)","resumen":"Este artículo aborda el proceso de reconfiguración institucional del Instituto Nacional de Tecnología Agropecuaria (INTA) a partir de 1973 -en coincidencia con el retorno del peronismo al gobierno- y los conflictos desarrollados en su interior. Con el objetivo de reconstruir y analizar la situación del instituto entre 1973 y 1976, se desarrollan cuatro apartados. La introducción presenta una trayectoria histórica del organismo, y contextualiza sus principales rasgos. El segundo apartado introduce la problemática de la conformación de nuevos equipos de gobierno en 1973 en los diferentes organismos estatales, con miras al sector agropecuario. El tercero explora la organización de la conducción del INTA en este período, su trayectoria y las tensiones presentes en el organismo. El cuarto analiza el tramo final de este período, atravesado por una intervención del instituto dispuesta por el Poder Ejecutivo en 1975, continuada un año después por la intervención militar que inicia con motivo del último golpe de Estado.   A la luz de transformaciones políticas y socio-económicas, se explora la trayectoria del INTA en base a documentos institucionales, fondos documentales del archivo de la ex Dirección de Inteligencia de la Policía de la Provincia de Buenos Aires (DIPBA), entrevistas y prensa gráfica del período.","palabras_clave":"Peronismo|Agro|Tecnología agropecuaria|INTA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":961,"idioma_id":5,"titulo":"ROL DEL ASISTENTE DENTAL EN LA ATENCION DE PACIENTES CON SINDROME DE DOWN","resumen":"?ODONTOLOGIA Y DISCAPACIDAD, DERRIBANDO BARRERAS? publicado en la revista de la Catedra CLINICA DEL PACIENTE DISCAPACITADO, ?SONRISAS ESPECIALES? de la Facultad de odontología de la Universidad Nacional de Cuyo, Pags. 2 a 4, AÑO 5 Numero I  ISSN 2314-1026. Diciembre 2015","palabras_clave":"ODONTOLOGÍA|DISCAPACIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":962,"idioma_id":4,"titulo":"Observation and measurements of the production of prompt and non-prompt J\/&#968; mesons in association with a Z boson in pp collisions at s&#8730; = 8 TeV with the ATLAS detector","resumen":"The production of a Z boson in association with a J\/&#968;   meson in proton--proton collisions probes the production mechanisms of   quarkonium and heavy flavour in association with vector bosons, and   allows studies of multiple parton scattering. Using 20.3 fb&#8722;1 of data collected with the ATLAS experiment at the LHC, in pp collisions at s&#8730;=8 TeV, the first measurement of associated Z+J\/&#968; production is presented for both prompt and non-prompt J\/&#968; production, with both signatures having a significance in excess of 5&#963;. The inclusive production cross-sections for Z boson production (in &#956;+&#956;&#8722; or e+e&#8722; decay modes) in association with prompt and non-prompt J\/&#968;(&#8594;&#956;+&#956;&#8722;) are measured relative to the inclusive production rate of Z bosons in the same fiducial volume to be (88±16±6)×10&#8722;8 and (157±22±10)×10&#8722;8 respectively. Normalised differential production cross-sections are also determined as a function of the J\/&#968;   transverse momentum. The fraction of signal events arising from single   and double parton scattering is estimated, and a lower limit of 5.3&nbsp;(3.7) mb at 68&nbsp;(95)% confidence level is placed on the effective cross-section regulating double parton interactions.    ","palabras_clave":"HIGH ENERGY|EXPERIMENT |ATLAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":963,"idioma_id":4,"titulo":"Observation and measurement of Higgs boson decays to WW&#8727; with the ATLAS detector","resumen":"We report the observation of Higgs boson decays to WW&#8727;   based on an excess over background of 6.1 standard deviations in the   dilepton final state, where the Standard Model expectation is 5.8   standard deviations. Evidence for the vector-boson fusion (VBF)   production process is obtained with a significance of 3.2 standard   deviations. The results are obtained from a data sample corresponding to   an integrated luminosity of 25pb&#8722;1 from s&#8730;=7 and 8 TeV pp   collisions recorded by the ATLAS detector at the LHC. For a Higgs boson   mass of 125.36 GeV, the ratio of the measured value to the expected   value of the total production cross section times branching fraction is 1.09+0.16&#8722;0.15(stat.)+0.17&#8722;0.14(syst.). The corresponding ratios for the gluon fusion and vector-boson fusion production mechanisms are 1.02±0.19(stat.)+0.22&#8722;0.18(syst.) and 1.27+0.44&#8722;0.40(stat.)+0.30&#8722;0.21(syst.), respectively. At s&#8730;=8 TeV, the total production cross sections are measured to be &#963;(gg&#8594;H&#8594;WW&#8727;)=4.6±0.9(stat.)+0.8&#8722;0.7(syst.)pb and &#963;(VBFH&#8594;WW&#8727;)=0.51+0.17&#8722;0.15(stat.)+0.13&#8722;0.08(syst.)pb.   The fiducial cross section is determined for the gluon-fusion process   in exclusive final states with zero or one associated jet.  ","palabras_clave":"HIGH ENERGY|EXPERIMENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":965,"idioma_id":5,"titulo":"'Susceptibilidad Antibiótica de Estafilococos aislados de muestras de leche provenientes de Mastitis Bovina.'","resumen":"La mastitis  es una enfermedad que afecta la salud de los bovinos y produce grandes pérdidas  económicas. Los microorganismos  de mayor prevalencia en la Argentina pertenecen al género Staphylococcus, siendo el patógeno principal S. aureus, aunque los  estafilococos coagulasa negativos (ECN) han adquirido importancia por la  capacidad de expresar factores de virulencia y resistencia a antimicrobianos. El objetivo de este estudio fue determinar in vitro la concentración inhibitoria  mínima (CIM) de betalactámicos y macrólidos-lincosamidas frente a estafilococos  aislados de leche de  vacas con mastitis. Se estudiaron (n=162) aislamientos, (n=65) S. aureus y (n=97) ECN. El 33,8% (22\/65)  de S. aureus  presentó resistencia a penicilina, siendo la CIM90:  0,5 µg\/ml, el 7,7% (5\/65) a eritromicina con una CIM90: 1 µg\/ml y el  6,1% (4\/65)  a clindamicina con una CIM90:  0,1 µg\/ml. El 30,9% (30\/97) de los ECN fueron resistentes a penicilina siendo  la CIM90: 0,25 µg\/ml, el 7,2% (7\/97) a eritromicina con una CIM90:  0,5 µg\/ml, el 4,1% (4\/97) a clindamicina con una CIM90: 0,12 µg\/ml y  el 3,1% (3\/97) a oxacilina siendo la CIM90: 0,38 µg\/ml.  No se observó meticilino resistencia en S. aureus. El diagnóstico bacteriológico y la determinación de  susceptibilidad junto con el manejo adecuado del rodeo lechero, son fundamentales  para el control de la enfermedad.      Palabras clave: (concentración inhibitoria mínima), (mastitis bovina), (resistencia),  (Staphylococcus spp) ","palabras_clave":"CONCENTRACION INHIBITORIA MINIMA|MASTITIS BOVINA|RESISTENCIA|STAPHYLOCOCCUS SPP."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":966,"idioma_id":5,"titulo":"Voluntariado Educación Exacta","resumen":"La educacion como pilar fundamental para el desarollo, debe ser apoyada por los diferentes estamentos de la sociedad, propiciando la participacion voluntaria en esquemas de enseñanza hacia todas las personas y en todos los niveles educativos, generando canales de apoyo a los alumnos.","palabras_clave":"voluntariado|educacion|extension|exacta"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":967,"idioma_id":5,"titulo":"Avanza hacia el conocimiento cientifico - Experiencias educativas cientificas. Dinamicas sociales del conocimiento cientifico tecnologico","resumen":"Avanza hacia el conocimiento cientifico, es un articulo, donde se describen posibilidades de llegar con los conocimientos cientificos tecnologicos a la sociedad en su conjunto, mediante la capacidad innovativa de docentes y alumnos de las carrreras de ingenieria de la Facultad de Ciencias Exactas y Naturales y Agrimensura","palabras_clave":"experiencias|educativas|cientificas|tecnologicas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":968,"idioma_id":4,"titulo":"Internal Structure Analysis of Polypropylene\/Quartz Composites Related to Their Toughness","resumen":"The mechanical performance of composite materials has been related to a wide range of   factors. The complexity of analysis lays on the fact that any single variation normally affects many   characteristics or properties of the composite material. For this reason, different theoretical and   experimental characterizations should be considered.  In this work the internal structure, interactions and fracture surfaces of PP based composites   reinforced with quartz particles are investigated. Particle size distributions, rheological measurements   and multifractal spectra suggest favorable filler dispersion into the PP matrix. A yield strength model   and rheological data evidence low internal interactions. In addition, these composites characteristics   could promote the effective activation of energy consumption mechanisms improving the material   toughness. The fracture surfaces analysis allows correlating fractography, multifractal spectra and   material toughness. However, the experimental procedure of multifractal theory should be improved   to define the most sensitive parameter for fractographic studies","palabras_clave":"polypropylene|mechanical properties|composites"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":972,"idioma_id":4,"titulo":"IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis","resumen":"Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent Mtb in macrophage cell lines. We investigated the contribution of autophagy to the defense against Mtb antigen (Mtb-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against Mtb-Ag; and low responders (LR) when patients showed weak or no T cell responses to Mtb-Ag. The highest autophagy levels were detected in HD cells whereas the lowest quantities were observed in LR patients. Interestingly, upon Mtb-Ag stimulation, we detected a positive correlation between IFNG and MAP1LC3B-II\/LC3-II levels. Actually, blockage of Mtb-Ag-induced IFNG markedly reduced autophagy in HR patients whereas addition of limited amounts of IFNG significantly increased autophagy in LR patients. Therefore, autophagy collaborates with human immune responses against Mtb in close association with specific IFNG secreted against the pathogen.","palabras_clave":"TUBERCULOSIS|AUTOPHAGY|INTERFERON GAMMA|CYTOKINES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":973,"idioma_id":4,"titulo":"Role of AtMSH7 in UV-B-induced DNA damage recognition and recombination","resumen":"The mismatch repair (MMR) system maintains genome integrity by correcting replication-associated errors and inhibiting recombination between divergent DNA sequences. The basic features of the pathway have been highly conserved throughout evolution, although the nature and number of the proteins involved in this DNA repair system vary among organisms. Plants have an extra mismatch recognition protein, MutS&#947;, which is a heterodimer: MSH2\/MSH7. To furtherunderstand the role of MSH7 in vivo, we present data from this protein in Arabidopsis thaliana. First, we generated transgenic plants that express &#946;-glucuronidase (GUS) under the control of the MSH7 promoter. Histochemical staining of the transgenic plants indicated that MSH7 is preferentially expressed in proliferating tissues. Then, we identified msh7 T-DNA insertion mutants. Plants deficient in MSH7 show increased levels of UV-B-induced cyclobutane pyrimidine dimers relative to wild-type (WT) plants. Consistent with the patterns of MSH7 expression, we next analysed the role of the protein during somatic and meiotic recombination. The frequency of somatic recombination between homologous or homeologous repeats (divergence level of 1.6%) was monitored using a previously described GUS recombination reporter assay. Disruption of MSH7 has no effect on the rates of somatic homologous or homeologous recombination under control conditions or after UV-B exposure. However, the rate of meiotic recombination between two genetically linked seed-specific fluorescent markers was 97% higher in msh7 than in WT plants. Taken together, these results suggest that MSH7 is involved in UV-B-induced DNA damage recognition and in controlling meiotic recombination.","palabras_clave":"Arabidopsis thaliana|meiotic recombination|mismatch repair|mitotic recombination|sequence divergence|UV-B radiation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":974,"idioma_id":5,"titulo":"Las TIC en la educación media: ¿una herramienta más o nuevo contexto de aprendizaje? Análisis de las representaciones de docentes y directivos sobre el Programa Conectar Igualdad en tres provincias de la Patagonia Argentina","resumen":"En este artículo se analizan resultados parciales de un estudio más amplio que tuvo como objetivo evaluar el impacto del Programa Conectar Igualdad en tres provincias (La Pampa, Río Negro y Neuquén) de la Patagonia Argentina. El Programa Conectar Igualdad se comenzó a implementar hacia fines del año 2010 y su objetivo central fue la inserción de Tecnologías de la Información y la Comunicación (TIC) en las escuelas públicas de enseñanza media de todo el país. Implicó en primera instancia la entrega de tres millones de notebooks a alumnos y docentes bajo el paradigma del modelo 1 a 1.  El objetivo del presente trabajo es presentar algunos de los hallazgos resultantes de las entrevistas realizadas en el año 2011 a docentes y directivos de nivel medio, donde se indagó sobre la representación que tenían los mismos del Programa Conectar Igualdad y de la introducción de las TIC en las aulas. La investigación incluyó el relevamiento de datos en 21 escuelas (7 escuelas de cada una de las tres provincias). La técnica de recolección de datos cualitativa que se utilizó fue la entrevista, realizándose 150 entrevistas a docentes y directivos. Las conclusiones de este trabajo constituyen un insumo para la evaluación y el rediseño de políticas públicas de inclusión de TIC en educación en los países de la región.","palabras_clave":"EVALUACIÓN DE POLÍTICAS PÚBLICAS|POLÍTICAS PUBLICAS DE INCLUSIÓN DIGITAL|PROGRAMA CONECTAR IGUADAD|TECNOLOGÍAS DE LA INFORMACIÓN Y LA COMUNICACIÓN|SOCIOLOGÍA DE LA TECNOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":976,"idioma_id":5,"titulo":"Políticas de comunicación y la producción de contenidos audiovisuales en Argentina 2011-2013","resumen":"      Desde la perspectiva de la economía política de la comunicación, el  trabajo analiza las políticas de comunicación para fomentar la producción de contenidos  audiovisuales en el marco de la sanción de la Ley de Servicios de Comunicación  Audiovisual 26.522 y la implementación de la televisión digital terrestre.      Durante el periodo  2010-2013 se realizaron concursos en el marco del Plan Operativo de Fomento y  Promoción de Contenidos Audiovisuales Digitales, promovidos por el Estado.  Entre los hallazgos del análisis se destaca la entrada de nuevos actores en la  cadena de valor, con intentos por desmontar la lógica centro-periferia que  predomina en la televisión argentina. Y, por otro lado, un impulso convergente  en la fase de consumo.   ","palabras_clave":"POLITICAS DE COMUNICACION|TELEVISION DIGITAL|PRODUCCION DE CONTENIDOS|ESTADO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":977,"idioma_id":4,"titulo":"Mesothelioma mortality in Argentina 1990-2010","resumen":"Objectives To estimate the number of cases and proportionate mesothelioma mortality in Argentina over the period of 1990?2010.Method Data are from death certificates, Mortality Database (DEIS), Health Ministry of Argentina. Mesothelioma was defined using the following codes of the International Classification of Diseases, 9th Rev. 151, 161\/2, 164, 195, 199, 212, 229, 235, 495, 500\/04, 511, used from 1990?1997; and ICD-10th Rev. codes J60, J90, C32, C45, from 1998 through 2010. Proportional mortality was estimated for each calendar year.Results A total of 1734 of mesothelioma deaths were reported, varying widely, from 99 in 1995 to 16 in 1997. There was an increasing (44.0%) trend of deaths overtime. The proportionate mesothelioma mortality in 1990 was 0.3\/1000 and showed a linear declining trend until 0.01\/1000 in 2010.Conclusions Argentina ban extraction, production, and the asbestos trade in 2001 but little is known about its impact or prospects on workers? health. The number of mesothelioma deaths is growing and it is plausible to continue to increase given its long latency period. Argentinian occupational health and safety authorities need to implement a national surveillance system capable to monitor risk factors and health outcomes for better planning and commitment with workers? health and wellbeing.","palabras_clave":"Mesotelioma|Tendencia Temporal|Mortalidad|Asbestos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":979,"idioma_id":5,"titulo":"Acción económica e incertidumbre: el aporte de Jens Beckert a la sociología económica","resumen":"A partir del análisis de las limitaciones que impone la incertidumbre al modelo de acción racional, Jens Beckert, figura central de la nueva sociología económica, propone una teoría sociológica de la acción económica centrada en el concepto de racionalidad intencional. Ante la incapacidad de realizar cálculos a priori, los actores se apoyan en dispositivos sociales como las expectativas ficticias, que ofrecen ?ilusiones de realidad? que facilitan la acción. El artículo propone un acercamiento a los fundamentos de la teoría de la acción económica del autor.","palabras_clave":"Sociología económica|Jens Beckert|acción racional|Incertidumbre"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":980,"idioma_id":5,"titulo":"La educación odontológica en el contexto de la Universidad Nacional de Córdoba, Argentina.","resumen":"La educación es una práctica que toda sociedad realiza con el propósito de reproducirse y transformarse a través del tiempo. Implica la opción por una determinada racionalidad, es decir, por determinados y específicos modos de pensar y actuar elaborados a partir de una concepción del hombre, del conocimiento y los valores socialmente significativos. Por ello, descifrar qué es la educación, implica una construcción de sentido desde concepciones antropológicas, gnoseológicas y axiológicas elaboradas (o adoptadas) por cada grupo social.  Esta construcción de sentido, en nuestros días se torna un tanto más dificultosa, por tratarse de tiempos de transición, tiempos en que se agotan visiones del mundo, de la ciencia, del hombre y valores hasta ahora vigentes y surgen nuevas visiones que aún no sabemos como impactarán en el sujeto individual y en la sociedad. Atravesamos una época caracterizada por la coexistencia de dos maneras de mirar y comprender al mundo: la modernidad y la post modernidad, lo que hace que convivan diferentes paradigmas, así, están quienes se aferran a los conceptos, y con ello intentan demorar los cambios, y aquellos que considerando indiscutible el quiebre conceptual de la racionalidad moderna, se lanzan al diseño de un mundo post moderno.  De modo que nos toca vivir un tiempo de redefiniciones profundas, lo que lo hace particular y complejo. En relación a la educación, la crisis modernidad - post modernidad y las nuevas categorías conceptuales derivadas de esta última han impactado en las Instituciones Educativas despojándolas de sus tradicionales ejes de discusión y trabajo, lo que las ha sumido en un estado de desconcierto, inseguridad, falta de certeza de cuáles deben ser los objetivos educativos prioritarios. (1)","palabras_clave":"Educación|Odontología"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":982,"idioma_id":5,"titulo":"Punto de vista y variación: la configuración del saber en el Libro de los estados de don Juan Manuel","resumen":"El Libro de los Estados (c. 1328, según MacPherson y Tate y 1332 en opinión de J. M. Blecua) se organiza, como otros textos de don Juan Manuel, a partir de una estructura dialogal. Es en el marco de esta estructura dialogal donde se dirimen las complejas relaciones entre saber y poder que se configuran en el texto dramatizadas por distintos personajes: el rey, el infante Joas, un caballero de nombre Turín y el filósofo Julio, relaciones que, por otra parte, conocerán reelaboraciones en el Libro del Conde Lucanor (c. 1335) y el Libro infinido (c. 1336-1337). El temor la desconfianza y la prueba organizan no sólo los vínculos entre estos personajes sino que definen asimismo las concepciones del saber y el poder.","palabras_clave":"LITERATURA ESPAÑOLA MEDIEVAL|DON JUAN MANUEL|NARRATOLOGÍA|PUNTO DE VISTA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":983,"idioma_id":5,"titulo":"La angustia y la palabra. H. P. Lovecraft según Alberto Breccia","resumen":"Breccia retoma desde el lenguaje de la historieta una de las grandes cuestiones para el arte del siglo XX: ¿cómo representar lo irrepresentable? Breccia lo hace desde los intersticios que ese cultura le ha dejado a la historieta, conjugando un entretenimiento recuperado como actitud fundamental para consolidarse como autor desde dentro de la industria cultural de masas.","palabras_clave":"BRECCIA|LOVECRAFT|IRREPRESENTABLE|HISTORIETA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":984,"idioma_id":4,"titulo":"Zooarchaeology in the Paraná river floodplain:  GIS implementation at a regional scale","resumen":"The aim of this study is to evaluate the use of wildlife resources that human populations which inhabited the Paraná River floodplain during the late Holocene carried out. To that end, zoo archaeological information from 26 archaeological sites analyzed by different research teams was collected. In order to perform the analysis of the composition of the sets, a Geographic Information System (GIS) is used, since this tool facilitates the comparison between the representations of the different taxa spatially and temporally. This allows us to establish similarities and differences in the use of wildlife resources carried out by the groups of hunters, gatherers and fishers in the region.Most of the zooarchaeological analyses are performed at a micro-regional level; however, due to the fact that this study is developed at a regional scale, it enables a comprehensive understanding of the structure of the different archaeofaunal assemblages in the diverse landscape units which make up the Parana River floodplain. The application of the GIS to this analysis provides simple graphics to visualize and interpret data and its variations in terms of space.","palabras_clave":"zooarchaeology|regionale scale|GIS|Paraná River"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":986,"idioma_id":5,"titulo":"Coeficiente de difusión en semillas de Amaranthus cruentus rehumectadas","resumen":"El objetivo del presente trabajo fue estimar experimentalmente los coeficientes de difusión efectivos de agua en semillas de amaranto rehumectadas para posteriores estudios del rendimiento y calidad del popeado o reventado del grano. Las semillas se rehumectaron por inmersión en agua a temperaturas de 11, 35 y 50 °C durante intervalos de tiempo de 0.5, 1, 2 y 4 h, determinándose gravimétricamente la humedad adquirida en cada condición estudiada. Para estimar el coeficiente de difusión se empleó el modelo difusional basado en la solución analítica de la  segunda ley de Fick, considerando a la semilla de amaranto como una esfera de radio 0.6 mm. Se midieron las humedades de equilibrio en las condiciones estudiadas luego de un tiempo de 24 h de rehumectación. Los resultados obtenidos fueron similares a los encontrados por otros autores para semillas de quinua y otras variedades de amaranto, con características semejantes. Los valores de los coeficientes de difusión efectivos aumentaron con el incremento de la temperatura.","palabras_clave":"Amaranto|Rehumectación|Difusión|Modelo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":987,"idioma_id":4,"titulo":"Switching nuclearity and Co(II) content through stoichiometry adjustment: {CoII6CoIII3} and {CoIICo4III} mixed valent complexes and a study of their magnetic properties","resumen":"We are reporting two new mixed valent Co(II)\/Co(III) polynuclear complexes, {CoII6CoIII3} and {CoIICoIII4},bearing different amount of Co(II) ions in their cores, through the employment of the multidentate triethanolamine (teaH3) ligand in different stoichiometric ratios. We present a complete picture of the magnetic behaviour of both complexes through a combined usage of the susceptibility, magnetization and X-band EPR data as well as broken-symmetry DFT calculations. Compound 1 shows an atypical spin-only behaviour, probably due to the presence of four and five coordinated Co(II) sites as well as highly distorted six coordinated Co(II) ions, promoting a high degree of orbital contribution quenching. Through the usage of a simplified exchange coupling scheme and relying on DFT based magneto-structural correlation we have been able to explain the observed diamagnetic ground state. Concerning compound 2, DC magnetic data supported by X-band EPR measurements suggest the existence of anisotropy with a zero-field splitting parameter D, at least in the range of 2?10 cm&#8722;1. In agreement with this description, a slow relaxation of magnetization is observed after applying a small external magnetic field, under AC measurements. Field and temperature dependence of the characteristic relaxation time establishes a thermal barrier for magnetization reversal of about 25 cm&#8722;1  , which is in good agreement with the energy splitting of the |±1\/2&#9002; and |±3\/2&#9002; doublets established from static magnetic measurements.","palabras_clave":"no corresponde"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":989,"idioma_id":4,"titulo":"First report of helminth parasitizing Trachycephalus typhonius (Anura: Hylidae) from northeastern, Argentina","resumen":"Two species of nematodes, Rhabdias cf. elegans (Rhabdiasidae) and Aplectana hylambatis (Cosmocercidae), were recovered from the lungs and intestine of Trachycephalus typhonius (Anura: Hylidae) captured in Formosa Province, Argentina. Morphological and morphometric data of both species are provided, and previous records of Rhabdias spp. in the Neotropical region are summarized. The finding of Rhabdias cf. elegans constitutes the first record of this genus in the Formosa Province, and the finding of A. hylambatis represents the first record of this species as a parasite of hylid frogs, and the first report in Formosa Province. Trachycephalus typhonius represents a new host for both parasites.","palabras_clave":"Rhabdias cf. elegans|Aplectana hylambatis|Veined tree frog|Formosa Province"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":990,"idioma_id":4,"titulo":"Chromosomal differentiation of Tribe Cestreae (Solanaceae) by analyses of 18-5.8-26S and 5S rDNA distribution","resumen":"Tribe Cestreae is monophyletic with three genera: Cestrum, Sessea, and Vestia. Karyotypically, it is outstanding within Solanaceae by several features: (1) basic number x = 8, (2) large chromosome sizes, (3) complex heterochromatin patterns, (4) occurrence of B-chromosomes (Bs) in Cestrum with particular banding patterns and rDNA sites distribution, and (5) absence of Arabidopsis-type telomeres. Seventeen South American Cestreae species from the three genera were studied using fluorescence in situ hybridization (FISH) with ribosomal DNA regions (5S and 18-5.8-26S) as probes, with the aim of recognizing specific or group-specific chromosomal markers and analyzing karyotype diversity in a systematic and evolutionary context. The first chromosome number report for Cestrum euanthes, C. kunthii, C. lorentzianum, and C. tomentosum is included. Variation in number and distribution of rDNA loci was observed among the species, concerning both As and Bs chromosomes. Despite the constancy of the karyotype and numbers of rDNA loci, the mapping of 18-5.8-26S and 5S rDNA loci allowed to differentiate Cestreae genera and species groups within Cestrum, highlighting the importance of these markers as cytotaxonomic character in this tribe.","palabras_clave":"B-chromosomes|Cestrum|chromosome numbers|karyotype evolution|ribosomal DNA|Sessea|Vestia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":991,"idioma_id":5,"titulo":"Cefalea Neuralgiforme Unilateral de Breve Duración con Inyección Conjuntival y Lagrimeo (SUNCT) y respuesta al levetiracetam","resumen":"Las cefaleas autonómico trigeminales (CAT) son cefaleas primarias de presentación infrecuente y comparten varios rasgos comunes, como síntomas autonómicos y pobre respuesta terapéutica. Dentro de este grupo, el SUNCT no ha mostrado respuesta a una medicación específica. La mayoría de los tratamientos son por reportes de casos. La lamotrigina, la gabapentina y la lidocaína parenteral como abortivo son las estrategias de primera elección. Reportamos el caso de un paciente que respondió favorablemente al levetiracetam, abriendo otra oportunidad terapéutica.","palabras_clave":"SUNCT|Levetiracetam|Tratamiento"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":992,"idioma_id":5,"titulo":"Efectos de la tracción mecánica sobre el soporte textil de una antigua obra pictórica de gran formato.","resumen":"La intervención sobre antiguas obras de gran formato involucra, entre otras operaciones, el estudio mecánico del soporte textil. El objeto del trabajo es evaluar la resistencia mecánica de la tela pintada que oficia de telón de boca en el teatro ?El Círculo? de la ciudad de Rosario en la Provincia de  Santa Fe, Argentina. Se presenta una moderna metodología experimental que facilitó el estudio de la repuesta mecánica de las fibras de tela sometidas a una tracción uniaxial a velocidad de deformación constante. El efecto de la tracción sobre las diferentes probetas de tela se determina por un lado, a través del esfuerzo mecánico que soporta la trama y por otro, a través de la observación de los cambios en la estructura del  tejido mediante microscopía óptica. Se presentan los resultados obtenidos mediante la utilización de esta técnica y se sugieren futuros cursos de investigación.","palabras_clave":"traccion mecanica|conservacion|gran formato|textiles antiguos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":993,"idioma_id":6,"titulo":"Politiques et poétiques de la mémoire dans le documentaire argentin contemporain","resumen":"Estudio sobre las transformaciones en la reciente producción documental argentina, en relación a uss estrategias discursivas y las políticas de la memoria implicadas.","palabras_clave":"Cine|Documental|Historia|Memoria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":995,"idioma_id":4,"titulo":"Influence of z\/w relation in Chill Block Melt Spinning  (CBMS) process and analysis of thickness in ribbons","resumen":"The aim of this work is to show that z\/w relationship considered by Wang (2010) , is also obtained with our data  set, and we  can also approximate  that data with an decreasing exponential function at the same speed range of rotating wheel (Vx). Similar decay adjustment for  the  thickness  (t) of  the ribbon  is proposed  for  the  reported data by other authors. Both types of decay which are proposed, are due  to decreasing  the exponential  type with Vx, and can be attributed  to Newtonian  cooling  in  the molten metal  into a  convective  fluid medium such as atmospheric air. This z\/w relationship allows to pose simplified 2D models with lower computational times associated.","palabras_clave":"THIN FILMS|SOLIDIFICATIONS|PARAMETERS|MAGNETIC MATERIALS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":997,"idioma_id":4,"titulo":"Effect of thickness on structural and electrical properties of Al-doped ZnO films","resumen":"In this work, we have investigated the influence of thickness on structural and electrical properties of Al-doped ZnO films. Transparent conducting oxide films were grown by the spray pyrolysis technique from precursors prepared via the sol?gel method. We determined the structural properties of the films by performing X-ray diffraction and mosaicity measurements, which evidenced an increase of disorder and inhomogeneity between crystalline domains as the films thickened. This behavior was contrasted with results obtained from electrical measurements and was attributed to plastic deformation of the films as their thickness increased. As a result, the carrier mobility, the optical gap and the activation energy are affected due to emerging grain boundaries and a higher degree of disorder.","palabras_clave":"Cinc Oxide|X-Ray"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":998,"idioma_id":5,"titulo":"Diagenesis y Procedencia de la Formación Los Colorados (Noriano), Cuenca de Ischigualasto-Villa Unión, Noroeste de Argentina","resumen":"En este trabajo se discuten la historia diagenética y las áreas de proveniencia de La Formación Los Colorados, unidad de bancos rojos que representa el relleno final de la cuenca triásica de Ischigualasto-Villa Unión. Esta Formación fue muestreada en su área tipo y las investigaciones corresponden al análisis de 45 secciones delgadas, estudios por microscopía electrónica de barrido y ocho análisis químicos de areniscas. Desde el punto de vista diagenético fueron consideradas dos situaciones diferentes, ya que el medio depositacional influyó fuertemente en la ulterior diagénesis: 1. areniscas tempranamente cementadas por yeso, probablemente vinculadas a pequeños cuerpos de agua efímeros, y 2. areniscas con mucho más complejos patrones diagenéticos, posiblemente  relacionadas a ambientes fluviales no inundados. En este último caso se reconocieron cuatro estados diagenéticos que se desarrollaron entre la eogénesis y la mesogénesis temprana,predominando ampliamente la compactación física sobre la química. Las areniscas muestran valores máximos de porosidad ligeramente superiores al 10%, corresponden a porosidad secundaria, principalmente intergranular. Teniendo en cuenta la morfología, conectividad, tamaño y tipo de porel se identificaron tres patrones porales dominantes. En lo que respecta a  las áreas de proveniencia, las modas detríticas y los análisis químicos de areniscas indican que el aporte fue tanto desde el basamento metamórfico-ígneo de la Sierra de Valle Fértil, como de las rocas graníticas de las Sierras de Sañogasta. Además, se descarta a la Precordillera como área de proveniencia durante la depositación de la Formación Los Colorados en esta área.","palabras_clave":"Procedencia|Diagénesis|Triásico|Cuenca Ischigualasto"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":999,"idioma_id":4,"titulo":"A revision of the fishtail effect in YBa_2Cu_3O_(7-d) crystals and its connection with vortex dynamics","resumen":"The fishtail magnetization observed in many type II superconductors has been investigated since the earliest nineties and associated with different phase transitions and dynamic crossovers in complex vortex matter. In systems without a sharp order?disorder phase transition, the fishtail has been related with a crossover from elastic to plastic vortex creep regimes. In this paper we perform a critical revision of this accepted picture. We show that, in slightly underdoped YBa_2Cu_3O_(7-delta) single crystals, there is a clear correlation between the fishtail magnetization and the Peak Effect observed in ac experiments with the associated history effects. We propose that both features are originated in the same dynamic crossover, between two plastic creep regimes. The proposed picture can also apply to other system, as those belonging to same families of iron-based pnictides.","palabras_clave":"YBCO|SUPERCONDUCTIVIDAD|VORTICES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1009,"idioma_id":4,"titulo":"Myocardial Mineralocorticoid Receptor Activation by Stretching and Its Functional Consequences","resumen":"Myocardial stretch triggers an angiotensin II?dependent autocrine\/paracrine loop of intracellular signals,leading to reactive oxygen species?mediated activation of redox-sensitive kinases. Based on pharmacological strategies,we previously proposed that mineralocorticoid receptor (MR) is necessary for this stretch-triggered mechanism.Now, we aimed to test the role of MR after stretch by using a molecular approach to avoid secondary effects ofpharmacological MR blockers. Small hairpin interference RNA capable of specifically knocking down the MR wasincorporated into a lentiviral vector (l-shMR) and injected into the left ventricular wall of Wistar rats. The samevector but expressing a nonsilencing sequence (scramble) was used as control. Lentivirus propagation through the leftventricle was evidenced by confocal microscopy. Myocardial MR expression, stretch-triggered activation of redoxsensitivekinases (ERK1\/2-p90RSK), the consequent Na+\/H+ exchanger?mediated changes in pHi (HEPES-buffer), andits mechanical counterpart, the slow force response, were evaluated. Furthermore, reactive oxygen species productionin response to a low concentration of angiotensin II (1.0 nmol\/L) or an equipotent concentration of epidermal growthfactor (0.1 &#956;g\/mL) was compared in myocardial tissue slices from both groups. Compared with scramble, animalstransduced with l-shMR showed (1) reduced cardiac MR expression, (2) cancellation of angiotensin II?induced reactiveoxygen species production but preservation of epidermal growth factor?induced reactive oxygen species production,(3) cancellation of stretch-triggered increase in ERK1\/2-p90RSK phosphorylation, (4) lack of stretch-induced Na+\/H+exchanger activation, and (5) abolishment of the slow force response. Our results provide strong evidence that MRactivation occurs after myocardial stretch and is a key factor to promote redox-sensitive kinase activation and theirdownstream consequences.","palabras_clave":"Na+\/H+ exchanger  | mineralocorticoid receptors|myocardial stretch"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1014,"idioma_id":4,"titulo":"Insecticidal activity of volcanic ash on Sitophilus oryzae L. (Coleoptera: Curculionidae) under laboratory conditions","resumen":"ABSTRACT. This study assessed the acute toxicity and repellence as well as feeding deterrence effect of volcanic ash (VA) on Sitophilus oryzae adults under laboratory conditions. VA resulted in significant adult mortality of S. oryzae. Acute toxicity of the VA was similar to that of commercially available diatomaceous earth DiatomiD® demonstrating its insecticidal potential. Median lethal concentration values (LC50) obtained were 1610 [1449, 1778] mg\/kg for VA and 1046 [916, 1168] mg\/kg for DiatomiD®.Similarly to other inert dusts, VA particle size shows a bi-modal distribution and porosity which increases its surface area. Among the smallest particles, the highest volumetric loading was close to 5 µm with a distribution of smaller particles peaking at 0.5µm. Results indicate that VA is not repellent to S. oryzae. An ?engagement? response or increased interaction of the insects with the VA treated surface was observed. However, feeding deterrence indices showed that both VA and diatomaceous earth had strong feeding deterrent action. Contact of insects with VA may lead to mortality by adherence of the VA particles to the insect cuticle. However, insects prefer feeding on sites without VA covered substrates and this could have a positive impact on its use for pest management.","palabras_clave":"VOLCANIC ASH|INSECTICIDE ACTIVITY|TOXICITY TEST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1015,"idioma_id":4,"titulo":"Development of lentiviral vectors for transient and stable protein overexpression in mammalian cells. A new strategy for recombinant human FVIII (rhFVIII) production","resumen":"Recombinant protein overexpression in mammalian cells constitutes a real challenge in therapeutic protein production. Following the discovery of intron functionality in gene expression, various expression vectors that include them in their sequences have been developed. In this study, the main goal was to develop new lentiviral vectors (LVs) carrying different promoter and intron-containing 5´LUTR (5´ untranslated region) combinations and the design of LVs for rhFVIII production in Chinese hamster ovary (CHO) cells. RESULTS: By combining the human cytomegalovirus (CMV) or the elongation factor 1a (EF-1a) promoters along with different 5´UTRs that included leader introns, between 2 and 12-fold increases were reached, when transient and stable expression of the enhanced green fluorescent protein (EGFP) and rhFVIII were analyzed. Also, new LVs provided with promoters and 5´UTRs from high expression genes, according to a gene database, were designed. Three of them were shown to be superior to the EF-1a promoter in three widely used cell lines. CONCLUSION: In the present work, LVs containing different promoters and 5´UTRs were designed. In transient and stable assays some of these constructs have shown higher activity compared with commercial promoters and, therefore, constitute promising candidates for therapeutic protein production.","palabras_clave":"LENTIVIRAL VECTOR|RHFVIII PRODUCTION|PROTEIN OVEREXPRESSION|CMV ENHANCER\/PROMOTER|EF-1ALPHA PROMOTER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1017,"idioma_id":4,"titulo":"Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis","resumen":"SCOPE:         Quercetin is the most abundant flavonoid in human   diet. It has special interest as it holds anticancerous properties. This   study aims to clarify the mechanisms involved in quercetin effects   during the occurrence of preneoplastic lesions in rat liver.        METHODS AND RESULTS:         Adult   male Wistar rats were subjected to a two-phase model of   hepatocarcinogenesis (initiated-promoted group). Initiated-promoted   animals also received quercetin 10 and 20 mg\/kg body weight (IPQ10 and   IPQ20 groups, respectively). Antioxidant defenses were modified by   quercetin administration at both doses. However, only IPQ20 group showed   a reduction in number and volume of preneoplastic lesions. This group   showed increased apoptosis and a reduction in the proliferative index.   In addition, IPQ20 group displayed a reduction of cell percentages in G&#8321;   and S phases, accumulation in G&#8322;, and decrease in M phase, with reduced   expression of cyclin D1, cyclin A, cyclin B, and cyclin-dependent   kinase 1. Interestingly, peroxisome proliferator activated receptor-&#945;   levels were reduced in IPQ20 group.        CONCLUSION:         The   outcomes of this study represent a significant contribution to the   current understanding on the preventive mechanisms of quercetin during   the early stages of liver cancer development, demonstrating that in   addition to its known proapoptotic characteristics, the flavonoid   modulates the expression of critical cell cycle regulators and   peroxisome proliferator activated receptor-&#945; activity.","palabras_clave":"APOPTOSIS|PRENEOPLASTIC LIVER|PROLIFERATION|QUERCETIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1023,"idioma_id":4,"titulo":"Effects Of A Metabolic Syndrome Induced By A Fructose-Rich Diet On Bone Metabolism In Rats","resumen":"Objective. The aims of this study were: first, to evaluate the possible effects of afructose rich diet (FRD)-induced metabolic syndrome (MS) on different aspects of longbone histomorphometry in young male rats; second, to investigate the effects of thisdiet on bone tissue regeneration; and third, to correlate these morphometric alterationswith changes in the osteogenic\/adipogenic potential and expression of specifictranscription factors, of marrow stromal cells (MSC) isolated from rats with fructoseinducedMS.Materials\/Methods. MS was induced in rats by treatment with a FRD for 28 days. Halfwaythrough treatment, a parietal wound was made and bone healing was evaluated 14 dayslater. After treatments, histomorphometric analysis was performed in dissected femoraland parietal bones. MSC were isolated from the femora of control or fructose-treated ratsand differentiated either to osteoblasts (evaluated by type 1 collagen, Alkaline phosphataseand extracellular nodule mineralization) or to adipocytes (evaluated by intracellulartriglyceride accumulation). Expression of Runx2 and PPAR&#947; was assessed by Western blot.Results. Fructose-induced MS induced deleterious effects on femoral metaphysismicroarchitecture and impaired bone regeneration. Fructose treatment decreased theosteogenic potential of MSC and Runx2 expression. In addition, it increased the adipogeniccommitment of MSC and PPAR&#947; expression.Conclusions. Fructose-induced MS is associated with deleterious effects on bonemicroarchitecture and with a decrease in bone repair. These alterations could be due to adeviation in the adipogenic\/osteogenic commitment of MSC, probably by modulation of theRunx2\/PPAR&#947; ratio","palabras_clave":"Fructosa|Sindrome Metabolico|regeneracion osea"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1026,"idioma_id":4,"titulo":"Long  range periodicity of S\/Au(111) structures at low and intermediate coverages","resumen":"Through a systematic analysis based on DFT calculations, we have studied   the adsorption of S atoms on Au(111) at low and intermediate coverages   (&#952; &#8804; 1\/3). Our calculations predict ground state structures   characterized by two periodicities: (5 × 5) and (&#8730;3 × &#8730;3)R30°. In line with experiments, the (5 × 5) periodicity seems to dominate in a much larger coverage range than the (&#8730;3 × &#8730;3)R30°   one, which should be only observable in a narrow coverage window close   to 1\/3. In addition, our results unambiguously reveal the crucial role   of S-induced substrate relaxation. Using a first-principles parametrized   lattice-gas Hamiltonian approach, we determine lateral interactions   between S atoms which allow us to provide a sound explanation for the   relative stability of ground state structures.","palabras_clave":"azufre|Au(111)|fases"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1029,"idioma_id":4,"titulo":"Effect of gamma irradiation and storage time on microbial growth and physicochemical characteristics of pumpkin (Cucurbita Moschata Duchesne ex Poiret) puree","resumen":"  The effect of gamma irradiation (0?2 kGy) and storage time (0?28 days) on microbial growth and physicochemical characteristics of a packed pumpkin puree was studied. For that purpose, a factorial design was applied. The puree contained potassium sorbate, glucose and vanillin was stored at 25 C. Gamma irradiation diminished and storage time increased microbial growth. A synergistic effect between both variables on microbial growth was observed. Storage time decreased pH and color of purees. Sorbate content decreased with storage time and gamma irradiation. Mathematical models of microbial growth generated by the factorial design allowed estimating that a puree absorbing 1.63 kGy would have a shelf-life of 4 days. In order to improve this time, some changes in the applied hurdles were assayed. These included a thermal treatment before irradiation, a reduction of irradiation dose to 0.75 kGy and a decrease in storage temperature at 20 C. As a result, the shelf-life of purees increased to 28 days.","palabras_clave":"Gamma irradiation|pumpjin|microbial spoilage|color stability"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1030,"idioma_id":4,"titulo":"Identification of phospholipase activity in Rhinella arenarum sperm extract capable of inducing oocyte activation","resumen":"Egg activation, which includes cortical granule exocytosis, resumption and completion of meiosis and pronuclear formation culminates in the first mitotic cleavage. However, the mechanism through which the fertilizing sperm induces this phenomenon is still controversial. We investigated the effect of the microinjection of homologous sperm soluble fractions obtained by fast protein liquid chromatography (FPLC) from reacted sperm (without acrosome) and non-reacted sperm on the activation of Rhinella arenarum oocytes matured in vitro. The FPLC-purified sperm fraction obtained from reacted or non-reacted sperm is able to induce oocyte activation when it is microinjected. This fraction has a 24 kDa protein and showed phospholipase C (PLC) activity in vitro, which was inhibited by D-609 but not by n-butanol or neomycin, suggesting that it is a PLC that is specific for phosphatidylcholine (PC-PLC). The assays conducted using inhibitors of inositol triphosphate (IP3) and ryanodine receptors (RyRs) indicate that the fraction with biological activity would act mainly through the cADPr (cyclic ADP ribose) pathway. Moreover, protein kinase C (PKC) inhibition blocks the activation produced by the same fraction. Immunocytochemical studies indicate that this PC-PLC can be found throughout the sperm head.","palabras_clave":"PHOSPHOLIPASE|SPERM|AMPHIBIAN|OOCYTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1034,"idioma_id":4,"titulo":"IFABP portal region insertion during membrane interaction depends on phospholipid composition","resumen":"Intestinal fatty acid-binding protein (IFABP) is highly expressed in the intestinal epithelium and it belongs to the family of soluble lipid binding proteins. These proteins are thought to participate in most aspects of the biology of lipids, regulating its availability for specific metabolic pathways, targeting and vectorial trafficking of lipids to specific subcellular compartments. The present study is based on the ability of IFABP to interact with phospholipid membranes, and we characterized its immersion into the bilayer´s hydrophobic central region occupied by the acyl-chains. We constructed a series of Trp-mutants of IFABP to selectively probe the interaction of different regions of the protein, particularly the elements forming the portal domain that is proposed to regulate the exit and entry of ligands to\/from the binding cavity. We employed several fluorescent techniques based on selective quenching induced by soluble or membrane confined agents. The results indicate that the portal region of IFABP penetrates deeply into the phospholipid bilayer, especially when CL-containing vesicles are employed. The orientation of the protein and the degree of penetration were highly dependent on the lipid composition, the superficial net charge and the ionic strength of the medium. These results may be relevant to understand the mechanism of ligand transfer and the specificity responsible for the unique functions of each member of the FABP family.","palabras_clave":"Fatty acid binding protein|Proteinlipid interaction| Intracellular lipid traffic| Intestinal lipid traffic|Brominated phospholipid"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1047,"idioma_id":4,"titulo":"Alluvial fan deposition along a rift depocentre border from the Neuquén Basin, Argentina","resumen":"The interaction between hangingwall block rotation and alluvial deposition is examined from Late Triassic?Early Jurassic successions exposed along the Catán Lil half-graben border fault system in the Neuquén Basin, Argentina. Analysis of transport and depositional processes, clast composition and rock body geometry allowed the identification of three distinctive fan-shaped alluvial units. The contrasting lithologic nature of the basement (igneousmetamorphic)and syn-rift fill (volcanic and volcanic-derived) permits detailed studies of clast provenance. The origin of each alluvial system (footwall- vs. hangingwall-derived) can thus be verified. A simple method was implemented to establish the geometry of each alluvial unit by comparing the stereographic projection of its bedding to that of an idealised fan shaped body. Results show that the three alluvial systems occupied the same relative location in the rift depocentre. Unit 1 is interpreted as an alluvial fan orientated transverse to the depocentre border fault system and fed from the footwall. Non-cohesive debris flow deposition was the dominant process in this environment. Unit 2 is interpreted as a mainly hangingwall-fed alluvial fan, parallel to the depocentre border fault system and shows an upward decrease in footwall-derived clasts. Hyperconcentrated flow was the principal transport process. Unit 3 represents a fan delta, parallel to the depocentre border fault system. Its components are completely hangingwall-derived and hyperconcentrated flow deposition was the dominant process. Differences in grain-size, composition, transport directions and fan body geometry are proved to be directly linked to variations in ground tilting induced by the direction of hangingwall block rotation in an endorheic rift depocentre.","palabras_clave":"Alluvial processes| Structural controls| Alluvial fan orientation|Syn-rift|Neuquén Basin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1049,"idioma_id":4,"titulo":"Molecular diagnosis of dystrophinopathies using a multi-technique analysis algorithm","resumen":"Introduction: Dystrophinopathies are X-linked recessive neuromuscular diseases caused by mutations in the dystrophin gene. In this study we aimed to detect mutations within the dystrophin gene in DMD patients, to determine the carrier status of women, and to perform a prenatal diagnosis. Methods: We analyzed 17 individuals from 2 unrelated families with a history of DMD. We used multiplex PCR, multiplex ligation-dependent probe amplification (MLPA), and short tandem-repeat (STR) segregation analysis to accurately detect and characterize the mutations and to identify the at-risk haplotype. Results: The selected methodology allowed for characterization of 2 single-exon out-of-frame deletions in affected patients. Nine of 13 women and a fetus were excluded from being carriers. Three recombination events were found and suggested that germline mosaicism had occurred in both families. Conclusions: This methodology proved to be efficient for characterizing the disease-causing mutation in affected individuals and for assessing the carrier status in healthy relatives. These findings helped inform precise genetic counseling and contributed to characterization of the disease in the Argentine population. © 2013 Wiley Periodicals, Inc.","palabras_clave":"CARRIER DETECTION|DMD|DUCHENNE|DYSTROPHIN GENE|MOLECULAR DIAGNOSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1053,"idioma_id":4,"titulo":"LOGOS: Enabling Local Resource Managers for the Efficient Support of Data-intensive Workflows Within Grid Sites","resumen":"In this study we discuss how to enable grid sites for the support of data-intensive workflows. Usually, within grid sites, tasks and resources are administrated by local resource managers (LRMs). Many of LRMs have been designed for managing compute-intensive applications. Therefore, data-intensive workflow applications might not perform well on such environments due to the number and size of data transfers between tasks. To improve the performance of such kind of applications it is necessary to redefine the scheduling policies integrated on LRMs. This paper proposes a novel scheme for efficiently supporting data-intensive workflows in LRMs within grid sites. Such scheme is partially implemented in our grid middleware LOGOS and used to improve the performance of a well known LRM: HTCondor. The core of LOGOS is a novel communication-aware scheduling algorithm (PPSA) capable of finding near-optimal solutions. Experiments conducted in this study showed that our approach leads to performance improvements up to 52% in the management of data-intensive workflow applications.","palabras_clave":"Grid sites|data-intensive workflows|scheduling|HTCondor DAGMan"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1054,"idioma_id":4,"titulo":"An approach for supporting distributed user interface orchestration over the Web","resumen":"Currently, a lot of the tasks engaged by users over the Web involve dealing with multiple Web sites. Moreover, whilst Web navigation was considered as a lonely activity in the past, a large proportion of users are nowadays engaged in collaborative activities over the Web. In this paper we argue that these two aspects of collaboration and tasks spanning over multiple Web sites call for a level of coordination that require Distributed User Interfaces (DUI). In this context, DUIs would play a major role by helping multiple users to coordinate their activities whilst working collaboratively to complete tasks at different Web sites. For that, we propose in this paper an approach to create distributed user interfaces featuring procedures that are aimed to orchestrate user tasks over multiple Web sites. Our approach supports flexible process modeling by allowing users to combine manual tasks and automated tasks from a repertoire of patterns of tasks performed over the Web. In our approach, whilst manual tasks can be regarded as simple instructions that tell users how to perform a task over a Web site, automated tasks correspond to tools built under the concept of Web augmentation (as it augments the repertoire of tasks users can perform over the Web) called Web augmenters. Both manual and automated tasks are usually supported by specific DOM elements available in different Web sites. Thus, by combining tasks and DOM elements distributed in diverse Web sites our approach supports the creation of procedures that allows seamless users interaction with diverse Web site. Moreover, such an approach is aimed at supporting the collaboration between users sharing procedures. The approach is duly illustrated by a case study describing a collaborative trip planning over the Web.","palabras_clave":"Distributed User Interfaces|Task and process modeling|Web application|Web augmenation|Collaborative Web tasks"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1060,"idioma_id":4,"titulo":"Evaluation of volatile compounds produced by Lactobacillus paracasei I90 in a hard-cooked cheese model using solid phase microextraction","resumen":"Selected strains of mesophilic lactobacilli with key enzymatic activities may be employed to intensify or diversify cheese flavor during ripening. Among enzymes of interest, aminotransferases are most important, as they are involved in the first step of amino acid (AA) catabolism. In previous studies, Lactobacillus paracasei I90 has been shown to increase both the secondary proteolysis in soft and semi-hard cheeses and the production of volatile compounds in mini-soft cheeses. In this work, its potential for the formation of volatile compounds derived from AA catabolism was assessed by solid phase microextraction coupled to GC-FID\/MS in a hard-cooked cheese model, consisting of a cheese extract sterilized by filtration. Lb. paracasei I90 showed aminotransferase activity towards all the AAs studied (branched-chain AAs, aromatic AAs, aspartic acid and methionine). The highest levels were observed for aspartic (Asp), followed by branched-chain AAs and tryptophane (Trp). Among the volatile compounds derived from AAs, 2-methylbutanal, 3-methylbutanal, diacetyl, 3-methyl1-butanol, acetic and 3-methylbutanoic acids were detected at higher level in extracts inoculated with Lb. paracasei I90 than in controls. It was concluded that the production of volatile compounds by Lb. paracasei I90 in a hard cheese model was consistent with its main aminotransferase activities, making this strain a good candidate for enhancing flavour in hard cheeses.","palabras_clave":"AMINO ACID CATABOLISM|LACTOBACILLUS PARACASEI |CHEESE MODEL|VOLATILE COMPOUNDS|SPME-GC-FID\/MS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1061,"idioma_id":4,"titulo":"Strong phenological differences between two populations of a Neotropical funnel-web wolf spider","resumen":"Comparisons of phenological patterns among populations within a species are uncommon in arachnids. Aglaoctenus lagotis is a wolf spider that lives in funnelwebs across South America. The aim of this study was to describe the phenological patterns of two distant populations of A. lagotis (central Argentina, CA, and southern Uruguay, SU). Individuals of each population were sighted along transects, every month for two years. The CA and SU populations differed in their phenological patterns (Wald &#967;2 = 966.94, df = 66; p <0.001). The CA population showed a spring?summer unified reproductive season and immature individuals overwintered. SU showed the sexual period during autumn, the maternal period during spring?summer and the females, mostly mated, overwintered. These strong  differences imply temporal isolation in mating possibilities between both populations. The differences encountered could be due to phenotypic plasticity or have a phylogenetic basis. Interpopulation studies of other features of A. lagotis would show whether they also vary, suggesting speciation.","palabras_clave":"phenology|populations|sedentary lycosid|Aglaoctenus lagotis|Neotropics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1074,"idioma_id":4,"titulo":"Effect of Forward\/Inverse Model Asymmetries Over Retrieved Soil Moisture Assessed With an OSSE for the Aquarius\/SAC-D Mission","resumen":"An Observing System Simulation Experiment (OSSE) for the Aquarius\/SAC-D mission has been developed for assessing the accuracy of soil moisture retrievals from passive L-band remote sensing. The implementation of the OSSE is based on the following: a 1-km land surface model over the Red-Arkansas River Basin, a forward microwave emission model to simulate the radiometer observations, a realistic orbital and sensor model to resample the measurements mimicking Aquarius operation, and an inverse soil moisture retrieval model. The simulation implements a zero-order radiative transfer model. Retrieval is performed by direct inversion of the forward model. The Aquarius OSSE attempts to capture the influence of various error sources, such as land surface heterogeneity, instrument noise, and retrieval ancillary parameter uncertainty, all on the accuracy of Aquarius surface soil moisture retrievals. In order to assess the impact of these error sources on the estimated volumetric soil moisture, a quantitative error analysis is performed by comparison of footprint-scale synthetic soil moisture with ?true? soil moisture fields obtained from the direct aggregation of the original 1-km soil moisture field input to the forward model. Results show that, in heavily vegetated areas, soil moisture retrievals have a positive bias that can be suppressed with an alternative aggregation strategy for ancillary parameter vegetation water content (VWC). Retrieval accuracy was also evaluated when adding errors to 1-km VWC (which are intended to account for errors in VWC derived from remote sensing data). For soil moisture retrieval root-mean-square error on the order of 0.05 $hbox{m}^{3}\/hbox{m}^{3}$, the error in VWC should be less than 12%.","palabras_clave":"land cover|moisture|remote sensing|soli|vegetation|Aquarius mission|Observing System Simulation Experiment|SAC-D mission|canopy structure|canopy vegetation scattering|complex scattering properties|dense vegetated areas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1083,"idioma_id":4,"titulo":"Maternal isolation during the first two postnatal weeks affects novelty-induced responses and sensitivity to ethanol-induced locomotor activity during infancy","resumen":"Abstract  Animals exposed to chronic maternal separation exhibit enhanced ethanol self-administration and greater hormonal and behavioral responsiveness to stress in adulthood. Whether the effects of maternal separation are immediately evident in infancy or whether they appear only later on development is still an unanswered question This study tested sensitivity to ethanol?s behavioral stimulating effects in infant rats that experienced maternal separation (MS) from postnatal day 1 to 14. MS infants exhibited significantly greater reactivity to the motor stimulating effects of 1.25 g\/kg ethanol than control animals, yet greater motor suppression after 2.5 g\/kg ethanol. Baseline level of response to novelty was altered in MS infants, in a nor-binaltorphimine insensitive manner, i.e., despite modified activity of the kappa-opioid","palabras_clave":"MATERNAL ISOLATION|RAT|ETHANOL|PREWEANLING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1084,"idioma_id":4,"titulo":"Batrachochytrium dendrobatidis infecting anurans in a protected area from Santa Fe province, Argentina","resumen":"The emerging infectious diseases have been proposed as  responsible of global decline of amphibians? worldwide. The chytrid fungus Batrachochytrium dendrobatidis -Bd- (Fungi: Chytridiomycetes: Rhyzophydiales) has been  highlighted as suspected driver of global amphibian declines, even in protected.  In this work we collect DNA samples for looking Bd infection through molecular techniques in 28 adult anurans (5 Dendropsophus nanus, 10 Hypsibioas pulchellus, 1 Leptodactylus latrans, 10 Rhinella fernandezae, 1 R. schneideri and 1 Scinax nasicus) captured in Campo Rico island, the biggest island  of Parque Nacional Islas de Santa Fe (PNISF) during winter of 2009. Two out of ten H.  pulchellus resulted positive for Bd  analysis. None of the other individuals were found infected. None of the specimens  showed clinical signs of chytridiomycosis when collected; neither infected nor  no infected ones. No unusual sloughing of the skin, no slimness and no  mortality were observed. Given the seasonal peaks of anuran assemblage activity  in studied environments, it is necessary to carry out spring-summer samplings  to analyze a greater number of taxa and specimens, thus assessing the spread of  infection in PNISF amphibians. In addition, it is important to establish a  long-term monitoring plan to evaluate whether Bd presence affects the dynamics of infected populations. Finally,  it is essential to alert environmental authorities on the findings and issue  administrators, park rangers and citizens about amphibians? conservation  concern in Paraná River wetlands.","palabras_clave":"Batrachochytrium dendrobatidis|Anurans|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1090,"idioma_id":4,"titulo":"A taxonomic review of the goblin spiders of the genus Dysderoides Fage and their himalayan relatives of the genera Trilacuna Tong & Li, and Himalayana new genus (Araneae: Oonopidae)","resumen":"The study of many museum  specimens of goblin spiders from the Himalayan range and neighboring countries  allows the description of new taxa of the family Oonopidae. The genus Dysderoides Fage is taxonomically  reviewed. It comprises small, blind, loricate troglobitic spiders: the type  species (D. typhlos Fage, from India) and, at least, five new species from Northern  India (D. synrang Grismado &amp;  Deeleman) and Thailand  (D. muang Grismado &amp; Deeleman, D. kaew Grismado &amp; Deeleman, D. kanoi Grismado &amp; Deeleman, and D. lawa Grismado &amp; Deeleman). The  genus Trilacuna,&nbsp; previously known from China, Thailand,  Sumatra and Malaysia, is newly diagnosed by the loss of the furrow connecting  the posterior spiracles in males, and is represented in the Himalayan region by  seven species: T. aenobarbus  (Brignoli), from Bhutan (here transferred from Epectris Simon), and six new: four from Northern India (T. meghalaya Grismado &amp; Piacentini,T. besucheti Grismado &amp; Piacentini, T.  mahanadi Grismado &amp;  Piacentini, and T. loebli Grismado  &amp; Piacentini), one from India and Nepal (T. bangla Grismado &amp; Ramírez), and one from Pakistan (T. hazara Grismado &amp; Ramírez). The  new genus Himalayana Grismado comprises  species very similar to those of Trilacuna,  but differing by characteres of the postepigastric scuta and by having an  additional acute dorso-prolateral projection on the male palpi. Six new species  are assigned to Himalayana: H. kathmandu  Grismado (type species), H. castanopsis  Grismado, H. parbat Grismado, H. martensi Grismado (all from Nepal), H. siliwalae Grismado and H. andreae Grismado (from India). The  study of the internal female genitalia of T.  meghalaya and T. bangla revealed  a complex copulatory system, and an entelegyne condition, apparently uniform  for the entire genus and probably for Dysderoides  and Himalayana as well. The males of  the three genera have a complex set of paraembolic laminae and a brush of filiform  structures where discharges a gland, through a thin, tortuous cuticular tube. The  genitalic and somatic morphology of the three genera suggest that they conform  a monophyletic group, here named ?Dysderoides  complex?, and that their closer relatives can be found among Prethopalpus Baehr et al., and other  genera related to Silhouettella  Benoit. The loss of the membranous diagonal area on the base of the anterior  lateral spinnerets is proposed as a synapomorphy of an advanced group of  loricatae oonopids usually referred as gamasomorphines. Furthermore Triaeris glenniei Fage, described from a  single female from a cave in Uttarakhand, is redescribed and transferred to Camptoscaphiella Caporiacco.","palabras_clave":"Oonopidae|Taxonomy|Himalaya|Spiders"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1092,"idioma_id":4,"titulo":"Effects of sewage discharges on lipid and fatty acid composition of the Patagonian bivalve Diplodon chilensis","resumen":"Lipid and fatty acid (FA) composition and selected oxidative stress parameters of  freshwater clams (Dipolodon chilensis), from a sewage-polluted (SMA) and a clean site,  were compared. Trophic markers FA were analyzed in clams and sediment. Saturated  FA (SAFA), and bacteria and sewage markers were abundant in SMA sediments, while  diatom markers were 50% lower. Proportions of SAFA, branched FA, 20:5n-3 (EPA)  and 22:6n-3 (DHA) were higher in SMA clams. Chronic exposure of D. chilensis to  increasing eutrophication affected its lipid and FA composition. The increase in EPA  and DHA proportions could be an adaptive response, which increases stress resistance  but could also lead to higher susceptibility to lipid peroxidation TBARS, lipofuscins  (20-fold) and GSH concentrations were higher in SMA clams. FA markers indicated  terrestrial plant detritus and bacteria are important items in D. chilensis diet.  Anthropogenic input in their food could be traced using specific FA as trophic markers","palabras_clave":"FRESHWATER BIVALVE|POLLUTION|DOMESTIC EFFLUENTS|OXIDATIVE STRESS|LIPOFUSCINS|FATTY ACID MARKERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1098,"idioma_id":4,"titulo":"Non-linear oscillations of a thin-walled composite beam with shear deformation","resumen":"A geometrically non-linear theory is used to study the dynamic behavior of a thin-walled composite beam. The model is based on a small strain and large rotation and displacements theory, which is formulated through the adoption of a higher-order displacement field and takes into account shear flexibility (bending and warping shear). In the analysis of a weakly nonlinear continuous system, the Ritz?s method is employed to express the problem in terms of generalized coordinates. Then, perturbation method of multiple scales is applied to the reduced system in order to obtain the equations of amplitude and modulation. In this paper, the non-linear 3D oscillations of a simply-supported beam are examined, considering a cross-section having one symmetry axis. Composite is assumed to be made of symmetric balanced laminates and especially orthotropic laminates. The model, which contains both quadratic and cubic non-linearities, is assumed to be in internal resonance condition. Steady-state solution and their stability are investigated by means of the eigenvalues of the Jacobian matrix. The equilibrium solution is governed by the modal coupling and experience a complex behavior composed by saddle noddle, Hopf and double period bifurcations.","palabras_clave":"Shear flexibility|Internal resonance|Composite material|Thin-walled beams"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1105,"idioma_id":4,"titulo":"Influence of geometry on stratification and segregation phenomena in bidimensional piles","resumen":"We present a numerical study of the flow segregation problem in bidimensional piles. To  simulate the pile formation, we employ a pseudo-dynamics method. The model allows us to vary the  concentration of big and small grains present in the pile and the size ratio between them. The different  segregation patterns arising after the pile is finished are studied by analyzing the spatial distribution of  the grains. Two different segregation indices are defined and evaluated over the piles. The contact  network of the final configuration of grains in the pile is also determined. The conditions under which  the different segregation patterns show up are discussed. A comparison with a previous experimental  study is performed for all the numerical results obtained in the present paper. The advantages and  limitations of the simulation model are also discussed.","palabras_clave":"pile|segregation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1106,"idioma_id":4,"titulo":"First report of  Enterocytozoon bieneusi from dairy cattle in Argentina.","resumen":"Fecal specimens were obtained from a total of 70 dairy calves less than two months old on 11 municipalities in Buenos Aires, Argentina. After removal of fecal debris by sieving and sucrose flotation, specimens were subjected to PCR to detect the presence of Enterocytozoon bieneusi. PCR revealed a 14.3% of prevalence for E. bieneusi with 10 positive calves from 7 municipalities. Gene sequence analysis conducted in all samples positives by PCR revealed the presence of six genotypes; four previously reported in cattle as well as humans (D, I, J, and BEB4), one never reported in cattle before but previously reported in humans (EbpC), and one novel genotype (BEB10). These results constitute the first molecular characterization of E. bieneusi in Argentina, and suggest a potential risk of zoonotic transmission in this area","palabras_clave":"Argentina|Cattle|Enterocytozoon bieneusi|Microsporidia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1107,"idioma_id":4,"titulo":"'Holocene (~4.5-1.7 cal. kyr BP) paleoenvironmental conditions in central Argentina inferred from entire-shell and intra-shell stable isotope composition of terrestrial gastropods'","resumen":"The isotopic fingerprint of terrestrial gastropods is progressively used as a credible natural paleoenvironmental archive. Most published work has used this proxy at tropical and temperate latitudes of the Northern Hemisphere, and has concentrated on entire-shell analysis. The present study provides entire-shell and intra-shell isotopic profiles to infer both average and seasonal late Holocene environmental conditions in central Argentina (30°S ). Shells of Plagiodontes daedaleus  (Gastropoda: Odontostomidae) were collected from the Alero Deodoro Roca-Sector B site, one of the few archeological sites in central Argentina rich in shells collected by pre-Hispanic hunter-gatherer groups. Ancient entire shells exhibited values that were ~2.5?higher in &#948;13C and ~1.8? higher in &#948;  O than modern individuals, pointing to higher abundance of C 4 plants and overall drier conditions  ( lower relative humidity and\/or higher rain &#948;18O) during 4.5-1.7 cal. kyr BP than today, in agreement with published regional proxies. Intra-shell isotopic profiles suggest that modern and fossil specimens deposited their shells throughout two-to-three summer\/winter cycles. Intra-shell &#948;O values varied ~5?, matching with the seasonal variation of rain &#948;O values. The extent of seasonality was similar during 4.5-1.7 cal. kyr BP and today. Intra-shell &#948;13C values varied ~2-3?and did not portray distinct seasonal cycles, depicting minimal seasonal variations in the snail diet. This work illustrates that South American terrestrial gastropods have great potential for Paleoenvironmental studies.","palabras_clave":"terrestrial gastropods|stable isotopes|paleoenvironment|Holocene|Ongamira|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1113,"idioma_id":4,"titulo":"Encapsulation of citral in formulations containing sucrose or trehalose: emulsions properties and stability","resumen":"The performance of formulations for citral encapsulation by spray drying was assessed.   Focus was put on the emulsions properties and stability. Formulations contained   sucrose or trehalose with or without maltodextrin and a modified starch as emulsifier.  Viscosity, molecular mobility, microstructure, droplet size distribution, and stability were   analyzed before and after spray-drying. Instability processes operated in the emulsions   bulk, being flocculation the main one. Droplet size and viscosity influenced the   emulsions stability. An increase in viscosity attained by the addition of MD delayed the   global destabilization processes. Emulsion properties and stability were similar between   the formulations containing sucrose or trehalose. Also, there were no differences   regarding aroma retention or sensorial perception of citral. The mixture of maltodextrin   and trehalose presented higher Tg values allowing to maintain the glassy state of the   powder in broader temperature and relative humidity conditions. Trehalose presented a   promising performance as an ingredient in the carrier formulation to encapsulate citric   flavors.","palabras_clave":"CITRAL|EMULSIONS|ENCAPSULATION|SPRAY DRYING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1117,"idioma_id":4,"titulo":"Pachyrhizus ahipa roots and starches: composition and functional properties related to their food uses","resumen":"Chemical composition of two accessions (N°11 and Local) of Pachyrhizus ahipa was evaluated and their starches were characterized from a technological and nutritional point of view. Ahipa roots were characterized by their high protein (8-9%) level compared to other roots and tubers. Accession 11 exhibited higher starch content than Local accession. Compared to cassava, ahipa starch showed lower gelatinization temperature, exhibiting accession 11 the lowest value. Ahipa starch digestibility was similar to that of other leguminous plants. Accession 11 showed higher rapidly digestible (RD) and resistant and lower slowly digestible (SD) starch than cassava. Rotational rheological assays indicated that gelatinized ahipa starch suspensions present a pseudoplastic thixotropic behavior and under dynamic assays they behaved as a weak gel. Finally, ahipa can be considered a very good source of starch and might be used as a functional food, contributing to increase the RD and SD fractions.","palabras_clave":"Leguminous tuberous roots|Ahipa accessions|Root chemical composition|Rotational and dynamic rheological assays|Starch digestibility"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1118,"idioma_id":4,"titulo":"d13C and d15N Characterization of Modern Huemul (Hippocamelus bisulcus) from the Patagonian Andean Forest. Scope and Limitations of Their Use as a Geographical Marker","resumen":"This paper presents an isotopic characterization (d13C and d15N) of modern huemul from Patagonian Andean forest. This deer is considered an endemic species, now inhabiting the sub-Antarctic forest of Chile and  Argentina. We analyse if the isotopic signals of the modern huemuls can be used as geographic markers on two distinct spatial scales. Firstly, on the intra-forest level, we analyse the relation between the d13C and  d15N of the huemul and the annual precipitation in the place in which the sample was collected. Secondly, on the inter-environmental level, we evaluate to what extent the huemul s isotopic signal differs from that of  the guanaco (Lama guanicoe), an herbivore that occupies Patagonia s continental steppe. The results reveal that, on the one hand, there is no relation between the isotopic values of modern huemules and precipitation  levels, whereas on the other hand, the modern huemul is different from the guanaco in both isotopes. We believe that this difference between the herbivores is associated with the isotopic signals at the base trophic  chain, which is influenced by the precipitation gradient. In this way, even though for now, these isotopic markers turn out not to be useful for differentiating between huemuls coming from sectors of the forest with  marked differences in precipitation, it is possible to distinguish herbivores coming from the forest and steppe of continental Patagonia, enabling the use of d13C and d15N as geographic markers. The isotopic characterization of d13C and d15N of the modern huemuls and its relation to the Patagonian Andean forest has strong implications for paleoecological and archaeological aspects of this environment, including the biogeographical history of the huemul, and in order to the test the models of use and exploitation of the forest by huntergatherers in the past.","palabras_clave":"carbon|Hippocamelus bisulcus|Holocene|hunter-gatherer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1125,"idioma_id":4,"titulo":"The use of soy protein polymers as a release device for nematophagous fungi in the control of parasitic nematodes in ruminants","resumen":"This trial was conducted to evaluate the predatory activity of Duddingtonia flagrans incorporated into soy protein-based polymers as a controlled-release device (CRD). The rate of fungal release from the polymers and time of residence of the CRD in the rumen of a cannulated sheep was also determined. After administration to the sheep, the CRD was extracted at weekly intervals over a month for observation of its physical structure and faeces were collected to observe the subsequent predatory activity of the fungus in Petri dishes with water-agar 2% and Panagrellus spp. as bait. The CRD slowly degraded in the rumen over 4 weeks and liberated D. flagrans into the faeces. The formulation of the soy protein-based polymers did not affect the predatory activity of the fungus. The study demonstrates that biodegradable soy protein polymers could potentially improve the use of nematophagous fungi for controlling nematode parasites of ruminants.","palabras_clave":"biological control|nematophagous fungi|Duddingtonia flagrans|controlled-release device"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1129,"idioma_id":4,"titulo":"Expression of FaXTH1 and FaXTH2 genes in strawberry fruit. Cloning of promoter regions and effect of plant growth regulators","resumen":"Xyloglucan  endotransglycosylase\/hydrolase  (XTH)   enzymes  are  involved  in   the   remodeling   of   plant  cell  wall  hemicelluloses.  With  the   aim   to   study   the   involvement  of   XTHs  in   strawberry  fruit  ripening,  two  cDNAs  (FaXTH1   and   FaXTH2 )  coding  putative   XTH  proteins   were  cloned  and   the   expression  level  of   both  genes   was   analyzed  on  different  plant  tissues  and   during  ripening  of   three   cultivars  that   differ  in   fruit firmness:  Camarosa   and   Selva  (both   firm  cultivars)   and   Toyonoka   (soft  cultivar).  Bioinformatics   and   phy-logenetic   analysis   suggest   that   FaXTH1   would  have  xyloglucan  endo-transglycosylase   (XET)   as  exclusive activity,   while  FaXTH2   could   be  either   a  strict   XET   enzyme   or  have  both  XET\/XEH  (xyloglucan   endo-hydrolase)  activities.   The   expression  profile  of   FaXTH1   was  similar  during  ripening  of   the   three   cultivars analyzed;   and   a  low   transcript   amount   was   detected  in   early  ripening  stages   (LG   and   W)  coinciding with  a  high  diminution  of   fruit  firmness.  Nevertheless,  the   expression  level  of   FaXTH1   was   significantly higher  during  ripening  in   all  stages   in   Camarosa   and   in   LG,  W  and   100%  R  in   Selva,   in   comparison   to the   softer   cultivar   (Toyonoka).   On  the   other  hand,   not  significant   differences  on  FaXTH2   expression  lev-els were  detected  during  strawberry  fruit  ripening  and   between  cultivars.  These   results  suggest   that FaXTH1 and   FaXTH2   might  play  different  roles  on  hemicellulose   metabolism  and   fruit  softening   in   straw-berry.   In   addition,  promoter  regions   of   both  genes   were  cloned  and   the   effect   of   plant  growth  regulators on  FaXTH1   and   FaXTH2   gene  expression  was   evaluated.   FaXTH1   and   FaXTH2   gene  expression  was sig-nificantly  up-regulated  when  fruit  were  treated   with  gibberellic   acid   and   abscisic   acid,  and   when  the endogenous   source  of   auxins  was   removed.   On  the   other  hand,   the   expression  of   both  genes   decreased significantly   in   fruit  treated   with  ethylene  while  the   opposite  situation  was   observed  in   fruit  treated   with 1-methylcyclopropene   (1-MCP),  an  inhibitor  of   ethylene  perception.","palabras_clave":"STRAWBERRY|SOFTENING|XTH|PLANT GROWTH REGULATOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1131,"idioma_id":4,"titulo":"The gap gene Krüppel of Rhodnius prolixus is required for segmentation and for repression of the homeotic gene sex comb-reduced","resumen":"The establishment of the anterior?posterior segmentation in insects requires the concerted action of a hierarchical gene network. Here, we study the orthologue of Krüppel gap gene in the hemipteran Rhodnius prolixus (Rp-Kr). We characterized its structure, expression pattern and function. The genomic sequence upstream of the Rp-Kr transcriptional unit shows a putative regulatory region conserved in the orthologue genes from Drosophila melanogaster and Tribolium castaneum. Rp-Kr expression is zygotic and it is expressed in the anterior half of the embryo (the posterior half of the egg) during the blastoderm stage and germ band formation; later, during germ band extension, it is expressed in a central domain, from T2 to A3. The Rp-Kr loss of function phenotypes shows disrupted thoracic and abdominal segmentation. Embryos with weak segmentation phenotypes show homeotic transformations, in which an ectopic tibial comb, typical of T1 leg, appears in T2, which correlates with the ectopic expression of Rp-sex-comb reduced in this leg.","palabras_clave":"Rhodnius|Krüppel|gap gene|segmentation|hox regulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1138,"idioma_id":5,"titulo":"Estudios cariotípicos en Flourensia (Asteraceae) de Argentina","resumen":"      En Argentina crecen 12 especies  del género americano Flourensia DC. En su zona central habitan seis, todas  endémicas de dicha región. Se conoce el número cromosómico de la mayoría de las  especies, pero no hay estudios cariotípicos. Por ello, se estudiaron los  cromosomas mitóticos de las seis especies centro-argentinas, realizando un  análisis cualitativo y cuantitativo de sus cariotipos. Se realizaron preparados  permanentes de ápices radicales con técnicas clásicas. Todas las especies  presentaron 2n=36: tres de ellas con 14 pares m + 4 sm y las restantes con 12  pares m + 6 sm. La longitud cromósomica promedio varió entre 2,11 y 2,97 micras,  habiéndose encontrado diferencias estadísticas en las variables C, Lt, R y A1.  Excepto en F. campestris, se encontró uno o dos pares de satélites que variaron  en su ubicación. Los datos obtenidos tienen valor taxonómico ya que se han  encontrado diferencias entre casi todas las especies; además, sugieren que su  especiación habría sido acompañada por pequeños cambios cromosómicos causados  por inversiones y\/o translocaciones.  ","palabras_clave":"Argentina central|Asteraceae|cariotipo|citogenética|Flourensia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1143,"idioma_id":4,"titulo":"Cognitive and motor perturbations in elderly with longstanding diabetes mellitus","resumen":"Type 2 diabetes mellitus is a chronic disease characterized by insulin resistance; inflammation; oxidative stress; vascular damage; and dysfunction of glucose, protein, and lipid metabolisms. However, comparatively less attention has been paid to neurologic alterations seen in elderly individuals with type 2 diabetes. We review clinical, metabolic, and biochemical aspects of diabetic encephalopathy (DE) and propose that quality of dietary lipids is closely linked to DE. This implies that preventive nutritional interventions may be designed to improve DE.","palabras_clave":"Cognitive and motor perturbations|eldery patients|diabetes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1152,"idioma_id":4,"titulo":"'A novel approach to explain the inactivation mechanism of Escherichia coli employing a commercially available peracetic acid'","resumen":"The chemical inactivation of Escherichia coli employing a commercial mixture of peracetic acid (PAA) was studied. For this purpose, experiments were carried out using dilutions of the unmodified mixture, and also the same mixture but altered with hydrogen peroxide (HP) previously inhibited.         Also, these results were compared to those obtained before employing HP alone. It was found that the mixture is much more efficient than HP and PAA acting separately. Furthermore, it was found that PAA without HP is much more efficient than HP alone. A plausible explanation is presented. The homolysis of PAA would give rise to a chain reaction that generates a significant number of highly oxidizing radicals. An attacking scheme to bacteria in two stages is proposed, where the initial step, mainly caused by PAA, is very fast and eliminates some specific components of the bacteria that would otherwise inhibit the parallel action of HP. Thereafter, the emergence of a potentiating synergetic action of the second oxidant seems to be immediately unveiled.","palabras_clave":"COMMERCIAL PERACETIC ACID|ESCHERICHIA COLI|HYDROGEN PEROXIDE|SYNERGISM|WATER DISINFECTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1158,"idioma_id":4,"titulo":"YEASTS FROM KEFIR GRAINS: ISOLATION, IDENTIFICATION, AND PROBIOTIC CHARACTERIZATION","resumen":"Kefir?a traditional beverage whose consumption has been associated with health benefits?is a logical natural product to investigate for new probiotic strains. The aim of the present work was to isolate and identify kefir yeasts and select those with acid and bile tolerance to study their adhesion to epithelial cells and their transit through mouse gut. From 4 milky and 3 sugary kefir grains, 34 yeast strains were isolated and identified by means of classical microbiological and molecular-genetic methods (whole-cell protein pattern, internal-transcribed-spacer amplification, and analysis of restriction-fragment?length polymorphisms). We identified 4 species belonging to 3 genera?Saccharomyces cerevisiae (15 strains), Saccharomyces unisporus (6 strains), Issatchenkia occidentalis (4 strains), and Kluyveromyces marxianus (9 strains)?and selected 13 strains on the basis of resistance to low pH and bile salts. Among the strains selected, Kluyveromyces marxianus CIDCA 8154 and Saccharomyces cerevisiae CIDCA 8112 were further studied. Both strains evidenced the capacity to adhere to epithelial intestine-derived cells in vitro and to survive passage through the gastrointestinal tract of BALB\/c mice. The investigation of the potential probiotic features of these kefir-yeast strains should be useful for the development of novel functional foods.","palabras_clave":"Probiotics.|Yeasts.|Saccharomyces|Kluyveromyces"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1166,"idioma_id":4,"titulo":"Isolation and characterization of indigenous Streptomyces and Lentzea strains from soils containing boron compounds in Argentina","resumen":"The Salta Province ? in the northwest of Argentina ? is the main worldwide producer of  hydroboracite and leads in exports of boron mineral and its derivatives in Latin America. In  addition to the natural presence of boron compounds in the soils, there are others contaminated  due to the boron mining industry. Although some bacteria are known to require boron for their  growth or to be capable of storing boron, no studies have been published about Streptomyces or  Lentzea genera?s capacity to tolerate high boron concentrations, or about their metabolic capacities  in boron contaminated environments. The results of this research show the isolation and molecular  characterization of eight strains belonging to the actinobacteria phylum collected from different  soils contaminated with high boron concentration in Salta state. The boron tolerance assays, which  show that three of the strains were able to tolerate up 60?80 mMboron, demonstrate the potential  capability of this group of bacteria to grow and maybe to remove boron from the environment.  They appear to be promising, considering that these microorganisms are infrequent pathogens, are  metabolically versatile and many Streptomyces can synthesize boron containing metabolites.","palabras_clave":"Streptomyces|Lentzea|contaminated soils|boron compounds"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1174,"idioma_id":4,"titulo":"Study of pulsed light induced damage on Saccharomyces cerevisiae in apple juice by flow cytometry and transmission electron microscopy.","resumen":"This work analyzed the pulsed light (PL) (0.0?71.6 J\/cm2)-induced damage on Saccharomyces cerevisiae KE162 cells in peptone water (pH 3.5 or 5.6) and apple juice (pH 3.5) by applying flow cytometry (FCM) and transmission electronic microscopy. Cells were labeled with fluorescein diacetate (FDA) for detecting membrane integrity and esterase activity and with propidium iodide (PI) for monitoring membrane integrity. S. cerevisiae inactivation curves reached 6?7 log reductions (peptone water systems) and 3.9 log reductions (apple juice) after 60 s (71.6 J\/cm2) of PL exposure. FCM revealed the same damage pattern (although at different doses) in all media: at low doses, there was an increase in population in PI+&#8722;FDA+ quadrant, while at high doses, most of the population was located at quadrant PI+?FDA&#8722;, indicating that PL provoked rupture of the cytoplasm membrane allowing PI to penetrate cells and there was progressive loss of esterase activity. Comparison of conventional culture technique with FCM revealed the occurrence of certain cell subpopulations in peptone water with pH 3.5 which were stressed and lost their ability to grow in agar but still showed metabolic activity. Transmission electron microphotographs of PL-treated cells clearly indicated that various cell structures other than plasma membranes were altered and\/or destroyed in a different degree depending on exposure time and type of medium.","palabras_clave":"PULSED-LIGHT|FLOW-CYTOMETRY|MICROSCOPY|SACCHAROMYCES CEREVISIAE|APPLE JUICE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1175,"idioma_id":4,"titulo":"Modern microbial mats in siliciclastic tidal flats: Evolution, structure and the role  of hydrodynamics","resumen":"Microbial mats in coastal environments play an important role in both stabilizing the sediment and preserving  sedimentary structures. They represent the first biological systems that appeared on Earth, even forming large  fossils in carbonate settings known as stromatolites. However, microbial mats have also been recognized for  siliciclastic environments as sandy mat structures. In particular, mats are the primary element of the so-called  Microbially-Induced Sedimentary Structures (MISS) and their various types represent very useful proxies for  the interpretation of the environmental conditions in which they were formed.  The objectives of this paper are twofold. The first is to provide a general background review of microbial mats in  tidal flats, including their evolution, structure, and morphology. The second objective is to provide amodern case  study inwhich we examine the role of storms relative to day-to-day tidal currents. Although tidal currents could  be an important eroding factor, we demonstrate that waves, no matter their magnitude, play a significant role in  developing different types of MISS such as wrinkle structures and eroding mats into flipped-over fragments.  Furthermore, we also show the significance of wave-induced pressure onto groundwater in forming other  types of MISS as Kinneya structures and petee ridges. Knowing the environmental conditions to which presentdaymicrobial  mats are subject and howthey evolve upon drastic changes in those conditions (i.e., stormevents),  represent an important basis for the interpretation of fossil MISS.","palabras_clave":"SEDIMENTARY STRUCTURES|MISS|WAVE SHEAR STRESS|TIDAL CURRENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1179,"idioma_id":4,"titulo":"Bacteria isolated from roots and rhizosphere of Vitis vinifera retard water losses, induce abscisic acid accumulation and synthesis of defense-related terpenes in in vitro cultured grapevine","resumen":"ver adjunto","palabras_clave":"PGPR|TERPENES|ABA|GRAPE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1182,"idioma_id":4,"titulo":"Efficiency of cytogenetic methods in detecting a chromosome rearrangement induced by ionizing radiation in a cultivated chili pepper line (Capsicum baccatum var. pendulum - SOLANACEAE)","resumen":"Purpose : The present study was designed to locate transient  chromosome aberrations on a selected pepper cultivar and  determine the tracing effi ciency of different cytogenetic methods.  Materials and methods: Seeds from Capsicum baccatum var. pendulum  cultivar ?Cayenne? were treated with an acute dose of X-rays  (300 Gy) and chromosome aberrations were analysed by different  cytogenetic methods [Feulgen, silver staining for nucleolus organizer  regions (silver positive nucleolus organizing regions or AgNOR), fl uorescent  banding, fl uorescence in situ hybridization (FISH) and meiotic  analysis].  Results: A rearranged chromosome carrying two nucleolus organizing  regions (NOR) induced by ionizing radiation was detected in the  cultivar, with the occurrence of a small reciprocal exchange between  a chromosome of pair no. 1 and another chromosome of pair no. 3,  both carrying active NOR in short arms and associated chromomycin  A positive \/ diamidino - phenylindole negative (CMA+\/DAPI-) heterochromatin.  Meiotic analysis showed a quadrivalent confi guration,  confi rming a reciprocal translocation between two chromosomes.  Conclusions: The use of X-rays in Capsicum allowed us to develop  and identify a pepper line with structural rearrangements between  two NOR-carrying chromosomes. We postulate that all the cytological  techniques employed in this research were effi cient in the search for  chromosome aberrations. Particularly, Feulgen and AgNOR were the  most suitable in those cases of transient rearrangements, whereas  fl uorescent banding and FISH were appropriate for intransitive ones.","palabras_clave":"CAPSICUM| IONIZING RADIATION| CHROMOSOME ABERRATIONS|CYTOGENETIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1185,"idioma_id":4,"titulo":"Essentials oils of some Mentha spp. and their relation with antimicrobial activity against Paenibacillus larvae, the causative agent of American foulbrood in honey bees, by using the bioautography technique","resumen":"Essential oils of three mint species (Mentha aff. arvensis, Mentha aff. rotundifolia and a probably feral hybrid of Mentha spp.) were investigated for their antimicrobial properties against Paenibacillus larvae (White). The bioactivity of the oils was compared using the combination of in vitro techniques such as microdilution, agar dilution and bioautography. The chemical composition of the oils was analyzed by GC\/MS. Using the bioautography assay, menthol, menthone, menthofuran and piperitone oxide were found to be responsible for the antimicrobial activity of these oils. A quantitative structure-activity relationship (QSAR) model was developed for four terpenoids with significant antimicrobial activity using Hyperchem 8.0 and Gaussian 03 software. The QSAR approach leads to a better understanding of the structural properties of these terpenoids which are responsible for bioactiv-ity. The present work reports the first systematic study about the use of QSAR properties to correlate antimicrobial activity of natural substances against P. larvae.","palabras_clave":"ACEITES EENCIALES |VARROA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1186,"idioma_id":5,"titulo":"El frente orogénico activo de los Andes Centrales a la latitud de la ciudad de Mendoza (32°50´-33°S).","resumen":"Current active front of the Central Andes comprises part of the western piedmont of the city of Mendoza, where more than 800,000 people are established. Despite this, a comprehensive study of active faults mainly as potential seismogenic sources is lacking in this crucial sector of the Andean foreland. The present study attempts to outwit this shortcoming by characterizing the main Quaternary structures and integrating them in a structural-kinematic model developed from three balanced structural cross-sections. The foreland deformation at the study area is characterized by a population of N-S to NNE striking reverse faults, whose detachment level will be located in the Pre Silurian basement, constituting a thick skin thrust front. The series of thrusts, rooted at a 9-10 km-depth detachment, corresponds to Melocotón and Divisadero Largo faults showing surficial expression, and a blind fault called Maure, inferred from the structural-kinematic model. The Maure blind fault transfers shortening to the west-vergent thin-skinned Cerro de la Gloria thrusts, thus forming a triangular deformation zone. According to morphometric features of these active faults, a probable maximum earthquake magnitude ranges from Mw 5.4 to 6.8. Furthermore, strike slip faults with NW-SE strike are cutting Cerro de la Gloria fault system. Results were contrasted with ground data and focal mechanisms of surficial local earthquakes. ","palabras_clave":"sismicidad|ciudad de Mendoza|fallas activas|modelo cinemático"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1188,"idioma_id":4,"titulo":"Assessment of precision in ionospheric electron density profiles retrieved by GPS radio occultations","resumen":"The Constellation Observing System for Meteorology Ionosphere and Climate (COSMIC) is a six satellite radio occultation mission  that was launched in April 2006. The close proximity of these satellites during some months after launch provides a unique opportunity  to evaluate the precision of Global Positioning System (GPS) radio occultation (RO) retrievals of ionospheric electron density from  nearly collocated and simultaneous observations. RO data from 30 consecutive days during July and August 2006 are divided into  ten groups in terms of daytime or nighttime and latitude. In all cases, the best precision values (about 1%) are found at the F peak height  and they slightly degrade upwards. For all daytime groups, it is seen that electron density profiles above about 120 km height exhibit a  substantial improvement in precision. Nighttime groups are rather diverse: in particular, the precision becomes better than 10% above  different levels between 120 and 200 km height. Our overall results show that up to 100?200 km (depending on each group), the uncertainty  associated with the precision is in the order of the measured electron density values. Even worse, the retrieved values tend sometimes  to be negative. Although we cannot rely directly on electron density values at these altitudes, the shape of the profiles could be  indicative of some ionospheric features (e.g. waves and sporadic E layers). Above 200 km, the profiles of precision are qualitatively quite  independent from daytime or latitude. From all the nearly collocated pairs studied, only 49 exhibited a difference between line of sight  angles of both RO at the F peak height larger than 10. After analyzing them we find no clear indications of a significant representativeness  error in electron density profiles due to the spherical assumption above 120 km height. Differences in precision between setting  and rising GPS RO may be attributed to the modification of the processing algorithms applied to rising cases during the initial period of  the COSMIC mission.","palabras_clave":"GPS radio occultation|Electron density|Uncertainties"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1192,"idioma_id":4,"titulo":"Attribution of carbon dioxide fluxes to crop types in a heterogeneous agricultural landscape of Argentina","resumen":"The increasing proportion of agricultural landsworldwide makes it necessary to intensify the researchconcerning the carbon exchange at agricultural sites. In orderto determine the Net Ecosystem Exchange (NEE) in an agriculturallandscape in the province of Buenos Aires, Argentina,we carried out eddy covariance measurements with a fluxtower, which was placed between two agricultural fields.Therefore, the measured CO2 flux represents the accumulatedflux from both areas, i.e., from different crop types. We herepresent an analysismethod which attributes the flux to the twocrop types. For this analysis, we applied the Hsieh footprintmodel to identify the contributing source area to the fluxmeasurement. We then applied a multiple regression analysisto calculate the NEE in the growing season 2011\/2012 foreach field separately. The pronounced differences in the timecourses of the CO2 fluxes in the two fields can be explained bythe different sowing times and different growth stages of bothcultivations. The time courses furthermore show that the CO2uptake of the plants was strongly affected by the droughtwhich lasted from December 2011 to January 2012. For thegrowth cycle of maize (216 days), the NEE was &#8722;240 g C m&#8722;2and for the growth cycle of soybean (154 days) &#8722;231 g C m&#8722;2.In order to obtain the NEE of a complete agricultural cycle(from harvest to harvest), we also considered the NEE ofautumn and winter 2011. Uncertainties of the spatiallypartitioned NEE are quantified and discussed.","palabras_clave":"CARBON DIOXIDE FLUX|EDDY COVARIANCE MEASUREMENTS|FOOT PRINT MODEL|HETEROGENEOUS LAND COVER|MAIZE|SOYBEAN|DROUGHT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1195,"idioma_id":4,"titulo":"Atypical surface behavior of ceramides with nonhydroxy and 2- hydroxy very long-chain (C28-C32) PUFAs","resumen":"Unique species of ceramide (Cer) with very-long-chain polyunsaturated fatty acid (VLCPUFA), mainly 28-32 carbon atoms, 4-5 double bonds, in nonhydroxy and 2-hydroxy forms (n-V Cer and h-V Cer, respectively), are generated in rat spermatozoa from the corresponding sphingomyelins during the acrosomal reaction. The aim of this study was to determine the properties of these sperm-distinctive ceramides in Langmuir monolayers. Individual Cer species were isolated by HPLC and subjected to analysis of surface pressure, surface potential, and Brewster angle microscopy (BAM) as a function of molecular packing. In comparison with known species of Cer, n-V Cer and h-V Cer species showed much larger mean molecular areas and increased molecular dipole moments in liquid expanded phases, which suggest bending and partial hydration of the double bonded portion of the VLCPUFA. The presence of the 2-hydoxyl group induced a closer molecular packing in h-V Cer than in their chain-matched n-V Cer. In addition, all these Cer species showed liquid-expanded to liquid-condensed transitions at room temperature. Existence of domain segregation was confirmed by BAM. Additionally, thermodynamic analysis suggests a phase transition close to the physiological temperature for VLCPUFA-Cers if organized as bulk dispersions","palabras_clave":"Ceramide|PUFA|Langmuir Monolayer|Biological membrane"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1203,"idioma_id":4,"titulo":"Work functions maps and surface topography characterization of nitroaromatic-ended dendron films on graphite","resumen":"Surface topography and work function maps were simultaneously obtained for carbon surfaces modified by a dendritic molecule: 3,5-Bis (3,5-dinitrobenzoylamino) benzoic acid. The dendrons were spontaneously assembled onto highly ordered pyrolytic graphite samples, exhibiting an increase in the surface potential. This fact is consistent with the incorporation of an electron-acceptor functional group that remains electroactive on the surface. ","palabras_clave":"DENDRON|SELF-ASSEMBLY|KELVIN PROBE FORCE MICROSCOPY|ATOMIC FORCE MICROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1207,"idioma_id":4,"titulo":"Kinetics of the liquid phase selective hydrogenation of 2,3-butanedione over new composite supported Pd catalysts","resumen":"BACKGROUND:  Heterogeneous hydrogenation catalysts for fine chemical synthesis are a convenient alternative to homogeneous catalysts because of the ease of separation and reuse. In order to be good catalysts they must have high activity and selectivityand good mechanical properties. Appropriate kinetic models should also be available for reactor design.  Novel composite supported Pd catalysts were synthesized and tested in the liquid-phase selective hydrogenation of 2,3-butanedione to 3-hydroxy-2-butanone (acetoin). The composite support comprised a mixture of an organic polymer and&#947;-Al2O3. The support and the Pd catalyst were further characterized by XRD, SEM, EMPA and XPS spectroscopy. Catalytic tests at various conditions were performed in order to elucidate the kinetics of the system.  RESULTS: The composite had better mechanical properties (resistance to radial and axial compression) in comparison withother commercial supports. Good activity and high selectivity to acetoin, a product of partial hydrogenation, were obtained at different reaction conditions. A Langmuir?Hinshelwood chemical rate expression useful for reactor design was regressed fromthe kinetic data.  CONCLUSIONS: The experimental results could be explained by a Horiuti?Polanyi mechanism in which the addition of an H atom to the carbonyl group in the adsorbed state is the rate limiting step.","palabras_clave":"SELECTIVE HYDROGENATION|2,3-BUTANEDIONE|COMPOSITE|KINETIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1210,"idioma_id":4,"titulo":"Dehydroepiandrosterone and Metyrapone partially restore the adaptive humoral and cellular immune response in endotoxin immunosuppressed mice","resumen":"Prior exposure to endotoxins renders the host temporarily refractory to subsequent endotoxin challenge (endotoxin tolerance). Clinically, this state has also been pointed out as the initial cause of the non-specific humoral and cellular immunosuppression described in these patients. We recently demonstrated the restoration of immune response with mifepristone (RU486), a receptor antagonist of glucocorticoids. Here we report the treatment with other modulators of glucocorticoids, i.e. dehydroepiandrosterone (DHEA), a hormone with anti-glucocorticoid properties, or metyrapone (MET) an inhibitor of corticosterone synthesis. These drugs were able to partially, but significantly, restore the humoral immune response in immunosuppressed mice. A significant recovery of proliferative responsiveness was also observed when splenocytes were obtained from DHEA- or MET-treated immunosuppressed mice. In addition, these treatments restored the hypersensitivity response in  immunosuppressed mice. Finally, although neither DHEA nor MET improved  the reduced CD4 lymphocyte count in spleen from immunosuppressed mice, both treatments promoted spleen architecture reorganization, partially restoring the distinct cellular components and their localization in the spleen. The results from this study indicate that DHEA and MET could play an important role in the restoration of both adaptive humoral and cellular immune response in LPS-immunosuppressed mice, reinforcing the concept of a central involvement of endogenous glucocorticoids on this phenomenon.","palabras_clave":"glucocortioids|immunosuppression|mice|restoration"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1214,"idioma_id":4,"titulo":"Agricultural suitability and fertility in occidental piedmont of Calchaquíes Summits (Tucuman, Argentina)","resumen":"Our study area is located in the piedmont of Calchaquíes Summits (Tucuman Province, Northwest Argentina). The objectives of this paper are to improve the knowledge of Pre-Hispanic agricultural practices on landscape and soils, and to provide new knowledge about land fertility of agricultural areas, taking into account the environmental settings. Physical and chemical features, such as structure, texture, pH, calcium, organic and inorganic phosphorus, and available copper, manganese, and iron were taken into account. After photointerpretation and field surveys, two agricultural terraced geomorphological units were sampled. Samples were made in comparable off-site locations and the archaeological sites. After Principal Component Analysis, physicochemical analysis showed that texture is the most significant difference between the two archaeological sites. Agricultural practices introduced high chemical variations, despite the substantial differences between agricultural and off-site profiles. This is the first approach of this nature in Northwest Argentina.","palabras_clave":"Pre-Hispanic agriculture|Pedology|Soil chemistry|Formative period"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1215,"idioma_id":4,"titulo":"Cherry fibers isolated from harvest residues as valuable dietary fiber and functional food  ingredients","resumen":"Residues discarded at cherry fruit harvesting were extracted with ethanol from 'Chelan', 'Brooks' and 'Sunburst' varieties to obtain cherry fibers constituted by the cell wall polysaccharides, applicable as functional food ingredients, additives and\/or dietary fibers. Powder properties were evaluated. The highest specific volume, directly related to sample porosity, corresponded to ´Brooks´ fibers. These results matched the best hydration properties showed by ´Brooks´. Chemical composition may indicate a hydrogel microstructure for cherry fibers. ´Chelan´ and ´Sunburst´ powders showed the highest total phenolics content, 40-63% of them were bound. The FRAP-antioxidant activity determined in water was lower than that expected from the total phenolics content determined after alkaline or acid hydrolysis. Cherry fibers stabilized oil-in-water (fi= 50%) emulsions and showed foaming capacity. Beyond some differences observed between varieties, cherry harvesting residues constitute valuable sources of biopolymers and antioxidant compounds potentially useful as functional food ingredients and dietary fiber.","palabras_clave":"FUNCTIONAL CHERRY FIBERS|PECTINS|PHENOLICS|ANTIOXIDANT CAPACITY|EMULSION STABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1225,"idioma_id":4,"titulo":"Two amplicon sequencing strategies revealed different facets of the prokaryotic community associated with the anaerobic treatment of vinasses from ethanol distilleries","resumen":"The prokaryotic consortium from a pilot-scale UASB reactor fed with vinasses from ethanol distilleries was evaluated by means of amplicon sequencing of the 16S rRNA gene. Two different sets of primers targeted to overlapping regions of the V4-16S region were used to gain a broad picture of such community and to perform a comparative analysis. From the two datasets obtained, prevalent phyla were Firmicutes, Verrucomicrobia and Thermotogae. Interestingly, one set of primers captured variability in both the bacterial and archaeal portions of the community, whilst the other one revealed a more diverse community structure, but only in the Bacteria domain. Although a certain level of agreement between the two strategies was observed, sharp differences indicate that different facets of the community were disclosed by each approach.","palabras_clave":"ANAEROBIC DIGESTION|VINASSES|16S RRNA PYROSEQUENCING|COMMUNITY PROFILING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1230,"idioma_id":4,"titulo":"Should apple snail Pomacea canaliculata (CAENOGASTROPODA, AMPULLARIIDAE) be used as bioindicator for BDE-209?","resumen":"Abstract Apple snail Pomacea canaliculata has been report-  ed to accumulate polybrominated diphenyl ethers (PBDEs) and  was recently proposed as PBDE bioindicator. This work inves-  tigates the ability of P. canaliculata to accumulate BDE-209 by  dietary exposure under controlled experimental conditions. A  30-day long enrichment feeding assay was carried out using 30  adult apple snails, placed in individual aquaria. Food was  enriched at three BDE-209 concentrations (400, 4,700, and  8,300 &#956;g g&#8722;1 lipid weight). Correlation between BDE-209  values in food and snail tissue were estimated according to  Stockholm Convention suggested criteria for chemicals with  KOW >5. All animals survived with no evident physical alter-  ations, and all of them accumulated BDE-209. BDE-209 levels  in tissue samples increased exponentially with the exposure  concentration. The bioaccumulation factor vs. food concentra-  tion plot showed a peculiar pattern, in which at intermediate  concentrations the snails accumulated less BDE-209 than  expected. Our results suggest that P. canaliculata would pres-  ent a detoxification mechanism for BDE-209 different from the  most commonly reported metabolic pathways.","palabras_clave":"POMACEA CANALICULATA|BIOINDICATOR|POLIBROMINATED DIPHENIL ETHERS|BDE-209"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1246,"idioma_id":4,"titulo":"Formation kinetics and microestructure of Mg-Ti hydrides made by reactive ball milling","resumen":"In this work we report the formation kinetics and microstructural properties of Mg1&#8722;xTix powder metal hydride systems (x = 0.1, 0.2, 0.3, 0.4, 0.5), obtained by reactive ball milling (RBM) via three different ways. The resulting MgH2?TiH2 nanocomposites are characterized and an optimal composition is found. Differences among the preparation routes are analyzed.","palabras_clave":"Hydrogen storage|Reactive milling|Nanocomposites|Nanostructures"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1272,"idioma_id":5,"titulo":"Nuevos acercamientos al espacio semipúblico durante el Período Medio (s. VII-XII D.C.). Caracterización y estudio de un patio en La Rinconada.","resumen":"            En  este trabajo presentamos una caracterización y análisis  del espacio semipúblico del sitio ceremonial de La Rinconada, ubicado  temporalmente en el Período Medio (s. VII-XII DC) en el Valle de Ambato,  Catamarca. Centramos nuestro estudio en los restos materiales más abundantes,  conjuntos cerámicos y faunísticos, de uno de los patios mayores del  emplazamiento, la Estructura 5, continuando con la idea de profundizar en su  conocimiento. A partir del análisis cerámico se establece que las piezas  estuvieron habilitadas para participar en un contexto de actividades múltiples,  asociadas con el almacenamiento y el transporte de  sustancias; pautando, en algunos casos, espacialmente las actividades. Con  respecto a la fauna, hay evidencia de que todas las  etapas de procesamiento principalmente de camélidos  se habrían llevado a cabo allí y que tales animales habrían ingresado enteros al patio para luego distribuirlos,  de manera relativamente homogénea, entre las habitaciones para su consumo final.  Considerando la totalidad de los conjuntos analizados es posible identificar  una mayor cantidad y variedad de actividades desarrolladas en el ámbito  semipúblico caracterizando este espacio como un lugar de paso obligado y de control  del acceso a otros espacios, lugar integrador de los distintos ámbitos en un  contexto de interacciones sociales.                ","palabras_clave":"LA RINCONADA|ESPACIO SEMIPUBLICO|CONJUNTOS CERAMICOS Y FAUNISTICOS|PERIODO MEDIO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1281,"idioma_id":4,"titulo":"Pd-like controllers for delayed bilateral teleoperation of manipulators robots","resumen":"This paper proposes a compensated PD-like controller for delayed bilateral teleoperation of a manipulator robot. The scheme has a PD-like remote controller, a damping into the master, and a compensation strategy. The proposed compensation removes part of potential energy of the user's command depending on the difference between the situation on the remote site and the situation as perceived by the human operator. In addition, the stability of the delayed teleoperation system is analyzed, and a comparison based on experiments is carried out in order to analyze the advantages of using the proposed compensation. Finally, results of a bilateral teleoperation including the proposed control scheme, where the master and slave exchange information by using a low-cost connection of mobile Internet, are shown.","palabras_clave":"Robot Teleoperation|Force feedback|Time Delay"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1304,"idioma_id":4,"titulo":"Short communication: Plasma concentration of glucose-dependent insulinotropic polypeptide may regulate milk energy production in lactating dairy cows","resumen":"In dairy cows, an increase in plasma concentration of glucose-dependent insulinotropic polypeptide (GIP) is associated with an increase in metabolizable energy intake, but the role of GIP in energy partitioning of dairy cattle is not certain. The objective of this study was to examine the relationship between plasma GIP concentrations and energy partitioning toward milk production. Four mid-lactation, primiparous, rumen-fistulated Holstein-Friesian cows were fed a control diet of 55% forage and 45% concentrate [dry matter (DM) basis] in a 4×4 Latin square design with 4-wk periods. The 4 treatments were (1) control diet fed at 1000 and 1600h, and (2) once-daily (1000h) feeding, (3) twice-daily (1000 and 1600h) feeding, and (4) 4 times\/d (1000, 1600, 2200 and 0400h) feeding of the control diet plus 1 dose (1.75kg on a DM basis at 0955h) into the rumen of supplemental vegetable proteins (Amino Green; SCA NuTec Ltd., Thirsk, UK). Measurements of respiratory exchange and energy balance were obtained over 4d during the last week of each period while cows were housed in open-circuit respiration chambers. Blood was collected from the jugular vein every 30min for 12h, using indwelling catheters, starting at 0800h on d 20 of each period. Plasma GIP concentration was measured in samples pooled over each 5 consecutive blood samplings. The relationships between plasma GIP, DM intake, heat production, respiratory quotient (RQ), milk yield, and milk energy output were analyzed using linear correlation procedures, with metabolizable intake as a partial variant. Plasma GIP concentration was not correlated with heat production, or milk yield, but was positively correlated with milk energy yield (correlation coefficient=0.67) and negatively correlated with RQ (correlation coefficient=-0.72). The correlations between GIP with RQ and milk energy output do not imply causality, but support a role for GIP in the regulation of energy metabolism in dairy cows.","palabras_clave":"dairy cow|energy partitioning|glucose-dependent insulinotropic polypeptide|milk energy output"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1310,"idioma_id":4,"titulo":"Use of IAEA's phase-space files for the implementation of a clinical accelerator virtual source model","resumen":"In the present work, phase-space data files (phsp) provided by the International Atomic Energy Agency (IAEA) for different accelerators were used in order to develop a Virtual Source Model (VSM) for clinical photon beams. Spectral energy distributions extracted from supplied phsp files were used to define the radiation pattern of a virtual extended source in a hybrid model which is completed with a virtual diaphragm used to simulate both electron contamination and the shape of the penumbra region. This simple virtual model was used as the radiation source for dosimetry calculations in a water phantom. The proposed model proved easy to build and test, and good agreement with clinical accelerators dosimetry measurements were obtained for different field sizes. Our results suggest this simple method could be useful for treatment planning systems (TPS) verification purposes.","palabras_clave":"RADIOTHERAPY|MONTE CARLO|PHASE-SPACE|IAEA|VIRTUAL SOURCE MODEL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1317,"idioma_id":5,"titulo":"Educación y territorio en el SO misionero: la escuela secundaria obligatoria en el contexto  rural","resumen":"Este artículo analiza la obligatoriedad de la escuela secundaria, sancionada en Argentina en el año 2006, considerando las características que ha asumido en los contextos rurales del sudoeste de la Provincia de Misiones. Analizaremos cómo la posibilidad de acceder al nivel medio, la elección de la escuela secundaria en sus distintas orientaciones y la finalización los estudios, se articula con la formación en el trabajo rural desde las proyecciones de futuro urbano y\/o rural de adultos y jóvenes.    Presentamos resultados de un trabajo etnográfico iniciado en 2009 con los alumnos de grados superiores de una escuela primaria rural localizada a 4 km de la ciudad de San Ignacio. Acompañando el progreso de los egresados en estos cinco años, ampliamos el trabajo de campo a una escuela secundaria agrícola, así como a otros establecimientos de educación media de la zona. Asimismo visitamos los predios familiares y entrevistamos a referentes locales, ya que esta indagación se centra en las experiencias formativas en el trabajo rural de las jóvenes generaciones, y su relación con la propuesta educativa formal en relación al conocimiento del mundo agrario.","palabras_clave":"EDUCACIÓN RURAL|ESCUELA MEDIA|TERRITORIO|CONOCIMIENTO AGRÍCOLA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1319,"idioma_id":4,"titulo":"Amaranth Milling Strategies and Fraction Characterization by FT-IR","resumen":"Amaranth nutritional value has been widely recognized, but the required conditions for its processing cannot be adapted to traditional technologies. For the proposal of alternative strategies, the changes of several components should be understood. Enriched starch and lipid-protein fractions of amaranth flour upon different milling treatments were obtained and characterized by attenuated total reflectance-Fourier transform-infrared spectroscopy. Starch- and lipid-protein-enriched amaranth fractions were obtained by abrasive milling; amaranth starch was isolated by wet-milling procedure, and flour samples were obtained from planetary ball milling. Changes on starch, protein, and lipids relative contents, on starch crystallinity and on lipids and protein stability after milling and 6-month storage, were evaluated. The Fourier transform-infrared (FT-IR) spectroscopy peaks of the main grain components were identified in the middle-infrared range. By calculating the ratios between height intensities of selected specific peaks, several characteristics of the samples could be explained: increased protein content and lipid proportion of the enriched fraction; decrease of the starch crystallinity degree by abrasive milling and especially by ball milling due to starch amorphization during these processes; and lipids modification in milled and in 6-month aged samples. FT-IR analysis can be considered a rapid, nondestructive, solvent-free, sensitive, and useful tool to investigate starch, lipid, and protein modifications provoked by processing and storage as well as to determine, based on intensity ratio, the relative proportion of grain components within amaranth milling fractions. The abrasive milling associated to planetary ball milling to obtain modified different fractions is presented as an interesting strategy for the processing of amaranth grain. © 2013 Springer Science+Business Media New York.","palabras_clave":"Planetary ball milling . |Amaranth starch . |Energy function .|Crystallinity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1326,"idioma_id":5,"titulo":"Prácticas interdisciplinarias en Juegotecas y escuelas de barrios vulnerados","resumen":"El presente trabajo se realizó en el marco del Proyecto de Investigación UBACyT 2012-2015 Actitudes hacia el juego infantil y modalidades de apego en adultos en enlace con el Programa de Extensión Universitaria Juegotecas Barriales y UBANEX Un mundo, una salud; todos de la Universidad de Buenos Aires.  El trabajo en terreno se desarrolla en un jardín de infantes de una Fundación de Villa Soldati y Juegotecas implementadas en Centros de Salud y Acción Comunitaria (CeSAC), ubicados en barrios vulnerados de la Ciudad Autónoma de Buenos Aires.  Se actúa desde la interdisciplinariedad -como herramienta que enriquece todo abordaje- de las prácticas ya que los miembros del equipo trabajan con cada comunidad y su problemática específica, coordinando talleres de reflexión con padres, encuentros con docentes y juegotecas para niños.  Por lo tanto, el objetivo de este artículo es dar cuenta del trabajo interdisciplinario en las juegotecas donde se facilita el juego (y de esta forma el desarrollo de los niños) y a su vez, se propone reflexionar sobre la función del juego en la institución escolar.","palabras_clave":"juegoteca|escuela|barrios vulnerados|interdisciplina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1347,"idioma_id":4,"titulo":"Effects of extrusion conditions on physical and nutritional properties of extruded whole grain red sorghum (sorghum spp)","resumen":"In order to analyze the effects of extrusion temperature (T: 164, 182, 200  C) and grits moisture content (g\/100 g sample) (%M: 14, 16.5, 19) on textural and physicochemical properties of red sorghum extrudates, whole grain flour was extruded according to a factorial experimental design. The higher values for specific mechanical energy consumption (1006.98 J\/g) and expansion (3.36) were obtained at 164 C?14%M and for sensorial hardness at 164 C?19%M.While for specific volume, the highest value (10.41 cm3\/g) was obtained at 200 C?14%M. Water solubility and water absorption were directly related with T and inversely with M. Microscopic observation of the samples indicates that the greatest cooking degree was obtained at 200 C?4%M and the lowest at 164 C?19%M. Extrusion at 182 C?14%M allows obtaining an expanded product with good properties. Proximal composition did not show statistically significant differences with raw sample. Extruded sample showed a 25.4% reduction of available lysine and a 31% increase in protein digestibility.","palabras_clave":"Extrusion|Physicochemical properties,|red sorghum|red sorghum, whole grain"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1350,"idioma_id":4,"titulo":"Diabetes in South and Central America: An update","resumen":"The estimated population of the South and Central America (SACA) Region is 467.6 million and 64% is in the age range of 20?79 years but the population pyramid and age distribution are changing. The average prevalence of diabetes in the Region is 8.0% and is expected to reach 9.8% by the year 2035. Prevalence is much lower in rural settings than in urban and the differences attributed to lifestyle changes may be a target for intervention. The indigenous population is a particularly vulnerable group needing special attention. On average, 24% of the adult cases with diabetes are undiagnosed but in some countries this is still as high as 50%. Health expenditure due to diabetes in the Region is around 9% of the global total. Inadequate glycemic control, defined as HbA1c >7%, is a strong predictor of chronic complications which increase resource use in the Region and less than half of the patients enrolled in diabetes care programmes are at target. Fifty percent or more of the adult population is overweight\/obese and around one third of the adult population has metabolic syndrome using regional cutoffs for waist circumference. The number of people with IGT is almost equal to those with diabetes presenting an additional challenge for prevention. Children with type 1 diabetes represent only 0.2% of the total population with diabetes but the incidence may be increasing. In many places they have limited access to insulin, and even when available, it is not used appropriately. The available epidemiological data provide the background to act in developing national diabetes programmes which integrate diabetes care with cardiovascular prevention and promote diabetes prevention as well.","palabras_clave":"diabetes|South and Central America|glycemic control|prevalence"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1358,"idioma_id":4,"titulo":"Non-equilibrium thermo- dynamics and entropy production spectra: A tool for the characteriza- tion of ferrimagnetic materials.","resumen":"An analysis of entropy production and its evolution in the frequency domain upon application of electromagnetic fields to ferrimagnetic material has been investigated. The spectral entropy of NiZn ferrites doped with different amount of Yttrium has been studied by numerical simulation. The system under the application of an oscillating electromagnetic field is out of equilibrium, since there is entropy production due to the dielectric and magnetic polarization. A system under the application of an electromagnetic fields E (&#969;) and H (&#969;) atconstant temperature T has been considered. For the numerical simulation of the behavior of the entropy production due to the magnetic relaxation, experimental data have been correlated to a recent publishedcausality model. For the entropy production due to dielectric relaxation, experimental data have been used.Entropy production related to magnetic response could be associated with two mechanisms: domain wall motion and spin rotation. Entropy production related to dielectric processes could be associated with thedelay of the different components of the polarizability as a function of the frequency of the applied field and the correlation with the transport charge mechanism in the material. At the studied frequency range theentropy production due to the dielectric relaxation is negligible. Thus entropy spectra could be a suitable tool for the analysis of the ferrimagnetic materials.","palabras_clave":"entropy|ferrites|electromagnetic|material"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1367,"idioma_id":4,"titulo":"Egg parasitism of Piezodorus guildinii  and Nezara viridula  (Hemiptera: Pentatomidae) in soybean, alfalfa and red clover.","resumen":"Piezodorus guildinii Westwood and   Nezara viridula (L.) (Hemiptera: Pentatomidae)   are important soybean pests. P. guildinii causes   more injury and is less susceptible to insecticides   compared to N. viridula. N. viridula egg parasitoids   are well studied; however, little is known about   parasitoids of P. guildinii. Alfalfa, soybean   and red clover were sampled during several   seasons to characterize the abundance of both   stink bugs, to determine their egg parasitoids,   and to estimate parasitoids impact. In the field,   Telenomus podisi (Ashmead),Trissolcus urichi  (Crawford) and Trissolcus basalis (Wollaston)   (Hymenoptera: Platygastridae) emerged from  P. guildinii, while only T. basalis (Wollaston)   (Hymenoptera: Platygastridae) emerged from  N. viridula. The proportions of parasitized eggs   (i. e., the parasitoid impact) and egg masses,   as well as the number of parasitized eggs\/total   number of eggs of the parasitized egg masses,   were similar for alfalfa and soybean. Parasitism   was not observed in red pclover. Parasitoid   impact was lower during the dry growing   seasons. Although P. guildinii field parasitism   by T. urichi was less significant, laboratory   experiments from the bibliography indicate that   this wasp species performs well on this host.   Trissolcus urichi would be an important biological   control agent against P. guildinii, principally when   the stink bug is more abundant.","palabras_clave":"Telenomus podisi |field parasitism |Trissolcus urichi  |Trissolcus basalis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1386,"idioma_id":5,"titulo":"COMPACTACIÓN DE UN SUELO ARGIUDOL TÍPICO POR TRÁFICO EN UN SISTEMA DE PRODUCCIÓN DE FORRAJES","resumen":"Entre los diversos procesos que conducen al deterioro de la estructura del suelo, la compactación inducida por tráfico vehicular pareciera ser uno de los desafíos más importante, para una agricultura sustentable. Para un suelo dado, la distribución de la compactación en el perfil es principalmente función de la textura, la carga aplicada, la presión en el área de contacto, el contenido de humedad y la intensidad de tráfico recibida, siendo esta última particularmente alta en los sistemas de producción de forrajes. Con el objetivo de valorar el efecto del tráfico vehicular de un tractor 2WD con una carga total de 3810 kg sobre algunas propiedades físicas del suelo y la producción de forraje de una pradera, se realizó un ensayo sobre un Argiudol típico bajo labranzaconvencional con los siguientes tratamientos: 5 pasajes del tractor; 3 pasajes del tractor; y un tercer tratamiento (testigo) sin tráfico. Para cuantificar el efecto del tráfico, se midió: infiltración sobre la superficie del suelo; resistencia a la penetración, desde la superficie hasta los 600 mm; densidad aparente en dos profundidades, 0 -100 mm y 100-200 mm; y materia seca a los 3, 7y 12 meses posteriores al tráfico. Los valores de resistencia a la penetración fueron significativamente mayores para los tratamientos con tráfico, presentando incrementos en todas las profundidades e instancias de medición. Las mayores diferencias se evidenciaron para la primera medición en los primeros 100 mm, con un incremento de 152% para el tratamiento de 5 pasadasy de 140% para el de 3 pasadas. La resistencia a la penetración es un parámetro más sensible a los efectos del tráfico vehicular. Las mayores intensidades de tráfico provocan disminuciones en el rendimiento de materia seca de la pradera. El uso de tractores de bajo peso por eje en los sistemas de cosecha de forrajes constituye una alternativa que reduce pero no elimina los aspectosadversos del tráfico sobre la impedancia mecánica del suelo y la productividad de la pradera.","palabras_clave":"RESISTENCIA A LA PENETRACIÓN|DENSIDAD APARENTE|INFILTRACIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1396,"idioma_id":4,"titulo":"Long-term biopermanence of ceramides, cholesteryl esters, and ether-linked triglycerides with very-long-chain PUFA in the cadmium-damaged testis","resumen":"Cadmium is known to harm rat testis by causing the dose-dependent apoptotic or necrotic death of seminiferous epithelium cells. Here we investigated how this affects the lipids with long-chain (C18-C22) and very-long-chain (C24-C32) polyunsaturated fatty acids (VLCPUFA) typical of spermatogenic and Sertoli cells. A severe acute inflammatory reaction resulted from the massive necrotic death of these cells two days after a single high (4 mg\/kg) dose of CdCl2. This led to the conversion of most testicular glycerophospholipids to diradylglycerols (DRG) and free fatty acids (FFA) and of most sphingomyelins to ceramides (Cer). By day 30 the testis weight had decreased three fold. The DRG and FFA had been metabolized but, unexpectedly, ceramides persisted. Also slow to disappear were VLCPUFA-containing triacylglycerols from former germ cells and ether-linked triglycerides and cholesteryl esters (CE) from former Sertoli cells. Similar results were observed 30 and 45 days after administering repeated small non proinflammatory CdCl2doses (1 mg\/kg). At day 30 after both treatments, an amorphous material replaced the original seminiferous tubules and testicular macrophages populated the interstitium. Species of CE and etherlinked triglycerides containing fatty acids other than VLCPUFA steadily accumulated in the irreversibly damaged testis, a manifestation of the activity of phagocytic cells. The long-term permanence of original VLCPUFA-containing neutral lipids, especially ceramides, indicates that these cells were slow to clear out the acellular material contained in seminiferous tubules, pointing to a form of silent chronic inflammation as an additional outcome of the multifactorial commotion caused in the testis by experimentally administered cadmium.","palabras_clave":"CERAMIDES|CHOLESTERYL ESTERS|ETHER-LINKED TRIGLYCERIDES |CADMIUM-DAMAGED TESTIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1426,"idioma_id":4,"titulo":"High speed electric motors based on high performance novel soft magnets","resumen":"                              Novel Co-based soft magnetic materials  are presented as a potential substitute for electrical steels in high speed  motors for current industry applications. The low losses, high permeabilities,  and good mechanical strength of these materials enable application in high rotational  speed induction machines. Here we present a finite element analysis of Parallel  Path Magnetic Technology rotating motors constructed with both silicon steel  and Co-based nanocomposite. The later achieved a 70 % size reduction and an 83  % reduction on NdFeB magnet volume with respect to a similar Si-steel design.  ","palabras_clave":"ELECTRIC MOTORS|SOFT MAGNETS|FINITE ELEMENTS|HITPERMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1433,"idioma_id":5,"titulo":"Análisis económico del uso de Drones para la generación de mapas de prescripción de malezas","resumen":"Los contratistas de maquinaria agrícola ocupan un rol central en la actual estructura productiva. Su intervención en las labores agrícolas se ha incrementado en los últimos años, teniendo en la actualidad una participación muy activa. Desde hace más de 7 años el Instituto de Ingeniería Rural de INTA investiga sobre la temática. Se presentan aquí algunos de los resultados.","palabras_clave":"DESARROLLO AGROINDUSTRIAL|RENTABILIDAD|ANÁLISIS DE EVOLUCION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1443,"idioma_id":5,"titulo":"ALEACIONES Al-Cu: ESTRUCTURAS DE SOLIDIFICACIÓN Y COMPORTAMIENTO ELECTROQUÍMICO","resumen":"El objetivo del presente trabajo es estudiar el comportamiento frente a la corrosión de las  aleaciones Al-1%Cu, Al-4,5%Cu y Al-15%Cu. Se evaluaron las propiedades de acuerdo al tipo de  estructura (columnar C, equiaxial E o con transición de columnar a equiaxial TCE) y a la  composición. Se realizaron medidas de polarización potenciodinámicas cíclicas y ensayos de  espectroscopia de impedancia electroquímica, en solución de NaCl al 3% y a temperatura  ambiente. No se evidenció una correlación directa entre la estructura y la resistencia a la corrosión.  En las observaciones microscópicas se evidenció corrosión localizada en la zona dendrítica. Se  considera que las zonas ricas en cobre actúan como cátodo, aumentando la disolución del  aluminio. Se obtuvieron diagramas de impedancia al potencial de corrosión y se simularon  mediante un modelo de circuito equivalente, observándose que los valores","palabras_clave":"aluminio |cobre|resistencia a la corrosión |espectroscopía de impedancia electroquímica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1472,"idioma_id":5,"titulo":"Agaricales del Chaco Oriental 1. Primer registro de Tetrapyrgos nigripes (Marasmiaceae) y Xeromphalina tenuipes (Mycenaceae) para la region","resumen":"se describen e ilustran a Tetrapyrgos nigripes y Xeromphalina tenuipes, registros nuevos para la región del Chaco Oriental, de estas dos especies pantropicales. Tetrapyrgos nigripes se caracteriza por su píleo centralmente estipitado con esporas tetraédricas y pileipellis con estructuras rameales, mientras que X. tenuipes presenta el píleo amarillento a ocráceo anaranjado, laminillas amarillas más claras y estípite marrón rojizo cubierto por abundantes pelos que le dan un aspecto aterciopelado.  Palabras Clave: Basidiomycota, hongos lignícolas, Reserva Natural Educativa Colonia Benítez, diversidad.","palabras_clave":"BASIDIOMYCOTA|HONGOS LIGNICOLAS|RE COLONIA BENITEZ |DIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1475,"idioma_id":5,"titulo":"Incidencia de las interacciones verbales en la producción de discursos argumentativos infantiles","resumen":"En el presente trabajo presentaremos los principales resultados de la investigación  Desarrollo de competencias para la producción de discursos argumentativos: interacciones verbales en el aula de primaria, que se concretó en la Universidad Nacional de Cuyo. Los objetivos propuestos fueron: a- Describir  la incidencia de las interacciones verbales en el aula   en los discursos argumentativos -orales y escritos- producidos por niños de tercer año de educación primaria. b-Relacionar las estrategias verbales en la interacción áulica, lideradas por el docente y los pares más competentes,  con el   desarrollo de habilidades de producción de discursos argumentativos en los sujetos estudiados, desde un modelo  socio-constructivista. En esta investigación se estudió el rol del docente y de un par más aventajado en la construcción del conocimiento, desde una perspectiva histórico-cultural. Entre los principios básicos que la sustentan podemos mencionar: a-  concebir el aula como un escenario de construcción y negociación conjunta de significados: b- tener en cuenta la incidencia del contexto en la construcción del conocimiento; c- considerar las características particulares que el discurso educacional adquiere en la interacción docente-alumno, alumno-alumno en el aula. Los resultados de este estudio nos permitieron establecer un conjunto de indicadores para caracterizar la incidencia de las interacciones verbales áulicas en el  desarrollo de habilidades de producción de discursos argumentativos  en alumnos que cursan tercer grado de la escuela primaria.","palabras_clave":"PRODUCCION ESCRITA|ARGUMENTACION|INTERACCIONES VERBALES|EDUCACIÓN PRIMARIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1479,"idioma_id":4,"titulo":"Response of benthic macroinvertebrates to gradients in hydrological connectivity: a comparison of temperate, subtropical, Mediterranean, and semiarid river floodplains","resumen":"1. Despite a general recognition that benthic macroinvertebrates respond to changes in hydrological  connectivity within floodplain ecosystems, no consensus about patterns in community structure  and ecosystem processes across large scales and different climates has yet been established. Such  knowledge is necessary since anthropogenic activities continue to alter the natural hydrogeomorphology  of large floodplains, with most consequences for aquatic communities remaining  unknown.  2. Using information from six large rivers located in four different climate regions (humid subtropical,  maritime temperate, Mediterranean and dry semi-arid), we compared benthic macroinvertebrate  responses along lateral gradients of hydrological connectivity. We tested hypotheses related to  differences among climate regions and to similar hydrological constraints within any one climate.  The large geographical scale covered by this study provides the first comprehensive comparison of  aquatic community patterns across hydrological gradients under different climatic settings.  3. Multivariate ordinations demonstrated a higher overlap of trait community composition (50%  variance explained by the first two axes) than taxonomic composition (15%) among floodplains,  displaying high interclimate trait stability. The taxonomy-based ordination separated the subtropical  floodplain, with an average 86% of non-insect taxa, from the insect-dominated temperate, Mediterranean  and semi-arid floodplains (with >50% insect abundance). In the trait-based ordination, large  body size (60% of organisms >4 cm) and long lifespan duration (80% of organisms) discriminated  the subtropical from the other five studied floodplains.  4. Across a gradient of lateral connectivity, linear mixed effect (LME) models supported seven of 15  hypotheses, which suggests remarkably consistent macroinvertebrate patterns in floodplains regardless  of the climate regime. Taxon and trait richness were positively related and peaked at sites of  intermediate hydrological connectivity. Our predictions about the feeding guilds of macroinvertebrates  (e.g. that shredders and scrapers would be more abundant in connected channels, and  predators and deposit feeders at isolated sites) were more strongly supported by the data than  those about life history (e.g. plurivoltinism and short lifespan would be better represented in connected  channels). This difference was related to the influence of extended periods of hydrological  disconnection as disturbance in addition to flooding.","palabras_clave":"River Habitat Templet,| Paraná River, |Tagliamento River, Rhône River, Ebro River, Murray River, Cooper Creek"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1481,"idioma_id":4,"titulo":"Biopolymeric antimicrobial films: Study of the influence of hydroxypropyl methylcellulose, tapioca starch and glycerol contents on physical properties","resumen":"Mixture designmethodologywas applied to study the effect of different levels of tapioca starch (TS), hydroxypropyl methylcelullose (HPMC), and glycerol (Gly) on the physical properties of biopolymeric films supporting potassiumsorbate (KS; 0.3% w\/w) with the goal of contributing to the development ofmaterials for preventing food surface contamination. Mechanical properties, water vapour permeability (WVP), solubility in water (S) and colour attributes were evaluated on the films. HPMCaddition produced an increase of elasticmodulus (Ec), stressat break (&#963;b) and S. It also decreased the yellow index (YI) values and the strain at break (&#949;b).The studywas deepened using the formulation containing 2.67 g\/100 g of TS, 0.67 g\/100 g ofHPMC, 1.67 g\/100 g Gly and 0.3 g\/100 g KS, observing that it behaved as an effective antimicrobial barrier against Zygosaccharomyces bailii external contamination. Microstructural analysis allowed us to conclude that HPMC incorporation to a TS network decreased roughness of the films and it also increased permeability to oxygen (PO2).","palabras_clave":"edible films|starch and HPMC|potassium sorbate|antimicrobial activity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1496,"idioma_id":4,"titulo":"Negative short-term salt effects on the soybean-B. japonicum interaction and partial reversion by calcium addition","resumen":"The short-term (2 h) effects of salt stress (50 and 150 mM NaCl), on early events of soybean-B. japonicum interaction were analyzed determining the following parameters in root hair with o without calcium addition: deformation, apoplastic superoxide radical production (O2.-), root hair death and sodium\/potassium ion content. We also analyzed whether this short-term salt stress influenced laterformation of crown and noncrown nodules determining number and weight of nodules. The negative effect of salt stress on root hair deformation, O2.- production, ionic homeostasis, root hair death and crown nodulation were attenuated by the addition of 5 mM CaCl2. We also analyzed the expression of pathogenesis-related proteins (PR) PR-1, PR-2, PR-3, and four isoforms of PR-5.The expression of PR-2 increased under saline conditions and decreased in osmotic treatment and saline treatment supplemented with calcium in the presence of the symbiont. The changes in PR-2 expression levels together with the death of root hairs, suggest that this responses could be involved in prevents further infection by symbiont under salinity, with some similarities to plant-pathogen interactions","palabras_clave":"nodule formation|root hair deformation|root hair ionic balance|salinity|Soybean- B. japonicum interaction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1512,"idioma_id":4,"titulo":"OPERATOR IDEALS AND ASSEMBLY MAPS IN K-THEORY","resumen":"Let B be the ring of bounded operators in a complex, separable Hilbert space. &nbsp;For p &gt; 0 consider the Schatten ideal Lp consisting of those&nbsp; operators whose sequence of singular values is p-summable; put S =cup_p L_p. Let G be a group and Vcyc the family of virtually cyclic subgroups. Guoliang Yu proved that the K-theory assembly map&nbsp; H^G _*(E(G; Vcyc);K(S))&nbsp;--&gt; K_*(S[G])&nbsp; is rationally injective. His proof involves the construction of a certain Chern character tailored to work with coeficients S and the use of some results about algebraic K-theory of operator ideals and about controlled topology and coarse geometry.    In this paper we give a different proof of Yu´s result. Our proof uses the usual Chern character to cyclic homology. Like Yu´s, our proof relies on results on algebraic K-theory of operator ideals, but no controlled topology or coarse geometry techniques are used. We formulate the result in terms of homotopy K-theory. We prove that the rational assembly map         H^G_*(E(G,FIN),KH(L_p)) otimes Q --&gt; KH_*(L_p&nbsp;^[G]) otimes Q         is injective. We show that the latter map is equivalent to the assembly map considered by Yu, and thus obtain his result as a corollary.                                ","palabras_clave":"CYCLIC HOMOLOGY|HOMOTOPY ALGEBRAIC K-THEORY|OPERATOR IDEAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1518,"idioma_id":5,"titulo":"Educación de adultos. Algunas concepciones y perspectivas en disputa","resumen":"En este artículo nos proponemos desarrollar líneas de abordaje respecto  de la educación de adultos desde una perspectiva crítica. Situamos desde enfoque histórico a los orígenes y emergencia de la educación de adultos como praxis gestada desde los trabajadores organizados e interpelamos los modos en que los organismos hegemónicos fueron cooptando experiencias y hegemonizando el campo. En segundo lugar desarrollamos algunas líneas que permiten caracterizar la explosión del campo de la EDJA para pasar luego a  preguntarnos  acerca de dicha explosión y las proyecciones que puede tener una praxis situada desde nuestro continente, poniendo sobre la mesa la necesidad de avanzar en pos de una crítica a las praxis coloniales y de apropiarnos de herramientas para cuestionarlas. En este mismo sentido señalamos la existencia de una tradición crítica en América Latina, que en mayor o menor medida y focalizando sus miradas en diferentes aspectos de la opresión colonial pero señalaron críticas y praxis alternativas. Profundizamos en función del trabajo que desarrollamos con trabajadores de fábricas recuperadas en uno de los referentes que consideramos necesario revisar,  José Carlos Mariátegui, marxista peruano que desarrolló experiencias pedagógicas con trabajadores fabriles en el Perú en la década del ?20.","palabras_clave":"Educación de adultos|Políticas |trabajadores|organismos internacionales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":1519,"idioma_id":5,"titulo":"La institucionalización del patrimonio en la Quebrada de Humahuaca. El caso de Purmamarca","resumen":"La Quebrada de Humahuaca fue declarada en el año 2003 como patrimonio de la Humanidad por la UNESCO. No obstante, la institucionalización del patrimonio de este territorio comenzó por lo menos a principios del siglo XX. Dentro del complejo proceso influyeron variadas acciones ?académicas, turísticas, legislativas, entre otras. En esta oportunidad, analizamos los trabajos académicos que se vinculan con la valoración de ciertos objetos, lugares y paisajes. Asimismo, estudiamos las normativas y las acciones de conservación y recuperación de ciertos bienes patrimoniales. Por último, examinamos como se entrecruza el saber experto y el poder político en la institucionalización del patrimonio. Para ello, tomamos como caso de estudio a Purmamarca, una aglomeración quebradeña, que ha sido reconocida como un lugar con elementos de interés histórico y turístico a preservar en diferentes ocasiones, desde comienzos del siglo XX hasta nuestros días.  Este proceso de selección patrimonial y de valoración de los bienes ha tenido distintas etapas y modos de activación patrimonial, se vislumbran tres momentos de selección en la valoración académica y en las normativas: Los objetos ?principalmente arquitectónicos y arqueológicos-, los centros urbanos, y los paisajes. En ese recorrido, algunos objetos y prácticas se han destacado y otros han quedado fuera de la legitimación de los expertos y de las normativas del poder político.","palabras_clave":"SABER EXPERTO|PATRIMONIO|PODER POLÍTICO|PURMAMARCA|QUEBRADA DE HUMAHUACA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2444,"idioma_id":5,"titulo":"La acreditación regional de la calidad universitaria en cuestión: ¿modelos en tensión en América del Sur?","resumen":"Este artículo se centra en el análisis de la política regional de acreditación universitaria del Mercado Común del Sur (MERCOSUR) en vistas a, primero, indagar cómo la política regional se ha difundido a la arena de política interna, generando impactos políticos y cambios institucionales en los Estados Parte (regionalismo regulatorio); y segundo, discutir la orientación de esta política regional.El trabajo se divide en tres secciones: primero, un breve apartado que describe la política de acreditación de la calidad (AC) del MERCOSUR; segundo, una sección analítica en dos niveles: los procesos de articulación y difusión de políticas entre la región y el ámbito doméstico y la identificación de modelos alternativos de AC en el MERCOSUR; tercero, una discusión final sobre el armado de criterios regionales de calidad y procedimientos de evaluación universitaria.","palabras_clave":"ACREDITACION|CALIDAD|EVALUACION|MERCOSUR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2464,"idioma_id":4,"titulo":"PH OF IRRIGATING SOLUTIONS IN CONTACT WITH HUMAN ROOTS DENTIN","resumen":"The aim of this study was to analyze the in vitro behavior of the pH of different irrigating solutions after contact with extracted human teeth either alone or consecutively used. Mandibular human premolars were selected. The middle thirds were divided into 6 parts. The specimens obtained were divided into 6 groups and treated with irrigating solutions: 1) distilled water; 2) 1% NaOCl; 3) 1% Citric Acid (CA); 4) 17% EDTA; 5) 1% CA + 1% NaOCl ; 6) 17% EDTA + 1% NaOCl. Specimens were immersed in 1 mL of each solution at 37ºC, those of groups 1, 2, 3 and 4, for 5 minutes, and the rest, consecutively for 2.5 minutes in each solution. Initial and final pH of the solutions were determined. Data were analyzed by the T Test, one-way analysis of variance (ANOVA) and Tukey multiple comparison Test. At 2.5 and 5 minutes there were significant differences between the initial and final pH for all the solutions. The pH values decreased for distilled water and NaOCl, while they increased for CA and EDTA. In vitro, the pH of all solutions was modified after being in contact with root dentin for both tested times (2.5 and 5 min).","palabras_clave":"PH|IRRIGATING SOLUTIONS|DENTIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2472,"idioma_id":4,"titulo":"Redescription and Palaeoecological significance of the Bryozoan Hippoporidra patagonica (Pallaroni, 1918) in the San Julián Formation (late Oligocene) of Santa Cruz province, Argentina","resumen":"Hippoporidra is a cheilostome bryozoan that predominantly encrusts gastropod shells inhabited by hermit crabs. The genus has a Pan-Atlantic distributionand its fossil record ranges from the Eocene to Holocene. Cellepora patagonica Pallaroni is here transferred to Hippoporidra and its autozooidsand avicularia are described for the first time based on scanning electron microscopy. Hippoporidra patagonica can be distinguished fromthe remaining species of the genus by the peculiar shape of its interzooidal avicularia and the morphology of its orifice, which is semicircular, witha straight proximal border. In addition, many specimens have adventitious avicularia located on a suboral umbo. The record of Hippoporidra patagonica(Pallaroni) in the Gran Bajo Member of the San Julián Formation (late Oligocene) in Patagonia confirms the presence of this genus at thesouthern tip of South America and indicates a Pan-Atlantic distribution during the Cenozoic.","palabras_clave":"Bryozoa|Hippoporidra|San Julián|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2475,"idioma_id":5,"titulo":"La asistencia médica en los ingenios durante el primer peronismo: la resignificación de un viaje debate social","resumen":"En 1946, con la llegada del peronismo al poder, el problema de la salud de los trabajadores azucareros volvió a concitar hondos debates políticos. En noviembre de ese año, el gobernador de la provincia de Tucumán, Carlos Domínguez, envió a la Legislatura un proyecto de asistencia médica, obligatoria y gratuita para los establecimientos laborales que contaran con más de 200 trabajadores, iniciativa que afectaba de forma directa a los ingenios. En dos meses el proyecto se convirtió en ley generando una profunda polémica que recuperó el carácter distributivo del proteccionismo azucarero y las obligaciones sociales de los industriales. En este sentido, la ley obligó a precisar los límites de la responsabilidad de los particulares y del Estado frente al problema sanitario de la agroindustria y contribuyó a articular un entramado de demandas que 'desde arriba' pero también 'desde abajo' posibilitaron la emergencia de la salud en términos de derecho.","palabras_clave":"INGENIOS AZUCAREROS|SALUD|PERONISMO|TUCUMÁN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2476,"idioma_id":4,"titulo":"Biological effects of argentine asbestos.  Mineralogical and   morphological characterisation","resumen":"Asbestiform minerals, namely serpentine  (chrysotile) and amphiboles (tremolite?actinolite) as well as  others of fibrous habit (sepiolite) from Argentine deposits  were characterised to assess their biological hazard. Materials  currently used as asbestos substitutes were also  assessed (glass fibre and ceramic fibre). Studies with laboratory  animals were conducted. Sixty mice (30 females and  30 males), 8 weeks old, were used following the good  practices in the care and handling of laboratory animals.  They were split into six groups of ten mice each (5 females  and 5 males), designated as control, tremolite, glass fibre,  chrysotile, sepiolite and ceramic fibre, and were exposed by  inhalation to these previously ground materials. The animals  were examined throughout the experiments to see how  they responded to the inhaled substances to establish the  effects of inhalation at the time of exposure and once they  had been killed. The respiratory tract (trachea, bronchi and  lungs) of the animals exposed to the different materials was  examined in tissue sections. Differences in the amount of  connective tissue in the lungs and the presence of alveolar  macrophages were observed in the animals exposed to  tremolite, chrysotile and sepiolite, as compared to the  control group. It was concluded that, of all the materials  used, amphiboles caused greater damage and an incipient  development of carcinogenesis. The other ones, especially  chrysotile, produced connective tissue thickening","palabras_clave":"Asbestos \u0002  \u0002  \u0002  |Carcinogenesis|Asbestosis|Amphibole|\u0002 Chrysotile"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2477,"idioma_id":4,"titulo":"Interaction between Human Serum Albumin and antidiabetic compounds and its influence on the O2(1&#61508;g)-mediated degradation of the protein","resumen":"The complexity depicted by disease scenarios as diabetes mellitus, constitutes a very interesting field of study when drugs and biologically relevant components may be affected by such environments. In this report, the interaction between the protein Human Serum Albumin (HSA) and two antidiabetics (Andb), Gliclazide (Gli) and Glipizide (Glip) was studied through fluorescence and docking assays, in order to characterize these systems. On the basis that HSA and Andb can be exposed in vivo at high Reactive Oxygen Species (ROS) concentrations in diabetic patients, the degradative process of the protein free and bound to Andb, in presence of the species singlet molecular oxygen (O2(1&#61508;g)), was evaluated. Fluorescence and docking assays indicated that Gli, as well as Glip bind to HSA on two sites, with binding constants values in the order of 104-105 M-1. Likewise, docking assays revealed that the location of Gli or Glip on the protein may be the HSA binding sites II and III. Thermodynamic parameters showed that the interaction between HSA and Glip is a favored, enthalpically-controlled process. Oxygen uptake experiments indicated that Glip is less photooxidizable than Gli through a O2(1&#61508;g)-mediated process. Besides, the protein-Andb binding produced a decrease in the overall rate constant for O2(1&#61508;g) quenching  as compared to the value for the free protein. This fact could be interpreted in terms of a reduction in the availability of Tyrosine residues in the bonded protein, with a concomitant decrease in the physical quenching deactivation of the oxidative species.","palabras_clave":"Binding|Docking|Photodegradation| Gliclazide|Glipizide|Oxidative stress|Human serum albumin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2480,"idioma_id":5,"titulo":"La rurbanidad en foco. (In) visibilidades en la prensa y la política pública.","resumen":"El trabajo se ocupa de analizar el modo en que los medios y las políticas públicas dan visibilidad a un sector social que resuelve su existencia catando basura mediante el empleo de carros y caballos en la ciudad de Río Cuarto (Argentina). Los carreros o cirujas, entre otras denominaciones, se enfocan aquí como actores rurbanos. Cuando una lente se aproxima a esa realidad, por ejemplo la de los medios de información o la del personal actuante en diversas áreas técnicas del municipio, lo que resalta se resume en no muchas palabras: pobreza, núcleos familiares numerosos, baja instrucción, informalidad, problemas múltiples en y para la ciudad; micro-basurales, riesgo sanitario, contaminación, trabajo infantil, precariedad y riesgo vehicular, entre otros. Frente a este escenario, nos preguntamos: ¿por qué esa trama de cirujeo y rebusque se ve de un modo y no de otro? Y ¿en qué términos se significa e interpreta públicamente? Nuestra presunción es que el modo en cómo se percibe, significa, piensa y actúa sobre esa realidad tiene implicaciones en las políticas sociales que en este caso no consiguen dar respuestas socialmente deseables ante la problemática. Hace falta, entonces, un cambio en su entendimiento.El presente texto se ocupa de mostrar los principales rasgos de la mirada de la prensa local y la política pública, discute sus presupuestos y sentidos instalados y sitúa otra perspectiva. La que proponemos, en rigor, como alternativa para nominar, comprender y promover otras acciones socialmente plausibles.","palabras_clave":"Rurbanidad|Prensa|Políticas públicas|Visibilidades"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2482,"idioma_id":5,"titulo":"Jóvenes, política y sexualidades: los Reglamentos de Convivencia y la regulación de las formas de vestir en la Escuela Secundaria.","resumen":"Este artículo tiene por objetivo analizar las formas de regulación la construcción delcuerpo sexuado de los y las jóvenes que transitan la escuela secundaria de la Ciudadde Buenos Aires. Para ello, en primer lugar, se presentan las distintas tensiones queenfrenta la escuela secundaria a partir del proceso de masificación que la sanción de suobligatoriedad condujo, y se exponen los dilemas que adultos y jóvenes enfrentan ensu cotidianeidad en las instituciones. En un segundo momento, se describe el procesode construcción y consolidación del régimen de convivencia. Y finalmente, se analizanuna serie de escenas de trabajo de campo en una escuela de la jurisdicción cuyo Centrode Estudiantes logra hacer efectivos modificaciones en la vestimenta.","palabras_clave":"JÓVENES|ESCUELA SECUNDARIA|SEXUALIDADES|RÉGIMEN DE CONVIVENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2484,"idioma_id":4,"titulo":"Low Temperature Thermoelectric Power of Ce(Pd 1-x Cu x ) 2 Si 2","resumen":"We present the thermoelectric power  S(T)  of the Ce(Pd 1&#8722;x Cu x ) 2 Si 2  alloy for temperatures  (1.5,mathrm{K} K. We observe three characteristic features across the  (0    substitution range: two positive maxima and a negative minimum, that   are typical for Ce compounds that display, or lie close to, magnetism.   Our analysis of the data shows that the high- T  maximum is related to the Kondo effect on excited crystal-field levels, but that the low- T  one cannot be simply associated with the Kondo scale,  TK .   We speculate that disorder induced by alloying can be at the origin of   this discrepancy and can also be responsible for the low  S(T)  measured at low temperatures in the  (0.2  concentration range. We have extended electrical resistivity measurements on Ce(PdCu)Si 2  ( x=0.5 ) down to  T&#8764;40 &nbsp;mK in applied fields as high as  16 &nbsp;T.","palabras_clave":"Heavy fermions|Antiferromagnetic transition|Thermopower|Electrical resistivity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2485,"idioma_id":4,"titulo":"Ab initio study of the compound-energy modeling of multisublattice structures: The (hP6) Ni2In-type intermetallics of the Ni-In-Sn system","resumen":"The thermodynamic modeling of non-stoichiometric, multisublattice intermetallic phases using the Compound-Energy Formalism (CEF) involves the determination of parameters representing the Gibbs energy (Gm) of binary compounds, the so-called end-member compounds (EMCs), which are often metastable or hypothetical. In current CALPHAD (i.e., Calculation of Phase Diagrams) work, these quantities are  treated as free parameters to be determined by searching for the best fit to the available information in the optimization procedure. The general purpose of this paper is to propose a theoretical approach to the study of the EMCs which makes use of density-functional-theory (DFT) ab initio calculations. The present method is applied to the EMCs involved in the CEF modeling of the non-stoichiometric (hP6) Ni2In-structure type phase of the Ni-In and Ni-In-Sn systems using the three-sublattice models  (Ni)1(Ni,Va)1(In,Ni)1 and (Ni,Va)1(Ni,Va)1(In,Ni,Sn)1, respectively. By means of systematic ab initio projected ugmented waves (PAW) calculations using the VASP code we study the EMCs involved in the EF formulations of the Gm for this phase in the binary and the ternary systems. Specifically, we study the twelve EMCs corresponding to the following sublattice occupations: (Ni)1(Ni)1(In)1, which is usually  described as Ni:Ni:In (i.e., a compound with formula Ni2In), Ni:Ni:Ni (i.e.,Ni3), Ni:Ni:Sn (Ni2Sn), Ni:Va:In (i.e.,NiIn), Ni:Va:Ni (i.e.,Ni2), Ni:Va:Sn (NiSn), Va:Ni:In (NiIn), Va:Ni:Ni (Ni2), Va:Ni:Sn (NiSn), Va:Va:In (In), Va:Va:Ni (Ni), and Va:Va:Sn (Sn). For the listed EMCs, we report the lattice-parameters,  the volume per atom, the electronic density of states and various types of cohesive properties usually taken as macroscopic manifestations of the bonding strength, viz., the bulk modulus and its pressure derivative, the cohesive energy and the energy of formation from the elements. Trends in these quantities are established as a function of the occupation of the various sublattices by the different components and discussed in terms of the interactions between d electrons of the transition element as well  as the hybridization between them and the s and p electrons of the non-transition metal. In addition to the reported thermodynamic information of direct use as input in the CALPHAD optimizations, the picture of the variations in cohesive properties emerging from the present work should be useful in systematizing the thermophysical and structural database for this class of compounds.","palabras_clave":"NI-IN-SN SYSTEM|NI2IN(HP6) SUBLATTICE MODEL|THERMODYNAMIC AND ELECTRONIC PROPERTIES|AB INITIO CALCULATIONS|LEAD-FREE SOLDERING ALLOYS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2486,"idioma_id":5,"titulo":"Experiencias de fertilización en maíz en Tucumán, R. Argentina","resumen":"En el texto","palabras_clave":"No tiene"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2487,"idioma_id":5,"titulo":"CAMINANDO HACIA UNA RESPIRACION SALUDABLE III","resumen":"Las acciones desarrolladas en el proyecto de extensión ?Mejorando la calidad de vida en respiradores bucales?, subsidiado por la Universidad Nacional de La Plata, llevadas a cabo en tres centros educativos de la ciudad de Berisso,  a partir de una metodología participativa interactiva, establecieron vínculos favorables hacia la promoción y prevención de la salud en las distintas comunidades.","palabras_clave":"RESPIRACIÓN|III"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2488,"idioma_id":4,"titulo":"New insights into the Andean crustal structure between 32° and 34°S from GOCE satellite gravity data and EGM2008 model","resumen":"The subduction of the Nazca oceanic plate under the South American plate in the southcentral  Andes region is characterized by the oblique collision of the Juan Fernandez Ridge against  the continental margin. The upper plate is characterized by a broken foreland, a thrust-and-fold belt  and eastward migration of the volcanic arc promoted by the flattening of the slab. Topographic  load, thermal state and plate rheology determine the isostatic state of the continental plate. We calculated  the vertical gravity gradient from GOCE satellite data in order to delineate the main tectonic  features related to density variations resulting from internal and external loads. Then,  using the Bouguer anomaly, we calculated the crust?mantle discontinuity and the elastic thickness  in the frame of the isostatic lithospheric flexure model applying the convolution method approach.  The results obtained show substantial variations in the structure of the continental lithosphere  related to variations in the subduction angle of the Nazca plate. These variations are reflected in  the varying Moho depths and in the plate rigidity, presenting a distinct behaviour in the southern  zone, where the oceanic plate subducts with an approximate ?normal? angle with respect to the  northern zone of the study area where the flat slab occurs.","palabras_clave":"GOCE|Espesor Elastico|Ridge Juan Fernandez|Flat Slab"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2489,"idioma_id":4,"titulo":"Pericarp polypeptides and SRAP markers associated with fruit quality traits in an interespecific tomato backcross","resumen":"The aim of this study was to detect polypeptides and genomic regions associated with fruit quality traits in a backcross generation using as parent the Argentinean cultivated tomato Caimanta of Solanum lycopersicum and the wild accession LA722 of S. pimpinellifolium. We tested two types of molecular marker: polypeptide profile (at two ripening stages, mature green and red ripe) and SRAP (sequence-related amplified polymorphism). A polypeptide of 45 kDa present in the wild parents at the mature green stage was associated with larger fruit and long shelf life. Some amplification fragments from SRAP markers were associated with more than one quality trait such as fruit color, firmness, titratable acidity, and fruit soluble solids content. This study demonstrated for the first time the usefulness of the polypeptide profiles of pericarp and SRAP markers in finding associations with quality fruit traits in a tomato backcross generation.","palabras_clave":"Shelf life|SDS-PAGE|Solanum lycopersicum|Solanum pimpinellifolium"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2491,"idioma_id":4,"titulo":"The Impact of IFN-&#947; Receptor on SLPI Expression in Active Tuberculosis: Association with Disease Severity","resumen":"IFN-g displays a critical role in tuberculosis disease, modulating the innate and adaptive immune responses.  Previously we reported that secretory leukocyte protease inhibitor (SLPI) is a pattern recognition receptor with anti-mycobacterial activity against Mycobacterium tuberculosis (Mtb).  The aim of the present work was to determine whether IFN-g modulated the levels of SLPI in tuberculosis patients.  Plasma levels of SLPI and IFN-g were studied in healthy donors (HD) and tuberculosis (TB) patients.   PBMC from HD and patients with TB or defective IFN-g receptor (IFNGR1*) were stimulated with Mtb-antigen and SLPI and IFN-gR expression were measured.  Both SLPI and IFN-g were significantly enhanced in plasma from TB as compare to HD.   A direct association between SLPI levels and the severity of TB disease was detected.  Besides, Mtb-antigen stimulation decreased the SLPI produced by PBMC from HD but not from TB or IFNGR1* patients.  Neutralization of IFN-g reversed the inhibition of SLPI induced by Mtb-antigen in HD but not in TB patients.  Furthermore, rIFN-g was unable to modify the expression of SLPI in TB patients. Finally, IFN-g expression was lower in TB as compared to HD PBMCs.  These results show that Mtb-induced IFN-g down-modulated SLPI levels by signaling through the IFN-gR in HD.  This inhibitory mechanism was not observed in TB, probably due to the low expression of IFN-g receptor detected in these individuals.","palabras_clave":"TUBERCULOSIS|SLPI|CITOQUINAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2492,"idioma_id":4,"titulo":"A Fraction Containing Kaempferol-3,4&#8242;- dimethylether from Larrea divaricata Cav. Induces Macrophage Activation on Mice Infected with Candida albicans","resumen":"Larrea divaricata Cav. is a plant growing in South America. Both the infusion and a derived fraction (F1) of L.&#8201;divaricata have proved to have immunomodulatory properties. Moreover, F1 can activate macrophages obtained from mice infected with Candida albicans. In this work, F1 was administrated to infected animals, and the state and type of activation of resident macrophages were studied. Results showed that F1 was able to activate macrophages obtained from infected mice by both classical and alternative pathways, probably by inducing a translocation of nuclear factor kappa-B. F1 increases not only the lysosomal activity of macrophages but also the production of phagosomal superoxide anion as a consequence of the activation of the Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) complex. F1 induced an increase in the macrophage capacity to kill the fungus, which was reflected in a decrease in the levels of colonization of organs. A main flavonoid, kaempferol-3,4´-dimethylether, was identified in F1 by HPLC. This compound increased in vitro production of nitric oxide in heat-killed C.&#8201;albicans-stimulated macrophages. The flavonoid could thus be considered one of the responsible molecules mediating the overall effects of F1 on the immune system in infected animals.","palabras_clave":"LARREA DIVARICATA|CANDIDA ALBICANS|MACROPHAGES|KAEMPFEROL-3,4´-DIMETHYLETHER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2494,"idioma_id":4,"titulo":"Electrochemical, HR-XPS and SERS study of the self-assembly of biphenyl 4, 4&#8242;-dithiol on Au (111) from solution phase","resumen":"We report a comparative study of 4,4&#8242;-biphenyldithiol adlayers grown on   Au(111) substrates in solution phase by different methods. Layers   prepared by immersion in solutions of ethanol and n-hexane, with and   without the use of a disulfide reducing agent (tris-carboxyethyl   phosphine, TCEP), were characterized by electroreductive desorption,   impedance spectroscopy, redox activity, high-resolution photoemission   spectroscopy, and surface-enhanced Raman spectroscopy. It is shown that   the simple immersion in an ethanolic solution leads to the formation of,   at least, a bilayer with a high number of SS   bonds. The use of n-hexane as solvent produces a drastic reduction of   these undesired bonds, and a similar result is obtained if the   substrates prepared in the ethanolic solution are then washed with TCEP.   The best results were obtained when the reducing agent was added into   the ethanol solution, in which case all the characterizations were   coincident in the formation of a single layer of standing-up molecules   free of SS   bonds. The charge of the desorption peak and the relative intensity of   the S2p and Au4f photoemission peaks both indicate a surface coverage   &#952;&nbsp;&#8776;&nbsp;0.2. In the case of multilayers formed by immersion in pure   ethanolic solutions, the Raman experiments indicate that intralayer SS bonds are not formed, and hence that all the SS bonds are of the interlayer type.","palabras_clave":"SELF-ASSEMBLED MONOLAYERS|DITHIOLS|ELECTROCHEMISTRY|XPS|SERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2495,"idioma_id":4,"titulo":"Induction of microtubule damage in Allium cepa meristematic cells by pharmaceutical formulations of thiabendazole and griseofulvinNancy","resumen":"Microtubules (MT) are formed by the assembly of - and -tubulins and MT-associated proteins. Wecharacterized the effects of pharmaceutical formulations containing the microtubule disruptors thiaben-dazole (TBZ) and griseofulvin (GF) on the mitotic machinery of plant (A. cepa) meristematic cells. GFconcentrations between 10 and 250 microg\/ml were tested. GF induced mitotic index inhibition and geno-toxic effects, including chromosome fragments, bridges, lagged chromosomes, C-metaphases, tripolarcell division, disorganized anaphases and nuclear abnormalities in interphase cells. Efects on the mitoticmachinery were studied by direct immunofluorescence with -tubulin labeling and by DNA counter-staining with 4,6-diamidino-2-phenylindole (DAPI). Exposure of meristematic root cells to TBZ or GF,100 microg\/ml, caused microtubular damage which led to abnormal MT arrays. Our results suggest thatGF induces abnormalities in spindle symmetry\/polarity, while TBZ causes chromosome missegregation,polyploidy, and lack of cytokinesis.","palabras_clave":"Genotoxicidad|Allium cepa|Pesticidas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2496,"idioma_id":4,"titulo":"CNBP modulates the transcription of Wnt signalling pathway components","resumen":"Cellular nucleic acid binding protein (CNBP) is a small and highly conserved protein with nucleic acid chaperone  activity that binds single-stranded nucleic acids. Data collected so far suggests that CNBP is required for proper  craniofacial development. Despite the advances achieved in the last decade, the identity of themolecular targets  of CNBP responsible for its role in rostral head development remains elusive. In this work we used the  CNBP single-stranded DNA-consensus binding sequence to find out putative CNBP target genes present in  the human, mouse, chicken, Xenopus and zebrafish genomes. Most of the identified genes are associated with  embryonic developmental processes, being three of them(cdk14, ptk7 and tcf7l2)members of the Wnt signaling  pathway. This finding, along with previous one showing that CNBP down-regulates the transcription of Wnt5,  is the aim of our work to address the role of CNBP on the WNT signaling players and pathway regulation.  Experiments carried out in zebrafish developing embryos revealed that craniofacial morphology was more  adversely affected as CNBP abundance decreased. Furthermore, we observed that CNBP up-regulated in a  dose-dependent fashion the transcription of cdk14, ptk7 and tcf7l2, which in turn was reflected in c-myc, ccnd1  and axin2 expression. Results reveal a role of CNBP in transcriptional control of components of theWnt signaling  pathway, which might explain its requirement for proper craniofacial development.","palabras_clave":"tcf7l2|ptk7|cdk14|cnbp|Craniofacial development|Zebrafish"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2497,"idioma_id":4,"titulo":"Novel nelfinavir mesylate loaded d-&#945;-tocopheryl polyethylene glycol 1000 succinate micelles for enhanced pediatric anti HIV therapy: In vitro characterization and in vivo evaluation","resumen":"Worldwide more than 35 million people are living with Human Immunodeficiency Virus (HIV) where 3.3  million are children. This translates in approximately 700 new daily infections in children only in 2012.  Prolonged High Activity Antiretroviral Therapy (HAART) regimes could present low-patient compliance,  especially in children, affecting therapeutic success. Nelfinavir mesylate (NFV) is a non-peptidic HIV-1  protease inhibitor (IP) which was the first IP recommended for pediatric use (>2 years-old). It exhibits  pH-dependant aqueous solubility which results highly restricted at physiological pH values. The former  represents a main clinical limitation due to the reduction on drug absorption along the small intestine  after an oral administration, leading to unpredictable drug bioavailability. Moreover a liquid formulation  of NFV is not available worldwide, preventing appropriate dose adjustment and more convenient  administration. In this framework, the present investigation reports the development of a NFV highly  concentrated aqueous formulation for a more appropriate management of pediatric anti-HIV therapy.  The aim was to encapsulate NFV within d--tocopheryl polyethylene glycol 1000 succinate micelles to  improve its aqueous solubility and its oral pharmacokinetic parameters. Results show that NFV aqueous  solubility was increased up to 80.3 mg\/mL. NFV-loaded micelles exhibited a hydrodynamic diameter of  5.6 nm and a spherical morphology as determined by dynamic light scattering and transmission electronic  microscopy, respectively. In vitro NFV release profile demonstrated a cumulative drug release of  56% at 6 h. Finally, in vivo data showed a significant (p < 0.01) increase of Area-Under-the-Curve between  0 and 24 h for NFV encapsulated in micelles in comparison with a NFV suspension prepared with glycerin  20% v\/v and carboxymethylcellulose sodium 0.5% w\/v, representing an increment on drug oral relative  bioavailability of 1.71-fold. Thereby, this formulation represents an innovative nanotechnological  platform to improve pediatric HIV pharmacotherapy.","palabras_clave":"NELFINAVIR MESILATE ENCAPSULATION|TPGS MICELLES|ORAL BIOAVAILABILITY|PEDIATRIC HIV\/AIDS PHARMACOTHERAPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2498,"idioma_id":4,"titulo":"The Proinflammatory RAGE\/NF-&#954;B Pathway Is Involved in Neuronal Damage and Reactive Gliosis in a Model of Sleep Apnea by Intermittent Hypoxia","resumen":"Sleep apnea (SA) causes long-lasting changes in neuronal circuitry,   which persist even in patients successfully treated for the acute   effects of the disease. Evidence obtained from the intermittent hypoxia   (IH) experimental model of SA has shown neuronal death, impairment in   learning and memory and reactive gliosis that may account for cognitive   and structural alterations observed in human patients. However, little   is known about the mechanism controlling these deleterious effects that   may be useful as therapeutic targets in SA. The Receptor for Advanced   Glycation End products (RAGE) and its downstream effector Nuclear Factor   Kappa B (NF-&#954;B) have been related to neuronal death and astroglial   conversion to the pro-inflammatory neurodegenerative phenotype. RAGE   expression and its ligand S100B were shown to be increased in   experimental models of SA. We here used dissociated mixed hippocampal   cell cultures and male Wistar rats exposed to IH cycles and observed   that NF-&#954;B is activated in glial cells and neurons after IH. To disclose   the relative contribution of the S100B\/RAGE\/NF-&#954;B pathway to neuronal   damage and reactive gliosis after IH we performed sequential loss of   function studies using RAGE or S100B neutralizing antibodies, a herpes   simplex virus (HSV)-derived amplicon vector that induces the expression   of RAGE&#916;cyto (dominant negative RAGE) and a chemical blocker of NF-&#954;B.   Our results show that NF-&#954;B activation peaks 3 days after IH exposure,   and that RAGE or NF-&#954;B blockage during this critical period   significantly improves neuronal survival and reduces reactive gliosis.   Both in vitro and in vivo, S100B blockage altered reactive gliosis but   did not have significant effects on neuronal survival. We conclude that   both RAGE and downstream NF-&#954;B signaling are centrally involved in the   neuronal alterations found in SA models, and that blockage of these   pathways is a tempting strategy for preventing neuronal degeneration and   reactive gliosis in SA.","palabras_clave":"neuroscience|RAGE\/NFkB pathway|sleep apnea|hypoxia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2499,"idioma_id":4,"titulo":"Islet NADPH oxidase activity modulates &#946;-cell mass and endocrine function in rats with fructose-induced oxidative stress","resumen":"Background: Islet NADPH oxidase activity is modulated by glucose and other insulin secretagogues and it might be part of the regulatory mechanism of insulin secretion. We studied its modulatory role of islet NADPH oxidase upon &#946;-cell function in rats with fructose-induced oxidative stress.   Methods: Normal rats were fed for 3 weeks a) a standard diet, b) a fructose-rich diet and c) both diets plus apocynin. We measured plasma glucose, insulin, triacylglycerol and lipid peroxidation levels and the homeostasis model assessment-insulin resistance (HOMA-IR) and HOMA-&#946; indexes, and performed an oral glucose tolerance test. &#946;-cell volume density and the number of islets per mm2 were determined by pancreas immunomorphometric analysis of the pancreas. Insulin secretion, glucose metabolism, glucokinase and NADPH oxidase activities were studied in islets isolated from each experimental group.   Results: Fructose-fed rats had increased plasma triacylglycerol, insulin and lipid peroxidation levels associated to an insulin resistance state; the reactive higher insulin secretion was unable to cope with the increased demand of the hormone, leading to an impaired glucose tolerance. They also have a lower number of islets per area unit with a decreased &#946;-cell volume density. All these alterations were prevented by blocking NADPH oxidase activity with apocynin.   Conclusion: Fructose-induced changes are partly mediated by modulation of NADPH oxidase activity.   General significance: The metabolic dysfunctions and enhanced oxidative stress measured in fructose-fed rats resemble those recorded in human prediabetes; thus, successful strategies employed in this model could be later used to prevent the progression of this state towards type 2 diabetes in human beings.","palabras_clave":"NADPHoxidase|Islet|Insulin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2500,"idioma_id":5,"titulo":"Induccion de callos embriogenicos y formacion de proembriones somaticos en Pterogyne nitens Tull 'Tipa colorada'","resumen":"ResumenPterogyne nitens es un árbol que crece en bosques húmedos del Norte de la Argentina. Por su calidad maderera la especie se utiliza en forestación, reforestación o enriquecimiento de bosques nativos. Una alternativa a los métodos convencionales de propagación son las técnicas de cultivo de tejidos vegetales mediante el uso de la embriogénesis somática.El objetivo del presente trabajo es inducir la formación de callos embriogénicos y la obtención de proembriones somáticos evaluando la influencia del tipo de explanto, tipo y concentración de reguladores de crecimiento y composición del medio basal. Para la inducción de callos embriogénicos se utilizan explantos extraídos de hojas cotiledonares, foliolos, tallos y raíces de plántulas de dos meses de edad. Se emplean tres medios de cultivos MSC, MS50 y MSMOD. Cada medio de cultivo se suplementa con 2,4-D ó ANA en distintas concentraciones. A los 45 días los explantos provenientes de hojas cotiledonaresen los medios de MSC con 2,4-D en concentraciones de 67.87, 107.41, 113.12, 135.74 y 180.99 &#956;M, se logra en mayor proporción la formación de masas callosas amarillas. Con 107.41 &#956;M de 2,4-D en el medio MSC se observa la formación de estructuras&nbsp; proembrionarias. Los segmentos radiculares en todos los tratamientos evaluados, no desarrollan callos. ","palabras_clave":"Tipa colorada|micropropagación| embriogénesis|forestales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2501,"idioma_id":4,"titulo":"Polyphenolic compounds and anthocyanin content of Prosopis nigra and Prosopis alba pods flour and their antioxidant and anti-inflammatory capacities","resumen":"The aim of this study was to determine the content of total free and bound phenolics, free and bound flavonoids,  anthocyanins, and alkaloids and the profile of polyphenols of edible ripe pods ofProsopis alba and Prosopis nigra.  P. alba flour showed significantly higher total (sum of Free- and Bound) phenolic content and total flavonoid  compounds than P. nigra (p b 0.05) while P. nigra had higher concentrations of anthocyanins than P. alba  (p b 0.05). The P. nigra flour shows a pattern characterized by the occurrence of anthocyanins as well as 14  flavonoid glycosides, with higher chemical diversity than P. alba, which shows 8 flavonoid glycosides as relevant  constituents. The main compounds were quercetin O-glycosides and apigenin-based C-glycosides. The phenolic  composition of two South American algarrobo pod flour is presented for the first time. P. nigra pods having higher  content of anthocyanins are darker (purple) than those ofP. alba (light brown). Furthermore, the sugar-free polyphenolic extracts of P. nigra and P. alba as well as anthocyanins enriched extracts from P. nigra showed antioxidant activity. P. nigra and P. alba polyphenolic extracts showed activity against a pro-inflammatory enzyme. In  conclusion, algarrobo pods meal contained biologically active polyphenols, with a positive impact on human  health","palabras_clave":"Prosopis|Mesocarp flour|Phenolic compounds|Anthocyanin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2502,"idioma_id":4,"titulo":"New constraints on the Jurassic-Cretaceous boundary in the High Andes using high-precision U-Pb data.","resumen":"The Jurassic?Cretaceous (J?K) boundary is poorly constrained, and is the only Phanerozoic system boundary that lacks an internationally accepted reference stratigraphic section (GSSP). Precise radio-isotopic U?Pb data are unavailable for the earliest stage of the Cretaceous? the Berriasian. The age of the Jurassic?Cretaceous boundary was based on several assumptions, including the relative duration of ammonite zones, the constant spreading rates of magnetic anomalies, and the extrapolation of Rb?Sr or K?Ar isotopic data. This paper discusses a site in an Andean Basin of Western Gondwana showing the J?K boundary interval with geographically widespread nannofossil markers which are here uniquely combined with precise radiometric dates. The recent finding of a  sequence of marine black shales in the High Andes of Argentina, interbedded with ash-fall tuffs, provides important constraints on this boundary. This succession bears calcareous nannofossils and ammonites, which allow correlation with well-established Tethyan floras and faunas in the northern hemisphere. The Tithonian? Berriasian transition in the Andes was recognized on the basis of ammonite zones and nannofossil bioevents for the first time in the southern hemisphere. The new ages obtained are 137.9 ± 0.9 Ma by sensitive highresolution ion microprobe (SHRIMP), and 139.55 ± 0.09\/0.18 Ma by chemical-abrasion isotope-dilution thermal ionization mass spectrometry (TIMS) near the base of the Berriasian. These new ages can be interpreted in two different ways. The first alternative would indicate that the present geological time table is correct and the fossil levels should be late Berriasian. The second alternative is that the J?K boundary is 5 Mayounger than the recently published geological time scale. The authors support the last alternative and propose that the J?K boundary should be close to 140 Ma.","palabras_clave":"J-K BOUNDARY|NANNOFOSSILS|AMMONIOTES|U-Pb SHRIMP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2503,"idioma_id":4,"titulo":"The Gondwana connection of northern Patagonia.","resumen":"    A multidisciplinary study (U?Pb sensitive high-resolution ion microprobe geochronology, Hf and    O isotopes in zircon, Sr and Nd isotopes in whole-rocks, as well as major and trace element geochemistry)    has been carried out on granitoid samples from the area west of Valcheta, North Patagonian Massif, Argentina.    These confirm the Cambrian age of the Tardugno Granodiorite (528 ?E} 4 Ma) and the Late Permian age    of granites in the central part of the Yaminue complex (250 Ma). Together with petrological and structural    information for the area, we consider a previously suggested idea that the Cambrian and Ordovician granites    of northeastern Patagonia represent continuation of the Pampean and Famatinian orogenic belts of the Sierras    Pampeanas, respectively. Our interpretation does not support the hypothesis that Patagonia was accreted in    Late Palaeozoic times as a far-travelled terrane, originating in the Central Transantarctic Mountains, and the    arguments for and against this idea are reviewed. A parautochthonous origin is preferred with no major ocean    closure between the North Patagonian Massif and the Sierra de la Ventana fold belt.","palabras_clave":"U-Pb crystallization ages|Sm-Nd, Lu-Hf and Rb-Sr systems|Neopaleozoic-Eomesozoic magmatism|North Patagonian Massif"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2589,"idioma_id":4,"titulo":"Changes in the epipelic diatom assemblage in nutrient rich streamsdue to the variations of simultaneous stressorsJoaquín","resumen":"tBenthic diatoms are often used for assessing environmental conditions, such as water quality and habitatconditions in stream and river systems. Although laboratory experiments have shown that each diatomspecies have different levels of tolerance to different stressors, few studies have been conducted in labora-tory settings that analyze the responses of the diatom assemblage to the effects of multiple simultaneousvariables. The aim of this study was to evaluate some structural responses (such as species compositionand diversity) of the diatom assemblage on a short time scale to the effects of the simultaneous increase infour variables that are directly linked to the environmental changes affecting the Pampean streams: tur-bidity, nutrients (phosphorous and nitrogen), water velocity and temperature. To this end we conducted afive-week laboratory experiment using artificial channels where we simulated two environmental con-ditions (LOW and HIGH) employing epipelic biofilm from a mesotrophic stream. The results obtainedin the experiment show that the structure of the diatom assemblage in the epipelic biofilm is affectedby the simultaneous modification of temperature, water velocity, nutrient concentration and turbidity.These modifications in the assemblage included moderate decreases in diversity, small decreases in theproportion of species sensitive to eutrophication and saprobity, moderate increases in the IDP (PampeanDiatom Index) values and moderate changes in the percentages of the stalked growth-forms. The relativeabundance of species such as Luticola mutica, Navicula cryptocephala and Navicula lanceolata were neg-atively affected by both treatments; other species such as Planothidium lanceolatum, Caloneis bacillum,Encyonema minutum, Humidophila contenta, Luticola kotschyi, Nitzschia amphibia, Navicula veneta, Pinnu-laria subcapitata var. subcapitata were positively affected by the HIGH treatment; and Nitzschia fonticolawas positively affected by both treatments. The results suggest that, in the very short term of the bioas-say conducted, the diatom assemblage can modify its structure to respond in a sensitive manner to theabrupt changes in multiple physical?chemical variables.","palabras_clave":"Epipelic diatom assemblage|Turbidity|Nutrients|Water velocity|Temperature|Artificial channels|Argentina Pampean plain"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2592,"idioma_id":5,"titulo":"Desarrollo de la Capacidad de Memoria de Trabajo: Efectos de Interferencia Inter e Intra Dominio en Niños de edad escolar. volumen 7","resumen":"La memoria de trabajo (MT) refiere al sistema  cognitivo que se ocupa del almacenamiento temporal y procesamiento concurrente  de estímulos. Se ha propuesto que la habilidad para inhibir información  irrelevante subyace a los cambios en MT observados durante la infancia, ya que la  habilidad inhibitoria en el paradigma de doble tarea cambiaría dependiendo de que  las tareas primaria y secundaria sean de similar o diferente modalidad. El objetivo de este trabajo fue explorar el desarrollo de la MT en los  dominios verbal y visoespacial tomando en cuenta la interferencia de modalidad específica  versus no específica. Para  ello se administró a 100 niños, de entre nueve y 11 años de edad, una batería basada  en el paradigma dual que consta de tareas primarias y secundarias verbales y  viso-espaciales. Los resultados muestran menores rendimientos de la memoria  viso-espacial, mejor rendimiento sin tarea concurrente, y con tareas  concurrentes intermodales, y diferencias en el rendimiento en tareas  concurrentes interdominio verbal y espacial en los tres grupos etáreos. Estos  hallazgos ponen en duda el papel del control inhibitorio en el desarrollo de la  memoria de trabajo en la edad evaluada.","palabras_clave":"MEMORIA DE TRABAJO|DESARROLLO|INTERFERENCIA|DOMINIOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2595,"idioma_id":4,"titulo":"Lactobacillus delbrueckii subsp. bulgaricus CRL 454 cleaves allergenic peptides of b-lactoglobulin","resumen":"Whey, a cheese by-product used as a food additive, is produced worldwide at 40.7 million tons per year.b-Lactoglobulin (BLG), the main whey protein, is poorly digested and is highly allergenic. We aimed tostudy the contribution of Lactobacillus delbrueckii subsp. bulgaricus CRL 454 to BLG digestion and to analyse its ability to degrade the main allergenic sequences of this protein. Pre-hydrolysis of BLG byL. delbrueckii subsp. bulgaricus CRL 454 increases digestion of BLG assayed by an in vitro simulated gastrointestinal system. Moreover, peptides from hydrolysis of the allergenic sequences V41-K60,Y102-R124, C121-L140 and L149-I162 were found when BLG was hydrolysed by this strain. Interestingly,peptides possessing antioxidant, ACE inhibitory, antimicrobial and immuno-modulating properties werefound in BLG degraded by both the Lactobacillus strain and digestive enzymes. To conclude, pre-hydrolysis of BLG by L. delbrueckii subsp. bulgaricus CRL 454 has a positive effect on BLG digestion and coulddiminish allergenic reactions.","palabras_clave":"beta-lactoglobulin|whey|lactic acid bacteria|lactobacillus"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2600,"idioma_id":4,"titulo":"Solvent effect in keto enol tautomerism for a polymerizable beta-ketonitrile monomer. Spectroscopy and theoretical study","resumen":"The beta-ketonitrile 2-methyl-5-phenyl-3-oxo-4-pentenenitrile, a polymerizable monomer, exists in twoimportant tautomeric forms, keto and enol isomers. This compound has been studied as monomer inpolymerization reactions and the resulting polymers have been applied in fields of nanotechnology.Currently, these are being studied in nanomedicine. To understand the tautomeric equilibrium, we havestudied this compound in solution by NMR spectrometry. Correlation with DFT calculations has beencarried out in order to understand the system behavior. The results found in this work, both by experimentsand calculations, show that the enol content increases with solvent polarity","palabras_clave":"beta;-Ketonitrile|2-Methyl-5-phenyl-3-oxo-4-pentenenitrile|Tautomeric equilibria |NMR spectrometry|DFT calculations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2601,"idioma_id":4,"titulo":"Development of a LC-MS\/MS methodology for the monitoring of the antichagasic drug benznidazole in human urine","resumen":"Monitoring the drug benznidazole in biological &#64258;uids is a powerful tool for clinical diagnostic and pharmacological stdies in chagasic patients. However, research in this concern needs to be done. The accurate quantitation of this drug in complex matrices represents a highly challenging task complicated by the absence of sensitive analytical methods. It follows that sample processing strategies, preparation\/cleanup procedures, and chromatographic\/ionization\/detection parameters, were evaluated for method optimization. The summation of this work generated a rapid, selective, sensitive methodology based on reversed-phase chromatography?tandem mass spectrometry for the analysis of benznidazole in urine samples. To the best of our knowledge, this is a &#64257;rst report of a LC?MS\/MS platform employed for this application. Matrix effect was determined; a 90% of signal suppression was observed. The limits of detection and quanti&#64257;cation were 0.75 and 4.85 &#956;gL1 ; respectively. The latter allowed the method´s application to the detection of benznidazole in clinical studies and pharmacological monitoring analysis.","palabras_clave":"Benznidazole|Urine|LC-MS\/MS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2602,"idioma_id":4,"titulo":"New record of the ectoparasite insect Speiseria ambigua Kessel, 1925 (Diptera: Streblidae) of Platalina genovensium Thomas, 1928 (Chiroptera: Phyllostomidae) from Peru","resumen":"Platalina genovensium Thomas, 1928, the largest Lonchophyllinae, is a highly specialized phyllostomid bat that feeds primarily on columnar cacti and is listed as Near Threatened by the IUCN. Here we report a new record of an ectoparasite insect for Platalina, Speiseria ambigua Kessel, 1925 (Diptera: Streblidae), obtained from a bat inventory carried out in northwestern Peru. Additionally this record represents the northernmost record of S. ambigua in Peru.","palabras_clave":"BAT|ECTOPARASITE|NEOTROPICAL|RECORD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2604,"idioma_id":5,"titulo":"Sobre algunos aspectos clásico-keynesianos del modelo del Nuevo Consenso Macroecononómico","resumen":"El presente trabajo reinterpreta el modelo canónico del nuevo consenso macroeconómico (NCM) a la luz de la teoría clásico-keynesiana del valor y la distribución formalizada en tiempos relativamente recientes por Sraffa (1966[1960]). El objetivo consiste en mostrar que la política monetaria puede influir en la distribución del ingreso, y alcanzar, contrariamente a lo sostenido por los autores del NCM, efectos persistentes en los niveles de producto y empleo.","palabras_clave":"Nuevo Consenso Macroeconómico|Blanchard|tasa de interés|Teoría monetaria de la distribución"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2606,"idioma_id":4,"titulo":"EVALUATION OF THE EFFICIENCY OF STRATEGIES USED IN AN EDUCATIONAL-PREVENTIVE PROGRAMME","resumen":"One of the strategies to reach health, is to give citizens the necessary education, this implies a process in which knowledge is transfered, taking into account creativity and investigation, and allowing not only students but also teachers to recognize problems and to design strategies to contribute to its solution. Objective: To evaluate the influence of the educational-recreative-associative component on the oral hygiene and in general knowledge about bucal health.Materials and Methods:  The work has been done taking a population of 82 children (between 6 and 9 years old) from Eloy Gómez school, from Falda de Los Reartes, Córdoba. Through surveys, the degree of previous knowledge about bucal health was determined. Games, practices of bucal hygiene, visual resources and radial difusion (among others) were designed and applied, participating teachers, students, parents and the community in general. To measure acquired knowledge, surveys where daily habits and behaviours respecting bucal health were evaluated. They were adapted to their age, being previously checked and approved by specialists in this area. Results: The cuadratic chi test was applied to set a correlation among observed characteristics. The one that presented significative differences (p>0,05) was the acquisition of knowledge about health habits. The rest of the variables did not present significative differences, except for the origins of gum bleeding and day times for toothbrushing (p<0,05). Conclusion: It could be inferred that the use of different strategies develop and strengthen the knowledge about bucal health and care in children, and new teaching-learning experiences might be organizad.","palabras_clave":"EDUCATION| BUCAL HEALTH|EDUCATIONAL RECREATIVE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2607,"idioma_id":4,"titulo":"Cyclic deformation and microstructural behaviour of reduced activation ferritic martensitic steels","resumen":"The present paper presents results about cyclic behaviour and the evolution of the dislocation structure of reduced activation ferritic?martensitic steels and commercial martensitic steels AISI 410 and 420. The variation of the free dislocation density within subgrains and subgrain size was mainly analysed during the cyclic softening of EUROFER 97 steel. From the analysis of the flow stress components, the friction and back stresses, and the information of the evolution of the dislocation structure, it could be concluded that the softening of tempered martensitic steels at 20uC is produced by the contribution of the friction stress and aided later by the back stress.","palabras_clave":"RAFM Steel|Martensitic steels|LCF|Microstructure|dislocations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2608,"idioma_id":4,"titulo":"Fine mapping of LrSV2, a race&#8209;specific adult plant leaf rust  resistance gene on wheat chromosome 3BS","resumen":"Fine mapping permits the precise positioning of genes within chromosomes, prerequisite for positional cloning that will allow its rational use and the study of the underlying molecular action mechanism. Three leaf rust resistance genes were identified in the durable leaf rust resistant Argentinean wheat variety Sinvalocho MA: the seedling resistance gene Lr3 on distal 6BL and two adult plant resistance genes, LrSV1 and LrSV2, on chromosomes 2DS and 3BS, respectively. To develop a high-resolution genetic map for LrSV2, 10 markers were genotyped on 343 F2 individuals from a cross between Sinvalocho MA and Gama6. The closest co-dominant markers on both sides of the gene (3 microsatellites and 2 STMs) were analyzed on 965 additional F2s from the same cross. Microsatellite marker cfb5010 cosegregated with LrSV2 whereas flanking markers were found at 1 cM distal and at 0.3 cM proximal to the gene. SSR markers designed from the sequences of cv Chinese Spring BAC clones spanning the LrSV2 genetic interval were tested on the recombinants, allowing the identification of microsatellite swm13 at 0.15 cM distal to LrSV2. This delimited an interval of 0.45 cM around the gene flanked by the SSR markers swm13 and gwm533 at the subtelomeric end of chromosome 3BS.","palabras_clave":"WEATH|RUST|FINE MAPPING|PUCCINIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2609,"idioma_id":4,"titulo":"Hydrogenation of Tetralin Over Ir Catalysts Supported on Titania-Modified SBA-16","resumen":"A series of Ti modified SBA-16 supports and  their respective Ir-catalysts were prepared and characterized  to study the effect of support preparation method on  the dispersion of iridium and on the characteristics of Ir  surface species. Two methods of incorporation of titania  were tested: the sol gel method in order to obtain Ti as  heteroatom and incipient wetness impregnation to obtain Ti  as TiO2 (anatase phase). The results show that supports  with different Ti species and dispersion can be obtained.  The final catalyst was characterized at different preparation  stages by XRD, elemental analysis and BET. The presence  of Ti as Ti4? in the nanostructure of SBA and as TiO2  (anatase phase) was analyzed by UVVis, DRS and Raman  spectroscopy. The iridium oxidation sate upon Ti-containing  SBA-16 was studied by XPS, EDX, TEM and  XRD, arriving at the good proportion of Ir0. H2 chemisorption  and TEM characterization for Ti-SBA-16 indicated  that Ir particle size was lower than anatase\/SBA-16.  The catalyst that we synthesized had good activity measured  in tetralin hydrogenation in presence of quinoline at  mild conditions. The experimental data were quantitatively  represented by a modified Langmuir-Hinshelwood-type  rate equation. The preliminary results show these materials  as promising catalysts for HDS\/HDN reactions.","palabras_clave":"IRIDIUM-CONTAINING SBA-16 |TITANIUMMODIFIED SBA-16|HYDROGENATION|INHIBITION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2610,"idioma_id":4,"titulo":"Elemental composition of strawberry plants inoculated with the plant growth-promoting bacterium Azospirillum brasilense REC3 assessed by scanning electron microscopy and energy dispersive X-ray analysis","resumen":"The elemental composition of strawberry plants (Fragaria ananassa cv. Macarena)inoculated with the plant growth-promoting bacterium Azospirillum brasilense REC3,and non-inoculated controls, was studied using scanning electron microscopy (SEM)and energy dispersive X-ray (EDS) analysis. This allowed simultaneous semi-quantificationof different elements in a small, solid sample. Plants were inoculated andgrown hydroponically in 50% or 100% Hoagland solution, corresponding to limitedor optimum nutrient medium, respectively. Bacteria-inoculated plants increased thegrowth index 45% and 80% compared to controls when grown in 100% and 50% Hoaglandsolution, respectively. Thus, inoculation with A. brasilense REC3 in a nutrientlimitedmedium had the strongest effect in terms of increasing both shoot and rootbiomass and growth index, as already described for Azospirillum inoculated intonutrient-poor soils. SEM-EDS spectra and maps showed the elemental compositionand relative distribution of nutrients in strawberry tissues. Leaves contained C, O, N,Na, P, K, Ca and Cu, while roots also had Si and Cl. The organic fraction (C, O and N)accounted for over 96.3% of the total chemical composition; of the mineral fraction,Na had higher accumulation in both leaves and roots. Azospirillum-inoculated andcontrol plants had similar elemental quantities; however, in bacteria-inoculated roots,P was significantly increased (34.33%), which constitutes a major benefit for plantnutrition, while Cu content decreased (35.16%).","palabras_clave":"Azospirillum brasilense|strawberry|energy dispersive X-ray spectroscopy|scanning electron microscopy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2611,"idioma_id":4,"titulo":"Characterization of microstructures and age hardening of Fe1\u0001-2xAlxVx alloys","resumen":"The Fe-rich corner of the FeeAleV system has shown phase separation into disordered A2 and orderedL21 phases. In a former work we model this ordering reaction by using ab-initio thermodynamics. Theapproach is now employed to suggest the Fe12xAlxVx alloys in order to reduce the Al content byincreasing the addition of vanadium looking for a better ductility of the solid solution which can beafterwards strengthened by coherent L21 precipitates. Four alloys with compositions in the range0.08 &lt; X &lt; 0.15 were studied. The phase transition temperatures and microstructures of the alloys werecharacterized by differential scanning calorimetry (DSC) and transmission electron microscopy (TEM),respectively. The region (A2 þ L21) occurs for 0.10 &lt; X &lt; 0.15 up to maximum temperature of 720 C,higher temperatures causes the appearance of (A2 þ B2), B2 and (B2 þ L21) regions. The microstructurein the (A2 þ L21) region consists of nanosized precipitates of L21 phase in A2 matrix which morphologyevolutes with temperature and ageing time. The hardness values, measured at room temperature, for thealloys with X &lt; 0.125 and ageing temperature between 650 and 700 C are comparable to those obtainedwith other FeeAl based alloys.","palabras_clave":"Iron aluminides (based on Fe3Al)|Alloy design|Age-hardening|ab-initio calculations|Calorimetry|Electron microscopy, transmission"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2612,"idioma_id":4,"titulo":"Toxoplasma gondii and Neospora caninum infections in goat abortions from Argentina","resumen":"The aims of this study were to identify the occurrence of T. gondii and N. caninum abortions in goats from Argentina by serological, macroscopical and microscopical examination and bioassay, and to characterize the obtained isolates by molecular techniques. For this purpose, 25 caprine fetal fluids, 18 caprine fetal brains and 10 caprine placentas from 8 dairy\/meat goat farms from Argentina were analyzed. Gestational age of the aborted fetuses was determined in 18 cases. Protozoal infections were detected by at least one of the applied diagnostic techniques in 44% (11\/25) of examined fetuses; specifically, 24% (6\/25) were positive to T. gondii, 8% (2\/25) were positive to N. caninum and 12% (3\/25) were positive to both parasites. In this study IFAT titers were similarly distributed in younger and older fetuses. Macroscopical and microscopical examination of one placenta revealed chalky nodules in the fetal cotyledons and normal intercotyledonary areas, as well as necrosis and calcification of mesenchymal cells in villi. Tachyzoites were observed in peritoneal wash from 2 mice inoculated with brain and a pool of brain and placenta of two foetuses. Cell culture growth of tachyzoites was achieved from one inoculated mouse, and confirmed as T. gondii by PCR. The T. gondii isolate was identified as atypical or non canonical by nested-PCR-RFLP. This is the first study that investigated the involvement of N. caninum and T. gondii in cases of goat abortion in Argentina.","palabras_clave":"TOXOPLASMA GONDII|NEOSPORA CANINUM|GOAT|ABORTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2614,"idioma_id":4,"titulo":"Ephemeroptera from the Venezuelan Guayanas´s Uplands: Families Leptophlebiidae, Euthyplociidae and Oligoneuriidae. Zootaxa","resumen":"As a continuation of a series of papers to improve the knowledge of the Ephemeroptera fauna of the Venezuelan Guayana´s Uplands, an update of the families Leptophlebiidae, Euthyplociidae and Oligoneuriidae in the region is presented. As a result, Paramaka incognita sp. nov. is described, the female of Askola emmerichi is described for the first time, and the genera Askola, Hydrosmilodon and Leentvaaria, the subgenus Miroculis (Atroari) and the species Miroculis (M.) marauiae are recorded for the first time for Venezuela.","palabras_clave":"ASKOLA|PARAMAKA|HAGENULOPSIS|SIMOTHRAULOPSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2615,"idioma_id":4,"titulo":"Load-biased martensitic transformation strain of Ti50-Ni47-Co3 strip obtained by a twin-roll casting technique","resumen":"Mechanical properties of the Ti-47Ni-3Co (at.%) strips produced by twin-roll casting are analyzed, focusing on the maximum recoverable strain obtained by inducing the martensitic transformation under constant tensile load. The recoverable strain achieves a value close to 5.5 % for a load of &#8764; 120 MPa. The microstructure shows a typical cellular solidi&#64257;cation structure, where the austenite grains tend to a columnar array morphology with strong {100}B2 &#64257;ber texture aligned with ND (perpendicular to the strip surface). On the basis of the measured texture, the maximum B2 &#8594; B19&#8242; transformation strain was estimated at 5.6%, using a Sachs-type upper bound model, which averages the most favorable martensite variants in each grain, disregarding interactions between them. The agreement between the measured maximum recoverable strain and the model?s outcome is ascribed to special properties of Ti-Ni alloys, which allow them to overcome incompatibilities in shape changes of transforming grains in this particular polycrystalline environment.","palabras_clave":"Ti-Ni alloys|TWIN ROLL CASTING|MECHANICAL PROPERTIES|SHAPE MEMORY ALLOYS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2616,"idioma_id":4,"titulo":"Search for supersymmetry in events with large missing transverse momentum, jets, and at least one tau lepton in 20 fb&#8722;1 of s&#8730;= 8 TeV proton-proton collision data with the ATLAS detector","resumen":"A search for supersymmetry (SUSY) in events with large missing   transverse momentum, jets, at least one hadronically decaying tau lepton   and zero or one additional light leptons (electron\/muon), has been   performed using 20.3fb&#8722;1 of proton-proton collision data at  s&#8730;    = 8 TeV recorded with the ATLAS detector at the Large Hadron Collider.   No excess above the Standard Model background expectation is observed in   the various signal regions and 95% confidence level upper limits on the   visible cross section for new phenomena are set. The results of the   analysis are interpreted in several SUSY scenarios, significantly   extending previous limits obtained in the same final states. In the   framework of minimal gauge-mediated SUSY breaking models, values of the   SUSY breaking scale &#923; below 63 TeV are excluded, independently of tan &#946;. Exclusion limits are also derived for an mSUGRA\/CMSSM model, in both the R-parity-conserving and R-parity-violating   case. A further interpretation is presented in a framework of natural   gauge mediation, in which the gluino is assumed to be the only light   coloured sparticle and gluino masses below 1090 GeV are excluded.","palabras_clave":"ATLAS|proton-proton collision|supersymmetry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2617,"idioma_id":4,"titulo":"Reply to Luzzatto et al. (2014): ?Comment on ?Genetic evidence and new morphometric data as essential tools to identify the Patagonian seahorse Hippocampus patagonicus (Pisces, Syngnathidae), González et al. (2014)??","resumen":"The aim of the contribution of González et al. (2014) was to improve the original  description and validate the taxonomic status of the Patagonian seahorse Hippocampus  patagonicus Piacentino & Luzzatto 2004. To do so, the authors analysed morphological  and genetic characteristics of seahorses of San Antonio Bay, Argentina. Concerning  both issues, the information presented lacks validity and originality.","palabras_clave":"HIPPOCAMPUS PATAGONICUS|ARGENTINA|GENETICS|PHYLOGENETICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2618,"idioma_id":4,"titulo":"NF-&#954;B Transcriptional Activity is Modulated by FK506-binding Proteins FKBP51 and FKBP52: A Role for Peptidyl-prolyl Isomerase Activity","resumen":"Hsp90 binding immunophilins FKBP51 and FKBP52 modulate steroid receptor trafficking and hormone-dependent biological responses. With the purpose to expand this model to other nuclear factors that are also subject to nuclear-cytoplasmic shuttling, we analyzed whether these immunophilins modulate NF-&#954;B signaling. It is demonstrated that FKBP51 impairs both the nuclear translocation rate of NF-&#954;B and its transcriptional activity. The inhibitory action of FKBP51 requires neither the peptidylprolyl-isomerase activity of the immunophilin nor its association with Hsp90. The TPR domain of FKBP51 is essential. On the other hand, FKBP52 favors the nuclear retention time of RelA, its association to a DNA consensus binding sequence, and NF-&#954;B transcriptional activity, the latter effect being strongly dependent on the peptidylprolyl-isomerase activity and also on the TPR domain of FKBP52, but its interaction with Hsp90 is not required. In unstimulated cells, FKBP51 forms endogenous complexes with cytoplasmic RelA. Upon cell stimulation with phorbol ester, the NF-&#954;B soluble complex exchanges FKBP51 for FKBP52, and the NF-&#954;B biological effect is triggered. Importantly, FKBP52 is functionally recruited to the promoter region of NF-&#954;B target genes, whereas FKBP51 is released. Competition assays demonstrated that both immunophilins antagonize one another, and binding assays with purified proteins suggest that the association of RelA and immunophilins could be direct. These observations suggest that the biological action of NF-&#954;B in different cell types could be positively regulated by a high FKBP52\/FKBP51 expression ratio by favoring NF-&#954;B nuclear retention, recruitment to the promoter regions of target genes, and transcriptional activity.","palabras_clave":"NF-kB|FK506-binding protein of 51-kDa (FKBP51)|RelA|FK506-binding protein of 52-kDa (FKBP52)|Peptidyl-prolyl isomerase (PPIase)|Chromatin Immunoprecipitation (ChIP)|90-kDa Heat-shock protein (Hsp90)|Protein trafficking|Immunophilin exchange"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2619,"idioma_id":5,"titulo":"Los Términos de Intercambio y su impacto en la exportación de limón de  Tucumán. Argentina. 2014.","resumen":"Los  términos  de  intercambio  (TI)  se  definen como la razón entre el precio de las exportaciones de un país (PX) y el precio de sus importaciones (PM). Esta relación, refleja la capacidad de com-pra que tienen los productos domésticos vendidos en el extranjero y por lo tanto es uno de los deter-minantes del ingreso disponible de la economía y de las decisiones de ahorro y consumo de los ho-gares, variables cruciales en los análisis de política económica. Desde el punto de vista estrictamente contable, una ganancia de términos de intercambio refleja una mejora en el poder de compra interna-cional de nuestros bienes y servicios exportables. Como tal, este aumento no forma parte compo-nente del Producto Interno Bruto (PBI), sino del Ingreso Interno Bruto de la economía, constitu-yéndose de esta manera en una limitante del PBI como medida de desarrollo, razón por la cual se ha cuestionado la utilización de los mismos como indicadorindirecto del bienestar social de un país. Dada la importancia que tienen los TI para medir las potencialidades económicas (o no) de una eco-nomía, puede resultar atractivo conocer o estimar un TI propio para Tucumán. Los términos de in-tercambio constituyeron durante la historia econó-mica argentina una variable de suma relevancia. Argentina se ha beneficiado desde 2003 a la fecha de una mejora en sus TI, especialmente debido a la mejora de los precios de sus productos exportados. El trabajo realizado consistió en un análisis basado en los datos obtenidos sobre las exportaciones del limón en la Provincia de Tucumán. Argentina es actualmente el primer productor mundial de limo-nes, donde el 90% de esa producción tiene como origen la provincia de Tucumán. Cabe destacar que el limón es un producto de exportación, tan-to en su etapa primaria (obtención de fruta fresca) como en su fase industrial (elaboración de jugos concentrados y subproductos como aceite esencial y cáscara deshidratada). El objetivo del trabajo es determinar el aporte de los términos de intercam-bio y su impacto en la exportación de limón de Tu-cumán","palabras_clave":"Termino de Intercambio|Limón|Exportación|Tucumán"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2622,"idioma_id":4,"titulo":"Examining the impact of bone pathology on type I Gaucher's disease","resumen":"Gaucher disease (GD) is an autosomal recessively inherited lysosomal disorder caused by mutations in GBA gene leading to deficient activity of the lysosomal enzyme acid &#946;-glucocerebrosidase. Phenotipically, 3 different forms can be distinguished, being type I Gaucher disease the most frequent one, and characterized by the absence of involvement of the central nervous system. Affected organs are the spleen, liver, bone marrow and bone and, in severe cases, also the lung and kidney. Bone manifestations include bone pain, bone crises, osteopenia, osteoporosis, avascular necrosis and pathological fractures. Nowadays, skeletal alterations are the major cause of morbidity for patients, and a major concern for physicians who treat them, because of variable grade of response and refractoriness of bone pathology to treatment. Pathological mechanisms of bone alterations in GD are still poorly understood. Advances are being achieved in the knowledge of cellular and molecular mechanisms; by means of handle these studies in the field of osteoimmunology. GD as well as other lysosomal disorders is associated to a chronic stimulation of immune system, specially the innate arm. Cellular alteration produces a proinflammatory milieu leading to enhancement of the activity of osteoclasts, the main degradative\/resorptive cell of bone. This article focuses on the details of bone alterations, effect of therapies on skeletal pathology, and our current state of knowledge of the complex pathophisiology of this orphan disease","palabras_clave":"GAUCHER DISEASE|BONE PATHOLOGY|GLUCOCEREBROSIDASE|OSTEOIMMUNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2673,"idioma_id":5,"titulo":"'Presentación del número 6 de ZAMA'","resumen":"Presentación editorial (en mi carácter de secretario de redacción) del número 7 de ZAMA, la revista del Instituto de Literatura Hispanoamericana de la Facultad de Filosofía y Letras de la UBA. En el texto, que celebra con este número el 80 aniversario del Instituto, se alude a la pregunta ¿qué es Latinoamérica? Decir Latinoamérica en nuestras literaturas sería proponer una política de la lenguay una paradójica heterogeneidad proliferante que todavía sueña la unidad. Esamisma unidad que se invoca desde todas las batallas de la independencia, desdela emancipación a las formas diversas del latinoamericanismo, también como unadefensa ante una amenaza que adquiere diversos rostros y dimensiones, la amenazaque se denomina invasora, colonialista, neocolonialista, imperialista, hegemonizante,dominante, centralizadora, globalizadora. La religación, como lo enseñó Susana Zanetti en su estudio ineludible sobre el período de la modernidad (1880-1916), consiste en diseñar el continuo tramado de textos, autores y lecturas que configuran el proceso literario latinoamericano.","palabras_clave":"Latinoamérica|Religación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2688,"idioma_id":4,"titulo":"Switched control to human-robot bilateral interaction for guiding people","resumen":"This paper presents a switched control strategy to interpret and design a human-robot bilateral interaction when a human follows a non-holonomic mobile robot at a desired distance while the robot is already following a known path. Furthermore, it proposes and experimentally validates a model that mathematically describes the human behavior when performing the specific task of tracking a mobile robot. This model is useful for the purposes of the control system design and its associated stability analysis. A switched system is proposed to model the complete human-robot behavior. The switching strategy  is based on the human-robot relative position and on the human intention to follow the robot. Control errors are defined in terms of human to robot and robot to path instantaneous distances. Stability analyses for the individual controllers, as well as for the complete switching system, are provided by considering Lyapunov theory. Real human-robot interaction experiments show the good performance of the proposed control strategy.","palabras_clave":"Human-robot interaction|Bilateral interaction|Mobile robots|Lyapunov stability"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2696,"idioma_id":4,"titulo":"Use of Tilted Implants in Prosthetic Rehabilitation","resumen":"ABSTRACT: Biomechanical measurements show that tilted implants, when part of a prosthetic support, avoid theuse of distal cantilever units. This study included 20 women (78%) and 12 men (22%), aged over 50 years old (89%), with atotal of 156 implants. A delayed occlusal loading protocol was used and the average distal implant length and diameter were10 mm and 4mm respectively. Patients were followed up for 2 to 5 years after prosthesis connection. The aims of this studyare to analyze the use of tilted implants in prosthetic rehabilitation of maxillae to reduce cantilevers length, and to study the biomechanical implications of implant-bone interface.","palabras_clave":"TILTED IMPLANTS|CANTILEVER|EDENTULOUS MAXILLAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2698,"idioma_id":5,"titulo":"Influencia de la estructura muscular y del sitio de toma de muestras sobre parametros que evaluan la calidad de carne porcina","resumen":"El músculo bíceps femoral de cerdo (BF) presenta cuatro compartimentos neuromusculares (CNMs), con variacionessignificativas en el área relativa (AR), área absoluta (AA) de los tipos de fibras e índice de difusión capilar (IDC). Estasvariaciones deben considerarse al estudiar las relaciones entre estructura muscular y parámetros que evalúan la24 calidad de carne. La hipótesis planteada fue que los parámetros estudiados que evalúan calidad de carne: pH ,resistencia al corte (W B), índice de rojo (a ) e índice de amarillo (b ) varían significativamente entre los CNMs, de * *acuerdo con sus características estructurales y bioquímicas. Muestras de los CNMs (BR1, BR2, BR3, BR4) de 10 BF,24 fueron utilizadas para medir pH (peachímetro Testo 230), a y b* (colorímetro Minolta CR-300) y W B, luego de baño * en agua 50 minutos a 75°C (Instron 4442). En los CNMs los tipos de fibras I, IIA, IIX y IIB, IDC y áreas de conectivose determinaron inmunohistoquímicamente. Los análisis estadísticos se realizaron mediante pruebas paramétricas deANOVA 24 (pBR3=BR2=BR1, a*: BR4>BR1=BR2=BR3, W B: BR4<BR3, BR2,BR1, siendo BR1=BR2 y BR3=BR1. El menor valor de pH24 en BR4 coincidió con el incremento del AA de las fibrasI, y la disminución del AA de las IIB. Los valores de a*, mostraron una asociación positiva con el AR y AA de las fibrasI y negativa con el AA y AR de IIB; W B disminuyó en BR4, correspondiendo con disminución del AR y AA de IIB.Encont s 24 ramos una correlación negativa (r = -0,316) entre pH y W B. Estructuralmente (AA, AR e IDC), el BF seorganiza en CNMs oxidativos (BR3 y BR4) y glicolíticos (BR1 y BR2). Es importante conocer la existencia de los CNMsy conocer con exactitud los sitios de toma de muestras para evaluar consistentemente los parámetros que miden lacalidad de carne.","palabras_clave":"biceps femoral del cerdo|compartimientos neuromusculares|fibra muscular|calidad de carne"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2699,"idioma_id":4,"titulo":"Understanding recognition and self-assembly in biology using the chemist´s toolbox. Insights into medicinal chemistry","resumen":"Abstract:  Medicinal chemistry is intimately connected with basic science such as organic synthesis, chemical biology and  biophysical chemistry among other disciplines. The reason of such connections is due to the power of organic synthesis to  provide designed molecules; chemical biology to give tools to discover biological and\/or pathological pathways and biophysical  chemistry which provides the techniques to characterize and the theoretical background to understand molecular  behaviour. The present review provides some selective examples of these research areas. Initially, template dsDNA organic  synthesis and the spatio-temporal control of transcription are presenting following by the supramolecular entities  used in drug delivery, such as liposomes and liquid crystal among others. Finally, peptides and protein self-assembly is  connected with biomaterials and as an important event in the balance between health and disease. The final aim of the present  review is to show the power of chemical tools not only for the synthesis of new molecules but also to improve our  understanding of recognition and self-assembly in the biological context.","palabras_clave":"biomimetic|supramolecular systems|molecular triggers|protein unfolding"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2700,"idioma_id":4,"titulo":"MILK IMPROVED THE METABOLIC SYNDROME IN OBESE &#946; RATS","resumen":"    The response of adult spontaneously obese rats  from the IIMb\/Beta strain fed a high calcium skimmed milk diet (MHCa); high  calcium from carbonate (HCa) and a normal AIN 93 diet during 45 days was  evaluated. Body weight, food intake and fecal fat excretion were measured.    At the end of the experiment rats were  euthanized, abdominal fat pads and livers were excised and weighed. Blood and  liver triacylglycerols, total cholesterol and fractions were quantified.    Body weight increase and abdominal fat pads in  the MHCa group were significantly lower than in the other two. Plasma triacylglycerols,  total and LDL-cholesterol were diminished in the MHCa group. Fecal lipid  excretion was increased in the adult MHCa group.    Total liver lipids and triacylglycerols showed a  significant diminution in the MHCa group.    These results suggest that calcium and other  bioactive compounds from milk, most probably present in whey fraction, and not  calcium carbonate exerted an \u201Canti-obesity\u201D effect on these rats.      ","palabras_clave":"milk|calcium|spontaneously obese rats"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2701,"idioma_id":4,"titulo":"Seed mass, germination and seedling traits for some central Argentinian cacti","resumen":"Seed size is one of the most important traits in the regenerative phase of a plant?s life cycle; however, for cactus species the relationship of seed size and germination characteristics and seedling traits is still unclear. We studied the relationship between seed mass and germination and seedling characteristics in 17 cactus species from central Argentina belonging to different genera and life forms. We measured seed mass, total seed germination, light requirements for germination, and mean time to germination for 17 cacti species; in addition, we recorded seedling size and shape in 15 species. To test light requirements we performed germination experiments under laboratory conditions at 25\/15 &#8304;C (day\/night temperatures) and under light or dark conditions. We also calculated seedling volume by measuring seedling height and width. A shape index was obtained by dividing height by width (a value of 1 indicates ?globose? seedlings, whereas as this value increases, seedlings become ?columnar?). We found no significant relationship between seed mass and any of the germination characteristics considered. However, species with heavier seeds produced bigger seedlings, which were more cylindrical. Adult growth was not totally determinant of seedling ?growth form?, because some species that had globose seedlings were columnar at the adult stage.","palabras_clave":"cactaceae|peso semilla|plantula|germinación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2702,"idioma_id":5,"titulo":"Variabilidad entre poblaciones silvestres de Baccharis crispa Spreng. de la Provincia de Córdoba, Argentina","resumen":"      Entre las  plantas medicinales de Argentina registradas en la Farmacopea, se encuentra la  especie Baccharis crispa Spreng., ?carqueja?. Es un subarbusto rizomatoso,  dioico, con ramas provistas de tres alas, de 2 a 6 mm de ancho. Según el Índice  de Priori dad de Conservación (elaborado para el Valle de Paravachasca de la  Provincia de Córdoba), la carqueja se encuentra tercera en orden de importancia  como prioritaria para su conservación. De manera general, la conservación  abarca la reservación y la utilización sostenible de los recursos genéticos,  protegiendo la variabilidad, esencial para su mantenimiento. El objetivo del  presente trabajo fue determinar la existencia de variabilidad, a partir de  datos de evaluaciones morfológicas, químicas y edafológicas, entre poblaciones silvestres  de Baccharis crispa Spreng. de la Provincia de Córdoba, Argentina. En cuanto al  estudio de la variación entre las poblaciones, se comprobó la existencia de  variabilidad entre ellas y se determinaron las variables que permiten la  diferenciación entre las poblaciones. Se encontró que las tres series de  variables estudiadas tuvieron un importante grado de consenso para discriminar  entre las cuatro poblaciones evaluadas.       en la Farmacopea, se encuentra la especie     Baccharis crispa     Spreng.,     ?carqueja?. Es un subarbusto rizomatoso, dioico, con ramas provis    -    tas de tres alas, de 2 a 6 mm de ancho. Según el Índice de Priori    -    dad de Conservación (elaborado para el Valle de Paravachasca de     la Provincia de Córdoba), la carqueja se encuentra tercera en orden     de importancia como prioritaria para su conservación. De manera     general, la conservación abarca la preservación y la utilización soste    -    nible de los recursos genéticos, protegiendo la variabilidad, esencial     para su mantenimiento. El objetivo del presente trabajo fue deter    -    minar la existencia de variabilidad, a partir de datos de evaluaciones     morfológicas, químicas y edafológicas, entre poblaciones silvestres de     Baccharis crispa     Spreng. de la Provincia de Córdoba, Argentina. En     cuanto al estudio de la variación entre las poblaciones, se comprobó     la existencia de variabilidad entre ellas y se determinaron las variables     que permiten la diferenciación entre las poblaciones. Se encontró que     las tres series de variables estudiadas tuvieron un importante gra     Resumen.     Entre las plantas medicinales de Argentina registradas     en la Farmacopea, se encuentra la especie     Baccharis crispa     Spreng.,     ?carqueja?. Es un subarbusto rizomatoso, dioico, con ramas provis    -    tas de tres alas, de 2 a 6 mm de ancho. Según el Índice de Priori    -    dad de Conservación (elaborado para el Valle de Paravachasca de     la Provincia de Córdoba), la carqueja se encuentra tercera en orden     de importancia como prioritaria para su conservación. De manera     general, la conservación abarca la preservación y la utilización soste    -    nible de los recursos genéticos, protegiendo la variabilidad, esencial     para su mantenimiento. El objetivo del presente trabajo fue deter    -    minar la existencia de variabilidad, a partir de datos de evaluaciones     morfológicas, químicas y edafológicas, entre poblaciones silvestres de     Baccharis crispa     Spreng. de la Provincia de Córdoba, Argentina. En     cuanto al estudio de la variación entre las poblaciones, se comprobó     la existencia de variabilidad entre ellas y se determinaron las variables     que permiten la diferenciación entre las poblaciones. Se encontró que     las tres series de variables estudiadas tuvieron un importante grado     de consenso para discriminar entre las cuatro poblaciones evaluadas.","palabras_clave":"Baccharis crispa Spreng|poblaciones silvestres|variabilidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2703,"idioma_id":4,"titulo":"Model for micro hardness Vickers prediction applied to SnO2 and TiO2 in the normal and high pressure phases","resumen":"The Vickers microhardness of TiO2 is calculated using elastic properties obtained by first principles calculations combined withDiscrete Elements Method (DEM).The calculation is carried out in rutile and cotunnite phases. It was found that rutile phase, has amicrohardness of 8.6 GPa and 12.8 GPa for the failure and fracture modes in agreement with experimental results range. Incotunnite phase the hardness for failure and fracture mode are 24.1 and 24.4 GPa, close to 26 GPa, applying Simunek model. Togive insight to this methodology, the calculation is extended to SnO2 in the normal phase. The microhardness value obtained in thefailure mode is 2.67 GPa. The method developed here, to obtain the Vickers microhardness, could be applied to a systematic studyof tailoring materials. Since hardness is related to elastic shear properties, our results can be used as an assessment of the materialproperties as solid lubricating at first order.","palabras_clave":"Elastic constants|Ceramics|Microhardness Vickers|Model"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2704,"idioma_id":4,"titulo":"Heterogeneous photocatalytic discoloration\/degradation of Rhodamine B with H2O2 and spinel copper ferrites magnetic nanoparticles","resumen":"The discoloration\/degradation  of the artificial dye Rhodamine B (RhB) was investigated using Advanced  Oxidation Technologies. Aqueous solutions of RhB containing spinel copper  ferrites (CuFe2O4) as heterogeneous catalyst were exposed  to UV irradiation\/hydrogen peroxide. Under these experimental conditions the  discoloration\/degradation of RhB is strongly promoted by copper ferrites used,  reaching 95 % discoloration of the dye in 10 minutes and 97 % degradation in 200  minutes. The influence of the catalyst amount, H2O2  concentration, light source and UV light intensity were studied. An optimum  concentration of H2O2 and catalyst dosage was found for  the RhB degradation reaction. Catalyst had high magnetic sensitivity under an  external magnetic field, which allowed its magnetic separation from water  avoiding secondary pollution processes, and its recycle. A markedly synergistic  effect of spinel copper ferrite and UV light irradiation is observed for the  RhB discoloration\/ degradation with H2O2 as a green  oxidant.","palabras_clave":"advanced oxidation processes|magnetic nanoparticle|dye  discoloration|Photocatalytic activity|copper ferrite"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2705,"idioma_id":5,"titulo":"Clave para la identificación de especies en la familia Diatrypaceae (Xylariales, Ascomycota).","resumen":"El presente trabajo brinda una clave para la identificación de las especies y\/o complejo de especies, octosporados de la familia Diatrypaceae sobre la base de caracteres morfológicos. Adicionalmente se propone dos nuevos sinónimos para Diatrype chilensis Henn y&nbsp; Eutypella murrayae Syd.","palabras_clave":"DIATRYPE|EUTYPA|EUTYPELLA|PERONEUTYPA|TAXONOMÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2706,"idioma_id":4,"titulo":"Depth of maximum of air-shower profiles at the Pierre Auger Observatory . I. Measurements at energies above 10^17.8 eV","resumen":"We report a study of the distributions of the depth of maximum, Xmax, of extensive air-shower profiles with energies above 1017.8 eV as observed with the fluorescence telescopes of the Pierre Auger Observatory. The analysis method for selecting a data sample with minimal sampling bias is described in detail as well as the experimental cross-checks and systematic uncertainties. Furthermore, we discuss the detector acceptance and the resolution of the Xmax measurement and provide parametrizations thereof as a function of energy. The energy dependence of the mean and standard deviation of the Xmax distributions arecompared to air-shower simulations for different nuclear primaries and interpreted in terms of the mean and variance of the logarithmic mass distribution at the top of the atmosphere.","palabras_clave":"cosmic ray"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2707,"idioma_id":4,"titulo":". Phylogenetic relationships among populations of the Nacobbus aberrans (Nematoda, Pratylenchidae) complex reveal the existence of cryptic species","resumen":"No","palabras_clave":"CRYPTIC SPECIES|D2-D3 EXPANSION SEGMENTS|FALSE ROOT-KNOT NEMATODE|ITS REGION|NACOBBUS|PLANT-PARASITIC NEMATODE."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2708,"idioma_id":4,"titulo":"Supported Rh nanoparticles on  CaO-SiO2 bynary systems for the reforming of methane by carbon dioxide in  membrane reactors","resumen":"A set of Rh catalysts supported on  binary CaO-SiO2 system with different CaO content were prepared.  The textural and structural properties, Rh particle size,  and catalytic performance in the dry reforming of methane reaction were investigated.   The Rh nanoparticles and nanocrystalline structures in the reduced catalysts were characterized through HRTEM and CO chemisorption.  EDX mapping showed that CaO is uniformly distributed on SiO2 and no segregation is detected between them. Rh nanoparticles of about 1-2.6 nm were observed. These particles sizes indicate that Rh is well dispersed on the catalyst surface and that no agglomeration exists.   The incorporation of the promoter (CaO) to the silica support induces an increase in the metal dispersion, however the Rh dispersion decreased when the CaO loading is increased.    For the high CaO load solids, a high stability was observed after 80 hours on stream for the dry reforming of methane. In addition, the solid with 27%  CaO presented the higher methane reaction rate. As a consequence, this solid was selected for its application in a membrane reactor under different conditions.   The increase of methane conversion with reaction pressure at high sweep gas flow rate indicates that the separation efficiency of the Pd membrane is sufficiently high to dominate the performance of Pd membrane reactors under those conditions.","palabras_clave":"METHANE REFORMING|Rh|CaO-SiO2 BINARY SUPPORT|HYDROGEN PRODUCTION|MEMBRANE REACTOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2711,"idioma_id":4,"titulo":"Physicochemical parameters and sensory properties of honeys from Buenos Aires region","resumen":"The physicochemical parameters (moisture, hydroxymethyl furfural, colour, electrical conductivity, freeacidity, glucose, fructose and sucrose) and the sensory properties(aroma, taste, appeareance, texture)were determined in honeys from apiaries of the agricultural, hills and meadow zones of the south eastregion of Buenos Aires province (Argentina). The analysis of variance showed significant differencesamong zones in the mean value of hydroximethyl furfural, colour, electrical conductivity and sucrosecontent. The principal component analysis explained the 70% of the variance among samples with thefirst two principal components in both cases. The cluster analysis and linear discriminant analysisshowed that samples were grouped in relation to the sampling region coinciding with the results ofthe principal component analysis. Results suggest that could be possible to classify honeys accordingto the geographic origin based on the physicochemical parameters; however, the sensory properties werenot good predictors.","palabras_clave":"Multifloral honey|Chemical traceabilty|Multivariate analysis|Geographic origin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2773,"idioma_id":5,"titulo":"Seguimiento de la Cooperación Sur-Sur (octubre de 2013 a abril de 2014)","resumen":"A medida que se acerca el desenlace de las negociaciones orientadas a la adopción de la futura Agenda de Desarrollo Post-2015, la III Conferencia sobre el Financiamiento del Desarrollo y la COP 21 de París, los debates en el área de la cooperación internacional en general -y la Cooperación Sur-Sur no es la excepción- se ven crecientemente inmersos en esos temas, que han desplazado ya a las prioridades y asuntos de debate tradicionales.Los 60 años transcurridos desde la Conferencia Afroasiática de Bandung, origen de la Cooperación Sur-Sur (que hemos celebrado durante el período que analizamos) sirven como recordatorio de la importancia de coordinar posiciones frente a procesos internacionales en los que las posibilidades de éxito aislado son nulas.","palabras_clave":"COOPERACIÓN SUR-SUR|AMÉRICA|ÁFRICA|AGENDA POST-2015"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2774,"idioma_id":5,"titulo":"Condiciones Agrometeorológicas de la Campaña 2014-2015 en la Provincia de Tucumán y Áreas de influencia","resumen":"Condiciones Agrometeorológicas de la Campaña 2014-2015 en la Provincia de Tucumán y Áreas de influencia.","palabras_clave":"SOJA|AGROMETEOROLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2775,"idioma_id":4,"titulo":"Model potentials in liquid water ionization by fast electron impact","resumen":"We study the ionization of water molecules in liquid phase by fast electron impact.We use our previous first-order model within an independent electron approximation that allowsthe reduction of the multielectronic problem into a monoelectronic one. The initial molecularstates of the liquid water are represented in a realistic way through a Wannier orbital formalism.We complete our previous study by taking into account approximately the influence of thedifferential cross sections for the most external orbital 1B1 and compare them with other results. ","palabras_clave":"water|liquid|ionization|electrons"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2778,"idioma_id":4,"titulo":"Rhizoremediation of phenol and chromium by the synergistic combination of a native bacterial strain and Brassica napus hairy roots","resumen":"A bacterial strain resistant to phenol and Cr (VI) was isolated from an industrial polluted soil of Córdoba  province (Argentina), which was identified as Pantoea sp. FC 1. This microorganism was able to use  phenol as sole carbon source. In addition it was capable of reducing Cr (VI) to Cr (III) in mineral and  nutrient media. The isolated strain exhibited some properties as plant-growth promoting bacterium  (PGPB), such as production of Indole Acetic Acid (IAA) and synthesis of siderophores, as well as being  capable of solubilizing inorganic phosphates. A rhizoremediation system using the associationPantoea  sp. FC 1-Brassica napushairy roots (HRs) was tested for phenol and Cr (VI) removal in a hydroponic  system. Microbial inoculation improved both phenol removal and chromium accumulation efficiency by  HRs, showing a significant increase in Cr (III) accumulation compared to non-inoculated HRs, exceeding  1000 mg kg  1  . Cr (III) was detected in HR biomass and supernatants, suggesting a possible Cr (VI)  reducing activity ofB. napusHRs. Basic studies in plant model systems, such as HRs, provide additional  useful information that could facilitate the transition of this technology into plants suitable for practical  rhizoremediation applications","palabras_clave":"PHENOL|CHROMIUM|RHIZOREMEDIATION|BIOREMEDIATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2779,"idioma_id":4,"titulo":"CLINICAL AND MOLECULAR STUDIES RELATIVE TO BONE METABOLISM IN PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA","resumen":"Patients with congenital adrenal hyperplasia  (CAH) due to 21-hydroxylase deficiency need glucocorticoid  (GC) therapy, which alters bone mineral metabolism.  We analyze clinical and biochemical parameters  and different polymorphisms of candidate genes associated  with bone mineral density (BMD) in CAH patients.  The CAH patients treated with GC and healthy controls  were studied. Anthropometric parameters, biochemical  markers of bone turnover, and BMD were evaluated.  Polymerase chain reaction technique was used to genotype  different candidate genes. The 192-192 genotype frequency  ( IGF-I ) was lower in poorly controlled patients  than that from controls. In CAH patients, FF genotype  (vitamin D receptor, VDR ) correlated with lower lumbar  spine BMD and there was a significant association  between the 0-0 genotype ( IGF-I ) and high values of  &#946; -CrossLaps and a low total BMD. This study contributes  to understanding of the association of genetic determinants  of BMD with the variable response to GC treatment  in CAH patients and demonstrates the usefulness of  these genetic polymorphisms.","palabras_clave":"bone mineral density|congenital adrenal hyperplasia|Beta-CrossLaps|IGF-I genotypes|VDR polymorphisms"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2780,"idioma_id":4,"titulo":"Antifungal susceptibility of Malassezia furfur, Malassezia sympodialis and Malassezia globosa to azole drugs and amphotericin B evaluated by a broth microdilution method","resumen":"We studied the in vitro activity of fluconazole (FCZ), ketoconazole (KTZ), miconazole (MCZ), voriconazole (VCZ), itraconazole (ITZ) and amphotericin B (AMB) against the three major pathogenic Malassezia species, M. globosa, M. sympodialis, andM. furfur. Antifungal susceptibilities were determined using the broth microdilution method in accordance with Clinical and Laboratory Standards Institute reference document M27-A3. To support lipid-dependent yeast development, glucose, peptone, ox bile,malt extract, glycerol, and Tween supplements were added to Roswell Park Memorial Institute RPMI 1640 medium. The supplemented medium allowed good growth of all three species studied. The minimal inhibitory concentrations (MICs) were recorded after 72 h of incubation at 32oC. The three species showed different susceptibility profiles for the drugs tested. Malassezia sympodialis was the most susceptible and M. furfur the least susceptible species. KTZ, ITZ, and VCZ were the most active drugs, showing low variability among isolates of the same species. FCZ, MCZ, and AMB showed high MICs and wide MIC ranges. Differences observed emphasize the need to accurately identify and evaluate antifungal susceptibility of Malassezia species. Further investigations and collaborative studies are essential for correlating in vitro results with clinical outcomes since the existing limited data do not allow definitive conclusions.","palabras_clave":"MALASSEZIA|SUSCEPTIBILITY|BROTH MICRODILUTION| AZOLE DRUG|AMPHOTERICIN B"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2781,"idioma_id":4,"titulo":"Depth of Maximum of Air-Shower Profiles at the Auger Observatory: Measurements at Energies above $10^{17.8}$ eV","resumen":"We report a study of the distributions of the depth of maximum, Xmax, of extensive air-shower profileswith energies above 1017.8 eV as observed with the fluorescence telescopes of the Pierre AugerObservatory. The analysis method for selecting a data sample with minimal sampling bias is describedin detail as well as the experimental cross-checks and systematic uncertainties. Furthermore, we discuss thedetector acceptance and the resolution of the Xmax measurement and provide parametrizations thereof as afunction of energy. The energy dependence of the mean and standard deviation of the Xmax distributions arecompared to air-shower simulations for different nuclear primaries and interpreted in terms of the mean andvariance of the logarithmic mass distribution at the top of the atmosphere.","palabras_clave":"COSMIC RAYS|OBSERVATORY PIERRE AUGER|AIR-SHOWER PROFILES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2782,"idioma_id":4,"titulo":"`Depths of Maximum of Air-Shower Profiles at the Pierre Auger Observatory: Composition Implications","resumen":"Using the data taken at the Pierre Auger Observatory between December 2004 and December 2012, we have examined the implications of the distributions of depths of atmospheric shower maximum (Xmax), using a hybrid technique, for composition and hadronic interaction models. We do this by fitting the distributions with predictions from a variety of hadronic interaction models for variations in the composition of the primary cosmic rays and examining the quality of the fit. Regardless of what interaction model is assumed, we find that our data are not well described by a mix of protons and iron nuclei over most of the energy range. Acceptable fits can be obtained when intermediate masses are included, and when this is done consistent results for the proton and iron-nuclei contributions can be found using the available models. We observe a strong energy dependence of the resulting proton fractions, and find no support from any of the models for a significant contribution from iron nuclei. However, we also observe a significant disagreement between the models with respect to the relative contributions of the intermediate components.","palabras_clave":"COSMIC RAYS|PIERRE AUGER OBSERVATORY|DEPTH OF MAXIMUM OF AIR SHOWER|CHEMICAL COMPOSITION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2783,"idioma_id":4,"titulo":"Metabolic regulation of phytoplasma malic enzyme and phosphotransacetylase supports the use of malate as an energy source in these plant pathogens","resumen":"Phytoplasmas (?Candidatus Phytoplasma?) are insect-vectored plant pathogens. The genomes of these bacteria are small with limited metabolic capacities making them dependent on their plant and insect hosts for survival. In contrast to mycoplasmas and other relatives in the class Mollicutes, phytoplasmas encode genes for malate transporters and malic enzyme (ME) for conversion of malate into pyruvate. It was hypothesized that malate is probably a major energy source for phytoplasmas as these bacteria are limited in the uptake and processing of carbohydrates. In this study, we investigated the metabolic capabilities of ?Candidatus (Ca.)phytoplasma? aster yellows witches?-broom (AYWB) malic enzyme (ME). We found that AYWBME has malate oxidative decarboxylation activity, being able to convert malate to pyruvate and  CO2 with the reduction of either NAD or NADP, and displays distinctive kinetic mechanisms depending on the relative concentration of the substrates. AYWB-ME activity was strictly modulated by the ATP\/ADP ratio, a feature which has not been found in other ME isoforms characterized to date. In addition, we found that the ?Ca. Phytoplasma? AYWB PduL-like enzyme (AYWB-PduL) harbours phosphotransacetylase activity, being able to convert acetyl-CoA to acetyl phosphate downstream of pyruvate. ATP also inhibited AYWB-PduL activity, as with AYWB-ME, and the product of the reaction catalysed by AYWB-PduL, acetyl phosphate, stimulated AYWB-ME activity. Overall, our data indicate that AYWB-ME and AYWB-PduL activities are finely coordinated by common metabolic signals, like ATP\/ADP ratios and acetyl phosphate, which support their participation in energy (ATP) and reducing power [NAD(P)H]  generation from malate in phytoplasmas.","palabras_clave":"Phytoplasmas|malic enzymes|pathogenesis|energy source"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2784,"idioma_id":4,"titulo":"Physicochemical properties of the antihypertensive agent 2-benzylimidazoline in aqueous and physiological solutions at 25 and 37 °C.","resumen":"Physicochemical properties of the antihypertensive agent 2-benzylimidazoline in aqueous and physiological solutions at 25 and 37ºC","palabras_clave":"Propiedades fisicoquímicas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2786,"idioma_id":5,"titulo":"La Contaminacion Sonora en las Actividades Infantiles","resumen":"El ruido desde siempre ha sido patrimonio de algunas actividades específicas de esparcimiento, ingresó en los hogares, se instaló en las instituciones de salud y en las educativas, tal es así que se ha convertido en un problema social colectivo.","palabras_clave":"CONTAMINACIÓN|SONORA|ACTIVIDADES|INFANTILES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2787,"idioma_id":4,"titulo":"Depth of maximum of air-shower profiles at the Pierre Auger Observatory . II. Composition implications","resumen":"Using the data taken at the Pierre Auger Observatory between December 2004 and December 2012, we have examined the implications of the distributions of depths of atmospheric shower maximum (Xmax),using a hybrid technique, for composition and hadronic interaction models. We do this by fitting the distributions with predictions from a variety of hadronic interaction models for variations in thecomposition of the primary cosmic rays and examining the quality of the fit. Regardless of what interaction model is assumed, we find that our data are not well described by a mix of protons and ironnuclei over most of the energy range. Acceptable fits can be obtained when intermediate masses are included, and when this is done consistent results for the proton and iron-nuclei contributions can be foundusing the available models. We observe a strong energy dependence of the resulting proton fractions, and find no support from any of the models for a significant contribution from iron nuclei. However, we alsoobserve a significant disagreement between the models with respect to the relative contributions of the intermediate components.","palabras_clave":"Auger"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2788,"idioma_id":4,"titulo":"Seasonal-dependence in the responses of biological communities to flood pulses in warm temperate floodplain lakes: implications for the 'alternative stable states' model","resumen":"In floodplains located in temperate regions, seasonal variations in temperature affect biological communities and these effects may overlap with those of the  flood regime. In this study we explored if and how timing (with regard to temperature seasonality) influences the responses of planktonic and free-floating plants communities to floods in a warm temperate floodplain lake and assessed its relevance for determining state shifts. We took samples of  zooplankton, phytoplankton, picoplankton, heterotrophic nanoflagellates and free-floating macrophytes at four sites of the lake characterized by the presence-absence of emergent or free-floating macrophytes along a 2-year period with marked hydrological fluctuations associated to river flood dynamics. We performed ANOVA tests to compare the responses of these communities to floods in cold and warm seasons and among sites. Planktonic communities developed high abundances in response to floods that occurred in the cold season, while the growth of free-floating macrophytes was impaired by low winter temperatures. Spring and summer floods favored profuse colonization by free-floating plants and limited the development of planktonic communities. The prolonged absence of floods during warm periods caused environmental conditions that favored Cyanobacteria growth, leading to a low turbid waters regime. The occurrence of floods early in the warm season caused phytoplankton dilution and promoted free-floating plant colonization and a shift towards a high clear waters state. Zooplankton:phytoplankton biomass ratio was very low during floods in warm seasons, thus zooplankton grazing on phytoplankton seemed to play a minor role in the maintenance of the clear regime.","palabras_clave":"Flood pulses|Temperature seasonality|Zooplankton|Macrophytes|Alternative stable states"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2789,"idioma_id":4,"titulo":"Chlorpyrifos-based insecticides induced genotoxic and cytotoxic effects in the ten spotted live-bearer fish, Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae)","resumen":"Mortality, genotoxicity, and cytotoxicity of the 48% chlorpyrifos (CPF)-based formulations Lorsban* 48E® and CPF Zamba® were evaluated on Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) under laboratory conditions. Induction of micronuclei (MN) and alterations in the erythrocyte\/erythroblast frequencies were employed as end points for genotoxicity and cytotoxicity, respectively. For Lorsban* 48E®, mean values of 0.13 and 0.03 mg\/L were determined for LC50 at 24 and 96 h, respectively, and these concentrations reached mean values of 0.40 and 0.21 mg\/L for CPF Zamba®. Mortality values increased as a positive linear function of the CPF Zamba® concentrations, but not for Lorsban* 48E® concentrations. There was no significant relationship between mortality and exposure time within the 0-96 h period for both formulations. LC50 values indicated that the fish were seven fold more sensitive to Lorsban* 48E® than to CPF Zamba®. Lorsban* 48E® within the concentration range of 0.008-0.025 mg\/L increased MN frequency at both 48 and 96 h of treatment. Similar results were also observed when fish were exposed to 0.052-0.155 mg\/L of CPF Zamba®, regardless of the exposure time. Cellular cytotoxicity was found after Lorsban* 48E® and CPF Zamba® treatments for all concentrations and time exposures, estimated by a decrease in the frequency of mature erythrocytes and a concomitant enhanced frequency of erythroblasts in circulating blood. Furthermore, our results demonstrated that Lorsban* 48E® and CPF Zamba® should be considered as CPF-based commercial formulations with marked genotoxic and cytotoxic properties.","palabras_clave":"MORTALITY|MICRONUCLEUS|ERYTHROCYTE:ERYTHROBLAST RATIO|POECILIIDAE|LORSBAN* 48E®|CHLORPYRIFOS ZAMBA®"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2790,"idioma_id":4,"titulo":"SEROPREVALENCE OF SARCOCYSTIS NEURONA AND ITS ASSOCIATION WITH NEUROLOGICAL DISORDERS IN ARGENTINEAN HORSES","resumen":"Equine protozoal myeloencephalitis (EPM) is generally caused by Sarcocystis neurona and can produce substantial economic losses on equine production in America. The aims of the present study were to evaluate the seroprevalence of S. neurona in the main horse-production area of Argentina and associate it with the occurrence of neurologic disorders. Serum samples were collected from 640 horses in nine Argentinean provinces. Most of the samples correspond to animals &#8805;1.5-year-old from different breeds (n = 628); 12 samples were from younger horses. Further seroprevalence comparison was conducted from the older animals grouped with (n = 148) or without neurologic signs (n = 480). Immunoblot: proteins from 2 × 107S. neurona merozoites were used as antigen on each membrane. Reactivity to antigens with relative mobility of 7, 10, and 16 kDa was considered specific for antibodies against S. neurona; reactivity at 30 kDa was recorded separately. The overall seroprevalence for S. neurona was 26.1% (167\/640), and all the provinces had positive horses. Seroprevalence of animals with neurologic signs was greater (P < .001) than what was observed in normal horses (39.2% vs. 22.1%), with an odds ratio of 2.27. Reactivity at 30 kDa was detected in 71% of all samples. This study identified a wide distribution of S. neurona?positive animals in Argentina and horses with neurologic signs having a greater seroprevalence than normal horses. Sarcocystis neurona infection should be considered for early differential diagnosis and treatment of animals with neurologic disorders to decrease the economic impact of EPM in Argentina.","palabras_clave":"Sarcocystis neurona|immunoblot|EPM|horses|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2791,"idioma_id":4,"titulo":"Chemical composition, nutritional and antioxidant properties of the red edible seaweed Porphyra columbina","resumen":"(chemical score, protein digestibility, PDCAAS and mineral dialyzability) and antioxidant properties (TEAC, DPPH and power reduction) from Porphyra columbina were evaluated. Total dietary fiber (48.02&#8201;±&#8201;1.13&#8201;g\/100&#8201;g dry weight) and protein (24.61&#8201;±&#8201;0.21&#8201;g\/100&#8201;g dry weight) were the two most abundant components in this seaweed. The main saturated and unsaturated fatty acids were C16:0 and C20:5 (n-3), respectively. The limiting amino acid was tryptophan with a chemical score of 57%. Protein digestibility was 74.33&#8201;±&#8201;3.0%. Porphyra columbina has high mineral content with good Na\/K relationship and medium value of potential mineral accessibility (P, Ca and Zn dializability: 18.75&#8201;±&#8201;0.01, 17.62&#8201;±&#8201;0.16 and 16.70&#8201;±&#8201;0.44, respectively). The highest antioxidant properties were obtained with an acetone\/water extraction system. This work provides important information about chemical composition and nutraceutical new properties of P. columbina.","palabras_clave":"MINERAL BIOACCESSIBILITY|NUTRACEUTICAL FOOD|PROTEIN QUALITY, |RED SEAWEEDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2795,"idioma_id":5,"titulo":"Alteración de las propiedades mecánicas de un Udertic ustochrepts tratado con agua enriquecida en sodio","resumen":"        El aumento de la población mundial  requerirá un aumento de la producción de alimentos lo que conllevará a un  aumento de la superficie para cultivo, gran parte de la cual será bajo riego.  El riego con aguas con alto contenido de sodio puede provocar el deterioro  físico de los suelos. En el presente trabajo se trató de evidenciar el efecto  del tratamiento con agua rica en sodio sobre un Udertic ustochrepts en dos tratamientos, con distinto  contenido de sodio. Para esto se hizo uso de una Caja de Corte Directo la cual  permitió realizar la compresión de las muestras además del corte. Se evaluó el  comportamiento a la compresión y al corte obteniéndose los parámetros Cohesión  y Coeficiente de fricción interna.&nbsp; En el ámbito de la Teoría de Estado Crítico  (EC) se analizaron las Líneas Virgen (LV) de ambos tratamientos y el  comportamiento expansivo\/compresivo al corte mediante la ubicación de la Línea de EC. El aumento de  la concentración de sodio provocó una densificación del suelo, mayor  resistencia a la compresión, aumento de la cohesión y esfuerzo cortante. Dentro  de la Teoría  de EC se evidenció una mayor capacidad expansiva del tratamiento más sódico  durante el corte en términos relativos.  ","palabras_clave":"teoría del estado crítico|cohesión|ompresión uniaxial|tensión de preconsolidación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2862,"idioma_id":5,"titulo":"Desarrollo y subdesarrollo latinoamericano. Un análisis crítico del enfoque de los Sistemas de Innovación para el Desarrollo","resumen":"Una de las controversias más importantes dentro del enfoque de los Sistemas de Innovación es si se requiere o no un abordaje particular para los países en desarrollo. El principal antecedente de esta controversia puede encontrarse en las contribuciones de Edquist (2001) y el concepto de Sistemas de Innovación para el Desarrollo, pero también en el enfoque de los sistemas nacionales de aprendizaje (Viotti, 2002) y el concepto de catching-up (Malerba y Nelson, 2007). Este artículo analiza las implicancias de los postulados implícitos en estos enfoques alternativos, considerando específicamente el estudio de los países latinoamericanos. Se argumentará que éstos parten de una concepción lineal y simplista del desarrollo, basados de manera más o menos explícita en tres supuestos: i) que el desarrollo surge de la sucesión de etapas, cuya consecución lleva a la convergencia; ii) que la distancia respecto de la frontera tecnológica internacional determina el tipo de innovación que debe perseguirse; y iii) que el impacto del avance tecnológico en el desarrollo es independiente de las características de la estructura productiva. El análisis realizado permite concluir que la traducción de estos enfoques particulares en elementos para el diseño de políticas públicas puede, de hecho, perpetuar el subdesarrollo.","palabras_clave":"SISTEMAS DE INNOVACIÓN|DESARROLLO|AMÉRICA LATINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2864,"idioma_id":4,"titulo":"Synthesis of pure-phase Sr2MgMoO6 nanostructured powder by the combustion method","resumen":"Pure-phase Sr2MgMoO6 (SMMO) nanopowder was obtained by combustion synthesis (CS)from an aqueous solution of metal nitrates, glycine and ammonium nitrate and subsequent treatment in air at 900 ºC. The morphological and structural characterization was performed by X-Ray diffraction (XRD), N2 physisorption and scanning electron microscopy (SEM). This nanostructured powder presents average crystallite size of ~150 nm and a sponge-like morphology composed of highly interconnected crystallites and an effective specific area of 5.6 m2\/g.EIS measurements indicate ASRvalues as low as 0.07 ohmcm2 at 800 C","palabras_clave":"Sr2MgMoO6|NANOSTRUCTURED POWDER|COMBUSTION SYNTHESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2867,"idioma_id":4,"titulo":"The contribution of ethnobotany and experimental archaeology to interpretation of ancient food processing: methodological proposal based on the discussion of several case estudies on Prosopis ssp., Chenopodium ssp.,  and Cucurbita ssp. from Argentina","resumen":"Thepurpose of this paper is to discuss recent methodological advances inArgentinean archaeobotany that incorporate the use of ethnobotany as anethnoarchaeological tool for interpreting ancient food systems in SouthAmerica. This is an integrative paper that takes into account both publishedand unpublished results. The role of ethnobotany is examined with reference toethnobotanical and experimental food processing studies on Prosopis, a wild food plant, and two cultivated ones Chenopodium quinoa and Cucurbita spp., followed by laboratory examinations withmicroscopy to identify diagnostic changes in plant morphology and anatomy.Experimental materials are then compared with archaeological specimens toidentify different types of ancient food processing, and to make inferencesabout prehistoric post-harvest systems. We demonstrated that: (a) it wascritical for our food processing studies to achieve the best taxonomicalidentification resolution that the plant remains allow; (b) a multiproxy approach was highly advantageous; (c)ethnobotanical data were crucial to identify food processing pathways ofindividual plants and combinations of them; (d) the understanding ofcommensality in the wider sense of the term allows us to determine foodpatterns both in domestic and funerary contexts. These investigations, thefirst ones of this type in Argentina, constitute a qualitative step in the methodologyfor this country because they expand our abilities to interpret the nature ofroutine plant processing from archaeobotanical assemblages, and they are also asubstantial contribution to the development of our discipline in generalbecause the taxa discussed in this paper are distributedthroughout South America, as well as in other parts of the world.","palabras_clave":"ARGENTINA|ARCHAEOBOTANY|ETHNOBOTANY|EXPERIMENTAL STUDIES|FOOD PROCESSING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2869,"idioma_id":4,"titulo":"Search for new phenomena in events with a photon and missing transverse momentum in pp collisions at s&#8730;=8 TeV with the ATLAS detector","resumen":"Results of a search for new phenomena in events with an energetic photon and large missing transverse momentum with the ATLAS experiment at the LHC are reported. Data were collected in proton-proton collisions at a center-of-mass energy of 8 TeV and correspond to an integrated luminosity of 20.3&#8201;&#8201;fb-1. The observed data are well described by the expected Standard Model backgrounds. The expected (observed) upper limit on the fiducial cross section for the production of events with a photon and large missing transverse momentum is 6.1 (5.3) fb at 95% confidence level. Exclusion limits are presented on models of new phenomena with large extra spatial dimensions, supersymmetric quarks, and direct pair production of dark-matter candidates.","palabras_clave":"ATLAS|LHC|HIGH ENERGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2870,"idioma_id":5,"titulo":"Evaluación de la ingesta diaria de cafeína en niños y adolescentes de Argentina. Estudio piloto","resumen":"    La cafeína (1,3,7 trimetilxantina) es  un alcaloide de la familia de las xantinas. Está presente en una gran cantidad  de bebidas como café, té, cacao, mate, guaraná, bebidas gaseosas y bebidas  energizantes, y alimentos que son consumidos por adultos, adolescentes y niños.  A fin de obtener información acerca de la ingesta de cafeína en población  infantil y adolescente de Argentina, se plantearon los siguientes objetivos de  trabajo: a) estimar la ingesta diaria de cafeína en niños y adolescentes que  residen en conglomerados urbanos de Argentina; b) estudiar la asociación de  dicha ingesta con distintas variables tales como el género, la edad, el nivel  socioeconómico (NSE) y el lugar de residencia; c) estudiar la relación de la  ingesta de cafeína con la duración del sueño y d) valorar la contribución de  las distintas bebidas a la ingesta diaria de cafeína.&nbsp; Se obtuvieron los datos de consumo de bebidas  de 425 participantes de hasta 20 años de edad, residentes de distintas ciudades  del país y de diferente NSE. Los resultados mostraron que la  ingesta diaria promedio de cafeína (11, 43, 76, 132 y 233 mg\/día) aumentó con  la franja etaria (menores de 2, de 3 a 5, de 6 a 12, de 13 a 17 y de 18 a 20  años, respectivamente), aunque al relacionarla con el peso corporal (mg\/kg\/día)  el aumento no fue tan marcado. El  50% de los niños de hasta 2 años evaluados, nunca había consumido bebidas con  cafeína. Por el contrario, a partir de 3 años en adelante más del 90% sí  consumieron regularmente por lo menos una bebida con cafeína. Las ingestas  promedio calculadas para los niños y adolescentes evaluados resultaron ser  superiores a las reportadas por otros autores para otros países. No se  encontraron diferencias en la ingesta según el género, el lugar de residencia o  el NSE. No se encontró relación entre la ingesta de  cafeína y la duración del sueño para ningún grupo etario, a excepción de  la franja etaria de 18 a 20 años en la que se observó una disminución  significativa en la duración promedio del sueño para el grupo de individuos con  ingesta extrema. Las bebidas gaseosas cola se mostraron como principales  contribuyentes a la ingesta promedio de cafeína, aunque el mate también se  destacó en ese aspecto. Como conclusiones generales de este trabajo se destaca  que se logró caracterizar la ingesta de cafeína en niños y adolescentes y  establecer la composición de dicha ingesta en cuanto a sus contribuyentes  mayoritarios y minoritarios. Por último, si bien se podría clasificar a las  ingestas promedio obtenidas en este estudio como elevadas con respecto a las  reportadas para otros países, se debe considerar que no se ha definido un valor  de ingesta diaria recomendada para niños y adolescentes.  ","palabras_clave":"Cafeina|Niños|Adolescentes|Ingesta"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2871,"idioma_id":4,"titulo":"Diversity and evolution of sexually dimorphic mental and lateral glands in Cophomantini treefrogs (Amphibia: Anura: Hylidae)","resumen":"We describe the structure and histochemistry of mental and lateral glands in a representative array of 28 species of five genera of the Neotropical hylid frog tribe Cophomantini. Structural diversity was coded in 15 characters that were optimized on the most recent phylogenetic hypothesis. Mental and lateral glands occur in 17 species and 10 species, respectively, whereas nine species have both. Each glandular concentration may have two types of sexually dimorphic skin glands (SDSGs), specialized mucous and specialized serous glands, which occur independently or mayco-occur. Distinctive characteristics related to these glands are shape, aspect of the secretion, disposition, and distribution. The occurrences of mental and lateral glands, and the characters derived from macroscopic and microscopic examinations, have an intricate taxonomic distribution, with differing levels of homoplasy. The function of SDSGs in Cophomantini is currently unknown. However, based on structural and histochemical similarities to SDSGs from other species of amphibians where experimental evidence exists, we infer they might be involved in the secretion of chemical signals during courtship behaviour. The distribution pattern of these glands, along with theexistence of different signals (i.e. acoustic, visual, tactile), suggests the presence of multimodal signalling for some species of the tribe.","palabras_clave":"AMPHIBIAN|BREEDING|CHEMICAL COMMUNICATION|SKIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2873,"idioma_id":5,"titulo":"Construccion y primeros ensayos de una turbina detesla para generacion de energia electrica a partir de un sistemaconcentrador solar termico","resumen":"no disponible","palabras_clave":"TURBINA|DE TESLA|ENERGIA RENOVABLE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2874,"idioma_id":4,"titulo":"THE FIRST RECORD OF PERMIAN FLORA IN THE ANSILTA FORMATION (WESTERN PRECORDILLERA OF ARGENTINA) AND ITS REGIONAL CORRELATION","resumen":"THE Ansilta Formation (Harrington, 1971) is one of thethickest upper Paleozoic sequences of the western Precordillerain San Juan Province (Argentina). Its lower section includesdiamictites and mudstones with dropstones, whichwere the subject of study in previous papers about this unit(Amos and Rolleri, 1965; López Gamundí, 1986).The facies association analysis by Limarino et al. (2011)led to the interpretation of the palaeoenvironmental evolutionof the Ansilta Formation and the correlation of its depositswith the regional stratigraphic scheme proposed byLimarino et al. (2006) in the western basins of Argentina.In this context, the first facies association (FA I), consistingof diamictites, mudstones with dropstones and sandstones,(occasionally pebbly) corresponds to the Gondwanan glacialinterval recognized in basins in western Argentina","palabras_clave":"Conífera|Glossopteris|Paleoflora|Pérmico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2875,"idioma_id":4,"titulo":"Multiple Geophysical methods examining neotectonic structures in the western foothills of the Sierra de El Maitén (Argentina), North Patagonian Andes","resumen":"A high-resolution geophysical study was carried out in a region of the retroarc of the PatagonianAndes located on the western slope of the Sierra de El Maitén. This structure is characterized by animbricated west-vergent fault system developed in the orogenic front area of the North PatagonianAndes that has uplifted. Oligocene volcanic rocks (Ventana Formation) affect Miocene toQuaternary sediments. Even though neotectonic fault scarps are affecting Quaternary deposits in thefoothills of this range, no direct observation of slip in Quaternary strata was determined. The mainobjective of this study is to determine geometry of recognized neotectonic structures, characterizingthem by variations in magnetic susceptibility, density, and p-wave velocities. The combined applicationof different geophysical methods has allowed the characterization of the bedrock geometry andthe determination of neotectonic displacements along faults. The potential field model and its integrationwith a seismic profile show the accurate geometry of this tectonic zone, which is crucial forseismogenic hazard analysis, in the area of northern Patagonia, a highly significant economic zonedue to tourism with several towns (El Maitén, Esquel, and San Carlos de Bariloche) dispersedthroughout the area of young tectonic activity.","palabras_clave":"geofisica|neotectonica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2876,"idioma_id":5,"titulo":"METAHEURÍSTICAS MULTIOBJETIVO CARDUMEN DE PECES ARTIFICIALES (FAFS) Y OPTIMIZACIÓN EVOLUCIONARIA POR ENJAMBRE DE PARTÍCULAS CON TOPOLOGÍA ESTOCÁSTICA GLOBAL INDIVIDUAL (FEPSO GIST). PARTE I: ANTECEDENTES Y DESARROLLOS TEÓRICOS","resumen":"El presente trabajo describe un modelo para la Optimización del Grado de Desbalance de Cargas en una Red Trifásica de Distribución de EnergíaEléctrica (SDEE) en Baja Tensión (BT). Se presenta la integración de dos novedosas metaheurísticas: la FEPSO GIST (Fuzzy-MultiObjective ParticlesSwarm Optimization with Global\/Individual Stochastic Topology), desarrollada por el autor, y la FAFS (Fuzzy-MultiObjective Artificial Fish School), cuyaextensión multiobjetivo es propuesta por el autor, valuando la función de aptitud mediante conjuntos difusos. El problema propuesto ya ha sido resueltoen un trabajo presentado por el autor, mediante la metaheurística FPSO, y su solución constituye una referencia para comparar resultados. Entre los inconvenientes producidos por un elevado grado de desbalance en las fases del sistema, se consideran la minimización de las pérdidas técnicas y la mejora del perfil de tensiones. Ambos aspectos, relativos al uso racional de la energía propiciado desde el lado de la oferta, son observados por la autoridad regulatoria. Se presenta, adicionalmente, un modelo matheurístico que combina el enfoque clásico del problema, empleando programación lineal entera-mixtacon las dos metaheurísticas introducidas, FEPSO GIST y FAFS. Se comparan resultados al aplicar los modelos sobre el mismo SDEE BT considerado en el enfoque resuelto vía FPSO. En esta Parte II, se desarrollan los modelos específicos y se presenta su aplicación al problema.","palabras_clave":"CARDUMEN DE PECES ARTIFICIALES|DESBALANCE DE CARGAS|ENJAMBRE DE PARTÍCULAS|METAHEURÍSTICAS|SISTEMAS DE DISTRIBUCIÓN DE ENERGÍA ELÉCTRICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2877,"idioma_id":4,"titulo":"Synthesis and Biological Evaluation of Salpichrolide Analogues as Antiestrogenic Agents","resumen":"The antiestrogenic activity of three natural salpichrolides A, G and B (1, 3 and 4) and of five synthetic analogs containing an aromatic D ring and a simplified side chain (5-9), was evaluated on MCF-7 cells. The 2,3-ene-1-keto steroids 8 and 9 were obtained from 3beta-acetoxy-17(13\/18)-abeo-5alphaH-pregna-13,15,17-trien-20-one, the key step for these syntheses being a Wharton carbonyl rearrangement of a 1,2-epoxy-3-keto steroid to the allylic alcohol using hydrazine hydrate. The antiestrogenic activity was  evaluated by performing dose-response experiments in ER(+) MCF-7 breast cancer cells. Dose dependent proliferation was quantified via [3H]-thymidine incorporation after 3 days treatment. Salpichrolides A, G and B and analogs 5, 8 and 9 were active as antiestrogens with compound 9 being the most active of the synthetic analogs. Compounds 5 and 9 were also evaluated against the ER(-) cell line MDA-MB-231 and shown to be inactive.","palabras_clave":"SALPICHROLIDES|ANTIESTROGENIC ACTIVITY|ANTIPROLIFERATIVE ACTIVITY|WITHANOLIDES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2878,"idioma_id":4,"titulo":"Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome","resumen":"The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome  (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to  investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures,  steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1),  claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-  1 (FLT-1)\/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the  percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in  CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels  were decreased in the OHSS compared to the control TRAP reversed these parameters. Our  findings  indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats.","palabras_clave":"ANGIOGENESIS|VEGF|OHSS|OVARY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2879,"idioma_id":4,"titulo":"The turbidity front as a habitat for Acartia tonsa (Copepoda) in the Río de la Plata, Argentina-Uruguay","resumen":"Acartia tonsa is one of the most abundant copepod species in estuaries worldwide. In the Río de la Plata, its highest densities appear to occur in an area of low quality food (detritus): the turbidity front (TF). The objective of this study was to understand how trophic and oceanographic drivers contribute to the high densities of A. tonsa in the  Río de la Plata TF. The patterns of spatial distribution and density of this species were analyzed in relation to oceanographic and biological attributes of the system. The egg production rate (EPR) in the TF was evaluated as a measure of fitness, and a stable isotope analysis indicated the possible sources of organic matter in the species? diet. This study confirmed that the highest observed densities of A. tonsa were mostly associated with the TF, where high suspended matter and low Chl-a occur. Immediately offshore from the TF, copepod densities decreased and the maximum Chl-a values were found. Females close to the estuarine turbidity maximum (ETM) had a lower EPR than those closer to the high Chl-a concentrations. Within the TF, A. tonsa apparently fed on detritus close to the ETM and phytoplankton close to the edge of the TF. The report includes a discussion of how retention processes, two layered flow and the life history strategy of A. tonsa could be contributing to the development of high densities (more than 10,000 ind m-3) of this species in the inner estuarine zone, despite the poor quality of food available for development in that area. A. tonsa can live and prosper in areas with high turbidity and low chlorophyll concentrations. This trait exemplifies the plasticity of this species and helps explain why it is a key species in many worldwide estuaries.","palabras_clave":"COPEPOD DISTRIBUTION|TURBIDITY MAXIMUM|EGG PRODUCTION|RETENTION|BRACKISH WATER|STABLE ISOTOPES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2880,"idioma_id":5,"titulo":"EVOLUCIÓN DE LA CONCENTRACIÓN DE SÓLIDOS ÚTILES EN LECHE DE TAMBOS DEL NE DE LA PROVINCIA DE SANTA FE: PERÍODO 2003-2013","resumen":"El noreste de la provincia de Santa Fe, con algunas restricciones edafo-climáticas, presenta ventajas respecto a otras zonas del país, por su proximidad a grandes empresas procesadoras de productoslácteos. El objetivo, fue estudiar la evolución de la concentración de sólidos útiles (SU) en tambos de la región NE de Santa Fe; departamentos: San Justo, Vera, Gral. Obligado, Norte de SanJavier, durante el período (2003-2013). Se solicitó a las industrias lácteas, promedios mensuales de porcentaje de Materia Grasa (MG) y proteína (PT) en leche. Se realizó un análisis estadístico de las variables mediante ANOVA y test a posteriori de comparaciones múltiples (test de Tukey), entre cada departamento. Considerando los valores informados al inicio del período, existió un incremento de la concentración de SU en la leche producida en los tambos de la región, evidenciado en el aumento del % PT en los últimos años. Se alcanzaron valores similares a la región pampeana.","palabras_clave":"leche bovina|sólidos útiles|Noreste de Santa Fe"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2881,"idioma_id":4,"titulo":"Occupancy and abundance of large macaws in the Beni savannahs, Bolivia","resumen":"VER ADJUNTO","palabras_clave":"ARA ARARAUNA|ARA CHLOROPTERUS|ARA GLAUCOGULARIS|BOLIVIA|CONSERVATION|MACAW|OCCUPANCY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2882,"idioma_id":4,"titulo":"Brain antioxidant responses to acute iron and copper intoxications in rats","resumen":"Dose- and time-dependent antioxidant responses to Fe (0-60 mg kg(-1)) and Cu overloads (0-30 mg kg(-1)) in rat brains are described by the C50 and the t1\/2, the brain metal concentration and the time for half maximal oxidative responses. Brain GSH and the GSH\/GSSG ratio markedly decreased after Fe and Cu treatments (50-80%) with a t1\/2 of 9-10 h for GSH and of 4 h for GSH\/GSSG for both metals. The GSH\/GSSG ratio was the most sensitive indicator of brain oxidative stress. The decrease of GSH and the increase of in vivo chemiluminescence had similar time courses. The C50 for brain chemiluminescence, GSH and hydrophilic and lipophilic antioxidants were in similar ranges (32-36 &#956;g Fe g(-1) brain and 10-18 &#956;g Cu g(-1) brain), which indicated a unique free-radical mediated process for each metal. The brain concentration of hydrophilic and lipophilic antioxidants decreased after Fe and Cu loads; hydrophilic antioxidants decreased by 46-68% with a t1\/2 of 10-11 h and lipophilic antioxidants decreased by 75-45% with a t1\/2 of 10-12 h. Cu,Zn-SOD and CAT activities and the protein expression were adaptively increased (100-90% after Fe and Cu loads), with a t1\/2 of 8-12 h. GPx-4 activity decreased after both metal loads by 73-27% with a t1\/2 of 8-4 h with decreased protein expression.","palabras_clave":"iron|cupper|SOD|Catalase|GPX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2884,"idioma_id":5,"titulo":"subprograma de salud bucal 'el hospital y los chicos':del diagnóstico del estado dental a la priorización de programas necesarios","resumen":"Los objetivos de este trabajo fueron determinar el estado dental de la población bajo estudio, detectar subgrupos de riesgo específico para enfermedades bucales y proponer estrategias de intervención apropiadas para la promoción de la salud bucal para ellos. Método: sobre la base de datos del subprograma de salud bucal 'El hospital y los chicos' se efectuó un estudio descriptivo del estado dental sobre 277 niños entre 2 meses y 13 años de edad asistentes al CDlF NO1 1. Guaymallén, Mendoza. Se registraron: ceod, CPOD, ceos CPOS, índice de Necesidad de tratamiento de caries, índice de Paca de Silness y Loe, ICDAS II, y datos demográficos. Además, como parte del programa, se llevó a cabo la enseñanza de Técnicas de Higiene Bucal adecuada a la edad, dirigidas a madres y niños, y una topicación de flúor profesional siguiendo protocolos específicos según edad del niño. Resultados: la población libre de caries fue del 31,4%, mientras que el 68,6% tuvo experiencia de caries pasada o presente. La media de la sumatoria de ceod+ cpod fue 4,91 I 5, con una carga de enfermedad muy alta denotada por un componente c+C de 4.25~4.55. Presentó un valor para ceos+CPOS de 9,22+11 96 y de c+CS de 6.8918 61. En cuanto a la severidad de las lesiones de caries expresadas con las categorías de ICDAS II del 2 al 6, se observó que las medias mayores corres- , ponden al nivel 6 (x2 Friedman= 20,999, p= 0,000). La media de necesidad de tratamiento de caries fue de 5,74, pero los niveles 8 y más abarcan al 33.2% de la población de estudio Se observó un aumento progresivo de estos indicadores en la primera infancia comenzando en la primera franja etaria con una media de ceod+CPOD de 0.8811,92, de 3, 93t4.65a los tres años, de 6,38+6,36 a los 5 años, y de 8,40+5,47 a los 7 años, siendo esta población la que presentó el mayor valor del indicador (x2 Kruskall Wallis= 104,637, p=O,OO). El índice CPOD fue de 1,35~1,34 a los 7 años y de 4.65+3 99 a los 9 ( x2 Kruskall Wallis =17,609 y p=0,001) Conclusiones~ este grupo de niños de alto riesgo social presentó elevados índices de caries y de necesidad de tratamiento, que requerirán de un sistema de salud que pueda contenerlos. Al observar las medias de ceod+CPOD según las categorías de edad se pone de manifiesto una tendencia a agravarse el estado dentario en la primera infancia, llegando a valores muy por encima de la media general para los 5, 6 ,7 y 8 años El CEOD también tiende a aumentar con la edad, poniendo en evidencia la susceptibilidad de caries de los molares permanentes erupcionados Las tendencias de los indicadores permitieron reconocer dos subgrupos de riesgo para desarrollar programas preventivos´ el de niños de O a 3 años, y el de 6 a 12, es decir niños escolares. Se sugieren dos programas prioritarios Materno- infantil y Protección de ler molar permanente.","palabras_clave":"CARIES|NIÑOS|ESTADO DENTAL|PROGRAMAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2886,"idioma_id":4,"titulo":"FIRST ISOLATION OF ACINETOBACTER JOHNSONII CO-PRODUCING PER-2 AND OXA-58 &#914;-LACTAMASES.","resumen":"Multidrug resistance in Acinetobacter baumannii has been described in different countries, but its incidence varies among Acinetobacter non-baumannii species. In particular, the great majority of Acinetobacter johnsonii isolates were found to be fully susceptible, and few reports have described mechanisms of resistance to antimicrobial agents","palabras_clave":"Acinetobacter johnsonii|Multidrug resistance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2951,"idioma_id":4,"titulo":"Copper nanoparticles applied to the preconcentration and electrochemical determination of &#946;-adrenergic agonist: An efficient tool for the control of meat production","resumen":"A novel method for preconcentration and electrochemical detection of zinterol in bovine urine samples was developed. In order to improve the limit of detection, the surface of a screen-printed carbon electrode was modi&#64257;ed with electrodeposited metal copper nanoparticles. The experimental electro- deposition optimization was performed using a central composite design (CCD), involving the variables: precursor concentration, potential and time applied. Copper nanoparticles were characterized by transmission electron microscopy, scanning electron microscopy, cyclic voltammetry, and energy dispersive X-ray spectroscopy. Mesoporous shuttle-like copper oxide nanoparticles were used for the preconcentration step to avoid interferences with many compounds present in the sample matrix. The optimal working conditions for the preconcentration approach were found by means of both two-level fractional factorial and CCD designs. The obtained enhancement factor for a sample volume of 30 mL was 35 fold. The calibration curve showed linearity between 0.5 and 45 ng mL-1 and the limit of detection was 0.16 ng mL-1. The intra and inter assay coef&#64257;cients of variability were below 4% and 5%; respectively.","palabras_clave":"ZINTEROL|ELECTROCHEMICAL |SCREEN-PRINTEDCARBONELECTRODE|PRECONCENTRATION |ADRENERGIC AGONIST|NANOTECHNOLOGY |COMPOSITEDESIGN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2952,"idioma_id":5,"titulo":"Evolución demográfica y territorial de Paraná (Arg.) a través del siglo XX y su relación con la calidad de vida","resumen":"La heterogeneidad socio-espacial de las ciudades es un claro testimonio de la diferente calidad de vida en que vive su población. Esos contrastes pueden ser considerados como resultado de diversas transformaciones territoriales que se van sucediendo dentro de la ciudad en el marco de procesos geográficos, económicos, políticos y sociales, a diferentes escalas. El presente trabajo tiene por objeto analizar, en primera instancia, la evolución demográfica y espacial de la planta urbana del municipio de Paraná, considerando una periodización basada en las fechas en las que fueron realizados los censos nacionales de población, hogares y viviendas de la República Argentina y, en segunda instancia, vincular los resultados obtenidos con las características de las etapas económicas que han sido establecidas para el caso argentino. En tercera instancia, se establecen relaciones entre esa dinámica socio-territorial y la distribución geográfica actual de la calidad de vida en Paraná. Con esa finalidad, se considera la geometría urbana como manifestación espacial de diversos procesos sociales y la base de datos generada se sustenta en datos emanados de los Censos Nacionales de Población del período 1869-2010 y en archivos catastrales y planimétricos municipales. Para la medición de la calidad de vida se ha construido, a escala de radios censales, un índice resumen partiendo de una serie de indicadores seleccionados de fuentes censales (Velázquez, 2008). Entre los principales resultados surge que la expansión territorial y demográfica muestra características diferenciales a lo largo del periodo bajo estudio. A su vez, se ha encontrado que ambas dimensiones del crecimiento urbano no expresan la misma proporcionalidad siendo, en la actualidad, relativamente mayor la expansión espacial que la demográfica. Por otra parte, la estructura espacial de la diferenciación socioeconómica actual del aglomerado sigue, grosso modo, los patrones existentes en las propuestas modélicas formuladas para las ciudades latinoamericanas. Finalmente, la distribución de calidad de vida encuentra ligazones con la evolución del crecimiento urbano de Paraná.","palabras_clave":"Crecimiento urbano |Calidad de Vida|Modelos Urbanos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2956,"idioma_id":4,"titulo":"Biomass dynamics of the two dominant SW Atlantic Spartina species and its implications on the saltmarsh organic matter accumulation\/exportation","resumen":"We  present a comparative analysis of the biomass dynamics of the two  dominant Spartina  plant  species inSouth West Atlantic saltmarshes: Spartina  densiflora Brong.  (high intertidal zone) and Spartina  alternifloraLoesel.  (mid-low intertidal zone). We assessed aboveground biomass, live:  dead ratios, net production,mortality and turnover rates, and then  used this information to understand if saltmarshes dominatedby one or  the other Spartina  species  have different ecosystemic roles in the recycling of organic  matter.Through field sampling we found that S.  densiflora had  larger live, dead and total biomass than S.  alterni-flora.  When comparing within each species, S.  alterniflora had  larger live than dead biomass for most ofthe year, while S.  densiflora had  more dead than live biomass. Through the Weigert and Evans (1964)  netaerial primary production (NAPP) estimating method we found that  S. densiflora had  larger annual NAPP,annual mortality and live turnover rates than S.  alterniflora.  In both species the amount of NAPP wassimilar to the amount of annual  mortality. These results suggest that S.  densiflora aboveground  biomassis a carbon accumulation zone, while S.  alterniflora is  a carbon recycling one.","palabras_clave":"Aboveground biomass|Primary production|Mortality|Spartina alterniflora|Spartina densiflora"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2963,"idioma_id":5,"titulo":"Acuerdo Reglamentario A 1233 (T.S.J. Córdoba","resumen":"No ha sido requerido","palabras_clave":"PRUEBA|PERITOS|DESIGNACIÓN Y ACTUACIÓN|NULIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2964,"idioma_id":5,"titulo":"'Reflexiones en torno a la vinculación entre materiales, movimientos y configuraciones gestuales en la música tonal'","resumen":"Una concepción gestual de una obra musical nos aproxima a concebirla comouna unidad compleja, y nosvincula con un tipo de conocimiento reflexivo,activo, experiencial, productivo, reorganizado, sistémico, relacional,inacabado, paradojal. Esta concepción parte de percepciones totalizadoras de las interacciones detodos sus materiales constitutivos insertas en contextos culturalesespecíficos. Desde estasperspectivas, emergen preguntas en cuanto a aquellos comportamientos musicalesque quedan ocultos, invisibilizados, no-percibidos. Estos posicionamientospermiten aventurarnos en una escucha musical no guiada, únicamente, por unorden lineal, dogmático y normativo, sino que nos invita a plantearnos otrasescuchas que puedan generar metodologías de análisis desconocidas hasta elmomento y que nos acerque a comprender la significación de una obra musicalconcebida como un emergente cultural. Perotambién plantea un desafío con una gran carga y compromiso emocional ycognitivo, dado que nos obliga a revisar y reconstituir nuestras categorías deconocer para resituar espacios observacionales, criterios, sujetos, códigos,discursos, con el fin de propiciar condiciones para problematizar, reflexionar,observar, discutir, formular ideas consigo mismo, con los otros y con larealidad. En esta idea deorganización compleja subyace un concepto polifónico, ya que la organizaciónune, forma, transforma, mantiene, estructura, ordena, cierra, abre un sistema.La escucha de la interacción de los materiales musicales, desde estasperspectivas organizacionales y desde una concepción de análisis gestual,permitirá percibir no sólo dichas estructuras sino otras posibilidadesperceptuales que den cuenta de nuevas organizaciones formales. El desorden, elconflicto, las contradicciones que generan muchas obras en referencia al ordenformalizado, no hace más que dar cuenta de que la organización de dicho ordense encuentra entrampada en su propio determinismo. Y si bien hay obras que seajustan a dicho determinismo, lo que necesitamos son otros principios de ordenque surjan de las interacciones de los materiales de las propias obras. Así,los términos orden, desorden, conflicto, organización, interacción, serántérminos que necesariamente deberán ser concebidos en conjunto, tanto en suconcurrencia como en su antagonismo. Entonces, la riqueza, lacomplejidad y la pertinencia de nuestra concepción de obra musical está eninterdependencia recíproca con la riqueza, la complejidad, la pertinencia denuestra concepción de la vida y la sociedad y con la reflexión propia delsujeto que analiza.","palabras_clave":"FORMAS MUSICALES|GESTUALIDAD MUSICAL|SIGNIFICACIÓN MUSICAL|ORGANIZACION COMPLEJA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2965,"idioma_id":4,"titulo":"Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells","resumen":"The synthetic nonapeptide 1-desamino-8-D-arginine vasopressin (dDAVP) can reduce tumor cell growth through agonist action on the vasopressin V2 receptor. A structure-antiproliferative activity relationship analysis of dDAVP was performed using the alanine scanning technique on the aggressive MDA-MB-231 human breast carcinoma cell line. The results from this analysis demonstrated that the amino acids located at the loop of dDAVP are important for the antiproliferative activity of dDAVP, highlighting the key role of the N-terminal region of the peptide in the interaction with the tumor cell surface receptor. The findings from this study present novel strategies for designing improved compounds with enhanced stability for cancer therapy.","palabras_clave":"1 DESAMINO 8 D ARGININE VASOPRESSIN |ANTIPROLIFERATIVE AGENT|VASOPRESSIN V2 RECEPTOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2966,"idioma_id":4,"titulo":"High expression of sLex associated with poor survival in Argentinian colorectal cancer patients","resumen":"Aim: Colorectal cancer (CRC) is one of the most prevalent malignancies in Argentina with 11,043 new cases and 6,596 deaths estimated to have occurred in 2008. The present study was developed to clarify the differential expression of MUC1, MUC2, sLex, and sLea in colorectal cancer patients and their relationship with survival and clinical and histological features. Methods: Ninety primary tumor samples and 43 metastatic lymph nodes from CRC patients were studied; follow-up was documented. Twenty-six adenoma and 68 histological normal mucosa specimens were analyzed. An immunohistochemical approach was applied and statistical analysis was performed. Results: In tumor samples, MUC1, sLea, and sLex were highly expressed (94%, 67%, and 91%, respectively); also, we found a significantly increased expression of the 3 antigens in primary tumors and metastatic lymph nodes compared with normal mucosa and adenomas. MUC2 was expressed in 52% of both normal mucosa and CRC samples; this reactivity significantly decreased in metastatic lymph nodes (p&lt;0.05). A multiple comparison analysis showed that MUC1 and sLex discriminated among 3 groups: normal, adenoma, and CRC tissues. The increase of sLex expression showed an association with recurrence, and survival analysis showed that a high sLex staining was significantly associated with a poor survival. By multivariate analysis MUC1 inmunoreactivity correlated positively and significantly with tumor size, while MUC2 expression showed the opposite correlation. Conclusions: The correlation of sLex overexpression in primary tumors and metastatic lymph nodes, the discrimination among the normal, adenoma, and CRC groups based on sLex expression, as well as its association with recurrence and survival, all suggest a prognostic role of sLex in Argentinian CRC patients.","palabras_clave":"COLORECTAL CANCER|MUCIN|SIALYL LEWIS X ANTIGEN|SURVIVAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2967,"idioma_id":4,"titulo":"Effect of the endosymbiotic pea crab Calyptraeotheres garthi on the metabolic rate and oxidative status of the slipper limpet Crepidula cachimilla from the southwestern Atlantic","resumen":"Parasites may induce metabolic changes and imbalances in the redox status of hosts. This study tested the effect of parasites on the O2 consumption rate (O2-CR) of hosts, and explored the link between O2-CR and oxidative stress in parasitized hosts. We used the symbiotic pea crab Calyptraeotheres garthi and its slipper limpet host Crepidula  cachimilla as models. The O2-CR of long-term (3 months) infested limpets was 2.5 times greater than that of long-term uninfested limpets. Also, the O2-CR of limpets stripped of crabs 24 h before measurements was intermediate between that of long-term infested and uninfested limpets. These results indicate a parasitic relationship between C. garthi and  Cr. cachimilla, and suggest that the effect of the parasite on the metabolic rate of limpets is reversible. Lastly, the activity of two antioxidant enzymes (CAT and GST) as well as lipid peroxidation did not vary between infested and uninfested limpets. Thus, increased O2-CR  is not necessarily coupled with oxidative stress in pea crab-parasitized slipper limpets.","palabras_clave":"OXIDATIVE STRESS|OXYGEN CONSUMPTION|PINNOTHERIDAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2968,"idioma_id":4,"titulo":"Akaline, saline and mixed saline-alkaline stresses induce  physiological and morfo-anatomical changes in Lotus tenuis shoots.","resumen":"Saline, alkaline and mixed saline?alkaline conditions frequently co-occur in soil. In this work, we compared these plant stress sources on the legume Lotus tenuis, regarding their effects on shoot growth and leaf and stem anatomy. In addition, we aimed to gain insight on the plant physiological status of stressed plants. We performed pot experiments with four treatments: control without salt (pH = 5.8; EC = 1.2 dSm1)and three stress conditions, saline (100 mM NaCl, pH = 5.8; EC = 11.0 dSm1), alkaline (10 mM NaHCO3, pH= 8.0, EC = 1.9 dSm1) and mixed salt?alkaline (10 mM NaHCO3 + 100 mM NaCl, pH = 8.0, EC = 11.0 dSm1). Neutral and alkaline salts produced a similar level of growth inhibition on L. tenuis shoots, whereas their mixture exacerbated their detrimental effects. Our results showed that none of the analysed morpho-anatomical parameters categorically differentiated one stress from the other. However, NaCl- and NaHCO3-derived stress could be discriminated to different extents and\/or directions of changes in some of the anatomical traits. For example, alkalinity led to increased stomatal opening, unlike NaCl-treated plants, where a reduction in stomatal aperture was observed. Similarly, plants from the mixed saline?alkaline treatment characteristically lacked palisade mesophyll in their leaves. The  stem cross-section and vessel areas, as well as the number of vascular bundles in the sectioned stem were reduced in all treatments. A rise in the number of vessel elements in the xylem was recorded in NaCl-treated plants, but not in those treated exclusively with NaHCO3.","palabras_clave":"ALKALINITY|OSMOTIC POTENTIAL|PROLINE|SALINITY|SHOOT ANATOMY|TRANSPIRATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2969,"idioma_id":4,"titulo":"The complete nucleotide sequence of the carbapenem resistance-conferring conjugative plasmid pLD209 from a Pseudomonas putida clinical strain reveals a chimeric design formed by modules derived from both environmental and clinical bacteria","resumen":"The complete sequence of the carbapenem-resistance-conferring conjugative plasmid pLD209 from a Pseudomonas putida clinical strain is presented. pLD209 is formed by 3 well-defined regions: an adaptability module encompassing a Tn402-like class 1 integron of clinical origin containing blaVIM-2 and aacA4   gene cassettes, partitioning and transfer modules, and a replication   module derived from plasmids of environmental bacteria.                       pLD209 is thus a mosaic of modules originating in   both the clinical and environmental (nonclinical) microbiota.","palabras_clave":"PLASMID|VIM-2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2971,"idioma_id":4,"titulo":"Molecular structure, experimental and theoretical 1H and 13C NMR chemical shift assignment of cyclic and acyclic &#945;,&#946;-unsaturated esters","resumen":"The experimental 1H and 13C NMR spectra of 13   phenyl cinnamates and four 4-methylcoumarins were investigated and their   chemical shifts assigned on the basis of the two-dimensional spectra.   For the unsubstituted cinnamic acid phenyl ester, optimized molecular structures were calculated at a B3LYP\/6-311++G(d,p) level of theory. 1H and 13C   NMR chemical shifts were also calculated with the GIAO method at the   B3LYP\/6-311&#8201;+&#8201;G(2d,p) level of theory. The comparison between   experimental and calculated NMR chemical shift suggests that the   experimental spectra are formed from the superposition spectra of the   two lowest energy conformers of the compound in solution. The most   stable s-cis configuration found in our studies is also the conformation   adopted for a related phenyl cinnamate in solid state. The experimental results were analyzed in terms of the substituent effects.     ","palabras_clave":"13C NMR|1H NMR|4-methylcoumarins|conformations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2972,"idioma_id":4,"titulo":"CHANGES IN FEMALE REPRODUCTION AND BODY CONDITION IN AN  ENDEMIC LIZARD, PHYMATURUS SPECTABILIS, FOLLOWING THE  PUYEHUE VOLCANIC ASHFALL EVENT","resumen":"Puyehue is a largely basaltic stratovolcano located in the southern volcanic zone of the Andes, with an irregular inter-occurrence  intervals  of  eruption  that  affects  the  ecology  of  the  native  communities.    The  latest  Puyehue  eruption occurred in June 2011and dispersed about 100 M tons of pyroclastic materials to the Patagonia steppe of Argentina, due to the West?East predominant winds, affecting an area of over 7.5 M ha.  Herein we report the changes in the reproductive cycle of females  and  body  condition  of  adult  males,  females,  juveniles,  and  newborns  of  Phymaturus  spectabilis,  a  lizard  with  a vulnerable conservation status, following volcanic ash accumulation in Argentinian Patagonian steppe.  This microendemic species inhabits specific volcanic rocky outcrops, in cold and arid environments of Ingeniero Jacobacci, Río Negro, Argentina.  We used the body condition index, an useful method for quantifying the energy reserves of animals, and we studied this index   and the female reproductive cycle during the first (years 2011?2012) and the second (years 2012?2013) activity season post-eruption, and discussed the results in relation to the body condition and the reproductive cycle studied before eruption (years 2006?2011).  We found that only 12% of adult females were reproductive during the first activity season, which indicates that most P. spectabilis, skipped reproduction the year of eruption.  In contrast, during the second activity season 83% of adult   females were reproductive.  However clutch size was changed to one to three offspring, instead of the typical two offspring reported for P. spectabilis before the Puyehue eruption, which is also characteristic of the Phymaturus genus.  In addition, body condition of offspring born during the second activity season was significantly lower than offspring born before the eruption.  We found that body condition of juveniles and adult males was significantly lower during the first activity season than before eruption and significantly higher during the second year.  The lack of improvement in the body condition of non-reproductive females  during  the  first  years  might  explain  the  skip  in  the reproduction  given  that  a  good  body  condition  is  crucial  for   reproduction.    These  results  suggest  that  the  ash  fall  caused  changes  in  the  reproduction  and  the  body  condition  of  a population of a lizard, P. spectabilis, during the first activity season.  However, the population showed rapid recovery during the second activity season post-eruption, indicating heretofore unobserved plasticity in litter size.","palabras_clave":"abdominal palpation|conservation|Patagonia|Puyehue-Cordón Caulle"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2973,"idioma_id":4,"titulo":"A new Late Triassic age for the Puesto Viejo Group (San Rafael depocenter, Argentina): SHRIMP U?Pb zircon dating and biostratigraphic correlations across southern Gondwana","resumen":"The Puesto Viejo Group crops out in the San Rafael Block, southwest Mendoza, at approximately 35&#1048576; S and 68&#1048576;200 W. It consists of the basal mainly grayish Quebrada de los F&#1048576;osiles Formation (QF) overlying by the reddish Río Seco de la Quebrada Formation (RSQ). The basal unit includes both plant remains (pleuromeians and sphenopsids) and vertebrates (scattered &#64257;sh scales, dicynodont synapsids and re-mains of an archosauriform). In contrast, the RSQ beds have yielded only tetrapods, although a more diverse fauna. The latter includes cynodonts as Cynognathus, Pascualognathus and Diademodon, and also dicynodonts (Vinceria and Kannemeyeria). Based on the assemblage of tetrapod taxa the bearing levels were correlated to the Cynognathus AZ of South Africa and thus referred to the Middle Triassic (Anisian). We obtained a SHRIMP 238U\/206Pb age of 235.8 ± 2.0 Ma from a rhyolitic ignimbrite interdigitated be-tween the QF and RSQ formations at the Quebrada de los F&#1048576;osiles section. This new radiometric date for the Puesto Viejo Group suggests that the tetrapod fauna in the RSQ beds existed, instead, during the Late Triassic (early Carnian) some 10 Ma later than the currently accepted age. Two scenarios might explain our results: &#64257;rst, the Cynognathus AZ of South Africa is wrongly assigned to the lower Middle Triassic (Anisan) and should be considered younger in age, Late Triassic (Carnian); second, the relative age of the Cynognathus AZ of South Africa is correct but the inferred range of Cynognathus and Diademodon is incorrect as they were present during the Late Triassic (Carnian) at least in South America. In any case, this new date pose serious doubts about the validity of biostratigraphic correlations based solely on tetrapod taxa, a common practice for Triassic continental successions across Gondwana.","palabras_clave":"Triassic vertebrates and plants|SHRIMP UePb zircon age|Biostratigraphic correlations|South America and South Africa"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2974,"idioma_id":5,"titulo":"Comentario a la Ley 26.967","resumen":"La ley 26.968 prohíbe en todo el país la  venta a menores de edad de pegamentos.    La prohibición alcanza a los  adhesivos, cementos de contacto, selladores o similares que contengan en su  formulación más de un diez por ciento (10%) p\/p (peso en peso) de solventes  orgánicos volátiles susceptibles de ser inhalados para provocar efecto  psicoactivo o estado de alteración mental. ","palabras_clave":"Ley 26.968|Prohibición de pegamentios a menores de edad|Derecho a la salud"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":2978,"idioma_id":4,"titulo":"Randomly-Branched Polymers by Size Exclusion Chromatography with Triple Detection: Computer Simulation Study for Estimating Errors in the Distributions of Molar Masses and Branching Degrees","resumen":"This article theoretically evaluates the biases introduced into the distributions of molar masses (MMD) and number of long chain branches per molecule (LCBD), when randomly-branched polymers are analyzed by size exclusion chromatography (SEC) with molar mass-sensitive detectors. The MMD of a polymer with tetrafunctional branch units was calculated with the Stockmayer equation (1943); and an ideal SEC analysis was simulated that assumes theta-solvent, perfect measurements, and perfect fractionation by hydrodynamic volume except for a minor mixing in the detector cells. In ideal SEC, a negligible bias is introduced into the MMD, with the local dispersity exhibiting a maximum of 1.0035 at the high molar masses. This result is consistent with previous theoretical investigations, but differs qualitatively from experimental observations of polymers containing short- and long-chain branches. When including band broadening in the columns while still assuming perfect measurements, the MMD remains essentially unbiased. In contrast, poor MMD estimates are obtained when the chromatograms are contaminated with additive noise. Only qualitative estimates of the LCBD are possible, due to theoretical limitations combined with propagation of errors in a highly nonlinear calculation procedure.","palabras_clave":"LONG CHAIN BRANCHING|MOLAR MASS DISTRIBUTION|SIZE EXCLUSION CHROMATOGRAPHY|TRIPLE DETECTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3051,"idioma_id":4,"titulo":"Free algebras over a poset in varieties of Lukasiewicz-Moisil algebras","resumen":"A general construction  of the free algebra over a poset  in varieties finitely generated is given in cite{FZ1}. In this paper, we apply this to the varieties of L ukasiewicz--Moisil algebras, giving a detailed description of the free algebra over a  finite poset $(X,leq)$, $mathbf{Free}_{L _n}((X,leq))$. As a consequence of this description, the cardinality of $mathbf{Free}_{L _n}((X,leq))$ is computed for special posets.","palabras_clave":"Algebras libres|Algebras libres sobre un poset|Variedades de álgebras finitamente generadas|Algebras de Lukasiewicz-Moisil"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3052,"idioma_id":4,"titulo":"Cytological analysis of the periodontal pocket in patients with aggressive periodontitis and chronic periodontitis","resumen":"Background: Oral exfoliative cytology includes the study and interpretation of the features cells exfoliated from the oral mucosa.The aim of this study was to analyze cytological changes in the periodontal pocket of patients with different clinical stages ofaggressive periodontitis (AP) and chronic periodontitis (CP). Materials and Methods: Patients aged 24?54 years, of whom 41 werediagnosed with AP, 40 with CP, sub&#8209;classified as mild, moderate and severe periodontitis, and 40 healthy individuals who werethe control group. Samples of the epithelium of the periodontal pocket were taken for the cytological study. Results: Superficialand intermediate cell values were significantly greater in patients with AP than in patients with CP or the control group. Histiocytenumber was higher in patients with CP than in those with AP, and differed significantly in both types of periodontitis compared tothe control group. There were significant differences in polymorphonuclear neutrophil leukocytes when both types of periodontitiswere compared to the control group. Microbial flora was statistically higher in patients with CP, and there were differences betweenpatients with periodontitis and the control group. Conclusions: The cytological study demonstrated that patients with AP hadgreater tissue damage, shown by the increase in intermediate and superficial cells of the epithelium of the periodontal pocketcompared to the group of healthy subjects and to a lesser extent, to patients with CP. Only superficial cells made it possible todifferentiate the sub&#8209;stages of the disease.","palabras_clave":"Exfoliative cytology,|gingivo&#8209;periodontal diseases,|histiocytes|intermediate cells,"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3053,"idioma_id":4,"titulo":"Cacti (Opuntia spp.) as forage in Argentina dry lands: a review","resumen":"Studies on cactus carried out mainly in Mendoza plain, Argentina, and in other country areas were reported. Variations in nutrient contents with three cladode age classes were examined for seven Opuntia forage clones. For all age classes combined, clones showed high organic matter: 84.4%, in vitro organic matter digestibility: 78.9% and low crude protein (CP) content: 4.0%. High doses of fertilizer almost doubled the mean CP content of the cladodes from O. ficus-indica (L.) Mill. x O. lindheimerii Engelm. cross when it was compared with the treatment in which no fertilizer was added (7.8 and 4.3%, respectively).The response to fertilization at the highest application rate was near 4-fold increase over the biomass of the zero fertilization treatment, 3.2 to 12.7 kg DM plant -1 .Of this cross, clone 42 produced a dry matter (DM) biomass of 40 t DM ha -1 in 4 years with a total of 625 mm rainfall which is the greatest DM production recorded to date for such a low rainfall. O. spinulifera Salm-Dyck f. nacuniana Le Houér. appears to be the most promising species for forage production in areas with extremely cold  winters. Clones 46, 80, 83, 89 and 94 had zero frost damage. Economic analysis of Opuntia plantations and the use of cactus for replacing corn in small ruminant diet were included. The cost-benefit relationship of using pre-emergent herbicides on biomass production and fertilizer application on biomass production and protein levels were analyzed. The cactus\/corn cost relationship indicated the possibility of replacing corn by cactus in small ruminant diet.","palabras_clave":"OPUNTIA SPS.|FORAGE PRODUCTIVITY|NUTRIENT CONTENT|COLD HARDINESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3054,"idioma_id":5,"titulo":"Decteccion Precoz de Enfermedad Renal en Adolescentes de un Colegio (IPEM) de la ciudad de Cordoba","resumen":"Introducción: La enfermedad renal crónica (ERC) es  más frecuente en poblaciones con nivel socio económico bajo. El daño renal  precoz se puede evaluar mediante: sedimento urinario, albuminuria en muestra  aislada de orina (MAO), tiras reactivas.           Objetivos: 1 Prevenir y detectar enfermedad renal  (ER) en adolescentes mediante tiras reactivas en MAO. 2 Correlacionar la ER con  factores de riesgo: HTA, diabetes, dislipemia, obesidad, tabaquismo y drogas  nefrotóxicas. 3 Relacionarla con antecedentes familiares.          Materiales y métodos: Estudio observacional,  descriptivo, transversal en 178 alumnos, ambos sexos, &gt;15 años, del Colegio  IPEM N° 250, Córdoba, Argentina. Criterio de exclusión: alumnas en periodo  menstrual o en días previos o posteriores al mismo. Se completó un formulario  incluyendo: sexo, edad, antecedentes personales patológicos (HTA, Diabetes,  dislipemia), antecedentes tóxicos (tabaquismo, drogas ilegales), medicación  habitual, antecedentes familiares, síntomas urinarios, ejercicio físico, falta  de sudoración, pigmentación en el abdomen, sordera y dolores articulares. Se  midió tensión arterial (ClasificacionVIImo informe), peso, talla y  circunferencia abdominal. Se valoró obesidad (IMC y circunferencia abdominal).  Se evaluó proteinuria, hematuria, sedimento urinario, cetonuria, Ph y densidad  . Los datos fueron analizados (Infostat, Test de T, Test correlación de  Pearson).          Resultados: Se incluyeron 49 alumnos, 6 (12.24%)  mujeres y 43 (87.75%) varones. Edad promedio 16.83±1.21 años (R: 15-22).  Tabaquistas 2 (4.08%) varones. Circunferencia abdominal 80.40+10.57 cm (R:  63--108). Peso 63.79+11.97 Kg (R: 46--95). Talla 1.72+0.07m (R: 1.52--1.9). IMC  21.12+3.16 Kg\/m2 (R: 16.03--29.98). TAS 108.65+14.39 mmHg (R: 80--140), TAD  61.35+10.64 mmHg (R: 40--80). 9 tenían preHTA (18.36%), 1 mujer (2.04%), 8  varones (16.32%), 2 varones HTA fase 1 (4.08%), ninguno HTA fase 2. En 10 casos  hubo hipotensión (20.40%), 7 varones (14.28%), 3 mujeres (6.12%). La HTA se  correlacionó con sexo masculino (p&lt; 0.04). Circunferencia abdominal por sexo  &gt;102cm en 3 varones (6.52%), &gt;88 en 1 mujer (16.66%). El 2.04% presentó  fiebre, disuria y coloración alterada de la orina. 44.89% del total tenían  antecedentes familiares. El Ph urinario fue mas alcalino en mujeres (5.6±0.47  vs. 5.66 + 0.4) respectivamente; Densidad promedio 1026±4.65 g\/ml, varones  1027+3.67, mujeres 1023+8.75, mayor en varones (p&lt;0.0008); Hematuria:  varones 0.023+0.15, mujeres 0.16+0.4, en 2 pacientes de 49 (4.08%), 1 varón con  hipotensión arterial e IMC &lt;18, sin antecedentes patológicos. Sedimento:  escaso 87.75%, regular cantidad 12.24%, mas frecuente en mujeres. Aspecto:  límpido 83.67%, ligeramente turbio 12.24%, turbia 4.08%; Proteinuria: varones  0.11+0.47mg\/dl, mujeres 0.06+0.16. Fue significativa (&#8593;300 mg\/dl) en 1 paciente  (2.04%), trazas (&#8595;30 mg\/dl) en 4 (8.16%). Conclusión: La orina turbia y  sedimento patológico es mayor mujeres. El Ph alto, podría corresponder  tubulopatías. La hematuria, poco frecuente, se correlacionó con bajo IMC y  orina alcalina. La proteinuria se presentó en el 12.2%, 5 varones (11.6%) y 1  mujer (16.6%).La HTA fue detectada en dos casos, sexo masculino (p&lt; 0.04).  La población estudiada 4.08% tiene HTA (2 casos) Prehipertensos 18.36% (9  casos). Proteinuria 12.24% (6 casos). La HTA y Prehipertensión no presentaron  alteración urinaria.          &nbsp;          Palabras  claves:screening, HTA, diabetes, obesidad,  tabaquismo, tiras reactivas.","palabras_clave":"Prevencion|Enfermedad renal|Adolescentes|Deteccion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3055,"idioma_id":5,"titulo":"Depósito de corriente piroclástica reciente (1963-64 AD? - 1976 AD?) del volcán Copahue (I): evidencias geológicas de campo y edad radiocarbónica.","resumen":"Se describe un depósito atribuido a una corriente piroclástica sobre los flancos NE, E y SE del volcán Copahue. La datación radiocarbónica (F = 1.3678 ±0.0075) permite asignarle dos edades eruptivas posibles 1963-64 AD y 1976 AD (1961 AD?). Estimamos su importancia en la asignación de peligro volcánico del Copahue.&nbsp;","palabras_clave":"Copahue"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3056,"idioma_id":4,"titulo":"Vanadium and Cancer Treatment: Antitumoral Mechanisms of Three Oxidovanadium(IV) Complexes on a Human Osteosarcoma Cell Line","resumen":"We report herein the antitumor actions of three oxidovanadium(IV) complexes on MG-63 human osteosarcoma cell line. The three complexes: VO(oda), VO(oda)bipy and VO(oda)phen (oda=oxodiacetate), caused a concentration dependent inhibition of cell viability. The antiproliferative action of VO(oda)phen could be observed in the whole range of concentrations (at 2.5 &#956;M), while VO(oda)bipy and VO(oda) showed a decrease of cellviability only at higher concentrations (at 50 and 75&#956;M, respectively) (pb 0.01). Moreover, VO(oda)phen caused a decrease of lysosomal and mitochondrial activities at 2.5 &#956;M, while VO(oda) and VO(oda)bipy affected neutral red uptake and mitochondrial metabolism at 50&#956;M(pb0.01). On the other hand, no DNA damage studied by theComet assay could be observed in MG-63 cells treated with VO(oda) at 2.5\u201310 &#956;M. Nevertheless, VO(oda)phen and VO(oda)bipy induced DNA damage at 2.5 and 10 &#956;M, respectively (p b 0.01). The generation of reactive oxygen species increased at 10 &#956;M of VO(oda)phen and only at 100 &#956;M of VO(oda) and VO(oda)bipy(p b 0.01). Besides, VO(oda)phen and VO(oda)bipy triggered apoptosis as determined by externalization of the phosphatidylserine. The determination of DNA cleavage by agarose gel electrophoresis showed that the ability of VO(oda)(bipy) is similar to that of VO(oda), while VO(oda)(phen) showed the highest nuclease activity in this series. Overall, our results showed a good relationship between the bioactivity of the complexes and their structures since VO(oda)phen presented the most potent antitumor action in human osteosarcoma cells followed by VO(oda)bipy and then by VO(oda) according to the number of intercalating heterocyclic moieties.","palabras_clave":"Oxidovanadium(IV) complexes|Oxodiacetate|Cytotoxicity|Apoptosis|DNA damage|Human osteosarcoma cell line"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3058,"idioma_id":4,"titulo":"Vegetation structure is as important as climate for explaining ecosystem function across Patagonian rangelands","resumen":"SummaryDrylands cover about 41% of Earth's land surface, and 65% of their area supports domestic livestock that depends on the above-ground net primary productivity (ANPP) of natural vegetation. Thus, understanding how biotic and abiotic factors control ANPP and related ecosystem functions can largely help to create more sustainable land-use practices in rangelands, particularly in the context of ongoing global environmental change.We used 311 sites across a broad natural gradient in Patagonian rangelands to evaluate the relative importance of climate (temperature and precipitation) and vegetation structure (grass and shrub cover, species richness) as drivers of ANPP, precipitation-use efficiency (PUE) and precipitation marginal response (PMR).Climatic variables explained 60%, 52% and 12% of the variation in grass cover, shrub cover and species richness, respectively. Shrub cover increased in areas with warmer, drier and winter rainfall climates, while the response observed for both grass cover and species richness was the opposite. Climate and vegetation structure explained 70%, 60% and 29% of the variation in ANPP, PUE and PMR, respectively. These three variables increased with increasing vegetation cover, particularly grass cover. Species richness also increased with ANPP, PUE and PMR. ANPP increased, and PUE decreased with increasing mean annual precipitation, whereas PMR increased with the proportion of precipitation falling in spring?summer. Temperature had a strong negative effect on ANPP and PUE, and a positive direct effect on PMR. Standardized total effects from structural equation modelling showed that vegetation structure and climate had similar strengths as drivers of ecosystem functioning. Grass cover had the highest total effect on ANPP (0.58), PUE (0.55) and PMR (0.41). Among the climatic variables, mean annual precipitation had the strongest total effect on ANPP (0.51) and PUE (&#8722;0.41), and the proportion of the precipitation falling in spring?summer was the most influential on PMR (0.36).Synthesis. Vegetation structure is as important as climate in shaping ecosystem functioning Patagonian rangelands. Maintaining and enhancing vegetation cover and species richness, particularly in grasses, could reduce the adverse effects of climate change on ecosystem functioning in these ecosystems.","palabras_clave":"ABOVE-GROUND NET PRIMARY PRODUCTIVITY|DRYLANDS|ECOSISTEM SERVICES|GRASS-SHRUB BALANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3059,"idioma_id":4,"titulo":"Downregulation of polyphenol oxidase in potato tubers redirects phenylpropanoid metabolism enhancing chlorogenate content and late blight resistance","resumen":"Land plants synthesize phenolic compounds involved in plant defense against invading pathogens through the phenylpropanoid pathway.Although not considered as part of the phenylpropanoid pathway, plant polyphenol oxidases (PPOs) are  enzymes that catalyze cresolase and catecholase reactions on several phenolic compounds. Here,transgenic potato (Solanum tuberosum) tubers with downregulated PPOgenes (-PPO) were challenged with the oomycete pathogen Phytophthora infestans to investigate the interactions between PPO, phenylpropanoid metabolism, and disease resistance. We found that pathogen invasiveness was reduced in -PPO lines, while microscopic evidences suggested that the mechanism underlying the defense response involved the participation of phenolic compounds. Detailed metabolite-profiling analyses demonstrated that the concentration of metabolites related to the phenylpropanoid pathway and chlorogenate in particular was largely altered in PPO-downregulated tubers. Silencing of PPO caused a shift in metabolism from phenylpropanoid precursors to downstream phenylpropanoid products. The presented results suggest that downregulation of PPO redirects the phenylpropanoid metabolism leading to the accumulation of defensive phenolic compounds in the plant cells, consequently enhancing resistance to the pathogen. These results emphasize the importance of components acting in parallel to canonical metabolic pathway constituents  in influencing plant metabolism and reveal new scenarios for modulating the levels of phenolics in crops.","palabras_clave":"chlorogenate|host plant resitance|phenilpropanoids metabolims|solanum tuberosum"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3060,"idioma_id":4,"titulo":"USE OF POLIMERASE CHAIN REACTION TO DETECT HEMOTROPHIC MYCOPLASMA IN  DOG BLOOD. FIRST REPORT IN ARGENTINA","resumen":"Hemotrophic mycoplasma (HM) can infect different mammalian red blood cells. Infected animals suffer anemia when some  conditions (most of them without identification) are present. These epierythrocyte bacteria can be detected by May GrünwaldGiemsa  stained blood smears, but this method have a lot of false positive results. Polimerase chain reaction (PCR) can detect  HM with high sensitivity and specificity. The aim was to use PCR to detect HM in blood of dogs without signs of anemia.  Seventy one dogs that live in homes (6), kennels (25), and breeds (40) were studied. A sample of blood with EDTA was  collected from each dog. DNA was extracted using a rapid extraction DNA kit (DNeasy Blood & Tissue Kit, Qiagen®). A 700  bp region of RNAr16S gene was use to detect HM (HemMycop16S-322s and HemMyco16S-938as primers). Hemotrophic  mycoplasma DNA was detected in 51 samples; 76% of the kennel?s dogs (19\/25), 77% of the breed?s dogs (31\/40) and 33% of  the home?s dogs (2\/6) were infected. Animals with positive PCR result were considered HM infected. The percentage of  infected animals was lower (p<0,05) in home?s dogs than those of kennels and breeds, probably because a lot of animals living  together help HM transmission. As future work, we will extend the study to identify if this is the case. To the best of our  knowledge, this is the first HM study in dog blood using PCR in Argentina.","palabras_clave":"MYCOPLASMA|BLOOD|DOG"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3061,"idioma_id":4,"titulo":"Differences in social anxiety between men and women across 18 countries","resumen":"Sex differences between men and woman in social anxiety are largely unexplored. This study sougth to shed some ligth on thistopic. We administered self-report measures of social anxiety to community samples of 17,672 womwn an 13,440 men from 16 Latin American countries, Spain and Portugal, as well as to a clinical sample of 601 patients diagnosed whith social anxiety disorder. Small but significant defferences were found between mend and woman un the general degree of social anxiety and self -reported fears on interactions with the opposite sex, criticism and embarrassment, and speaking in public-talking to people in authority. These results poin to small, but meaningful differences between men and woman in social anxiety. Implications of these results for the sel-report measurement of social anxiety in men and woman are dicussed.","palabras_clave":"SOCIAL ANXIETY|SOCIAL PHOBIA|SEX DIFFERENCES|AGE DIFFERENCES|CROSS-CULTURAL DIFERRENCES|SAQ-A30"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3062,"idioma_id":4,"titulo":"Use of the Arbuscular Mycorrhizal Fungus Glomus  intraradices as Biological Control Agent of the Nematode  Nacobbus aberrans Parasitizing Tomato","resumen":"The plant-parasitic nematode Nacobbus aberrans is an endoparasite that induces gall formation in the roots and causes severe losses to diverse crops. Some populations of this nematode show preference for certain hosts, revealing the existence of ?races\/groups? with different behaviour and making nematode management difficult. A possible biological control alternative to reduce the damage caused by this species may be the use of arbuscular mycorrhizal fungi (AMF). In the present work, the effect of Glomus intraradices on tomato plants inoculated with the nematode at transplanting and three weeks later was tested. At 60 days, the following parameters were estimated: percentage of AMF colonization, root and aerial dry weight, number of galls and egg masses, and reproductionfactor (RF=final population\/initial population) of N. aberrans. AMF colonization was higher in the presence of the nematode. The use of AMF favoured tomato biomass and reduced the number of galls and RF on the plants inoculated with the nematode at transplanting.","palabras_clave":"arbuscular mycorrhiza|false root-knot nematode|microbiological control|plant protection"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3063,"idioma_id":5,"titulo":"RESULTADOS FÍSICOS Y ECONÓMICOS DE LA IMPLEMENTACIÓN  DE TECNOLOGÍAS CRÍTICAS EN SISTEMAS GANADEROS BOVINOS DE CRÍA Y CICLO COMPLETO EN CUENCA DEL SALADO, PROVINCIA DE BUENOS AIRES","resumen":"En el marco del Proyecto ?Impacto Económico de la implementación de tecnologías críticas en producciones seleccionadas del sector agropecuario?, surge el presente trabajo, realizado en Cuenca del Salado provincia de Buenos Aires; donde la producción de carne bovina y sus indicadores de productividad están lejos de aquellos potenciales y han permanecido estancados por décadas. Existen tecnologías, claramente superadoras de las empleadas por una fracción importante de productores, pero no son adoptadas o lo son parcialmente, sin aprovechar su potencial. La hipótesis es que la adopción de las tecnologías críticas genera un impacto económico positivo, que se visualiza en los resultados  de las producciones de carne en los sistemas de cría y ciclo completo. Este  impacto obtenido con la adopción de TC agrupadas por afinidad temática es diferente si son aplicadas de manera individual o secuencial.  El objetivo de este trabajo fue conocer los resultados físicos y económicos de la adopción de tecnologías críticas en los  niveles de producción bajo, medio y alto, en sistemas ganaderos. Se deberían considerar a las TC que integran manejo nutricional en primer lugar en el proceso de adopción, debido a sus buenos resultados y que la implementación de estas tecnologías tiene bajo costo.","palabras_clave":"MODELOS GANADEROS|INDICADORES|NIVEL TECNOLOGICO|ADOPCIÓN|AFINIDAD TEMATICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3150,"idioma_id":4,"titulo":"Acclimating to thermal changes: intraspecific variation by a small mammal from the Andes Mountains","resumen":"Ambient temperature strongly affects an ecosystem?s characteristics as well as the attributes of individuals, eventually determining the distribution of populations and species. Phenotypic plasticity plays a central role in the administration of energy under thermal variation through traits underlying energy acquisition and expenditure. A powerful approach to assess acclimation ability to environmental variation is studying relevant traits along natural geographic gradients. Our goal was to assess and quantify in the small rodent Phyllotis xanthopygus, changes in traits relevant to energy balance in response to itsthermal landscape. We compared energy intake and digestibility by animals from sites at different elevations under different temperatures in the laboratory. Results showed an increase in energy acquisition rates by the lower-elevation individuals to cope with low temperatures, while high-elevation animals appeared unaffected by this treatment. After acclimating to warmer conditions, all individuals showed a similar decrease in energy intake, irrespective of their origin site. We also assessed thermal conductance in individuals from different elevations and found that animals from higher sites exhibited lower heatloss rates. Our evidence suggests that heat conservation differences could in part account for differences among high and low elevation animals in the ability to cope with low temperatures. The lack of plasticity under the warm thermal treatment conforms to recent reports of high conservatism on the upper limit of the thermoneutral zone. P. xanthopygus displays intraspecific variation in the response to temperature, and we propose that this is highly relevant to model its chances in a warming environment.","palabras_clave":"THERMAL LANDSCAPE|ELEVATION CLINE|ENERGY BALANCE|PHENOTIPIC VARIATION|SMALL MAMMALS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3152,"idioma_id":5,"titulo":"PANORAMA SOCIAL, POLÍTICO Y ECONÓMICO DE AMÉRICA LATINA Y EL CARIBE: el desafío de la convergencia y la unidad","resumen":"Como hemos analizado en los Anuarios anteriores, América Latina ha sido una de las pocas regiones del mundo que ha mantenido signos de crecimiento económico en los últimos años a pesar de la situación de crisis financiera y económica internacional. Esta realidad ha impactado directamente en avances sociales y fundamentalmente en la reducción de la pobreza y la marginalidad, dando lugar al surgimiento de nuevos sectores de clase media en varios de los países de la región. Sin perjuicio de esta realidad, el gran desafío que enfrentan los gobiernos latinoamericanos es consolidar estos avances con políticas públicas de inclusión, que favorezcan la igualdad y por ende la mejor distribución de ese crecimiento. Sin perjuicio de ello, América Latina sigue siendo el continente más desigual del planeta. En la región la cuestión de la pobreza está centrada en el tema de la desigualdad. De manera tal que para entender el problema estructural de América Latina es necesario analizar la cuestión de la desigualdad más que de la pobreza, lo cual nos enfrenta inmediatamente a la idea de repensar las políticas públicas de desarrollo.En este sentido, es importante mencionar que América Latina tiene una presión tributaria muy escasa, para dar algunos ejemplos, en el caso de Brasil es del 35 %, Argentina de un 30 %, Uruguay tiene un 28 %, Paraguay un 10 % y Guatemala menos del 10%. Esta situación repercute en el escaso poder de maniobra que tienen los Estados para desarrollar políticas de inclusión de largo alcance. Por otro lado, los sistemas educativos ?que antes se presentaban como una herramienta de integración de las clases sociales- tienden a dejar de serlo. Por ello los Estados van perdiendo los controles y el poder de recaudación para lograr una mejor redistribución de la riqueza. En este sentido son Estados ausentes.","palabras_clave":"América Latina|panorama social|económico|político"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3153,"idioma_id":4,"titulo":"Triatominae in furnariid nests in the Argentine Gran Chaco","resumen":"Triatomines (Hemiptera, Reduviidae) are bloodsucking insects involved in the transmission of Trypanosoma cruzi, the causative agent of Chagas disease, an important public health problem in Latin America. The triatomine species found in sylvatic habitats generally play a limited epidemiological role compared to domestic species, but they may act as a reinfestation source of dwellings after insecticide spraying and have to be carefully considered in control strategies of Chagas disease transmission. The objectives of this work were to carry out a survey of the sylvatic triatomine species colonizing Furnariidae nests in a typical area of the Chaco region of Argentina during the winter and to study the parasites and natural enemies associated with the collected triatomines. Sixty-three triatomine specimens were collected from Furnariidae nests (Coryphistera alaudina and Phacellodomus sibilatrix) randomly selected within the study area. Fifty-four were identified as Psammolestes coreodes, seven as Triatoma platensis, and two as Triatoma infestans. Specimens of T. infestans and T. platensis were found in one nest. The first finding of instar nymphs of T. infestans x T. platensis in a sylvatic habitat is reported. For the first time, sylvatic collected specimens of T. platensis were found infected by T. cruzi. Triatoma virus was found in one Ps. coreodes specimen.","palabras_clave":"CHAGAS|NIDOS DE FURNARIDOS|TRIATOMA INFESTANS |TRIATOMINOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3154,"idioma_id":4,"titulo":"Modelling the change in the oxidation coefficient during the aerobic degradation of phenol by acclimated activated sludge","resumen":"In this work the aerobic degradation of phenol by acclimated activated sludge was studied. Results demonstrate that while the phenol removal rate by acclimated activated sludge follows the Monod model, the oxygen uptake rate obeys a Haldane-type equation. The phenol oxidation coefficient obtained at different intial phenol concentrations ranged from 1.9 to 2.6 mol O2 &#8729; mol-1 phenol. A mathematical model based on a simplified version of the catalytic mechanism of the enzyme phenol 2-monooxygenase was developed to predict transient phenol concentrations and oxygen requirements by phenol-acclimated activated sludge in batch reactors under different initial phenol concentrations. The proposed model not only adequately represents the experimental results of the present paper, but also those reported by other authors. Particular cases of the proposed model are discussed.","palabras_clave":"OXYGEN UPTAKE RATE|PHENOL|BIOKINETIC MODEL|RESPIROMETRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3155,"idioma_id":4,"titulo":"Influence of technological variables on the functionality of the cell-free supernantant of fermented buttermilk","resumen":"Among functional foods, fermented milks containing probiotic bacteria dominates the global market (Saxelin, 2008; Figueroa-González et al. 2011). In these products, functionality is given by a combination of their bioactive components such as viable probiotic bacteria and lactic acid starters, peptides derived from milk fermentation and other components such as exopolysaccharides or products derived from lactic acid bacteria metabolism in milk (bacteriocins, organic acids, for example) (Vinderola et al. 2008). Cell viability of probiotic bacteria along production and storage of probiotic foods is a prerequisite in order to achieve their claimed health benefits (Ouwehand and Salminen 1998; Galdeano and Perdigón 2004). Many other foods, other than fermented milks or fresh cheeses are not, up to now, suitable vehicles for incorporating probiotic bacteria, since their process of manufacture (high temperature) or storage (room temperature) or their physicochemical characteristics (too acid, too low water activity, too high osmotic pressure) render them inadequate to carry viable microorganisms. During milk fermentation, a range of secondary metabolites (bacteriocins, exopolysaccharides) are produced by lactic acid bacteria or release by them from milk proteins, such as bioactive peptides (Vinderola et al. 2008). Many of these components have been associated with health promoting properties such as&nbsp; mucosal immunomodulation, antihypertensive, antithrombotic, opioid and antimicrobial activities and participation in many nutritional pathways (Silva and Malcata 2005). Buttermilk is a low-cost by-product of the dairy industry obtained during butter manufacturing. In a previous study (Burns et al. 2008), we reported the capacity of buttermilk to support the growth of lactobacilli. Although the nutritional and functional value of skim milk components is well understood, buttermilk has only recently gained attention as a potential source of functional ingredients, and the production of buttermilk fractions as value added ingredients would have a great economic impact (Corredig et al. 2004). In a following work, (Burns et al., 2010), we showed that buttermilk was a suitable substrate for the fermentation with a proteolytic strain of Lactobacillus and for the release of peptide fractions able to be spray-driedand to modulate the gut mucosa in vivo. The final goal of this series of works is to obtain, by spray-drying, the bioactive compounds released by an authoctonous strain of Lactobacillusin buttermilk, to confer functionality to some foods not always able to carry viable probiotic bacteria, such as cereal bars, cookies or too-acidic drinks.Taking into account that many technological variables might influence the functionality of food (Vinderola et al. 2011), the aim of this work was to determine the influence of the degree of proteolysis of buttermilk proteins on the functionality of fermented buttermilk. Different degrees of proteolysis were achieved by using different substrate concentration and pH-controlling agents.","palabras_clave":"Functionality|Fermented buttermilk|Cell-free fraction|IgA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3156,"idioma_id":4,"titulo":"Curcumin ameliorates autoimmune diabetes. Evidences in accelerated murine models of type 1 diabetes","resumen":"Type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease that selectively destroys pancreatic &#946; cells. The only possible cure for T1DM is to control autoimmunity against &#946; cell-specific antigens. We explored whether the natural compound curcumin, with anti-oxidant and anti-inflammatory activities, might down-regulate the T cell response that destroys pancreatic &#946; cells to improve disease outcome in autoimmune diabetes. We employed two accelerated autoimmune diabetes models: (i) cyclophosphamide (CYP) administration to non-obese diabetic (NOD) mice and (ii) adoptive transfer of diabetogenic splenocytes into NODscid mice. Curcumin treatment led to significant delay of disease onset, and in some instances prevented autoimmune diabetes by inhibiting pancreatic leucocyte infiltration and preserving insulin-expressing cells. To investigate the mechanisms of protection we studied the effect of curcumin on key immune cell populations involved in the pathogenesis of the disease. Curcumin modulates the T lymphocyte response impairing proliferation and interferon (IFN)-&#947; production through modulation of T-box expressed in T cells (T-bet), a key transcription factor for proinflammatory T helper type 1 (Th1) lymphocyte differentiation, both at the transcriptional and translational levels. Also, curcumin reduces nuclear factor (NF)-&#954;B activation in T cell receptor (TCR)-stimulated NOD lymphocytes. In addition, curcumin impairs the T cell stimulatory function of dendritic cells with reduced secretion of proinflammatory cytokines and nitric oxide (NO) and low surface expression of co-stimulatory molecules, leading to an overall diminished antigen-presenting cell activity. These in-vitro effects correlated with ex-vivo analysis of cells obtained from curcumin-treated mice during the course of autoimmune diabetes. These findings reveal an effective therapeutic effect of curcumin in autoimmune diabetes by its actions on key immune cells responsible for &#946; cell death.","palabras_clave":"NOD mouse|T lymphocytes|T-bet|dendritic cells"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3157,"idioma_id":4,"titulo":"First characterisation of a CPD-Class I photolyase from an UV-resistant extremophile isolated from High-Altitude Andean Lakes","resumen":"UV-resistant Acinetobacter  sp. Ver3 isolated from  High-Altitude Andean Lakes (HAAL) in Argentinean Puna, one of the highest UV exposed ecosystems on Earth, showed e&#64259;cient DNA photorepairing  ability, coupled  to highly e&#64259;cient antioxidant enzyme activities in response to   UV-B stress. We herein present the cloning, expression, and functional characterization of a cyclobutane pyrimidine dimer (CPD)-class I  photolyase (Ver3Phr) from  this extremophile  to  prove its involvement  in the previously noted  survival capability. Spectroscopy of the overexpressed and puri&#64257;ed protein identi&#64257;ed &#64258;avin adenine   dinucleotide (FAD) and 5,10-methenyltetrahydrofolate (MTHF) as chromophore and antenna molecules, respectively.   All functional analyses were performed in parallel with the ortholog  E. coli photolyase. Whereas the E. coli enzyme showed the FAD chromophore as a mixture of oxidised and reduced states, the Ver3 chromo- phore always remained partly (including the semiquinone state) or fully reduced under all experimental conditions  tested. Functional complementation of Ver3Phr in PhrRecA E. coli strains was assessed by traditional UFC counting  and measurement of DNA bipyrimidine  photoproducts by   HPLC coupled with electrospray ionisation-tandem mass spectrometry  (ESI-MS\/MS) detection.  The results identi&#64257;ed strong photoreactivation ability in vivo of Ver3Phr while its nonphotoreactivation function, probably   related with the stimulation  of nucleotide  excision repair (NER), was not as manifest as for EcPhr. Whether this is a question of the approach using an exogenous photolyase incorporated in a non-genuine  host or a fundamental di&#64256;erent behaviour of a novel enzyme from an exotic environment will need further studies.","palabras_clave":"UV-RESISTANT|ACINETOBACTER|PHOTOLYASES|FAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3158,"idioma_id":4,"titulo":"- Isotopic evidence on human bone for declining maize consumption during the Little Ice Age in central western Argentina.","resumen":"This paper explores variation in maize consumption among human societies in arid environments of central-western Argentina over the last 2500 years. Increasingly positive human d13C signatures suggest a high intake of C4 resources (maize) until ca. A.D. 1400. After this time, the importance of maize in the diet drops and never reaches pre-Hispanic consumption rates, despite the known importance of maize to Inka and other late-prehistoric societies in the region. This decline appears to be related to coldertemperatures during the Little Ice Age from the beginning of the 15th to the mid19th centuries.","palabras_clave":"Maize|Stable isotopes|Late Holocene"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3159,"idioma_id":5,"titulo":"Leucoencefalomalacia equina: descripción de tres brotes asociados a intoxicación por fumonisinas, en Provincia de Buenos Aires, Argentina.","resumen":"Se describen tres brotes de leucoencefalomalacia equina (LEME) ocurridos en tres partidos de la Pcia de Bs. As., Argentina durante el año 2011. El diagnóstico presuntivo de LEME se realizó sobre la base de los datos epidemiológicos, la historia clínica y los hallazgos anatomopatólogicos. En todos los casos, se identificaron a la necropsia áreas de color amarillento o de franca licuefacción en la sustancia blanca del encéfalo. El estudio histopatológico reveló distintos grados de  hemorragia y marcado edema del neuropilo, disgregación del tejido con necrosis neuronal e irregular presencia de células de la microglía. Mediante test de ELISA de competición se identificaron niveles superiores a 10 ppm de fumonisinas en los alimentos consumidos por los animales. Este hallazgo permitió asociar la leucoencefalomalacia con la fumonisina como agente tóxico causal.","palabras_clave":"EQUINO|LEUCOENCEFALOMALACIA|FUMONISINA|EPIDEMIOLOGÍA|PATOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3160,"idioma_id":4,"titulo":"Humoral response and evolution of Echinococcus infection in experimentally infected sheep","resumen":"There is little information on the humoral response of sheep experimentally infected with Echinococcus granulosus. Thus, the objective of this study was to evaluate this response and measure its evolution. Doses of 10, 100, 1000 and 10000 E. granulosus eggs were prepared and inoculated via intraruminal puncture. Blood samples were obtained before inoculation and every 48 h after inoculation, until they became seropositive. Thereafter, they were taken monthly for the first year and then every three months until 1700 days of observation had been completed. An ELISA test, with total hydatid fluid antigen, was used for immunodiagnosis. The average optical density of the 12 inoculated sheep was found to be above the mean cutoff value 10 days after inoculation, went on increasing until 180 days after inoculation and remained above the cutoff level until the end of the observation period. This confirms that the antibody response of sheep to E. granulosus infection occurs before production of hydatid fluid and that activation, mobilization and establishment of oncospheres in the tissues generates a persistent response from the host's immune system.","palabras_clave":"ECHINOCOCCOSIS|HUMORAL RESPONSE|SHEEP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3161,"idioma_id":4,"titulo":"Diversity of leafhoppers (Hemiptera: Cicadellidae) in experimental rice lots and associated weeds in Buenos Aires province, Argentina , a,c, María E. Brentassia, Graciela Varelaa, Gime","resumen":"We identified the species of Cicadellidae associated with rice fields from an agricultural experimental station of LaPlata city, Argentina, and explored the diversity pattern of the leafhopper assemblage. Insects were obtained fromrice and surrounding weeds between 2006 and 2010. Syncharina argentina (Berg) and Agalliana ensigera Omanwere the most abundant species in rice and weeds, respectively. Diversity (H&#8242;), heterogeneity (D) and evenness (J)indices were estimated. There was a significant effect of crop cycle (2006 to 2010) and host plant (rice and weeds)on H&#8242; and D, with the interaction between them being not significant. Evenness was similar in rice lots and weeds,but differed between crop cycles. The pattern of abundance of species within rice lots and weeds followed thelogarithmic model. Possible explanations for this pattern are discussed. The importance of the presence of somespecies as vectors of plant pathogens is highlighted.","palabras_clave":"leafhoppers|rice field|biodiversity|range-abundance models|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3163,"idioma_id":4,"titulo":"Effect of the helicity injection rate and the Lundquist number on spheromak sustainment","resumen":"The dynamics of the magnetic relaxation process during the sustainment of spheromak configurations at different helicity injection rates is studied. The three-dimensional activity is recovered using time-dependent resistive magnetohydrodynamic simulations. A cylindrical flux conserver with concentric electrodes   is used to model configurations driven by a magnetized coaxial gun.   Magnetic helicity is injected by tangential boundary flows. Different   regimes of sustainment are identified and characterized in terms of the   safety factor profile. The spatial and temporal behavior of fluctuations   is described. The dynamo action is shown to be in close agreement with   existing experimental data. These results are relevant to the design and   operation of helicity injected devices, as well as to basic   understanding of the plasma relaxation mechanism in quasi-steady state.","palabras_clave":"SPHEROMAKS|HELICITY INJECTION|TOROIDAL PLASMA CONFINEMENT|ELECTRIC FIELDS|ELECTRODES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3164,"idioma_id":4,"titulo":"The salinity signature of the cross-shelf exchanges in the Southwestern Atlantic Ocean: Satellite observations","resumen":"Satellite-derived sea surface salinity (SSS) data from Aquarius and SMOS are used to study theshelf-open ocean exchanges in the western South Atlantic near 35S. Away from the tropics, theseexchanges cause the largest SSS variability throughout the South Atlantic. The data reveal a well-definedseasonal pattern of SSS during the analyzed period and of the location of the export of low-salinity shelfwaters. In spring and summer, low-salinity waters over the shelf expand offshore and are transferred to theopen ocean primarily southeast of the river mouth (from 36S to 37300S). In contrast, in fall and winter,low-salinity waters extend along a coastal plume and the export path to the open ocean distributes alongthe offshore edge of the plume. The strong seasonal SSS pattern is modulated by the seasonality of thealong-shelf component of the wind stress over the shelf. However, the combined analysis of SSS, satellitederivedsea surface elevation and surface velocity data suggest that the precise location of the export ofshelf waters depends on offshore circulation patterns, such as the location of the Brazil Malvinas Confluenceand mesoscale eddies and meanders of the Brazil Current. The satellite data indicate that in summer, mixturesof low-salinity shelf waters are swiftly driven toward the ocean interior along the axis of the Brazil\/MalvinasConfluence. In winter, episodic wind reversals force the low-salinity coastal plume offshore wherethey mix with tropical waters within the Brazil Current and create a warmer variety of low-salinity waters inthe open ocean.","palabras_clave":"Cross-shelf exchanges|Southwestern Atlantic Shelf|Sea Surface Salinity|Observations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3166,"idioma_id":4,"titulo":"Influence of the hydration by the environmental humidity on the metallic speciation and the photocatalytic activity of Cr\/MCM-41","resumen":"The influence of the environmental humidity on the Cr species deposited on inorganic supports like MCM-41 silicates was analyzed by UVvis Diffuse Reflectance (UVvis RD), Electronic Spin Resonance (ESR) and X-ray near-edge (XANES) spectroscopy. Metal speciation could be inferred, finding that prolonged exposure periods under environmental humidity provoked the reduction of the active Cr6 species and thus, the decrease of the Cr\/MCM-41 photoactivity. After the Ti loading over the Cr modified samples, Cr species and the photoactivity were not notably influenced by the humidity exposure. Thus, it could be concluded that the presence of Ti is important because the TiO2 cover protects the oxidized Cr species, stabilizing them.","palabras_clave":"PHOTOACTIVITY|MCM-41|CHROMIUM SPECIES|HUMEDAD AMBIENTE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3167,"idioma_id":4,"titulo":"Crystallographic and kinetic study of riboflavin synthase from Brucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility (ARTICULO DESTACADO COMO TAPA DE REVISTA)","resumen":"Riboflavin synthase (RS) catalyzes the last step of riboflavin biosynthesis in microorganisms and plants, which corresponds to the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine to yield one molecule of riboflavin and one molecule of 5-amino-6-ribitylamino-, 4(1H,3H)-pyrimidinedione. Owing to the absence of this enzyme in animals and the fact that most pathogenic bacteria show a strict dependence on riboflavin biosynthesis, RS has been proposed as a potential target for antimicrobial drug development. Eubacterial, fungal and plant RSs assemble&nbsp; as homotrimers lacking C3 symmetry. Each monomer can bind two substrate molecules, yet there is only one active site for the whole enzyme, which is located at the interface between two neighbouring chains. This work reports the crystallographic structure of RS from the pathogenic bacterium Brucella abortus (the aetiological agent of the disease brucellosis) in its apo form, in complex with riboflavin and in complex with two different product analogues, being the first time that the structure of an intact RS trimer with bound ligands has been solved. These crystal models support the hypothesis of enhanced flexibility in the particle and also highlight the role of the ligands in assembling the unique active site. Kinetic and binding studies were also performed to&nbsp; complement these findings. The structural and biochemical information generated may be useful for the rational design of novel RS inhibitors with antimicrobial activity.","palabras_clave":"riboflavin|riboflavin synthase|Brucella|chemotherapeutic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3168,"idioma_id":4,"titulo":"Theoretical Analysis of Nitroxide-Mediated Copolymerization of Styrene and &#945;-Methyl-Styrene under Different Operating Policies and Reactor Designs","resumen":"          The polymerization that IUPAC terms reversible-deactivation  radical polymerization is a controlled radical polymerization technique (CRP)  that offers the possibility of producing polymers with tailored properties  without the stringent restrictions required in ionic polymerization. In this  work we present a theoretical analysis of the influence of operating and design  conditions on the final product properties for the nitroxide-mediated  copolymerization (NMP) of styrene (St) and &#945;-methyl styrene (AMS). Several  reactor configurations are analyzed (batch, semibatch, and tubular with and  without side feeds) along with changes in feeding policy and temperature  profile. For this purpose a mathematical model is developed to predict  copolymer average properties and the complete bivariate MWD. The results  obtained are very helpful in establishing design parameters and optimal  operating policies according to the desired copolymer microstructure and they  underline the importance of simulation as a powerful tool in process  optimization.   ","palabras_clave":"copolymerization|modeling|molecular weight distribution|nitroxide mediated polymerization|pgf"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3170,"idioma_id":5,"titulo":"Normas de categorización, organización y funcionamiento de las Unidades de Cuidados Intensivos e Intermedios Pediátricos en los establecimientos asistenciales Parte II: Unidad de Cuidados Intensivos Pediátricos Nivel 2 - Unidad de Reanimación - Unidad de","resumen":"El primer objetivo de la presente norma es mejorar la organización y el funcionamiento de los Servicios o Unidades de Terapia Intensiva Pediátrica (UTIP),1  más comunmente denominados de Cuidados Intensivos Pediátricos (UCIP), a fin de lograr estándares mínimos de calidad que permitan un cuidado efectivo de los pacientes pediátricos críticamente enfermos y una disminución de la morbilidad y la mortalidad. El segundo objetivo es presentar una propuesta para la categorización de las UCIP.","palabras_clave":"Terapia Intensiva|Pediatría|Medicina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3174,"idioma_id":4,"titulo":"Trajectory-tracking controller design with constraints in the control signals: a case study in mobile robots","resumen":"This paper is a continuation of a previous work of authors, Scaglia et al. [G. J. E. Scaglia, L.M. Quintero, V. Mut and F. Di Sciascio, ?Numerical methods based controller design for mobilerobots,? Robotica 27(2), 269?279 (2009)]. A method is presented to choose the controller parameterssuch that, the values of the control actions do not exceed the maximum allowable and the trackingerrors tend to zero. In addition, the analysis of the controller design parameters is included. Theexperimental results (laboratory experiments and a real world application) demonstrate the efficiencyof the controller.","palabras_clave":"Control System Design|Nonlinear Model|Tracking Trajectory Control|Mobile Robots"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3206,"idioma_id":4,"titulo":"Early to Middle Holocene transition in the Pastos Chicos record, dry Puna of Argentina","resumen":"This paper presents a multi-proxy record and its paleoenvironmental interpretation from Pastos Chicos (23 400 2900 S; 66 250 3200 W; 3781 m asl), Susques, Jujuy province, Argentina. The analysis includes a study of fluvial sediments and geomorphology, and the contained diatoms and pollen record at centenary resolution. Two main environmental phases characterize the w9000e4200 BP interval. The first phase was a humid period between w9000 and 7300 BP (circa 10,000e8100 cal. BP) which showed organic soils formation in a floodplain broadly vegetated by grasses with a high and stable water table level. The second phase developed between 7300 and 6000 BP (w8100e6800 cal. BP) and showed a moderately drier environment interrupted by punctuated humid events such as those around 7000 and 6300 BP. This environment could be interpreted as a permanently existing meandering river with a floodplain with shallow oxbow lakes, bordered by a diverse shrub steppe. After 6000 BP, the fluvial system turned into a braided river situated in a sandy floodplain with dunes and ephemeral ponds. At the end of the sequence (i.e. post w4200 BP), salt crusts developed and the river lowered its base level by 8 m. These results seem to show that the Pastos Chicos river basin evolved from low energy and more humid conditions established during the Early and the first part of the Middle Holocene, to drier ones in a system with more energy during some events of the second part of the latter period. The start of this aridization process at w6000 BP in the basin, seems to be substantially later than other observations in local records of the Andean area. This could be due to physiographic control of the moisture by the catchment area (w1000 km2) that generates a catchment-averaged regional scale signal of smaller amplitude, which is delayed for individual tributaries. These studies, with other ongoing analysis, will improve the accuracy of the models of resource structure in the area in several spaceetime scales and, consequently, advance knowledge concerning the organizational pattern of human societies in the past.","palabras_clave":"Paleoecología|Palinologia|Puna"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3260,"idioma_id":4,"titulo":"Balancing agricultural and hydrological risk in farming systems of the Chaco plains.","resumen":"Like in other semiarid areas of the world, farming systems in semiarid Chaco tend to use water-conservative crop systems to minimize production risks associated to water stress. While this strategy aims to stabilize crop yields and farmers income, the underutilization of water resources in wet years may result in heavy deep drainage water losses which could potentially lead to the development of dryland salinity. Conversely, more intensive crop systems that consume water exhaustively present lower drainage rates but are more prone to crop failure. We employed a monthly soil water balance approach to analyze the productive and ecohydrologic effects of five different farming systems across the region (winter, spring, summer, late-summer and a winter?summer double crop system) and to assess the possibility of minimizing emerging trade-offs between them through flexible water-informed cropping sequences. Our results indicate that water stress diminishes as crop systems are delayed towards the rainy season (winter > spring > summer > late-summer), but the productively safer late-summer strategy is the one with highest drainage rates. In most of the region, the relatively high production risk and insignificant drainage probability generally determine the convenience of conservative late-summer systems. However, in areas (or years) with higher amount and\/or seasonality of rainfall, more intensive double-crop systems are necessary to minimize the likely high drainage fluxes. As rainfall is highly variable from one year to the other, the knowledge of soil water content at the onset of the season is useful to predict part of the available water offer and to asses expected production and ecohydrologic risks. In the most drainage-prone areas the implementation of flexible sequences that alternate conservative and intensive crop systems depending on soil water status, significantly reduced mean annual drainage with an acceptable increase in mean water stress index.","palabras_clave":"Semiarid Chaco|Agriculture|Water Stress|Deep Drainage"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3262,"idioma_id":4,"titulo":"Shiga Toxins and stx-phages: highly variable entities","resumen":"Shiga toxins are the main virulence factors of a group of Escherichia coli strains (STEC) that cause severe human diseases such as haemorrhagic colitis and haemolytic uraemic syndrome. The Shiga toxin family comprises several toxin subtypes, which have been differentially related to clinical manifestations. In addition, the phages that carry the Shiga toxin genes (stx-phages) are also diverse. These phages play an important role not only in the dissemination of Shiga-toxin genes and the emergence of new STEC strains, but also in the regulation of Shiga toxin production. Consequently, differences in stx-phages may affect the dissemination of stx genes as well as the virulence of STEC strains. In addition to presenting an overview of Shiga toxins and stx-phages, in this review we highlight current knowledge about the diversity of stx-phages, with emphasis on its impact on STEC virulence. We consider that this diversity should be taken into account when developing STEC infection treatments and diagnostic approaches, and when conducting STEC control in reservoirs. ","palabras_clave":"Shiga toxin|phages|subtypes|diversity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3263,"idioma_id":5,"titulo":"Primer registro de Eumops bonariensis (Chiroptera, Molossidae) para la provincia de Corrientes, Argentina: implicancias para la conservación de la biodiversidad del Paraje Tres Cerros.","resumen":"Se presenta el primer registro de Eumops bonariensis (Chiroptera, Molossidae) para la provincia de Corrientes, Argentina. Se capturó un macho adulto con red de neblina en el cerro ?Capará?, ubicado en la Estancia Las Marías, Paraje Tres Cerros, Departamento General San Martín. Con esta adición esta provincia incrementa la riqueza específica de quirópteros a 29 especies.","palabras_clave":"MOLOSO|MESOPOTAMIA|DISTRIBUCIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3264,"idioma_id":4,"titulo":"A bottom-up building process of nanostructured La0.75Sr0.25Cr0.5Mn0.5O3\u0001d electrodes for symmetrical-solid oxide fuel cell: Synthesis, characterization and electrocatalytic testing","resumen":"Pure-phase La0.75Sr0.25Cr0.5Mn0.5O3d (LSCM) nanocrystallites have been successfully synthesized by the","palabras_clave":"PEROVSKITE OXIDE|COMBUSTION METHOD|NANOCRYSTALLITES|NANOELECTRODES|SYMMETRICAL CELLS|SOLID OXIDE FUEL CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3265,"idioma_id":4,"titulo":"Effect of storage conditions and antioxidants on the oxidative stability  of sunflower-chia oil blends","resumen":"The mixture of different proportions of sunflower with chia oil provides a simple method to prepare edible oils with a wide range of desired fatty acid composition. Sunflower-chia (90:10 and 80:20 wt\/wt) oil blends with the addition of rosemary (ROS), ascorbyl palmitate (AP) and their blends (AP:ROS) were formulated to evaluate the oxidative stability during storage at two temperature levels normally used, cooling (4±1 °C) and room temperature (20±2 °C) for a period of 360 days. Peroxide values (PV) of the oil blends with antioxidants stored at 4±1 ºC showed levels &#8804; 10.0 meq O2\/kg oil; the lowest levels of PV were found for blends with AP:ROS. Values higher than 10.0 meq O2\/kg were observed between 120-240 days for oil blends stored at 20±2 ºC. Similar trends were observed with p-anisidine and Totox values. The oxidative stability determined by the Rancimat method and differential scanning calorimetry (DSC) showed a greater susceptibility of the oils to oxidative deterioration with increasing unsaturated fatty acids content. The addition of antioxidants increased the induction time and kinetic parameters for all the oil blends. Temperature had a strong influence on the stability of these blends during storage.","palabras_clave":"OIL BLENDS|OXIDATIVE STABILITY|STORAGE CONDITIONS|DIFFERENTIAL SCANNING CALORIMETRY|RANCIMAT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3266,"idioma_id":4,"titulo":"Effect of conventional and no-till practices on solute transport in long term field trials using undisturbed soil columns","resumen":"The prediction and description of water and solute movement in soils under different tillage systems is essential to the study of pesticide contamination in soils and groundwater quality. However, the impact of tillage practices in soil physical characteristics varies across locations and types of soil. In this work we analyzed the long-term impact of no till (NT) and conventional tillage (CT) on solute transport within three different Argentinian soils. Bromide transport studies were conducted under controlled conditions in the laboratory using undisturbed soil columns. Samples were taken from long term field trials, with a history of over 16 years of NT and CT practices. The studied soils were: Parana´ soil (PAR), a silty clay loam soil (<37% clay), and Mandfredi (MAN) and Pergamino (PER), both silty loam soils ( <26% clay). Breakthrough curves were fitted using the non-equilibrium equation model (CDEneq). The following transport parameters were estimated from the fitted curves: velocity (v), hydrodynamic dispersion coefficient (D), dispersivity ( l), mobile water content ( b), and mass transfer coefficient ( v). The relationship between the estimated parameters and soil properties was analyzed. Also, the parameters were compared between soils and tillage practices using a mixed linear model. Parameters v and D were positively correlated to soil clay content in NT samples. Such correlation was not observed in CT samples. This would suggest that clay content in soils under conservational tillage, favors the transport of solutes, as it increases v and D. In this study, no differences were found between soils or tillage practice regarding the estimated v parameter. Differences were found for D and l between CT and NT samples in PARsoil. In this case, the magnitude of solute dispersion was higher in the NT samples. For the other soils (MAN and PER), no difference in D and l between tillage practices was found. Effects of tillage on solute transport was not substantial in these soils, even when no till management had been applied for over 30 years. Whereas in PAR (the soil with higher clay content), soil management had an important effect on structure, and therefore on solute and water transport. These results suggest that in the PAR clayey soils studied, structure is well preserved under conservational tillage, and this could lead to an increase in the risk of leaching of solutes or chemical substances.","palabras_clave":"Tillage  |Solute transport|Soil structure"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3267,"idioma_id":5,"titulo":"Genotyping Mycobacterium bovis from cattle in the Central Pampas of Argentina: temporal and regional trends","resumen":"Mycobacterium bovis is the causative agent of bovine tuberculosis (TB), a disease that affects approximately 5% of Argentinean cattle. Among the molecular methods for genotyping, the most convenient are spoligotyping and variable number of tandem repeats (VNTR). A total of 378 samples from bovines with visible lesions consistent with TB were collected at slaughterhouses in three provinces, yielding 265 M. bovis spoligotyped isolates, which were distributed into 35 spoligotypes. In addition, 197 isolates were also typed by the VNTR method and 54 combined VNTR types were detected. There were 24 clusters and 27 orphan types. When both typing methods were combined, 98 spoligotypes and VNTR types were observed with 27 clusters and 71 orphan types. By performing a meta-analysis with previous spoligotyping results, we identified regional and temporal trends in the population structure of M. bovis. For SB0140, the most predominant spoligotype in Argentina, the prevalence percentage remained high during different periods, varying from 25.5-57.8% (1994-2011). By contrast, the second and third most prevalent spoligotypes exhibited important fluctuations. This study shows that there has been an expansion in ancestral lineages as demonstrated by spoligotyping. However, exact tandem repeat typing suggests dynamic changes in the clonal population of this microorganism.","palabras_clave":"BOVINE TB|MYCOBACTERIUM BOVIS|SPOLIGOTYPE|VNTR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3269,"idioma_id":5,"titulo":"Efecto de la adición de dimetilformamida al diluyente tris base sobre la supervivencia de espermatozoides felinos congelados-descongelados","resumen":"El objetivo de este trabajo fue evaluar el efecto de la adición de Dimetilformamida en reemplazo de parte de glicerol a un diluyente Tris base sobre la supervivencia espermática al descongelado en felinos. Se utilizaron 20 gatos, 16 se sometieron a orquiectomía bilateral para realizar la recuperación espermática de los epidídimos, y 4 fueron utilizados para la obtención de semen mediante electroeyaculación. Con los espermatozoides epididimales recuperados y el semen obtenido se realizó criopreservación utilizado un diluyente tris base con el agregado de 0.5% o 0% de dimetilformamida. El agregado de Dimetilformamida al Tris base no ejerció efectos protectores sobre los espermatozoides congelados-descongelados en comparación con la células criopreservadas con el diluyente Tris base. El agregado de un mayor porcentaje de amida podría mostrar efectos benéficos sobre los espermatozoides felinos al descongelado.","palabras_clave":"ESPERMATOZOIDES|GATO|SEMEN CONGELADO|CRIOPRESERVACIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3270,"idioma_id":5,"titulo":"Ajuste de modelos logísticos a la tasa de incremento de severidad de manchas foliares ocasionadas por Alternaria tenuissima en arándano","resumen":"La severidad de manchas foliares, ocasionadas por Alternaria tenuissima en arándano, fue observada en el cultivar O?Neal en San Pedro (59º 38? S; 33º 44? O), Concordia (31º 19? S; 58º 5? O) y Gualeguaychú (33º 01? S; 58º 30? O) durante tres ciclos epidémicos. Sobre las curvas epidémicas observadas, que ajustaron a modelos logísticos o Gompertz (R2 > 0,65, error bajo) se calcularon las tasas de incremento diario de severidad (TId%; N = 34), cuya variación se relacionó con variables meteorológicas y grado de senescencia foliar (Snc: 1 a 4), calculadas en lapsos de 10 a 28 días previos a cada valor observado de TId%. Se ajustaron modelos de regresión logística para estimar las probabilidades de ocurrencia de TId% severas (> 0,033 %) y moderadas a nulas (&#8804; 0,033 %). La variable DPrT (días con precipitación y temperaturas entre 19 y 36 °C) calculada en los 10 días previos a cada valor de TId% resultó la más fuertemente correlacionada (coeficiente de Kendall = 0,70). La mayor precisión de predicción (94,1 %) fue alcanzada por modelos bivariados, como los que integraron a DPrT y PrAc (acumulación de las precipitaciones diarias) y a DPrT y Snc. Los resultados confirman el lento progreso epidémico primaveral y las altas tasas de incremento estivales, concordantes con la mayor frecuencia de días con precipitación (fuente de mojado para la infección), con registros térmicos entre 19 y 36 °C. Hojas con senescencia creciente favorecen el incremento de tasas de infección.","palabras_clave":"MODELOS PREDICTIVOS|MANEJO DE ENFERMEDADES|ARÁNDANO ALTO|VACCINIUM CORYMBOSUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3271,"idioma_id":4,"titulo":"AN APPROACH TO URBAN TREE DAYLIGHT PERMEABILITY SIMULATION USING MODELS BASED ON LOUVERS","resumen":"In oasis cities urban forestation shades the lower level facades of buildings. It is thus crucial to analyze the distributional patterns of sun radiation produced by trees on facades. Nevertheless, the complexity of the canopies requires simplified representations for its study through simulation techniques. On the assumption that lighting behavior of trees, as sun control elements, more closely resembles a louver system rather than other frequently used solar control systems (e.g. perforated obstruction), the present study seeks to verify which of these formal simplifications adjusts better to the real case. The methodology used in this study relies on ray-trace simulation of solar control system models generated with hemispherical images. Comparisons are made between measured data of vertical illuminance (lux) in situ and those obtained through simulation for each of the models. Louvers model showed a high degree of adjustment (RMSE 9%). This study may be useful to streamline the analysis of urban trees impact in daylight availability on building facades through simulation.","palabras_clave":"DAYLIGHT|URBAN TREES|RAYTRACE|SOLAR CONTROL SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3272,"idioma_id":4,"titulo":"Phenotypic plasticity of the planthopper Delphacodes kuscheli (Hemiptera: Delphacidae) revealed by its selectivity, consumption rate and demographic traits on different food quality sites of wheat plants","resumen":"Delphacodes kuscheli, a phloem sap-sucking planthopper and the main vector of the Mal de Río Cuarto virus (MRCV) of maize in Argentina, was used to analyze phenotypic plasticity in behavior and demographic traits in response to different food quality, without masking the effects of density dependence and within-plant heterogeneity. We evaluated selectivity of nymphs and adults for different sites of wheat plants and, on sites suspected to have different food quality because of the presence\/absence of meristems and therefore different nitrogen content,we evaluated pre-imaginal survival, nymphal developmental time, proportion of macropterous morphs, adult longevity and feeding rate. Delphacodes kuscheli showed a positive selection for plant zones suspected to havehigher food quality and on them insects developed faster, exhibited higher nymphal survival and adult longevityand produced a lower proportion of macropterous morphs. Also on sites suspected to have lower food quality thenumber of honeydew droplets excreted per day increased and the mean diameter diminished, suggesting that the planthopper could probe more frequently to compensate for different food quality.","palabras_clave":"FOOSD QUALITY|PLANTHOPPER|PHENOTYPIC PLASTICITY|NITROGEN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3273,"idioma_id":4,"titulo":"Tripanocide Treatment of Women Infected with Trypanosoma cruzi, and its Effect on Preventing Congenital Chagas","resumen":"                        Abstract                        With the control of the vectorial and  transfusional routes of infection with Trypanosoma cruzi, congenital  transmission has become an important source of new cases.                        This study evaluated the efficacy of  trypanocidal therapy to prevent congenital Chagas disease and compared the  clinical and serological evolution between treated and untreated infected  mothers.                        We conducted a multicenter, observational study  on a cohort of mothers infected with Trypanosoma  cruzi, with and without trypanocidal treatment before pregnancy.Their  children were studied to detect congenital infection.                        Among 354 'chronically infected  mother-biological child' pairs, 132 were treated women and 222 were  untreated women. Among the children born to untreated women, we detected 34 infected  with Trypanosoma cruzi (15.3%), whose only antecedent was maternal  infection. Among the 132 children of previously treated women, no infection  with T. cruzi was found (0.0%) (p                         Among 117 mothers with clinical and serological  follow up, 71 had been treated and 46 were untreated.The women were grouped  into three groups. Group A: 25 treated before 15 years of age; Group B: 46  treated at 15 or more years of age; Group C: untreated, average age of 29.2 ±  6.2 years at study entry. Follow-up for Groups A, B and C was 16.3 ± 5.8, 17.5  ± 9.2 and 18.6 ± 8.6 years respectively. Negative seroconversion: Group A,  64.0% (16\/25); Group B, 32.6% (15\/46); Group C, no seronegativity was  observed.Clinical electrocardiographic alterations compatible with chagasic  cardiomyopathy: Group A 0.0% (0\/25); B 2.2% (1\/46) and C 15.2% (7\/46).                        The  trypanocidal treatment of women with chronic Chagas infection was effective in  preventing the congenital transmission of Trypanosoma cruzi to their  children; it had also a protective effect on the women?s clinical evolution and  deparasitation could be demonstrated in many treated women after over 10 years  of follow up.                                                  Author Summary (150-200 words)                                                 Congenital infection with Trypanosoma cruzi  is the most common mode of transmission in countries where the vectorial and  transfusional routes have been controlled.                        We evaluated the efficacy of trypanocidal  therapy in preventing congenital Chagas disease and compared the clinical and  serological changes between treated and untreated mothers. From medical records  of infected women with and without trypanocidal treatment, we studied their  children to detect congenital infection. Among 222 children of untreated  mothers, we detected 34 cases of congenital transmission. The 132 children of  previously treated women were born without infection.                        In 117 mothers followed for more than eight  years, we observed negative serology for Chagas in 43.7% of the treated women  and none in untreated mothers. Regarding their clinical course, there was also  a positive difference for treated women (2.2%), compared with untreated ones  (15.4%). These results indicate the benefit of providing etiologic treatment to  young people with chronic infection. This recommendation would have a major  health impact both in primary prevention, preventing further cases of  congenital Chagas disease, and in secondary prevention, reducing the risks of  morbidity and mortality that can cause infection.                           ","palabras_clave":"CHAGAS DISEASE|CHILDREN|DRUG THERAPY|TRYPANOSOMA CRUZI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3274,"idioma_id":4,"titulo":"CYTOGENETIC CHARACTERIZATION OF THE GERMPLASM OF WILD CHILI PEPPERS: CAPSICUM BACCATUM VAR. PRAETERMISSUM","resumen":"In: Marhold K (ed.), IAPT\/IOPB chromosome data 18. TAXON 63(6): 1387 (edición impresa resumida, ISSN 0040-0262); E1-E3 (online full version, ISSN 1996-8175).Capsicum rhomboideum is a diploid, based on x = 13 wild chili pepper that naturally inhabits in México, Guatemala,  Honduras, Colombia, Venezuela, Ecuador and Perú. This taxon grows as a shrub or a small tree with rotate and particularly yellow flowers, spherical red sweet fruits and brownish seeds. An exhaustive cyto-molecular description of C.rhomboideum was performed by means of diverse approaches. In combination, these cytological markers permitted to distinguish unequivocally each chromosome pair of this species. Polymorphisms for the cytological markers were not detected. Our results, coupled to previous studies on the karyotype of C. rhomboideum sustain an ancestral state for this species in the phylogeny of Capsicum. In addition, molecular studies on the 5S rRNA NTS sequence and the particular red nonpungent sweet fruits of C.rhomboideum clearly corroborate its ancestral condition.","palabras_clave":"FLUORESCENCE BANDING|FISH|KARYOTYPE|ANCESTRAL CONDITION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3275,"idioma_id":4,"titulo":"&#946;1-Selective Adrenoceptor Antagonists Increase Plasma Levels of Anti-p2&#946; Antibodies and Decrease Cardiac Involvement in Chronic Progressive Chagas Heart Disease.","resumen":"Background: Studies indicate that antibodies cross-reacting with  cardiac b1 adrenergic receptors are likely to play a role in the development  of chronic Chagas heart disease (CCHD). In parallel, clinical  trials have shown that b1 antagonist drugs exert beneficial effects in  the prognosis of patients with CCHD. In a group of patients with CCHD  undergoing therapy with b1-blockers, we have now evaluated the  levels of anti-p2b antibodies and the severity of CCHD.  Methods: We performed a cross-sectional study in Trypanosoma cruzi  seropositive patients categorized according to a standard CCHD classification. All individuals were subjected to a complete clinical  examination.  Results: There was no association between CCHD stages, electrocardiographic  conduction disturbances, and echocardiogram pathological  signs with the levels of autoantibodies. However, when patients were  analyzed according to selective cardio-b1-blocker therapy, those  receiving treatment had higher levels of anti-p2b. Patients from CCHD  stage III treated with combined therapy of cardio-b1-selective blockers,  enalapril, and statins, presented decreased cardiac involvement and  lower score of risk of mortality than individuals from the same group  who were not treated.  Conclusions: Our results suggest that selective cardio-b1-blockers  might modify the autoantibody anti-p2b levels, and that combined  therapy in patients with stage III CCHD might be associated with lower  cardiac involvement and risk score of mortality in patients with heart  failure. Longitudinal studies will help to ascertain the proper role of b1-blockers in the immunopathological processes underlying chronic  Chagas disease.","palabras_clave":"Chagas Disease|P2b|antibodies|adrenoceptor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3276,"idioma_id":5,"titulo":"Una mirada sobre el acceso abierto en Iberoamérica. Entrevista a Remedios Melero","resumen":"\t\t\t\t\t\t\t\t\t\t\t\t&nbsp;Esta contribucio&#769;n, realizada en mayo de 2011 yactualizada en 2014, pretende acercar a los lectores de la revista una charlaamena e interesante entre Remedios Melero, una de las principales referentes enmateria de acceso abierto en Espan&#771;a e Iberoame&#769;rica, y miembros del proyectode investigacio&#769;n El acceso abierto al conocimiento cienti&#769;fico en Argentina. Estadode la cuestio&#769;n y principales tendencias (H540), radicado en la Facultad deHumanidades y Ciencias de la Educacio&#769;n de la Universidad Nacional de La Plata.\t\t\t\t\t\t\t\t\t","palabras_clave":"Acceso Abierto"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3277,"idioma_id":4,"titulo":"Prevalence of dyslipidemia and metabolic syndrome risk factor  in overweight and obese children","resumen":"Objective: To study the prevalence of dyslipidemiaand metabolic syndrome risk factors in overweight\/obese children and adolescents.Methodology: The study included 139 healthy whiteArgentinean children\/adolescents (aged 8-14 years) whowere overweight (n=30) or obese (n=109), based on BMIz score according to WHO, 2007. Children were referredto the Nutrition Clinic, San Martin University Hospital,Buenos Aires, Argentina for evaluation and treatment.Dyslipidemia was considered when one or more serumlipids (mg\/dL) were out of range: total cholesterol &#8805;200,high-density lipoprotein (HDL-C) &#8804;40, triglycerides (TG)&#8805;110, low-density lipoprotein (LDL-C) &#8805;130 or non-HDL-C>145 and fasting blood glucose (FBG) > 110. Additionalmetabolic syndrome risk factors included: increased waistcircumference (WC, &#8805;90th percentile) and high bloodpressure (>90th percentile). A history of low birth weight(<2.5 kg) and a family history of: dyslipidemia (FHDL),premature acute myocardial infarction (FHPAMI) and\/ortype 2 diabetes mellitus (FHT2DM) were also assessed.Results: The prevalence of dyslipidemia among overweightand obese children was 50.4% and its pattern was:hypertriglyceridemia 31.7%, low HDL-C 29.5%, high nonHDL-C15.8%, hypercholesterolemia 11.5%, and elevatedLDL-C 10.1%. The dyslipidemia was more often detected among those with increased WC (55.4%), FHDL (51.1%),and FHT2DM (48%); prevalence was lower in those withFHPAMI (18.7%) and low birth weight (4.3%). Most childrenpresented a variety of metabolic syndrome risk factors;only 25% did not have any such alterations identified.BMI z score showed a positive association with TG andnegative with HDL-C. Overweight and obesity increasedthe odds ratios of metabolic syndrome risk factors,hypertriglyceridemia and low HDL-C.Conclusions: Overweight\/obese children were proneto have dyslipidemia and metabolic syndrome. Excessbody weight is an important harbinger of health thatrequires the assessment of multiple parameters to discernfurther health concerns that may be amenable to specifictreatment.","palabras_clave":"Obesity|Overweight|Metabolic syndrome| Hyperlipidemia|Dyslipidemia| Hypertriglyceridemia|Hypercholesterolemia|Hypertension| Cardiovascular disease|Type 2 Diabetes Mellitus|Children| Adolescents"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3278,"idioma_id":4,"titulo":"Developmental expression and role of kinesin Eg5 during  Xenopus laevis embryogenesis","resumen":"                                      Background: The  neural crest is a transient multipotent migratory cell population unique to  vertebrates. These cells undergo an epithelial-to-mesenchymal transition and  migrate extensively through the embryo. They differentiate into numerous  diverse derivatives including the peripheral nervous system, melanocytes and  craniofacial cartilages. The development of the neural crest is mediated by  complex interactions of multiple signals and transcription factors. The kinesin  Eg5 is a plus end directed  microtubule-based motor protein that is essential for bipolar spindle formation  during mitosis and meiosis, axon growth and mammal embryonic development.                                      Results: We  analyzed in detail the expression pattern of the kinesin Eg5 and established that it is expressed at the prospective neural  fold, in the premigratory and migratory neural crest. Functional analysis  revealed that in Xenopus early embryogenesis  Eg5 function is required                                      during neural crest induction, specification  and maintenance. Eg5 is also required  during neural crest migration and for derivatives formation. Moreover, we  demonstrated a hierarchical relationship with the Indian Hedgehog signaling  pathway.                                       Conclusions: Our results show that Eg5 is essential for the specification  and maintenance of neural crest progenitors during Xenopus early  embryogenesis rather than for cell proliferation and survival.  ","palabras_clave":"CELL SPECIFICATION|MORPHOLINO|MONASTROL|NEURAL CREST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3331,"idioma_id":4,"titulo":"A regional survey of crop response to sulfur fertilization in the Pampas of Argentina. Agrochimica (Aceptado en prensa), 2015.","resumen":"SUMMARYNitrogen and phosphorus fertilizer have beenused since many years in the Pampas but sulfurfertilization is incipient and the response of crops poorly understood. Weperformed a surface balance which indicated that main input has beenatmospheric deposition with a small contribution of fertilizers. Sulfur outputwas mainly grain harvest. Pampean agroecosystems lost 1.68 Mt of sulfur during140 years of cultivation. The input\/output ratio varied from 2.3 to 0.7 in this period. Themetaanalysis of 465 sparse field experiment performed in the region, in whichthe response of the main crops to sulfur was assessed, showed generalized yieldincrements. The response could not be predicted using soil sulfate-S content,organic matter level or S-rate fertilizer. Average agronomic efficiencies attainedwere calculated. Using these efficiencies it was estimated that the widespreadadoption of the sulfur fertilization practice would allow increasing pampeangrain production by 11% which is profitable for farmers. The probability ofpositive yield increments due to fertilization ranged from 55 to 75% dependingon the crop. ","palabras_clave":"Sulfur balance|Input\/output"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3334,"idioma_id":5,"titulo":"Acerca de indicadores de vulnerabilidad para la salud adolescente: soledad y aislamiento en población del Norte Argentino","resumen":"Este estudio tuvo como objetivo evaluar  indicadores de soledad y aislamiento autopercibida por 412 adolescentes  escolarizados residentes en Tucumán y Santiago del Estero, provincias del norte  de Argentina. Se trató de un estudio comparativo, transversal con muestreo  accidental. Se les aplicó el Cuestionario de Aislamiento y Soledad, la Batería  de Socialización (BAS-3) y una encuesta sociodemográfica. El 28% manifestaba  comportamientos riesgosos en soledad y el 25% en aislamiento. Dentro de este  grupo se observó que un 7% de éstos referían comportamientos con mayor  propensión psicopatológica. El grupo con riesgo en soledad presentaba déficits  sociales caracterizados por una menor consideración por los demás, un menor liderazgo  y un mayor retraimiento respecto a sus pares sin riesgo. En tanto, el grupo con  mayor riesgo mostraba un menor autocontrol ante situaciones sociales. Los datos  descriptos permiten identificar indicadores de riesgo que originan o influyen  en comportamientos psicopatológicos de población adolescente escolarizada.&nbsp;&nbsp;&nbsp; ","palabras_clave":"SALUD|ADOLESCENTE|SOLEDAD |CONTEXTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3346,"idioma_id":5,"titulo":"BARRERAS Y FACTORES CLAVES PARAR PROMOVER LA EFICIENCIA ENERGETICA EN LA INDUSTRIA","resumen":"RESUMEN El sector industrial, responsable de más de la tercera parte de la demanda global de energía primaria y de las emisiones de CO2, tiene un alto potencial técnico para reducir la intensidad energética, y de esa forma contribuir a la mitigación del cambio climático, la seguridad energética y la sostenibilidad en sentido general. El aprovechamiento de este potencial requiere del establecimiento de políticas públicas y el desarrollo de programas específicos encaminados a la elevación de la eficiencia energética en el sector industrial. Sobre la base de experiencias internacionales y de opiniones de directivos y técnicos de empresas industriales, en el trabajo se resumen las principales barreras a superar para el desarrollo exitoso de los programas de eficiencia energética en la industria. Finalmente, a partir del análisis de la implementación de programas nacionales de eficiencia energética en la industria en diferentes países, se identifica un conjunto de factores claves para el éxito de estos. ","palabras_clave":"Eficiencia energética|Gestión energética|Sector industrial."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3347,"idioma_id":4,"titulo":"ETHNOARCHAEOLOGY OF HUNTER-FISHER-GATHERERS SOCIETIES IN THE BEAGLE CHANNEL (TIERRA DEL FUEGO): ETHNOGRAPHICAL SOURCES AND SOCIAL SIMULATION.","resumen":"Ethnoarchaeology of hunter-fisher-gatherers societies in the Beagle Channel(Tierra del Fuego): ethnographical sources and social simulation. Theethnoarchaeological research from the Beagle Channel (Tierra del Fuego)offers a rich ethnographical and historical record, produced by the lateinclusion of Tierra del Fuego in the industrial world (the Beagle Channel wasdiscovered by R. Fitz-Roy in 1830). This is an interesting frame for using newtechniques (social simulation by Agent based modelling (ABM)) to generatenew hypothesis in archaeology. In this case, the hypothesis is focused on therole of social cooperation in Yámana hunter-fisher-gatherer society.","palabras_clave":"COOPERATION|SOCIAL SIMULATION|YAMANA|HUNTER-GATHERERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3348,"idioma_id":4,"titulo":"Stable tridimensional bubble clusters in multi-bubble sonoluminescence (MBSL)","resumen":"In the present work, stable clusters made of multiple sonoluminescent bubbles are experimentally and theoretically studied. Argon bubbles were acoustically generated and trapped using bi-frequency driving within a cylindrical chamber filled with a sulfuric acid aqueous solution (SA85\textit{w\/w}). The intensity of the acoustic pressure field was strong enough to sustain, during several minutes, a large number of positionally and spatially fixed (without pseudo-orbits) sonoluminescent bubbles over an ellipsoidally-shaped tridimensional array. The dimensions of the ellipsoids were studied as a function of the amplitude of the applied low-frequency acoustic pressure ($P_{Ac}^{LF}$) and the static pressure in the fluid ($P_0$). In order to explain the size and shape of the bubble clusters, we performed a series of numerical simulations of the hydrodynamic forces acting over the bubbles. In both cases the observed experimental behavior was in excellent agreement with the numerical results. The simulations revealed that the positionally stable region, mainly determined by the null primary Bjerknes force ($\u000Bec{F}_{Bj}$), is defined as the outer perimeter of an axisymmetric ellipsoidal cluster centered in the acoustic field antinode. The role of the high-frequency component of the pressure field and the influence of the secondary Bjerknes force are discussed. We also investigate the effect of a change in the concentration of dissolved gas on the positional and spatial instabilities through the cluster dimensions. The experimental and numerical results presented in this paper are potentially useful for further understanding and modeling numerous current research topics regarding multi-bubble phenomena, e.g. forces acting on the bubbles in multi-frequency acoustic fields, transient acoustic cavitation, bubble interactions, structure formation processes, atomic and molecular emissions of equal bubbles and nonlinear or unsteady acoustic pressure fields in bubbly media.","palabras_clave":"Multi-bubble sonoluminescence (MBSL)|Static pressure|Bi-frequency driving|Positional instability|Bjerknes force|Bubble clusters"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3349,"idioma_id":5,"titulo":"Estadísticas, costos y margen bruto del cultivo de caña de azúcar, campaña 2012\/13 vs 2013\/14 y gasto de plantación para la zafra 2015 en Tucumán","resumen":"Analiza la superficie, rendimiento y producción del cultivo de caña de azúcar en Tucumán en la campaña 2013\/14 vs 2012\/13. También analiza los gastos de producción, MB y puntos de indiferencia para ambas campañas, y los gastos de plantación para la plantación 2015.","palabras_clave":"CAÑA|SUPERFICIE|GASTOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3350,"idioma_id":4,"titulo":"Differential contribution of Tacaribe arenavirus Nucleoprotein N-terminal and C-terminal residues to nucleocapsid functional activity","resumen":"The arenavirus nucleoprotein (NP) is the main protein component of viral nucleocapsids and is strictly required for viral genomereplication mediated by the L polymerase. Homo-oligomerization of NP is presumed to play an important role in nucleocapsidassembly, albeit the underlying mechanism and the relevance of NP-NP interaction in nucleocapsid activity are stillpoorly understood. Here, we evaluate the contribution of the New World Tacaribe virus (TCRV) NP self-interaction to nucleocapsidfunctional activity. We show that alanine substitution of N-terminal residues predicted to be available for NP-NP interactionstrongly affected NP self-association, as determined by coimmunoprecipitation assays, produced a drastic inhibition oftranscription and replication of a TCRV minigenome RNA, and impaired NP binding to RNA. Mutagenesis and functional analysisalso revealed that, while dispensable for NP self-interaction, key amino acids at the C-terminal domain were essential forRNA synthesis. Furthermore, mutations at these C-terminal residues rendered NP unable to bind RNA both in vivo and in vitrobut had no effect on the interaction with the L polymerase. In addition, while all oligomerization-defective variants tested exhibitedunaltered capacities to sustain NP-L interaction, NP deletion mutants were fully incompetent to bind L, suggesting that,whereas NP self-association is dispensable, the integrity of both the N-terminal and C-terminal domains is required for bindingthe L polymerase. Overall, our results suggest that NP self-interaction mediated by the N-terminal domain may play a criticalrole in TCRV nucleocapsid assembly and activity and that the C-terminal domain of NP is implicated in RNA binding.","palabras_clave":"tcrv|nucleoprotein"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3351,"idioma_id":4,"titulo":"Far transfer to language and math of a short software-based gaming intervention","resumen":"Executive functions (EF) in children can be trained, but it remains unknown whether training-related benefits elicit far transfer to real-life situations. Here, we investigate whether a set of computerized games might yield near and far transfer on an experimental and an active control group of low-SES otherwise typically developing 6-y-olds in a 3-mo pretest-training-posttest design that was ecologically deployed (at school). The intervention elicits transfer to some (but not all) facets of executive function. These changes cascade to real-world measures of school performance. The intervention equalizes academic outcomes across children who regularly attend school and those who do not because of social and familiar circumstances.","palabras_clave":"cognitive training intervention|attention|working memory|school attendance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3352,"idioma_id":4,"titulo":"Gastrointestinal parasites of bottlenose dolphins Tursiops truncatus at the southern extreme of the southwestern Atlantic, with notes on diet composition","resumen":"We surveyed the gastrointestinal tracts of 6 bottlenose dolphins Tursiops truncatus from Patagonia to check for helminth parasites and characterize dolphin diet. All dolphins harbored parasites (6477 helminths). We recorded 7 species, including nematodes Anisakis simplex s.l., Pseudoterranova decipiens, acanthocephalans Corynosoma cetaceum, C. australe, and digeneans Braunina cordiformis, Pholeter gastrophilus and Synthesium tursionis. Among the gastric helminths, the most prevalent species were C. cetaceum and A. simplex while C. australe and S. tursionis inhabited the intestine at low prevalence. This is the first report of C. australe and P. decipiens in bottlenose dolphins. Regarding diet, 5 stomachs contained food remains (consisting of 103 prey items). The most important prey species were Geotria australis and Stromateus brasiliensis, but their role in parasite transmission is unclear. At the community level, the gastro - intestinal parasite community of T. truncatus was depauperate and strongly overlapped the community described for pelagic dolphins inhabiting Patagonia, suggesting a strong local Influence in shaping helminth communities. Nevertheless, these Observations are at odds with the notion that oceanic cetaceans have comparatively poorer helminth fauna than neritic species such as bottlenose dolphins, due to the lower likelihood of parasite exchange.","palabras_clave":"Tursiops truncatus|Corynosoma|Anisakis|Pseudoterranova|Braunina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3353,"idioma_id":4,"titulo":"Characterization of a bacteriocin produced by Lactococcus lactis subsp. lactis CRL 1584 isolated from a Lithobates catesbeianus hatchery","resumen":"Lactococcus lactis CRL 1584 isolated from a Lithobates catesbeianus hatchery inhibits the growth of Citrobacter freundii (a bullfrog pathogen) and Listeria monocytogenes by a synergistic effect between lactic acid,hydrogen peroxide and a bacteriocin-like molecule. The  chemical characterization of the bacteriocin in cell-free supernatants indicates that it has a proteinaceous nature. Hexadecane and ethyl acetate did not modify the bacteriocin activity, while 10 and 20 % (v\/v) chloroform decreased the activity by 29 and 43 %, respectively. The  antimicrobial peptide was heat stable since 85 % of residual activity was detected when neutralized supernatants were heated at 80 C for 30 min. Moreover, no bacteriocin inactivation was observed when supernatants were  kept at -20 C for 3 months. The synthesis of the bacteriocin was associated with bacterial growth, highest production (2,100 AU\/ml) being detected at the end of the exponential growth phase. At pH ranges of 5?6.5 and 5.0?5.5 the inhibitory molecule was stable when stored for 2 days at 4 and 25 C, respectively. Moreover, it had a bactericidal effect on L. monocytogenes and the ultrastructural studies of pathogenic cells revealed clumping of the cytoplasmic material, increased periplasmic Space and cell wall modifications. The deduced amino acid sequence of the bacteriocin was identical to nisin Z and the genetic determinants for its production are harbored in the chromosome. These results, described for the first time in L. lactis from a bullfrog hatchery, will increase knowledge of the bacteriocin under study with a view to its potential  inclusion in probiotics for raniculture or biopreservatives.","palabras_clave":"LACTOCOCCUS LACTIS|RANICULTURE|BACTERIOCIN|INFECTIOUS DISEASES|PROBIOTIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3355,"idioma_id":4,"titulo":"Epidemiology and antifungal susceptibilities of yeasts causing vulvovaginitis in a teaching hospital.","resumen":"Vulvovaginal candidiasis is one of themost  common mycosis. However, the information about  antifungal susceptibilities of the yeasts causing this  infection is scant. We studied 121 yeasts isolated from  118 patients with vulvovaginal candidiasis. The isolates  were identified by phenotypic and molecular methods,  including four phenotypic methods described to differentiate  Candida albicans from C. dubliniensis. Antifungal  susceptibility testingwas performed according to  CLSI documents M27A3 and M27S4 using the drugs  available as treatment option in the hospital. Diabetes,  any antibacterial and amoxicillin treatment were  statistically linked with vulvovaginal candidiasis, while  oral contraceptives were not considered a risk factor.  Previous azole-based over-the-counter antifungal treatment  was statistically associated with non-C.albicans  yeasts infections. The most common isolated yeast  species was C. albicans (85.2 %) followed by C.  glabrata (5 %), Saccharomyces cerevisiae (3.3 %),  and C. dubliniensis (2.5 %). Fluconazole- and itraconazole-  reduced susceptibility was observed in ten and in  only one C. albicans strains, respectively. All the C.  glabrata isolates showed low fluconazole MICs. Clotrimazole  showed excellent potency against all but  seven isolates (three C. glabrata, two S. cerevisiae, one  C. albicans and one Picchia anomala). Any of the  strains showed nystatin reduced susceptibility. On the  other hand, terbinafine was the less potent drug.  Antifungal resistance is still a rare phenomenon  supporting the use of azole antifungals as empirical  treatment of vulvovaginal candidiasis.","palabras_clave":"Yeast \u0002   \u0002 |Vulvovaginitis|\u0002 Identification|Susceptibility"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3356,"idioma_id":5,"titulo":"DESCRIPCIÓN ANATÓMICA DEL ESQUELETO APENDICULAR DEL CARPINCHO (HIDROCHOERUS HIDROCHAERIS)","resumen":"ResumenBode, F.F.; Cao, J.A.; Resoagli, J.M.; Fernández, J.A.; Llano Laiseca, E.: Descripciónanatómica del esqueleto apendicular del carpincho (Hydrochoerus hydrochaeris). Rev.vet. 25: 1, 21-26, 2014. El ?carpincho? es una de las especies autóctonas del nordeste argentinoy asume importancia económica, evidenciada por los numerosos programas nacionalesy regionales para su explotación. La información anatómica sobre el esqueleto apendicularde esta especie es escasa. El objetivo de este trabajo fue describir los huesos de las extremidades(esqueleto apendicular) del Hydrochoerus hydrochaeris, ordenados topográficamentede proximal a distal, utilizando la nomenclatura anatómica veterinaria, así comocompararlos con los de otras especies. Los huesos se obtuvieron por maceración, siendoluego tratados con hipoclorito de sodio al 20%. Las descripciones anatómicas se avalaroncon registros fotográficos. El análisis osteológico apendicular comprendió cuatro segmentos,tanto para miembros anteriores (escápula, brazo, antebrazo, mano) como posteriores (coxal,muslo, pierna, pie), los cuales revelaron particularidades osteológicas propias de la especie.Se espera que los estudios anatómicos de H. hydrochaeris contribuyan a mejorar su manejosanitario y productivo.","palabras_clave":"Hydrochoerus hydrochaeris,| anatomía,|esqueleto A pendicular"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3357,"idioma_id":5,"titulo":"Trastornos cognitivos en pacientes con HIV-1: la dimensión pragmática de la comunicación verbal","resumen":"Introducción: La alteración de funciones neurocognitivas es una complicación frecuente en pacientes con virus de inmunodeficiencia humana (VIH). A pesar de esto, las dificultades pragmáticas y, en especial, en habilidades de comunicación verbal han sido poco abordadas en esta población de pacientes. Objetivos: Nos propusimos estudiar las habilidades de comunicación verbal en una muestra de paciente VIH-1, mediante la aplicación del Protocolo MEC. Método: Se evaluaron 20 pacientes que asistían al servicio de Infectología del Hospital Thompson (San Martín, provincia de Buenos Aires) y que cumplían con los siguientes criterios de inclusión: 18 años o más, VIH-1 positivo, hablantes nativos de español, sin alteraciones en la adquisición del lenguaje, la lectura o la escritura, sin antecedentes de enfermedad neurológica o psiquiátrica, pacientes que reciben TARV -Tratamiento antirretroviral- o que no reciben TARV (que no incluya efavirenz\/ con carga viral detectable [>50 cop\/mL]). Fueron evaluados con el Protocolo MEC, que valora las habilidades de comunicación verbal. Resultados: Los resultados demuestran que algunas de las habilidades evaluadas por las diferentes pruebas de Protocolo MEC son más vulnerables al déficit en pacientes VIH-1. Las tareas que mostraron  déficits más sistemáticos y frecuentes fueron las del nivel del discurso y las que evalúan el procesamiento léxico semántico. Conclusión: La detección de déficits de comunicación en pacientes VIH-1 puede contribuir con la identificación de trastornos cognitivos y la admisión de los pacientes al sistema de salud.","palabras_clave":"VIH 1|TRASTORNOS COGNITIVOS|COMUNICACIÓN VERBAL|PRAGMÁTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3358,"idioma_id":4,"titulo":"A high-resolution palaeoclimate record for the last 4800 years from Lake La Brava, SE pampas plains, Argentina","resumen":"Climatic changes are reflected in variations of different parameters. Sequences of lakesediments are good sources of this information because they provide continuous anddetailed records of palaeoclimatic changes. In order to determine the changes inclimate in SE Pampas plain,in this paper we present a series of rock magnetic studiesperformed on a bottom core collected from Lake La Brava (Argentina).In order to establish lake level variations, we also measure total sulphur, organic andinorganic carbon (TS, TOC and TIC) content,alkaline elements, light and heavy metalsand changes in vegetation communities. Five radiocarbon age determinations weremade from samples of organic-rich clay and calibrated ages were calculated. Theaveraged sediment accumulation rate is 1.3 mm\/yr and the sequence represents atemporal extent of about 4800 calibrated years before the present (cal. BP).The main aim was to reconstruct the hydrological balance of the lake, the changes inerosional strength and sediment supply within the catchment area since the MiddleHolocene, and to explore the extent to which these may be linked to changes in climateand\/or human activities.The results of this work and previous studies suggest periodicchanges from cooler to warmer and humid conditions. Relationships betweensubmerged and emergent plants are consistent with the behaviour of magneticsusceptibility.TOC changes suggest wet environment during magnetic enhancement.Floods and lower lake level events were identified in detail. Changes in sedimentcontribution and depositional processes for the last 50 cal. BP are caused by humanimpact, particularly by the use of natural resources.","palabras_clave":"PALEOCLIMATIC CHANGES|ROCK MAGNETISM|SEDIMENT CORES|SOUTH AMERICA|LAKE LEVEL|DRY EVENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3359,"idioma_id":4,"titulo":"Database for accidents and incidents in the biodiesel industry (Indexed by Thomson Reuters)","resumen":"The present paper describes the development of an accident and incident database for the Biodiesel Industry for the period 2003-November 2013. The work performed is related to the collection of data from different documental sources and the subsequent setting of a database containing general information about adverse events, its sequence, mitigation, causes, and human, environmental and material consequences occurred in biodiesel facilities during the last ten years. This database came to fill a gap existing in this field. Availability of these data will allow applying risk analysis tools, having a management tool to check organization performance, generating lessons learned to avoid accident recurrence and identifying those accidents more likely to occur. Data statistical analysis shows that the frequency of accidents in biodiesel plants has an increasing tendency, being fires and explosions the main type of accidents that occurred. Inmediate causes and consequences of the accidents have also been analized. Finally, some conclusion are drawn concerning the need of maintaining an update accidental and incidental database and improving biodiesel plants safety based on information obtained.","palabras_clave":"ACCIDENTS|INCIDENTS|BIODIESEL|RISK"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3361,"idioma_id":4,"titulo":"PCR-based prediction of type I beta-exotoxin production in Bacillus thuringiensis strains.","resumen":"Some Bacillus thuringiensis strains secrete type I â-exotoxin, which is a non-specific insecticidal and thermostable adenine nucleoside oligosaccharide. Toxicity bioassays and HPLC are traditional methods for detecting â-exotoxin. With the aim of establish a first rapid approach for prediction of type I â-exotoxin production, two PCR-based methods were successfully evaluated in B. thuringiensis strains and native isolates. In order to validate a reliable technology, results obtained by this method were correlated with that obtained from Musca domestica bioassays.","palabras_clave":"Bacillus thuringiensis|beta exotoxin|thuE gene |PCR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3363,"idioma_id":5,"titulo":"Variabilidad y correlaciones de caracteres vinculados con el vigor de plántula en dos poblaciones naturales de Pappophorum vaginatum Buckley","resumen":"It was evaluated variability and phenotypic correlation in traits related to seedling vigor in two natural populations of P.vaginatum. They were weighted and sowed individually 100 caryopses of each population ('A'; 'B'). After 43 days it was determined: lengths aerial (LA), root (LR), total (LT) and longest adventitious root (Ladv), number of adventitious root (n°adv), of leaves (n°hoj), of senescent leaves (n°sen) and of tillers (n°mac) and dry weight aerial (PSA) and root (PSR). It was calculated total dry weight (PST), PSA\/PSR and LA\/LR. Variability was analyzed by means of descriptive statistic and t test. It was analyzed correlation among traits and multiple regression of traits on PST. Populations did not differ in PST (p higher than 0.05). 'A' had greater (p lower than 0.01) PSA\/PSR, LA\/LR and LA. 'B' had higher (p mayor 0.05) LR, Ladv and PSR. Both populations showed significant and positive correlation of PST with LA, LT, Ladv, n°adv, n°hoj y n°mac. The regression was significant (p lower than 0.01). The variability found within and between populations implies expectations of response to selection. PST varied only within populations suggesting the convenience of intrapopulation selection. The association found between the traits LA and n°mac and the seedling vigor, should be considered for the genetic improvement of the implantation.","palabras_clave":"Pappophorum vaginatum|Vigor de plántula|Variabilidad|Correlaciones fenotípicas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3364,"idioma_id":4,"titulo":"Mathematical modelling of a dip coating process using a generalised newtonian fluid II. Model validation and sensitivity analysis","resumen":"Dip coating consists in the immersion of a substrate into a reservoir containing a film-forming fluid and then, the withdrawing from the bath to produce the film. The objective of this work was to develop a mathematical model of the fluid dynamic variables in a dip coating process, considering that the film-forming fluid behaves as a generalised Newtonian fluid. An analytical and simple mathematical model that relates the main fluid parameters using a generalised Herschel-Bulkley model was proposed. This model was obtained based upon rigorous mass and momentum balances applied to a monophasic and non-evaporative system, where the main forces are viscous and gravitational. The parameters that can be estimated are: velocity profile, average velocity, flow rate, local thickness, and average thickness of the coating film. Finally, the sufficient conditions for the model were obtained. The experimental validation and sensitivity analysis are presented in a complementary paper as Part II.","palabras_clave":"MATHEMATICAL MODELLING|DIP COATING PROCESS|GENERALISED NEWTONIAN FLUID|TRANSPORT PHENOMENA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3434,"idioma_id":4,"titulo":"MTs in Palaemonetes argentinus as potential biomarkers of zinc contamination in freshwaters","resumen":"Aquatic invertebrates take up and accumulate essential and non-essential trace metals even when both are likely to be poisonous. In order to study the potential of the metallothioneins (MTs) as biomarkers of metal contamination in native shrimp Palaemonetes argentinus, organisms have been  exposed at 0, 5, 50and 500 mg L1 of zinc for 96 h. Moreover, accumulation and subcellular distribution of this essential metal were evaluated. A significant Zn accumulation was observed in different body sections. Higher Zn levels occurred in cephalothorax compared to abdomen, especially at the highest exposure concentration (500 mg Zn L1). A clear differential subcellular metal distribution between cephalothorax and abdomen was also observed. In cephalothorax Zn was similarly distributed between the soluble and insoluble fractions; while in abdomen, when total Zn increased, insoluble metal augmented more markedly than the soluble one. Cytosolic Zn levels increased more in cephalothorax than in abdomen of shrimps exposed to 500 mg Zn L1 when compared to control. Finally, a significant induction of MTs was observed in cephalothorax at 500 mg Zn L1. A potential role for MTs as biomarkers in P. argentinus should be further studied to enhance the sensitivity of the response, although it is likely that MTs play a key role in metal detoxification since the increase of these proteins is linked to metal challenge.","palabras_clave":"Metal accumulation|Metallothioneins|Native species|Shrimp|Palaemonetes argentinus|Zn"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3436,"idioma_id":5,"titulo":"Nuevas lógicas y sentidos de la práctica de la Práctica Profesional","resumen":"Desde el espacio curricular de formación de grado, la Práctica Pre-profesional de Terapia Ocupacional de la Universidad Nacional del Litoral,  retomamos y profundizamos algunas cuestiones planteadas en torno al supuesto de la práctica como productora de contextos. Problematizamos sobre los modelos de pensamiento disciplinares que resultan insuficientes en la práctica profesional contextualizada. Interpelamos  y reflexionamos desde y sobre la práctica,  entre la mirada teórica tradicional centrada en la función- disfunción del individuo y el surgimiento del paradigma emergente en la profesión, enfocado en la promoción de salud y derechos en los grupos y poblaciones, redimensionando la noción de ocupación colectiva.Intentando comprender los modos de vida de las poblaciones y la producción del conocimiento en la posmodernidad  que nos atraviesa, tomamos los aportes de Souza Santos para proponer niveles de análisis y teorización sobre la práctica profesional como productora de contextos.La discusión nos aproxima a las siguientes reflexiones: a- reconocer como objeto de la disciplina al sujeto comprometido en sus ocupaciones, b- re significar las categorías de conocimiento y niveles de teorización de la práctica, c- estar implicados en la realidad de los contextos. Las mismas se plasmaron en la reasignación de los perfiles de centros de prácticas y construcción de nuevos escenarios, no convencionales, donde poner en juego  otras lógicas y sentidos desde la perspectiva de promoción de la salud.","palabras_clave":"TERAPIA OCUPACIONAL|PRACTICA PROFESIONAL|CONTEXTO|PARADIGMA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3437,"idioma_id":5,"titulo":"Análisis de Planes de Estudio Mediante Determinación Automática de Pertinencias Sintáctico-Temáticas en Carreras de Informática. Caso de Estudio: Carrera Licenciatura en Ciencias de la Computación","resumen":"El presente trabajo propone una metodología automática para determinar las pertinencias sintáctico-temáticas entre los contenidos mínimos de carreras de informática con las normas establecidas según las diferentes  titulaciones asignadas a las mismas.    El proceso automático agrupa los contenidos mínimos de las carreras estableciendo el grado de similitud sintáctica de estos, con  las áreas u objetivos temáticos de las resoluciones o marcos regulatorios correspondientes, favoreciendo así, un análisis inicial de planes de estudio que pueda llevar a la decisión de hacer correcciones sobre los mismos.    La aplicación se llevó adelante mediante la utilización los módulos de modelado y minería de texto (TextMining -TM-) de la herramienta de software libre RapidMiner (RM) versión 5.3.15. El caso de estudio considerado es la carrera Licenciatura en Ciencias de la Computación del Departamento Informática, Facultad de Ciencias Exactas Físicas y Naturales de La Universidad Nacional de San Juan.  Se destaca que el ISBN que aparece en esta base de datos asociado a la publicación, es al sólo efecto de poder incorporar el trabajo, dado que el ISBN  de la publicación está en trámite. Así mismo el paginado es al sólo efecto de su posterior transferencia al informe de proyectos.","palabras_clave":"Pertinencia-Planes de Estudio|Minería de Texto|RapidMiner|Carreras-Informática"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3440,"idioma_id":4,"titulo":"Benzyl-aminopurine (BAP) treatments delay cell wall degradation and softening, improving quality maintenance of refrigerated summer squash","resumen":"Round summer squash are harvested before reaching full maturity and even though they are highlyperishable, fruit postharvest handling is mostly based on storage at non-chilling temperatures. Find-ing complementary treatments minimizing deterioration and reducing postharvest losses would beextremely useful. In this work we evaluated the effect of postharvest cytokinin (CK) treatments on refrig-erated round soft rind squash. Fruit were harvested at commercial maturity and sprayed with 1 mmol L&#8722;1benzylaminopurine (BAP) or water (control) prior to storage at 5&#9702;C for 0, 13 or 25 days. Quality wasassessed upon removal from cold storage as well as after a 2 day shelf-life period at 20&#9702;C. CK-treatedfruit showed slower deterioration and dehydration and remained firmer than the control. BAP spraysdid not affect color, respiration or sugar-acid balance. The treatments prevented phenolic compoundaccumulation, and decreased pectin solubilization. By the end of the storage period BAP-treated squashhad higher levels (45%) of tightly-bound polyuronides than untreated controls, indicating a substantialdelay in cell wall dismantling. CK sprays also reduced neutral sugar solubilization from pectin-rich frac-tions, but no changes were found in the cross-linking glycans or cellulose. To our knowledge, this is thefirst work showing that CK can regulate pectin disassembly in developing fruit. Postharvest BAP sprayspreventing texture deterioration may be a simple treatment to complement refrigeration of round, softrind, summer squash.","palabras_clave":"CUCURBITS|CELL WALL|TEXTURE|FIRMNESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3441,"idioma_id":4,"titulo":"Stability of cosmological deflagration fronts","resumen":"In a cosmological first-order phase transition, bubbles of the stable phase nucleate and expand in the supercooled metastable phase. In many cases, the growth of bubbles reaches a stationary state, with bubble walls propagating as detonations or deflagrations. However, these hydrodynamical solutions may be unstable under corrugation of the interface. Such instability may drastically alter some of the cosmological consequences of the phase transition. Here, we study the hydrodynamical stability of deflagration fronts. We improve upon previous studies by making a more careful and detailed analysis. In particular, we take into account the fact that the equation of motion for the phase interface depends separately on the temperature and fluid velocity on each side of the wall. Fluid variables on each side of the wall are similar for weakly first-order phase transitions, but differ significantly for stronger phase transitions. As a consequence, we find that, for large enough supercooling, any subsonic wall velocity becomes unstable. Moreover, as the velocity approaches the speed of sound, perturbations become unstable on all wavelengths. For smaller supercooling and small wall velocities, our results agree with those of previous works. Essentially, perturbations on large wavelengths are unstable, unless the wall velocity is higher than a critical value. We also find a previously unobserved range of marginally unstable wavelengths. We analyse the dynamical relevance of the instabilities, and we estimate the characteristic time and length scales associated to their growth. We discuss the implications for the electroweak phase transition and its cosmological consequences.","palabras_clave":"ELECTROWEAK PHASE TRANSITION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3442,"idioma_id":4,"titulo":"Staphylococcus aureus chronic intramammary infection modifies protein expression of transforming growth factor beta (TGF-â) subfamily components during active involution","resumen":"The objectives of this study were to determine whether S. aureus chronic intramammary infection (IMI) influences protein expression of TGF-â subfamily components and collagen I and to examine the histomorphometric changes that occur in mammary stroma and parenchyma during active mammary gland involution. Twenty-one Holstein non-pregnant cows in late lactation either uninfected or with chronic natural S. aureus IMI were included in this study. Cows were slaughtered at 7, 14 and 21 d after cessation of milking and samples for immunohistochemical and morphometric analysis were taken. Protein expression of TGF-â1, TGF-â2 and TGF-â3 was significantly higher in chronically infected quarters than in uninfected controls at the three involution stages studied.  Immunostaining of TGF-âR1 and TGF-âR3 and collagen I was significantly higher in S. aureus-infected quarters than in uninfected controls at every involution time evaluated. The percentages of tissue area composed of parenchyma and intralobular stroma were significantly higher in S. aureus-infected than in uninfected quarters. Chronic S. aureus mastitis modifies protein expression of the three TGF-â isoforms and type 1 and 3 receptors, which was associated with changes directed to limit the scope  of inflammation and injury to the host.","palabras_clave":"Transforming growth factor beta|Staphylococcus aureus|mastitis|involution"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3443,"idioma_id":4,"titulo":"Searches for Large-Scale Anisotropy in the Arrival Directions of Cosmic Rays Detected above Energy of $10^{19}$ eV at the Pierre Auger Observatory and the Telescope Array","resumen":"Spherical harmonic moments are well-suited for capturing anisotropy at any scale in the flux of cosmic rays. An unambiguous measurement of the full set of spherical harmonic coefficients requires full-sky coverage. This can be achieved by combining data from observatories located in both the northern and southern hemispheres. To this end, a joint analysis using data recorded at the Telescope Array and the Pierre Auger Observatory above 10^19 eV is presented in this work. The resulting multipolar expansion of the flux of cosmic rays allows us to perform a series of anisotropy searches, and in particular to report on the angular power spectrum of cosmic rays above 10^19 eV. No significant deviation from isotropic expectations is found throughout the analyses performed. Upper limits on the amplitudes of the dipole and quadrupole moments are derived as a function of the direction in the sky, varying between 7% and 13% for the dipole and between 7% and 10% for a symmetric quadrupole.","palabras_clave":"ASTROPARTICLE PHYSICS|COSMIC RAYS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3444,"idioma_id":4,"titulo":"Analysis of the performance of a dehulling system for confectionary sunflower seeds","resumen":"Confectionary sunflower, which has a larger size and lower oil content than oilseed sunflower, has a considerable market, since it is used for birdfeed and human consumption. The characteristics of use of confectionary sunflower seeds require a dehulling process that is efficient in the removal of the hull and that also allows to obtain a product consisting mainly of whole kernels. Response surface methodology was used to determine an optimal combination of working conditions in the dehulling process of confectionary sunflower seeds. Optimization factors were impact speed, expressed in terms of the peripheral speed (28.3-41.9 m\/s), and moisture content of the seeds (4-14 %, dry basis). A rotatable central composite design was used to develop models for the responses (dehulling ability &#8210;DA&#8210; and percentage of whole kernels &#8210;WK). Applying the desirability function method, the optimal values of the factors were determined using maximum WK and maximum DA as criteria. The results of the optimization technique suggest that by dehulling Mycogen 9338 confectionary sunflower seeds at 12.3% db and 32.5 m\/s, the maximum values of DA and WK (72.6% and 63%, respectively) would be obtained. The moisture value defined as optimal determines a requirement of humidification of the seeds prior to dehulling, establishing the need for a technical and economic feasibility study.","palabras_clave":"Confectionary sunflower, |Dehulling|Response Surface Methodology|Whole kernels"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3445,"idioma_id":4,"titulo":"Molecular characterization and phenotyping study of beta thalassemia in Tucumán, Argentina","resumen":"The main hereditary hemoglobin (Hb) disorder in Argentina is b-thalassemia (b-thal). Molecular studies performed in the center of the country exhibited a marked prevalence of the codon 39 (C4T) and IVS-I-110 (G4A) mutations. The northwest region of Argentina has a different demographic history characterized by an important Spanish influx. Seventy-one b-thal carriers attending the Instituto de Bioqu&#305;´mica Aplicada, Tucuma´n, Argentina, were investigated for b-globin gene mutations by real-time polymerase chain reaction (RT-PCR). To examine the genotype-phenotype relationship, mean corpuscular volume (MCV), mean corpuscular Hb (MCH) and Hb A2 were measured. In order to recognize b-thal, Mentzer Index, Shine & Lal and Red Cell Distribution Width Index (RDWI), were calculated. The ethnic background of subjects revealed that 82.0% of the population was of Italian, Spanish and Arab origin. Seven mutations were detected: codon 39 (45.0%), IVS-I-1 (G4A) (22.5%), IVS-I-110 (16.3%), IVS-II-1  (G4A) (4.1%), IVS-I-1 (G4T) (2.0%), IVS-I-6 (T4C) (2.0%) and IVS-II-745 (G4C) (2.0%). In three families (6.1%), b-thal mutations were not determined. These results differed from other Argentinian studies because at present codon 39 and IVS-I-1 are the most prevalent; MCV, MCH and Hb A2 did not correlate with the type of mutation (b0\/b+). Values of MCV (67.0 fL) and Hb A2 (4.85%) were unable to discriminate between them. Significant differences (p50.05) in MCV, MCH and Shine & Lal were observed between the undetermined group and the three most common mutations. These data show different patterns of b-thal mutations in the center and northwest regions of Argentina. Differences might represent the influence of Spanish  immigration.","palabras_clave":"ARGENTINA|BETA THALASSEMIA MUTATIONS|GENOTYPE-PHENOTYPE CORRELATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3447,"idioma_id":5,"titulo":"Dilemas de la democracia (y el capitalismo) en la Argentina: transformaciones sociales y reconfiguraciones ideológicas. Parte II.","resumen":"Junto con la crisis económica global han resurgido nuevos desafíos para las sociedades democráticas. En el caso particular de América Latina, ha llegado a ser evidente que cualquier intento por avanzar con políticas democratizadoras en términos políticos, culturales y económicos debe lidiar con la herencia cultural de las reformas neoliberales, los cambios en la estructura social que éstas produjeron y un contexto internacional que se mueve en un sentido opuesto al de la soberanía de los poderes democráticos. En este trabajo presentamos una serie de análisis (resultado de una investigación empírica) que intentan plantear los desafíos que enfrenta la democracia en Argentina desde el punto de vista de las transformaciones de la estructura social y las reconfiguraciones ideológicas que las acompañaron.","palabras_clave":"Democracia|Capitalismo|Clases Sociales|ideologías"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3448,"idioma_id":4,"titulo":"A regional starter for higher quality wines: an Argentinean Patagonia experience","resumen":"The demands of an increasingly competitive international market suffering from oversupply, and consumer demand for new styles of wine, impose challenges to winemakers that require technological innovation. Within the productive chain, appropriate management of the yeast biota responsible for conducting the alcoholic fermentation is strategic to differentiate the character of wine. The objective of this study was to characterize the ability of a Patagonian Saccharomyces cerevisiae strain to drive red vinifications and to improve the quality of the regional wines.Pilot scale vinifications (200 L) were carried out in Pinot noir, Merlot and Malbec varieties, during three consecutive vintages (2012 to 2014). Sulfited musts industrially obtained were inoculated with S. cerevisiae ÑIF8-LVI, an autochthonous strain, (initial cellular density of 106 cel\/mL). Alcoholic fermentation (AF) was followed by ºBaumé and total reducing sugars, and implantation capacity was studied by viable counts in GPY agar and restriction profile analysis from mitochondrial DNA with Hinf I endonuclease. In all cases, assays with a S. cerevisiae F15 (Laffort), a commonly used commercial starter, were carried out as a comparison. When alcoholic fermentations were finished, wines were devatted and transferred to the 50 L tanks where spontaneous malolactic fermentation (MLF) developed at 20&#61617;2ºC. They were stabilized, clarificated, filtered and bottled. Quality was evaluated through physicochemical parameters (INV and enzymatic methods), sensorial analysis and consumer preference polls.Both indigenous and commercial starters were able to satisfactorily implant, yielding normal processes and products. However, S. cerevisiae ÑIF8 vinifications showed significantly faster kinetics than F15 controls and the oenological characteristics of these wines were significantly improved, allowing to obtain a higher score than controls in the sensorial evaluation and to be preferred for the consumers (paired-preference test p<0.05). These results reassure the oenological potential of S. cerevisiae ÑIF8 strain for the formulation of a regional starter culture already confirmed at laboratory scale.","palabras_clave":"onologia|starters|saccharomyces cerevisiae|fermentación alcoholica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3449,"idioma_id":4,"titulo":"Remediation of Phenanthrene-contaminated soil by simultaneous chemical and biological degradation processes","resumen":"Polycyclic aromatic hydrocarbons (PAHs) are  ubiquitous compounds with carcinogenic and\/or mutagenic  potential. To address the limitations of individual remediation  techniques and to achieve better PAH removal efficiencies, the  combination of chemical and biological treatments can be  used. The degradation of phenanthrene (chosen as a model  of PAH) by persulfate in freshly contaminated soil micro-  cosms was studied to assess its impact on the biodegradation  process and on soil properties. Soil microcosms contaminated  with 140 mg\/kg DRY SOIL of phenanthrene were treated with  different persulfate (PS) concentrations 0.86 ? 41.7 g\/kg DRY  SOIL and incubated for 28 days. Analyses of phenanthrene  and persulfate concentrations and soil pH were performed.  Cultivable heterotrophic bacterial count was carried out after  28 days of treatment. Genetic diversity analysis of the soil  microcosm bacterial community was performed by PCR am-  plification of bacterial 16S rDNA fragments followed by  denaturing gradient gel electrophoresis (DGGE). The addition  of  PS  in  low  concentrations  could  be  an  interesting  biostimulatory strategy that managed to shorten the lag phase  of the phenanthrene biological elimination, without negative  effects on the physicochemical and biological soil properties,  improving the remediation treatment.","palabras_clave":"Phenanthrene|Persulfate Treatment|Contaminated Soil| DGGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3450,"idioma_id":4,"titulo":"COLD AND WARM DRY MONTHS AND THE ASSOCIATED CIRCULATION IN THE HUMID AND SEMI-HUMID ARGENTINE REGION","resumen":"Abstract This paper studies the climatic conditions of  warm and cold dry months in the humid and semi-humid  Argentine region and some aspects of the regional circulation  related to these cases. The climatic analysis of warm  (temperatures above percentile 80) and cold (temperatures  below percentile 20) dry months is based on precipitation  and temperature data registered at reference stations over a  period of at least 70 years, while the associated circulation  is derived from daily data of geopotential height at 500 hPa  from NCEP-DOE Reanalysis 2 database. The reference  station for the center of the country registered a greater  number of warm dry months during both the warm season  (October?March) and the cold season (April?September),  whereas the reference stations in the north-east and centereast  showed differences depending on the time of the year,  with more cold dry months during the April?September  season and more warm dry months in the October?March  season. A classification of daily fields of geopotential  height anomalies at 500 hPa was used to analyze the  atmospheric circulation related to warm and cold dry  months. The circulation patterns were obtained by applying  principal component analysis and cluster analysis. Findings  show that some mid-level circulation patterns occur with a  significant different frequency during the warm dry months  or the cold dry months studied. Finally, cases of spatially  extended precipitation-deficit conditions (hereinafter  generalized droughts) were studied, noting dominant patterns  that are coherent with the previous results","palabras_clave":"DROUGHT|SYNOPTIC CIRCULATION|EXTREME TEMPERATURE|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3456,"idioma_id":4,"titulo":"Llama oviductal sperm reservoirs: involvement of bulbourethral glands","resumen":"The aim of this study was to elucidate the role of llama seminal plasma in the formation of oviductal sperm reservoirs. Female llamas with follicles in the mature phase were mated with a bulbourethral glands-removed male. Females mated with nonbulbourethral glands-removed males were used as control. Oviducts were obtained by surgery 24 h after mating. The uterotubal junction and isthmus were examined by scanning electron microscopy, and mucopolysaccharides were identified by Alcian blue staining. To know the proteins probably involved in sperm reservoir formation, SDS-PAGE of seminal plasma (8% and 18% resolving gel) was made. Spermatozoa only adhered to the oviductal mucosa surface of uterotubal junction of females mated with nonbulbourethral glands-removed males confirming that seminal plasma and, in particular, bulbourethral secretions are related with the oviductal sperm reservoir formation. Histological sections showed sperm in the lumen, immersed in substance, positive for acid mucopolysaccharides. Alcian blue staining of seminal plasma proteins SDS-PAGE showed a band of high molecular weight containing mucopolysaccharides, only present in nonbulbourethral glands-removed males. Bulbourethral glands would secrete at least eight different proteins that most likely participate in the process of sperm storage in the oviduct.","palabras_clave":"Llama|oviduct|sperm reservoir|seminal plasma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3536,"idioma_id":4,"titulo":"Can one single species challenge paradigms of salt marsh functioning?","resumen":"Over the history of ecology, well-established generalizations were refined or even changed after the appearance or consideration of new evidence. Here, we review results obtained in Southwestern Atlantic salt marshes (between southern Brazil &#8722;32° 1&#8242; S- and the Argentinean Patagonia &#8722;53° 48&#8242; S-). Most of these salt marshes are inhabited by the intertidal burrowing crab Neohelice granulata, a species that  influences many ecological processes through bioturbation and herbivory. The experimental evaluation of these processes shows that in some cases, the results were not consistent with generalizations and models of salt marsh ecological functioning.  However, this does not imply that the generalizations grounded mainly on the results from North American sites are not valid. In turn, we suggest that these apparently conflicting results emerged because two major processes, herbivory  and bioturbation, have been overlooked until recently.Thus, their relative contribution has not been included in the models of salt marsh functioning. In conclusion, we believe that there is a need for performing parallel and simultaneous  experiments comparing distant sites with varying environmental (i.e., abiotic and biotic) conditions to be able to uncover common processes and causes of contingencies. Particularly, Southwestern Atlantic salt marshes could lead the way in providing infOrmation to better incorporate herbivory and bioturbation into current models or paradigms about how salt marshes wORK.","palabras_clave":"SALT MARSH FUNCTIONING|BIOTURBATION|HERBIVORY|BURROWING CRAB"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3539,"idioma_id":4,"titulo":"DIFFERENTIAL EXPRESSION OF THE CHEMOKINE RECEPTOR FOR FRACTALKINE (CX3CR1) IN HUMAN MONOCYTES DURING DIFFERENTIATION","resumen":"Paper #CMI-2014-0155R  ABSTRACT  Circulating monocytes (Mo) may continuously repopulate macrophage (MAC) or dendritic  cell (DC) populations to maintain homeostasis. MAC and DCs are specialized cells that play  different and complementary immunological functions. Accordingly, they present distinct  migratory properties: whereas MAC largely remain in tissues, DC are capable of migrating  from peripheral tissues to lymphoid organs. The aim of this work was to analyze the  expression of the fractalkine receptor (CX3CR1) along the differentiation process, as a central  chemokine receptor involved in Mo recruitment in various tissues, in both homeostatic and  inflammatory conditions. Freshly isolated Mo express high levels of both CX3CR1 mRNA  and protein, whereas significant differences in CX3CR1-expression exist between DC and  MAC. CX3CR1 was rapidly down-regulated during Mo differentiation towards DC. On the  other hand, higher CX3CR1 membrane expression and mRNA levels were observed in MAC.  We also demonstrated an antagonistic regulatory capacity of interferon (IFN)-&#947; and  interleukin (IL)-4 upon CX3CR1 membrane expression during MAC activation through the  classical or alternative MAC pathway respectively. While IFN-&#947; inhibits the loss of CX3CR1  protein, IL-4 triggers a strong down-modulation of this receptor. This is the first report  demonstrating sequential and differential CX3CR1 modulation along Mo differentiation and  maturation.","palabras_clave":"CX3CR1|fractalquina|monocitos|regulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3540,"idioma_id":4,"titulo":"Electrochemical immunosensing using a nanostructured functional platform for determination of &#945;-zearalanol","resumen":"We describe an electrochemical immunosensor for the determination of the growth promoter &#945;-zearalanol in bovine serum. The sensing scheme is based on a nanocomposite consisting of gold nanoparticles electrodeposited on multi-walled carbon nanotubes that were modified with poly(vinylpyridine) through in-situ polymerization. The electrodeposition of the gold nanoparticles enlarges the surface available for immobilization of antibodies against &#945;-zearalanol. The nanocomposite film was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, and cyclic voltammetry. The calibration plot has a linear response in the concentrations range from 0.05 to 50 ng mL&#8722;1, and the detection limit is 16 pgmL&#8722;1. The time required for analysis is 12 min only which compares quite favorably with the time (90 min) required by the conventional ELISA. The method exhibits good selectivity, stability and reproducibility for detecting &#945;-zearalanol in the livestock production.","palabras_clave":"Electrochemical| immunosensing |growth promoter|livestock production"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3542,"idioma_id":4,"titulo":"On models of directed path graphs non rooted directed path graphs","resumen":"A directed path graph is the intersection graph of a family of&nbsp; directed subpaths of a directed tree. A rooted directed path graph&nbsp; is the intersection graph of a family of directed subpaths of a&nbsp; rooted tree. Clearly, rooted directed path graphs are&nbsp; directed path graphs. Several characterizations are known for&nbsp; directed path graphs: one by forbidden induced subgraphs and one by&nbsp; forbidden asteroids. It is an open problem to find such&nbsp; characterizations for rooted directed path graphs. With the purpose of proving&nbsp; knowledge in this direction,&nbsp; we show in this paper properties of&nbsp; directed path&nbsp; models that can not be rooted for chordal graphs with any leafage and&nbsp; with leafage four.&nbsp; Therefore, we prove that for leafage four directed path graphs minimally&nbsp;&nbsp; non rooted directed path graphs have a unique asteroidal quadruple, and can be characterized by the presence&nbsp;&nbsp; of certain type of asteroidal quadruples.","palabras_clave":"CHORDAL|ASTEROIDS|TREES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3543,"idioma_id":4,"titulo":"Investigation of the resonance-assisted hydrogen bond in model &#946;-diketones through localized molecular orbital analysis of the spin?spin coupling constants related to the O?H&#8201;·&#8201;·&#8201;·&#8201;O hydrogen bond","resumen":"The resonance-assisted hydrogen bond (HB) phenomenon has been studied theoretically by a localized molecular orbital (LMO) decomposition of the spin?spin coupling constants between atoms either involved or close to the O?H···O system of some &#946;-diketones and their saturated counterparts. The analysis, carried out at the level of the second-order polarization propagator approximation, shows that the contributions in terms of LMO to the paramagnetic spin orbital and the spin dipolar Ramsey terms proof the importance of the delocalized &#960;-electron structure supporting the idea of the existence of the resonance-assisted HB phenomenon phenomenon. The LMO contributions to the Fermi contact term indicate mainly the presence of the HB that may or not be linked to the &#960;-electrons.","palabras_clave":"NMR|17O; 1H; 13C|Ramsey contribution to SSCC|resonance-assisted hydrogen bond|localized molecular orbitals"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3545,"idioma_id":4,"titulo":"Bone morphogenetic proteins (BMPs) in the bovine oviduct: Differential expression of BMP-5 in the isthmus during the estrous cycle","resumen":"Bone morphogenetic proteins (BMPs) play a crucial role in mammalian reproduction, but little is known about their expression and function in the oviduct, where preimplantation events take place. In the present study, messenger RNA (mRNA) expression of BMPs was examined by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR)  in bovine oviduct epithelial cells obtained from ampulla and isthmus at different stages of the estrous cycle. Expression of BMP-2, -3, -4, -7, -10 and -15 mRNA was detected in epithelial cells of both anatomic regions, whereas BMP-5 mRNA was specifically expressed in isthmus epithelial cells throughout the estrous cycle. High expression levels  for BMP-5 and for BMP-2, -4, and -7 mRNA were observed during the preovulatory stage. Considering the region-specific gene expression of BMP-5, its protein localization in the oviduct and its presence in the oviductal fluid were evaluated by immunohistochemistry andWestern blot analysis. BMP-5 protein staining was observed in isthmus sections with a  more intense signal in the luminal epithelial cell layer. In addition, a 21 kDa protein corresponding to the BMP-5 mature monomeric form was detected in bovine oviductal fluid throughout the estrous cycle. In conclusion, these results demonstrate that different members of the BMP family are expressed in the bovine oviduct during the estrous cycle,  and reveal that BMP-5 is differentially expressed in the isthmus. The expression of this factor in the oviduct epithelium and its presence in the luminal fluid suggest a possible action of BMP-5 as a new autocrine and\/or paracrine regulator of the reproductive events that occur in the bovine oviductal environment.","palabras_clave":"BMP|TGF-B|CATTLE|OVIDUCT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3546,"idioma_id":4,"titulo":"FoxO3a nuclear localization and its association with &#946;-catenin and  Smads in IFN-&#945;-treated hepatocellular carcinoma cell lines","resumen":"Interferon-&#945;2b (IFN-&#945;2b) reduces proliferation and increases apoptosis in hepatocellular carcinoma cells by decreasing &#946;-catenin\/TCF4\/Smads interaction. Forkhead box O-class 3a (FoxO3a) participates in proliferation and apoptosis and interacts with &#946;-catenin and Smads. FoxO3a is inhibited by Akt, I&#954;B kinase &#946; (IKK&#946;), and extracellular-signal-regulated kinase (Erk), which promote FoxO3a sequestration in the cytosol, and accumulates in the nucleus upon phosphorylation by c-Jun N-terminal kinase (JNK) and p38 mitogen-activated kinase (p38 MAPK). We analyzed FoxO3a subcellular localization, the participating kinases, FoxO3a\/&#946;-catenin\/Smads association, and FoxO3a target gene expression in IFN-&#945;2b-stimulated HepG2\/C3A and Huh7 cells. Total FoxO3a and Akt-phosphorylated FoxO3a levels decreased in the cytosol, whereas total FoxO3a levels increased in the nucleus upon IFN-&#945;2b stimulus. IFN-&#945;2b reduced Akt, IKK&#946;, and Erk activation, and increased JNK and p38 MAPK activation. p38 MAPK inhibition blocked IFN-&#945;2b-induced FoxO3a nuclear localization. IFN-&#945;2b enhanced FoxO3a association with &#946;-catenin and Smad2\/3\/7. Two-step coimmunoprecipitation experiments suggest that these proteins coexist in the same complex. The expression of several FoxO3a target genes increased with IFN-&#945;2b. FoxO3a knockdown prevented the induction of these genes, suggesting that FoxO3a acts as mediator of IFN-&#945;2b action. Results suggest a &#946;-catenin\/Smads switch from TCF4 to FoxO3a. Such events would contribute to the IFN-&#945;2b-mediated effects on cellular proliferation and apoptosis. These results demonstrate new mechanisms for IFN-&#945; action, showing the importance of its application in antitumorigenic therapies.","palabras_clave":"FoxO3a|Hepatocarcinoma|beta-catenin|IFN-alpha"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3547,"idioma_id":4,"titulo":"In vitro activity of natural phenolic compounds against fluconazole resistant Candida species: a quantitative structure activity relationship analysis.","resumen":"Aims: To evaluate the antifungal activity and to analyse the structure?activityrelationship of eleven natural phenolic compounds against four Candidaspecies which are resistant to fluconazole. Methods and Results: Four different species of Candida isolates were used:Candida albicans, Candida krusei, Candida tropicalis and Candida dubliniensis.The phenolic compound carvacrol showed the highest anti-Candida bioactivity,followed by thymol and isoeugenol. The obtained minimum inhibitoryconcentration (MIC) values obtained were used in a quantitative structure?activity relationship (QSAR) analysis where the electronic, steric, thermodynamic and topological descriptors served as dependent variables. According to the descriptors obtained in this QSAR study, the antifungal activity of phenols has a first action specific character which is based on their interaction with plasma or mitochondrial membranes. The second action is based on a steric descriptor?the maximal and minimal projection of the area?which could explain the inability of some phenolic compounds to be biotransformed to quinones methylene by Candida species.Conclusions: According to the descriptors obtained in this QSAR study, theanti-Candida activity of ortho-substituted phenols is due to more than oneaction mechanism. The anti-Candida activity of phenolic compounds can bepredicted by their molecular properties and structural characteristics.Significance and Impact of the Study: These results could be employed topredict the anti-Candida activity of new phenolic compounds in the search fornew alternatives or complementary therapies to combat against candidiasis.","palabras_clave":"ANTICANDIDAL ACTIVITY|CANDIDA ALBICANS|CANDIDA DUBLINIESIS|CANDIDA KRUSEI|CANDIDA TROPICALIS|NATURAL PHENOLS|QUANTITATIVE STRUCTURE-ACTIVITY RELANTIONSHIP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3548,"idioma_id":4,"titulo":"Formation, Characterization, and Stability of Methaneselenolate  Monolayers on Au(111): An Electrochemical High-Resolution  Photoemission Spectroscopy and DFT Study","resumen":"We investigated the mechanism of formation and stability of self-assembled monolayers (SAMs) of methaneselenolate on Au(111) prepared by the immersion method in ethanolic solutions of dimethyl diselenide (DMDSe). The adsorbed species were characterized by electrochemical measurements and high-resolution photoelectron spectroscopy (HR-XPS). The importance of the headgroup on formation mechanism and the stability of the SAMs was addressed by comparatively studying methaneselenolate (MSe) and methanethiolate (MT) monolayers. Density Functional Theory (DFT) calculations were performed to identify the elementary reaction steps in the mechanisms of formation and decomposition of the monolayers. Reductive desorption and HR-XPS measurements indicated that a MSe monolayer is formed at short immersion times by the cleavage of the Se?Se bond of DMDSe. However, the monolayer decomposes at long immersion times at room temperature, as evidenced by the appearance of atomic Se on the surface. The decomposition is more pronounced for MSe than for MT monolayers. The MSe monolayer stability can be greatly improved by two modifications in the preparation method: immersion at low temperatures (&#8722;20 °C) and the addition of a reducing agent to the forming solution.","palabras_clave":"Photoelectron spectroscopy| Selenium compounds|Self assembled monolayers|X ray photoelectron spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3549,"idioma_id":4,"titulo":"Rhomboid family genes expression profiling in breast normal tissue and tumor samples","resumen":"Abstract Rhomboid is an evolutionary conserved and functionallydiversified group of proteins composed of proteolyticallyactive and inactive members that are involved in themodulation of multiple biological processes such as epidermalgrowth factor receptor signaling pathway, endoplasmic reticulum-associated degradation, cell death, and proliferation.Recently, several human rhomboid genes have been associatedwith the development of chronic myeloid leukemia andpituitary, colorectal, ovarian, and breast cancers. In this study,we evaluated the mRNA and protein expression profiles ofrhomboid genes in cancer cell lines and breast tissue\/tumorsamples. In silico analysis of publicly available gene expressiondatasets showed that different rhomboid genes are specificallyexpressed according to the breast cancer intrinsicsubtypes. Quantitative reverse transcription?polymerase chainreaction (RT-PCR) analysis showed a significant RHBDD2mRNA overexpression in advanced breast cancer comparedwith normal tissue samples (p =0.012). In addition, we foundthat RHBDL2 and PARL mRNA expression was associatedwith a low\/intermediate histologic tumor grade (p =0.024 andp =0.015, respectively). Immunohistochemistry analysisshowed a significant increase of RHBDD2 protein expressionin association with breast cancer samples negative for progesteronereceptor (p =0.015). Moreover, protein expressionanalysis corroborated the quantitative RT-PCR results, indicatingthat breast primary tumors belonging to patients with amore disseminated disease expressed significantly increasedlevels of RHBDD2 protein compared with less disseminatedtumors (p =0.01).","palabras_clave":"cáncer de mama|Romboides|perfil génico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3550,"idioma_id":4,"titulo":"PHARMACOKINETIC BEHAVIOUR OF ENROFLOXACIN AND ITS METABOLITE CIPROFLOXACIN IN URUTU PIT VIPERS (BOTHROPS ALTERNATUS) AFTER INTRAMUSCULAR ADMINISTRATION","resumen":"Enrofloxacin is widely used in veterinary medicine and is an important alternative to treating bacterial infections, which play an important role as causes of disease and death in captive snakes. Its extralabel use in nontraditional species has been related to its excellent pharmacokinetic and antimicrobial characteristics.This can be demonstrated by its activity against gram-negative organisms implicated in serious infectious diseases of reptile species with a rapid and concentration-dependent bactericidal effect and a large volume of distribution. Pharmacokinetic parameters for enrofloxacin were investigated in seven urutu pit vipers (Bothrops alternatus),following intramuscular injections of 10 mg\/kg. The plasma concentrations of enrofloxacin and its metabolite, ciprofloxacin, were measured using high-performance liquid chromatography. Blood samples were collected from the ventral coccygeal veins at 0.5, 1, 2, 4, 8, 12, 24, 36, 48, 72, 96, 108, and 168 hr. The kinetic behavior was characterized by a relatively slow absorption (time of maximal plasma concentration ¼ 4.50 6 3.45 hr) with peak plasma concentration of 4.81 6 1.12 lg\/ml. The long half-life during the terminal elimination phase (t1\/2k¼27.91 6 7.55 hr) of enrofloxacin after intramuscular administration, calculated in the present study, could suggest that the antibiotic is eliminated relatively slowly and\/or the presence of a slow absorption in urutu pit vipers.Ciprofloxacin reached a peak plasma concentration of 0.35 lg\/ml at 13.45 hr, and the fraction of enrofloxacin metabolized to ciprofloxacin was 13.06%. If enrofloxacin?s minimum inhibitory concentration (MIC90) values of 0.5 lg\/ml were used, the ratios AUCeþc : MIC90 (276 6 67 hr) and Cmaxeþc : MIC90 (10 6 2) reach the proposedthreshold values (125 hr and 10, respectively) for optimized efficacy and minimized resistance development when treating infections caused by Pseudomonas. The administration of 10 mg\/kg of enrofloxacin by the i.m. route should be considered to be a judicious choice in urutu pit vipers against infections caused by microorganisms withMIC values 0.5 lg\/ml. For less susceptible bacteria, a dose increase and\/or an interval reduction should be evaluated.","palabras_clave":"enrofloxacin|PK|Bothrops alternatus"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3551,"idioma_id":5,"titulo":"Reconstrucción de la vegetación posglacial y su relación con el ascenso relativo del nivel del mar en el extremo este del canal Beagle, Tierra del Fuego, Argentina","resumen":"A partir del análisis polínico de una turbera de Donatia-Astelia ubicada en Punta Moat (Moat-2; 54° 58´ 50´´S, 66° 44´ 10´´O; 40 m s.n.m), E del Canal Beagle, y de modelos digitales de terreno (SRTM) vinculados a la curva de ascenso del mar postglacial, se reconstruye la evolución paleogeográfica y la vegetación desde el Último Máximo Glacial (UMG, ca. 25 ka cal AP) hasta el Holoceno medio (5.000 años cal AP). La evolución de las comunidades vegetales en el extremo E del Canal Beagle coincide en líneas generales con el modelo regional de instalación postglacial de la vegetación en las áreas desprovistas de hielo del S de Tierra del Fuego. Este modelo plantea la sucesión de comunidades pioneras graminosas y arbustivas propias de la estepa, el ecotono bosque-estepa y el bosque de Nothofagus. Con anterioridad a los 17.700 años cal AP, el inicio de la deglaciación en Punta Moat y el retiro de los paleoglaciares alpinos hacia las cabeceras de las sierras de Lucio López propiciaron la formación de una planicie aluvial con cursos de agua que fluían en dirección perpendicular hacia el actual canal. Durante el Holoceno temprano (11.500-8.000 años cal AP), la vegetación fue similar a la que se desarrolló en los sectores occidental y central del Canal Beagle. Sin embargo, la influencia del ascenso relativo del nivel del mar y la consecuente disponibilidad de humedad ambiental favoreció el desarrollo temprano del bosque de Nothofagus en Punta Moat, y a los 9.500 años cal AP, el paisaje ya presentaba las características de un bosque denso. En el ámbito de la turbera, el aumento en la humedad efectiva propició el desarrollo de turberas mixtas de Sphagnum y plantas en cojín, con elementos florísticos propios de la Tundra Magallánica, por el efecto del spray marino y como consecuencia de la apertura de canales marinos y formación de las islas Picton y Nueva. Hacia los ca. 7.000 años cal AP en Punta Moat se establecen las condiciones paleogeográficas actuales con el desarrollo del Bosque Magallánico Siempreverde y la vegetación de la Tundra Magallánica.","palabras_clave":"PALINOLOGÍA|PALEOGEOGRAFÍA|AMBIENTE POSTGLACIAL|CANAL BEAGLE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3552,"idioma_id":4,"titulo":"Stereoselective one-pot synthesis of &#946;-alkylsulfide enol esters. Base-triggered rearrangement under mild conditions","resumen":"A stereoselective one-pot procedure was developed to prepare S-substituted (Z)-enol esters through a base-triggered rearrangement. This transition metal-free multicomponent approach can be performed under an air atmosphere at room temperature, tolerates a wide set of chemical functionalities and gener- ally a&#64256;ords high isolated yields. The (Z)-selectivity arises from the [1,4]-S- toO-acyl migration.","palabras_clave":"SYNTHESIS|STEREOSELECTIVE|ENOL-ESTER|MULTICOMPONENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3553,"idioma_id":4,"titulo":"Hexachlorobenzene induces TGF-&#946;1 expression, which is a regulator of p27 and cyclin D1 modifications.","resumen":"Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. In this  study we have demonstrated that HCB induced loss of cell viability and alterations in cell cycle regulation  in FRTL-5 rat thyroid cells. Analysis of cell cycle distribution by  flow cytometric analysis demonstrated  that HCB induced cell cycle arrest at G2\/M and at G0\/G1 phase, inhibiting cell cycle progression at the  G1\/S phase, after 24 h and 72 h of treatment.  HCB-treatment resulted in an increase in transforming growth factor-beta (TGF-b1) mRNA levels, a  negative regulator of cell growth in thyroid epithelial cells. Time-dependent studies showed that both  cytosolic and nuclear p27 protein levels were increased by 5 mM HCB. After 24 h of treatment, total p27 in  whole cells lysate was increased. Dose-dependent studies, demonstrated that HCB (0.005, 0.05, 0.5 and  5 mM) increased p27, both in the cytosol and nucleus. HCB (5 mM) induced a concomitant decrease in  nuclear cyclin D1 protein levels, in a time-dependent manner. We have also demonstrated that  TGF-b1 Smad signaling is involved in HCB-induced alterations of p27 and cyclin D1 protein levels. On the  other hand, ERK1\/2 activation is not involved in the alteration of cell cycle regulatory proteins","palabras_clave":"HEXACHLOROBENZENE|TGFBETA-1|CELL CYCLE|p27|CYCLIN D1|CELL PROLIFERATION|FRTL-5 RAT THYROID CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3554,"idioma_id":5,"titulo":"Explorando Temperaturas Máximas y Mínimas en diferentes reanálisis. Parte 2: Variabilidad en diferentes escalas temporales","resumen":"Con la motivación de que a menudo se emplean reanálisis para estudiar el clima regional aun cuando no es clara la magnitud de sus errores, en este artículo se explora la incertidumbre inherente a utilizar datos de reanálisis de temperatura máxima y mínima en el sudeste de Sudamérica. Se comparan campos medios observacionales de TX (verano) y TN (invierno)(Tencer et al., 2011), tres diferentes reanálisis multidecádicos (NCEP, ERA40 y 20CR) y cuatro modelos climáticos regionales (LMDZ, PROMES, RCA y REMO). El reanálisis más aceptable para representar el campo medio de TX es ERA40, mientras que NCEP es el más aceptable para TN. El error del  ensemble de reanálisis presenta magnitudes similares para ambas variables (errores menores a 4°C),pero la dispersión entre los reanálisis individuales es mayor en verano. La mayor dispersión entre reanálisis se encuentra en el centro de la Argentina en esa estación. Se analizó también el balance de energía en superficie para los diferentes reanálisis, encontrándose que los procesos intervinientes en este balance impactan directamente sobre la temperatura. Los errores en la temperatura están, por lo tanto, en parte vinculados con errores en la determinación de los flujos de calor sensible y latente así como de la radiación neta.  La capacidad de los reanálisis y de los modelos regionales para representar la distribución geográfica de TX y TN se analizó mediante diagramas de Taylor. Los ensembles de reanálisis o de modelos regionales suelen tener mejores estadísticos en estos diagramas que los reanálisis o  modelos individuales. Además, los estadísticos exhibidos en los diagramas de Taylor sugieren que los errores en la distribución geográfica de las anomalías espaciales de temperatura tienen una magnitud similar para los reanálisis y para los modelos regionales analizados.","palabras_clave":"temperatura máxima|temperatura mínima|datos en puntos de reticulado|reanálisis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3555,"idioma_id":4,"titulo":"Determining the molecular basis for the pH-dependent interaction between 2 0 -deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states","resumen":"Interaction between norharmane and three different 2´-deoxynucleotides (dNMP) (2´-deoxyguanosine 5´-monophosphate (dGMP), 2´-deoxyadenosine 5´-monophosphate (dAMP) and 2´-deoxycytidine 5´-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and 1H-NMR spectroscopy and in the first electronic excited state with steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane\/dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane.","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":3556,"idioma_id":4,"titulo":"Characterization of albendazole-randomly methylated-&#946;-cyclodextrin inclusion complex and in vivo evaluation of its antihelmitic activity in a murine model of trichinellosis","resumen":"Albendazole is a benzimidazole carbamate extensively used in oral chemotherapy against intestinal parasites, due to its broad spectrum activity, good tolerance and low cost. However, the drug has the disadvantage of poor bioavailability due to its very low solubility in water; as a consequence, a very active area of research focuses on the development of new pharmaceutical formulations to increase its solubility, dissolution rate, and bioavailability. The primary objective of this study was to prepare randomly methylated beta-cyclodextrins inclusion complexes to increase albendazole dissolution rate, in order to enhance its antiparasitic activity. This formulation therapeutic efficacy was contrasted with that of the pure drug by treating Trichinella spiralis infected mice during the intestinal phase of the parasite cycle, on days five and six post-infection. This protocol significantly decreased muscle larval burden measured in the parenteral stage on day 30 post-infection, when compared with the untreated control. Thus, it could be demonstrated that the inclusion complexes improve the in vivo therapeutic activity of albendazole.","palabras_clave":"PARASITIC DISEASES|SOLUBILITY|TRICHINELLOSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":4421,"idioma_id":5,"titulo":"Evaluación  Genética de Reproductores Holando Argentino","resumen":"La presente publicación se enmarcó dentro de las actividades establecidas en el Convenio Marco y Carta Acuerdo firmados entre la Asociación Criadores de Holando Argentino y la Facultad de Ciencias Veterinarias de la Universidad Nacional del Centro de la Provincia de Buenos Aires. Conforme a lo estipulado en el Decreto N&#61616; 688\/81 con Resolución del 22 de agosto de 1982 y Expediente N&#61616; 2644\/82 de la Secretaría de Agricultura, Ganadería, Pesca y Alimentación del Gobierno de la República Argentina. La Asociación Criadores de Holando Argentino (ACHA) y la Facultad de Ciencias Veterinarias de la Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), mediante, el Área de Mejoramiento Genético del Departamento de Producción Animal y el Área de Bioestadística publicaron esta revista con las evaluaciones genéticas de los reproductores Holando Argentino. Las evaluaciones genéticas fueron realizadas mediante el método BLUP, Modelo Animal. Los caracteres productivos que se evaluaron fueron: Producción de Kg. de leche, Producción de Kg. de grasa, Porcentaje de grasa, Producción de Kg. de proteína y Porcentaje de proteína. La evaluación genética por producción consideró los datos del Control Lechero Oficial disponibles desde el 1° de Enero de 1988 al 30 de Abril de 2014. Se utilizaron 709.965 lactancias terminadas o en curso con una duración igual o superior a los 305 días, correspondientes a 430.536 vacas. El número de toros evaluados, con hijas con dato, fue 6.598. Para la obtención de los valores genéticos se tuvo en cuenta la información que aportaron los familiares, mediante la genealogía, y se incorporaron en el modelo los siguientes efectos fijos y aleatorios: Manejo, Mes de parto, Número de lactancia y edad, y Efecto ambiental permanente y Animal. Los valores genéticos se estandarizaron a una base común y se expresaron como Habilidad de Transmisión Predicha (HTP). Los caracteres morfológicos que se evaluaron correspondieron a 15 caracteres lineales principales y 5 generales: estatura, angulosidad, pecho, lomo, declive de grupa, separación de isquiones, ángulo de pezuña, calidad de hueso, patas vistas de costado, textura de ubre, inserción anterior, altura inserción posterior, ligamento medio, colocación pezones anteriores, colocación pezones posteriores, puntaje final, grupa, sistema mamario, patas y pezuñas y fortaleza lechera. La evaluación genética por morfología consideró 244.799 calificaciones realizadas por la Asociación Criadores de Holando Argentino (ACHA) mediante el Método Lineal. Se utilizaron calificaciones disponibles desde el 1° de Enero de 1988 al 30 de Abril de 2014. Fueron evaluados 7.458 toros. Los valores genéticos se estandarizaron a una base común y se expresaron como Habilidad de Transmisión Estandarizada (HTE); de esta manera todos los caracteres están presentados en una misma escala de variación. Los efectos no genéticos considerados en el modelo fueron: Rodeo-fecha de calificación, Número de lactancia y edad al momento de la calificación y Estado de lactancia en el momento de la calificación, incorporando al animal como efecto aleatorio. El carácter reproductivo evaluado fue Tasa de preñez de las hijas (días abiertos transformados). La evaluación genética por reproducción se basó en los datos de días abiertos del Control Lechero Oficial disponibles desde el 1° de Enero de 1988 al 30 de Abril de 2014. Para la obtención de los valores genéticos se utilizaron 556.658 lactancias terminadas o en curso con una duración igual o superior a los 305 días, correspondientes a 338.364 vacas. El número de toros evaluados, con hijas con dato, fue 5.884. En el modelo se consideraron los efectos fijos y aleatorios Manejo, Mes de parto, Número de lactancia y edad, y Efecto ambiental permanente y Animal. Los resultados de la evaluación genética por el caracter Tasa de Preñez de las Hijas, de la misma manera que para los caracteres de producción, se publicaron como Habilidad de Transmisión Predicha (HTP) desviados de la base genética establecida. Su valor se interpreta como el porcentaje de vacas vacías que se preñan por período de 21 días. Por lo tanto, es un porcentaje que indica la habilidad de las hijas de cada toro evaluado para preñarse. Asimismo, se elaboró un índice denominado IPM. El IPM es un índice desarrollado por la Asociación Criadores de Holando Argentino con el objetivo de brindar un valor genético que combina las características de producción, tipo y reproducción de relevancia en el sistema de producción nacional. La fórmula de cálculo, con los pesos relativos, fue la siguiente:&nbsp; IPM: 5 x [(33xP\/DEP)+(11xL\/DEL)+(11xG\/DEG)+(19,25xSM\/1)+(8,75xPP\/1)+(5,25xGR\/1)?(1,75xES\/1)+(10xTPH\/DET)].&nbsp;&nbsp; Donde P: kg. de proteína. DEP: Desvío estándar para Kg. de proteína (4,8 kg.). L: kg. de leche. DEL: Desvío estándar para Kg. de leche (152,4 kg.). G: kg. de grasa. DEG: Desvío estándar para Kg. de grasa (5,2 kg.). SM: Sistema mamario. PP: Patas y pezuñas. GR: Grupa. ES: Estatura. 1: Desvío estándar de las características de tipo. TPH: Tasa de preñez de las hijas. DET: Desvío estándar para tasa de preñez de las hijas (0,50 %). Los valores mínimo, máximo, promedio y desvío estándar observados para la población de toros evaluados en los distintos caracteres fueron: -835, 676, 29±153,7 para kg de leche, -18, 25, 1,30±5,0 para kg de grasa, -0,28, 0,24, -0,02±0,04 para porcentaje de grasa, -25, 23, 0,97±4,9 para kg de proteína, -0,16, 0,13, -0,01±0,02 para porcentaje de proteína, -4,67, 2,73, -0,26±1,07 para puntaje final, -2,9, 3,4, -0,3±0,6 para tasa de preñez de las hijas y -983, 1.169, 97±301,0 para IPM. Los valores para la población de hembras evaluadas fueron: -808, 922, -11,6±157,4 para kg de leche, -29, 34, -0,4±5,3 para kg de grasa, -0,35, 0,32, -0,02±0,04 para porcentaje de grasa, -27, 31, -0,5±5,0 para kg de proteína, -0,27, 0,18, -0,01±0,02 para porcentaje de proteína, -6,87, 2,96, -0,40±0,99 para puntaje final, -2,3, 3,2, 0,01±0,50 para tasa de preñez de las hijas y -1.514, 1.842, 40±314,3 para IPM.","palabras_clave":"EVALUACION GENETICA|BOVINOS DE LECHE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":8457,"idioma_id":5,"titulo":"Cuadernos del Historia del Arte.","resumen":"El Instituto publica los Cuadernos de Historia del Arte, (a partir de 1961 y continúan) para dar a conocer el resultado de las diversas investigaciones que se realizan en su ámbito. Además cuenta con la colaboración tanto de sus integrantes como de Profesores de otras especialidades de la Facultad y de calificados investigadores argentinos y extranjeros.  Tiene un importante canje con unidades académicas y prestigiosas instituciones dentro y fuera del país.","palabras_clave":"HISTORIA DEL ARTE REGIONAL|HISTORIA DEL ARTE|ARTES VISUALES |INVESTIGACIÓN ARTÍSTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":8889,"idioma_id":5,"titulo":"La dimensión formal del aspecto de la perspectiva tipológica: estrategias gramaticales y léxicas","resumen":"El aspecto es frecuentemente expresado por afijos y adverbios, una tendencia debidamente registrada en la literatura (Van Valin & LaPolla 1997; Cinque 1999). La evidencia translingüística muestra, sin embargo, que hay formas que escapan a esta caracterización, como son las construcciones multiverbales tales como las construcciones de verbos seriales y las construcciones converbales (Haspelmath 1995; Bisang 1995; Aihkenvald 2006). Para capturar el espectro fenómenos de expresión formal del aspecto se propone la Hipótesis de las Estrategias Prototípicas para la Expresión Formal del Aspecto, que sostiene que a) el aspecto se expresa prototípicamente mediante una estrategia gramatical (afijos) y\/o léxica (adverbios), entendidos como extremos de un continnum; y b) las construcciones multiverbales que expresan aspecto se aproximan a alguna de estrategias mediante i) la gramaticalización de uno de sus elementos, o ii) la recategorización de uno de sus elementos como adverbio. El artículo presenta evidencia tipológicamente diversa para intentar validar las generalizaciones de la hipótesis. Para ello se emplean datos de lenguas sudamericanas: mapudungun (aislada), toba (guaycurú), mocoví (guaycurú), guaraní paraguayo (tupí-guaraní) y vilela (filiación en discusión); se discuten ejemplos del español también. Se concluye que en el gradiente comprendido entre adverbios y afijos se ubican elementos verbales.","palabras_clave":"ASPECTO|GRAMATICALIZACIÓN|RECATEGORIZACIÓN|LENGUAS SUDAMERICANAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":9816,"idioma_id":5,"titulo":"EVALUACIÓN DE LA DISTRIBUCIÓN DE COMPUESTOS FENÓLICOS EN LAS FASES DEL ALPERUJO: APORTE A SU MANEJO","resumen":"Los residuos de la industria aceitera del olivo representan un problema ambiental importante ya que se generan grandes cantidades en cortos períodos de tiempo. Argentina se ubica como el principal productor de aceite de oliva de América del Sur, posee más de 100.000 hectáreas implantadas con olivos. En la campaña 2011 se produjeron alrededor de 200000 t de aceite de oliva y se generaronsimultáneamente cerca de 800000 t de alperujo, un material constituido por la pulpa, piel, carozo y agua de vegetación de la aceituna después de su industrialización, por el método de dos fases.La propuesta de manejo consiste en tratar al alperujo como materia prima y no como residuo. se concluye claramente que la pulpa proveniente del alperujo arrastra alrededor del 80 % de los compuestos fenólicos presentes en la aceituna.El contenido fenólico del agua de vegetación y su aptitud para su re-utilización en la propia industria y\/ó, previo tratamiento, para usos agrícolas.","palabras_clave":"ANTIOXIDANTES |POLIFENOLES|RESIDUOS |OLIVICOLAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":12501,"idioma_id":5,"titulo":"Bull Rockett, Héctor Germán Oesterheld y la imaginación técnica popular en la Argentina de mediados del siglo XX","resumen":"El presente trabajo buscará describir y analizar los imaginarios científico-técnicos presentes en los guiones de Héctor Germán Oesterheld para la serie Bull Rockett. La misma incluyó historietas en episodios continuados en la revista Misterix, historietas completas en Super Misterix y adaptaciones noveladas de dichas aventuras publicadas por la Editorial Frontera. Promocionada como ?la historieta científica? y de amplio éxito de ventas en plena ?edad de oro? de la historieta argentina, esta fuente ofrece una oportunidad privilegiada para indagar sobre la construcción y circulación de ideas, motivos e imágenes populares sobre los adelantos, polémicas, mitos y ?misterios? científicos y tecnológicos de mediados del siglo XX argentino. La formación académica de Oesterheld, así como su experiencia en la divulgación científica, le permitieron compatibilizar exitosamente estas instancias de diálogo con el imaginario técnico popular y las lógicas de la industria del entretenimiento.","palabras_clave":"OESTERHELD|IMAGINACIÓN TÉCNICA POPULAR|HISTORIETA|PERONISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":13807,"idioma_id":4,"titulo":"Factor Structure of the Torrance Tests of Creative Thinking Verbal Form B in a Spanish-speaking Population","resumen":"The objective of this study was to compare, through a Confirmatory Factor Analysis (CFA), two different theoretical models that explain the operationalized creativity construct with the Verbal Torrance Tests of Creative Thinking (TTCT), Form B. Model 1 is represented by 6 factors which correspond to each activity and its respective indicators while Model 2 is integrated by 3 factors which correspond to each TTCT ability (i.e., Fluency, Originality, and Flexibility) and the corresponding indicators for each variable. The study was carried out with a sample consisting of 432 Spanish speaking youngsters of both sexes aged 15 to 26. According to the research findings, the model which showed the most satisfactory fit identifies six correlated factors that correspond to each of the activities proposed (Chi2 = 414.48; df = 116; Chi2\/df = 3.57; GFI =.90, NFI =.95; CFI = .96 y RMSEA =.077). These results are discussed according to its psychometric implications for the construct assessment in different fields.","palabras_clave":"CREATIVITY|ASSESSMENT|CONFIRMATORY FACTOR ANALYSIS|TORRANCE TESTS OF CREATIVE THINKING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":16052,"idioma_id":5,"titulo":"UTILIDAD DE LAS GUÍAS DE TOKYO EN EL DIAGNÓSTICO DE COLECISTITIS AGUDA. (Correlación anatomopatológica)","resumen":"---","palabras_clave":"COLECISTITIS AGUDA|GUIAS DE TOKYO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":16404,"idioma_id":4,"titulo":"SOPHIE velocimetry of Kepler transit candidates. XVII. The physical properties of giant exoplanets within 400 days of period","resumen":"Context. Hot Jupiters are still a fascinating exoplanet population that presents a diversity we are still far from understanding. High-precision photometric observations combined with radial velocity measurements give us a unique opportunity to constrain their properties better, on both their internal structure and their atmospheric bulk properties.  Aims. We initiated a follow-up program of Kepler-released planet candidates with the goal of confirming the planetary nature of a number of them through radial velocity measurements. For those that successfully passed the radial velocity screening, we furthermore performed a detailed exploration of their properties to characterize the systems. As a byproduct, these systematic observations allow us to consolidate the exoplanets? occurrence rate.  Methods. We performed a complete analysis of the Kepler-412 system, listed as planet candidate KOI-202 in the Kepler catalog, by combining the Kepler observations from Q1 to Q15, to ground-based spectroscopic observations that allowed us to derive radial velocity measurements, together with the host-star parameters and properties. We also analyzed the light curve to derive the star?s rotation period and the phase function of the planet, including the secondary eclipse.  Results. We secured the planetary nature of Kepler-412b. We found the planet has a mass of 0.939 ± 0.085MJup and a radius of 1.325 ± 0.043RJup, which makes it a member of the bloated giant subgroup. It orbits its G3 V host star in 1.72 days. The system has an isochronal age of 5.1 Gyr, consistent with its moderate stellar activity as observed in the Kepler light curve and the rotation of the star of 17.2 ± 1.6 days. From the detected secondary we derived the day-side temperature as a function of the geometric albedo. We estimated that the geometrical albedo Ag should be between 0.094 ± 0.015 and 0.013+0.017-0.013 and the brightness of the day side 2380 ± 40 K. The measured night-side flux corresponds to a night-side brightness temperature of 2154 ± 83 K, much greater than what is expected for a planet with homogeneous heat redistribution. From the comparison to star and planet evolution models, we found that dissipation should operate in the deep interior of the planet. This modeling also shows that despite its inflated radius, the planet presents a noticeable amount of heavy elements, which accounts for a mass fraction of 0.11 ± 0.04.","palabras_clave":"planetary systems|binaries: spectroscopic|techniques: radial velocities|techniques: spectroscopic|techniques: photometric"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":17177,"idioma_id":4,"titulo":"A simple protocol for combinatorial cyclic depsipeptide libraries sequencing by matrix assisted laser desorption\/ionisation mass spectrometry","resumen":"    Short cyclic peptides have a great interest in therapeutic, diagnostic and affinity chromatography applications. The screening    of ?one-bead-one-peptide? combinatorial libraries combined with mass spectrometry (MS) is an excellent tool to find peptides    with affinity for any target protein. The fragmentation patterns of cyclic peptides are quite more complex than those of    their linear counterparts, and the elucidation of the resulting tandem mass spectra is rather more difficult. Here, we propose    a simple protocol for combinatorial cyclic libraries synthesis and ring opening before MS analysis. In this strategy, 4-    hydroxymethylbenzoic acid, which forms a benzyl ester with the first amino acid, was used as the linker. A glycolamidic ester    group was incorporated after the combinatorial positions by adding glycolic acid. The library synthesis protocol consisted in    the following: (i) incorporation of Fmoc-Asp[2-phenylisopropyl (OPp)]-OH to Ala-Gly-oxymethylbenzamide-ChemMatrix, (ii)    synthesis of the combinatorial library, (iii) assembly of a glycolic acid, (iv) couple of an Ala residue in the N-terminal, (v) removal    of OPp, (vi) peptide cyclisation through side chain Asp and N-Ala amino terminus and (vii) removal of side chain    protecting groups. In order to simultaneously open the ring and release each peptide, benzyl and glycolamidic esters were    cleaved with ammonia. Peptide sequences could be deduced from the tandem mass spectra of each single bead evaluated.    The strategy herein proposed is suitable for the preparation of one-bead-one-cyclic depsipeptide libraries that can be easily    open for its sequencing by matrix-assisted laser desorption\/ionisation MS. It employs techniques and reagents frequently    used in a broad range of laboratories without special expertise in organic synthesis. Copyright © 2014 European Peptide    Society and John Wiley &amp; Sons, Ltd.","palabras_clave":"GLYCOLIC ACID| 4-HYDROXYMETHYLBENZOIC ACID|2-PHENYLISOPROPYL|CHEMMATRIX RESIN|MALDITOF MSMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":17370,"idioma_id":4,"titulo":"Anomalies in vortex lattice dynamics driven by induced ac currents in superconducting films with magnetic arrays of two-fold symmetry","resumen":"We study the dynamics of the vortex lattice driven by ac induced currents in the critical state regime, for T > 0.70 TC. The samples are superconducting films grown on top of two-fold symmetry array of magnetic dots. In these heterostructures, the induced ac currents flow parallel to the short and to the long side of the pinning array in different areas of the samples simultaneously. This behavior produces remarkable effects in the vortex lattice dynamics. First of all, periodic features are observed in the ac susceptibility versus applied magnetic field measurements which are related to matching effects between the vortex lattices and the magnetic array. However, the vortex lattice reconfiguration observed in magnetotransport experiments is absent. Some of these features are revealed as maxima instead of being minima, indicating higher mobility at certain matching fields. Competing unstable vortex configurations could lead to increase vortex mobility precluding the reconfiguration transition. At high temperatures, where the matching effects show up, the magnetic permeability of the dots is the mechanism that governs the JC(T) behavior. Moreover, the temperature dependence of the pinning force FP(T) shows a temperature crossover related to an unexpected enhancement in vortex mobility. Vortex?vortex interaction and the interplay between trapped and interstitial vortices are a hint to explain these phenomena.","palabras_clave":"SUPERCONDUCTING FILMS|RECTANGULAR ARRAY PINNING|ANOMALIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":17558,"idioma_id":4,"titulo":"Colletotrichum siamense causing anthracnose in Bauhinia forficata subsp. pruinosa in Argentina","resumen":"Bauhinia forficata subsp. pruinosa is a common perennial tree species native to South America that belongs to the Fabaceae. In December 2010 and 2011, plants from a nursery located in the province of Buenos Aires, Argentina presented typical symptoms of anthracnose. We isolated from the lesions of diseased leaves a fungus that based on morphological as well as the ITS (KC132841) and &#946;-tubulin sequences (KJ829534) was identified as Colletotrichum siamense. After 12 days leaves inoculated with the fungal spore suspension developed lesions similar to those observed in natural infections. The fungus was then re-isolated fulfilling Koch?s Postulates. To our knowledge, this is the first report of Colletotrichum siamense causing anthracnose in Bauhinia forficata subsp. pruinosa in Argentina.","palabras_clave":"Bauhinia forficata|Colletotrichum siamense|Pezuña de vaca|tree natives"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":17629,"idioma_id":5,"titulo":"El cuerpo femenino: entre las demandas sociales y la racionalidad tecno-científica.","resumen":"El presente trabajo aborda la conflictiva intersección entre el desarrollo tecno-científico y el campo de la subjetividad. Para tal abordaje se tomará como escenario privilegiado el marco de las tecnologías de reproducción humana asistida (TRHA). Asimismo se analizará cómo una de las principales nociones teóricas de la modernidad, la idea de la racionalidad instrumental y sus principios, se encuentra más vigente y operante que nunca. Para pensar el alcance que la racionalidad tecno-científica tiene en el campo de lo humano, se tomaran los principales planteos que Hannah Arendt desarrolla en torno a las categorías de trabajo, labor, creación y producto. Por último reflexionaremos en torno al lugar de la mujer en este escenario inédito que son las tecnologías reproductivas en la historia de la humanidad; la tensión que se presenta entre el mandato social y el orden del deseo, la feminidad y la maternidad en el entramado subjetivo y en el orden deseante.","palabras_clave":"RACIONALIDAD INSTRUMENTAL |TECNOLOGÍAS DE REPRODUCCIÓN HUMANA ASISTIDA |REPROGENÉTICA |ÉTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":17716,"idioma_id":5,"titulo":"La igualdad ?des-enmarcada?: a veinte años de la reforma Constitucional argentina de 1994","resumen":"El presente trabajo se propone analizar los cambios en el marco de interpretación del texto constitucional a lo largo de sus veinte años de vigencia, con el fin de dar cuenta de los procesos de interpelación del principio de igualdad. Se analizan además las diferentes formulaciones del principio de igualdad utilizadas durante ese proceso.    Se suele utilizar el término constitucionalismo aspiracional  para referirse a la reforma de 1994, no obstante creemos que es más apropiado el término constitucionalismo interpelable. A diferencia del primero, que desde una perspectiva top-down pone el foco en el constituyente, el segundo nos permite dar cuenta de un proceso de ida y vuelta, en el cual las interpelaciones al texto constitucional -los procesos down-top- resultan esenciales para comprender el alcance efectivo de las reformas. Para comprender mejor esto retomamos el concepto de marco (framing) desarrollado por Fraser (2008) con el fin de dar cuenta de la dimensión político-interpretativa propia de todo proceso constitucional. La función de este dispositivo conceptual es poner sobre la mesa no tanto el sentido sustantivo del principio de igualdad, sino los marcos desde los cuales es interpretado y re interpretado. En esta línea, la tesis de este trabajo afirma que fueron las movilizaciones populares de fines de la década de los noventa y comienzos de la siguiente los que permitieron un ?re-enmarcamiento? del texto constitucional reformado, es decir, desde el marco neoliberal esencialmente restrictivo de derechos, hacia un marco democrático emancipatorio que ha permitido desplegar, asimismo, a través del activismo judicial  (DELAMATA 2013) y la jurisprudencia el potencial igualitario contenido en la reforma.  Ese potencial puede ser leído en forma transversal en casos sobre acceso a la vivienda para personas en situación de emergencia habitacional, casos traccionados desde la defensa pública de la Ciudad de Buenos Aires (CARDINAUX y otros 2013);  sobre vacantes para el nivel inicial en el ámbito de la Ciudad cuya insuficiencia afecta en especial a aquellos sectores de la población en situación de pobreza, caso motorizado por una organización no gubernamental (RONCONI 2013);  sobre acceso de mujeres para ejercer la profesión de conductoras de transportes públicos concesionados en un contexto de discriminación indirecta ya que hasta entonces solo los varones eran (y son) choferes, caso planteado por una mujer y una organización que trabaja con temas de género,  entre otros. Esta línea de casos advierte que las cláusulas de igualdad pueden ser utilizadas para intentar desarmar condiciones de exclusión  y no sólo simplemente para trabajar situaciones de discriminación puntual. Insistimos, ausente en sus primeros años una voluntad política rotunda que sostuviera los desafíos de la igualdad, por el contrario en un ambiente político contrario a los reclamos igualitarios, la reforma constitucional del 94 en materia de igualdad se inscribe en lo que se conoce como el constitucionalismo aspiracional o en términos emancipatorios, interpelable. Esas cláusulas de igualdad son normas, son exigibles; sin embargo, esperan el plumero que las desempolve y las hagan parte de una estrategia de exigibilidad más o menos amplia según el reclamo. Esa podría ser la trama del relato sobre la suerte de las cláusulas de la igualdad en la constitución reformada de 1994. Es un relato que reconoce velocidades diversas: paso a paso, a cuentagotas, dependiendo de la fuerza y habilidad de los actores que las movilicen y de la eficacia de la estrategia de exigibilidad desplegada. De este modo se puede dar cuenta de la gradualidad en la efectivización del potencial igualitario de la reforma. Ahora bien, una vez establecido el contexto dentro del cual se establecen las márgenes de la interpretación constitucional, es preciso analizar las herramientas jurídicas que habilitan o cierran el juego de las nuevas demandas. Por ello en la tercera sección analizamos las diversas fórmulas de igualdad que permiten activar, en función de la interpelación ciudadana, los contenidos dormidos (Gargarella) de la reforma, de menor a mayor, es decir desde la limitada fórmula de la igualdad formal hasta las versiones más complejas que combinan ya aspectos materiales con simbólicos.","palabras_clave":"Reforma Constitucional|Igualdad|Derechos Sociales|Grupos desaventajados"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":17813,"idioma_id":4,"titulo":"NOVEL METHOD FOR DETERMINATION OF ZINC TRACES IN BEVERAGES AND WATER SAMPLES BY SOLID SURFACE FLUORESCENCE USING A CONVENTIONAL QUARTZ CUVETTE","resumen":"A new method for zinc pre-concentration\/separation and determination by molecular fluorescence is proposed. The metal was complexed with o-phenanthroline and eosin at pH 7.5 in Tris; a piece of filter paper was used as a solid support and solid fluorescent emission measured using a conventional quartz cuvette. Under optimal conditions, the limits of detection and quantification were 0.36 x 10-3 and 1.29 x 10-3 µg L&#8722;1, respectively, and the linear range from 1.29 x 10-3 to 4.50 µg L&#8722;1. This method showed good sensitivity and selectivity, and it was applied to the determination of zinc in foods and tap water. The absence of filtration reduced the consumption of water and  electricity. Additionally, the use of common filter papers makes it a simpler and more rapid alternative to conventional methods, with sensitivity and accuracy similar to atomic spectroscopies using a typical laboratory instrument.","palabras_clave":"Zinc traces |o-Phenanthroline| Eosin Solid surface"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":17919,"idioma_id":5,"titulo":"El trabajo remunerado y no remunerado en Rosario. La desigual distribución de los tiempos entre varones y mujeres","resumen":"El presente trabajo estudia los patrones de uso del tiempo de la población de la ciudad de Rosario en base a la Encuesta de Uso del Tiempo y Voluntariado del año 2010, realizada utilizando la metodología del ?diario de actividades? del día anterior. Por un lado, se evidenció la existencia de una fuerte división sexual del trabajo en la que los varones dedican más tiempo al trabajo realizado para el mercado que las mujeres, y en la que las mujeres destinan casi tres veces más tiempo que los varones al trabajo no remunerado (doméstico y de cuidados).  En segundo lugar se comprobó la existencia de una doble jornada femenina a partir del hecho de que las mujeres trabajan (remunerada y no remuneradamente) una mayor cantidad de horas que los varones, y se verificó que las mujeres trabajan más horas pero ganan menos, principalmente dado que su mayor carga de trabajo no recibe ninguna remuneración. Por último, a partir del análisis en función del nivel de ingresos se aprecia una desigualdad  adicional intra-mujeres, siendo que aquellas que viven en hogares de menores ingresos dedican una mayor cantidad de tiempo al trabajo no remunerado que aquellas de hogares de mayores ingresos.","palabras_clave":"TRABAJO NO REMUNERADO|USOS DEL TIEMPO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":17952,"idioma_id":4,"titulo":"GH, IGF-I and GH receptors mRNA expression in response to growth impairment following a food deprivation period in individually housed cichlid fish Cichlasoma dimerus","resumen":"Cichlasoma dimerus is a social cichlid fish capable of growing at high rates under laboratory conditions, but knowledge on somatic growth regulation is still unclear. Growth hormone (GH)\/insulin-like growth factor I (IGF-I) axis is the key regulator of somatic growth in vertebrates. Two types of growth hormone receptors have been described in teleost fish, named GH receptor type 1 (GHR1) and type 2 (GHR2). In addition, isoforms of these receptors lacking part of the intracellular region have been described. The aim of this study was to evaluate the somatic growth, liver histology and changes in the GH\/IGF-I axis after 4 weeks of food deprivation in C. dimerus. Four-week fasted fish showed reductions in specific growth rates in body weight (p < 0.001) and standard length (p < 0.001). Additionally, the hepatosomatic index (p < 0.001) and hepatocyte area (p < 0.001) decreased in fasted fish, while no changes in glucose levels were detected in plasma. The starvation protocol failed to induce changes in GH mRNA levels in the pituitary and IGF-I mRNA levels in liver. In contrast, IGF-I mRNA levels in muscle decreased in fasted fish (p = 0.002). On the other hand, GHR2 (detected with primer sets designed over the extracellular and intracellular region) was upregulated by starvation both in liver and muscle (p < 0.05), while GHR1 remained unchanged. These results show that a fasting period reduced somatic growth both in length and body weight concomitantly with alterations on liver and muscle GHR2 and muscle IGF-I mRNA expression.","palabras_clave":"GH|IGF-I|GHR1-GHR2|fasting"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":18048,"idioma_id":4,"titulo":"Hematologic variables determined in animals porcine production of establishments in Litoral regional Argentina","resumen":"    HEMATOLOGIC VARIABLES DETERMINED IN ANIMALS PORCINE PRODUCTION OF ESTABLISHMENTS IN LITORAL REGIONAL ARGENTINA    In this publication, were determined hematologic variables two breed animals porcine production: first (CH) and multigiven birth sows (G). Blood samples were taken from eyes veins of 35 CH and 38 G females butcher´s shops one  Entre Ríos and two center region Santa Fe, in winter 2013.         The parameters decided: Hto, GR, Hb, VCM, HCM, CHCM;  GB; y la fórmula leucocitaria: N, E, B, L y M; manual methods used: Microtechnology with the capillaries for Hto; Neubauer´s chamber for count of GB - GR and method cianmetahemoglobin colorimetric for Hb. May Grünwald-Giemsa´s tint was applied for the formulum lecociumThe indexes hematimétricos were calculated.         Was applied the method ANOVA, in analysis of the variance.         The mean values and standard deviations in CH and G were: GB(\/mm3) 13.953,4 ± 4.877,5; 10.167,6 ± 3.728,17, N(%) 29,31 ± 6,36; 34,26 ± 7,29, E(%) 2,46 ± 1,04; 2,37 ± 1,26, B(%)        0,37 ± 0,49; 0,13 ± 0,33, L(%) 65,89 ± 7,47; 61,68 ± 7,55, M(%) 1,94 ± 0,83; 1,71 ± 0,73, GR(\/mm3) 6.279.496 ± 620.780; 5.747.166 ± 669.416, Hb(g\/dL) 11,94 ± 0,56; 11,30 ± 1,39, Hto(%) 32,43 ± 5,00; 30,68 ± 5,06, VCM(fL) 51,42 ± 3,64; 53,50 ± 4,75, HCM(pg) 19,17 ± 1,40; 19,70 ± 1,2, CHCM(g\/dL) 37,53 ± 4,83; 37,18 ± 3,06, respectively.         Could be observed statistical differences (p           ","palabras_clave":"HEMATOLOGIC|PORCINE|PRODUCTION|ESTABLISHMENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":18049,"idioma_id":4,"titulo":"Study of mineral profile during the transition  in  dairy cattle of Las Colonias department - Santa Fe","resumen":"STUDY OF MINERAL PROFILE DURING THE TRANSITION  IN  DAIRY CATTLE OF LAS COLONIAS DEPARTMENT - SANTA FE   In different physiological states of dairy cows, important minerals seeks modifications of fetal development, birth, breeding, and the initiation and maintenance of milk production are presented. The highest incidence of disease production occurs in the transition period or peripartum. The aim of our study was to characterize the blood levels of macro and micro minerals in 58 Holstein Friesian dairy cows during the transition period in the Las Colonias Department during the fall and spring 2013-2014. The blood was drawn from jugular vein with 20 mL syringes, the serum was separated from these samples Macrominerals: calcium (Ca), magnesium (Mg), sodium (Na) and potassium (K); and trace elements: iron (Fe), zinc (Zn) and copper (Cu) and phosphorus (P) were determined by atomic absorption spectroscopy. The equipment used is a Perkin Elmer model 3110 ANOVA statistical method was used to treat the data. The mean values &#8203;&#8203;of serum mineral profile in dairy cattle were within the range reported by the national and international literature as a reference. There is significant difference between the mean values &#8203;&#8203;of Cu in autumn and spring because the availability of the mineral in the food varies by season. The low values &#8203;&#8203;of Fe and Zn in both seasons for lactogenesis. Normal value of Ca was noted in the transition due to the smooth operation of homeostatic mechanism. The values &#8203;&#8203;of Mg in autumn and spring are in lower limit of  reference range in precalving, this is due more to a failure in absorption of mineral rumen, associated with diminished by high stocking intake or depression appetite for pregnancy.Both input values &#8203;&#8203;as related to the homeostatic mechanism regulating levels of blood macrominerals were adequate and allowed optimal nutritional metabolic balance, as such, except in isolated cases, no production diseases were observed.   ","palabras_clave":"MINERAL|TRANSITION|DAIRY|CATTLE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":18063,"idioma_id":5,"titulo":"Estudio de competitividad de las pymes exportadoras de la región de Villa María (Argentina)","resumen":"PRESENTA UN ESTUDIO COMPARATIVO DE LAS CARACTERÍSTICAS DE LAS PYMES DE LA REGIÓN DE VILLA MARÍA QUE LAS HACEN COMPETITIVAS CON SUS PARES DE LATINOAMERICANAS Y ESPAÑOLAS. A PARTIR DE UN ESTUDIO APLICADO EN LOS PAÍSES LATINOAMERICANOS POR MEDIO DE UNA METODOLOGÍA HOMOGÉNEA, ESTABLECIDA POR LA FUNDACIÓN PARA EL DESARROLLO ESTRATÉGICO DE LAS PYMES.","palabras_clave":"COMPETITIVIDAD|PYMES|EXPORTADORAS|EFICIENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":18567,"idioma_id":4,"titulo":"Effect of Sintering Time of CaTiO3-CaCO3 in Osteoblastic Response of KUSA\/A1 Cells","resumen":"In recent years, calcium titanate (CaTiO3) andcarbon-containing materials have gained much attention in anumber of biomedical material researches. To maximize theadvantages of both materials, we developed a novel alkoxidemethod to get ??calcium titanate with calcium carbonate??(CaTiO3?CaCO3). Thus, our previous result indicated thatcalcium carbonate could play a key role in the cell response ofCaTiO3 material. In the present study we evaluated the effectof sintering time of CaTiO3-CaCO3in osteoblastic response ofKUSA\/A1 cells. We examined the material characterization aswell as cellular proliferation and mineralization of KUSA\/A1cells cultured with the materials. The results showed that CaTiO3?CaCO3material sintered during 30 min, has better influenceon the bone marrow stromal cells for their proliferationand mineralization compared to CaTiO3-CaCO3 sintered at 2and 10 h. These results suggest that sintering time could bedirectly related to the amount of carbon within CaCO3 beingcrucial in cell response. In conclusion, our preliminary findingsindicate that CaTiO3?CaCO3 could play a more dominantand favorable effect on cell response when sintered for 30minutes.","palabras_clave":"Carbonate |calcium titanate|particles|cell culture osteoblasts"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":18675,"idioma_id":5,"titulo":"Formadores de Profesores de Psicología, Prácticas de Enseñanza y Construcción de Saberes: Cruzando Fronteras entre Escenarios y Perspectivas Diferentes","resumen":"ResumenEl trabajo analiza ideas explícitas e  implícitas que construyen Formadores\/ Tutores de Profesores de Psicología en Formación en Universidad de Buenos  Aires. Unidad de Análisis: Modelos Mentales Situacionales de Intervención. Objetivo:  identificar fortalezas y nudos críticos en la elaboración  reflexiva de la Praxis Formativa del Profesorado en Educación Media y Superior.  Estudio descriptivo y exploratorio con análisis cualitativos y cuantitativos. Comunidades de práctica y categorías de análisis del Enfoque  Socio-Cultural (Vygotsky) y Teoría de la Actividad (Engeström) son  re-contextualizadas, entramadas con&nbsp;  investigación en Prácticas y Residencias (Terigi, Edelstein). Se administró Cuestionario sobre Situaciones Problema del Formador de Profesores de  Psicología a 18 Tutores y 21 Co-tutores de Didáctica Especial  y Prácticas de Enseñanza en Psicología y se aplicó Matriz Multidimensional de Análisis. Fortalezas: complejidad, historización,  inter-agencialidad, pertinencia\/especificidad, dilemas éticos. Nudos críticos:  escasa investigación-intervención, destinatario unidireccional y  sobre-implicación en Co-tutores. Construcción estratégica de tramas  inter-agenciales y entrelazamientos inter-institucionales para &nbsp;aprendizaje  expansivo profesional. ","palabras_clave":"SISTEMAS DE ACTIVIDAD,   |MODELOS MENTALES,,   |ENSEÑANZA|COMUNIDAD DE PRÁCTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":18819,"idioma_id":4,"titulo":"Regulation of NF-kB signalling cascade by immunophilins","resumen":"The fine regulation of signalling cascades is a key event required to maintain the appropriate functional properties of a cell when a given stimulus triggers specific biological responses. In this sense, cumulative experimental evidence during the last years has shown that high molecular weight immunophilins possess a fundamental importance in the regulation of many of these processes. It was first discovered that TPR-domain immunophilins such as FKBP51 and FKBP52 play a cardinal role, usually in an antagonistic fashion, in the regulation of several members of the steroid receptor family via its interaction with the heat-shock protein of 90-kDa, Hsp90. These Hsp90-associated cochaperones form a functional unit with the molecular chaperone influencing ligand binding capacity, receptor trafficking, and hormone-dependent transcriptional activity. Recently, it was demonstrated that the same immunophilins are also able to regulate the NF-kB signalling cascade in an Hsp90 independent manner. In this article we analize these properties and discuss the relevance of this novel regulatory pathway in the context of the pleiotropic actions managed by NF-kB in several cell types and tissues.","palabras_clave":"FKBP51|FKBP52|HSP90|FK506|p65|p50|NFkB"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":18827,"idioma_id":4,"titulo":"Experimental Analysis of the Modified Fingerprint Technique in Outdoor Areas","resumen":"GPS is the most popular positioning system; however, it does not offer good performance indoors or in densely urbanized areas. Wi-Fi positioning systems offer excellent services for enclosed spaces using the existing network infrastructure to calculate the position of the mobile device. The most commonly used parameter is signal strength. This paper discusses outdoor accuracy of Wi-Fi positioning systems based on the Fingerprint technique with some variations aimed at improving the accuracy of the technique and minimizing calculation times.","palabras_clave":"OUTDOOR|POSITIONING|FINGERPRINT|RSSI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":18858,"idioma_id":4,"titulo":"Discrete time schemes for optimal control problems with monotone controls","resumen":"In this article, we consider the Hamilton-Jacobi-Bellman equation associated with the optimization problem with monotone controls. The problem deals with the infinite horizon case and costs with update coefficients. We study the numerical solution through the discretization in time by finite differences. Without the classical semiconcavity-like assumptions, we prove that the convergence in this problem is of order gamma in contrast with the order gamma\/2 valid for general control problems. This difference arises from the simple and precise way the monotone controls can be approximated. We illustrate the result with a simple example.","palabras_clave":"MONOTONE OPTIMAL CONTROL PROBLEMS|HJB EQUATIONS|NUMERICAL SOLUTIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":19670,"idioma_id":4,"titulo":"BUILDING'S INFLUENCE OVER THE URBAN HEAT ISLAND","resumen":"It is determined the buildings? effect on the intensity of the urban heat island (UHI) in winter and summer, correlating it with the main urban indicators. The images of the satellite Landsat 5 TM+ are used to determine air temperature. The thermal data obtained from these images was referred with in situ thermal data of the urban area obtained with a fixed meteorological station. The thermo-referred values obtained were extrapolated to shift the satellite time record from 16:00hs to 21:00hs (Argentine local time), whose center-periphery temperature difference is the most representative in the UHI. There is demonstrated a strong correlation between the urban occupation and the intensity of the heat island. The maximum heat island intensity resulted in 5.0 ° C for summer and 4.5 ºC for winter.","palabras_clave":"URBAN TEMPERATURE|URBAN INDICATORS|REMOTE SENSORS|URBAN CLIMATE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":19741,"idioma_id":4,"titulo":"Treatment in vitro with PPAR&#945; an d P PA R&#947; ligands drives M1-to-M2 polarization of macrophages fromT. cr uz i-infected mice","resumen":"Trypanosoma cruzi, the etiological agent of Chagas´ disease, induces a persistent inflammatory response. Macrophages are a first line cell phenotype involved in the clearance of infection. Upon parasite uptake, these cells increase inflammatory mediators like NO, TNF-&#945;, IL-1&#946; and IL-6, leading to parasite killing. Although desired, inflammatory response perpetuation and exacerbation may lead to tissue damage. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent nuclear transcription factors that, besides regulating lipid and carbohydrate metabolism, have a significant anti-inflammatory effect. This is mediated through the interaction of the receptors with their ligands. PPAR&#947;, one of the PPAR isoforms, has been implicated in macrophage polarization from M1, the classically activated phenotype, to M2, the alternatively activated phenotype, in different models of metabolic disorders and infection. In this study, we show for the first time that, besides PPAR&#947;, PPAR&#945; is also involved in the in vitro polarization of macrophages isolated from T. cruzi-infected mice. Polarization was evidenced by a decrease in the expression of NOS2 and proinflammatory cytokines and the increase in M2 markers like Arginase I, Ym1, mannose receptor and TGF-&#946;. Besides, macrophage phagocytic activity was significantly enhanced, leading to increased parasite load. We suggest that modulation of the inflammatory response by both PPARs might be due, at least in part, to a change in the profile of inflammatory macrophages. The potential use of PPAR agonists as modulators of overt inflammatory response during the course of Chagas´ disease deserves further investigation.","palabras_clave":"INFLAMMATORY MEDIATORS|MACROPHAGE POLARIZACIÓN |PPAR|TRIPANOSOMA CRUZI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":20066,"idioma_id":4,"titulo":"Spatial variation in tree demography associated to domestic herbivores   and topography: insights from a seeding and planting experiment.","resumen":"Tropical and subtropical high mountains forests are mainly situated within ravines. Two alternative and  often confronted explanations have been proposed for this pattern: that abiotic environmental conditions  are favourable for tree establishment only within ravines, or that ravines are less affected by grazing and  fires which negatively affect establishment in other sites. Here we propose a mixed explanation and  hypothesize that abiotic environmental conditions associated to spatial variation are important during  early seedling establishment and that grazing is the main determinant during later stages through its  negative effect on survival and growth of larger saplings. We sowed 302,400 seeds and planted 360 saplings  of the dominant tree species from the upper Córdoba Mountain range (Central Argentina) with and  without grazing in three contrasting sites: a ravine, a valley and a ridge. We monitored seeding plots  5 years until the seedlings reached the height of the planted saplings and we monitored the planted saplings  for 12 years. We integrated life stages using matrix multiplications, which resulted in data simulating  17 years of the trees? early development. Our results showed that seedling establishment was lower  in the ravine and ridge sites and higher in the valley site with negative differences due to grazing only in  the valley. Planted sapling survival increased but growth decreased from ravine to valley and ridge sites  in the absence of large herbivores, while both survival and growth were substantially lower in the presence  of large herbivores. Matrix multiplications indicated that differences between sites were 5.0 times  more important than grazing when integrating up to year 5, but grazing by large herbivores was 5.4 times  more important than differences between sites when assessed across the whole 17 year period. We conclude  that there could be a strong influence of grazing in restricting high montane forests to sites like  ravines where large herbivores are less frequent and show how the relative importance of site characteristics  and grazing changes as a result of the length and the differing life stages which are monitored.","palabras_clave":"Browsing|Livestock|Matrix modelling|Polylepis australis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":20256,"idioma_id":4,"titulo":"6-Methoxyflavonoids and Other Constituents from Microliabum polymnioides (Asteraceae)","resumen":"The flower heads of Microliabum polymnioides afforded scopoletin, 5,4´-dihydroxy-3,6,7-trimethoxyflavone, 3,5,4´-trihydroxy-6,7-dimethoxyflavone and 3,5,7,4´-tetrahydroxy-6-methoxyflavone. The leaves ontained hexadecanoic acid, phytol and docosane.  This is the first report on the presence of 6-methoxyflavonoids in Microliabum genus.","palabras_clave":"ASTERACEAE|FLAVONOIDS|MICROLIABUM|PHYTOCHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":20365,"idioma_id":4,"titulo":"Methodology developed for the simultaneous measurement of bone formation and bone resorption in rats based on the pharmacokinetics of fluoride","resumen":"This paper describes a novel methodology for the simultaneous estimation of bone formation (BF) and resorption (BR) in rats using fluoride as a nonradioactive bone seeker ion. Fluoride pharmacokinetic has been extensively studied in rats; its constants have all been characterized. This knowledge was the cornerstone for the underlying mathematical model we used to measure bone fluoride uptake and elimination rate after a dose of fluoride. Bone resorption and formation were estimated by bone fluoride uptake and elimination rate, respectively. ROC analysis showed that sensitivity, specificity and area under the ROC curve were not different from deoxypiridinoline and bone alkaline phosphatase, well known bone markers. Sprague Dawley rats with modified bone remodelling (ovariectomy, hyper and hypocalcic diet, antiresorptive treatment) were used to validate the values obtained with this methodology. The results of BF and BR obtained with this technique were as expected for each biological model. Although the method should be performed under general anaesthesia, it has several advantages: simultaneous measurement of BR and BF, low cost and the use of compounds with no expiration date.","palabras_clave":"BONE FORMATION|BONE RESORPTION|FLUORIDE|RAT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":20368,"idioma_id":5,"titulo":"Patrones de comportamiento de dos especies de flamenco (Phoenicoparrus andinus y Phoenicopterus chilensis) y su relación con las condiciones meteorológicas de la Laguna Melincué, Argentina, durante la temporada invernal","resumen":"Los flamencos son aves gregarias que habitan ambientes de agua salina. Durante el invierno dos especies de flamencos (Flamenco Andino: Phoenicoparrus andinus y Flamenco Austral: Phoenicopterus chilensis) viven en las lagunas del sur de Santa Fe, Argentina. Este trabajo tuvo por objetivos determinar los patrones de comportamiento de estas dos especies que conviven durante la estación invernal en Laguna Melincué, analizar las maneras en que éstos se comportan, y evaluar la influencia de determinadas variables climáticas sobre tales comportamientos. Durante el mes de julio de 2011 seleccionamos individuos adultos de ambas especies de flamencos. Para cada individuo se registró el comportamiento que realizaba durante un periodo de tres minutos y simultáneamente se registraron cinco variables meteorológicas (temperatura, sensación térmica, presión atmosférica, humedad relativa, velocidad promedio del viento). Las principales actividades registradas para ambas especies fueron el descanso, el aseo y la alimentación. Se detectaron diferencias significativas entre especies en sus patrones de comportamiento. El Flamenco Andino dedicó mayor tiempo a actividades de traslado y alerta, mientras que el Flamenco Austral pasó más tiempo en descanso. Los individuos de ambas especies dedicaron mayor tiempo a la alimentación durante períodos de elevada presión atmosférica, y mayor tiempo al descanso cuando se registraron fuertes vientos. Los Flamencos Andinos fueron más activos, siendo menos afectados por el viento. Este trabajo señala la necesidad de continuar con estudios ecoetológicos a largo plazo sobre estas especies. Este conocimiento sobre la biología de los flamencos, podría ser utilizado en el diseño e implementación de planes de acción para la conservación de estas especies y sus humedales asociados.","palabras_clave":"COMPORTAMIENTO|FLAMENCOS|PAMPAS|MELINCUE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":20852,"idioma_id":4,"titulo":"Effect of Quenched Disorder in the Entropy-Jump at the First-Order Vortex Phase Transition of Bi2Sr2CaCu2O8+&#948;","resumen":"We study the effect of quenched disorder in the thermodynamic magnitudes entailed in the first-order vortex phase transition of the extremely layered BiBi2Sr2CaCu2O8+&#948; compound. We track the temperature-evolution of the enthalpy and the entropy jump at the vortex solidification transition by means of AC local magnetic measurements. Quenched disorder is introduced to the pristine samples by means of heavy-ion irradiation with Pb and Xe producing a random columnar-track pins distribution with different densities (matching field B&#934;). In contrast with previous magneto-optical reports, we find that the first-order phase transition persists for samples with B&#934; up to 100 Gauss. For very low densities of quenched disorder (pristine samples), the evolution of the thermodynamic properties can be satisfactorily explained considering a negligible effect of pinning and only electromagnetic coupling between pancake vortices lying in adjacent CuO planes. This description is not satisfactory on increasing magnitude of quenched disorder.","palabras_clave":"local magnetic properties|first-order phase transitions|high-temperature superconductivity|columnar defects disorder"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":21347,"idioma_id":4,"titulo":"Geographic variation in the advertisement call of Hypsiboas cordobae (Anura, Hylidae)","resumen":"Geographic variation in the advertisement call of anuran is commonly observed among conspecific populations. We analyzed the geographic variation of advertisement calls in six populations of the Argentinean treefrog species Hypsiboas cordobae throughout its geographic distribution. The advertisement calls of this species consisted of three, four or five tonal notes. Spectral call variables showed significant differences among populations, as in the first and second inter-note intervals. Discriminant function analysis demonstrated significant multivariate differences among populations. All spectral variables exhibited clinal variation, with frequencies increasing significantly from north to south. These same variables were negatively correlated with the altitudes of the six populations. Mantel tests showed no significant correlation between geographic distances and bioacoustic distances or between altitudinal distances and bioacoustic distances, attributable to that call variations are due to different levels of latitudinal and altitudinal populations studied, and not to the distances between pairs of localities. Altitudinal variation in spectral properties may be attributable to an inverse relation with body size, which varies clinally along the same geographical axis.","palabras_clave":"HYPSIBOAS CORDOBAE|GEOGRAPHIC VARIATION|ADVERTISEMENT CALL|ALTITUDE|LATITUDE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":21774,"idioma_id":4,"titulo":"Prestorage Treatment of 'Hayward' Kiwifruit with 1-MCP: the Effect of Harvest Maturity","resumen":"The objective of the present work was to study the effect of the harvestmaturity on the response to the application of 1-methylcyclopropene (1-MCP) inprestorage of kiwifruit ?Hayward? produced in the Mar del Plata area (38°0?S,57°30?W), Buenos Aires, Argentina. The kiwifruits were harvested at 142, 177 and190 days after bloom (MS1, MS2 and MS3, respectively); half of the fruits weretreated with 1 &#956;l L-1 1-MCP for 24 h and the others were untreated (controls). Fruitswere stored for six months at 0°C and 95% RH. Firmness (N), color (CIELab*),soluble solids content (SSC) and titratable acidity (TA) were analyzed at the end ofthe cold storage (ECS) and shelf-life (seven days at 20°C). Maturity stage at harvestaffected the color, SSC and TA at ECS and shelf-life without significant effects of 1-MCP treatment. The 1-MCP application increased fruit firmness in both at ECS andshelf-life, especially at MS1. The MS1 presented the lowest values of SSC and TA,being the SSC content less than the adequate to satisfy the consumers. The fruitstreated with 1-MCP matured normally, without physiological disorders, or externalsymptoms of toxicity. In conclusion, the 1-MCP treatment delayed softening ofkiwifruit in the three maturity stages. This effect was greater in MS1, but thismaturity stage showed a sub-optimal SSC values for consumption.","palabras_clave":"Storage|Shelf-life|Fruit firmness|Fruit quality"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":23298,"idioma_id":4,"titulo":"INTESTINAL UPTAKE AND TOXICITY EVALUATION OF ACETAZOLAMIDE AND ITS MULTICOMPONENT COMPLEXES WITH HIDROXYPROPYL-B-CYCLODEXTRIN IN RATS","resumen":"Large oral doses of ACZ lower the intraocular pressure (IOP), but usually lead to a multitude of systemic side effects, including gastrointestinal upset. The present study was undertaken to evaluate the effect of  ACZ on the histological structure of rat duodenal mucosa and to assess a possible protective role of the complex formation of ACZ with HP-b-CD, either separately or in combination with a third compound, on  the gut epithelial layer by histological and ultrastructural examinations of sections of rat duodenum exposed to ACZ or its formulations. In addition, the transport process of ACZ and its binary or ternary complexes across the duodenal mucosa by means of the single-pass intestinal perfusion (SPIP) method in rats was evaluated. Evidence was found that ACZ alters intestinal permeability and induces damage to the  rat small intestine. In contrast, ACZ-induced intestinal injury may be abrogated by ACZ complexation. In addition, the complexation of ACZ with HP-b-CD, alone or in combination with a third compound, facilitated significant levels of ACZ uptake across the rat duodenal segment. Ternary complexes of ACZ with HP-b-CD in combination with TEA (triethanolamine) or calcium ions were found to provide an excellent approach that enabled an increased apparent permeability of ACZ across the duodenal epithelium, with a concomitant ability to preserve the integrity of the gut epithelium from ACZ-induced injury. These results could be useful for the design and development of novel ACZ formulations that can reduce GI toxicity, while still maintaining their essential therapeutic efficacies.","palabras_clave":"INTESTINAL UPTAKE|MULTICOMPONENT COMPLEXES|ACETAZOLAMIDE|CYCLODEXTRINES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":23960,"idioma_id":5,"titulo":"Propiedades psicométricas del Test revisado de Necesidad de cierre cognitivo (TR-NCC) en una muestra de estudiantes de la Universidad de Buenos Aires","resumen":"JAUME, LUIS; CERVONE, NÉLIDA; BIGLIERI, JORGE; QUATTROCCHI, PAULA. Propiedades psicométricas del Testrevisado de Necesidad de cierre cognitivo (TR-NCC) en una muestra de estudiantes de la Universidad de BuenosAires.. Investigaciones en Psicología.: Facultad de Psicología. 2014 vol.21 n°3. p55 - 60. issn 0329-5893.","palabras_clave":"NCC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":24136,"idioma_id":5,"titulo":"PROPAGACIÓN CLONAL DE Peltophorum dubium (Caña fistola), Myrocarpus frondosus (Incienso), y Cordia trichotoma (Peteribi) PARA SU CONSERVACION Y DOMESTICACION","resumen":"Resumen:En el presente trabajo se describe la implementación de tecnologías de producción de minicepas y miniestacas, accesibles a pequeños y medianos viveristas, para las siguientes  especies leñosas multipropósito: Peltophorum dubium (Caña fistola), Myrocarpus frondosus (Incienso) y Cordia trichotoma (Peteribi). Se evaluò la tasa de rebrote de minicepas, y el posterior enraizamiento de las miniestacas obtenidas para las mencionadas especies. Las minicepas fueron criadas en macetas de 3 litros en invernaculo, y en el enraizamiento de las miniestacas se realizaron aplicaciones de AIB (Acido Indol Butirico) en la base de las miniestacas para favorecer  el enraizamiento. Los valores promedios de producción de minicuttings fue de un rango de 770 a 900 estacas\/m2\/año, considerando solo tres colectas al año.  La capacidad de enraizamiento fue del 70% en todas las especies estudiadas. En Caña fístola e Incienso se obtuvieron miniestacas enraizadas sin la utilización de reguladores de crecimiento (AIB).   El presente estudio demostró que la técnica de minicepas y miniestacas tiene un gran potencial para la producción masiva de familias de Peltophorum dubium (Caña fistola), Myrocarpus frondosus (Incienso) y Cordia trichotoma (Peteribi), generando brotes de vigorosos, con diámetros mayores a 3 mm, en minicepas, para la producción de miniestacas con alta capacidad de sobrevivencia y enraizamiento.","palabras_clave":"MINCEPAS|MINESTACAS|ENRAIZAMIENTO|PLANTA MADRE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":24146,"idioma_id":5,"titulo":"Evaluación de la Aguas Termales en el área de Santa Teresita, Provincia de La Rioja, Argentina","resumen":"EVALUACIÓN DE LA AGUAS TERMALES EN EL ÁREA DE SANTA TERESITA, PROVINCIA DE LA RIOJA, ARGENTINA. Desde mediados del siglo XX se conoce la existencia de recursos hidrotermales en el extremo norte de la sierra de velasco, ubicados en la localidad de Santa Teresita y parajes aledaños como los médanos, el palmar, la chilca y suri yaco. Las primeras explotaciones de aguas subterráneas en la región, las realizó el Ejército Argentino, entre los años 1940 y 1950, en la localidad de Los Médanos, próximo a las riberas del río Salado o Abaucán, con el fin de fomentar el desarrollo de colonias agrícolas en la región. Las manifestaciones estudiadas se encuentran el extremo sur de la Cuenca Hidrogeológica del Salar de Pipanaco, dentro de la Provincia Hidrogeológica de Valles Intermontanos de las Sierras Pampeanas (Sosic 1973). Las aguas subterráneas en este sector, se encuentran fundamentalmente en depósitos cuaternarios y en menor proporción, en sedimentitas terciarias. Para este trabajo se analizaron 10 muestras de pozos termales y 2 de vertientes, y se evaluaron parámetros físicos y químicos, tales como la temperatura de emergencia de la fuente, pH, caudal, conductividad, dureza, entre otros, y las concentraciones iónicas de cationes y aniones mayoritarios, que permitieron realizar su caracterización química y la aplicación de geotermómetros catiónicos.","palabras_clave":"Hidrotermalismo|Geotermometros|Santa Teresita|La Rioja"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":24289,"idioma_id":5,"titulo":"GENERACION DEL AÑO METEOROLOGICO TIPICO PARA LA CIUDAD DE SANTA FE EN LA REGIÓN LITORAL ARGENTINA","resumen":"Este trabajo está dedicado a la definición del año meteorológico típico (TMY, del inglés Typical Meteorological Year) en la ciudad de Santa Fe, ubicada en la región Litoral de la República Argentina. La definición del año típico es fundamental para  la elaboración del archivo climático utilizado por los códigos de Simulación Energética de Edificios (BES, del inglés Building Energy Simulation). Se partió de datos proporcionados por el Servicio Meteorológico Nacional (SMN) de Argentina sobre diversas variables meteorológicas (temperatura de bulbo seco, temperatura de punto de rocío, humedad, etc.) registradas en intervalos horarios a lo largo de 14 años (2000-2013) en el Aeropuerto de Sauce Viejo (latitud 31.70°S, longitud 60.82°O, elevación 17 msnm). En base a criterios estadísticos, por cada mes del año, uno de todos los meses de muestra se cataloga como Mes Meteorológico Típico (TMM, del inglés Typical Meteorological Month). La concatenación de los doce TMMs define el TMY.","palabras_clave":"AÑO METEOROLÓGICO TÍPICO|CIUDAD DE SANTA FE|REGIÓN LITORAL ARGENTINA|SIMULACIÓN ENERGÉTICA DE EDIFICIOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":24351,"idioma_id":4,"titulo":"Unfalsified Control Based on the H-infinity Controller Parameterisation","resumen":"This paper presents an implementation of the unfalsified control (UC) method using the Riccati-based parameterisation of H-infinity controllers. The method provides an infinite controller set to (un)falsify the real-time data streams seeking for the best performance. Different sets may be designed to increase the degrees of freedom of the set of controller candidates to perform UC. In general, a set of m central controllers could be designed, each one seeking different objectives and all with their own parameterisation as a function of a stable and bounded transfer matrix. For example, one controller parameterisation could be designed to solve the robust stability of a model set which covers the physical system, therefore guaranteeing feasibility.  The implementation requires the online optimisation of either quadratic fractional or quadratic problems, depending on the selection of the cost function. A multi-input, multi-output (MIMO) time-varying model of a permanent magnet synchronous generator illustrates the use of this technique.","palabras_clave":"unfalsified control|H-infinity controller parameterization|linear fractional transformation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":24558,"idioma_id":5,"titulo":":   Situación laboral de los Jóvenes en el Gran Resistencia y Corrientes, Argentina, en el período 2010-2013","resumen":"En este artículo se presenta un estudio descriptivo del comportamiento del mercadolaboral de los jóvenes en los aglomerados urbanos Gran Resistencia y Corrientesdurante el período 2010 ? 2013. Se basa en el análisis de algunas de lasprincipales variables relacionadas con la problemática socioeducativa y laboral delos jóvenes, para lo cual se ha tomado como fuente de datos secundarios la Encuesta Permanente de Hogares del INDEC correspondientes a los 4° trimestres de los años mencionados.","palabras_clave":"JOVENES|MERCADO DE TRABAJO|GRAN RESISTENCIA|CORRIENTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":24646,"idioma_id":5,"titulo":"DIAGNOSTICO MOLECULAR DE TRICHINELLA SPIRALIS EN MUESTRAS DE SUEROS PORCINOS","resumen":"El objetivo de este proyecto es generar una herramienta preventiva dediagnóstico sensible y específica para una de las enfermedades zoonóticas másimportantes de nuestro país, la triquinosis, mediante el uso de técnicas deavanzada en biología molecular y así poder evitar el consumo de carnesinfectadas con este parásito y proponer a futuro un programa epidemiológico deerradicación en piaras. Para ello se cuenta con muestras de músculos ychacinados de cerdo y suidos silvestres y se contará con muestras de sangre decerdos inoculados con larvas new born de T. spiralis. Por otro lado, se pretende realizar estametodología como diagnóstico preventivo de esta enfermedad zoonótica a partirde muestras de sangre de pacientes con sintomatología típica remitidas en loscentros hospitalarios y de zoonosis de la Provincia de Buenos Aires (ANLISMalbrán y Zoonosis Rurales Azul). ","palabras_clave":"DIAGNOSTICO|PCR EN TIEMPO REAL|TRICHINELLA SPIRALIS |CERDOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25190,"idioma_id":4,"titulo":"2-Cyanobenzoic acids: Tautomeric equilibria study","resumen":"Evidence of ring-chain tautomerism in the gas phase from mass spectrometry and in solution determined by means of 1H NMR and 13C NMR is reported for 2-cyanobenzoic acids. The analysis of the corresponding spectra has allowed specific assignment of fragment ions to tautomers. The predictive value of this methodology is supported by the influence of the substitution pattern of these compounds on this equilibrium.","palabras_clave":"2-Cyanobenzoic acids|Tautomerism|Mass spectrometry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25220,"idioma_id":5,"titulo":"Estrategias argumentativas del discurso político Sordo en la Lengua de Señas Argentina","resumen":"El Discurso Político Sordo -DPS en adelante- en Lengua de Señas Argentina nos ha permitido en estos últimos años hacer varios análisis no solo gramaticales sino también discursivos y, aún más, sociopolíticos e ideológicos. Llamamos discurso político a la producción discursiva desde estructuras institucionales, tales como el Estado, ONGs, partidos políticos, asociaciones, etc. Estos trabajos ya realizados demuestran que el DPS intenta que la comunidad Sorda se convierta en sujeto político no subordinado y soberano, se visibilice y así forme parte de la agenda política. No habíamos encarado en los trabajos anteriores el análisis del texto como discurso argumentativo, y éste es el objetivo del presente trabajo. Creemos oportuno analizar desde el modelo propuesto por Stephen Toulmin  (2007\/1958), filósofo inglés, quien propuso un modelo de análisis de la forma lógica en los textos argumentativos que ha sido retomado por los analistas del discurso a fin de adaptarlo a cualquier tipo de textos (Pardo, 2011; Molina, 2012). Nuestra posición ni confusa ni ambigua como investigadores ha sido partir de un punto de vista etic o intercultural (creación del analista, clasificatorio), para llegar a realizar interpretaciones desde una perspectiva realmente emic, es decir intracultural (doméstica, descubierta por el analista y monocultural). Utilizamos un cuerpo de datos compuesto por videofilmaciones de señantes nativos (Sordos de segunda generación) de la Lengua de Señas Argentina (LSA) que pertenecen de manera activa a la comunidad Sorda. Dichos señantes son dos líderes políticos de la comunidad Sorda argentina. Estos registros visuales constituyen discursos producto de situaciones reales de intercambio que forman parte de dos eventos políticos trascendentales en la historia de la comunidad Sorda argentina: la CumbreLSA del año 2007 y la Audiencia Pública del año 2013. En el presente artículo, además, ha sido fundamental el cruce de la teoría de Toulmin con el marco teórico derivado de la teoría bachtiniana extendida en el contexto de una lingüística y una semiótica general, que ha permitido la reformulación del modelo de Toulmin desde una perspectiva interpretativista, a fin de poder entender la matriz textual en la que la comunidad Sorda está hoy inserta, así como la importancia del Discurso Político Sordo en la contingencia actual.","palabras_clave":"reformulación modelo de Toulmin|discurso político Sordo|Semiótica|argumentación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25244,"idioma_id":5,"titulo":"La dualidad del Problema de marco: Sobre interpretaciones y resoluciones","resumen":"El  problema  de  marco, interpretado como  un  problema  de  determinación  de  la relevancia,  ha  sido  motivo  en  las  décadas  de  los  80´-90´ de  grandes  debates  y controversias. La cuestión clave de este trabajo consistirá en dilucidar la relación que entre la dificultad definicional y resolutiva del problema de marco se establece: es necesario  aclarar  la  interpretación  particular que del problema de marco se  tenga en mente antes de estimar cualquier solución que intente resolverlo. Una manera de abordar esta cuestión es describir algunas de las varias interpretaciones que del problema se han propuesto y analizar luego las dificultades subyacentes. Al igual que Lormand (1991) sugerimos que cada una de estas interpretaciones se refiere a un problema distinto y que es necesario atender a las diferencias que entre éstas se establecen antes de estimar cualquier propuesta de resolución.","palabras_clave":"Problema de marco lógico|Problema de marco filosófico|Dificultad definicional|Dificultad resolutiva"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25276,"idioma_id":4,"titulo":"Quality maintenance of fresh-cut green and red bell pepper under controlled atmospheres.","resumen":"The responses of fresh-cut (FC) vegetables to CO2 and O2  levels depend on their ripening stage and degree of processing. In this work we  evaluated the effect of storage under different CO2 (2.5; 5; 10 and  15 kPa) and O2 (2.5 and 5 kPa) combinations or air on quality  retention of FC green and red pepper. Atmospheres with 15 kPa CO2 caused  physiological injury at both ripening stages. Red pepper strips were less  tolerant to CO2 enrichment within the range 5-10 kPa. Ripe FC  peppers were also more sensitive to O2 reductions below 5 kPa. Marked  benefits were obtained at both ripening stages with 5 kPa O2+5 kPa  CO2. CA-stored strips lower spoilage and dehydration and ion leakage.  Storage under 5 kPa O2+5 kPa CO2 was highly effective to  maintain the firmness and resistance to bending of the strips. The selected CA  caused no alterations in colour, acidity, sugars and antioxidants and was  effective to maintain lower respiration rate. CA was effective to maintain  lower counts of mesophilic bacteria, yeasts and molds in red ripe strips. ","palabras_clave":"pepper|fresh cut |quality|postharvest"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25355,"idioma_id":4,"titulo":"Enhanced transmission via evanescent-to-propagating conversion in metallic nanoslits: role of Rayleigh anomalies","resumen":"We analyze the enhanced transmission phenomenon in subwavelength slit structures near a dielectric interface. In particular, we investigate the influence of Rayleigh anomalies in the spectral position as well as in the bandwidth of Fabry?Perot resonances excited on such structures. We consider the cases of propagating and evanescent incidence, i.e., when themetallic structure is illuminated from the dielectric medium side with an incidence angle larger than the critical angle. We show that Rayleigh anomalies strongly interact with Fabry?Perot resonances, and make them deviate from the spectral positions predicted by the infinitely thin slit model. To get physical insight into this problem, we develop a simplifiedelectromagnetic model and show that there is a close correspondence between the transmitted response of the structure and the behavior of certain function that depends on the geometrical and the illumination parameters. Our results suggest that Rayleigh anomalies strongly modifythe electromagnetic response of the structure due to the existence of surface waves that modify the coupling condition between the fields inside and outside the slits. Besides, we show that even in absence of Fabry?Perot resonances, it is possible to produce enhanced transmission by taking advantage of the pseudoperiodicity condition of the fields.","palabras_clave":"PLASMONS|OPTICAL FORCES|NANOTUBES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25372,"idioma_id":5,"titulo":"Ángel, ¡qué raro! Perplejidades nominales en la poesía de Ángel González","resumen":"En el presente trabajo, nos centraremos en la relevancia del nombre de autor incluido en la obra poética del escritor asturiano, atendiendo a sus efectos y funcionamiento pragmático. En este repliegue discursivo sobre 'sí mismo', Ángel González (1925-2008) reivindica la posibilidad de plasmar una autorrepresentación, que excede con creces la mera remisión a la persona empírica, pues ésta sólo se comprende en el cruce de ambas esferas -privada y pública-, entre la proyección autobiográfica y la versión escrituraria. El orden social queda integrado a su autoanálisis, y dentro de él el propio sujeto que nos cuenta su vida, al tiempo de advertirnos sobre los límites de tal gesto, por su estatuto verbal e imaginario.","palabras_clave":"POESIA ESPAÑOLA CONTEMPORANEA|ANGEL GONZALEZ|NOMBRE PROPIO|PERSONAJE POÉTICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25414,"idioma_id":5,"titulo":"Las prácticas de lectura en el entorno digital: industria editorial, mercado y consumo","resumen":"Si bien la industria editorial ha atravesado grandes trasformaciones con la incorporación de las tecnologías de la información y la comunicación (TIC) en el ámbito de la producción, tanto editorial como autoral, el presente artículo atiende particularmente a las nuevas características que presentan las prácticas de lectura a partir de dicha inscripción. Se propone aquí un análisis de la cuestión de la lectura en estricta relación al nuevo escenario editorial marcado por un continuo replanteo del ?quehacer editorial?, del rol del editor y los diversos agentes del campo, de los soportes y formatos válidos para la lectura. La primera sección propone una sintética caracterización del funcionamiento de la industria editorial. El segundo apartado hace foco en las transformaciones puntuales del sector del libro en relación con la llegada de las tecnologías de la comunicación. La tercera parte presenta un breve repaso del estado de la cuestión vinculado a las prácticas de lectura en el entorno digital, y a continuación se desarrollan algunos rasgos y tendencias de la lectura en los soportes electrónicos en Argentina, Estados Unidos y España. El artículo concluye con una serie de reflexiones finales.Revista indexada en: Latindex, Modern Language Association.","palabras_clave":"INDUSTRIA EDITORIAL|PRACTICAS DE LECTURA|NUEVAS TECNOLOGÍAS|LIBRO ELECTRÓNICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25419,"idioma_id":4,"titulo":"Plasma cholesterol increase in rats with modified lipid enriched diets. Blood fluidity analysis","resumen":"To obtain an increase of plasma cholesterol in rats to study the effect of different hypocholesterolemic agents, the animalswere fed with two different diets analyzing the factors acting upon blood fluidity. Male Wistar rats aged 70 days (n=24),were allocated to 3 groups and fed during 28 days as follows: 1) Standard diet (C); 2) Standard diet added (D1) with 15%bovine juice (100g: 1.2g Cho, 1.06g total lipids and 6.8g proteins), and 3) Standard diet added (D2) with 0.8g 97% pureCho and 28% wheat oil (W\/W). The rats were anesthetized with sodium pentobarbital (50 mg\/kg b.w., i.p.) to draw bloodby cardiac puncture. Plasma assays: Cho, HDL-Cho, and LDL-Cho. Blood assays: total blood viscosity (TBV) and plasmaviscosity (PV). Standardized relative BV (SBV) at 45% hematocrit [(BV\/PV)45\/Hto]; rigidity index (RI) the inverse oferythrocyte deformability (ED); cell shape and the corresponding morphological index (MI). Statistics: ANOVA and posthoc Tukey?s test. Results: (mean±SD): Cho (mg %): C:85.99±3.29;D1:77.17±2.61; D2:104.87±2.39**;HDL-Cho (mg%):C:56.17±4.12;D1:66.14±3.23;D2:79.12±1.57**; LDL-Cho (mg%): C:13.99±0.89; D1:13.67±0.67; D2:34.25±1.982**;SBV: C:4.26±0.9; D1:4.85±0.41; D2:6.56±0.18**. RI: C: 5.79±0.18; D1:6.06±0.17; D2:8.77±0.31** MI: C:-0.49±0.04;D1:-1.397±0.11**; D2:-2.458±0.12**; (** p<0.001 vs. C). Only D2 showed an increase of plasma Cho, HDL-Cho, andLDL-Cho, and an increase of SBV due to a decrease of ED, therefore an IR increase. The diminution of the MI points outthe existence of lower ED coincident with a SBV. The increase of Cho in plasma leads to a higher relationCho\/phospholipids membrane diminishing the red blood cells deformability","palabras_clave":"CHOLESTEROL|DIETS|LIPID ENRICHED |BLOOD FLUIDITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25424,"idioma_id":5,"titulo":"La Teorìa General del Derecho como asignatura necesaria del Plan de Esudios de la Carrera de Abogacìa.","resumen":"Las ramas jurídicas son estudiadas por  el estudiante de Abogacía en asignaturas separadas a lo largo de la carrera. Ahora  bien, es necesario una asignatura al final de la misma que reúna a todas las  ramas del Derecho estudiadas separadamente. Es decir, una visión de síntesis  de todas las ramas del mundo jurídico. Esa asignatura necesaria es la Teoría General del Derecho. La misma aporta la noción de ?unidad? del fenómeno  jurídico, es decir, la comprensión del Derecho como ?sistema jurídico?.        Permite al estudiante avanzado la  reflexión superadora de las particularidades de cada rama del Derecho y el  enfoque de lo ?común? y lo ?abarcativo? de todo el fenómeno jurídico. La  asignatura debe constituirse en el camino para que el alumno avanzado de  Derecho logreautónomamente  la comprensión y reflexión de: la noción de unidad del Derecho, la finalidad del  Derecho, la idea de cambio en el Derecho, la noción de complejidad pura del  Derecho, la noción  de rama jurídica, la noción de autonomía de las ramas, la crisis de las  respuestas que brindan  las ramas jurídicas tradicionales, y el replanteo sobre la necesidad de  surgimiento de nuevas  ramas jurídicas.","palabras_clave":"Teorìa General del Derecho|asignatura necesaria|Abogacìa|Filosofìa del Derecho"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25466,"idioma_id":5,"titulo":"¿Veinte años no es nada? Un estudio de los debates constituyentes de 1994 sobre ambiente y patrimonio cultural","resumen":"El objetivo de la presente contribución consiste en revisitar algunas problemáticas que formaron parte de los debates constitucionales desarrollados en el contexto de la reforma de 1994 y, en particular, sobre algunos aspectos del texto del artículo 41 incorporado en el apartado Nuevos Derechos y Garantías. A partir del análisis de un corpus de documentos conformado por las versiones taquigráficas de los debates producidos en el seno de la Convención Constituyente se pretende recuperar algunos interrogantes que interpelaban a los constituyentes, en especial respecto de la perspectiva ética subyacente para pensar la problemática ambiental así como sobre el concepto de patrimonio cultural. Este rescate se realiza desde un enfoque histórico y, al mismo tiempo reconsiderando críticamente las perspectivas y conceptos a través de los cuales procuraron darles respuesta a la luz de debates y miradas contemporáneas que poseen especial relevancia en el ámbito latinoamericano.\/\/ La Revista de la Facultad de Ciencias Jurídicas y Sociales se establece como un ámbito de publicación para docentes e investigadores de dicha institución de la Universidad Nacional del Litoral.","palabras_clave":"Derecho |Constitución Nacional |ambiental"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25520,"idioma_id":4,"titulo":"A Branch-and-Price Approach To Manage Cargo Consolidation and Distribution in Supply Chains","resumen":"The optimization of an enterprise supply chain requires reducing costs and inventories. An usual way to increase the efficiency of the supply chain is to outsource the movement of shipments on third parts logistics companies (3PL). In turn, 3PL companies are required to consolidate shipments from different suppliers in the outbound vehicles at a terminal of the carrier terminals-network. Services to manufacturing enterprises are differentiated into two groups regarding the shipment size. Manufacturers contract full-truckload (FTL) carriers when a shipment is large enough to fill a vehicle whereas less-than-truckload (LTL) carriers are used for minor shipments. LTL carriers must convey a number of transportation-requests from the origin locations to their destinations while minimizing the total movements-cost by using the possibility of goods-transshipments on the carriers terminals-network. We present a methodology for finding near-optimal solutions to a problem related to LTL-shipping by using column generation combined with a customized branch-and-price procedure. The approach rapidly provides near-optimal solutions since it solve the column generation subproblems approximately and do not necessarily consider all unexplored nodes in the search-tree. We also present computational results on numerous test problems of varied topologies and on a real case study.","palabras_clave":"supply chain|less-than-truckload|multiple delivery options|branch-and-price|multiple pricing problems"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25533,"idioma_id":4,"titulo":"An approach to benchmarking of loosely coupled low-cost navigation systems","resumen":"New solutions to the navigation problem related to low-cost integrated navigation systems (INS) are often published. Since these new solutions are generally compared with ad hoc mathematical models that are not fully exposed, one cannot be sure of the relative improvements. In this work, complete mathematical model for a low-cost INS is suggested to be used as a benchmarking. As far as the authors? knowledge, a benchmarking for low-cost INS has not been previously reported. Shown INS comprises a strapdown inertial navigation system, loosely coupled to a GPS receiver. The INS mathematical model is based upon classical navigation equations and classical sensor models, both from recognized authors. The algorithm that details the INS operation is also presented. The benchmarking is provided as an open-source toolbox for MATLAB. Additionally, this work can be taken as a starting point for new practitioners in the INS field. To validate the INS mathematical model, real-world data sets from three different Micro Electro-MechanicalSystems (MEMS) inertial measurement units (IMU) and a GPS receiver are processed. It is observed that obtained RMS errors from the three INS are coherent with the quality of corresponding MEMS IMU. This confirms that the proposed benchmarking is a suitable tool to evaluate objectively new solutions to low-cost INS.","palabras_clave":"navigation|system modelling|inertial sensors|signal and information processing|aerospace systems|robotic systems"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25554,"idioma_id":4,"titulo":"Activation of spleen tyrosine kinase (Syk) at fertilization in Rhinella arenarum eggs","resumen":"Recently, we have provided evidence suggesting the involvement of a cytosolictyrosine?phosphorylatable 70 kDa oocyte protein in Rhinella arenarum (Anura:Bufonidae) fertilization. The aim of this work was to characterize its phosphorylation,determine the identity of this protein and establish a biological role during thefertilization process. Tyrosine phosphorylation of the 70 kDa protein was not observedin eggs activated with calcium ionophore A23187. Pretreatment of oocytes with thetyrosine kinase inhibitor genistein effectively blocked the fertilization-dependentphosphorylation of the 70 kDa protein. In order to identify this protein, we examinedthe presence in amphibian oocytes of non-receptor 70 kDa tyrosine kinase members ofthe Syk\/Zap70 and Tec families by RT-PCR using degenerate primers. We found that R.arenarum oocytes contain the transcripts coding for Syk and Tec kinases. Western blotanalysis confirmed the presence of Syk protein in unfertilized oocytes and eggs. Studiesusing phospho-Syk specific antibodies showed that fertilization rapidly (less than 10minutes) induces phosphorylation on Syk tyrosine residues (352 and 525\/526) that arenecessary for the activation of the enzyme. Finally, specific inhibition of Syk with theR406 compound provoked a diminished fertilization score, allowing us to confirm afunctional role of the Syk protein during R. arenarum fertilization. To our knowledgethis is the first time that Syk is described as a player in the signaling cascade activatedafter fertilization.","palabras_clave":"FERTILIZATION|SPLEEN TYROSINE KINASE|AMPHIBIAN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25564,"idioma_id":5,"titulo":"Reseña de Salrach, Joseph, El hambre en el mundo. Pasado y presente, PUV, Valencia, 2012.","resumen":"Reseña bibliográfica del libro indicado.","palabras_clave":"SALRACH|HAMBRUNAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25698,"idioma_id":5,"titulo":"Medios de comunicación y sentimiento de inseguridad: un recorrido por sus abordajes y nuevas preguntas","resumen":"Este artículo pretende discutir con un modo específico ? y mayoritario- en que se define la relación entre medios de comunicación y sentimiento de inseguridad en nuestro país que vamos a denominar como determinismo mediático. Se trata de poner en cuestión una suerte de determinismo que, por un lado reduce el aspecto subjetivo de la seguridad al miedo al delito, y por otro, atribuye a los medios una suerte de causalidad en los modos de experimentar la inseguridad. Para ello, se recuperan los abordajes de la criminología para pensar la relación entre medios y la faz subjetiva de la inseguridad; se realiza un recorrido por los estudios de comunicación, y luego por los aportes de otras ciencias sociales argentinas para indagar cómo se plantea este vínculo. Como cierre, se proponen algunos interrogantes que se abren a partir de la sistematización y de la puesta en diálogo de diferentes campos de conocimiento.","palabras_clave":"seguridad|medios de comunicación|mediatización|sentimiento de inseguridad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25799,"idioma_id":5,"titulo":". LA SUBJETIVACIÓN POLÍTICA EN LAS FÁBRICAS MILITARES CORDOBESAS DURANTE EL PRIMER PERONISMO","resumen":"Presentamos un estudio comparado de los procesos de subjetivación política en las fábricas militares de Río Tercero y Villa María (Córdoba) durante los dos primeros gobiernos peronistas. Mostramos cómo la implantación de estas fábricas nacidas de un proyecto estratégico industrial estatal, con formas de reclutamiento y proletarización similares, genera distintas modalidades de subjetivación política. Sostenemos que las características de los entramados urbanos en los que se insertan, incluyendo la vida política previa, los circuitos extraproductivos ligados a la fábrica y la organización del trabajo modelan otras prácticas sindicales. Postulamos, siguiendo a Soul, la noción de ?comunidad de fábrica? para dar cuenta de la estructura mítica que genera un sentido de pertenencia que enmascara las diferencias estructurales. Mostramos cómo tal comunidad se agrieta en Villa María permitiendo que emerja la resistencia que se hará sistemática en los 60-70. En Villa María la experiencia de diversidad de escenas sociales por las que transitan los operarios posibilita construir una tradición de lucha con rasgos antagónicos, a lo que se suma una organización del trabajo que llamamos de ?proceso discontinuo? que permite trazar, aún con contornos difusos, la figura de un patrón con el que se confronta. En los trayectos históricos las prácticas sindicales de ambos emprendimientos resultan disímiles, aunque el mismo gremio ?Asociación de Trabajadores del Estado- acoja a ambos colectivos.","palabras_clave":"fabricaciones militares|subjetivación política|peronismo|Villa María y Río Tercero"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25961,"idioma_id":5,"titulo":"LOS MERCADOS VIRTUALES COMO CONTRASTE DE LOS MERCADOS FINANCIEROS","resumen":"RESUMEN¿Se comportan los mercados de las economías virtuales de forma similar a los mercados financieros reales? Dado que los primeros son pequeños con bienes y servicios finitos, surge la posibilidad de estudiarlos como si setrataran de abstracciones de la realidad o modelos de textos de economía y finanzas que cumplen supuestos imposibles en la realidad. Entonces, se procurará extrapolar y comparar el comportamiento de los agentes en ellas, con el de los mercados financieros para observar características, diferencias y similitudes. Con esto, se pretenden distinguir las raíces fundamentales del comportamiento económico, es decir las características y conceptos que definen un mercado financiero, y por otra parte, reflejar que estos son entidades abstractas quese concretan en cualquier ámbito, sin tener un respaldo real. Para ello, será necesario entender y conceptualizar los componentes fundamentales de un mercado y realizar una evaluación de eficiencia y asignación óptima en todos los casos con el fin de corroborar la hipótesis presentada.Palabras clave: economías virtuales, mercados financieros, comportamiento económico.","palabras_clave":"ECONOMIAS VIRTUALES|MERCADOS FINANCIEROS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":25999,"idioma_id":5,"titulo":"Requerimiento energético en adolescentes: estudio a partir de fórmulas predictivas y consumo calórico","resumen":"Las diferentes etapas del desarrollo humano precisan de aportes nutricionales adaptados a cada momento. Los requerimientos energéticos en la adolescencia son significativamente mayores que en cualquier otra etapa y pueden estimarse por el método factorial que supone la suma de metabolismo basal, la actividad física, la termogénesis inducida por la dieta y el costo energético del crecimiento. El objetivo del presente trabajo es analizar dicho requerimiento energético en adolescentes de una escuela secundaria pública a partir de fórmulas predictivas y compararlo con el consumo calórico de los participantes. Se realizaron encuestas en forma individual, recordatorio de 24 horas y se tomaron medidas antropométricas. Se llevó a cabo un estudio descriptivo de tipo transversal, combinando metodología cuali y cuantitativa para analizar los resultados. Los principales resultados muestran que el 70% de los participantes que cubren el requerimiento, excede en más de 300 kcal. las exigencias energéticas nutricionales propias de la edad.","palabras_clave":"REQUERIMIENTOS ENERGÉTICOS|FÓRMULAS PREDICTIVAS|CONSUMO CALÓRICO|ADOLESCENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26024,"idioma_id":4,"titulo":"Influence of the interaction between phosphate  and arsenate on periphyton?s growth and its  nutrient uptake capacity","resumen":"Periphyton communities grown in microcosms were studied under the exposure to different arsenate (As) and phosphate (P) regimes with the aim of revealing the effect of chronic exposure to As on periphyton physiological and structural characteristics. Also, we aimed to study   periphyton changes on sensitivity to As, exposed to different P and As regimes. As affected structural and functional parameters of periphyton communities starved of P, inhibiting algal growth, photosynthetic capacity, changing community composition and reducing the ability of the   community to retain P. Effects of As on these parameters were only detected in P starved communities, showing that chronic exposure to As led to changes in the photosynthetic apparatus under conditions of P-limitation, but not when P-availability was higher. This fact reveals a lower toxicity and\/or a higher adaptation of the P-amended community. Intracellular As contents were higher in communities starved of P. However, As tolerance was only induced by the combination of As and P but not by As or P alone indicating that tolerance induction may be an ATP-dependent mechanism. This study reveals that chronic exposure of natural communities to environmentally realistic As concentrations will damage periphyton communities affecting a key ecosystem processes, as P uptake, leading to changes in stream ecosystems, as these organisms play a key   role in nutrient cycling through nutrient uptake and transfer to higher trophic levels.","palabras_clave":"biofilm|arsenic|phosphate|stream|ecotoxicology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26028,"idioma_id":5,"titulo":"Suerte moral y subjetivismo penal. El problema del error in personam y el aberratio ictus","resumen":"El problema de la suerte moral ha originado debates entre filósofos y teóricos penales. En este trabajo intentaré introducir el problema y luego me voy a concentrar en la regulación de circunstancias específicas del derecho penal, que se vinculan con la suerte, como el aberratio ictus y el error in personam. Mi objetivo, en este trabajo, es señalar las dificultades que tienen aquellos que pretenden negar la influencia de la suerte en nuestras vidas.","palabras_clave":"ABERRATIO ICTUS|ERROR IN PERSONAM|CASTIGO|SUBJETIVISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26029,"idioma_id":5,"titulo":"Retribución, Inculpación y ¿Perfeccionismo moral?","resumen":"Carlos S. Nino presentó en sus últimos trabajos una defensa de su teoría del castigo que incluía una profunda crítica al retribucionismo. Según su posición si adoptáramos una teoría retribucionista del castigo, estaríamos asumiendo una versión del subjetivismo penal que abraza el perfeccionismo moral. Nino presenta esta idea sugiriendo que hay un vínculo estrecho entre el retribucionismo, el subjetivismo y el perfeccionismo. En este trabajo, voy a discutir esa relación y criticar el nexo que Nino cree que existe entre ellos.","palabras_clave":"RETRIBUCION|INCULPACION|PERFECCIONISMO|LIBERALISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26092,"idioma_id":4,"titulo":"The Maximum Number of Dominating Induced Matchings","resumen":"A matching M of a graph G is a dominating induced matching (DIM) of G if every edge of G is either in M or adjacent with exactly one edge in M. We prove sharp upper bounds on the number µ(G) of DIMs of a graph G and characterize all extremal graphs. Our results imply that if G is a graph of order n, then µ(G)=9 and G is connected.                                           REFERENCES:[1] A. Brandstädt, C. Hundt, and R. Nevries, Efficient edge domination on hole-free graphs in polynomial time, Lect Notes Comput Sci 6034 (2010), 650-661.[2] A. Brandstädt, A. Leitert, and D. Rautenbach, Efficient dominating and edge dominating sets for graphs and hypergraphs, Lect Notes Comput Sci 7676 (2012), 267-277.[3] A. Brandstädt and R. Mosca, Dominating induced matching for P7-free graphs in linear time, Lect Notes Comput Sci 7074 (2011), 100-109.[4] D. M. Cardoso, J. O. Cerdeira, C. Delorme, and P. C. Silva, Efficient edge domination in regular graphs, Discrete Appl Math 156 (2008), 3060-3065.[5] D. M. Cardoso, N. Korpelainen, and V. V. Lozin, On the complexity of the dominating induced matching problem in hereditary classes of graphs, Discrete Appl Math 159 (2011), 521-531.[6] D. M. Cardoso and V. V. Lozin, Dominating induced matchings, Lect Notes Comput Sci 5420 (2009), 77-86.[7] D. L. Grinstead, P. J. Slater, N. A. Sherwani, and N. D. Holmes, Efficient edge domination problems in graphs, Inform Process Lett 48 (1993), 221-228.[8] N. Korpelainen, A polynomial-time algorithm for the dominating induced matching problem in the class of convex graphs, Electron Notes Discrete Math 32 (2009), 133-140.[9] M. C. Lin, M. J. Mizrahi, and J. L. Szwarcfiter, An inline image time algorithm for minimum weighted dominating induced matching, Lect Notes Comput Sci 8283 (2013), 558-567.[10] M. Livingston and Q. F. Stout, Distributing resources in hypercube computers, Proceedings of the 3rd Conference on Hypercube Concurrent Computers and Applications, ACM, 1988, pp. 222-231.[11] C. L. Lu, M.-T. Ko, and C. Y. Tang, Perfect edge domination and efficient edge domination in graphs, Discrete Appl Math 119 (2002), 227-250.[12] C. L. Lu and C. Y. Tang, Solving the weighted efficient edge domination problem on bipartite permutation graphs, Discrete Appl Math 87 (1998), 203-211.","palabras_clave":"Dominating induced matching|Fibonacci numbers"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26163,"idioma_id":4,"titulo":"Omega-3 Fatty Acids and Anhedonia in a Hormonally Induced Pospartum Depression Model. Biocell","resumen":"Soria JC, Fracchia LN. Omega-3 Fatty Acids and Anhedonia in a Hormonally Induced Pospartum Depression Model. Biocell. Pág 8 ISSN 0327-9545","palabras_clave":"DEPRESIÓN POSTPARTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26165,"idioma_id":4,"titulo":"HEIGHT APEX, INDEX DMF AND CONSUMPTION OF FOOD NIGHT BRUSHED POST IN THREE SUBPOPULATIONS OF ROSARIO CITY.","resumen":"              HEIGHT APEX,  INDEX DMF AND CONSUMPTION OF FOOD NIGHT BRUSHED POST IN THREE SUBPOPULATIONS OF  ROSARIO CITY.              Beltrandi R, Merello J, Kohli, A.              Escuela &nbsp;de&nbsp; Odontología;  &nbsp;&nbsp;Instituto&nbsp; Universitario&nbsp;  Italiano&nbsp; de&nbsp; Rosario.&nbsp;  ramirobeltrandi@hotmail.com.               Caries is an  infectious disease multifactorial that depends on the interactions between the  hard tissue of the tooth, the metabolic products of the diet and the  biochemical in the bacterial plate when it is not removed, for the brushed one.  It is related to the dental anatomy, consume of sugars and habits of oral  hygiene. The dental anatomy with sharp apexes and deep ruts they are ecological  niches for the accumulation of bacterial plate. A way of quantifying the  dynamics of the caries is the index DMF&nbsp;  that he considers to the tooth as a unit. The consumption of sugary food  brushed night post, favors the production of acids for the mouth flora. The aim  of the present study was to relate the index DMF, height apex and consume of sugars  post brushed nocturne in assistants to Centers of Dental Attention in different  areas of our city. With a standardized anamnesis there were investigated  information of age, sex, index DMF, height apex classified in sharp and low, consume  of adhesive food brushed night post in 15-45-year-old persons of Rosario´s  city. One worked with following institutions: 1) private attention; 2) public:  a) of the provincial area; b) of the municipal area. Of the total, 333 persons,  22 % was particular, 26% municipal and 52% to the provincial hospital (p  &lt;0,001); average age 32 years in the private one, 24 in municipal and 26 in  the provincial area; 34 % of males and 66 % of women (p &lt;0,001). Average DMF  private group 25 ±4,26, municipal 23 ±4,34 and provincial 25 ± 4,10. Sharp  apexes 11 % and lower 82 % in the private service; 13 % and 80 % in the municipal  and 26 % and 69 % in the provincial area respectively (p=0,095). In the private  one, the food consumption post brushed nocturne was 43 %; in municipal of 65%  and in the provincial area of 52 % (p=0,018). The average level of the Index DMF  does not present significant differences between the different groups. Our  population was integrated wholesale proportion of young women. There was  majority of low apexes in three sub-populations, therefore this variable would  not be a factor of risk for the development of caries. Difference was not  situated with regard to the indexes DMF, it would be of usefulness to  discriminate between decayed, lost and plugged teeth. The consumption of sugary  food brushed night post, was minor in the private sector, showing it differs  from behavior between services being a factor of risk for the dental health in  the public services.  ","palabras_clave":"DENTAL ANATOMY|CARIOGENIC DIET"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26167,"idioma_id":4,"titulo":"ODONTOBLASTIC  CHANGES   ON  DENTAL  PULP  FROM  GERMS  AND   MOLAR   WITH  TWO  DIETS.","resumen":"        ODONTOBLASTIC &nbsp;CHANGES &nbsp;&nbsp;ON &nbsp;DENTAL &nbsp;PULP &nbsp;FROM &nbsp;GERMS &nbsp;AND &nbsp;&nbsp;MOLAR &nbsp;&nbsp;WITH&nbsp; TWO &nbsp;DIETS.Dávila H1, Zapata N3, Zaffaroni  M3, Kohli A2-3.        Consejo  de &nbsp;Investigaciones1, &nbsp;Facultad Odontología2, UNR. IUNIR3. Aliciakohli2009@hotmail.com        &nbsp;        &nbsp;Odontoblasts, dental pulp &nbsp;synthesize predentine primary, secondary and tertiary by caries or  external stimuli. Objetive: to stimulate &nbsp;the &nbsp;synthesis&nbsp; with a  sugary diet by evaluated changesin &nbsp;odontoblasts in touch. Eighteenrobust rats line'l' and fifteen small line 'e'&nbsp; were subjected to usual diet nine and six (G1) and cariogenic,  water with 10%  sucrose, nine in each line (G2),  sacrificed in three weeks, excised jaws,demineralized, removed collagen &nbsp;and stained with  H&amp;E. With MO 1000  X,&nbsp;&nbsp; predentine  type, perimeter thickness classifyingin thin (1-2rows of odontoblasts) and thick (3 and morerows), spaces between them in few and many; &nbsp;size in small and largeand its &nbsp;connection with similar in th e pulp. Fisher&nbsp;&nbsp;test. In 17 dental pulps germs,100% primary&nbsp; both lines and groups are found; line'l' thin perimeter both groups; on line 'e',thin in G1and thick on G2; at regular intervals some few and small spaces  united a &nbsp;similar in dental  pulp. On line 'l' 14  days: 35 molar, both groups,  there was &nbsp;&nbsp;secondary (p=0.007) and tertiary(p=0.03); in the  first&nbsp; few and  small spaces between them, 100% united  a pulp in G1 and 28% in G2. In tertiary was100% many and smallspaces all united in G1, at 15% in G2, 54% small , united 46%.  21 days: 32 pulps  with tertiary (p=0.009);  few 50%, 60% small, 90% united &nbsp;in G1,  33% few, 78% small,67% united in G2.  28 days: in 38 molars &nbsp;secondary; 57% few, 93% small, 64%  united in G1, few 36%, small 100% and78% united in G2.  Line 'e' 28 days: in 33, secondary (p=0.004), 57% few, 93%small, 64% united in G1, 36% few, 100% small, united 78%in G2. In germ line 'l'  G1, the primary with thin perimeter; on line 'e'G2 this was  higher by effect diet and robustless;  spaces small united to pulp both lines and  groups. In molars, both lines, predentine was  accompanied by thin G1 and thickG2 perimeter. In different proportions small  spaces united to the pulp. Spaces  between odontoblasts were affected in &nbsp;size, number and union a  &nbsp;pulp.        &nbsp;  ","palabras_clave":"ODONTOBLAST|DENTAL GERMS|CARIOGENIC DIETS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26168,"idioma_id":4,"titulo":"DIETETIC HABIT,  EDUCATIONAL LEVEL  AND DMF  IINDEX:  IN ISLANDER WOMEN   OF  COAST  AND NEIGHBORING   ISLANDS.","resumen":"    DIETETIC HABIT, &nbsp;EDUCATIONAL  &nbsp;LEVEL &nbsp;AND &nbsp;DMF &nbsp;INDEX: &nbsp;IN&nbsp; AISLANDER WOMEN &nbsp;&nbsp;OF &nbsp;COAST&nbsp; AND NEIGHBORING&nbsp;&nbsp; ISLANDS.Esteve S1, Fournier M1, García B1,  Merello J1, Kohli A1-2.     Instituto Universitario Italiano de Rosario1. Facultad&nbsp;  Odontología; UNR2. Aliciakohli2009@hotmail.com     &nbsp;The islander women living far from dental centers lapsing pregnancy  and lactation, with mobilization  of their calcium and phosphate of bones and teeth for children´s  development and quality of their milk,receive these components if incorporated milk to your diet. Objective: to  study milk consumption habits, educational level  and oral status with  DMF index. A standardized anamnesis, from 15-45 years,  living in the 'coast', concurrenturban dental care centers and the 'Backwater Valerio', inhabiting islands 'Charigüé' and 'Wintering 'with&nbsp; school, both without dentist were applied. Pregnancies,  maternal adherence to breastfeeding,  milk consumption, formal study years  separated in GA up to 6 years and GB up to 12 years or more.  &nbsp;DMF index was obtained in each group by level of study. Fisher&nbsp; analysis. Total interviewed: 40% were women'coast', mean age 30 years;  was raised from one to four children, nursed 75%;  'Charigüé' 47% women; average age 32; was  raised from one to eight children;  nursed 100%; in'Wintering', 45% women,  mean 31 years, with one to four children; nursed 100% (p=0.5); milk consumption: in the 'coast  'never consumed 25%, sometimes and  everyday 37.5% respectively;  'Charigüé' sometimes 57% and daily 43%;  'Wintering' sometimes 40%and daily 60% (p= 0.43); 'coast'  education -GA, 50%, DMF index 5.25; -GB 50%, &nbsp;DMF 11.75; 'Charigüé' -GA 29% , DMF 22; -GB 71, &nbsp;DMF 6.6; 'Wintering' -GA 20%, &nbsp;DMF 8; -GB 80%, DMF 6 (p= 0.029). In the 'coast' was less consumption of milk, pregnancy and  nursed; more availability of schoolsbut the education did nothing to diminish the value of the index. On islands with schools  by not dental centers,  women consumed more milk, crossed pregnancies and nursed and a higher educational level minor index value.    &nbsp;  ","palabras_clave":"DIETETIC HABITS|EDUCATIONAL LEVEL|DENTAL INDEX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26239,"idioma_id":5,"titulo":"La oportunidad y los sujetos de la evaluación en políticas públicas: Una aproximación a dos casos de estudio en Córdoba Ciudad","resumen":"Durante décadas la opción simplificadora en el análisis de políticas públicas ha sido la 'heurística por etapas', que remitió la evaluación al último momento de la política en un contexto de desatención y de implementación de arriba hacia abajo. También mucho se discute acerca de la naturaleza ideal del evaluador, su involucramiento\/distanciamiento respecto del proyecto y los intereses que la política materializa. En este trabajo buscaremos respuestas en torno de los dos aspectos mencionados: la oportunidad (¿cuándo?) y los sujetos (¿quién\/es?) de la evaluación. Para tal fin problematizamos dos casos: el Plan de Metas de Gobierno y los Centros Integradores Comunitarios, donde identificamos algunas ventanas de oportunidad para la evaluación permanente de las políticas y la multiplicación de los actores implicados en la misma.","palabras_clave":"DELIBERACIÓN PÚBLICA|EVALUACION DE POLÍTICAS|PARTICIPACIÓN CIUDADANA|CENTROS INTEGRADORES COMUNITARIOS|PLAN DE METAS DE GOBIERNO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26388,"idioma_id":4,"titulo":"Kinectics of Na+ , K+ -ATPase inhibition by calcitonin and neurotensin","resumen":"The kinetics of interactions between the peptides  calcitonin or neurotensin, and synaptosomal  membrane Na+  , K+  -ATPase activity was characterized  in this study. Calcitonin is a 32-amino acid peptide  produced by the thyroid gland, whose main role is  to prevent bone resorption. Calcitonin produced  a non-competitive type of inhibition at varied  potassium concentrations whereas in the presence  of sodium and ATP, calcitonin produced an  uncompetitive and competitive type of inhibition,  respectively. Neurotensin is a basic tridecapeptide  which also inhibits Na+  , K+  -ATPase activity.  Therefore, in the presence of higher sodium  concentrations the peptide produced a competitive  interaction and it produced a non-competitive  type of inhibition at varied potassium and ATP  concentrations. In summary, calcitonin and neutotensin  behave as enzyme inhibitors but, each one leads  to a characteristic type of enzyme inhibition at  varied substrate concentrations due to differences  in peptide structure and functionality that could be  influencing the kinetics of substrate interactions","palabras_clave":"Na+ , K+ - ATPase |ENZYME KINECTICS|NEUROTENSINA|CALCITONIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26446,"idioma_id":4,"titulo":"Effect of nerve stimulation in the amphibian oviduct secretion","resumen":"Previous work in our laboratory showed that the Rhinella arenarum oviduct is innervated by the autonomic nervous system. Based on the above, the aim of this study was to determine the effect of nerve stimulation on the secretory cells of the oviduct of adult females captured during the breeding period of the species. For this, same animal was used as control and experimental. Once exposed oviducts one of them was stimulated with an electrical stimulus of an intensity of 7 mA, a frequency of 10 Hz for 1 min on nerves that run through the mesentery, while the control duct was preserved of the stimulus. Subsequently pars convolute (PC) samples of the two oviducts were taken and then fixed and processed following routine techniques for transmission electron microscopy.   Observations have revealed that in the oviduct stimulated:   a-secreting epithelial cells, loaded with secretory granules, are located near the surface and even protrude into the lumen of the duct. Secretion of these cells includes flocculent material and granules.   b-The glandular secretory cells release only secretory granules many of then show an electron-dense core.   c-The release of cell contents would be carried out mainly by merocrine mechanism, however apocrine or holocrine secretion it was observed also in some cells.   d- At the duct lumen level the secretion exhibit structured materials (granules of various shapes, sizes and electrodensity with and without dense core) as well as unstructured ones with flocculent appearance.   Ultrastructural analysis allow us to suggest that stimulation of autonomic nerves innervating the oviduct promotes the release of contents from both epithelial secretory cells as well as glandular secretory cells in the oviductal mucosa.","palabras_clave":"AMPHIBIAN|OVIDUCT |SECRETION|NERVE STIMULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26511,"idioma_id":5,"titulo":"ANÁLISIS DE ESCENARIOS PARA EVALUAR LA IMPLEMENTACIÓN DE MEDIDAS DE AHORRO ENERGÉTICO EN EL SECTOR TABACALERO DE LA PROVINCIA DE SALTA","resumen":"En la Provincia de Salta, la producción de tabacoconstituyeuna las principales actividades económicas,posee unelevado consumo energético y es susceptible de mejoras.En el marco del paradigma de la sustentabilidad en la actividadmencionada cobran relevancia la eficiencia energética y la incorporación de energías renovables en la actividad. El presentetrabajo se propone evaluar el impacto de dos estrategias de ahorro energético para el sistema de producción de tabaco en laProvincia de Salta, a partir de análisis de escenarios prospectivos. Las estrategias de mejora se validaron mediante consulta alos actores involucrados en la temática y para la construcción de escenarios se utilizó el software LEAP.Los indicadoresenergéticos y ambientales demuestran que de no implementarse estrategias de ahorro energético los impactos acumulados(estimados a parir de la huella de carbono) alcanzaran las 1.417,214 Millones de Toneladas de CO2eq. En este sentido elincremento de la demanda energética a futuro puede acrecentar los conflictos sociales derivados del costo de oportunidad delrecurso y generar externalidades. Por ello resulta primordial llevar a cabo un proceso de planificación energética, en el cual seintegre al sector tabacalero.","palabras_clave":"PLANIFICACIÓN ENERGÉTICA|ENERGÍA SOLAR|SUSTENTABILIDAD|ESCENARIOS ENERGÉTICOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26566,"idioma_id":5,"titulo":"...fuese y no hubo nada. Cervantes frente a la manipulación y la dilapidación simbólica.","resumen":"El soneto de Cervantes ¡Voto a Dios que me espanta esta grandeza! retrata, antes que nada, un juego de reacciones frente a un artefacto simbólico construido con el claro fin de exaltar el poder monárquico en la España de fines del siglo XVI. Resulta entonces un objeto de análisis muy interesante para sondear el diálogo de Cervantes con las prácticas manipuladoras que eran inherentes a la cultura simbólica de su época.","palabras_clave":"CERVANTES|POESIA|HONRAS FÚNEBRES|RECEPCIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26728,"idioma_id":5,"titulo":"La radicalización del élenchos: el recurso a la verdad como condición dialéctica mínima en el Teeteto de Platón","resumen":"En la primera parte del Teeteto Sócrates refuta tres tesis que considera estrechamente vinculadas entre sí: la tesis de Teeteto que identifica conocimiento y percepción, la tesis relativista y la tesis movilista. El propósito de este trabajo es mostrar que en tres de las refutaciones ofrecidas contra estas posiciones se exhibe una misma estrategia tendiente a remitir a un prerrequisito dialéctico vinculado a la pretensión de verdad. Esta constituiría una estrategia radical, en el sentido de que pone en cuestión la misma posibilidad de emitir la propia tesis por parte del adversario.","palabras_clave":"élenchos|Platón|Teeteto"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26782,"idioma_id":4,"titulo":"Mining the Modular Structure of Protein Interaction Networks","resumen":"Background      Cluster-based   descriptions of biological networks have received much attention in   recent years fostered by accumulated evidence of the existence of   meaningful correlations between topological network clusters and   biological functional modules. Several well-performing clustering   algorithms exist to infer topological network partitions. However, due   to respective technical idiosyncrasies they might produce dissimilar   modular decompositions of a given network. In this contribution, we   aimed to analyze how alternative modular descriptions could condition   the outcome of follow-up network biology analysis.        Methodology      We   considered a human protein interaction network and two paradigmatic   cluster recognition algorithms, namely: the Clauset-Newman-Moore and the   infomap procedures. We analyzed to what extent both   methodologies yielded different results in terms of granularity and   biological congruency. In addition, taking into account Guimera?s   cartographic role characterization of network nodes, we explored how the   adoption of a given clustering methodology impinged on the ability to   highlight relevant network meso-scale connectivity patterns.        Results      As   a case study we considered a set of aging related proteins and showed   that only the high-resolution modular description provided by infomap,   could unveil statistically significant associations between them and   inter\/intra modular cartographic features. Besides reporting novel   biological insights that could be gained from the discovered   associations, our contribution warns against possible technical concerns   that might affect the tools used to mine for interaction patterns in   network biology studies. In particular our results suggested that   sub-optimal partitions from the strict point of view of their modularity   levels might still be worth being analyzed when meso-scale features   were to be explored in connection with external source of biological   knowledge.  ","palabras_clave":"protein interaction networks|clustering algorithms|network cartography"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26830,"idioma_id":5,"titulo":"Historia ambiental de los lagos someros de la llanura pampeana desde el Holoceno medio. Inferencias paleoclimáticas","resumen":"En este trabajo se presenta un estudio paleolimnológico basado en el análisis de múltiples indicadores en múltiples sitios con el objetivo de reconstruir la historia evolutiva de cinco lagos someros de la llanura Pampeana desde el Holoceno medio, y así realizar inferencias paleoclimáticas para esta región. Los cinco lagos estudiados respondieron sincrónicamente y mostraron el mismo patrón de evolución paleoambiental durante el Holoceno medio y tardío. Entre los ca. 7000 y 700-500 años cal AP, se evidencia una primera fase clara, dominada por carofitas del género Chara, que cambia a los ca. 700-500 años cal AP hacia una fase turbia dominada por fitoplancton y con una importante presencia de sumergidas del grupo de las angiospermas, que indican fases claras que alternan con el estado turbio general. En la vegetación circundante, se evidencia un cambio desde una comunidad halófita que indica condiciones salobres e inestables hacia la comunidad de macrófitas que caracterizan en la actualidad a estos lagos, que sugiere ambientes con mayor estabilidad. Durante el Holoceno medio y por largos períodos (por ej. ca. 6500 años) la estabilidad del paisaje se mantuvo debido a las condiciones climáticas más secas que las actuales, en las que predominaron fluctuaciones de sequías e inundaciones y\/o condiciones de alta evaporación. Estas fluctuaciones son las que mantuvieron a las comunidades tanto acuáticas como terrestres. A partir de ca. 2000 años cal AP el incremento de la diversidad de macrófitas sumergidas (carofitas y angiospermas) indica el mayor aporte de nutrientes y materia orgánica, causado por un aumento en la intensidad y\/o duración de las precipitaciones. A partir de este momento comienza un cambio gradual que se efectiviza a los ca. 700-500 años cal AP, con el establecimiento de las comunidades de macrófitas emergentes, flotantes y sumergidas características de los sistemas actuales.","palabras_clave":"CAMBIOS DE ESTADO|ESTADO CLARO|ESTADO TURBIO|MACROFITAS SUMERGIDAS|CAMBIO CLIMATICO|LLANURA PAMPENA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":26999,"idioma_id":5,"titulo":"Utilización de imágenes ASTER y Landsat para el monitoreo de la concentración de clorofila-a en el embalse Los Molinos, Córdoba, Argentina","resumen":"Remote sensing can be used as a complementary tool in water quality monitoring of aquatic ecosystems. The aim of this study was to develop models to estimate the spatial distribution of chlorophyll-a concentration (Chl-a) in Los Molinos reservoir using Landsat 7 ETM + and ASTER imagery. Los Molinos reservoir (32 º 49 ´S, 64 º 32´ W) is a multipurpose system used as the second source of water supply for Córdoba?s city. Physical, chemical and biological parameters were measured in the water body coinciding with the passage of the satellites by the study area. Using different statistical techniques, satellite information was related to field data obtaining algorithms that best explained the distribution of Chl-a. These models were validated and used to construct maps providing spatially rich information on patterns of water quality throughout the reservoir. Both sensors could be used for Chl-a monitoring. ASTER sensor, with higher spatial resolution that ETM+, showed a better relationship between observed versus estimated Chl-a data allowing a better discrimination of the spatial variation of the analysed parameter. The generated models can provide a basis for planning future water quality monitoring in different water bodies.","palabras_clave":"EMBALSE    |SENSORAMIENTO REMOTO|CONCENTRACION DE CLOROFILA-A|LANDSAT |ASTER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":27076,"idioma_id":5,"titulo":"La experiencia del crédito solidario en la Argentina","resumen":"El cooperativismo de crédito se desarrolla en la Argentina contemporáneamente con el europeo. En una primera etapa, se caracteriza por un funcionamiento cuasi mutual, vinculado mayoritariamente a instituciones de la colectividad judía. Durante el peronismo histórico se dinamiza su desarrollo y el&nbsp; potencial económico y financiero de las cooperativas rompe con los estrechos moldes de grupo, gremio y actividad, incorporando miles de asociados provenientes de las capas medias y populares, urbanas y rurales. A partir de 1958, la creación del Instituto Movilizador de Fondos Cooperativos como cooperativa de segundo grado provoca una explosión en el número y dispersión geográfica de las entidades y el desarrollo de una nueva operatoria basada en la captación de recursos a través de cuentas a la vista y la existencia de una cámara compensatoria nacional. El crecimiento del cooperativismo en un sector tan sensible como el financiero provoca la temprana oposición de la banca y de la gran burguesía que encuentran aliados en los gobiernos de facto, primero, y en las políticas neoliberales de la década del ´90, después, que implementan medidas altamente restrictivas. Sin embargo, el cooperativismo de crédito no claudica y adecuándose a la normativa, se reorganiza en banca cooperativa y en los últimos años a partir de la reaparición de las cajas de crédito cooperativo.","palabras_clave":"ARGENTINA|COOPERATIVISMO DE CREDITO|CAJAS DE AHORRO|ECONOMIA SOCIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":27087,"idioma_id":5,"titulo":"Crónica. Curso Internacional del Centro de Estudios Latinos","resumen":"CRÓNICA. CURSO INTERNACIONAL CEL.  Las ideas geográficas y la imagen del mundo en la literatura española medieval: las fuentes latinas y su proyección en la literatura de la Edad Media española.   La Plata, Universidad Nacional de La Plata, 5 y 6 de junio de 2012","palabras_clave":"CRONICA|CURSO|CEL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":27225,"idioma_id":5,"titulo":"Multiplicación In Vitro de Myrocarpus Frondosus Allemão (Incienso) a Partir del Establecimiento de Semillas","resumen":"Myrocarpus frondosus Allemão ?incienso? es una especie leñosa con aptitudes maderables, la tala selectiva y la reducción de la superficie boscosa ha llevado a su disminución y consecuente pérdida de variabilidad genética. La propagación in vitro es una herramienta para la conservación de germoplasma y la propagación de árboles selectos. El presente trabajo tuvo como objetivo desarrollar la fase de establecimiento y multiplicación in vitro de M. frondosus. Se ensayaron tratamientos de desinfección en semillas para su establecimiento utilizando, hipoclorito de sodio en distintas concentraciones y tiempo de exposición. En la multiplicación de ápices y segmentos nodales de plántulas in vitro se estudiaron diferentes concentraciones de 6-Bencilaminopurina (6-BAP, 0,1; 0,25; 0,5 y 1 mg\/L) y ácido naftalenacético (ANA, 0,1 mg\/L). Se obtuvo en el establecimiento de semillas un 6,5% de germinación al tratarlas con solución de hipoclorito de sodio al 3%. La mejor respuesta en la multiplicación se logró con la concentración ensayada de 1 mg\/L de 6-BAP y 0,1 mg\/L de ANA.","palabras_clave":"Micropropagación|Fabaceae"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":27268,"idioma_id":5,"titulo":"Reclutamiento y movilización electoral en la Argentina decimonónica. Experiencias políticas en la ciudad y la campaña de Córdoba (1877-1880).","resumen":"¿Cómo se organizaban el reclutamiento y la movilización electoral en las provincias argentinas decimonónicas? ¿Qué diferencias existían entre la dinámica urbana y la rural? ¿Cuál eran las relaciones entre líderes partidarios, dirigentes intermedios y votantes? Este trabajo ensaya algunas respuestas a estos interrogantes a partir del análisis de la política de Córdoba a fines de los años setenta. Para ello aborda dos elecciones particularmente disputadas del periodo y explora fuentes judiciales, actas y padrones electorales, intervenciones periodísticas e intercambios epistolares para iluminar las características de los protagonistas y las experiencias asociadas a esa movilización.","palabras_clave":"Córdoba|Elecciones|Movilización|Reclutamiento"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":27331,"idioma_id":4,"titulo":"Characterization of B-glucosidase produced by the white rot fungus Flammulina velutipes","resumen":"&#946;-Glucosidase production by the white rot fungus Flammulina velutipes CFK 3111 was evaluated using different carbon and nitrogen sources under submerged fermentation. Maximal extracellular enzyme production was 1.6 U\/ml, corresponding to a culture grown in sucrose 40 g\/l and asparagine 10 g\/l. High production yield was also obtained with glucose 10 g\/l and asparagine 4 g\/l medium (0.5 U\/ml). Parameters affecting the enzyme activity were studied using p-nitrophenyl-&#946;-D-glucopyranoside as the substrate. Optimal activity was found at 50°C and pHs 5.0 to 6.0. Under these conditions, &#946;-glucosidase retained 25% of itsinitial activity after 12 h of incubation and exhibited a half-life of 5 h. The addition of MgCl2,urea, and ethanol enhanced the &#946;-glucosidase activity up to 47%, whereas FeCl2, CuSO4, Cd(NO3)2, and cetyltrimethylammonium bromide inflicted a strong inhibitory effect. Glucose and cellobiose also showed an inhibitory effect on the &#946;-glucosidase activity in a concentration-dependent manner. The enzyme had an estimated molecular mass of 75 kDa. To the best of our knowledge, F. velutipes CFK 3111 &#946;-glucosidase production is amongst thehighest reported to date, in a basidiomycetous fungus.","palabras_clave":"B-glucosidase|Flammulina velutipes |submerged fermentation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":27660,"idioma_id":4,"titulo":"Immune response elicited by the oral administration of an intermediate strain of IBDV in chickens","resumen":"The immune response elicited by the oral inoculation of an intermediate strain of infectious bursaldisease virus was studied in chickens. A strong over expression of IL-6, IL-8, IFN and IFN was observedin bursa at 3 days post inoculation together with an increase in splenic NO2 release. An influxof T-lymphocytes was also detected.","palabras_clave":"Immune response|IBDV|chickens"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":27954,"idioma_id":5,"titulo":"Revista Estudios de Filosofía Práctica e Historia de las Ideas","resumen":"En la teoría etnológica y política contemporánea, la conceptualización de las acciones de adscriptos étnicos en términos de acciones orientadas por intereses constituye el núcleo conceptual de la definición  de lo político. Comunalizaciones,   movimientos culturales,  democracia plural radical,  reivindicaciones de derechos colectivos diferenciados,  son todas ellas nociones que refieren a acciones colectivas y a la producción de identidades sobre la base de orientaciones culturales o ethos comunes en el ámbito de la esfera pública. La interpretación de tales expresiones como formas institucionalizadas y públicas de acción colectiva se funda en un concepto de vida política como ?vida común?, como ?acción colectiva pública?,   La siguiente presentación se propone interrogar los márgenes categoriales sobre los que se construye y fundamenta la teoría etnopolítica contemporánea, analizando las nociones de ?común? que ponen en circulación como así también la tensión entre universalismo y particularismo que  hacen emerger","palabras_clave":"ETNOPOLITICA|COMUN|DOMINIO DE SABER|INDIGENAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":27955,"idioma_id":5,"titulo":"Comentario al libro de Intelectuales indígenas en Ecuador, Bolivia y Chile. Diferencia, colonialismo y anticolonialismo","resumen":"En el marco de las variadas formas de manifestación cultural y política que asume el creciente protagonismo de los movimientos indígenas en la escena latinoamericana desde los años ochenta, el libro Intelectuales indígenas en Ecuador, Bolivia y Chile. Diferencia, colonialismo y anticolonialismo de Claudia Zapata Silva se centra en la producción  de un tipo específico de discursividad, aquel situado en el campo de la escritura. Así, se refiere a los ?intelectuales indígenas? como forma emergente de agencia social emancipatoria a la vez que autor  de un tipo particular de escritura producto de su formación disciplinaria en instituciones de educación superior.","palabras_clave":"INTELECTUALES INDÍGENAS|LATINOMAERICA|COLONIALISMO|LITERATURA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":28025,"idioma_id":5,"titulo":"La creación de la Ciudad Universitaria de Buenos Aires (1958-1966): la proyección de una ecología común para la transformación de la vida académica en la Facultad de Ciencias Exactas y Naturales","resumen":"La fase histórica abierta en la Universidad de Buenos Aires (UBA) entre 1957 y 1966, con especial epicentro en la Facultad de Ciencias, Exactas y Naturales (FCEN), fue valorada por muchos en términos de un período de reconstrucción y modernización académica y científica debido a los cambios generados en su seno: los proyectos de reorganización departamental, la extensión del full time, los debates sobre el gobierno y el estatuto, el proyecto de difusión cultural lanzado por EUDEBA, y la creación de la ciudad universitaria (CU en adelante).  Del conjunto de estas transformaciones, impulsadas por Risieri Frondizi como rector normalizador y luego elegido por la Asamblea Universitaria, y por Rolando García, decano de la FCEN, este trabajo analiza la creación de la CU y su relación con los principales elementos que estuvieron detrás de la proyección de una ?universidad de investigación. Visualizada como una de las condiciones de posibilidad para legitimar la integralidad de la enseñanza y la investigación de tiempo completo, la construcción de la CU revivió viejas ideas, discusiones y proyectos (al tiempo que impulsó nuevos) sobre la relación de interdependencia entre el tipo de espacialidad y el desarrollo de determinadas relaciones y prácticas en el ámbito de la investigación y de la enseñanza científicas.","palabras_clave":"UNIVERSIDAD DE BUENOS AIRES|CIUDAD UNIVERSITARIA|FACULTAD DE CIENCIAS EXACTAS Y NATURALES|ARQUITECTURA CIENTIFICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":28754,"idioma_id":5,"titulo":"Magnetoestratigrafía y parámetros magnéticos en los acantilados de la costa bonaerense","resumen":"RESUMENMediante técnicas paleomagnéticas y de magnetismo de rocas se estudian 6 perfiles ubicados en losacantilados costeros entre la localidad de Chapadmalal y el sur de Necochea. Se trata de sedimentosprincipalmente de origen fluvial, aunque también hay depósitos eólicos (loessoides). Se reconocen faciesdepositacionales de diferentes texturas, aunque predominan las facies areno-limosas y limo-arenosas.Las facies post-depositacionales, están representadas por paleosuelos y calcretas, que en algunos casosconstituyen paleosuperficies de extensión regional. Estos sedimentos contienen minerales portadores deremanencia magnética (titano-magnetitas), que permiten registrar cambios de polaridad. Los estudiospaleomagnéticos permitieron definir la presencia de sedimentos de polaridad normal, reversa y ecuatorial.Las zonas de magnetopolaridad fueron asignadas a los crones Brunhes (< 0,78Ma), Matuyama (2,6 a0,78Ma) y Gauss superior (2,9 a 2,6 Ma) en los perfiles de mayor potencia ubicados al este de Miramar.Estos resultados han permitido acotar la edad de estos sedimentos entre el Plioceno tardío y el Holoceno,siendo el Pleistoceno la época más representada en estos acantilados. En los alrededores de Necochea,también se determinaron cambios de polaridad en los perfiles de Bahía de Los Vientos y Punta Negra,mientras que en Balneario Los Ángeles toda la sucesión es de polaridad normal. El análisis de losparámetros magnéticos indica una mayor concentración de titano-magnetitas en la fracción limo grueso.Los bajos valores de &#967;df (< 5 %), indican el escaso o nulo aporte de la fracción super-paramagnética enla mayoría de estos depósitos.Palabras clave: Buenos Aires, Cenozoico tardío, Magnetoestratigrafía, Parámetros magnéticos.","palabras_clave":"MAGNETOESTRATIGRAFÍA|PARÁMETROS MAGNÉTICOS|CENOZOICO TARDÍO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":28941,"idioma_id":5,"titulo":"Columnar Water Vapor Estimation Over Land Using Radiometer Data From SAC-D\/Aquarius. ARGENCON2014-edición especial","resumen":"This paper describes the methodology used for the  calibration of the microwave radiometer MWR of the satellite  SACD\/Aquarius to obtain measurements of integrated water  vapor (IPWV) over the earth.  The results of this work shows that it is possible calibrate  this instrument over earth surface using meteorological and  radiosonde data from station over earth.  Using a model of multiregression the IPWV measurements  are obtained with an error less than 7mm over stations in the  southeast North America.  These results are similar to instruments such as the Advanced  Microwave Scanning Radiometer (AMSR-E) from  NASA, which from algorithms applied to the brightness temperature  measurements allow obtaining IPWV in Geographical  bounded areas.  This work represents an important contribution, using the  data from the radiometer MWR SACD-Aquarius, to provide  measurements of IPWV over land, this data is not currently  available on this instrument.","palabras_clave":"CWV|Satellite radiometer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29142,"idioma_id":5,"titulo":"Presentación de Dossier. Ambiente y Sociedad: Recursos naturales, legislación y conflictos sociales en América Latina, siglos XX y XXI","resumen":"El presente dossier está dedicado a abordar los vínculos sociedad-ambiente enperspectiva histórica a través de estudios regionales. Si bien la Historia Ambiental, como saber histórico, cuenta con más de tres décadas de trayectoria, aún en la actualidad continúa siendo un campo que presenta numerosas aristas por trabajar.Los tres artículos reunidos en el dossier muestran diversidad con relación al origen delas autoras, las regiones que estudian, las fuentes que utilizan y los campos disciplinaresdentro de las que se enmarcan. Una mexicana y tres riojanas examinan prensa, archivos,entrevistas y marcos normativos que presentan un panorama variado del desarrollo de lasrelaciones sociedad-ambiente en perspectiva histórica. Con la publicación de estos textos,se habilita la reflexión crítica y teórica sobre la relación que construye el hombre con el medio natural, puesto que todas las sociedades producen y elaboran una representaciónrespecto al ambiente e instituyen un vínculo particular con la naturaleza.De esta forma, tanto la multiplicidad de enfoques como la diversidad de disciplinas,forman las bases de este espacio aún en construcción que, asimismo, procura explicar latrama de relaciones sociedad-ambiente, donde la naturaleza es entendida como un agentehistórico activo afectado por las relaciones sociales de producción.","palabras_clave":"HISTORIA|AMBIENTE|LATINOAMERICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29243,"idioma_id":4,"titulo":"Influence of the support on the selective ring opening of methylcyclohexane and decalin catalyzed by Rh-Pd catalysts","resumen":"Rh-Pd catalysts supported on Al2O3, SiO2 and SiO2-Al2O3(SIRAL 40) were studied for methylcyclohexane(MCH) and decalin ring opening reactions. It was found that the Rh\/Pd atomic ratios were similar to thetheoretically expected one and the metal dispersion values varied between 30 and 50%. On bimetallic catalysts supported on Al2O3and SiO2, Pd and Rh were present mainly in the form of monometallic particles,whereas a heterogeneous distribution constituted of large Pd particles and small bimetallic ones wereobserved on SIRAL 40. Total and Bronsted acidities followed the order: SIRAL 40 >> Al2O3> SiO2. Al2O3 supported catalysts were the most suitable for MCH ring opening, while the opening of decalin was favoredby using SiO2-Al2O3 (SIRAL 40). The catalysts supported on SiO2 produced mainly dehydrogenated compounds. The higher total and Bronsted acidities of SIRAL 40 series had a great impact on the opening of bicyclic naphthenes, whereas the metal function of the catalyst and the hydrogenolytic activity of Rh had a major role during MCH reaction. Using bimetallic catalysts in the MCH reaction decreased the formationof cracking and dehydrogenated products, and the selective formation of RO products could be optimizedby tuning the working temperature.","palabras_clave":"Selective ring opening|Rh-Pd Catalysts|Support influence"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29266,"idioma_id":5,"titulo":"Memorias de una práctica política: una aproximación a la militancia de la Juventud Peronista de Bahía Blanca (1966-10976).","resumen":"El presente trabajo se centra en la reconstrucción de las memorias militantes de la generación del setenta en Bahía Blanca, a partir de la mirada que el sujeto generacional aporta en el presente sobre dicho pasado. En este sentido procuraremos puntualizar, desde un enfoque etnográfico, en la relación entre las experiencias de vida cotidianas y la militancia, teniendo en cuenta: los procesos histórico-políticos que la atravesaron, la inserción de la militancia en la vida de un sujeto, la estructura organizacional de la Juventud Peronista y la influencia de las fuerzas armadas a lo largo de todo este proceso.","palabras_clave":"MEMORIA|MILITANCIA|GENERACIÓN|ETNOGRAFÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29297,"idioma_id":5,"titulo":"'Cuando el poder político necesita información': notas sobre el vínculo política y policía en la Argentina reciente","resumen":"Este artículo explora una modalidad de vinculación entre política y policía en Argentina. Siguiendo los aportes de Hélene L´Heuillet y Jean Paul Brodeur partimos de una crítica a las visiones que encuentran que la policía mantiene una relación instrumental con la autoridad gubernamental y sostenemos que, más que un simple medio de la política, es un elemento constitutivo de su estructura. Para ello analizamos el órgano de control político en las policías argentinas, el Departamento de Informaciones Policiales (DIP) y seleccionamos el caso de Santiago del Estero. Reconstruimos los procesos, nacionales y provinciales, que dieron lugar a la formación del DIP en la provincia y, a través de la trayectoria de su principal funcionario, mostramos las articulaciones políticas con el juarismo. La investigación se basó en entrevistas con agentes policiales y dirigentes políticos, en particular del juarismo, documentos internos de la policía y documentos extraídos de los expedientes y sentencias de causas judiciales que investigan el terrorismo de Estado en la provincia, archivos de periódicos locales y nacionales. En última instancia buscaremos demostrar que la policía santiagueña, más que un instrumento de dominación, forma parte de y ha tomado parte en la construcción de un orden político; y que ese modo de vínculo entre política y policía, forjado particularmente en la segunda mitad del siglo XX, ha permanecido pese al pasaje de un régimen autoritario a uno democrático.","palabras_clave":"Poder Político|Policía|Violencia Institucional|Democratización"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29363,"idioma_id":4,"titulo":"Discovery of the first B[e] supergiants in M 31","resumen":"B[e] supergiants (B[e]SGs) are transitional objects in the post-main sequenceevolution of massive stars. The small number of B[e]SGs known so far in theGalaxy and the Magellanic Clouds indicates that this evolutionary phase is short.Nevertheless, the strong aspherical mass-loss occuring during this phase, whichleads to the formation of rings or disk-like structures, and the similarity to possibleprogenitors of SN1987A emphasize the importance of B[e]SGs for the dynamicsof the interstellar medium as well as stellar and galactic chemical evolution.The number of objects and their mass-loss behavior at different metallicities areessential ingredients for accurate predictions from stellar and galactic evolutioncalculations. However, B[e]SGs are not easily identified, as they share many characteristicswith luminous blue variables (LBVs) in their quiescent (hot) phase.We present medium-resolution near-infrared K-band spectra for four stars inM31, which have been assigned a hot LBV (candidate) status. Applying diagnosticsthat were recently developed to distinguish B[e]SGs from hot LBVs,we classify two of the objects as bonafide LBVs; one of them currently in outburst.In addition, we firmly classify the two stars 2MASS J00441709+4119273and 2MASS J00452257+4150346 as the first B[e]SGs in M31 based on strong COband emission detected in their spectra, and infrared colors typical for this classof stars.","palabras_clave":"circumstellar matter| infrared: stars  stars: early-type |stars: massive  supergiants"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29529,"idioma_id":5,"titulo":"Biodiversidad y estudio biotecnológico de levaduras en quesos de cabra procedentes de valles y de la Quebrada de Humahuaca - Jujuy ? Argentina","resumen":"En el presente trabajo se determinó la cantidad, biodiversidad y propiedades tecnológicas de levaduras presentes en quesos frescos de cabra en zonas de Valles y Quebrada de Humahuaca de la provincia de Jujuy. En las muestras (n=30) se aislaron 128 cepas las cuales fueron identificadas y estudiadas en las siguientes propiedades tecnológicas: proteólisis, lipólisis, producción de acetoína, asimilación del citrato y producción de pigmentos marrones. Los recuentos oscilaron entre 5,86 log10 ufc.g-1 a 7,10 log10 ufc.g-1 y las especies aisladas fueron Debaryomyces hansenii, Zygosaccharomyces rouxii, Kluyveromyces lactis, Wickerbamiela domerquiae, .Dekkera bruxellensis, Candida valdiviana, Candida novakii, Dekkera bruxellensis, Candida versatilis, Candida magnoliae, Candida albicans, Pichia anómala, Dekkera anómala, Rodotorula spp. Las cepas de D. hansenii, C. magnoliae, Z. rouxii, C. versatilis y K. lactis tuvieron fuerte actividad proteolítica y lipólitica. Solo una cepa de W. domerquiae tuvo una buena actividad proteolítica. Algunas cepas de K. lactis produjeron acetoína y especies D. bruxellensis y C. versatilis metabolizaron el citrato, hidrolizaron la caseína y tuvieron actividad lipolítica. Es por ello que se puede afirmar que las levaduras juegan un papel importante como cultivos iniciadores en la fabricación de quesos y como un suministro de enzimas útiles en la aceleración del proceso de maduración.","palabras_clave":"LEVADURAS|PROTEOLISIS|LIPOLISIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29619,"idioma_id":4,"titulo":"Foaming performance of aqueous albumin and mullite-albumin systems used in cellular ceramic processing","resumen":"Bovine serum albumin (BSA) solutions (5, 10 and 15 vol.%) and stabilized aqueous mullite (40 vol.%)-BSA (5, 10 and 15 vol.%) suspensions were foamed by mechanical stirring at 2300 rpm. The colloidal and rheological behaviors of suspensions were studied by measuring zeta potential and shear flow properties, respectively. The foaming performance of aqueous systems was evaluated by characterizing the foaming capacity and the foam stability by volume and electrical conductivity measurements. Overrun % was considered as a measure of the foaming capacity, while the variation of this parameter, the foam wetness (&#1060;FW) and the foam density stability (FDS %) with the stand time and the time to half collapse (t1\/2) were evaluated in order to study the stability of foamed systems. Median bubble diameters, bubble size distribution widths and bubble shape factors as a function of time were determined by analyzing images captured by confocal laser-scanning microscopy (CLSM). The results related to the stability of foamed systems were used to evaluate the global destabilization mechanism of these systems, analyzing, in particular, the influence of the solid particles in the protein foam. The obtained results are useful for studying the shaping of cellular mullite green bodies from the thermogelation of foamed aqueous ceramic-protein suspensions.","palabras_clave":"MULLITE PROTEIN SUSPENSIONS|FOAMS|FOAMING CAPACITY|FOAM STABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29623,"idioma_id":4,"titulo":"High-Temperature Elastic Properties of Ceramics in the System MgO-Al2O3- SiO2 Measured by Impulse Excitation","resumen":"Young's moduli of talc-based ceramics from the system MgO-Al2O3-SiO2 are measured for temperatures up to 1000 °C via impulse excitation. It is shown that, after pressing at 50 MPa and firing at 1280 °C, MgO-rich compositions exhibit higher porosity and lower Young's moduli (approximately 20-30 % lower than predicted via micromechanical relations). The Young's moduli of materials with less MgO decrease with temperature, but those of MgO-rich ceramics increase with temperature and exhibit a large hysteresis between heating and cooling. Lower absolute values are mainly due to increased porosity, but the reason for the modulus increase with temperature and the hysteresis is the higher enstatite content in the MgO-rich compositions. For a special composition the Young's moduli are more or less temperature-independent and without significant hysteresis effects, probably due to the low content of enstatite and the high content of sapphirine.","palabras_clave":"CORDIERITE CERAMICS|ELASTIC PROPERTIES|TENSILE MODULUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29777,"idioma_id":4,"titulo":"Prevalence and Trends of markers of Hepatitis B virus, Hepatitis C virus and Human Immunodeficiency virus in Argentine blood donors","resumen":"Background: Transfusion-transmitted infections are a major problem associated with blood transfusion. The aim of this study was to determine prevalence and trends of HBV, HCV and HIV in blood donors in Argentina.Methods: A retrospective study was carried out in blood donors of 27 transfusion centers covering the whole country over a period of eight years (2004-2011). Serologic screening assays for HBsAg, anti-HBc, anti-HCV, and anti-HIV were performed in all centers and nucleic acid amplification testing (NAT) was performed in 2 out of the 27 centers.Results: The 2,595,852 samples tested nationwide from 2004 to 2011 showed that the prevalence of HBsAg decreased from 0.336% to 0.198% (p &lt; 0.0001), that of anti-HBc from 2.391% to 2.007% (p &lt; 0.0001), that of anti-HCV from 0.721% to 0.460%, (p &lt; 0.0001) and that of anti-HIV from 0.208% to 0.200 (p = 0.075). The prevalence of HBV, HCV and HIV wasunevenly distributed among the different regions of the country. Two out of 74,838 screening- negative samples were positive in NAT assays (1 HIV-RNA and 1 HCV-RNA); moreover, HBV-DNA, HCV-RNA and HIV-RNA were detected in 60.29, 24.54 and 66.67% of screening-positive samples of the corresponding assays. As regards donors age, positive HBV-DNA and HCV-RNA donors were significantly older than healthy donors (46.6, 50.5 and 39.5 y respectively, p &lt; 0.001).Conclusions: Argentina has a low prevalence of HBsAg, anti-HCV and anti-HIV in blood donors, with a decreasing trend for HBsAg, anti-HBc and anti-HCV but not for anti-HIV over the last 8 years. The uneven distribution of transfusion-transmitted infections prevalence among the different regions of the country highlights the need to implement regional awareness campaigns and prevention. The discrepancy between samples testing positive for screening assays and negative for NAT assays highlights the problem of blood donors who test repeatedly reactive in screening assays but are not confirmed as positive upon further testing. The uneven distribution of age between healthy donors and NAT-positive donors could be related to changes in risks of these pathogens in the general population and might be attributed to a longer exposure to transmission risk factors in elderly people.","palabras_clave":"HEPATITIS BVIRUS|HEPATITIS C VIRUS|VIRUS DE LA INMUNODEFICIENCIA HUMANA|PREVALENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29859,"idioma_id":4,"titulo":"Determination of amorphous\/rubbery states in freeze-dried prebiotic sugars using a combined approach of near infrared spectroscopy and multivariate analysis","resumen":"Galacto-oligosaccharides (GOS) and lactulose are well-recognized prebiotics widely used in functional food and pharmaceutical products, but there is still a lack of knowledge regarding their physical?chemical properties. In this study, a physical?chemical approach on two GOS of different composition (GOS Cup Oligo H-70® and GOS Biotempo) and lactulose was assessed. Mid infrared and Raman spectra of the freeze-dried sugars allowed their structural characterization in the amorphous state, lactulose, showing the main spectral differences.  Freeze-dried sugars were then equilibrated at 4&nbsp;°C at relative humidity (RH) ranging from 11% to 80%. Near-infrared reflectance spectra were registered in each condition in the 900- to 1700-nm region. A principal component analysis (PCA) was performed on the three sugars equilibrated at different RH. In all the three sugars, the groups observed explained more than 95% of the variance and were related with the RH of the samples. According to the loading plots of PC1, the main differences related with RH were observed in the 1380- to 1500-nm region.  As the amorphous states are very sensitive to changes in temperature and moisture content, and the moisture content is related with the parameter T-Tg (T: storage temperature; Tg: vitreous transition temperature), an effort was made to determine this parameter directly from the NIR spectra. To this aim, a partial least square model (PLS) was defined. Tg values obtained by differential scanning calorimetry (DSC) were used to calculate the T-Tg values of reference. The model was validated with an independent set of data. The mean of predicted values fitted nicely T-Tg obtained from DSC (correlation&nbsp;=&nbsp;0.966; R2&nbsp;=&nbsp;0.934), thus supporting the use of the PLS model to investigate unknown samples.  The stability of amorphous sugars in foods and pharmaceuticals is of practical and economical importance because it affects different quality attributes of foods, including texture, aroma retention and shelf life. Therefore, predicting T-Tg, a parameter that is independent on the sugar investigated, directly from their NIR spectra is of utmost importance to determine the shelf life of food and food-related products and up to our knowledge has never been determined hereto.","palabras_clave":"lactulose|GOS|NIR|Tg"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":29866,"idioma_id":4,"titulo":"Eigenvalue problems in a non-Lipschitz domain","resumen":"In this paper we analyze piecewise linear finite element approximations of certain eigenvalue problem for the Laplace operator in a domain &#937; with an external cusp. Since &#937; is curved and non-Lipschitz the classical spectral theory is properly adapted and using convergence results for the source problem, H^1 quasi optimal order of convergence for the eigenfunctions a double order of convergence for the eigenvalues is obtained in appropriate graded meshes.","palabras_clave":"EIGENVALUES|EXTERNAL CUSPS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30166,"idioma_id":5,"titulo":"Reproduccion de la vida humana. Otro desarrollo posible.","resumen":"Los problemas ambientales tienen un origen complejo, ocasionado en las exigencias propias del capitalismo, donde la misma noción de recurso natural con que se designan los bienes de la naturaleza permite dimensionarlos en términos estrictamente económicos. En la naturalización de estas problemáticas explicamos el cambio ambiental y los desastres naturales como si se debieran simplemente a patrones demográficos, al crecimiento y dispersión de la población. Una de las probabilidades es que el imperativo del crecimiento económico impuesto por la modernidad señale un rumbo incorrecto y en consonancia con las cosmovisiones e identidades locales, en lo que se refiere a la idiosincrasia de los actores y sus necesidades reales","palabras_clave":"Racionalidad |Desarrollo |Ambiente|Consumo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30440,"idioma_id":5,"titulo":"Extracción Automática de Metadatos como Soporte para el Autoarchivo de Objetos Digitales en Repositorios","resumen":"En este trabajo se propone facilitar al usuario el autoarchivo de sus objetos digitales educativos en un repositorio institucional. Para esto, se modifica el flujo de carga estándar de la plataforma DSpace, proponiendo un nuevo flujo para el depósito de objetos de modo que pueda integrarse en este proceso un extractor de metadatos. Se presenta una arquitectura abierta de un módulo extractor automático de algunos metadatos de los documentos. Estos metadatos extraídos automáticamente son luego validados por el usuario en el proceso de descripción del objeto. Para diseñar el extractor se analizaron distintas herramientas de extracción y se optó por la combinación que arrojó mejores resultados. Este módulo se ha diseñado de modo de poder integrar otras herramientas extractoras. Se ha desarrollado un prototipo en JAVA de este asistente y se ha experimentado sobre dos corpus de documentos, uno en idioma Inglés y otro en idioma Español. En este trabajo, se presentan resultados de la extracción automática de los metadatos Palabras clave, Título y Autores, en documentos en ambos idiomas, los cuales resultan promisorios. Mediante este asistente se espera ayudar al usuario en el proceso de carga de objetos digitales educativos disminuyendo así su trabajo, y mejorando la cantidad y la calidad de los metadatos cargados.","palabras_clave":"Extracción automática de metadatos|Objetos Digitales Educativos|Repositorios|Flujo de carga"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30442,"idioma_id":4,"titulo":"Exposure to polycyclic aromatic hydrocarbons in urban environments: Health risk assessment by age groups","resumen":"      A  detailed investigation was conducted into the concentration of polycyclic  aromatic hydrocarbons (PAHs) associated with PM10 particles collected  during 2012 in an urban area in Cordoba, Argentina. Their composition was  studied and the lifetime lung cancer risk resulting from exposure to total and  individual PAHs was estimated. Samples of PM10 were collected daily on  fiber glass filters with PAHs being extracted with methylene chloride and analyzed by HPLC.  Mean PAH concentrations were higher during autumn and winter. In contrast, during  warm months, high ambient temperature and wind speed contributed to a decrease in  the PAH ambient concentrations. The PAH levels found in the present study were within  the range of those reported in other polluted urban areas. However risk factors  calculated for exposure to individual and cumulative PAHs exceeded the carcinogenic  benchmark level of 1x10&#8722;6 early in childhood, implying that these PAH  concentrations represent a serious risk to public health.   ","palabras_clave":"Particulate-phase PAHs|Cordoba|Temperature|Carcinogenic risk|Seasonal variations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30539,"idioma_id":4,"titulo":"A K-band spectral mini-survey of Galactic B[e] stars","resumen":"We present a mini-survey of Galactic B[e] stars mainly under taken with the Large Binocular Telescope (LBT). B[e] stars show morphologicalfeatureswith hydrogenemission lines and and infrared excess, attributed to warm circumstellar dust. In general, these features are&nbsp; assumed to arise from dense, non-spherical, disk-forming circumstellar material in which molecules and dust can condensate. Due to the lack of reliable luminosities, the class of Galactic B[e] stars contains stars at very different stellar evolutionary phases like Herbig AeBe, supergiants or planetary nebulae. We took near-infrared long-slit K-band spectra for a sample of Galactic B[e] stars with the LBT-LuciI. Prominent spectral features, such as the Brackett &#947;line and CO band heads are objects. Among others we find one LBV candidate (MWC314), one supergiant B[e] candidate with 13CO (MWC137) and in two cases (MWC623 and AS381) indications for the existence of a late-type binary companion, complementary to previous studies. For MWC84, IR spectra were taken at different epochs with LBT LuciI and the GNIRS spectrograph at the Gemini North telescope. The new data show the disappearance of the circumstellar CO emission around this star, previously detectable over decades. Also no signs of a recent prominent eruption leading to the formation of new CO disk emission are found during 2010 and 2013.","palabras_clave":"Infrared|Circumstellar matter|B[e] stars"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30585,"idioma_id":4,"titulo":"Fermentation by Lactobacillus paracasei of galactooligosaccharides and low-molecular weight carbohydrates extracted from squash (curcubita maxima) and lupin (lupinus albus) seeds","resumen":"The in vitro prebiotic activity of galactooligosaccharides (GOS) and low-molecular-weight carbohydrates (LMWC) extracted from lupin and squash seeds on the growth of Lactobacillus paracasei BGP1 was studied. To this end, the change in cell density after 24 h of L. paracasei growth on 1% (w\/v) glucose, 1% (w\/v) raffinose, 1% (w\/v) commercial inulin GR, 1% (w\/v) lupin extract, and 1% (w\/v) squash extract relative to the change in cell density of a mixture of enteric strains under the same culture conditions were evaluated. Additionally, the principal components of GOS and LMWC in the extracts were identified using Thin Layer Chromatography. The highest prebiotic activity score was for L. paracasei grown on squash extract (0.55±0.03), followed by lupin extract (0.49±0.02), inulin (0.38±0.05) and raffinose (0.37±0.05). These results will contribute to selecting plant species as potential sources of prebiotic ingredients for the development of functional foods.","palabras_clave":"GALACTOOLIGOSACCHARIDES|LOW-MOLECULAR-WEIGHT CARBOHYDRATES |CURCUBITA MAXIMA|LUPINUS ALBUS|LACTOBACILLUS PARACASEI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30627,"idioma_id":5,"titulo":"Logica de Segundo Orden y el Modelo Estandar de la Aritmetica","resumen":"El propósito de este artículo es defender la tesis según la cual el uso de la lógica de segundo orden es la mejor opción para capturar el modelo estándar de la aritmética.  Esta idea no es novedosa y ha sido sostenida por otros autores, dentro de los que por supuesto se destaca Stewart Shapiro [1991]. En este caso, Shapiro vincula la utilización de recursos de orden superior a la plausibilidad del estructuralismo en matemática. Es bien conocido que desde el punto de vista del estructuralismo, la aritmética es acerca de una única estructura, la estructura estándar de la aritmética. Pero, como consecuencia del Teorema Löwenheim-Skolem, las teorías de primer orden son satisfechas por modelos no estándar que no instancian esta estructura. De esta manera, los defensores del estructuralismo deben dar una explicación acerca de cómo fijar una única estructura singular como la interpretación pretendida de nuestro lenguaje de la aritmética. Y dado el resultado de categoricidad de la aritmética de segundo orden, esa explicación puede ofrecerse adoptando recursos que trasciendan la utilización de lenguajes con cuantificación de primer orden. Sin embargo, diversos argumentos han sido presentados para mostrar que la adopción de tales recursos es inaceptable. Fundamentalmente, porque habría buenos motivos para dudar del carácter lógico de los recursos de orden superior. El objetivo de este trabajo es responder a cada una de esas críticas, intentando brindar indirectamente razones para la adopción de los mencionados recursos como individuadores del modelo estándar de la aritmética. ","palabras_clave":"SECOND ORDER LOGIC|STANDARD MODEL |METALOGIC |CATEGORICITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30786,"idioma_id":5,"titulo":"La crisis de la democracia ateniense a través del teatro trágico","resumen":"Indexación: www.latindex.org - www.annee-philologique.com - www.scielo.org.ar.Resumen: El artículo analiza tres tragedias de finales del siglo V a.C.: Edipo en Colono, Orestes y Bacantes, postulando que el discurso trágico implica un modo de pensamiento de la política democrática. En el marco de la crisis sufrida por Atenas durante ese período, se explora cómo dichas tragedias plantean el problema de la stásis como un aspecto central de la situación política que caracteriza la trama puesta en escena en cada caso. Se asume que las representaciones trágicas del conflicto sedicioso ponen a disposición de la audiencia recursos de pensamiento ligados a la coyuntura en que las obras fueron exhibidas.","palabras_clave":"Atenas|Democracia|Tragedia|Pensamiento"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30804,"idioma_id":5,"titulo":"¿CUÁNTA MÚSICA CABE EN UNA PÁGINA DE PERIÓDICO? SONIDO IMPRESO EN PAPEL A PRINCIPIOS DEL SIGLO XX","resumen":"Artículo que cuenta la historia del fotoliptófono (equipo reproductor y grabador de audio en la década de 1930 inventado en Argentina)","palabras_clave":"Patrimonio cultural|Grabación sonora|Industria discográfica|Tecnología de la comunicación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":30910,"idioma_id":4,"titulo":"Correlation between psychosocial stress, smoking and periodontal status in adults","resumen":"The periodontal diseases are infections associated with pathogenic microorganisms and host response alterations. The psychosocial factors like the stress and inadequate coping behaviours to it may exert immunosuppressive effects, increasing susceptibility to periodontitis. The aim of the observational, cross-sectional study was to research the association between psychosocial stress, coping behaviours and smoking with periodontal condition. One hundred and sixty six voluntary subjects were recruited of both sexes, with healthy systemic conditions, with a mean age of 41, 2 ± 11,3 years, between 25-65 years of age, that go to the Dentistry Branch of National University of Cuyo. Written informed consent was requested. For stress and coping behaviors assessment tests were applicated: Social Readjustment Rating Scale (SRRS) by Holmes &amp; Rahe, Stress Symptom Inventory (SSI) by Lipp &amp; Guevara and coping behaviours questionnaire COPE by Carver. Levels of salivary cortisol were determined by radioimmunoassay and smoking habits were evaluated. The examinations of the periodontal condition were performed by a single examiner: probing pocket depth, attachment level, gingival and plaque index. The statistical survey included: bivariated and multivariated logistic regression, X 2 test; analysis OR CI 95% and ANOVA. The obtained results demonstrate significative association by bivariate analysis: age and periodontal condition (p&lt;0,0001); coping behaviours and periodontal condition&nbsp; (p&lt;0,0001) OR 5,3 CI95% (2,2-12,6); smoking and periodontal condition (p&lt;0,0001) OR 3,36 CI95% (1,6-7,0); cortisol and periodontal condition (p0,0008). Bivariate analysis did not found significant difference between stress and periodontal condition. Multivariated logistic regression analysis adjusted to age found significant association of the relationship periodontal condition with stress (p=0,014), coping behaviors (p0, 030), smoking (p=0,031), age (p&lt;0, 0001). Multifactorial covariance analysis showed significant association of age with clinical parameters (p&lt;0, 0001). The subjects that show stress, inadequate coping behaviours and smoke are more susceptible to the periodontal damage. High levels of salivary cortisol are associated with major periodontal damage. ","palabras_clave":"PERIODONTAL DISEASES|PSYCHOSOCIAL STRESS|COPING BEHAVIORS|SMOKING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31053,"idioma_id":5,"titulo":"Reseña Ciudades Rebeldes: del Derecho a la Ciudad a la Revolución Urbana","resumen":"Geógrafo de inscripción marxista, David Harvey es uno de los máximos exponentes de la geografía radical, desde donde ha realizado contribuciones sustanciales al campo de los estudios urbanos críticos. En Ciudades Rebeldes este autor evidencia con el rigor teórico, metodológico y analítico que caracteriza su vasta producción, las contradicciones del proceso de urbanización en el capitalismo neoliberal.","palabras_clave":"Derecho a la ciudad|Revolución urbana|Harvey"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31234,"idioma_id":5,"titulo":"On Economic Optimality of Model Predictive Control","resumen":"Model Predictive Control (MPC) is the most used advanced control strategy in the industries, mainly due to its capability to fulfill economic objectives, taking into account a dynamic simplified model of the plant, constraints, and stability requirements. In the last years, several economic formulations of MPC have been presented, which get over the standard setpoint-tracking formulation. The goal of this work is to provide, by means of application to a highly nonlinear plant, a comparison of different strategies, focusing mainly on economic optimality, computational burden, and economic performance.","palabras_clave":"Model Predictive Control|Economic Optimality|Real Time Optimization|Economic Performance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31244,"idioma_id":4,"titulo":"Mid-late Holocene Climate and Trophic States in a Shallow Lake From the Southern Pampa Plain, Argentina","resumen":"A decadal-scale multiproxy record of ostracods, granulometric and geochemical data from Lake La Brava, Southeastern Pampas from Argentina, in South America, provides a high-resolution record of climate change spanning the last 4800 years. This record exhibits millennial-scale trends evident in other studies, but with much more detail on short-term climate variability and on the rapidity and timing of certain climatic shifts. We propose an hydroecological model for Lake La Brava, a conceptual framework about how and why this lake has reacted to shift in climate in the long term, which includes lake level, trophic states, in-lake processes and interactions between the lake and the landscape. Cyclic shifts between clear and turbid states occurred since the Early Late Holocene forced by climatic drivers. Turbid regimes predominate during highest lake levels and droughts although the observed changes cannot be related unequivocally to lake level changes, since other factor such as winds can push the system to a different regime. Based on this conceptual framework, we propose that lake level, water column mixing conditions, inflow from aquifer and springs, and human impact are the most important parameters influencing internal lake processes, notably affecting the composition and characteristics of the sediments. Generally humid conditions and high lake level alternating with short term (decadal to centennial) dry episodes prevailed between 4780-4470 cal yr BP and 2010-410 cal yr BP. Relative dry conditions and low lake levels took place between 4450-2020 cal yr BP and 380-150 cal yr BP, the former punctuated by multi-decadal wetter intervals, the latter in coincidence with the Little Ice Age. Human impact started around 50 cal yr BP (1900 AD) probably related to human-induced geomorphic processes. Precipitation variations in the Pampas have been linked to intensification of South Atlantic Cyclone which interrupts the passage of the eastern perturbations and consequently decreases moisture advection over the region, and intensification of the southern Pacific anticyclone and a weakening of the Atlantic anticyclone that induces east-southeast anomalous flow and consequently increases moisture advection over the region.","palabras_clave":"HOLOCENE|SHALLOW LAKES|PAMPA PLAIN|TROPHIC STATES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31462,"idioma_id":4,"titulo":"Inhibition of Aminoglycoside 6'-N-Acetyltransferase Type Ib by Zinc: Reversal of Amikacin Resistance in Acinetobacter baumannii and Escherichia coli by a Zinc Ionophore.","resumen":"In vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6?)-Ib] was inhibited by ZnCl2 with an IC50 of 15 &#956;M. Growth of Acinetobacter baumannii or Escherichia coli harboring aac(6?)-Ib in cultures containing 8 &#956;g\/ml amikacin was significantly inhibited by addition of 2 &#956;M Zn2+ in complex with the ionophore pyrithione (ZnPT).","palabras_clave":"Inhibition|Zn|antibiotic resistance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31556,"idioma_id":5,"titulo":"Comunicacion estratégica: Indicadores comunicacionales en dimensiones multiples.","resumen":"Este proyecto se propone investigar la dimensión comunicacional en organizaciones de diversos ámbitos en Argentina desde la metaperspectiva teórica y metodológica de la comunicación estratégica como un aporte al diseño y la implementación de las acciones comunicacionales integradas a procesos de cambio social conversacional. En tal sentido, el trabajo desarrolla herramientas para la construcción, selección, relevamiento y registro de indicadores en distintas dimensiones comunicacionales que permitan un monitoreo continuo de actividades, procesos y productos de comunicación en el marco de proyectos de desarrollo en programas, organizaciones y empresas.","palabras_clave":"COMUNICACION|ESTRATEGIAS|METODOLOGÍA|DIMENSIONES DE LA COMUNICACIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31599,"idioma_id":5,"titulo":"Grutas, rocallas y arboles de cemento: otra arquitectura desaparecida de Buenos Aires 1880-1910","resumen":"El artículo analiza cómo una arquitectura que fue el estilo oficial del estado entre 1880 y principios de siglo XX, que definió el paisaje de todas las plazas, parques y jardines de Buenos Aires, fue borrada y silenciada a los pocos años al punto de quedar prácticamente olvidada en la memoria de la ciudad. Se analiza el caso de las dos principales grutas que había en la ciudad: Recoleta y Constitución, por la escala que llegaron a alcanzar y lo increíble que resulta imaginar su arquitectura en la ciudad actual.","palabras_clave":"BUENOS AIRES|ROCALLAS|ARQUITECTURA|HETEROTOPIAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31707,"idioma_id":5,"titulo":"El acceso a la tierra entre los indios amigos de la frontera bonaerense, 1850-1880","resumen":"En este trabajo intentamos reunir la información disponible sobre estos casos, apuntando a realizar una primera aproximación a estos procesos de negociación indígena por la propiedad de las tierras. Buscaremos identificar la variedad de contextos desde los que surgieron estas solicitudes indígenas, las motivaciones y expectativas de quienes las llevaron adelante, los recursos y medios empleados para gestionarlas así como los cambios generados en las relaciones tribales a partir de la obtención de los títulos. Ello nos dará pie a un breve ejercicio comparativo que apunta a evaluar la importancia de los espacios locales y de las tramas de poder tejidas en los mismos en el curso que asume la inserción de los indios amigos por sobre las políticas gubernamentales a ellos dirigidas: seguiremos así las trayectorias de la Tribu de Coliqueo en 9 de Julio-Gral. Viamonte, la de la Tribu de los Rondeau en 25 de Mayo y la de los Catrieleros y Tapalqueneros en Azul y Tapalqué.","palabras_clave":"INDIOS AMIGOS|FRONTERA BONAERENSE|TIERRAS|PROPIEDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31777,"idioma_id":5,"titulo":"Modifi caciones de la estructura ósea del fémur proximal.","resumen":"Objetivo: Los análisis de osteoporosis en restos óseos cobran relevancia en tanto permiten evaluar el estado de salud ósea de una población. Una de las regiones óseas utilizadas para la estimaciónde la pérdida de la densidad mineral ósea es la epífi sis proximal del fémur. El objetivo del trabajo fue analizar, a partir de restos esqueletarios, la variación de la estructura ósea delfémur proximal en adultos y estudiar su relación con la masa corporal, sexo y edad.del trabajo fue analizar, a partir de restos esqueletarios, la variación de la estructura ósea delfémur proximal en adultos y estudiar su relación con la masa corporal, sexo y edad.el estado de salud ósea de una población. Una de las regiones óseas utilizadas para la estimaciónde la pérdida de la densidad mineral ósea es la epífi sis proximal del fémur. El objetivo del trabajo fue analizar, a partir de restos esqueletarios, la variación de la estructura ósea delfémur proximal en adultos y estudiar su relación con la masa corporal, sexo y edad.del trabajo fue analizar, a partir de restos esqueletarios, la variación de la estructura ósea delfémur proximal en adultos y estudiar su relación con la masa corporal, sexo y edad.Los análisis de osteoporosis en restos óseos cobran relevancia en tanto permiten evaluar el estado de salud ósea de una población. Una de las regiones óseas utilizadas para la estimaciónde la pérdida de la densidad mineral ósea es la epífi sis proximal del fémur. El objetivo del trabajo fue analizar, a partir de restos esqueletarios, la variación de la estructura ósea delfémur proximal en adultos y estudiar su relación con la masa corporal, sexo y edad.del trabajo fue analizar, a partir de restos esqueletarios, la variación de la estructura ósea delfémur proximal en adultos y estudiar su relación con la masa corporal, sexo y edad.fi sis proximal del fémur. El objetivo del trabajo fue analizar, a partir de restos esqueletarios, la variación de la estructura ósea delfémur proximal en adultos y estudiar su relación con la masa corporal, sexo y edad.Materiales y métodos: Se tomó una muestra de 30 fémures izquierdos pertenecientes a la colección osteológica «Prof. Dr. Rómulo Lambre» de la Facultad de Ciencias Médicas (UniversidadNacional de La Plata), y se estimaron 2 índices radiológicos, el índice córtico metafi sario y el índice trabecular. Posteriormente, se estudió la relación entre los valores obtenidos y la masacorporal, el sexo y la edad de los individuos.índice trabecular. Posteriormente, se estudió la relación entre los valores obtenidos y la masacorporal, el sexo y la edad de los individuos.osteológica «Prof. Dr. Rómulo Lambre» de la Facultad de Ciencias Médicas (UniversidadNacional de La Plata), y se estimaron 2 índices radiológicos, el índice córtico metafi sario y el índice trabecular. Posteriormente, se estudió la relación entre los valores obtenidos y la masacorporal, el sexo y la edad de los individuos.índice trabecular. Posteriormente, se estudió la relación entre los valores obtenidos y la masacorporal, el sexo y la edad de los individuos.étodos: Se tomó una muestra de 30 fémures izquierdos pertenecientes a la colección osteológica «Prof. Dr. Rómulo Lambre» de la Facultad de Ciencias Médicas (UniversidadNacional de La Plata), y se estimaron 2 índices radiológicos, el índice córtico metafi sario y el índice trabecular. Posteriormente, se estudió la relación entre los valores obtenidos y la masacorporal, el sexo y la edad de los individuos.índice trabecular. Posteriormente, se estudió la relación entre los valores obtenidos y la masacorporal, el sexo y la edad de los individuos.fi sario y el índice trabecular. Posteriormente, se estudió la relación entre los valores obtenidos y la masacorporal, el sexo y la edad de los individuos.Resultados: El valor promedio estimado por el índice córtico metafi sario señaló una baja calidad ósea, sin diferencias entre sexos, y no presentó correlaciones con la edad ni con el peso de losindividuos. El 50% de los fémures presentó un valor de índice trabecular indicativo de osteoporosis,sin una diferencia signifi cativa entre sexos.ósea, sin diferencias entre sexos, y no presentó correlaciones con la edad ni con el peso de losindividuos. El 50% de los fémures presentó un valor de índice trabecular indicativo de osteoporosis,sin una diferencia signifi cativa entre sexos.El valor promedio estimado por el índice córtico metafi sario señaló una baja calidad ósea, sin diferencias entre sexos, y no presentó correlaciones con la edad ni con el peso de losindividuos. El 50% de los fémures presentó un valor de índice trabecular indicativo de osteoporosis,sin una diferencia signifi cativa entre sexos.fi cativa entre sexos. Conclusión: La baja calidad ósea del material se ajustó a lo esperado, debido a la edad de los sujetos analizados. Esto puede haber interferido en la visibilidad de otros procesos, ocurridos envida, que podrían haber sido causantes de la pérdida de densidad mineral ósea.sujetos analizados. Esto puede haber interferido en la visibilidad de otros procesos, ocurridos envida, que podrían haber sido causantes de la pérdida de densidad mineral ósea.La baja calidad ósea del material se ajustó a lo esperado, debido a la edad de los sujetos analizados. Esto puede haber interferido en la visibilidad de otros procesos, ocurridos envida, que podrían haber sido causantes de la pérdida de densidad mineral ósea.","palabras_clave":"Fémur|Osteoporosis;|Índice córtico|metafi sario;|Índice trabecular"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":31795,"idioma_id":5,"titulo":"IBERTIC: una iniciativa de autoevaluación de proyectos de incorporación de TIC","resumen":"El artículo que nos ocupa presenta una iniciativa que busca  facilitar la autoevaluación y el monitoreo de los proyectos de incorporación  de tic en educación por parte de los propios responsables de su diseño  (docentes, directores, supervisores). A tal fin, fue diseñado un sitio web en  el cual se ponen a disposición los siguientes materiales: a) una selección  de documentos y bibliografía vinculados a la evaluación de proyectos tic;  b) guías y orientaciones metodológicas, y c) instrumentos para la autoevaluación  de los proyectos tic (encuestas, pautas para entrevistas y pautas  para grupos focales, entre otros). A su vez, el desarrollo contempla un  diagnóstico que cada institución puede realizar inicialmente y recuperar  con posterioridad para reflexionar acerca del grado de avance alcanzado","palabras_clave":"autoevaluación|proyectos tic|monitoreo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":32133,"idioma_id":5,"titulo":"Lo rural y lo científico: La presencia de la Estación Experimental Regional Agropecuaria (EERA) INTA Bariloche 1962- 1968","resumen":"En este trabajo se discute el modo en que desde una práctica científica se toma lo rural en la estepa norpatagónica durante la segunda mitad del siglo XX, observando la intervención de estudios científicos asociados a la explotación ovina. Se revisa el rol del INTA y la particular ubicación del Centro Regional en Bariloche. Como resultado destacamos la vinculación de la elección de la locación con la red tecno-científica que se desplegaba en el país, antes que con las necesidades puntuales del espacio rural aledaño. Esto redundó en el sostenimiento de desigualdades sociales en el modelo productivo, afianzado por la incorporación tecnológica que se resuelve desde la agencia científica.","palabras_clave":"Ciencia|Políticas Desarrollistas|Ovinización|INTA Bariloche"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":32165,"idioma_id":4,"titulo":"Baseline defense system of commercial male king crab Lithodes santolla from the Beagle Channel","resumen":"Environmental and physiological variations influence the steady-state concentration of free oxygen radicals in cells. Because of the seasonal life cycle of Lithodes santolla in the Beagle Channel, a baseline study of the antioxi- dant physiological variations along the seasons is necessary for a better understanding of its ecophysiology. The aimof this study was to evaluate the seasonal variations in gills, hemolymph,muscle and hepatopancreas of the: i) enzymatic activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione transferase; ii) ascorbic acid and total glutathione; iii) lipid peroxidation and protein oxidation; iv) glucose, proteins and pH. Seasonality found in the antioxidant defense system of L. santolla from the Beagle Channel acts in a collabo- rativeway during themost relevant life cycle phases (reproduction andmolting), avoiding a long termoxidative stress. The antioxidant systemalso shows changes in the enzymatic activities likely caused by the environmental factors, such as low temperatures during winter and spring seasons","palabras_clave":"ANTIOXIDANT|BIOMARKER|DECAPOD|REACTIVE OXYGEN SPECIES|SEASONAL |SUB-ANTARCTIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":32703,"idioma_id":5,"titulo":"La presencia de artefactos arqueomalacologicos en la localidad arqueológica Delta del Arroyo Vulcana (lago Musters, Provincia del Chubut)","resumen":"En este trabajo se presenta un análisis morfotecnológico realizado a varios artefactos arqueomalacológicos recuperados en la localidad arqueológica Delta del arroyo Vulcana, ubicada en la margen noroeste del lago Musters (Provincia del Chubut). Se recuperaron ?tanto en estratigrafía como en superficie- cuentas de collar, instrumentos y artefactos indeterminados. Algunas piezas pudieron ser identificadas, correspondiendo a gasterópodos marinos de la familia Volutidae procedente del océano Atlántico, mientras que las restantes piezas debido a su grado de alteración tafonómica y modificación antrópica no se pudo determinar sobre valvas de qué especies habían sido manufacturadas. Dado el estado del conocimiento de los artefactos arqueomalacológicos en la Patagonia, el estudio de este tipo de restos aporta al conocimiento general del rol de los mismos para las poblaciones patagónicas. En este sentido los resultados son contextualizados y discutidos en relación a la movilidad, el intercambio y la existencia de redes de intercambio que abarcaban la costa y el interior. ","palabras_clave":"LAGO MUSTERS|ARQUEOMALACOLÓGICO|CUENTAS DE COLLAR|PATAGONIA CENTRAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":32735,"idioma_id":4,"titulo":"Stress in wild Greater Rhea populations: effects of agricultural activities on seasonal excreted glucocorticoid metabolite levels.","resumen":"In recent years, wild populations of Greater Rhea (Rhea americana) have declineddrastically, due mainly to the conversion of grassland into cropland as a result ofintensive, specialized agricultural practices. In this study we test the potential stressfuleffects of agricultural activities on this ratite by assessing their adrenocortical response.Specifically, we compared fecal glucocorticoid metabolite (FGM) levels of rheas livingin two areas under very different land use: grasslands mainly used for cattle grazingand agro-ecosystems intensively used for crop production. Groups of rheas wereobserved during 45 to 50 min from a distance of approximately 1 km to avoid anypotential disturbance. Therefore, no matching of each fecal sample with a particularsex or individual within the group was possible. Radioimmunoassay of fecal samplesfrom 269 individuals indicated no significant differences in mean concentrations ofFGM from the two habitats sampled.. In the agro-ecosystem we found no overall effectof agricultural practices on the bird´s FGM levels. However, during the dry season FGMconcentrations were significantly higher, which may represent a stress response to thelow availability of food in the post-harvesting season. In contrast, no increase in theFGM levels was registered during the dry season in the grassland, where food wasavailable throughout the year. In this environment the highest increases in FGM levelscoincided with the reproductive period, likely due to the frequent agonist encountersbetween males at this time of the year. Our findings therefore suggest that theagricultural practices have to be viewed as chronic environmental stressors for GreaterRhea populations living under such conditions. The present results support earlierresearch showing detrimental impacts of agricultural activities on this species, whichinhabits the most productive regions of South America.","palabras_clave":"field endocrinology|Greater Rhea|human disturbance|stress|fecal glucocorticoid metabolites|agricultural practices"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":32816,"idioma_id":4,"titulo":"Photonic and Quantum Efficiencies for the Homogeneous Photo-Fenton Degradation of Herbicide 2,4-D using Different Iron Complexes","resumen":"BACKGROUND: An experimental study of the homogeneous photo-Fenton degradation of herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is presented.Different sources of iron in water solution were studied: sulphate, oxalate and citrate complexes. The performances of these complexes were evaluated by means of two parameters: (i) the photonic efficiencies of degradation and mineralization; and (ii) the quantum efficiencies of degradation and mineralization. Moreover, in order to quantify the consumption of the oxidizing agent, two parameters were also defined and evaluated: the initial specific consumption of the hydrogen peroxide and the minimum hydrogen peroxide consumption for complete mineralization.  RESULTS: For pH=5 and T =35 C, the degradation photonic efficiency using ferric sulphate was 6 times lower than that obtained with the ferric citrate. On the contrary, at pH=5, quantum efficiencies of mineralization close to 50% for citrate and oxalate complexes were attained. For pH=5 and 25 or 35 C, the initial specific consumption of hydrogen peroxide for the ferric sulphate was 5 times higher than those of the remaining complexes. However, considering all the operating conditions, the minimum hydrogen peroxide consumption for complete mineralization using the oxalate complex was always lower than or at most similar to those observed in the other two complexes.  CONCLUSION: Using different sources of iron, the influence of pH and temperature on the pollutant degradation and mineralization process was determined. For pH=5 and both temperatures, the ferric sulphate system required more than twice the time to achieve complete degradation of the herbicide. Moreover, mineralization only reached 55% after 180 min operation.","palabras_clave":"Photo-Fenton|Solar energy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":32827,"idioma_id":4,"titulo":"Antiapoptotic factor Humanin is expressed in normal and tumoral pituitary cells and protects them from TNFalpha-induced apoptosis","resumen":"Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has antiapoptotic action. In the present work, we demonstrated by immunocytochemical analysis and flow cytometry the expression of HNr in the anterior pituitary of female and male adult rats as well as in pituitary tumor GH3 cells. HNr was localized in lactotropes and somatotropes. The expression of HNr was lower in females than in males, and was inhibited by estrogens in pituitary cells from both ovariectomized female and orquidectomized male rats. However, the expression of HNr in pituitary tumor cells was not regulated by estrogens. We also evaluated HN action on the proapoptotic effect of TNF-&#945; in anterior pituitary cells assessed by the TUNEL method. HN (5 µM) per se did not modify basal apoptosis of anterior pituitary cells but completely blocked the proapoptotic effect of TNF-&#945; in total anterior pituitary cells, lactotropes and somatotropes from both female and male rats. Also, HN inhibited the apoptotic effect of TNF-&#945; on pituitary tumor cells. In summary, our results demonstrate that HNr is present in the anterior pituitary gland, its expression showing sexual dimorphism, which suggests that gonadal steroids may be involved in the regulation of HNr expression in this gland. Antiapoptotic action of HN in anterior pituitary cells suggests that this peptide could be involved in the homeostasis of this gland. HNr is present and functional in GH3 cells, but it lacks regulation by estrogens, suggesting that HN could participate in the pathogenesis of pituitary tumors.","palabras_clave":"HUMANIN|GH3|PITUITARY|APOPTOSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":32904,"idioma_id":5,"titulo":"Evaluación ?in vitro? de Mentha arvensis para el control de Ascosphaera apis en abeja melifera. Toxicidad en abeja adulta.","resumen":"Introducción: la ?ascosferosis? es una micosis de la abeja melífera (Apis mellifera, L.) causada por Ascosphaera apis (Maassen ex Claussen) Olive &amp; Spiltoir, Fam. Ascosphaeracea, que provoca la momificación de las larvas de la abeja en estado de cría operculada. La enfermedad produce disminución en la población de abejas, reduciendo la producción de miel y la eficiencia en la polinización. Los aceites esenciales, extraídos de plantas aromáticas, son eficaces para el control de las enfermedades de A. mellifera, L. Los objetivos del trabajo fueron: a) determinar la actividad ?in vitro? del aceite esencial de menta japonesa sobre A. apis y, b) determinar la toxicidad oral aguda de la esencia sobre abeja adulta. Materiales y Métodos: se emplearon 9 cepas de A. apis provenientes de Chile (IX y X Región) y Argentina (Buenos Aires, Córdoba y Neuquén). Se testeó la esencia de menta japonesa (Mentha arvensis L.), Flia. Lamiaceae. El aceite esencial se obtuvo por hidrodestilación mediante un aparato tipo&nbsp;Clevenger. Se determinó la concentración mínima inhibitoria (CMI) de la esencia en seis concentraciones (50, 100, 200, 400, 800, 1600 ppm). El disolvente utilizado fue propilenglicol (PG) al 1,70 %. Se utilizaron dos controles: crecimiento y disolvente. Se empleó el método de difusión en agar. El inóculo se realizó en medio MY20, a partir de cultivos de A. apis incubados durante 7-10 días a 35ºC. En la placa con el hongo, se efectuaron orificios de 7 mm con sacabocado estéril. Las secciones con el hongo fueron sembradas en placas con medio MY20, aceite esencial y diluyente. Se&nbsp; incubaron a 35°C en la oscuridad, con lecturas a 24, 48 y 72 horas. Los datos fueron analizados por ANOVA y LSD. Se calculó la Dosis Letal Media (DL50) de la esencia en abejas adultas. Las dosis empleadas fueron: 1, 2, 4, 8, 16 y 32 &#956;g de p.a.\/abeja. Se utilizó dimetoato y PG al 1,70 % en sacarosa al 50 %, como controles tóxico y disolvente, respectivamente. Se registró la mortalidad de abejas adultas a las 24, 48 y 72 horas. La DL50 fue evaluada con el Programa PROBIT. Resultados: el perfil de susceptibilidad de las cepas estudiadas mostró diferencias significativas (p = 0,0184). La prueba de LSD diferenció dos grupos; tres aislamientos de Argentina (Neuquén, Córdoba y Buenos Aires) y dos de Chile (Región X) presentaron diferencias significativas con el procedente de La Plata (Buenos Aires). Después de 72 horas la CMI90 y CMI50 de la esencia sobre A. apis fueron 800 y 400 ppm, respectivamente. La DL50 de la esencia sobre abeja adulta a 24, 48 y 72 horas presentó un nivel mayor a 100 µg p.a.\/abeja, lo que la sitúa dentro del rango de productos ?virtualmente no tóxicos?. Por otro lado, el dimetoato arrojó valores de DL50 dentro del&nbsp; rango esperado para productos ?altamente tóxicos?, de 0,27; 0,20 y 0,12 µg p.a.\/abeja a 24, 48 y 72 horas, respectivamente. Conclusión: los resultados obtenidos resultan promisorios, por lo cual alientan a seguir con esta investigación. ","palabras_clave":"ACEITE ESENCIAL|MENTA|ASCOSFEROSIS|CONTROL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33050,"idioma_id":10,"titulo":"Karyotype evolution in progress: A new diploid number in Belostoma candidulum (Heteroptera: Belostomatidae) from Argentina leading to new insights into its ecology and evolution","resumen":"A novel chromosome complement (2n = 14 = 12 + XY\/XX; male\/female sex chromosomes), male meiosis behaviour, heterochromatin characterization, and frequency and distribution of chiasmata are described for the first time in specimens from a natural population of the giant water bug, Belostoma candidulum Montandon, 1903 (Heteroptera: Belostomatidae) from Argentina. To date, specimens of B. candidulum have been reported by other authors in a sample from a natural population from Brazil. Our results demonstrate that Argentinean and Brazilian populations have different diploid numbers and chromosomal features. During male meiosis,  autosomal bivalents generally show a single chiasma, behave as telokinetic chromosomes (i.e. kinetic activity is restricted to terminal  regions), and divide reductionally at anaphase I; in contrast, the sex chromosomes are achiasmatic, behave as univalents and segregate  equationally at anaphase I. Among autosomal bivalents of B. candidulum, one is remarkably larger and may present one or two terminal  chiasmata, showing rod, V-shaped and ring configurations. Here we propose a new mode of segregation for ring bivalents, since it is not essential that one of the chiasmata is released during anaphase I because alternative sites for microtubule attachment become functional for the normal chromosome segregation to the poles. Heterochromatin content is very scarce in specimens from Argentinean B. candidulum populations, revealing C-positive interstitial and terminal dots in three pairs of autosomes and C-blocks at both ends of X chromosome, whereas the Y chromosome is mainly C-positive. One of the C-positive bands from X and Y chromosomes is DAPIdull\/CMA-bright, which could represent the nucleolus organizing region (NOR) detected by fluorescent in situ hybridization (FISH). The location of the NORs in both sex chromosomes allowed us to use them as a cytological marker to describe their behaviour during  meiosis. Despite the fact that specimens from the Argentinean and Brazilian populations have been classified as a single species due  to their morphological similarity, our results suggest that both populations are chromosomal races or even morphologically-identical  cryptic species. The results obtained support the hypothesis that karyotype of B. candidulum originated through autosomal fusions and  the fusion of the X and Y chromosomes with the ancestral NOR-autosomal pair. Lastly, the genus Belostoma represents an excellent model for assessing the main mechanisms involved in the karyotype evolution in organisms with holokinetic chromosomes, from which inferences may be made concerning its broader ecology and evolution.","palabras_clave":"HETEROPTERA|BELOSTOMATIDAE|BELOSTOMA CANDIDULUM|HOLOKINETIC CHROMOSOMES|RING BIVALENTS|CHROMOSOMAL RACES|CRYPTIC SPECIES|KARYOTYPE EVOLUTION|rDNA-FISH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33081,"idioma_id":4,"titulo":"Riboflavin producing lactic acid bacteria as a biotechnological strategy to obtain bio-enriched soymilk","resumen":"Riboflavin (vitamin B2) plays an important role in cellular metabolism participating in numerous oxidation?reduction reactions and energy usage. In this work, lactic acid bacteria that can produce vitamin B2 in soymilk were identified from 179 strains tested that were previously isolated from a wide range of food products. Only 42 strains were able to grow in a commercial riboflavin-free medium after which the concentration of this vitamin was determined by HPLC. Five of these strains were pre-selected for their capacity to produce elevated concentrations of riboflavin. Thesewere then inoculated in soymilk to evaluate their capacity to growin this food matrix and increase its lowriboflavin concentrations. Only the strain Lactobacillus plantarum CRL 725 was able to significantly increase the initial concentration of riboflavin in soy milk from 309 ± 9 ng\/mL to 700 ± 20 ng\/mL after 12 h of incubation at 37 °C. Roseoflavin resistant variants of this strain were obtained and evaluated in soymilk. One of the variant strains increased 6 times (1860 ± 20 ng\/mL) the initial riboflavin levels of soy milk. Roseoflavin-resistant strains capable of synthesizing riboflavin in soymilk constitute an interesting and economically feasible biotechnology strategy that could be easily adapted by the food industry to develop novel vitamin-bioenriched functional foods with enhanced consumer appeal.","palabras_clave":"RIBOFLAVIN|SOY MILK|LACTIC ACID BACTERIA|BIO-ENRICHMENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33161,"idioma_id":5,"titulo":"Milena Agus. Alice","resumen":"sENCILLEZ, CALIDEZ Y AFECTO; SENSIBILIDAD Y FINA IRONÍA SON CARACTERÍSTICAS QUE SE DESTACAN EN LA ÚLTIMA NOVELA DE MILENA AGUS, NUEVA EXPONENTE DE LA LITERATURA SARDA.","palabras_clave":"MILENA AGUS|ALICE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33277,"idioma_id":4,"titulo":"Partial Differential Equations as Three-Dimensional Inverse Problem of  Moments","resumen":"We considerer partial differential equations of second order, for example the Klein-Gordon equation, the Poissonequation, on a region E = (a1; b1) X (a2; b2) X (a3; b3). We will see that with a common procedure in allcases, we can write the equation in partial derivatives as an Fredholm integral equation of first kind and will solvethis latter with the techniques of inverse problem moments. We will find an approximated solution and bounds forthe error of the estimated solution using the techniques on problem of moments.","palabras_clave":"Partial differential equations|Fredholm integral equations|Generalized moment problem"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33288,"idioma_id":4,"titulo":"A gradient-based strategy for the one-layer RTO+MPC controller","resumen":"In the process industries model predictive controllers (MPC) have the task of controlling theplant ensuring stability and constraints satisfaction, while an economic cost is minimized. Usually the economic objective is optimized by an upper level Real Time Optimizer (RTO) that passes the economically optimal setpoints to the MPC level. The drawback of this structure is the possibleinconsistence\/unreachability of those setpoints, due to the different models employed by the RTO and the MPC, as well as their different time scales. In this paper an MPC that explicitly integrates the RTO structure into the dynamic control layer is presented. To overcome the complexity of this one-layer formulation a gradient-based approximation is proposed, which provides a low-computational-cost suboptimal solution.","palabras_clave":"Model Predictive Control|Economics|Stability|Real Time Optimizer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33315,"idioma_id":4,"titulo":"Study of the Experimental Conditions and Mechanisms for Diclofenac Loading in Functionalized Magnetic Nanoparticles","resumen":"ABSTRACTMagnetic nanoparticles (MNPs) composed of magnetite coated with oleic acid and functionalized with chitosan have been prepared to thetargeted release of the non steroidal anti-inflammatory drug (NSAID) Diclofenac. Two procedures to incorporate the drug were explored:simple adsorption and covalent linkage. The impact of experimental variables such as the nature of the NSAID (commercial versusanalytical sodium Diclofenac), its concentration and amount of coupling agent were evaluated in terms of the loading efficiency and theproperties of interest of MNPs (size, surface functionality, stability). Loaded and unloaded MNPs were characterized by FTIR-DRIFTSspectroscopy, dynamic light scattering, zeta potential and transmission electron microscopy. UV-visible quantification of Diclofenac wasachieved reaching values of loading efficiency between 11 and 27% depending on the experimental conditions. Probable mechanisms fordrug-MNPs interactions have been proposed on the base of characterization data.A nanocarrier of size lower than 150 nm, with satisfactory loading skill and high dispersion capability on water was obtained. The releasebehavior demonstrated to be independent on the presence of an external magnetic field. The properties found in these nanosystemsresult relevant in view of their effective in vivo implementation.","palabras_clave":"MAGNETIC NANOPARTICLES|CHITOSAN|DICLOFENAC|DRUG TARGET"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33350,"idioma_id":4,"titulo":"Observer-based adaptive control using multiple-models switching and tuning","resumen":"Despite the remarkable theoretical accomplishments and successful applications of adaptive control, this field is not mature enough to solve challenging problems where strict performance and robustness guarantees are required. The needs of an approach that explicitly accounts for robust performance and stability specifications is a critical to the design of practical adaptive control systems. Towards this goal, this study extends the robust adaptive controller using multiple models, switching and tuning to multiple input multiple output and non-linear systems. The use of ?extended superstability?, instead of superstability, allows us to establish overall performance guarantees and reduce the conservativeness of the resulting closed-loop system. The authors show that under the proposed framework, the output and states remain bounded for bounded disturbances, as a direct consequence of the passivation properties of superstability. The effectiveness of the proposed algorithm is demonstrated in numerical simulations of a non-linear continuous stirred tank reactor.","palabras_clave":"ADAPTIVE CONTROL|SYSTEM PASSIVATION|SWITCHING|ROBUST CONTROL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33391,"idioma_id":5,"titulo":"El modelo estándar de la aritmética: recursividad y lógica de primer orden","resumen":"En este trabajo, argumentaré a favor de la posibilidad de capturar el modelo estándar de la aritmética, utilizando la lógica clásica de primer orden como lógica subyacente. Como es sabido, las teorías aritméticas formuladas en un lenguaje de primer orden poseen modelos que, si bien satisfacen sus oraciones, difieren estructuralmente del modelo estándar. A estos modelos se los denomina modelos no estándar de la aritmética y deberemos lidiar con ellos a los fines de diferenciarlos del modelo estándar. En esta tarea, el concepto de recursividad, en el plano técnico, y computabilidad, en el plano filosófico, constituyen la clave de la propuesta que sostendré en este trabajo. En este sentido, luego de algunas precisiones introductorias, defenderé la línea argumentativa iniciada por Halbach y Horsten (2005) y discutiré la tesis, sostenida entre otros por Shapiro (1991) y por Barrio (XXX), que propugna la necesidad de usar lógica de segundo orden.","palabras_clave":"MODELOS ESTÁNDAR|PRIMER ORDEN|RECURSIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33398,"idioma_id":4,"titulo":"Second-order chromatographic photochemically-induced fluorescence emission data coupled to chemometric analysis for the simultaneous determination of urea herbicides in the presence of matrix co-eluting compounds","resumen":"      This  paper presents a novel approach for the simultaneous determination of isoproturon,  rimsulfuron and monuron, three widely used urea-derivative herbicides, in  interfering environmental samples, combining the advantages of photoinduced  fluorescence (PIF) emission, liquid chromatography and second-order chemometric  algorithms. Chromatographic detection is made with a fast-scanning  spectrofluorimeter, which allowed the efficient collection of PIF through a  post-column photoreactor. Thus, second-order  elution time-PIF emission data matrices are rapidly obtained (in less than 4  min) with a chromatographic system operating in isocratic regime using a  minimal amount of organic solvent. The goal of the present study was the successful  resolution of a system in the presence of foreign compounds which can be present in real samples. The study was  employed for the discussion of the scopes of the applied second-order  algorithms selected for data  processing, namely parallel  factor analysis (PARAFAC), multivariate curve resolution- alternating  least-squares (MCR-ALS), and multidimensional and unfolded partial  least-squares coupled to residual bilinearization (N- and U-PLS\/RBL). U-PLS\/RBL  showed the best performance to quantify the herbicides, even when the foreign  compounds showed very similar spectral and time profiles to the analytes. The quality of the proposed technique was  assessed on the basis of the analytical recoveries from different types of  water samples spiked with analytes and other selected agrochemicals. After a  solid-phase extraction, reaching a preconcentration factor of 50, detection limits  of 2.9, 2.4, and 1.7 ng mL?1 for isoproturon, rimsulfuron, and  monuron, respectively, were obtained in those interfering matrices, with  relative prediction errors lower than 5 %.  ","palabras_clave":"CROMATOGRAFÍA|FLUORESCENCIA FOTOINDUCIDA|QUIMIOMETRÍA|HERBICIDAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33416,"idioma_id":4,"titulo":"Towards a paradigm shift in the treatment of chronic chagas disease","resumen":"Treatment for Chagas disease with currently available medications is recommended universally only for acute cases (all ages) and for children up to 14 years old. The World Health Organization, however, also recommends specific antiparasite treatment for all chronic-phase Trypanosoma cruzi-infected individuals, even though in current medical practice this remains controversial, and most physicians only prescribe palliative treatment for adult Chagas patients with dilated cardiomyopathy. The present opinion, prepared by members of the NHEPACHA network (Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas\/New Tools for the Diagnosis and Evaluation of Chagas Disease Patients), reviews the paradigm shift based on clinical and immunological evidence and argues in favor of antiparasitic treatment for all chronic patients. We review the tools needed to monitor therapeutic efficacy and the potential criteria for evaluation of treatment efficacy beyond parasitological cure. Etiological treatment should now be mandatory for all adult chronic Chagas disease patients.","palabras_clave":"CHAGAS DIASEASE|ETIOLOGICAL TREATMENT|TREATMENT EFFICACY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33421,"idioma_id":4,"titulo":"Galacto-oligosaccharides and lactulose as protectants against desiccation of Lactobacillus delbrueckii subsp. bulcaricus","resumen":"Lactobacillus delbrueckii subsp. bulgaricus CIDCA 333 was dehydrated on desiccators containing silica gel in the presence of 20% w\/w of two types of galacto-oligosaccharides (GOS Biotempo and GOS Cup Oligo H-70® ) and lactulose, until no changes in water desorption were detected. After rehydration, bacterial growth was monitored at 37°C by determining: (a) the absorbance at 600 nm and (b) the near infrared spectra (NIR). Principal component analysis (PCA) was then performed on the NIR spectra of samples dehydrated in all conditions. A multiparametric flow cytometry assay was carried out using carboxyfluorescein diacetate and propidium iodide probes to determine the relative composition of damaged, viable, and dead bacteria throughout the growth kinetics. The absorbance at 600 nm and the position of the second derivative band at 1370 nm were plotted against the time of incubation. The efficiency of the protectants was GOS Biotempo,&#8201;&#8201;GOS Cup Oligo H-70® ,&#8201;lactulose. The better protectant capacity of GOS Biotempo was explained on the basis of the lower contribution of damaged cells immediately after rehydration (t&#8201;=&#8201;0). PCA showed three groups along PC1, corresponding to the lag, exponential and stationary phases of growth, which explained 99% of the total variance. Along PC2, two groups were observed, corresponding to damaged or viable cells. The results obtained support the use of NIR to monitor the recovery of desiccated microorganisms in real time and without the need of chemical reagents. The use of GOS and lactulose as protectants in dehydration\/rehydration processes was also supported","palabras_clave":"Lactobacillus|damage|dessication|galacto-oligosaccharides"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33432,"idioma_id":4,"titulo":"Catalytic Efficacy of Copper(II)- and Cobalt(III)-Schiff Base Complexes in Alkene Epoxidation","resumen":"A potentially hexadentate N2O4 donor Schiff base ligand N,N¤-bis(5-bromo-3-methoxysalicylideneimino)-1,3-diaminopropane (H2L1) has been used to synthesize two mononuclear coordination complexes [Cu(L1)]¢H2O (1) and  [Co(L1)(HL2)]ClO4¢CH3CN (2). The cobalt complex is a unique mixed-ligand species comprising both the di- and monocondensed ligands; the latter (HL2) resulted from in situ hydrolytic cleavage of H2L1. Ligand L1 assumes a planar arrangement in 1 and a folded &#946;-cis configuration in 2, induced in this case by the chelating HL2 ligand. The complexes are characterized by elemental analyses, FT-IR, and UVvis spectral methods, and their structures are established by single-crystal X-ray diffraction study. Both the complexes are proven to be efficient catalysts for the epoxidation of alkenes by H2O2 or PhIO. The efficiency of alkene epoxidation is however somewhat superior with PhIO, and in each case, 2 appears to be a slightly better catalyst than 1.","palabras_clave":"METAL COMPLEXES|STRUCTURE|CATALYTIC ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33514,"idioma_id":4,"titulo":"The Aplicattion of K phosphites to seed tubers enhanced emergence, early growth and mycorrhizal colonization in Potato (Solanum tuberosum).","resumen":"Rapid emergence and a vigorous growth prevent the seed tubers from infections by soil microbes and allow a rapid interception of solar radiation. In this work, the effect of the potassium phosphites (KPhi) applied to seed tubers of two potato cultivars on crop emergence and early growth was studied. Two experiments were per-formed under greenhouse and field conditions. Emergence of plants, leaf area, dry matter and the number of primary stems were measured in both experiments. Furthermore, mycorrhizal colonization was also measured on roots under field conditions. The application of KPhi reduced the period between planting and emergence, and increased leaf area and dry matter. The ratio between dry matter of aerials and underground organs was not affected by KPhi. Indigenous mycorrhizal colonization increased after KPhi application to seed tubers. These results confirm the benefit of the application of KPhi to seed tubers on early plant growth and suggest that their application in crop production would be advantageous.","palabras_clave":"PHOSPHITES|SEED TUBERS|EMERGENCE|EARLY GROTWH|MYCORRIZAL|POTATO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33523,"idioma_id":5,"titulo":"Gaïa y la diplomacia como dispositivo  cosmopolítico. Entrevista a Bruno Latour","resumen":"RESUMEN:Las preguntas que dan cuerpo a la entrevista que sigue se gestaron en el seno del Núcleo Naturaleza Cultura, un espacio de formación e investigación que nació a inicios de 2013, en el Instituto de Antropología de Córdoba, y que congrega a docentes y estudiantes de grado y posgrado del área de la antropología y la arqueología. Nuestros intereses, desde el inicio, se vincularon a la discusión del par naturaleza-cultura, tal y como se lo discute actualmente en una antropología interesada por el denominado giro ontológico. En este contexto, la obra de Bruno Latour constituye un punto de inflexión indiscutible al momento de considerar las consecuencias políticas, ecológicas y cosmopolíticas de este giro.","palabras_clave":"Cosmopolítica|Actor-Red|Diplomacia|Latour"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33539,"idioma_id":5,"titulo":"Escritura, poder y memoria en las reducciones jesuíticas del Paraguay: trayectorias de líderes indígenas en tiempos de transición","resumen":"La producción de manuscritos fue un aspecto relevante de la participación indígena en el proceso de conversión religiosa en las misiones jesuíticas del Paraguay. El  hallazgo de gran cantidad de textos escritos por los indígenas en diferentes  soportes y con diversas finalidades, ha contribuido a abrir un nuevo campo de  investigación y a revisar algunos de los antiguos supuestos. En el contexto de transición que marca la etapa posterior a la expulsión de los jesuitas, la escritura indígena comenzó  a asumir, por un lado, una función protocolar, estableciéndose como una nueva  manera de comunicación directa entre los líderes indígenas y la administración  colonial. Sugerimos que los líderes indígenas eran conscientes de las mudanzas introducidas  en los lugares de poder, con posterioridad al tratado de límites, e  instrumentaron la escritura para redefinir su posición en el mapa general de  relaciones políticas. Por otro lado, la escritura indígena se afirmó como un  modo de construir liderazgo, historia y memoria, a través de la definición de  redes epistolares, y un registro preciso de efemérides y acontecimientos en los  cuales habían estado involucrados los escribientes y sus antepasados.","palabras_clave":"escritura|misiones|jesuitas|agencia indígena"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33613,"idioma_id":4,"titulo":"Tutorial Practice as a Strategy of Retention at the School of Engineering","resumen":"Among the many problems facing higher education today, one in particular concerns the Argentine State and it is the low rates of graduation at public universities. International experience shows that college dropout is a widespread problem that occurs in public and private universities and has social costs that justify public policy actions that tend to their decline. Engineering went from being the most chosen career to reaching the eighth place in the ranking of carrers with greatest number of graduates in 2008. The problem of low graduation rate is closely linked to a phenomenon that mainly occurs in the early stages of the studies at this level, which is dropping out and decreasing of tuition.In this framework, the first decade of the XXI century is the historical context in which tutorial practices were installed in engineering careers in Argentina in order to promote the retention of students in the first years of college education, with the aim to cushion the severe difficulties of articulation between high school and higher education.The study presents an analysis of mentoring as institutional retention strategy, from which we identify the different dimensions that affect the retention of students and a categorization of the factors underlying the permanence of the subjects in the institutional context.","palabras_clave":"Tutorial practice, |mentoring, |college dropout"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33617,"idioma_id":4,"titulo":"A complete assignment of the vibrational spectra of sucrose","resumen":"  In the present study, a complete assignment of the vibrational spectra of sucrose in aqueous medium was  performed combining Pulay?s Scaled Quantum Mechanics Force Field (SQMFF) methodology with selfconsistent  reaction field (SCRF) calculations. Aqueous saturated solutions of sucrose and solutions at different  molar concentrations of sucrose in water were completely characterized by infrared, HATR, and  Raman spectroscopies. In accordance with reported data of the literature for sucrose, the theoretical  structures of sucrose penta and sucrose dihydrate were also optimized in gas and aqueous solution  phases by using the density functional theory (DFT) calculations. The solvent effects for the three studied  species were analyzed using the solvation PCM\/SMD model and, then, their corresponding solvation energies  were predicted. The presence of pure water, sucrose penta-hydrate, and sucrose dihydrate was confirmed  by using theoretical calculations based on the hybrid B3LYP\/6-31G&#8260; method and the experimental  vibrational spectra. The existence of both sucrose hydrate complexes in aqueous solution is evidenced in  the IR and HATR spectra by means of the characteristic bands at 3388, 3337, 3132, 1648, 1375, 1241,  1163, 1141, 1001, 870, 851, 732, and 668 cm1 while in the Raman spectrum, the groups of bands in  the regions 3159?3053 cm1, 2980, 2954, and 1749?1496 cm1 characterize the vibration modes of those  complexes. The inter and intra-molecular H bond formations in aqueous solution were studied by Natural  Bond Orbital (NBO) and Atoms in Molecules theory (AIM) investigation.","palabras_clave":"SUCROSE|VIBRATIONAL SPECTRA|MOLECULAR STRUCTURE|FORCE FIELD|DFT CALCULATIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33636,"idioma_id":5,"titulo":"EVALUACIÓN DE LA ACTIVIDAD ANTIMICROBIANA Y DE LOS EFECTOS SOBRE EL BALANCE OXIDATIVO DEL ANTIMICROBIANO CIPROFLOXACINA Y DE LA TINTURA DE ECHINACEA ANGUSTIFOLIA","resumen":"En la actualidad, existe una gran preocupación basada en la gradual reducción del número de  antimicrobianos eficientes debido a la creciente aparición de microorganismos resistentes a los mismos. Por ello, se  ha incrementado el interés en la búsqueda de nuevos compuestos de origen vegetal que presenten actividad  antimicrobiana. Asimismo, se han llevado a cabo una gran cantidad de investigaciones evaluando efectos tóxicos de  antimicrobianos convencionales y extractos vegetales. En el presente trabajo se comparó la actividad antimicrobiana  de una tintura de Echinacea angustifolia con el antimicrobiano Ciprofloxacina mediante el ensayo de difusión en disco  y las determinaciones de CIM y CBM; y se evaluó el efecto de ambos compuestos sobre el balance oxidativo en  muestras de sangre humana a través del ensayo de TBARs (sustancias reactivas al ácido tiobarbitúrico), y la  cuantificación de las enzimas Superóxido Dismutasa y Catalasa. Si bien no se halló un efecto inhibitorio de la tintura de  Echinacea sobre los microorganismos estudiados, los resultados del ensayo de TBARs en muestras de sangre humana  arrojaron valores decrecientes de oxidación lipídica a mayores concentraciones de tintura, con un valor r =-0,988,  según el Test de Pearson. Por otro lado, las muestras de sangre tratadas con Ciprofloxacina tuvieron un  comportamiento opuesto, exhibiendo valores mayores de lipoperoxidación, a mayores concentraciones del  antimicrobiano. La tintura de E. angustifolia es una potencial herramienta terapéutica que debería ser objeto de más  investigaciones, con el fin de ser empleada en una gran variedad de procesos patológicos en los que interviene el  estrés oxidativo.","palabras_clave":"Echinacea angustifolia|Antioxidante|Ciprofloxacina|Antimicrobiano"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33664,"idioma_id":5,"titulo":"Evaluación de Sistema Fotovoltaico en Edificio Comercial Conectado a Red de Distribución en la Provincia de San Juan","resumen":"En zonas con potencial de recurso solar se hace imprescindible analizar la posibilidad de utilizar generación fotovoltaica (FV) como fuente de generación eléctrica, considerando factores técnicos, económicos y ambientales. En la Provincia de San Juan, con un recurso solar abundante, la Universidad Nacional de San Juan en cooperación con el Gobierno de la provincia y la Empresa Distribuidora Eléctrica de Caucete (DECSA) viene desarrollando proyectos de generación solar fotovoltaica (FV) en conjunto, con el objetivo de acrecentar la aplicación de la tecnología FV en generación distribuida a pequeña-mediana escala.En el presente trabajo se describe la instalación de un sistema FV comercial conectado a la red eléctrica de distribución. Se analiza el diseño del sistema y de la estructura soporte, se realiza una evaluación de la energía generada y los índices de producción y pérdida. Se presentan los resultados y conclusiones más relevantes hasta esta etapa.","palabras_clave":"ENERGIA SOLAR|GENERACION FOTOVOLTAICA|CONECTADA A RED|SECTOR COMERCIAL|EVALUACION TECNICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33732,"idioma_id":4,"titulo":"Model predictive control suitable for closed-loop re-identification","resumen":"The main problem of a closed-loop re-identification procedure is that, in general, the dynamic control andidentification objectives are conflicting. In fact, to perform a suitable identification, a persistent excitationof the system is needed, while the control objective is to stabilize the system at a given equilibrium point.However, a generalization of the concept of stability, from punctual stability to (invariant) set stability,allows for a flexibility that can be used to avoid the conflict between these objectives. Taking into accountthat an invariant target set includes not only a stationary component, but also a transient one, the systemcould be excited without deteriorating the stability of the closed-loop. In this work, a MPC controller isproposed that ensures the stability of invariant sets at the same time that a signal suitable for closedloopre-identification is generated. Several simulation results show the propose controller formulationproperties.","palabras_clave":"Model Predictive Control|Closed-loop Identification|Target set Control|Persistent Excitation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33785,"idioma_id":4,"titulo":"Distribution of chromium species in a Cr-polluted soil: presence of Cr(III) in glomalin related protein fraction","resumen":"MMMMM","palabras_clave":"POTENTIALLY TOXIC ELEMENTS|TRIVALENT AND HEXAVALENT CHROMIUM|GLOMALIN RELATED SOIL PROTEIN|ARBUSCULAR MYCORRHIZAL FUNGI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33926,"idioma_id":4,"titulo":"Influence of experimental thermal shifts and overcrowding on fecundity in wild females of Acartia tonsa of the Bahía Blanca estuary","resumen":"The copepod Acartia tonsa plays an important role in the food web of many estuaries influenced by changes due to anthropic activities, hence it is relevant to know its reproductive plasticity under stressful conditions. We examined the influence of thermal shift (6 ± 1ºC and 18 ± 1ºC) and overcrowding stress on egg production and hatching success in wild females of A. tonsa of the Bahía Blanca Estuary. Egg production rate (EP), hatching success during seven days (E7 %) and time taken to hatch 50 % of eggs (T 50) were registered. The high individual density used in the incubations caused a decrease in EP values at both temperatures. Nevertheless, all the females responded favorably to 18°C. EP and E7 % obtained at both temperatures were significantly different the values at 18ºC, being twice as high as those obtained at 6°C. T 50 values at 18ºC indicated a shorter developmental time in eggs from spring females, whereas the opposite effect was observed in eggs from winter females. Our results indicate that the reproductive performance is affected by short exposures to thermal shift. The pattern of egg production and hatching is also modified in accordance with the maternal history.","palabras_clave":"ACARTIA TONSA|FECUNDITY|THERMAL SHIFT|WILD FEMALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":33981,"idioma_id":5,"titulo":"Un panorama sobre los inmigrantes y la escuela en Argentina, 1884-1938","resumen":"El artículo trata sobre la presencia inmigrante en las escuelas nacionales durante el período 1884-1938. A través de la investigación se profundizó en la dinámica de integración de los inmigrantes a partir de la escuela y se analizó el proceso de escolarización y alfabetización de la población inmigrante no sólo desde el Estado sino desde la sociedad y desagregando en ella a los extranjeros.","palabras_clave":"EDUCACION|INMIGRACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34050,"idioma_id":4,"titulo":"A probabilistic model for the spoilage wine yeast Dekkera\/Brettanomyces bruxellensis as a function of pH, ethanol and free SO2 using time as dummy variable","resumen":"The present study uses a probabilistic model to determine the growth\/no growth interfaces of the spoilage wine yeast Dekkera bruxellensis CH29 as a function of ethanol (10-15%, v\/v), pH (3.4-4.0) and free SO2 (0-50 mg\/l) using time (7, 14, 21 and 30 days) as a dummy variable. The model, built with a total of 756 growth\/no growth data obtained in a simile wine medium, could have application in the winery industry to determine the wine conditions needed to inhibit the growth of this species. Thereby, at 12.5% of ethanol and pH 3.7 for a growth probability of 0.01, it is necessary to add 30 mg\/l of free SO2 to inhibit yeast growth for 7 days. However, the concentration of free SO2 should be raised to 48 mg\/l to achieve a probability of no growth of 0.99 for 30 days under the same wine conditions. Other combinations of environmental variables can also be determined using the mathematical model depending on the needs of the industry.","palabras_clave":"GROWTH\/NO GROWTH BOUNDARIES|LOGISTIC MODEL|WINE SPOILAGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34131,"idioma_id":5,"titulo":"Editorial setiembre 2014","resumen":"En anexo","palabras_clave":"Agricultura|Familiar|Politicas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34205,"idioma_id":4,"titulo":"High-throughput method based on quick, easy, cheap, effective, rugged and safe followed  by liquid chromatography-multi-wavelength detection for the quantification of multiclass polyphenols in wines","resumen":"In this work, a reliable, simple, fast, inexpensive and robust sample preparation approach for the determination of multiclass polyphenols in wine samples is proposed. The polyphenols selected for this work were gallic acid, (+)-catechin, (-)-epicatechin, caffeic acid, syringic acid, coumaric acid, ferulic acid, trans-resveratrol, quercetin and cinnamic acid. The method is based on QuEChERS (quick, easy, cheap, effective, rugged and safe) extraction technique coupled with dispersive solid-phase extraction (d-SPE) clean-up. Under optimized conditions, the analytes were extracted from 5 mL wine samples (previously acidified with 1 % formic acid) using 2.5 mL acetonitrile. For phase separation, 1.5 g NaCl and 4 g anhydrous MgSO4 were added. Then, a 1 mL aliquot of the partitioned supernatant was cleaned-up using d-SPE with a combination of 150 mg CaCl2, 50 mg primary-secondary amine (PSA) and 50 mg C18 as sorbents. A 250 µL aliquot of the obtained cleaned extract was concentrated to dryness and taken up with the initial mobile phase previous to liquid chromatography-multi-wavelength detection (LC-MWD).  The proposed method provided limits of detection (LODs) ranging from 0.004-0.079 µg mL-1 and an inter-day variability below 12 % RSD for all analytes in red and white wine samples. Considering external calibration (red wines) and matrix-matched calibration (white wines) as quantification techniques, the overall recoveries (accuracy) of the method ranged between 75.0 % and 119.6 % for red and white wine samples, respectively. The developed method was applied for the determination of polyphenols in 10 wines produced in Argentina. Nine phenolic compounds were determined, at concentrations above detectable levels in the method. The maximum concentrations corresponded to (-)-epicatechin in white wines, while gallic acid and (+)-catechin were the most abundant in red wines.","palabras_clave":"polyphenols|wine|method"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34244,"idioma_id":4,"titulo":"Ibero-American Online News Managers. Goals and Handicaps in Managing Social Media","resumen":"This article presents the results of a study of social media uses and standards from the perspectives of online newspaper managers in Argentina, Colombia, Peru, Mexico, Venezuela, Spain, and Portugal.1 Interviews with online news managers and a content analysis of journalists? use of Facebook and Twitter accounts show that cultural, economic, and organizational factors handicap news outlets? adoption of social media. At the same time, evidence shows that these professionals? drive and enthusiasm for transitioning to online and using social media have made meaningful changes in the ways news is produced in the Ibero-American region","palabras_clave":"JOURNALISM|SOCIAL MEDIA|FACEBOOK|TWITTER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34252,"idioma_id":4,"titulo":"Refactoring and AOP under Scrutiny","resumen":"A conflict between refactoring and AOP techniques can arise whenever an application with aspects is subjected to a refactoring application. When the units of code being restructured are also part of a pointcut definition, changes in the external behaviour of the application can occur. This study presents an approach to anticipate the impact of refactoring changes in AO applications. We first decompose refactorings into atomic change operations. Then we individually analyse and evaluate each of these operations. The overall results anticipate the consequences of the refactoring. Our approach is partially automated. We also provide some examples and introduce a discussion (left open in this work) about the relation-ship between different variables that characterize the refactorings.","palabras_clave":"aop|REFACTORING|SOFTWARE EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34273,"idioma_id":5,"titulo":"El empoderamiento en el aula de lenguas extranjeras: una propuesta desde el análisis crítico del discurso y la Teoría de la Valoración.","resumen":"Sobre la certeza del gran potencial de aplicabilidad del Análisis Crítico del Discurso (ACD) en contextos educativos, este trabajo propone desarrollar las habilidades de lectura de los alumnos universitarios por medio de la implementación de estrategias de desarrollo de conciencia crítica (Fairclough, 1992) haciendo uso de las herramientas de análisis del lenguaje postuladas desde la Teoría de la Valoración (Martin & White, 2005) en el marco de la Lingüística Sistémico Funcional (LSF). Ilustramos esta propuesta con el análisis de un artículo periodístico publicado en el diario New York Times sobre la muerte del ex-presidente de Argentina Néstor Kirchner.","palabras_clave":"ACD (Análisis Crítico del Discurso)| Conciencia Crítica|Lenguas Extranjeras|Teoría de la Valoración"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34275,"idioma_id":5,"titulo":"La representación discursiva de los intereses: un análisis desde la intersección de la Lingüística Sistémico Funcional y el Análisis Crítico del Discurso","resumen":"El Análisis del Discurso (AD), como rama relativamente moderna de los estudios del lenguaje, propone desentrañar de manera rigurosa y sistemática las representaciones que se construyen en los textos. Este proceso de análisis e interpretación discursiva puede abordarse desde una multiplicidad de perspectivas, cada una de las cuales persigue propósitos específicos funcionales, estructurales, ideológicos, gramaticales, entre muchos otros. La propuesta que presentamos aquí tiende a combinar dos líneas teórico-analíticas del análisis del discurso que han demostrado un gran potencial de fusión: la Lingüística Sistémico Funcional (LSF) (Halliday y Hasan, 1985, Halliday, 1978, 1994, Hasan, 2009) y en particular, en este marco, la Teoría de la Valoración (Martin, 2000; Martin y White, 2005) y el Análisis Crítico del Discurso (ACD) (Fairclough, 1989, 1992, 1995a, 1995b, 1999, 2003,  Wodak, 2001, 2006), y en particular, su enfoque Socio-histórico discursivo (Wodak, de Cillia, Reisigl, y Liebhart, 1999; Reisigl y Wodak, 2001). Este trabajo ilustra esta fusión por medio del análisis de un texto mediático del género noticias publicado en el periódico New York Times. Si bien se presenta un análisis de un texto en inglés, los principios son transferibles al análisis en lenguas maternas, segundas o extranjeras. Presentamos el análisis de un artículo periodístico publicado en el diario New York Times sobre una temática de gran significatividad social: la muerte del ex-presidente de Argentina, Néstor Kirchner.","palabras_clave":"Análisis del Discurso (AD) |Análisis Crítico del Discurso (ACD)|Teoría de la Valoración|discurso mediático"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34277,"idioma_id":5,"titulo":"Producción de saberes de la Psicología Política de la Universidad Nacional de San Luis","resumen":"El Proyecto de Investigación Psicología Política reflexiona sobre las personas y analiza su dimensión subjetiva, recuperando su ?condición humana? a partir desde las mediaciones históricas  micro y macro sociales que lo atraviesan. Es a través de los Ejes Fundamentales que el proyecto despliega su producción de conocimientos científicos, a saber: la concepción y el ejercicio del poder; la distribución del conocimiento validado socialmente; el control social; los derechos humanos y las representaciones sociales de sectores de la realidad. El proyecto ha producido unas 500 publicaciones en Revistas Científicas, cerca de 50 libros, la primera revista virtual sobre la temática en habla hispana, ?Revista Electrónica de Psicología Política?, y se creó la ONG ?Psicólogos Sin Fronteras Argentina?. Pertenece a la Universidad Nacional de San Luis, Argentina, y es dirigido actualmente por el Dr. Elio Rodolfo Parisí.       ","palabras_clave":"Conocimiento|Ejes Fundamentales|Publicaciones|Revista Electrónica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34284,"idioma_id":5,"titulo":"Guía para la Reingeniería de Sistemas Legados: una experiencia práctica y real.","resumen":"Este trabajo presenta una experiencia real de reingeniería de sistemas legados. La misma tuvo lugar en la Administración General de Vialidad Provincial (Santa Cruz) y demandó aproximadamente un año de trabajo. El proyecto de reingeniería tuvo dos objetivos muy concretos: a) desarrollar un marco de trabajo de reingeniería que se adecuara a los sistemas legados de la organización con la finalidad de poder ser replicado a otros sistemas legados de la organización. Este objetivo dio por resultado la elaboración de una guía para su posterior reutiliza-ción a estos contextos. b) su aplicación a uno de los sistemas lega-dos de la organización. En esta primera instancia se aplicó al sistema de Patrimonio.","palabras_clave":"Sistemas legados|Reingenieria |migración|mantenimiento de software"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34286,"idioma_id":4,"titulo":"Importance of molecular genetic analysis in the diagnosis and classification of congenital hypothyroidism.","resumen":"Importance of molecular genetic analysis in the diagnosis and classification of congenital hypothyroidism. ","palabras_clave":"HIPOTIROIDISMO CONGENITO|GEN|TIROGLOBULINA|MUTACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34301,"idioma_id":4,"titulo":"Key design factors affecting microbial community composition and pathogenic organisms removal in horizontal subsurface flow constructed wetlands","resumen":"Constructed wetlands constitute an interesting option forwastewater reuse since high concentrations of contaminants and pathogenic microorganisms can be removed with these natural treatment systems. In this work, the role of key design factors which could affect microbial removal and wetland performance, such as granular media, water depth and season effect was evaluated in a pilot system consisting of eight parallel horizontal subsurface flow (HSSF) constructed wetlands treating urban wastewater from Les Franqueses del Vallès (Barcelona, Spain). Gravel biofilm as well as influent and effluent water samples of these systems were taken in order to detect the presence of bacterial indicators such as total coliforms (TC), Escherichia coli, fecal enterococci (FE), Clostridium perfringens, and other microbial groups such as Pseudomonas and Aeromonas. The overall microbial inactivation ratio ranged between 1.4 and 2.9 log-units for heterotrophic plate counts (HPC), from 1.2 to 2.2 log units for total coliforms (TC) and from 1.4 to 2.3 log units for E. coli. The presence of fine granulometry strongly influenced the removal of all the bacterial groups analyzed. This effect was significant for TC (p = 0.009), E. coli (p = 0.004), and FE (p = 0.012). Shallow HSSF constructed wetlands were more effective for removing Clostridium spores (p = 0.039), and were also more efficient for removing TC (p = 0.011) and E. coli (p = 0.013) when fine granulometry was used. On the other hand, changes in the total bacterial community from gravel biofilm were examined by using denaturing gradient gel electrophoresis (DGGE) and sequencing of polymerase chain reaction (PCR)-amplified fragments of the 16S rRNA gene recovered from DGGE bands. Cluster analysis of the DGGE banding pattern from the different wetlands showed that microbial assemblages separated according to water depth, and sequences of different phylogenetic groups, such as Alpha, Beta and Delta-Proteobacteria, Nitrospirae, Bacteroidetes, Acidobacteria, Firmicutes, Synergistetes and Deferribacteres could be retrieved from DGGE bands.","palabras_clave":"CONSTRUCTED WETLANDS|HORIZONTAL SUBSURFACE FLOW|DESIGN FACTORS|MUNICIPAL WASTEWATER TREATMENT|GRAVEL BIOFILM EXAMINATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34307,"idioma_id":4,"titulo":"Genetic differentiation among populations of the Roseate Spoonbill (Platalea ajaja, Aves: Pelecaniformes) in three Brazilian wetlands","resumen":"Effective population size, levels of genetic diversity, gene flow, and genetic structuring were assessed in 205 colonial Roseate spoonbills from 11 breeding colonies from north, central west, and south Brazil. Colonies and regions exhibited similar moderate levels of diversity at five microsatellite loci (mean expected heterozygosity range 0.50?0.62; allelic richness range 3.17?3.21). The central west region had the highest Ne (59). FST values revealed low but significant genetic structuring among colonies within the north and within the south regions. Significant global genetic structuring was found between the northern and central western populations as well as between the northern and southern populations. An individual-based Bayesian clustering method inferred three population clusters. Assignment tests correctly allocated up to 64% of individuals to their source regions. Collectively, results revealed complex demographic dynamics, with ongoing gene flow on a local scale, but genetic differentiation on a broader scale. Populations in the three regions may all be conserved, but special concern should be given to central western ones, which can significantly contribute to the species? gene pool in Brazil.","palabras_clave":"AQUATIC BIRDS|BREEDING COLONIES|EFFECTIVE POPULATION SIZE|NUCLEAR MARKERS|REGIONAL GENETIC STRUCTURING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34340,"idioma_id":4,"titulo":"Hierarchical and dynamic seascapes: a quantitative framework for scaling pelagic biogeochemistry and ecology","resumen":"Comparative analyses of oceanic ecosystems require an objective framework to define coherent study regions and scale the patterns and processes observed within them. We applied the hierarchical patch mosaic paradigm of landscape ecology to the study of the seasonal variability of the North Pacific to facilitate comparative analysis between pelagic ecosystems and provide spatiotemporal context for Eulerian time-series studies. Using 13-year climatologies of sea surface temperature (SST), photosyn- thetically active radiation (PAR), and chlorophyll a (chl-a), we classified seascapes in environmental space that were monthly-resolved, dynamic and nested in space and time. To test the assumption that seascapes represent coherent regions with unique biogeochemical function and to determine the hierarchical scale that best characterized variance in biogeochemical parameters, independent data sets were analyzed across seascapes using analysis of variance (ANOVA), nested-ANOVA and multiple linear regression (MLR) analyses. We also compared the classification efficiency (as defined by the ANOVA F-statistic) of resultant dynamic seascapes to a commonly-used static classification system. Variance of nutrients and net primary productivity (NPP) were well characterized in the first two levels of hierarchy of eight seascapes nested within three superseascapes (R2 = 0.5?0.7). Dynamic boundaries at this level resulted in a nearly 2-fold increase in classification efficiency over static boundaries. MLR analyses revealed differential forcing on pCO2 across seascapes and hierarchical levels and a 33% reduction in mean model error with increased partitioning (from 18.5 latm to 12.0 latm pCO2). Importantly, the empirical influence of seasonality was minor across seascapes at all hierarchi- cal levels, suggesting that seascape partitioning minimizes the effect of non-hydrographic variables. As part of the emerging field of pelagic seascape ecology, this effort provides an improved means of monitoring and comparing oceanographic biophysical dynamics and an objective, quantitative basis by which to scale data from local experiments and observations to regional and global biogeochemical cycles.","palabras_clave":"North Pacific|Seascapes|Seasonal variations|Pelagic environment|Biogeochemistry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34412,"idioma_id":4,"titulo":"Primordial magnetic fields from a non-singular bouncing cosmology","resumen":"Although inflation is a natural candidate to generate the lengths of coherence of magnetic fields needed to explain current observations, it needs to break conformal invariance of electromagnetism to obtain significant magnetic amplitudes. Of the simplest realizations are the kinetically-coupled theories f^2(&#981;)F&#956;&#957;F&#956;&#957; (or IFF theories). However, these are known to suffer from electric fields backreaction or the strong coupling problem. In this work we shall confirm that such class of theories are problematic to support magnetogenesis during inflationary cosmology. On the contrary, we show that a bouncing cosmology with a contracting phase dominated by an equation of state with p>&#8722;&#961;\/3 can support magnetogenesis, evading the backreaction\/strong-coupling problem. Finally, we study safe magnetogenesis in a particular bouncing model with an ekpyrotic-like contracting phase. In this case we found that f^2(&#981;)F^2-instabilities might arise during the final kinetic-driven expanding phase for steep ekpyrotic potentials.","palabras_clave":"PRIMORDIAL MAGNETIC FIELDS|ALTERNATIVES TO INFLATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34437,"idioma_id":4,"titulo":"Nutritional and sensory quality during refrigerated storage of fresh-cut mints (Mentha x piperita and M. spicata)","resumen":"The effect of storage time on quality attributes of refrigerated fresh-cut mints (Mentha  piperita and M. spicata) was studied. Atmosphere composition, respiratory activity, weight loss, surface colour, total chlorophyll, carotenoids, browning potential, total phenols, flavonoids, radical-scavenging activity, ascorbic acid and essential oil yield and composition were analysed. Respiratory activity of peppermint and spearmint samples diminished moderately (42% and 28%, respectively) after 21 days at 0 C. A slight modification of the internal atmosphere was achieved. Surface colour, chlorophyll, carotenoid and antioxidant compounds remained almost constant. The yield of essential oil did not change or it showed an apparent increase after 21 days at 0 C, depending on plant growth stage. The characteristic flavour components of peppermint (menthone and menthol) increased, while the contents of the main constituents of spearmint essential oil showed minor variations after storage. The conditions assayed for packaging and storing fresh-cut mints were adequate to achieve a relatively long shelf life and they retained their antioxidant properties.","palabras_clave":"Culinary herbs|Mentha spp|Refrigerated storage|Antioxidant compounds"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34441,"idioma_id":5,"titulo":"Función e innovación social, el caso Twitter","resumen":"Twitter es una   aplicación que pertenece a las categorías de microblogging y redes   sociales dentro de lo que se ha denominado web 2.0 y web Social. La   exploración de las relaciones entre la aplicación y las comunidades de   usuarios dan como resultado comportamientos colectivos con funciones   sociales significativas que tienen expresión desde los ámbitos de la   comunicación, la semiótica, la construcción social de información y   conocimiento y otros fenómenos colectivos. Este trabajo inicia la   aproximación al análisis de estas relaciones desde algunas visiones   tradicionales de la filosofía de la tecnología, como la visión sistémica   y la visión de los objetos técnicos, tomando a Twitter como un caso   particular. La identificación y caracterización de algunos elementos   clave en el mecanismo tecnosocial que se produce en el uso, muestra   problemas cuya respuesta está aún pendiente para una entidad que puede   comprenderse tradicionalmente como un objeto formal, pero que tiene   comportamiento artefactual.","palabras_clave":"Twitter|innovación social|emergente"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34456,"idioma_id":5,"titulo":"Aportes sobre la relación de Deleuze con Lacan","resumen":"El psicoanálisis es una referencia decisiva en la filosofía de Deleuze, ya antes de su colaboración con Guattari. Los matices de esta relación, sin embargo, han sido a menudo opacados por su imagen de detractor de la tradición psicoanalítica. Si bien esta percepción no es del todo infundada, resulta incapaz de dar cuenta de la complejidad del lazo. Nuestra propuesta en este artículo es abordar la relación entre Deleuze y el psicoanálisis adoptando como hilo conductor las referencias a Lacan presentes en su obra. Pretendemos así contribuir a la elaboración de un balance más completo de los vínculos entre ambos pensadores, dado que suelen adoptarse versiones simplistas. Con vistas a ello, analizaremos los diferentes momentos de esta historia que, a nuestro juicio, comporta cuatro etapas: la primera, desde el estudio sobre Sacher-Masoch hasta Lógica del sentido, es de índole positiva; la segunda, correspondiente a El Anti-Edipo, está signada por ambivalencias; la tercera, desde este texto hasta Mil Mesetas, muestra un alejamiento irreversible; la última, a partir de dicho libro, manifiesta una indiferencia de Deleuze hacia Lacan y el psicoanálisis en general.","palabras_clave":"DELEUZE|LACAN|DESEO|FALTA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34461,"idioma_id":10,"titulo":"Deleuze: três perspectivas sobre o nilismo","resumen":"O presente trabalho aborda a questão do niilismo no pensamento de Gilles Deleuze. A nossa hipótese é que a abordagem do problema na sua leitura de Nietzsche deve ser articulada com outros dois momentos da sua obra: a elaboração de uma moral do acontecimento e a proposta de uma ética da crença. Nos três casos, Deleuze conecta uma determinada caraterização do niilismo com a invenção de um novo modo de existência, o qual revela tanto uma continuidade nos seus enfoques como certas variações terminológicas. Assim, no interior da ontologia nietzschiana das forças, define o niilismo pela depreciação da vida e o triunfo do ressentimento, e introduz a afirmação da vida e do super-homem. Logo, no marco da ontologia do acontecimento, propõe o amor fati como atitude do homem livre que elude o ressentimento perante o acontecimento. Por último, no horizonte da ética da confiança, de cara à ruptura do laço com o mundo, demanda uma forma de ser capaz de sustentar uma crença neste mundo. Propomo-nos analisar essas três perspectivas com o fim de oferecer uma visão integral da temática do niilismo na filosofia deleuziana ","palabras_clave":"ACONTECIMIENTO|NIILISMO|IMANÊNCIA|RESSENTIMENTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34464,"idioma_id":5,"titulo":"Del resentimiento a la creencia en este mundo. El problema del nihilismo en la obra de Deleuze","resumen":"En este artículo desarrollamos tres perspectivas sobre el problema del nihilismo en la obra de Gilles Deleuze. Nuestro autor articula la caracterización del fenómeno con la invención de un nuevo modo de existencia en tres momentos diferentes de su producción, que revelan tanto una continuidad temática como variaciones conceptuales. En primer lugar, en 'Nietzsche et la philosophie', frente al nihilismo definido por la depreciación de la vida y el triunfo del resentimiento, Deleuze plantea la afirmación de la vida y el superhombre. Luego, en el marco de 'Logique du sens', propone el 'amor fati' como actitud del hombre libre que elude el resentimiento frente al acontecimiento. Por último, en el horizonte de la ética de la confianza bosquejada en 'L´image-temps' y 'Qu´est-ce que la philosophie?', de cara a la ruptura del lazo con el mundo, demanda una manera de ser capaz de sostener una creencia en este mundo.","palabras_clave":"DELEUZE|NIHILISMO|RESENTIMIENTO|CREENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34530,"idioma_id":4,"titulo":"Deformation and fracture behavior of Polypropylene reinforced with fly ash with and without MAPP as coupling agent","resumen":"The deformation and fracture behavior of PP\/ash composites with and without maleic anhydride functionalized  iPP (MAPP) as coupling agent was investigated, focusing on the effect of ash content and loading  conditions. A decreasing trend of tensile strength and strain at break values with filler content was  observed for unmodified composites, whereas these properties were roughly independent of ash content  for the composites with MAPP. In quasi-static fracture tests, all materials displayed ductile behavior.  Most composites exhibited improved fracture properties with respect to the matrix as a result of the  toughening mechanisms induced by the ash particles. Under impact loading conditions, in contrast, all  materials displayed fully brittle behavior. Impact critical fracture energy values of the composites were  higher than those of PP and they also presented a maximum which was explained in terms of the comprehensive  analysis of the crystallinity development in PP. The incorporation of MAPP led to better dispersion  of ash particles in the matrix but was detrimental to the material fracture behavior  independently of loading conditions. Increased interfacial adhesion promoted by MAPP hindered particle-  induced toughening mechanisms.","palabras_clave":"DEFORMACION|FRACTURA|MATERIALES COMPUESTOS|POLIPROPILENO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34549,"idioma_id":4,"titulo":"Strategies in diabetic nephropathy: apelin is making its way","resumen":"Strategies in diabetic  nephropathy: apelin is making  its way   Liliana A.Monasterolo    ´ Area Farmacolog´&#305;a, Facultad de Ciencias  Bioqu´&#305;micas y Farmac´euticas, Universidad  Nacional de Rosario, Consejo Nacional  de Investigaciones Cient´&#305;ficas y T´ecnicas  (CONICET), Rep´ublica Argentina  Email: lmonaste@fbioyf.unr.edu.ar,  l_monasterolo@yahoo.com    Diabetic nephropathy, one of the major  microvascular complications of diabetes, is  a leading cause of end-stage renal disease.  This pathological entity is morphologically  characterized by glomerular hypertrophy  and thickening of tubular basal membranes,  in association with progressive mesangial  expansion.As the disease progresses, clinical  manifestations include albuminuria, hypertension  and declining glomerular filtration  rate. Experimental and clinical studies  have demonstrated the significant role  of various inflammatory molecules in  the setting of diabetic nephropathy,  including acute phase reactants,  inflammatory cytokines, adhesion  molecules and chemokines (for review  see Navarro-Gonz´alez & Mora-Fern´andez,  2008). Current treatment approaches  include renin?angiotensin?aldosterone  system inhibition, dietary sodium  restriction and diuretic therapy.  Nevertheless, new strategies are needed  to slow down progression of diabetic  nephropathy. In this issue of The Journal  of Physiology, Chen and colleagues (2014)  examined a possible mechanism involved  in the beneficial effects of apelin-13 on  experimental diabetic nephropathy.  The adipokine apelin is a peptide  known as the endogenous ligand of the  G-protein-coupled receptor APJ.Apelin-13,  themost activemember of the apelingroup,  has emerged as a beneficial peptide with  anti-obesity and antidiabetic properties,  and thus, as a promising therapeutic  target in metabolic disorders (for review  see Castan-Laurell et al. 2011). Recently,  Day et al. (2013) showed, for the first  time, that apelin-13 exerts renoprotective  effects in diabetic FVB\/Ove26 mice. These  authors observed that the whole-kidney and  glomerular hypertrophy, as well as renal  inflammation, was inhibited after treatment  with apelin-13. These effects correlatedwith  upregulation of the antioxidant catalase  (Day et al. 2013).  Chen et al. (2014) have added an important  contribution by investigating the role of  histone acetylation in apelin-induced effects  on the diabetic kidney. Experiments carried  out by these investigators demonstrated  that apelin-13 inhibits histone hyperacetylation  induced by either diabetes  in the Akita mouse or high glucose  concentration in cultured mesangial cells.  This effect is mediated by selective  upregulation of the expression of histone  deacetylase HDAC1 (Chen et al. 2014). It  is known that histone acetylation levels are  regulated through the opposing activities of  histone acetyltransferases and deacetylases,  and that histone acetylation?deacetylation  equilibrium plays a critical role in  the control of gene expression. The  participation of histone acetylation in the  pathophysiology of diabetic nephropathy is  still not well understood. As Chen et al.  (2014) explain in their article (see their  Discussion), previous studies demonstrated  that histone hyperacetylation induces  overexpression of inflammation-associated  genes; and on the contrary, evidence has  been accumulating that HDAC inhibitors  exert renoprotective effects on the diabetic  kidney. These controversies remain to  be resolved. Probably, the identification  of the individual transacetylase\/deacetylase  enzyme isoforminvolved in each case could  contribute to elucidation of this issue.  In the studies performed by Chen et  al. (2014), the levels of two HDACs  (HDAC1 and HDAC2) and two histone  acetyltransferases (PCAF and GCN5) were  determined. The expression level of only  HDAC1 was affected by apelin-13 treatment  in Akita mouse kidneys. In parallel with  the diminution in histone acetylation  levels, apelin-13 significantly reduced the  diabetes-induced increase in renal monocyte  chemotactic protein 1, intercellular  adhesion molecule 1, inducible nitric oxide  synthase and p65 [the active form of the  transcriptional subunit of nuclear factor-&#954;B  (NF-&#954;B)] phosphorylation levels of Akita  mice (Chen et al. 2014). Interestingly,  Ashburner et al. (2001) demonstrated  that HDAC1 expression represses tumour  necrosis factor-induced NF-&#954;B-dependent  gene expression. Consistent with this, the  authors showed a direct association of  HDAC1 with the Rel homology domain  of p65. In diabetic nephropathy, an  increase in the NF-&#954;B p65 subunit and  NF-&#954;B?DNA binding depends on Toll-like  receptor protein 2 (TLR2) upregulation  (Mudaliar et al. 2013). In this connection,  trichostatin A, a histone deacetylase  inhibitor, upregulates the expression of both  TLR2 mRNA and protein in the human  THP-1 cell line (Li et al. 2013). Taking  this information into account, it could  be interesting to investigate whether the  apelin-induced anti-inflammatory effects in  diabetic nephropathy aremediated by direct  association of the increasedHDAC with p65  and\/or TLR2 downregulation.  In summary, the recently described effects  of apelin on whole-body metabolism (for  review see Castan-Laurell et al. 2011) and,  especially, on the diabetic kidney (Day et al.  2013; Chen et al. 2014) lead to the proposal  that apelin may be a novel therapeutic  tool for treatment of diabetic nephropathy.  The investigation by Chen et al. (2014)  showed that apelin-13 alters the histone  acetylation?deacetylation balance, exposing  a wide spectrum of potential targets for  the beneficial effects of this adipokine  on diabetes-induced renal injury. Further  investigations focused on elucidation of  these mechanisms could contribute to  evaluation of the risk?benefit ratio of  apelin-13 treatment.","palabras_clave":"APELIN|DIABETES|NEPHROPATHY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34562,"idioma_id":5,"titulo":"Memorias militantes durante la década del 70 en Bahía Blanca, Argentina.","resumen":"A partir del presente trabajo nos proponemos abordar determinadas experiencias de militancia en la ciudad de Bahía Blanca, Argentina, durante la década setenta. Partiendo de una perspectiva etnográfica, destacamos la centralidad de los discursos nativos en el proceso de construcción de las memorias presentes sobre dicho pasado. De aquí se desprenden una serie de preguntas que guían gran parte de nuestra búsqueda: cómo se relacionaron las experiencias de vida cotidiana y la militancia con procesos histórico-políticos más amplios, cómo se insertaba la militancia y la política en la vida de un sujeto y cómo hoy se reconstruyen esas experiencias.","palabras_clave":"Memoria|Militancia|Años 70|Bahía Blanca"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34564,"idioma_id":4,"titulo":"?Piedra Mar del Plata?:  An Argentine orthoquartzite worthy of being considered as a 'Global Heritage Stone Resource'","resumen":"Although Argentina is a large country only a few local stones meet the requirements to be used for construction purposes. Piedra Mar del Plata is a quartzite that has been used for more than 50 years mainly as a building stone. During the 1930s and 1950s, its use in the construction of houses in the city of Mar del Plata (a famous beach resort) created a distinctive architectural style. Because of its durability and availability the use of this stone rapidly spread in other parts of the country.  Sculptures and monuments have been also been made out of this stone. Mar del Plata architectural style is now part of the heritage of Argentina and represents the rise of the middle class, when local citizens could afford to build their own houses rather than mansions which were constructed by rich families with imported stone.","palabras_clave":"GLOBAL STONE|QUARTZITE|MAR DEL PLATA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34593,"idioma_id":5,"titulo":"Trabajo y Moralidad en el marco de relaciones de producción capitalistas. Elementos para pensar las relaciones laborales desde la sociología clásica","resumen":"El Trabajo como praxis ha sido ubicado, en el contexto de la modernidad, en la esfera de ?lo económico?, pero los discursos que lo construyen como problema tienden a revestirlo con una serie de elementos normativos y valoraciones que no se condicen con las condiciones estructurales y las ?reglas de juego? propias del mercado de trabajo del sistema capitalista.  Reconstruiremos aquí algunos núcleos teóricos de abordaje de la relación entre Trabajo y Cultura en términos de Moral en el marco de una regulación capitalista de las relaciones de producción. Para esto recuperaremos fragmentos de la teoría de la solidaridad social de Emile Durkheim y su relectura en la obra de Jürgen Habermas.  A partir de estas discusiones plantearemos posibles líneas de análisis en torno a las necesidades sistémicas de articulación de esferas diferenciadas como las del Trabajo y la Moral, en un mundo del trabajo instrumentalizado y fragmentado. Por último, discutiremos la necesidad de conceptualizar la relación Trabajo ? Moralidad, al mismo tiempo, en términos de solidaridad y disputa.","palabras_clave":"trabajo|moralidad|sociología del trabajo|racionalización"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34612,"idioma_id":5,"titulo":"?La educación prohibida: ¿desafío a la forma escolar o propuesta educativa funcional a un capitalismo soft??.","resumen":"La ?forma escolar? tradicional ha sido cuestionada en reiteradas oportunidades y desde ángulos diferentes. En el presente artículo nos concentraremos en el análisis de algunas críticas que, presentándose como alternativas libertarias y superadoras de la misma, acaban resultando funcionales a la nueva configuración adquirida por el capitalismo en la actualidad. De este modo, sostenemos que discursos educativos apologéticos del auti-autoritarismo, la flexibilidad, la creatividad y la autonomía entendida como la libertad de cada uno para darse las propias normas resultan afines a cierto modo de gestión empresarial en el marco de un nuevo espíritu del capitalismo en el que crece la importancia de la responsabilizacion individual por los propios actos y se acentúan procesos de individuación.  En ese sentido, en el presente ensayo analizaremos la película- documental ?La educación prohibida?, estrenada en agosto de 2012, en la cual se critica a la escolarización estatal obligatoria abogando por el fin de la ?forma escolar? tradicional.   En la primera parte del escrito desplegaremos los conceptos de ?forma?, ?gramática?, ?cultura escolar? y ?Programa Institucional? colocándolos en función del análisis de la película. En la segunda, presentaremos y analizaremos críticamente algunos de los cuestionamientos al monopolio estatal de la educación formal que el documental esgrime, sosteniendo que los mismos presentan afinidad electiva con la actual configuración de un capitalismo soft.","palabras_clave":"forma escolar tradicional|- propuestas alternativas|- capitalismo soft-  |- procesos de individuación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34631,"idioma_id":4,"titulo":"Multi-Period Design and Planning of Closed-Loop Supply Chains with Uncertain Supply and Demand","resumen":"A design and planning approach is proposed for addressing general multi-period, multi-product closed-loop supply chains (CLSCs), structured as a 10-layer network (5 forward plus 5 reverse flows), withuncertain levels in the amount of raw material supplies and customer demands. The consideration ofa multi-period setting leads to a multi-stage stochastic programming problem, which is handled by amixed-integer linear programming (MILP) formulation. The effects of uncertain demand and supply onthe network are considered by means of multiple scenarios, whose occurrence probabilities are assumedto be known. Several realistic supply chain requirements are taken into account, such as those relatedto the operational and environmental costs of different transportation modes, as well as capacity limitson production, distribution and storage. Moreover, multiple products are considered, which are groupedaccording to their recovery grade. The objective function minimizes the expected cost (that includes facil-ities, purchasing, storage, transport and emissions costs) minus the expected revenue due to the amountof products returned, from repairing and decomposition centers to the forward network. Finally, com-putational results are discussed and analyzed in order to demonstrate the effectiveness of the proposedapproach. Due to the large size of the addressed optimization problem containing all possible scenariosfor the two uncertain parameters, scenario reduction algorithms are applied to generate a representative,albeit smaller, subset of scenarios.","palabras_clave":"Supply Chain|MILP |Uncertainty|Closed-Loop SC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34649,"idioma_id":4,"titulo":"Hydrogen reservoirs, an ab-initio study on saline hydrides based on Li\/Be-H compounds","resumen":"Research into new materials to be used as hydrogen reservoirs is necessary, the increasing demand of energy in the world should be covered progressively by clean energies, trying not to pollute the environment. With this work we wish to contribute to the knowledge of the different saline hydrides and the possibility of using these as hydrogen reservoirs. We performed a systematic study on these materials. In this work we used different ab-initio codes to study several compounds of lithium and beryllium with hydrogen.","palabras_clave":"SOLID STATE|MATERIALS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34748,"idioma_id":5,"titulo":"Devaluación y restricción externa. Los dilemas de la coyuntura económica actual","resumen":"Este trabajo se inscribe en un escenario caracterizado por la irrupción de la crisis mundial y la intensificación de las pugnas sociales y políticas en la economía argentina a partir de 2008, que derivaron en un cambio en el desenvolvimiento de distintas variables económicas y la emergencia de la ?restricción externa? con sus consiguientes efectos en el ciclo del crecimiento. En ese marco, el objetivo de este artículo consiste en evaluar las características del proceso económico que culminó en la devaluación del tipo de cambio en enero de 2014, procurando identificar las causas -estructurales y coyunturales- que incidieron en la implementación de esta medida. Dado que el nudo de los problemas se expresó en el estrangulamiento del sector externo, las diversas indagaciones contribuyen, también, a interpretar las particularidades de este fenómeno en la actualidad.","palabras_clave":"RESTRICCION EXTERNA|DEVALUACION|POSCONVERTIBILIDAD|ECONOMIA ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34839,"idioma_id":4,"titulo":"Computer-aided design of bromelain and papain covalent immobilization.","resumen":"Enzymes as immobilized  derivatives have been widely used in Food, Agrochemical, Pharmaceutical and  Biotechnological industries. Protein immobilization is probably the most used  technology to improve the operational stability of these molecules. Bromelain (Ananas comosus) and papain (Carica papaya) are cystein proteases extensively used  as immobilized biocatalyst with several applications in therapeutics, racemic  mixtures resolution, affinity chromatography and others industrial scenarios.  The aim of this work was to optimize the covalent immobilization of bromelain  and papain via rational design of immobilized derivatives strategy (RDID) and RDID1.0 program. Were  determined the maximum protein quantity to immobilize, the optimum  immobilization pH (in terms of functional activity retention), was predicted  the most probable configuration of the immobilized derivative and the  probabilities of multipoint covalent attachment. As support material was used Glyoxyl-Sepharose  CL 4B. &nbsp;The accuracy of RDID1.0 program´s prediction  was demonstrated comparing with experimental results. Bromelain and papain immobilized derivatives showed  desired characteristics for industrial biocatalysis, such as: elevate pH  stability retaining 95% and 100% residual activity at pH 7.0 and 8.0, for bromelain  and papain, respectively; high thermal stability at 30 °C retaining 90%  residual activity for both immobilized enzymes; a catalytic configuration  bonded by immobilization at optimal pH; and the ligand load achieve ensure the  minimization of diffusional restrictions.","palabras_clave":"bromelain|covalent immobilization|immobilized derivatives|papain|rational design"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34844,"idioma_id":5,"titulo":"El sentido fisiológico de la belleza: Mariano Barrenechea y la estética de Nietzsche","resumen":"Este artículo tiene por objetivo general la profundización de nuestro conocimiento sobre la influencia nietzscheana en el pensamiento estético-musical de Mariano Antonio Barrenechea (1884-1949), mediante un análisis de sus desarrollos en torno al 'valor biológico' de la belleza y a la naturaleza peculiar de lo 'bello-musical'. Dicho análisis se ejecuta en tres momentos diferentes en su obra Historia estética de la música (1918). En primer lugar, la investigación se centra en el comienzo de la argumentación estética de Barrenechea, vertebrada a partir de un fragmento póstumo de Nietzsche en el que se fundamenta la necesidad de superar una estética meramente receptiva o 'femenina'. Como segunda instancia del análisis, la investigación se detiene en la 'reducción de los juicios estéticos a postulados biológicos', operada por Barrenechea en un intento por imitar la metodología nietzscheana desplegada en el tercer libro de Der Wille zur Macht, 'La voluntad de poder como arte'. Finalmente, el tercer momento del análisis corresponde a una puesta en paralelo de las conclusiones de Barrenechea acerca del sentido fisiológico de la belleza con las nociones nietzscheanas de 'transfiguración' y 'afirmación'. En el transcurso del trabajo cobran relieve no sólo las presencias de Nietzsche, unas veces manifiestas y otras un tanto eclipsadas, sino también las ausencias, es decir, la omisión probablemente deliberada de determinados conceptos.","palabras_clave":"ESTÉTICA|BELLEZA|BARRENECHEA|NIETZSCHEANISMO|RECEPCIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34858,"idioma_id":5,"titulo":"Caracterización ampelográfica de  variedades de Vitis vinífera cultivadas en Mendoza (Argentina), según el método de la OIV","resumen":"En el marco de un convenio realizado entre el Instituto Nacional de Semillas y la Cátedra de Viticultura de la Facultad de Ciencias Agrarias, perteneciente a la Universidad Nacional de Cuyo, se realizó la descripción ampelográfica e inscripción de 24 cultivares de vid difundidos en la Argentina que no se encontraban inscriptos en el Registro Nacional de Cultivares. A su vez, se describieron ampelográficamente 38 cultivares inscriptos en dicho registro, que no contaban aún con su correspondiente descripción.La observación de las variedades se realizó en las Colecciones Ampelográficas del INTA y de la Facultad de Ciencias Agrarias. Los descriptores utilizados, en un total de 54 por variedad, son los exigidos por el Instituto Nacional de Semillas. El trabajo se acompañó de fotografías digitales de brote, pámpano, hoja adulta, racimo y bayas.","palabras_clave":"VID|AMPELOGRAFIA|DESCRIPTORES|OIV"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34882,"idioma_id":4,"titulo":"Quinoid Compounds Cause Inhibition of Falcipain 2, and Arrest Plasmodium falciparum Growth in Vitro","resumen":"Nine quinone derivatives, three 2-hydroxy-1,4-naphthoquinone; three 4,5 and three 4,9-naphthoquinone scaffolds, were synthesized and evaluated against 3D7 and Dd2 Plasmodium falciparum strains. Quinoid compounds showed half-maximal inhibitory concentration (IC50) values in the micromolar range, and moderate toxicity against a human fibroblast cell line.&nbsp;&nbsp;&nbsp; Additionally, the compounds produced morphological changes in the digestive vacuole of treated parasites, similar to those caused by protease inhibitors that block hemoglobin degradation pathway, which is essential for parasite development. 2-hydroxy-3-(1-propenyl)-1,4-naphthoquinone (1) showed an IC50 value of 0.068 ± 0.035 &#956;M against FP2, a chemotherapeutic target, and thus representing a lead compound for further structure\/activity optimization. Taken together, our results suggest that blocking of hemoglobin degradation pathway by inhibiting the cysteine peptidases present in the digestive vacuole, could represent one of the mechanisms used by these compounds to antagonize the growth of malaria parasites.","palabras_clave":"Antimalarial agents|Falcipain 2 inhibition|Plasmodium falciparum|Quinoid derivatives"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34904,"idioma_id":4,"titulo":"Draft Genome Sequence of Bacillus thuringiensis Serovar Tolworthi Strain Na205-3, an Isolate Toxic for Helicoverpa armigera","resumen":"We report here the complete annotated 6,510,053-bp draft genome sequence of Bacillus thuringiensis serovar tolworthi strain Na205-3, which is toxic for Helicoverpa armigera. This strain potentially contains nine insecticidal toxin genes homologous to cry1Aa12, cry1Ab1, cry1Ab8, cry1Ba1, cry1Af1, cry1Ia10, vip1Bb1, vip2Ba2, and vip3Aa6.","palabras_clave":"BACILLUS THURINGIENSIS|GENOME SEQUENCING|INSECTICIDAL PROTEINS|BIOLOGICAL CONTROL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34913,"idioma_id":5,"titulo":"Reseña del Audiovisual Argenmex","resumen":"En el audiovisual Argenmex se reflexiona sobre la construcción identitaria de la generación de hijos de exiliados políticos expulsados por la última dictadura cívico-militar argentina (1976-1983), es decir aquellos hijos de padres argentinos que han nacido y\/o crecido en México y que, al momento de realizar el audiovisual (2007) tienen entre 25 y 30 años aproximadamente. La atención gira en torno a una cena realizada en una casa argentina con comida mexicana entre siete participantes. Se intercambian miradas, opiniones, historias de vida al mismo tiempo que, en un proceso activo, se (re)construyen los relatos de cada protagonista. A su vez, también se suman posteriormente otras historias de hijos de exiliados, ampliando la geografía del exilio hacia otros países y mostrando al colectivo organizado en ?Hijas e Hijos del Exilio? (HdEx).","palabras_clave":"AUDIOVISUAL|ARGENMEX|IDENTIDAD|EXILIO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34919,"idioma_id":4,"titulo":"Litter and soil properties are not altered by invasive deer browsing in northern Patagonia forests.","resumen":"        It is largely accepted that large mammalian herbivores can indirectly  influence ecosystem properties by changing the quantity and quality of litter  inputs to soil through selective browsing on plant communities. However,  idiosyncratic effects (positive, neutral and negative) have been found for  different vegetation types, herbivory and soil properties. In this study we  tested whether browsing by exotic deer introduced into Patagonian forests 90  years ago alters physical, chemical and biological soil properties and litter  quantity and quality. As in many terrestrial ecosystems, N is the main nutrient  that limits plant growth in Patagonia. Consequently, any disturbance that  alters the N cycle, such as changes in the type or intensity of herbivory, is  expected to affect these forest ecosystems. We compared soil and total litter  from inside and outside five 7-yr old exclosures located on Isla Victoria,  Parque Nacional Nahuel Huapi, Argentina. Despite introduced deer has significantly  affected the composition, abundance and structure of the understory vegetation,  we found no differences between browsed and unbrowsed areas in the physical  (bulk density, moisture), chemical (pH, base cations, organic C and total N)  and biological (potential microbial respiration and net N mineralization) soil properties.  This could be attributable to the high capacity of volcanic soils to stabilize  organic matter, buffering disturbance-induced changes. However, the quantity  and quality (C, N and C\/N ratio) of total litter were also not different between  browsed and unbrowsed areas. Although non-significant differences were found  between treatments in both compartments, litter and soil, most variables showed  a slight trend towards higher values in unbrowsed  areas. This suggests that 7 years of browsing exclusion would be not enough to detect changes induced by browsing,  particularly in highly stable volcanic soils.  ","palabras_clave":"Temperate forest|Volcanic soils|Total litter|Exotic herbivores|Red deer|Fallow deer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34954,"idioma_id":5,"titulo":"El sitio Mariscal (SSalCac 5): investigaciones sobre la vida cotidiana de una aldea prehispánica de Valle Calchaquí Norte","resumen":"Se presentan los primeros resultados de los trabajos de excavación y relevamiento arquitectónico realizados en el sitio Mariscal (SSalCac 5) como parte del proyecto de investigación ?Percepción y experiencias en las aldeas prehispánicas del valle Calchaquí Norte (Salta): Arqueología  de la vida cotidiana, prácticas y relaciones sociales durante el Período Prehispánico Tardío?, dirigido por el Dr. Félix Acuto. Mariscal es un sitio conglomerado que fue ocupado durante momentos tardíos (900-1470 DC), está emplazado sobre la margen izquierda del río Cachi, en las inmediaciones del actual poblado de Cachi (departamento de Cachi, Salta). A través de los estudios que se vienen efectuando en él desde el año 2006, nuestro equipo de investigación ha ahondado en las formas de organización del espacio y circulación interna del sitio, la coexistencia con estructuras funerarias, la distribución de la cultura material y su  relación con la vida en el pasado.","palabras_clave":"NOA|PERIODO TARDIO|HOMOGENEIDAD MATERIAL|VIDA COTIDIANA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":34994,"idioma_id":5,"titulo":"Aphanes arvensis (Rosaceae) en el extremo nordeste de la Argentina","resumen":"Se menciona por primera vez para el nordeste argentino a una hierba adventicia en el nuevomundo. La especie es ilustrada mediante fotografías","palabras_clave":"Flora argentina|hierba|plantas adventicias|Misiones"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35022,"idioma_id":5,"titulo":"RECONSTRUCCION TOMOGRAFICA GUIADA POR ECUACIONES DE TRANSPORTE","resumen":"        En este  trabajo se propone utilizar el algoritmo Metrópolis Monte Carlo para generar reconstrucciones  tomográficas a partir de pocas proyecciones, incorporando además información a priori  acerca de la textura del objeto a reconstruir. La información a priori se  introduce por medio de una función de energía local la cual se suma a la  función de error respecto de las proyecciones. A diferencia de la función de  información a priori utilizada tradicionalmente para filtrado de bordes, se introduce  un control adaptativo del filtro durante el proceso de reconstrucción. El  método fue probado con imágenes sintéticas como también en la reconstrucción de  un objeto real a partir de un número muy limitado de proyecciones ruidosas  obtenidas con una fuente Plasma Focus. En la reconstrucción de imágenes con  regiones homogéneas, la técnica muestra buenos resultados, lo cual resulta  altamente aplicable para ensayo no destructivo de materiales industriales, como  también en la detección de formas o zonas específicas en imágenes médicas.  ","palabras_clave":"Procesamiento de imágenes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35055,"idioma_id":5,"titulo":"El Instituto Nacional de Vitivinicultura: el regulador creado, intervenido y reformado","resumen":"El Instituto Nacional de Vitivinicultura (INV) fue creado en 1959 por ley nacional N° 14.878, que constituyó una política pública clave para el desarrollo de la vitivinicultura nacional, en tanto cristalizó una determinada correlación de fuerzas existente en la época de creación e influyó en los conflictos y la evolución de esta agroindustria en los años posteriores.  El texto de la ley permitía avizorar los enfrentamientos que se producirían en los años siguientes. La forma colegiada y con representación pública y privada establecida para la conducción del organismo, fue rápidamente suspendida y en su reemplazo, el Instituto fue intervenido por el gobierno nacional por 21 años. Gobiernos democráticos y dictatoriales decidieron dirigir el organismo a través de sus delegados limitando el cumplimiento de la ley.  La historia de las intervenciones demuestra cómo un mismo instrumento puede servir para diversos fines. Etapas de énfasis en el control contra la adulteración y de creación de políticas activas se alternaron con tiempos de parálisis y desfinanciación del Instituto.  Luego de un año del retorno a la democracia en el país, en 1.984, el INV normalizó su conducción, retornado a la forma colegiada y mixta en un momento de profunda crisis de la agroindustria vitivinícola.  El estudio de las políticas públicas y de las instituciones estatales es un campo promisorio para el análisis politológico, porque allí se establecen relaciones de poder y se disputan recursos. Las decisiones surgidas en los órganos reguladores de las agroindustrias no son simplemente técnicas, porque tienen efectos políticos y económicos que impactan en actores concretos.  El presente artículo reseña la historia del INV desde su creación hasta 1991, año en que, a través del Decreto de Desregulación Económica N° 2.284, el Poder Ejecutivo Nacional (PEN) decidió una profunda reforma en la forma de conducción y en las funciones del Instituto","palabras_clave":"VITIVINICULTURA|POLÍTICAS|INSTITUTO|INTERVENCIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35080,"idioma_id":4,"titulo":"Draft Genome Sequences of Two Bacillus thuringiensis Strains and Characterization of a Putative 41.9-kDa Insecticidal Toxin","resumen":"In this work, we report the genome sequencing of two Bacillus thuringiensis strains using Illumina next-generation sequencing technology (NGS). Strain Hu4-2, toxic to many lepidopteran pest species and to some mosquitoes, encoded genes for two insecticidal crystal (Cry) proteins, cry1Ia and cry9Ea, and a vegetative insecticidal protein (Vip) gene, vip3Ca2. Strain Leapi01 contained genes coding for seven Cry proteins (cry1Aa, cry1Ca, cry1Da, cry2Ab, cry9Ea and two cry1Ia gene variants) and a vip3 gene (vip3Aa10). A putative novel insecticidal protein gene 1143 bp long was found in both strains, whose sequences exhibited 100% nucleotide identity. The predicted protein showed 57 and 100% pairwise identity to protein sequence 72 from a patented Bt strain (US8318900) and to a putative 41.9-kDa insecticidal toxin from Bacillus cereus, respectively. The 41.9-kDa protein, containing a C-terminal 6× HisTag fusion, was expressed in Escherichia coli and tested for the first time against four lepidopteran species (Mamestra brassicae, Ostrinia nubilalis, Spodoptera frugiperda and S. littoralis) and the green-peach aphid Myzus persicae at doses as high as 4.8 µg\/cm2 and 1.5 mg\/mL, respectively. At these protein concentrations, the recombinant 41.9-kDa protein caused no mortality or symptoms of impaired growth against any of the insects tested, suggesting that these species are outside the protein?s target range or that the protein may not, in fact, be toxic. While the use of the polymerase chain reaction has allowed a significant increase in the number of Bt insecticidal genes characterized to date, novel NGS technologies promise a much faster, cheaper and efficient screening of Bt pesticidal proteins","palabras_clave":"BACILLUS THURINGIENSIS|GENOME SEQUENCING|INSECTICIDAL PROTEINS|BIOLOGICAL CONTROL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35134,"idioma_id":5,"titulo":"Alasitas: mito, tradicion y modernidad","resumen":"La diversificación de clase de la comunidad andina en Buenos Aires suele quedar invisibilizada bajo la aglutinante clasificación de ?boliviano? asociada a la miseria económica y cultural. A partir del análisis de la fiesta popular Alasitas. En el articulo se da cuenta de los cambios generacionales y las nuevas perspectivas de los hijos, hoy ciudadanos argentinos. Mientras muchos viven en una situación de pobreza, también existen las elites económicas, grupos universitarios, y sectores productivos.","palabras_clave":"ALASITAS|EKEKO|MINIATURAS|RITUAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35170,"idioma_id":5,"titulo":"El actor cuentista popular: una aproximación al estudio de sus procedimientos","resumen":"Al momento de realizar una diferenciación entre el actor dramático- actor cómico (popular), Pellettieri (2001) establece que tal distinción, entre otras, se produce a partir del lenguaje utilizado y el estrato social del público a quien se dirigen. En el caso del actor dramático, su lenguaje y su público destinatario es culto, a diferencia del actor nacional que utiliza un lenguaje popular y su público destinatario es la clase media baja. En la actualidad, observamos que tal delimitación en el caso de los actores ?cuentistas? populares se presenta de manera más porosa, en especial si tomamos como objeto de análisis su lenguaje, su relato, su modo de ?decir? y al público al cual se dirigen. A tales efectos, y con el fin de realizar un aporte a los estudios de la actuación popular en la Argentina, en el presente trabajo profundizaremos en la contraposición de dos casos que creemos paradigmáticos para dar cuenta de tal variación,  a partir del análisis de los procedimientos y las técnicas que son utilizados por Juan Verdaguer (1915-2001) y Luis Landriscina (1935) en sus roles de cuentistas.","palabras_clave":"actor popular|cuentista|público|privado"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35176,"idioma_id":5,"titulo":"Una ciencia espectral. Sobre Informe sobre ectoplasma animal, de Roque Larraquy y Diego Ontiveros","resumen":"Reseña de 'Informe sobre ctoplasma animal', de Roque Larraquy y Diego Ontivero.","palabras_clave":"Larraquy|Ontivero|Literatura argentina|Ciencia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35205,"idioma_id":4,"titulo":"Preliminary results of corrosion monitoring studies of carbon steel overpack exposed to supercontainer concrete buffer","resumen":"The supercontainer (SC) is the reference concept for the postconditioning of vitrified high level radioactive waste and spent fuel in Belgium. It is designed with a concrete buffer completely surrounding a carbon steel overpack. A half-scale (HST-2) experiment was set up to measure the instantaneous uniform corrosion rate, representative of the initial oxic phase, in situ. The test setup has the same diameter as a full size SC, but it is limited in height to approximately half of a real SC. The corrosion rate of carbon steel is measured in four ways: weight loss measurements (carbon steel coupons), corrosion sensor based on linear polarisation resistance, corrosion sensor based on multisine electrochemical impedance spectroscopy and corrosion sensor based on single sine electrochemical impedance spectroscopy coupled to a unique analytical method. This paper presents the preliminary results of the corrosion rates measured with these independent methods.","palabras_clave":"UNIFORM CORROSION|PASSIVE|CONCRETE|STEEL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35218,"idioma_id":5,"titulo":"De San Petersburgo a San Pedro del Atuel: aproximación a la biografía del compositor Alejo Abutcov","resumen":"El presente artículo presenta la biografía del compositor ruso Alejo Vladimir Abutcov (1872-1945), quien se instaló en 1924 en la localidad de San Pedro del Atuel (Mendoza, Argentina) con el objetivo de formar una colonia tolstoiana. Abutcov se convirtió en el pionero de la enseñanza musical institucionalizada en el sur de la provincia de Mendoza al crear en la ciudad de General Alvear el Conservatorio ?Schubert?, en 1928. Se presenta, asimismo, el catálogo parcial de sus obras de acuerdo con los datos obtenidos en diversas fuentes.","palabras_clave":"Catálogo musical|Obras musicales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35226,"idioma_id":5,"titulo":"Las cantoras de Malargüe","resumen":"Los estudios sobre la música tradicional en la provincia de Mendoza se han llevado a cabo, generalmente, siguiendo los modelos en boga de fines del siglo XIX y la primera mitad del siglo XX. Los folkloristas más renombrados de esta zona, como Alberto Rodríguez, Juan Draghi Lucero, Jorge Segura, entre otros, se convirtieron en su momento en los ?guardianes de la tradición? (Díaz Viana, 2002). Al ser establecidos por estos folkloristas los criterios de autenticidad y los parámetros a través de los cuales se determinó, generalmente de manera arbitraria, cuál era la música representativa de Mendoza y de la región cuyana, las manifestaciones musicales que no se encuadraban dentro de estos cánones fueron ignoradas por los recopiladores y los estudiosos. Este es el caso de una tradición presente en el sudoeste del departamento de Malargüe, el más austral de la provincia de Mendoza: las denominadas ?cantoras de Malargüe?.","palabras_clave":"Malargüe (Mendoza)|Cantoras|Folklore|Etnomusicología"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35229,"idioma_id":5,"titulo":"Análisis Neotectónico del Sistema de Falla La Cantera, Precordillera Central, San Juan, Argentina. Su evaluación como fuente sismogénica potencia","resumen":"El Sistema de Falla La Cantera (SFLC) es una de las principales estructuras activas en elámbito de la Precordillera Central de San Juan, centro-oeste de Argentina, que se extiende por 47 km a lo largo del valle que separa las sierras de La Cantera y La Invernada, al norte del río San Juan. La orientación promedio de las fallas es N20ºE y buzan al oeste entre 15º y 30º en el tramo norte, aproximadamente 40º O en el tramo central y hasta 60º O en el extremo sur. La estructura es fundamentalmente un cabalgamiento que deforma y desplaza todos los niveles de abanicos aluviales del Pleistoceno y Holoceno pertenecientes al piedemonte occidental de la sierra de La Cantera y está definida por una serie de geoformas típicas de fallamiento activo de carácter compresivo, entre las que se destacan escarpes de falla a contrapendiente, simples y compuestos, escarpes flexurales, terrazas fluviales escalonadas, lagunas de falla, fuentes alineadas, redes en rastrillo, cauces desplazados, obturados, colgados y con diferentes grados de incisión. Se presentan así, evidencias sobre la reactivación cuaternaria tardía del SFLC, un cabalgamiento de vergencia oriental, enlazando los episodios tectónicos con las modificaciones del paisaje. A lo largo de todo su trazado se identificaron y analizaron numerosas trincheras naturales, y tres de ellas fueron analizadas. En ellas se pudo observar cómo la falla corta los depósitos holocenos en el extremo norte, mientras que hacia el sur afecta a niveles más antiguos, constituyendo un cabalgamiento ciego. En las trincheras seleccionadas en el tramo norte y central se identificaron dos cuñas coluviales que permitieron interpretar en forma preliminar dos eventos sísmicos durante el Holoceno para el sector, mientras que en el tramo sur, sólo fue posible reconocer una cuña coluvial, relacionada con un evento sísmico. Sobre la base de las características y parámetros geomorfológicos, estratigráficos y estructurales analizados, se considera al SFLC como una fuente sismogénica de importancia para la ciudad de San Juan (&gt; 700.000 habitantes), y para los tres embalses construidos a lo largo del río San Juan (a 10, 35 y 40 km de distancia del SFLC).","palabras_clave":"MORFOTECTONICA|PALEOSISMICIDAD|CABALGAMIENTO|PRECORDILLERA CENTRAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35233,"idioma_id":4,"titulo":"Geodynamic Processes in the Andes of Central Chile and Argentina. Geological Society, London,","resumen":"The piedmont of Cordillera Frontal between c. 338 and 348S (Mendoza, Argentina) is ahighly populated area deeply modified by human activities, known as Valle de Uco. It is situatedwithin the borderland region of the geological provinces of Cordillera Frontal and Cuyo basin. Thelandscape is dominantly composed of both erosional and depositional landforms made of fluvioaeoliandeposits fractured and folded by tectonic processes together with some landforms of volcanicorigin. Alluvial fans, related to several aggradational cycles of Quaternary age, are the mostremarkable geomorphological units. Several tectonic features are present giving rise to conspicuousmorphological features. Some of the streams are structurally controlled by faults while severaldrainage anomalies that indicate active tectonic processes have been identified. The Late Quaternaryalluvial sequences, dominantly comprising sandy and silty deposits of volcaniclastic compositionand secondarily metamorphic rocks, represent the fine-grained sedimentary facies of thefluvial systems accumulated in a distal fan environment. The alluvial deposits have been incisedby several episodes of erosion since Pleistocene time.","palabras_clave":"QUATERNARY|PIEDMONT|MENDOZA|CLIMATE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35273,"idioma_id":4,"titulo":"Molecular and Insecticidal Characterization of a Novel Cry-Related Protein from Bacillus Thuringiensis Toxic against Myzus persicae","resumen":"This study describes the insecticidal activity of a novel Bacillus thuringiensis Cry-related protein with a deduced 799 amino acid sequence (~89 kDa) and ~19% pairwise identity to the 95-kDa-aphidicidal protein (sequence number 204) from patent US 8318900 and ~40% pairwise identity to the cancer cell killing Cry proteins (parasporins Cry41Ab1 and Cry41Aa1), respectively. This novel Cry-related protein contained the five conserved amino acid blocks and the three conserved domains commonly found in 3-domain Cry proteins. The protein exhibited toxic activity against the green peach aphid, Myzus persicae (Sulzer) (Homoptera: Aphididae) with the lowest mean lethal concentration (LC50 = 32.7 &#956;g\/mL) reported to date for a given Cry protein and this insect species, whereas it had no lethal toxicity against the Lepidoptera of the family Noctuidae Helicoverpa armigera (Hübner), Mamestra brassicae (L.), Spodoptera exigua (Hübner), S. frugiperda (J.E. Smith) and S. littoralis (Boisduval), at concentrations as high as ~3.5 &#956;g\/cm2. This novel Cry-related protein may become a promising environmentally friendly tool for the biological control of M. persicae and possibly also for other sap sucking insect pests.","palabras_clave":"BACILLUS THURINGIENSIS|DELTA-ENDOTOXINS|CRY-RELATED PROTEIN|PARASPORIN|GREEN-PEACH APHID|MYZUS PERSICAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35288,"idioma_id":4,"titulo":"Bacillus thuringiensis Toxins: An Overview of Their Biocidal Activity","resumen":"Bacillus thuringiensis (Bt) is a Gram positive, spore-forming bacterium that synthesizes parasporal crystalline inclusions containing Cry and Cyt proteins, some of which are toxic against a wide range of insect orders, nematodes and human-cancer cells. These toxins have been successfully used as bioinsecticides against caterpillars, beetles, and flies, including mosquitoes and blackflies. Bt also synthesizes insecticidal proteins during the vegetative growth phase, which are subsequently secreted into the growth medium. These proteins are commonly known as vegetative insecticidal proteins (Vips) and hold insecticidal activity against lepidopteran, coleopteran and some homopteran pests. A less well characterized secretory protein with no amino acid similarity to Vip proteins has shown insecticidal activity against coleopteran pests and is termed Sip (secreted insecticidal protein). Bin-like and ETX_MTX2-family proteins (Pfam PF03318), which share amino acid similarities with mosquitocidal binary (Bin) and Mtx2 toxins, respectively, from Lysinibacillus sphaericus, are also produced by some Bt strains. In addition, vast numbers of Bt isolates naturally present in the soil and the phylloplane also synthesize crystal proteins whose biological activity is still unknown. In this review, we provide an  updated overview of the known active Bt toxins to date and discuss their activities.","palabras_clave":"BACILLUS THURINGIENSIS|INSECTICIDAL TOXINS|ENTOMOPATHOGENIC BACTERIA|PESTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35309,"idioma_id":5,"titulo":"PROYECTO DE EXTENSIÓN DE LA QUINTA A LA MESA","resumen":"Este es un proyecto de extensión de la Universidad Nacional de La Plata quecomenzó en el año 2012. Sus integrantes son profesionales y estudiantes dedistintas unidades académicas, integradas en una iniciativa que con un abordaje interdisciplinario han contribuido a su desarrollo.En los últimos años la existencia de kioscos saludables en escuelas de la ciudad de La Plata y alrededores ha sido una iniciativa que si bien posibilita poder ofrecer otro tipo de alimentos, necesita ser complementada con acciones de difusión y educación que permitan problematizar las prácticas de consumo habituales. Asimismo, las propuestas curriculares de las instituciones educativas de nivel básico, si bien abordan cuestiones relativas a los aspectos nutricionales relacionados al consumo de frutas y hortalizas, no integran esos desarrollos con aspectos sociales, económicos y ecológicos propios de una perspectiva integrada y compleja, tal como las que suscriben actualmente distintas corrientes asociadas a las prácticas de consumo responsable. En tal sentido, una redefinición del abordaje de estas temáticas permitiría a los estudiantes reconocer y problematizar situaciones que están conectadas con la realidad geográfica y socioeconómica en la que viven. Vale resaltar la importancia del Partido de La Plata en la producción hortícola de la región en la que se inserta el trabajo de la Universidad Nacional de La Plata. Como es sabido, esta región se integra a otras zonas muy importantes en nuestro país, en lo que respecta a la producción de frutas y hortalizas, las que se destinan en una alta proporción al mercado interno, y que son una fuerte generadora de empleos.Se ha trabajado en escuelas de la ciudad de La Plata con estudiantes de 5  año de la Educación Primaria Básica, en la educación y apropiación de conocimientos sobre hortalizas y frutas, profundizando el interés en los producidos en el Cinturón Hortícola Platense, abordándose distintos ejes temáticos, entre ellos los relacionados con el origen y las formas de producción de los cultivos, su oferta estacional, las etapas de comercialización, las propiedades nutritivas. El presente proyecto fue aprobado con financiamiento en las convocatorias de proyectos de extensión de la UNLP,  años 2011 y 2012.","palabras_clave":"consumo|responsable|educación|salud"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35313,"idioma_id":5,"titulo":"Huellas, herencias y tramas. La construcción de la identidad profesional del Profesor de Psicología","resumen":"Resumen.  El trabajo presenta  categorías conceptuales y estrategias metodológicas de la investigación de  Tesis Construcción de identidad de profesores de Psicología desde la perspectiva  de sus narrativas sobre la experiencia educativa. Se articulan indagaciones sobre la identidad  docente con Investigaciones Marco. Ejes centrales de debate en los Enfoques  Socioculturales: ¿identidad o identidades? , ¿construcción o imposición desde  centros de poder? , ¿universalidad o pluralidad?, ¿coherencia o pastiche?, re-significan  tensiones y condiciones de profesionalización de Psicólogos Egresados de  Universidad de Buenos Aires como Profesores en Psicología. La identidad aparece  como sedimento de huellas, legados y tramas subjetivo-situacionales e históricas,  mediante&nbsp; interiorización de selves  dialógicos, orquestación de voces y agencia reflexiva, vinculando modelos y  trayectorias en la formación docente. Pensamientos de Vygotsky, Mead, Erikson,  Bakhtin, son relevantes para analizar (de)construcciones de roles profesionales  y &nbsp;cambios contextuales. La narrativa  emerge, como escritura reelaborativa, produciendo nuevos sentidos y  significados de la experiencia en la memoria colectiva","palabras_clave":"IDENTIDAD|PROFESORES DE PSICOLOGÍA|NARRATIVAS|EXPERIENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35369,"idioma_id":10,"titulo":"Crisis del lenguaje y ocaso de la experiencia en Walter Benjamin y Siegfried Kracauer","resumen":"El artículo se propone examinar una serie de reflexiones sobre la crisis del lenguaje, en el marco general de una crisis de la experiencia en la Modernidad. Para ello, sugiere como punto de partida la tematización del problema en el viejo Goethe, y muestra luego la recuperación de este abordaje en la literatura del fin-de-siècle alemán y el austríaco. Se detiene a considerar la elaboración del problema en la obra ensayística de Walter Benjamin y en la producción narrativa de Siegfried Kracauer.","palabras_clave":"estética|teoría literaria|experiencia|lenguaje"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35400,"idioma_id":5,"titulo":"Nuevas lecturas críticas de Onetti después de Onetti","resumen":"P { margin-bottom: 0.21cm; }                Reseña bibliográfica sobre el libro  Onetti fuera de sí (Katatay,  2013), compilado por Teresa Basile y Enrique Foffani, donde se reúnen  estudios críticos sobre la obra del escritor uruguayo Juan Carlos  Onetti en el escenario de la  cultura latinoamericana. La singularidad de los trabajos reunidos  allí es la manifestación de un corrimiento de límites en relación  a las perspectivas y a los abordajes de análisis de la obra  literaria. El compromiso que este libro asume y logra realizar es  descanonizar las lecturas sobre el escritor uruguayo. Los estudios  críticos de Pollastri, Foffani, Basile, Linares y Calabrese, por  nombrar sólo algunos, abordan esta obra dejando de lado el canon y  las lecturas instituidas al proponer nuevos modos de ingresar a la  obra onettiana.","palabras_clave":"ONETTI|ESTUDIOS|CRITICOS|LITERATURA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35405,"idioma_id":5,"titulo":"Margo Glantz: La moda entre la escritura y la imagen","resumen":"p { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 0); }p.western { font-family: 'Times New Roman',serif; font-size: 12pt; }p.cjk { font-family: 'WenQuanYi Micro Hei'; font-size: 12pt; }p.ctl { font-family: 'Lohit Hindi'; font-size: 12pt; }      Este  artículo plantea un recorrido por los primeros escritos ficcionales  de Margo Glantz ?Las mil y una calorías. Novela dietética  (1978),  El día de tu boda (1982), La lengua en la mano  (1983), De la amorosa inclinación a enredarse en cabellos  (1984) y Erosiones (1984)? a la luz de la temática de la  moda. Focalizar en la tensión entre la escritura y la moda nos  permitió observar el rol que juega lo visual en estas composiciones.  Lo visual se convierte en un elemento constitutivo del relato ya que  fotos, postales, dibujos e ilustraciones se incorporan a la  producción literaria definiendo una práctica tan innovadora como  singular. Este artículo cierra con una entrevista  que le realicé a  Margo Glantz, donde  abordamos  principalmente  encuentros y tensiones entre la literatura y la temática  de la moda. Sus escritos  sobre el pelo en el periódico UnomásUno,  su participación en la revista Vogue,  su relación con el cine y la coexistencia de elementos textuales y  visuales son algunos de los asuntos abordados en relación a  distintos  momentos de su obra. ","palabras_clave":"MARGO |GLANTZ|LITERATURA|MODA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35406,"idioma_id":5,"titulo":"La persistencia del modelo de asistencia y promoción.","resumen":"El presente trabajo analiza la gestión de la asistencia en el Municipio de Rosario, Argentina, durante la última década y tiene por objetivo mostrar la persistencia del modelo de asistencia y promoción, sosteniendo como hipótesis general que los cambios acaecidos en la estructura social nacional y local en el pasado decenio no han sido acompañados por modificaciones sustanciales en la forma de concebir los problemas y en la consiguiente lógica de intervención social del Estado municipal.","palabras_clave":"ASISTENCIA|PROMOCIÓN|POBREZA|PROBLEMAS SOCIALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35413,"idioma_id":5,"titulo":"Del Estado Social al Estado Neoliberal: un nuevo pacto social en Nuestra América","resumen":"El presente trabajo se propone analizar el proceso de transición entre la desconversión del Estado Social y la posterior instauración y consolidación del Estado Neoliberal en Nuestra América, planteando que tal proceso marca un punto de inflexión que implica la construcción de un nuevo pacto social. Presenta, en primer lugar, una serie de criterios teórico-metodológicos a partir de los cuales se analizará dicho proceso. Caracteriza, luego, los rasgos centrales del acoplamiento entre Estado Social y Estado de Crecimiento, junto a las principales críticas que ese particular ensamblaje recibió hacia mediados de la década del setenta. Finalmente, aborda un conjunto de implicancias económicas, políticas, sociales y culturales intrínsecas a la consolidación del Estado Neoliberal, mostrando que efectivamente supuso la construcción de un nuevo pacto social.","palabras_clave":"ESTADO SOCIAL|ESTADO NEOLIBERAL|POLÍTICA SOCIAL|POBREZA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35416,"idioma_id":5,"titulo":"Influencia de las sales en las nanoestructuras de CMP","resumen":"Caseinomacropeptide (CMP) is a bioactive peptide obtained during the  cheese-making. The aim of this work was to analyze the influence of salts (NaCl  and CaCl2 in the formation ofCMP nano-structures by Dynamic Light Scattering (DLS). Due to high electrostatic repulsion, at pH  &#8805;  6.5 CMP is found in the monomeric form. However, the presence of salts (NaCl, CaCl2) promoted  CMP self-assembly to form dimers, tetramers, hexamers or more associated forms,  depending on the type and concentration of salt. These associated forms  self-assembled over time by electrostatic bond  at pH < 4.5. The rate of CMP self-assembly was decreased or even was deleted  with increasing salt concentration, maybe by an excessive neutralization of CMP  charge. The presence of salts impacted on the first stage of CMP self-assembly  of by the formation of tetramers linked by hydrophobic bonds.","palabras_clave":"caseinomacropéptido|sales|autoensamblaje|nanoestructuras"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35458,"idioma_id":5,"titulo":"Articulación interinstitucional de docencia y extensión para la producción hortícola sustentable tendiente a la reinserción laboral y mejora de la calidad de vida de jóvenes en situación de riesgo.","resumen":"La actividad hortícola, entre sus múltiples posibilidades, representa una  oportunidad de reinserción laboral para jóvenes en situación de riesgo (JSR)  a través de implementación de proyectos productivos interinstitucionales con  enfoque sistémico (PPIES). A fin de impulsar producciones hortícolas sustentables  de calidad, como estrategia para la expansión del sector hortícola en Olavarría,  la reinserción social de JSR y mejora de la calidad de vida de los habitantes,  se generó el proyecto interinstitucional ?Hacia la diferenciación de productos  hortícolas con potencial regional: caso La Granja?. Se efectuaron capacitaciones,  implementación de protocolos y planillas de registro; se equipó un área de  poscosecha y se acondicionó en fresco la producción lograda. La contribución  del proyecto no sólo estuvo relacionada con mejores resultados productivos,  en rendimiento y calidad, sino que además contribuyó a la mejora de factores  psicológicos y emocionales observados en el cambio de actitud, lo cual aumentó  las sensaciones positivas del grupo.","palabras_clave":"HORTICULTURA|CAPACITACION|JOVENES|SUSTENTABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35503,"idioma_id":4,"titulo":"Herschel, Spitzer and Magellan infrared observations of the complex star forming region RCW121 (IRAS17149-3916)","resumen":"We present new deep near-infrared broad- and narrow-band imaging and low-resolution spectroscopy of the star formation region RCW 121 (IRAS 17149-3916) which we analyse in combination with Herschel (70, 160, 250, 350 and 500 &#956;m) and Spitzer (3.6, 4.5, 5.8 and 8 microns) images. The near-infrared photometry reveals the presence of a stellar cluster of approximate size of 92 arcsec which is composed of at least 264 members, approximately 25 per cent of these showing excess emission at lambda &gt; 2.0 micron, indicative of circumstellar discs. Isochrones corresponding to ages 0.5-1.0 Myr and A_V = 7.8 fit well the position of a large fraction of likely cluster members in the Ks versus H - Ks diagram. We find three massive star-forming cores located in the boundaries of an expanding H II region ionized by a central O-type star. From their far-infrared spectral energy distributions (SEDs) we derive masses and temperatures of the dense cores. When these young stellar objects (YSOs) have warm emission components, the 1.2-500 micron SEDs are fitted with Robitaille et al.´s star-disc-envelope model to obtain their physical parameters. The masses of the three YSOs are between 8 and 10 M_sun. The youngest site (core I) is undetected at lambda &lt; 100 micron and is at the earliest evolutionary stage that can currently be detected. The other two cores (II and III) contain YSOs of similar masses and have near-infrared counterparts, which imply a more advanced evolutionary stage. The YSO at core II has been found to have associated a jet, with strong H_2 line emission, co-existing with an H_2O maser source. RCW 121 is another example of multiple star formation being triggered by the expansion of a single H II region.","palabras_clave":"STARS:FORMATION|ISM:INFRARED|ISM:HII REGIONS|ISM: CLOUDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35551,"idioma_id":5,"titulo":"Condicionantes para la formación de capital productivo. Un análisis a partir de las pymes industriales de una economía regional","resumen":"La dinámica industrial de los últimos años en la Argentina ha despertado un intenso debate en torno a los factores que explican (potencian y limitan) el desarrollo productivo. Es de interés en este trabajo discurrir por el sendero de la formación de capital como elemento clave en el proceso de reconstrucción del tejido industrial. Ahora bien, distinguir dicho proceso en agentes productivos pymes de subsectores industriales característicos de una economía regional contribuye a la definición de las restricciones presentes en términos de los medios disponibles y dificultades para afianzar dicho desarrollo.","palabras_clave":"INVERSION Y FORMACION DE CAPITAL|FINANCIAMIENTO Y CREDITOS|DIFERENCIAS ENTRE AGENTES PRODUCTIVOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35587,"idioma_id":5,"titulo":"Cuidados paliativos. Acompañamiento y dignidad al final de la vida","resumen":"En esta publicación reflexionamos acerca de los cuidados paliativos, como una forma de abordaje interdisciplinario para el final de la vida, en el acompañamiento del paciente y su familia. Los cuidados paliativos comprenden la prevención y manejo eficaz del dolor y otros síntomas perturbadores, en conjunto con el cuidado emocional, atendiendo a todos los aspectos prioritarios de la atención del paciente y su entorno familiar. Implica disponer y acompañar al paciente para una muerte afrontada con dignidad. ","palabras_clave":"BIOETICA|CUIDADOS PALIATIVOS|FINAL DE VIDA|DIGNIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35604,"idioma_id":4,"titulo":"CH3N=SF2=NCH3: Structural, Conformational, and Configurational Properties in the Gaseous and in the Condensed Phases","resumen":"CH3N=SF2=NCH3 (1) was obtained in 88% yield from the reaction of a bis(silylated) amine RN(SiMe3)2 with a sulfur tetrafluoride imide RN=SF4 (R = R = CH3). Single crystals suitable for X-ray crystallography were obtained by low-temperature crystallization; the data were collected at 120 K. Compound 1 crystallizes in the monoclinic space group P21\/c with a = 5.8356(7) Å, b = 12.1665(14) Å, c = 8.1488(8) Å, Beta = 110.381(7)°, Z = 4, in the anti-anti form (whereby anti or syn describe the orientation of the N-CH3 bonds with respect to opposite S=N bonds). The structural, conformational, and configurational properties of CH3N=SF2=NCH3 were  studied by vibrational spectroscopy [IR (gas) and Raman (liquid)] and quantum chemical calculations [B3LYP and MP2 with 6-311+G(2df,p) and cc-pVTZ basis sets]. Vibrational spectroscopy in the gas and liquid phases shows evidence of a configurational equilibrium of the anti-anti form and a slightly less favored anti-syn form of CH3N=SF2=NCH3.","palabras_clave":"SULFUR DIFLUORIDE DIIMIDES|VIBRATIONAL SPECTROSCOPY|QUANTUM CHEMISTRY|CONFORMATIONAL ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35606,"idioma_id":5,"titulo":"Historia eruptiva de los volcanes monogenéticos de El Toro (23º 05´S ? 66º 42´W), Puna norte, Argentina.","resumen":"The monogenetic volcanism from the El Toro region (23º 05' S - 66º 42' W) in NW Argentina comprises a group of low-volume (< 5 Km2) mafic volcanic rocks erupted during the Late Miocene-Pliocene in the northern Puna (Andean Central Volcanic Zone). The activity of at least four eruptive centers resulted in the discharge of several lava flows from a cluster of cinder cones, whose architecture coincides with the typical facies model defined for edifices constructed during Strombolian style eruptions. In some cases, volcanoes recorded brief phases of transitional Hawaiian activity that resulted in small and localized fire-fountaining (occasionally with oblique development), responsible for the generation of agglutinated deposits as spatter and clastogenic lava. These highly welded products, still hot and ductile, may have acted as zones of weakness from which the edifices collapsed gravitationally during lava effusions (rafting process). The latter suggests that effusive and pyroclastic eruptions sometimes may have been coeval.   Volcanic rocks are geochemically classified as arc-like, high-K calc-alkaline basalts, basaltic andesites and andesites. Although geochemically indistinguishable, some rocks have significantly different petrographic characteristics (phenocryst assemblage, % of crystals). This suggests that some volcanic rocks from El Toro represent the eruption of very similar magma batches that show strong differences in temperature and degree of crystallization, i.e., batches evolving at different crustal depths and\/or with different magma chamber residence times. On the other hand, magmas of different chemical compositions were erupted almost simultaneously from the same vents. This intriguing compositional pattern demonstrates that short-lived monogenetic volcanoes may have a complex polymagmatic character.","palabras_clave":"Volcanes monogenéticos|Mioceno superior|Puna norte|Estromboliano"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35623,"idioma_id":5,"titulo":"Inotxicación por Cestrum parqui L´HER. (Duraznillo Negro) en bovinos y su confirmación por análisis micrográfico del contenido ruminal","resumen":"En el reino vegetal existen numerosas especies hepatotóxicas para el ganado bovino, siendo la mayoría de las intoxicaciones de curso agudo a sub-agudo. Dentro de los vegetales hepatotóxicos agudos más conocidos en Argentina se encuentran el ?duraznillo negro? (Cestrum parqui), el ?sunchillo? (Wedelia glauca), el ?abrojo grande? (Xanthium cavaniliensi) y la ?transparente? (Mioporum laetum). Cestrum parqui pertenece a las Solanáceas y en su composición química se ha demostrado la presencia de glicósidos, saponinas, y alcaloides responsables de los efectos tóxicos. El objetivo del presente trabajo es presentar los hallazgos anatomopatológicos macroscópicos, microscópicos, hematológicos y el estudio micrográfico del contenido ruminal de muestras obtenidas de bovinos que ingirieron Cestrum Parqui en forma accidental. Vaquillonas cruza Abeerdeen Angus x Hereford fueron halladas muertas en un corral con buena oferta forrajera y abundantes plantas de ?duraznillo negro?, se tomaron muestras para análisis clínicos, estudios histopatológicos y análisis de contenido ruminal. Los resultados demostraron alteración de las enzimas hepáticas, reticulado tóxico en hígado y presencia de hojas de Cestrum parqui cuya identidad botánica se confirmó mediante micrografía. Esta última técnica constituye una herramienta diagnóstica valiosa para la identificación de la especie vegetal involucrada en este tipo de intoxicaciones.","palabras_clave":"BOVINO|INTOXICACIÓN|CESTRUM PARQUI|CONTENIDO RUMINAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35630,"idioma_id":5,"titulo":"Orígenes y progreso de la queloniología en la Argentina","resumen":"Desde hace milenios las tortugas forman parte del universo mítico de diversas culturas humanas. En consecuencia, el saber empírico de transmisión oral, el uso contextualizado y el significado simbólico de estos animales superan en antigüedad y extensión al conocimiento académico sobre ellos lo que no los exceptúa, sin embargo, de ser actualmente los vertebrados más amenazados del planeta. Este trabajo compendia la labor de exploradores y naturalistas que sentaron las bases de la herpetología sudamericana en general y el estudio científico de los quelonios, en particular, con énfasis en la Argentina.. Se reconoce la tarea de Marcos Freiberg como fundamental para el desarrollo en nuestro país de la queloniología como disciplina en sí misma, y se expone brevemente el avance de ésta en las últimas décadas.","palabras_clave":"HISTORIOGRAFIA|BIOGRAFIAS|TORTUGAS|TESTUDINES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35632,"idioma_id":4,"titulo":"Mesoclemmys vanderhaegei (Bour 1973)  Vanderhaege´s Toad-headed Turtle, Karumbé-hy.","resumen":"Vanderhaegae´s Toad-headed Turtle, Mesoclemmys vanderhaegei (Family Chelidae), is a poorly known freshwater turtle that is widely distributed in central South America. It occurs in the Amazonas, Tocantins, Paraguay, Parana, and Uruguay River basins, where it inhabits shallow streams, ponds, and marshes. Its taxonomic status has long been uncertain and confusion with similar looking species of toad-headed turtles still occurs frequently, leading to erroneous distribution records. Adults can reach up to 285 mm straight carapace length. No subspecies are currently recognized, although there are obvious differences in shell, iris coloration, and body size among populations. The species seems to rely mainly on a carnivorous or opportunistic omnivorous diet. Females are capable of depositing more than one clutch per year with a mean clutch size of 6.4 ± 3.9 eggs. Due to its great ecological adaptability, the species occurs in pristine habitats as well as agricultural and urban areas, but with a cryptic lifestyle. There is little known about its basic ecology except for local studies in Brazil, but detailed ecological surveys in Paraguay and Argentina are lacking. The current population status cannot be fully determined.","palabras_clave":"TURTLES|CHELIDAE|MESOCLEMYS VANDERHAEGEI|BIOLOGY|CONSERVATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35634,"idioma_id":5,"titulo":"Parasitoidismo de huevos de Tibraca limbativentris Stal (Hemiptera: Pentatomidae), en arroz (Oryza sativa L.) en Panamá","resumen":"La especie registrada en las áreas experimentales muestreadas, fue Telenomus podisi (Hymenoptera: Platygastridae), parasitando huevos de Tibraca limbativentris (Heteroptera: Pentatomidae), en el cultivo del arroz, en las localidades de Chichebre y Paso Blanco, Panamá, Panamá. La asociación entre T. podisi y T. limbativentris, se considera el primer informe para Panamá, en donde la tasa de parasitismo promedio fue de 91%.","palabras_clave":"PARASITOIDES|PENTATOMIDAE|PANAMA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35661,"idioma_id":5,"titulo":"Monsieur Pain o los comienzos de un escritor melancólico","resumen":"Monsieur Pain condensa temas, tonos, intenciones que Bolaño retomará y desplegará en narrativas posteriores. En esta novela se anuncia y da nacimiento al escritor melancólico de los 90 y crea un precursor: el escritor derrotado, el héroe fracasado de la lucha republicana, en el melancólico César Vallejo.","palabras_clave":"BOLAÑO|COMIENZOS|MEMORIA|MELANCOLÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35675,"idioma_id":4,"titulo":"Electrochemical Regulation of Budding Yeast Polarity","resumen":"Cells are naturally surrounded by organized electrical signals in the form of local ion fluxes, membrane potential, and electric fields (EFs) at their surface. Although the contribution of electrochemical elements to cell polarity and migration is beginning to be appreciated, underlying mechanisms are not known. Here we show that an exogenous EF can orient cell polarization in budding yeast (Saccharomyces cerevisiae) cells, directing the growth of mating projections towards sites of hyperpolarized membrane potential, while directing bud emergence in the opposite direction, towards sites of depolarized potential. Using an optogenetic approach, we demonstrate that a local change in membrane potential triggered by light is sufficient to direct cell polarization. Screens for mutants with altered EF responses identify genes involved in transducing electrochemical signals to the polarity machinery. Membrane potential, which is regulated by the potassium transporter Trk1p, is required for polarity orientation during mating and EF response. Membrane potential may regulate membrane charges through negatively charged phosphatidylserines (PSs), which act to position the Cdc42p-based polarity machinery. These studies thus define an electrochemical pathway that directs the orientation of cell polarization.","palabras_clave":"ELECTROCHEMISTRY|CELL POLARITY|YEAST|S. CEREVISIAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35749,"idioma_id":5,"titulo":"Sobre el origen del concepto de inmanencia en Gilles Deleuze","resumen":"El concepto de inmanencia desempeña un rol fundamental en la filosofía de Gilles Deleuze. Si bien suele destacarse su noción de plano de inmanencia, el pensador francés elaboró un enfoque integral sobre este concepto, conectándolo con problemas políticos (el capitalismo es descripto como un sistema inmanente) y éticos (la moral universal es sustituida por una ética de valores inmanentes). Los comentaristas han reparado en las distintas formulaciones del concepto, no obstante lo cual no han investigado aún, de manera exhaustiva, el modo en que aparece por primera vez en su obra. En razón de ello, nos proponemos en este trabajo analizar el contexto de origen de la idea deleuziana de inmanencia, que involucra aspectos filosóficos y filológicos. De acuerdo con nuestra hipótesis, la primera aparición del concepto se sitúa en Spinoza et le problème de l´expression (1968), donde nuestro autor inscribe a Spinoza en la tradición de la univocatio entis iniciada por Duns Escoto. Sostenemos que la inmanencia deleuziana abreva en dos perspectivas: la tesis escotista de la univocatio entis frente a la analogia entis de filiación aristotélico-tomista y la causa sui espinoziana frente a la causa emanativa neoplatónica y la causa analógica tomista. La fórmula Inmanencia = Univocidad, puesta de relieve por Badiou, expresa este anudamiento conceptual que hemos de desarrollar. Desde el punto de vista filológico, mostraremos que Deleuze acuña el giro ser inmanado, al momento de describir la especificidad de la causa inmanente, a partir de un uso peculiar de los verbos del latín manare y manere.               ","palabras_clave":"DELEUZE|DUNS ESCOTO|SPINOZA|INMANENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35753,"idioma_id":5,"titulo":"Nietzsche en Deleuze: ser unívoco y pensamiento nómade","resumen":"Los estudios sobre la interpretación de Nietzsche realizada por Gilles Deleuze suelen concentrarse en su influyente trabajo Nietzsche et la philosophie (1962). La presentación de Nietzsche como un pensador anti-dialéctico expresó una voluntad, propia del campo filosófico francés de los años sesenta, de escapar de Hegel. Ahora bien, nuestra atención en el presente artículo se dirige a la caracterización de Nietzsche como pensador de la univocidad del ser, desplegada en Différence et répétition (1968), en virtud de la importancia que tiene este enfoque en el marco del proyecto deleuziano de inversión del platonismo y del aristotelismo. Frente a la tradición aristotélico-tomista, que gira en torno al ser análogo y el pensamiento categorial, Deleuze esgrime el ser unívoco y un pensamiento nómade. El filósofo francés traza una genealogía de la univocidad que le otorga a Nietzsche un rol preponderante, pues el eterno retorno es considerado la realización efectiva de esta tradición. Nuestra propuesta es desarrollar los rasgos principales de la tesis deleuziana de la univocatio a fin de esclarecer la especificidad de Nietzsche en la inversión del mundo de la representación.                                                                               ","palabras_clave":"DELEUZE|NIETZSCHE|UNIVOCIDAD|ANALOGÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35789,"idioma_id":5,"titulo":"La reflexión estética de Marcuse en la escena del instituto de Investigación Social","resumen":"Es sabido que el trabajo del grupo de Frankfurt bajo la dirección de Horkheimer respondía a una suerte de división entre sus miembros, ligada a los intereses de los propios investigadores y su formación, pero a su vez direccionada por los proyectos colectivos. En esta ?división del trabajo?, Marcuse era el encargado de profundizar los análisis relativos a la historia de las ideas. Esta orientación, desde luego, no implica una relación excluyente a otros análisis, que también emprendería, sino que señala incluso cierto reconocimiento al conocimiento que Marcuse demostraba de la tradición filosófica con la que continuamente dialogaba, aunque esto le valiera&nbsp; cierta posición inferior en el núcleo del Instituto. No nos detendremos en las particularidades del, por momentos difícil, vínculo que Marcuse mantuvo con el Instituto, pero sí destacaremos aquellos aspectos conceptuales que tuvieron una significación profunda en su propio pensamiento. Las obras publicadas en este período de filiación íntima de Marcuse con el núcleo del Institut, además de poseer una impronta horkheimeriana, incluyen desde luego la perspectiva hegeliano-marxista de algunos de los conceptos esbozados en las secciones anteriores. Aún así, la profundización de las críticas a las consecuencias indeseadas de la modernidad filosófica, los análisis históricos específicos de la forma de la racionalidad contemporánea, las implicancias de la pregunta por la felicidad humana y la evaluación crítica e interdisciplinaria del rol del arte, la imaginación y la fantasía, son elementos propios de la elaboración teórica de este conjunto de filósofos críticos con los que Marcuse trabajó, intensamente, de 1933 a 1950.","palabras_clave":"Marcuse|Estética|Teoría crítica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35793,"idioma_id":5,"titulo":"DERECHO CONSTITUCIONAL DEL TRABAJO: EL APORTE  DE GERMAN BIDART CAMPOS","resumen":"El trabajo pretende reflejar y resaltar la importancia de la doctrina iuslaboralista elaborada por el profesor Germán Bidart Campos, dimensionando el alcance que sus aportes  tuvieron, tienen y seguirán teniendo en la resignificación del atalaya constitucional desde el cual deben ser vistas las relaciones laborales.   El opúsculo presenta el pensamiento constitucional del catedrático, en grupos temáticos -desde la fuente directa y literal- resaltando las principales proyecciones que el autor perpetrara sobre las normas jurídicas y las actuaciones de los poderes estatales que regularon el derecho del trabajo argentino de los últimos cincuenta años.   El abanico temático compendiado permite visualizar como el estilete del escritor se introdujo en campos tan diversos del mundo laboral logrando desentrañar el meollo constitucional de la situación puesta en foco revelando, además, la perennidad del análisis pues muchas de sus observaciones fueron emitidas en perspicaz soledad y el paso de los años las convirtieron en verdades sacrosantas para la jurisprudencia y la doctrina del país.","palabras_clave":"DERECHO CONSTITUCIONAL DEL TRABAJO|GERMÁN BIDART CAMPOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35855,"idioma_id":5,"titulo":"Contrastes de frontera. Farmers y criollos en los prolego&#769;menos de la gran expansio&#769;n agraria de la Provincia de Santa Fe (1856-1875)","resumen":"El artículo procura analizar un espacio de frontera en Santa Fe durante las dos primeras de&#769;cadas del proceso de colonizacio&#769;n agri&#769;cola que transformari&#769;a la estructura socioecono&#769;mica provincial. No se tratara&#769; so&#769;lo de indagar sobre las colonias, sino un espacio determinado, ya poblado y en parte puesto en produccio&#769;n, en el cual estas colonias se instalari&#769;an, provocando una ruptura de magnitud, pero sin dejar por ello de interactuar con la poblacio&#769;n nativa. Es decir, se intentara&#769; estudiarlo como un espacio de frontera donde pasaron a convivir inmigrantes y criollos con pautas culturales y econo&#769;micas diferentes, a veces complementarias y otras no, y en el cual todavi&#769;a no estaba claro que una de ellas terminari&#769;a imponie&#769;ndose sobre la otra.","palabras_clave":"Frontera|Farmers|Colonización Agrícola|Orden Social"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35872,"idioma_id":5,"titulo":"Mitos del futuro próximo: textos perdidos y otras materialidades inasibles en la poesía argentina de los noventa. Notas sobre el reensamblado de un corpus","resumen":"En el presente trabajo, la idea de archivo opera como forma de recorrer y revisar históricamente, en sus puntos de emergencia, la poesía argentina de los noventa. A partir de esto, proponemos reensamblar el corpus de los noventa al incorporar analíticamente textos que no formaban parte de ese archivo y objetos, dimensiones y materiales que no fueron considerados teóricamente por la crítica literaria especializada.","palabras_clave":"Poesía argentina de los noventa |Editoriales independientes|Archivo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35877,"idioma_id":5,"titulo":"La plasticidad de la lengua: concepciones de la materialidad en el catálogo de la editorial de poesía argentina VOX","resumen":"Hacia fines de la década de los noventa, la editorial VOX, dirigida por el artista plástico Gustavo López, irrumpe en el campo literario con un catálogo que, con el transcurso del tiempo, reuniría a figuras significativas de la poesía argentina. En este trabajo analizamos las  que encontramos en los principales títulos del catálogo, en diálogo con la propuesta editorial del proyecto.","palabras_clave":"Poesía argentina de los noventa|Editoriales independientes|Ediciones Vox"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35880,"idioma_id":5,"titulo":"La escritura poética y sus soportes en la década de los noventa","resumen":"El presente trabajo propone reflexionar sobre los vínculos entre la escritura poética y sus soportes en la década de los noventa. Para eso, se realizará un recorrido crítico por un corpus de textos pertenecientes al catálogo de dos editoriales independientes de poesía argentina ?Ediciones Deldiego y Vox?, recorrido que tendrá como finalidad desmontar y analizar las figuraciones de la escritura poética en relación a las superficies de inscripción que aparecen en el marco de estos proyectos.","palabras_clave":"Poesía argentina de los noventa|Soportes|Escritura poética"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35884,"idioma_id":5,"titulo":"Calefacción en el sector residencial argentino: primera modelización y estudio de las consecuencias de la sustitución de bombas de calor en reemplazo de calefactores a gas","resumen":"La calefacción representa alrededor del 60% del con-sumo de gas en el sector residencial. El presente tra-bajo, estudia los efectos que sobre el sistema energé-tico y la distribución eléctrica implicaría la sustitución a gran escala de equipos de calefacción a gas natural tipo tiro balanceado por bombas de calor eléctricas, las cuales son parte integrante de los equipos de aire acondicionado frío\/calor que se comercializan","palabras_clave":"uso eficiente de la energía|sector residencial|bombas de calor|calefacción"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35887,"idioma_id":4,"titulo":"Sintering, microstructure and hardness of different alumina-zirconia composites","resumen":"Two commercial 3 mol% yttria-partially stabilized zirconia powders, 0.3  wt% Al2O3-doped (Al-doped Y-PSZ) and without Al2O3 (Y-PSZ), were used to  produce alumina (Al2O3)-zirconia (ZrO2) slip cast composites. The influence of the substitution of Al2O3 either by different Al-doped Y-PSZ contents or 50 vol%Y-PSZ on the sintering kinetic at the intermediate stage was investigated. In addition, the microstructure of Al2O3 and the different composites at temperatures in the range of 1100-1600 0C was studied and related to the sample hardness. An increase in the sintering rate was observed when Aldoped Y-PSZ increased from 22 to 50 vol% or when 50 vol% Y-PSZ was substituted by 50 vol% Al-doped Y-PSZ. 50 vol% ZrO2 was the most effective concentration to reduce the rate of Al2O3 grain growth in the final sintering stage; the Al2O3 grain growth began at lower temperatures and became greater with decreasing the Al-doped Y-PSZ content. On the contrary, the ZrO2 grain growth slightly increased with increasing the Al-doped Y-PSZ concentration. However, for 50 vol% Al-doped Y-PSZ a smaller ZrO2 grain size distribution compared with 50 vol% Y-PSZ could be achieved. As the average Al2O3 grain size of the sintered samples became greater than about 1 &#956;m a markedly decrease in the hardness was found; this occurred at temperatures higher than 1400 0C and 1500 0C for Al2O3 and the composite with 10.5 vol% Al-doped Y-PSZ,respectively.","palabras_clave":"ALUMINA-ZIRCONIA |SINTERING|MICROSTRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35984,"idioma_id":5,"titulo":"Geología y petrología del Granito Tres Cerritos,  extremo meridional de la Sierra de Quilmes y su relación con el magmatismo Devónico-Carbonífero de las Sierras Pampeanas","resumen":"El Granito Tres Cerritos está ubicado en el extremo SE de la Sierra de Quilmes, en el departamento Santa María, provincia de Catamarca, en el ambiente morfoestructural de Sierras Pampeanas Septentrionales. El basamento metamórfico de la zona de estudio está constituido por esquistos de bajo y mediano grado metamórfico pertenecientes al Complejo Tolombón, que son afectadas por una faja de cizalla formada con anterioridad al emplazamiento del intrusivo. Localmente se produce metamorfismo de contacto con formación de porfiroblastos de cordierita y biotita. El Granito Tres Cerritos aflora en dos sectores, uno de mayor extensión, de unos 6 km2 de superficie,  de forma elongada con su eje mayor de 4 km de rumbo submeridional y otro más pequeño, que aflora al oeste del área de estudio, de unos 3,9 Km de largo por 250 m de ancho, aproximadamente. Composicionalmente varía entre sienogranito a monzogranito y presenta tres facies: porfírica biotítica, porfírica moscovítica y equigranular moscovítica. Geoquímicamente se define como un granito calco-alcalino y peraluminoso, con alto potasio. Según dataciones K\/Ar este granito sería de edad carbonífera superior. Las características petrográficas, geoquímicas y geocronológicas del Granito Tres Cerritos son similares a la de los intrusivos devónico-carboníferos de las Sierras Pampeanas de Catamarca, La Rioja, Córdoba y San Luis, por lo que el Granito Tres Cerritos formaría parte de un evento magmático de gran extensión areal, post-orogénico o de intraplaca, que afectó a las Sierras Pampeanas durante el Devónico-Carbonífero","palabras_clave":"PETROLOGIA|GRANITO |TRES CERRITOS|SIERRA QUILMES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":35999,"idioma_id":5,"titulo":"Imágenes estadísticas en la cultura visual de la Argentina moderna.","resumen":"Desde las últimas décadas  del siglo XIX, estadísticos con diversa formación y mayor o menor cercanía a  los círculos políticos e intelectuales de la época se abocaron en Argentina a  generar un cúmulo creciente de cifras estadísticas desde reparticiones  estatales creadas a esos fines. El método visual fue uno de los elegidos por  ellos para transmitir el conocimiento social producido desde el Estado y hacer  circular esas representaciones numéricas dentro y fuera del país. El saber  estadístico como objeto de estudio es sumamente interesante por combinar un doble  registro de autoridad, la de la ciencia y la del Estado. Explorar la propuesta  gráfica de la estadística pública argentina entre 1890 y 1930 nos permite conocer  el modo específico en que un actividad especializada contribuyó a la formación de  una cultura visual vinculada a la práctica científica en un contexto histórico  particular como el del cambio de siglo. En este artículo se identifican los  patrones, las reglas o convenciones de representación visual presentes en los  gráficos estadísticos producidos por la comunidad especializada. Así, se describe  aquello que denominamos la propuesta gráfica de la estadística oficial y se analiza  el proceso de construcción social de la significación a través de imágenes  estadísticas.","palabras_clave":"GRÁFICOS ESTADÍSTICOS|ESTADÍSTICAS|CULTURA VISUAL|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36004,"idioma_id":4,"titulo":"Surface alterations produced in grinding of Austempered Ductile Iron","resumen":"The technological advances achieved in recent decades have allowed to obtain cast parts of ductile iron with no metallurgical&lt;br \/&gt;defects and of complex shapes and dimensions very close to the final ones. Heat treatments have enabled to obtain ADI within a&lt;br \/&gt;wide range of mechanical properties. After properly choosing the processing variables, the most suitable combination of strength&lt;br \/&gt;and toughness can be attained for each application. When restrictive dimensional or shape accuracy is required, a high precision&lt;br \/&gt;machining process, such as grinding, is used. This process induces significant temperature gradients and surface plastic&lt;br \/&gt;deformations which could affect the surface characteristics. The aim of this paper is to analyze the effects of grinding on power&lt;br \/&gt;consumption, surface characteristics, roughness and distortion on ADI plates grade 2 and 5. The results indicate that it is possible&lt;br \/&gt;to achieve excellent surface finishes with moderate power consumption and low residual stresses and distortions.","palabras_clave":"ADI|grinding|microstructure|distortion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36057,"idioma_id":5,"titulo":"Estudio exploratorio en estudiantes universitarios. Referencias sociodemográficasy elección de carrera","resumen":"El problema que se ha  indagado se vincula a la necesidad de conocer las características de los jóvenes que ingresan a la vida universitaria dando cuenta de algunas referencias psicosociales de los mismos a los Identificar características de la población de distintas carreras universitarias de modo que permita señalar particularidades psicosociales de la misma en relación a las trayectorias personales y escolares. A su vez se tuvo como objetivo indagar sobre  rasgos distintivos de cada población para establecer algunas relaciones entre disposiciones previas, elección de carrera y trayecto universitario, Se trabajó con la población de tres carreras diferentes, Licenciatura en Psicología, Licenciatura en Diseño Gráfico y Contador Público, en una universidad privada de la ciudad de Córdoba. La metodología utilizada fue de enfoque mixto, utilizando encuestas y entrevistas. Se presentan, en esta oportunidad, los primeros resultados relativos a aspectos sociodemográficos y elección de carrera.","palabras_clave":"Vida universitaria|Elección de carrera|estudiantes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36122,"idioma_id":5,"titulo":"Calidad de los datos de encuestas sobre consumo de alcohol en estudiantes universitarios","resumen":"Diferentes modalidades de encuesta han sido desarrolladas para medir el consumo de alcohol y los problemas relacionados. La investigación sobre la calidad de los datos en distintas modalidades de encuesta es escasa en Latinoamérica. El objetivo de este estudio es evaluar la calidad de los datos sobre consumo de alcohol resultante de tres modalidades de encuesta: auto-administrada online, auto-administrada a papel y lápiz y entrevistas cara a cara. Los datos se obtuvieron de tres muestras probabilísticas (n=60 cada una) de estudiantes de la Universidad Nacional de Mar del Plata, Argentina, usando el mismo cuestionario. Para cada modalidad, la calidad de los datos se estimó con la tasa de respuesta global, tasa de respuesta al ítem y la precisión. La precisión fue evaluada con el porcentaje de consumo excesivo episódico, resultado positivo del AUDIT, y consistencia interna del AUDIT. Las tasas de respuesta global y al ítem fueron menores en la modalidad online, y similares en las restantes dos. No se encontraron diferencias en la precisión de las respuestas entre las modalidades.","palabras_clave":"CALIDAD DE DATOS|ALCOHOL|ESTUDIANTES UNIVERSITARIOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36134,"idioma_id":5,"titulo":"El Partido Peronista: problemas organizativos, prácticas políticas y liderazgo en tres momentos de normalización partidaria","resumen":"          En los  últimos años la historiografía ha avanzado en la revisión de los escenarios  donde las prácticas políticas de los peronistas se orientaron hacia la  conformación y consolidación de un partido distrital, provincial o incluso  nacional, permitiendo advertir algunas recurrencias y ciertos conflictos que se  repiten a lo largo de las geografías provinciales y el decenio de los dos  primeros gobiernos de Perón. Ha sido menos frecuente percibir que tales  problemas organizativos se prolongaron en el tiempo. La periodización, los  distintos repertorios de problemáticas a investigar y las distancias entre las  disciplinas que se ocupan del período llamado de la resistencia y del ?tercer?  peronismo, han demorado esa posibilidad.        Este  artículo es un intento por leer en clave comparada tres momentos organizativos  del Partido Peronista. El momento 1946-1947; el momento 1963-1964; y un tercer  proceso, 1972-1973. El principal objetivo es instalar en un primer plano  algunos problemas que el peronismo encontró en su histórico devenir en tanto  organización, bajo el supuesto de que esos problemas, por momentos poco  percibidos por sus protagonistas, están vinculados al modo en que los partidos  políticos carismáticos tramitan sus tensiones internas.   ","palabras_clave":"Partidos Políticos|; Partido Peronista"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36137,"idioma_id":5,"titulo":"El hecho de que sean más mujeres, no garantiza nada': feminización y experiencias de las mujeres en la ginecobstetricia en México","resumen":"en el marco de la creciente feminización de la profesión médica en México, el artículo indaga sobre las características de este proceso para el caso de la ginecobstetricia. Considerando la feminización como un proceso de cambio, que se analiza cuantitativa y cualitativamente, el artículo se detiene en especial en las experiencias de las mujeres ginecobstetras, experiencias que se dan en el seno de una especialidad que, desde sus orígenes, funcionó como un dispositivo de control del cuerpo de las mujeres. Basado en una investigación etnográfica, el artículo combina fuentes estadísticas, de archivo y de observación de campo. El material que surge de las entrevistas muestra las experiencias y tensiones que viven las ginecobstetras en este contexto.","palabras_clave":"GENERO|MEDICINA|GINECOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36147,"idioma_id":5,"titulo":"La asociación de recursos de valoración: el caso de las organizaciones de derechos humanos en la prensa escrita argentina","resumen":"En las últimas décadas hemos presenciado uncreciente interés por los estudios del lenguaje desdeperspectivas críticas, fundados en la necesidad dedevelar posicionamientos ideológicos que atentan, amenudo, contra los intereses de grupos de limitadopoder social. A fin de develar los posicionamientos, yen consecuencia la construcción y consolidación deideologías a lo largo del tiempo, la teoría de la valoración(Martin, 2000; Martin y White, 2005), en el marcode la Lingüística Sistémico Funcional (LSF), brinda herramientasde particular valor en el análisis de discursosde medios. Este marco se combina y enriquece conpropuestas que comparten la base que responden alos postulados del enfoque sociohistórico discursivopropuesto por Reisigl y Wodak (2001) y por Wodak yMeyer (2003). La visión del lenguaje como práctica social(Fairclough y Wodak, 1997) es compartida por laLSF, en tanto esta se constituye como teoría lingüísticamultifuncional al servicio del análisis del discursocomo entidad construida por los propios propósitossociales a los que contribuye, y visualiza al lenguajecomo una forma de semiótica social (Halliday, 1978;Halliday y Matthiessen, 2014). Este trabajo proponeilustrar el uso estratégico de recursos evaluativos ysu asociación a partir del análisis de noticias publicadasen cinco influyentes diarios argentinos. Todos losartículos fueron publicados con motivo de un hechode violencia de gran impacto social acaecido a mediadosde 1985, época marcada por el retorno de lademocracia al país, en medio de una marcha militarliderada por el entonces presidente Alfonsín. En estehecho se vio involucrada la agrupación Madres dePlaza de Mayo, grupo formado por madres de las másde 30.000 víctimas de la dictadura militar que gobernóArgentina entre 1976 y 1983. El análisis arroja luzsobre el uso de una amplia variedad de recursos valorativos,tanto de Compromiso como de Actitud, asícomo también un uso vasto de elementos de Gradación,tanto infundidos lexicalmente como de formasaisladas. Resulta de particular interés la combinaciónde recursos valorativos realizada por los autores parala construcción de valoraciones de polaridad negativaacerca de las nociones de violencia y de disrupciónde la normalidad. Sin embargo, las mayores diferenciasobservadas no fueron detectadas en los tipos derecursos léxico-gramaticales utilizados, sino en lasdiferentes intensidades de las evaluaciones planteadas.Este fenómeno podría dar cuenta de la imposibilidadde recurrir a otras opciones de construcción discursivamediática viables que resulten políticamentecorrectas en un momento sociohistórico dado, comoel que se analiza. Los resultados pueden contribuir ala comprensión del funcionamiento de los recursoslingüísticos por los que se construyen y consolidanposicionamientos ideológicos en la sociedad modernamediatizada.","palabras_clave":"Teoría de la Valoración|Discurso de Medios|Derechos Humanos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36186,"idioma_id":4,"titulo":"Achalaite, IMA 2013-103. CNMNC Newsletter No. 19, February 2014, p. 166","resumen":"Wodginite group. Monoclinic: C2\/c a = 9.422(4), b = 11.427(3), c = 5.120(1) A &#730; , b =90.12(4)º 3.630(40), 2.964(100), 2.564(35), 2.493(40), 1.766(35), 1.735(40), 1.711(50), 1.453(40).Type material is deposited in the collections of the Museo de Mineralogía y Geología 'Dr. Alfred Stelzner', Universidad Nacional de Córdoba, Cordoba, Argentina, cataloguenumber 3279.","palabras_clave":"Achalaite|Córdoba, Argentina|Wodginite group|New species"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36191,"idioma_id":5,"titulo":"Cada prostituta en su lugar.  La sexualidad para definir el espacio urbano","resumen":"    Este artículo parte  del análisis de los discursos sociales acerca del espacio prostibulario en  tanto son espacios estratégicos de producción, circulación y reforzamiento de  los imaginarios sociales sobre la prostitución. La articulación teórica de los  llamados estudios de género y los estudios de las ciudades desde la  comunicación será útil para repensar los usos del espacio público que se  proponen desde las políticas públicas institucionales y los itinerarios territoriales  que elabora la ciudadanía en torno a la sexualidad.   Este  proceso permitirá identificar la delimitación de los espacios de diversión,  cómo el tiempo resignifica el espacio, las fronteras sexuales, la invisibilidad  de la prostitución y las relaciones de poder que sostienen o cuestionan el mapa  urbano de la sexualidad. El objetivo de este trabajo será reconstruir las  disputas por el espacio y su articulación con la construcción hegemónica de la  sexualidad femenina.","palabras_clave":"Espacio público|Prostitución|Sexualidad|Las Casitas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36198,"idioma_id":5,"titulo":"Aportes para el estudio de la vanguardia biológica latinoamericana","resumen":"A partir de la exposición de las características principales del bioarte, buscaremos comprender el objetivo de este género artístico contemporáneo que ejemplifica un modo transdisciplinar de producción de obras. En este sentido, intentaremos pensar el lugar del arte frente al corrimiento de las fronteras tradicionales que lo separan de la ciencia.  Luego de la aparición de obras vivas, como la emblemática coneja Alba de Eduardo Kac, nos preguntamos sobre la relación entre los artistas y los científicos en el laboratorio. ¿Cómo se trabaja en un laboratorio de bioarte? ¿Qué imaginarios de arte y de ciencia se ponen en juego? ¿Qué consecuencias trae la producción conjunta de obras?  A partir de entrevistas en profundidad realizadas a bioartistas y de focus group realizados en el BIOLAB (Laboratorio Argentino de Bioarte) de la Universidad Maimónides -único en América Latina-, procuraremos familiarizarnos con el modo de producción de conocimiento que esta comunidad mixta genera. Asimismo, buscaremos poner en evidencia las tensiones que existen al interior de la misma, vinculadas a las expectativas y usos que cada parte proyecta para los resultados obtenidos.  Si bien es poco lo que se ha avanzado en el análisis teórico del bioarte, es importante el aporte que desde la teoría del arte y la teoría de la ciencia se puede hacer de este cruce transdisciplinar que ejemplifica la crisis del modo de producción de conocimiento heredado del positivismo. La comprensión de esta práctica artística -que por lo extrema de sus características corre el riesgo de perder su identidad crítica- supone el replanteo de muchas categorías metodológicas y epistemológicas propias de la biología que no deberían esquivar el debate.  Algo cambió en el arte y en la ciencia para que hoy podamos hablar de bioarte. Comprender de qué se trata\/n ese\/os cambio\/s es el objetivo que nos proponemos para poder seguir pensando en lo que nos propuso Vilém Flusser en su conferencia del año 1982: ?(?) exceder el divorcio entre ciencia y arte no es, entonces, mero compromiso epistemológico o estético, sino compromiso con una nueva sociedad?.","palabras_clave":"ARTE LATINOAMERICANO|CIENCIA|TRANSDISCIPLINA|VANGUARDIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36202,"idioma_id":5,"titulo":"Caminando hacia una respiración saludable. Estrategias vinculadas hacia la prevención y asistencia en niños respiradores bucales.","resumen":"Las acciones desarrolladas en el proyecto de extensión ?Mejorando la calidad de vida en respiradores bucales?, subsidiado en 2011 y acreditado en 2012, por la Universidad Nacional de La Plata, llevadas a cabo en centros educativos de la ciudad de Berisso, a partir de una metodología participativa interactiva, establecieron vínculos favorables hacia la promoción y prevención de la salud en distintas comunidades. La respiración, proceso fundamental del organismo, se realiza por vía nasal en condiciones normales, sin embargo ante la presencia de alteraciones en las vías aéreas superiores, el cuerpo realiza esta función por vía bucal. Como consecuencia se generan cambios, faciales, craneales, dentales, posturales y fisiológicos o de comportamiento. Ante la falta de la debida atención y la inquietud de docentes frente a esta problemática argumenta nuestra intervención ya que cuanto más temprano sea su detección facilita la atención oportuna. El intercambio de conocimientos a partir de experiencias en talleres, la utilización de folletos ilustrativos y proyección de videos que se realizaron durante nuestra intervención en años anteriores, posibilitó a padres y tutores de los niños tomar conciencia y valorar la necesidad de atender los trastornos respiratorios. Los logros obtenidos en respuesta a las actividades desarrolladas fueron posibles ya que la totalidad de padres autorizaron por escrito que sus hijos participen de las actividades, y sean evaluados mediante las pruebas de funcionabilidad propuestas en el proyecto. Teniendo en cuenta el resultado positivo de las tareas realizadas hasta este momento, se pretende asegurar la sostenibilidad de logros. Considerando los objetivos propuestos en el mencionado proyecto, en cuanto a obtener mayor demanda de consultas y la disminución de niños respiradores bucales en las escuelas, se propone continuidad de las actividades y su replicabilidad en otros grupos etarios de las comunidades educativas, a fin de extender la cobertura. De esta manera se pretende dar respuesta a la necesidad de información requerida por otros padres, quienes hasta el momento desconocen la problemática. Asimismo debido al alto impacto producido por las tareas realizadas, se podrá responder a la solicitud de directivos de las instituciones, quienes desean la incorporación de otros niños.","palabras_clave":"RESPIRACION|PREVENCION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36313,"idioma_id":10,"titulo":"ADAPTATIVIDADE GEOCULTURAL EM AMBIENTES VIRTUAIS DE APRENDIZAGEM","resumen":"At the present time the access to digital contents is one of the most important techniques to learning support. Although there are multiple systems with this goal, little attention is given to the adaptation to the cultural characteristics of these contents related to the apprentice?s geographic location. The focus of this paper is to contribute to the development of digital inclusion and peoples? learning abilities through the construction of a digital ecosystem. The aim is to develop student?s abilities to expand skills in collaborative learning activities to build and share knowledge in a social context. This interaction when expanded to large groups of participants of different nationalities bumps into implementation difficulties arising from geo-cultural characteristics. Our work deals with the analysis of these characteristics to allow the expansion of virtual learning environments for large groups of students. This concern with the specific characteristics of students from different regions is one of the major obstacles to the implementation of Massive open online courses (MOOC)","palabras_clave":"ambientes virtuais de aprendizagem|trajetórias de aprendizagem|geocultural|adaptabilidade"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36315,"idioma_id":5,"titulo":"Análisis del comportamiento contextual del usuario y su relación con el consumo de aplicaciones móviles","resumen":"El mercado de aplicaciones móviles crece aceleradamente, captando la atención sobre el análisis del consumo de las mismas para mejorar su recomendación y la satisfacción del usuario, soportado en la búsqueda de información que permita explicar la ocurrencia de eventos del ciclo de vida de las aplicaciones. En este sentido algunos estudios muestran una fuerte relación entre dichos eventos e información sobre la situación contextual actual del usuario y su registro de consumo de aplicaciones. Sin embargo, dichos trabajos no consideran la relación existente entre el registro de estados de las dimensiones contextuales (denominado como CUBe) y la ocurrencia de eventos del ciclo de vida de las aplicaciones, tal como lo hace este estudio. En este sentido, se presenta un análisis estadístico sobre un dataset real, evidenciando una fuerte relación entre el CUBe y el lanzamiento de un conjunto de aplicaciones. Finalmente, se describe un escenario donde estas relaciones pueden ser utilizadas para enriquecer sistemas de recomendación para aplicaciones móviles.","palabras_clave":"análisis contextual del comportamiento|usuario|aplicaciones móviles"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36329,"idioma_id":4,"titulo":"Materials Science Forum","resumen":"The ability of zirconia ceramics to develop a bioactive surface is of great importance for  biomedical applications. For that, it is also required to control phase stability (i.e. to avoid the  tetragonal to monoclinic phase transformation) of zirconia surfaces in order to impart a high  mechanical resistance. In this work, the phase stability of dense 3 mol% yttria stabilized-zirconia  (3Y-TSZ) ceramics after acid and hydrothermal treatments was examined. Ceramic discs were  prepared by slip casting from well dispersed 52 vol% suspensions, and subsequently sintered to  1300-1500 °C. The effect of various synthesis parameters and 0.25 wt% alumina doping on the  phase transformation after acid and hydrothermal treatments was semi-quantitatively evaluated by  XRD. The 3Y-TSZ sintered to 1500°C exhibited higher t&#8594;m transformation than samples sintered  at lower temperatures. The phase transformation up to 10h of hydrothermal treatment occurred by  nucleation and growth mechanisms in which the nucleation process predominated. The presence of  0.25 wt% alumina in 3Y-TSZ sintered at 1500°C slightly enhanced the resistance to acid treatment.","palabras_clave":"Bioceramics|3Y-TSZ|slip casting|phase stability"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36359,"idioma_id":5,"titulo":"EN EL CAMPO, UNA VUELTA DIFERENTE. Autor; Ferdinando Fava. Revisión y Traducción al español: Ludmila Adad","resumen":"El   artículo focaliza  en las modalidades de hacer epistemológicamente   relevantes las interacciones de  campo. El autor, en primera instancia,   analiza la presencia del antropólogo en  la escena etnográfica   recolocando las relaciones de campo en el debate y la  ideología   profesional del fieldwork que  han marcado el fin de los años ?90.               La   renovada  centralidad de la dimensión relacional y de la reflexividad   aparecen enseguida  interrogadas y críticamente reformuladas a partir de   dos elementos eclipsados  de esa misma escena, la implicación y  los enlaces emergentes. Dimensiones  centrales, en cambio, ligadas a una comprensión articulada del proceso de  construcción del saber antropológico.               La modalidad con que los  interlocutores &nbsp;integran   en sus  relaciones sociales concretas al antropólogo atribuyendo   significado a su investigación  y a sus gestos, la posibilidad   estrechamente correlacionada a eso de afincar enlaces  con ellos,   conducen a reconsiderar la originalidad del gesto antropológico desde    su interior y a renovar su envergadura epistemológica frente al devenir   continuo  de las formas sociales contemporáneas.","palabras_clave":"Escena etnográfica|Construccion social del antropólogo|Implicación|Enlaces emergentes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36363,"idioma_id":5,"titulo":"Caracterización de la calidad del agua de dos cuencas del piedemonte andino argentino mediante la aplicación de índices integradores. Tecnología y Ciencias del Agua","resumen":"Este trabajo presenta los resultados de la aplicación del Water Quality Index (WQI) del Canadian Council of Ministers of Environment, con el objeto de caracterizar de manera sintética y gráfica la calidad del agua, considerando un conjunto de parámetros biológicos, físicos y químicos en grandes cuencas. Este índice deja a criterio del investigador la elección de aquellos parámetros que resulten importantes para la zona y que además sean representativos de los distintos usos del agua. Se presentan aquí los resultados obtenidos a partir de una base de datos de calidad de agua de riego de dos cuencas del piedemonte andino argentino, considerando diferentes parámetros y límites sugeridos por el Departamento General de Irrigación de la provincia de Mendoza, un organismo internacional (FAO), las agencias de agua (AE) francesas y un país como Marruecos, cuyo entorno medioambiental es muy similar al analizado. Se concluye que la metodología lleva a una sobrevaloración del Factor 1 del WQI y permite a) manipular los resultados al incluir en la construcción del índice parámetros más\/menos favorables; b) modificar dicho factor para disminuir su peso en el cálculo del índice, y c) no obstante todas las limitaciones detectadas, resulta útil para la comparación de la calidad del agua entre distintos sitios y\/o cuencas regadías ","palabras_clave":"INDICE DE CALIDAD DEL AGUA|RIEGO|CONTAMINACION|MENDOZA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36400,"idioma_id":5,"titulo":"Las figuras de espectador en el arte contemporáneo. El caso del bioarte","resumen":"Eneste artículo se describen las distintas figuras de espectador que construyen lasobras de bioarte asentadas en los diversos dispositivos del arte contemporáneo talescomo instalaciones, ambientaciones, eventos participativos o performances. Deeste modo emergen las figuras de espectador-observador, espectador-testigo, espectador-invitado, espectadorintruso, espectador-protagonista y espectador-coproductor que serán analizadasy descriptas a través de un corpus de bioarte argentino e internacional.","palabras_clave":"ESPECTADOR|BIOARTE |ARTE |CONTEMPORANEO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36406,"idioma_id":5,"titulo":"Reseña: Clínica de Proyectos Artísticos","resumen":"La Clínica de Proyectos Artísticos tuvo como fin generar un espacio de intercambio y supervisión para la concreción de proyectos o ideas acerca de las prácticas artísticas contemporáneas, que combinan las artes digitales con la danza y la performance.","palabras_clave":"PROYECTOS|ARTÍSTICOS|PERFORMANCE|NUEVAS TECNOLOGÍAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36419,"idioma_id":5,"titulo":"Desmonte y soja en una provincia del norte argentino: implicaciones ecosistémicas y socioeconómicas","resumen":"En Santiago del Estero (una provincia 'extrapampeana') se incrementó la superficie de las explotaciones agropecuarias (EAP) durante el período 1998-2002. Al mismo tiempo, la superficie con bosques y montes espontáneos disminuyó. Estos cambios en el uso del suelo impactan sobre el ambiente implicando modificaciones de los servicios ecosistémicos y los sistemas socioeconómicos que se extienden mas allá de los límites provinciales. Siendo nuestra hipótesis que la proporción de desmonte varía según el tipo de explotación agropecuaria sojera, el objetivo de este trabajo es analizar las diferencias entre los distintos tipos de productores sojeros, con respecto al desmonte. Se elaboró una tipología de EAP según la proporción de trabajo familiar empleado. La participación relativa de los bosques y montes espontáneos y de los pastizales ha disminuido en todos los tipos de EAP, pero las unidades familiares mantuvieron un porcentaje mayor de bosques y montes espontáneos en algunas localizaciones.","palabras_clave":"soja|desmonte|explotaciones familiares"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36447,"idioma_id":4,"titulo":"Arsenic immunotoxicity and immunomodulation by phytochemicals: Potential relations to develop chemopreventive approaches","resumen":"Arsenic (As) contaminates drinking water worldwide, and As exposure, hypersensitivity and deficiency are involved in the immunopathogenesis of various health problems. Its chemoprevention thus has a high health impact. Given its oxidative potential, antioxidant compounds are good candidates to counteract arsenic´s deleterious effects on humans. Phytochemicals (e.g., phenolics, carotenoids, etc.) act through free radical chelation activity and regulation of cellular targets. In consequence, they are appropriate for developing anti-As strategies derived from plants, and Argentinean flora are rich in useful species. Several molecular pathways involved in immune regulation are at the same time targets of exogenous agents, and oxidative stress itself is a modulating phenomenon of immunity. Since xenohormesis has been described as the organic enhancement of resistance to stress conditions (e.g., oxidation, pollution, etc.) by consuming xenobiotics, immunoxenohormesis implies also defense improvement. This review focuses on recent patents on the development of vegetable redox-related immunomodulating agents, which might be applied in As-induced dysfunctions, with their scientific basis being reviewed.","palabras_clave":"Antioxidant|Arsenicosis|Chemoprevention|Phytomedicine"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36494,"idioma_id":4,"titulo":"&#65532;Book Review: TCP\/IP Illustrated, Volume 1 nd The Protocols, 2 edition Kevin R. Fall - W. Richard Stevens ISBN 0-321-33631-3 Pearson Education, Inc. 2012","resumen":"Book Review:TCP\/IP Illustrated, Volume 1The Protocols, 2nd editionKevin R. Fall - W. Richard Stevens ISBN 0-321-33631-3 Pearson Education, Inc. 2012","palabras_clave":"NETWORKS|PROTOCOLS|TCP|IP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36552,"idioma_id":5,"titulo":"Dificultad al Acceso de Bienes Inmuebles en el Proceso de Valorización de la Periferia Rosarina, Argentina","resumen":"En la última década, la creciente especulación de la tierra y la insuficiencia de crédito hipotecario han dificultado el acceso de algunos sectores de la población en el borde urbano de la ciudad de Rosario. La reducción de compra se ve más acentuada  en el mercado residencial, particularmente en los sectores medios y bajos. El presente artículo tiene como objeto evaluar la dinámica inmobiliaria y el impacto de la valorización en las propiedades de los principales mercados (residencial e industrial) en el área de estudio. A partir de la comparación entre la evolución de los precios (viviendas y galpones tipo) y la evolución  de los ingresos (familias y Pymes) se conocen los cambios del esfuerzo monetario. En consecuencia, los resultados expuestos cuantifican la reducción del poder de compra y evidencian la expansión de la demanda de alquiler, creando una gran segmentación socio-espacial, cada vez más acentuada en la periferia.","palabras_clave":"ACCESO A PROPIEDADES|ALQUILER|MERCADO INMOBILIARIO|PERIFERIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36582,"idioma_id":5,"titulo":"La costosa fiesta de la frivolidad","resumen":"Nos encontramos transitando en una era de la inmediatez, de falta de juicio crítico, una época de proliferación del pensamiento vacuo e intrascendente, pero ¿Nos puede afectar en algo la ausencia o superficialidad del pensamiento? Para responder a ese interrogante la Magister en Filosofía Viviana Sargiotto, nos invita a reflexionar a partir del pensamiento filosófico de Hannah Arendt sobre la importancia que asigna la filosofía al pensar reflexivamente para vivir y alcanzar la dignidad humana.","palabras_clave":"BANALIDAD DEL MAL|SUPERFLUO|FILOSOFIA|PENSAMIENTO CRÍTICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36593,"idioma_id":5,"titulo":"OnicomicosisEstudio retrospectivo sobre epidemiología y tratamiento,Hospital San Juan de Dios, La Plata (2009-2012)","resumen":"Introducción: las onicomicosis representan el 50% de las onicopatías. El tratamiento es prolongado y costoso, presentando altas tasas de abandono. Objetivos: evaluar las características epidemiológicas de los pacientes que fueron atendidos por onicomicosis, valorar la adhesión al tratamiento y su respuesta. Métodos: se realizó un estudio descriptivo, restrospectivo, constituido por 307 historias clínicas de pacientes con diagnóstico clínico y microbiológico de onicomicosis, tratados en el Hospital San Juan de Dios de La Plata en el período 2009-2012. Resultados: se encontró mayor frecuencia de consultas en el sexo femenino (64,14%), la localización principal fue en uñas de pie (81,11%), la infección por dermatofitos fue más frecuente en uñas de pies (79,21%) y por levaduras en manos (75%). Un 43,32% de la población presentó comorbilidades. El tratamiento sistémico con terbinafina o itraconazol en pulsos fue de elección para la infección por dermatofitos (96,74%), presentando respuestas clínicas similares pero menor recaída con itraconazol. Los casos con tratamiento tópico combinado (amorolofina) tuvieron mejores respuestas. La tasa de abandono fue elevada (51%). Conclusiones: en cuanto a las características epidemiológicas de las onicomicosis se encontraron datos similares a la bibliografía consultada; por el contrario, se proporciona una estadística diferente respecto de la respuesta clínica de las onicomicosis al tratamiento sistémico en pulsos.","palabras_clave":"ONICOMICOSIS|DERMATOFITOS|LEVADURAS|ITRACONAZOL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36615,"idioma_id":5,"titulo":"Prevención de enfermedades cardiovasculares en la niñez","resumen":"Este artículo brinda información sobre actividades de extensión basadas en uno  de los pilares de la Atención Primaria de la Salud (APS) que es la prevención,  específicamente en la etapa de la niñez. Se detallan las intervenciones realizadas  mediante la articulación de las comunidades educativas del nivel primario con las  del universitario, con profesionales del servicio de cardiología, y de las inquietudes que fueron presentadas en el gobierno provincial.","palabras_clave":"ECNT|PREVENCIÓN|NIÑEZ"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36636,"idioma_id":5,"titulo":"Coagulación optimizada en el tratamiento de potabilización del agua: Su efecto sobre la remoción de enteroparásitos","resumen":"En la década de 1970 se informó que el cloro que se empleaba para desinfectar el agua de bebida, al reaccionar con la materia orgánica natural (NOM) tales como ácidos húmicos y fúlvicos, generaba nuevos compuestos orgánicos, como subproductos, considerados cancerígenos según estudios toxicológicos y epidemiológicos.  El tipo específico y la cantidad de subproductos de la desinfección (DBPs) generados por la cloración dependen de la calidad del agua sin tratar, de las prácticas de cloración, de la temperatura del agua y del pH.   Para lograr una disminución de los DBPs se plantea el proceso de coagulación optimizada (CO), mediante la cual se intenta mejorar la remoción de NOM. Entre las distintas técnicas propuestas para tal fin la mayoría de los autores coinciden en la elección del método por ajuste de pH de coagulación.  Dentro de los microorganismos que pueden ser transmitidos por el agua, los quistes y ooquistes de enteroparásitos cobran gran importancia por los numerosos episodios epidémicos atribuidos a estos organismos en países de avanzada tecnología en la potabilización del agua.  La eliminación de quistes y ooquistes de enteroparásitos por el proceso de potabilización es relevante y presenta un desafío para las plantas de tratamiento, ya que si sobrepasan las barreras de coagulación y filtración, la desinfección es poco efectiva para eliminarlos debido a su característica resistencia a la misma.  Los objetivos fueron:   Evaluar en ensayos de laboratorio, los efectos de modificaciones de pH de coagulación del proceso de potabilización en la remoción de materia orgánica natural, utilizando los coagulantes más comúnmente empleados en esta etapa.   Analizar si estas modificaciones tienen algún impacto en la eliminación de quistes de Giardia intestinalis y ooquistes de Cryptosporidium spp.  El agua cruda que se utilizó en los ensayos proviene de la Planta potabilizadora de la ciudad de Santa Fe (Argentina).  Se realizaron concentraciones de materia fecal de humanos infectados, logrando suspensiones de alrededor de 105\/mL ooquistes de Cryptosporidium y quistes de Giardia.  Para simular los procesos de coagulación, floculación y sedimentación, se empleó la prueba de jarras (jar test), un modo práctico para hallar las dosis requeridas de coagulantes y otros condicionantes que los afectan, a fin de trasladar los resultados a planta. Para analizar la remoción de NOM y los enteroparásitos (Cryptosporidium spp. y Giardia intestinalis) fueron seleccionados 3 diferentes coagulantes (sulfato de aluminio, cloruro férrico y polihidroxicloruro de aluminio) y cuatro niveles de pH. Para CO se ensayaron pH 5,0; 6,5; 8,0 y para la coagulación convencional (CC) no se realizó ninguna modificación del pH. Se realizaron un total de 84 ensayos. Para la identificación y recuento de (oo)quistes de enteroparásitos se empleó el método de inmunofluorescencia con anticuerpos monoclonales. La medición de NOM se realizó por absorción de UV 254 nm.  En la metodología estadística se emplearon técnicas no paramétricas para la comparación de las variables analizadas.   Para la remoción de NOM de los coagulantes a base de aluminio se encontró que no hay diferencia estadísticamente significativa cuando se aplica CC y CO (pH 5 y 6,5). Para el sulfato de aluminio, se observaron reducciones, comprendidas entre 83 y 88 %, en todos los casos superiores a las logradas con PACl.","palabras_clave":"enteroparásitos|tratamiento de potabilización|Coagulación optimizada"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36646,"idioma_id":5,"titulo":"Entre el juego y el deporte","resumen":"El juego deportivo es un juego que raya el límite con la práctica corporal dominante de la modernidad que sugiere eficacia y eficiencia de movimiento sujeto a reglas universalmente reconocidas, es decir, el deporte.   En este artículo se analiza la relación entre juego y deporte, dos prácticas corporales con alta presencia en las prácticas docentes de Educación Física; se describe el juego deportivo como contenido orientado a la enseñanza del deporte, y se abre la discusión acerca del impacto educativo de su implementación en la escuela. Hacia el final se invita a los docentes a desaprender recorridos trazados, disfrutar jugando con los alumnos, lanzarse al vacío, animarse a perder pie ser un buen jugador.","palabras_clave":"JUEGO|DEPORTE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36681,"idioma_id":5,"titulo":"El positivismo jurídico y la relación entre Derecho y Moral","resumen":"Hoy en día nadie duda que 'el tema', el gran tópico de la iusfilosofía en particular se refiere a las posibles conexiones entre moral y derecho, o a las eventuales diferencias que pueden encontrarse entre ambas disciplinas normativas. Somos conscientes de que no hay originalidad en el planteo de esta cuestión.   Tengamos en cuenta que el subtitulo de este trabajo, hace referencia al debate moderno y contemporáneo en torno al derecho y la moral, por lo que podemos tomar a Kant como el pensador que inicia, hacia fines del siglo XVIII, la cuestión referida a lo que el considera como una separación tajante entre el mundo de lo jurídico y el mundo de la ética.","palabras_clave":"POSITIVISMO|MORAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36683,"idioma_id":5,"titulo":"PROCESO DE CRECIMIENTO EMPRESARIAL EN PYMES: ANÁLISIS DE CASOS EN EL SECTOR DE SOFTWARE Y SERVICIOS INFORMÁTICOS","resumen":"Las empresas de base tecnológica son reconocidas como importantes motores del desarrollo de países y regiones, y muchos estudios se han realizado para determinar los atributos asociados a su crecimiento. Sin embargo, el análisis desde una visión holística de los procesos dinámicos acumulativos que desarrollan en su interior, ha recibido menos atención en la literatura. El presente trabajo propone identificar y examinar diferentes factores que afectan el crecimiento de las PyMEs de la región Centro de la Provincia de Buenos Aires a partir del análisis de casos de empresas del Sector de Software y Servicios Informáticos, el cual se encuentra en una etapa en que se abren algunas oportunidades interesantes, a la vez que aparecen interrogantes relacionados con sus posibilidades de crecimiento y la trayectoria de especialización esperable y deseable.","palabras_clave":"CRECIMIENTO EMPRESARIAL|PYMES|SOFTWARE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36710,"idioma_id":5,"titulo":"Incidencia del marketing territorial en la comunicación y la cultura urbana metropolitana","resumen":"Elejercicio del derecho a la ciudad enfrenta sucesivas y dinámicas reconfiguraciones,ya sea desde la capacidad material de su uso, como de los intercambios de losactores sociales y políticos en las representaciones y operaciones simbólicassobre ella. Mientras todaciudad como sistema de comunicación resulta un espacio de aprendizaje social através de la experiencia vivida, en el caso del área metropolitana de BuenosAires (AMBA) también consideramos la trascendencia del relato sobre el espaciourbano, dada su condición estratégica de puerto\/puerta, cabecera de redesproductivas y de servicios, así como la centralidad mediática que opera en formametonímica sobre la Argentina toda. &nbsp;&nbsp;Sibien acordamos con una mirada amplia sobre las industrias culturales y lagestión del patrimonio cultural y urbano, este artículo focalizará sobre loscriterios utilizados actualmente por algunas intendencias para posicionar yexplotar las intervenciones públicas en el espacio urbano con expectativas de reconocimiento,tanto por los propios ciudadanos de cada distrito como por el público delentorno metropolitano y nacional que es referenciado, ya sea en las propiasproyecciones buscadas por la política pública, como por el esquema de mediosmasivos de comunicación y las redes de movilidad, tránsito y relacionamientovirtual existentes.","palabras_clave":"Territorio|Metropolitana|Cultura|Planificación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36737,"idioma_id":4,"titulo":"Applying high resolution SyXRD analysis on sulfate attacked concrete field samples","resumen":"High resolution synchrotron X-ray diffraction (SyXRD) was applied for a  microstructural profile analysis of concrete deterioration after sulfate attack. The cementmatrices consist of ordinary Portland cement and different amounts of supplementary cementitious materials, such as fly ash, natural pozzolana and granulated blast furnace slag. The changes of the phase composition were determined along the direction of sulfate ingress.  This approach allows the identification of reaction fronts and zones of different phase compositions and conclusions about the mechanisms of sulfate attack. Two reaction fronts were localized in the initial 4 mm from the sample surface. Themechanism of deterioration caused by the exposition in the sulfate-bearing soil is discussed.  SyXRD is shown to be a reliablemethod for investigation of cementitiousmaterials with aggregates embedded in natural environments.","palabras_clave":"X-ray diffraction|Sulfate attack|Concrete"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36751,"idioma_id":5,"titulo":"Estructura de clases en la Argentina. Un estado de la cuestión","resumen":"El presente trabajo busca aproximarse a un estado de la cuestión referido a los estudios sobre estructura de clases en la Argentina. Para eso, intentaremos sintetizar los principales aportes e investigaciones referidas al tema, con el fin de introducir al lector en un conjunto de trabajos que, tomados de conjunto, advierten distintas aproximaciones sobre el problema de investigación.","palabras_clave":"ESTRUCTURA SOCIAL|CLASE TRABAJADORA|MERCADO DE TRABAJO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36753,"idioma_id":5,"titulo":"La relación entre moral y derecho en el paleopositivismo y el positivismo Jurídico. Aportes para una crónica","resumen":"En este trabajo se realiza una crónica histórica de las relaciones entre moral y derecho, tal como las concibiera el positivismo jurídico, desde los desarrollos de Austin hasta los planteos de Hart, efectuados en su mayor parte a partir de la década del 60, durante el siglo XX. Resulta interesante advertir que, de una posición en la que se negaba toda posibilidad de una metafísica, en la que se postulaba una neutralidad valorativa, como ocurría con las tesis de Austin y de Kelsen, se ha ido desarrollando progresivamente la idea de que una unión entre moral y derecho no sólo es posible, sino que incluso resulta necesaria. Esto resulta particularmente destacable en Hart, autor que ha tenido una concluyente evolución en este sentido. El autor concluye que la admisión, por parte del último Hart, de un positivismo ?suave? que incluya cierta idea moral, ha sido una bocanada de aire fresco para la teoría general del derecho que ha contribuido a la adecuada protección de los derechos humanos. Ello ha permitido un avance cierto en el desarrollo de las ideas jurídicas contemporáneas.","palabras_clave":"DEREHO MORAL|FORMALISMO|POSITIVISMO JURÍDICO|JUSTICIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36755,"idioma_id":5,"titulo":"Gradientes térmicos del suelo superficial cultivado con maíz en labranza convencional y en siembra directa","resumen":"La siembra directa produce impactos en el suelo en relación con su potencial capacidad de producción de los cultivos. Los residuos de cosecha esparcidos sobre el suelo ejercen una significativa influencia en la temperatura del mismo, disminuyendo su radiación absorbida al favorecer la reflectancia de la misma. La relación entre el calentamiento del suelo y los contenidos de humedad edáfica actúa en forma inversa a su contenido, ya que la energía radiativa incidente en el suelo será absorbida en parte, por la mayor capacidad calórica del agua disponible. El calentamiento del suelo dependerá de la cantidad de radiación neta que se encuentre en la superficie terrestre resultado de considerar el balance de radiación de onda corta y de onda larga. El presente trabajo tiene como objetivo indagar sobre las modificaciones que produce el tipo de labranza sobre los gradientes térmicos en el suelo cercano a superficie. Los efectos producidos por clase de labranza, tipo y grado de cobertura de rastrojos sobre las propiedades físicas del suelo y desempeño de maíz, soja, sorgo y trigo están siendo evaluados en un experimento en curso sobre rotación de cultivos, localizado en el Campo Experimental de la CNEA - Ezeiza, Provincia de Buenos Aires, incluido en la subregión de Pampa Ondulada (34° 49? 01?? LS, 58° 34? 16?? LW). Para el análisis se consideró el periodo de estudio en dos. El primer período abarcó desde el día de la siembra hasta el cultivo en estadíos entre V6 y V8, procurando evitar que el efecto de sombreado del entresurco provocado por la canopia del maíz, donde se hallaban instalados los sensores de temperatura del suelo, extinga diferencias presumibles al tipo de labranza. El segundo período abarcó el ciclo completo para este cultivo buscando de esta manera, mediante variables acumuladas a lo largo del mismo, maximizar posibles diferencias térmicas entre labranzas. Las temperaturas en el suelo fueron registradas en parcelas de labranza convencional (LC) y siembra directa (SD) a 25 y 50 mm de profundidad cada 10 minutos. Paso seguido se calcularon los gradientes correspondientes dividiendo las diferencias térmicas establecidas por la distancia vertical entre sensores en cada labranza. Otra información meteorológica utilizada complementariamente corresponde a los registros horarios de la estación Ezeiza (aero) del S.M.N., próxima al ensayo. En concordancia con otros autores, las diferencias térmicas entre la SD y la LC se deben a la menor radiación de onda corta absorbida en la SD produciendo que, al menos en las horas diurnas, el suelo bajo ella permanezca más frío que en la LC. Días con lluvia que mojan el perfil, dada la baja temperatura del agua precipitada, a su alta capacidad calórica y alto calor latente de evaporación logran extinguir las diferencias térmicas en el suelo bajo ambas labranzas durante su ocurrencia y perduran proporcionalmente a su cantidad. El suelo comienza a calentarse en ambas labranzas aproximadamente dos horas después de la salida del sol, no mostrando diferencias entre ellas. En cambio comienza a enfriarse junto con la puesta del sol en LC y hasta una hora antes en SD. Las duraciones de las recargas de energía (gradiente positivo) fueron mayores en LC que en SD. Mientras que complementario a esto las duraciones de las descargas de energía (gradiente negativo) fueron mayores en SD que en LC. La suma de aspectos favorables para una mayor carga en LC, reflejados en la diferencia de los gradientes térmicos positivos, resulta evidente; se debe a la diferente absorción de radiación solar y a las duraciones de recarga a favor de la LC respecto de SD","palabras_clave":"TEMPERATURA DEL SUELO|GRADIENTE TÉRMICO|MAÍZ|SIEMBRA DIRECTA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36757,"idioma_id":5,"titulo":"Un socialismo propio para Nuestramérica","resumen":"Las luchas contra el neoliberalismo iniciadas hace más de dos décadas en América Latina dieron visibilidad a un potencial de transformación que actualizó el interés por los orígenes históricos del continente. En los procesos de revolución democrática en curso, ha comenzado a tomar forma la discusión sobre los elementos propios del socialismo nuestroamericano. En este trabajo recuperamos la noción de ?socialismo raizal? del sociólogo colombiano Orlando Fals Borda, para trazar puentes con la concepción de ?Buen vivir? y el ?socialismo del siglo XXI?. Sobre estas bases afirmamos la necesidad de un cambio civilizatorio de raíces profundamente democráticas, asentado en el protagonismo de los pueblos del continente.","palabras_clave":"SOCIALISMO|UTOPÍA|EUROCENTRISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36779,"idioma_id":5,"titulo":"RECRIA DE VAQUILLONAS ANGUS EN PROMOCION DE FORRAJERAS INVERNALES BAJO DOS METODOS DE PASTOREO","resumen":"SE PLANTEO COMPARAR EL USO DE PASTOREO CONTINUO CONTROLADO VS PASTOREO ROTATIVO AJUSTADO POR LA FITOMASA AEREA TOTAL, AMBOS CON 3 HEMBRAS\/HA, PARA LOGRAR EL SERVICIO A LOS 13 A 15 MESES DE EDAD DE LAS VAQUILLONAS EN RECRIA SOBRE FORRAJERAS INVERNALES PROMOVIDAS QUIMICAMENTE.","palabras_clave":"VAQUILLONA|RECRIA|ADPV|PASTOREO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36783,"idioma_id":5,"titulo":"PRODUCCION Y CALIDAD DE SEMILLAS DE LOLIUM MULTIFLORUM EN UNA PROMOCION QUIMICA DE ESPECIES INVERNALES","resumen":"El objetivo fue evaluar la producción de semillas y su calidad en una promoción química de especies invernales bajo diferentes modalidades de pastoreo.","palabras_clave":"SEMILLAS|RAIGRAS|PRODUCCION |CALIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36827,"idioma_id":5,"titulo":"Comportamiento de la madera del pino ponderosa (Pinus ponderosa Dougl. ex. Laws.) expuesta a degradación por Gloeophyllum sepiarium (Gloeophyllales, Basidiomycota).","resumen":"RESUMEN  La degradación fúngica es un tipo de deterioro  frecuente y agresivo en la madera en servicio. Por  esto, la resistencia de las maderas al deterioro  producido por los hongos xilófagos constituye una  propiedad de referencia al momento de estimar su  vida útil en condiciones extremas de uso y,  consecuentemente, de definir su condición de uso  más apta. Para una determinada clase de resistencia  a la degradación, el tiempo útil en servicio de una  pieza expuesta a solicitación estructural estará  influenciado por el tipo de pudrición. Las  pudriciones castañas reducen notablemente la  resistencia mecánica. Es objetivo del trabajo  determinar el comportamiento de la madera de Pinus  ponderosa Dougl. ex. Laws. expuesta a  Gloeophyllum sepiarium (Wulf.: Fr.) P. Karst  responsable de pudrición castaña. Se trabajó con  albura proveniente de árboles de 19 años de edad  implantados en Neuquén (Argentina). Las  determinaciones realizadas fueron: resistencia a la  degradación fúngica como también composición  química, flexión estática y densidad normal en  material testigo y expuesto a degradación. P.  ponderosa resultó moderadamente resistente a la  acción de G. sepiarium (pérdida de peso: 35%); en  la madera expuesta a la cepa xilófaga los parámetros  de flexión disminuyeron significativamente respecto  del testigo (MOR en un 49%; MOE en un 55%) con  un valor bajo de pérdida de peso (1,3%), no así la  densidad (testigo: 0,40 g.cm-3; expuesta a  degradación: 0,39 g.cm-3); la degradación fue  evidenciada químicamente e indirectamente  mediante la caída de MOR y MOE.","palabras_clave":"PINO PONDEROSA|PUDRICION CASTAÑA|PROP. FISICO-MECANICAS|COMPOSICION QUIMICA DE LA MADERA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36852,"idioma_id":5,"titulo":"?La deposición de la cólera. Sobre la composición del canto XIX de la Ilíada?","resumen":"De entre los cantos de la Ilíada, el XIX es el que mayorproporción tiene de discursos directos. Nos proponemos mostrar el orden?lógico? y ?psicológico? que los religa, porque si Aristóteles alaba en la obrahomérica la unidad de la acción, puesto que del mito (&#963;&#8059;&#963;&#964;&#945;&#963;&#953;&#962; &#960;&#961;&#945;&#947;&#956;&#8049;&#964;&#969;&#957;; cf. de arte poet. 1450 a 15), también laserie de los discursos de cada canto ? el XIX no es sino un caso prototípico ?se revela en el orden de la expresión (&#955;&#8051;&#958;&#953;&#962;)como un todo ?sabiamente acordado?: &#963;&#8059;&#963;&#964;&#945;&#963;&#953;&#962; &#955;&#8057;&#947;&#969;&#957;.","palabras_clave":"Homero|Ofuscación|Dolor|Virtudes heroicas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36860,"idioma_id":5,"titulo":"La historización de acontecimientos modernistas en el marco de la Nueva Filosofía de la Historia","resumen":"Informe breve sobre el proyecto de investigación en curso, en el marco del Instituto de Filosofía.","palabras_clave":"Informe investigación|Hayden White|Acontecimientos límite"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36863,"idioma_id":4,"titulo":"Modernist Figuration in the Representation of Argentina?s Recent Past","resumen":"In his latest writings Hayden White points out that the survivor's testimonies of limit events such as Holocaust provides the same kind of knowledge that literature and art. He calls Witness Literature to these sort of testimonies and they can be used as a source of information for comprehension of liminal experiences. Thus, he continued the debates opened by his propose to represent limit events using the modernist style, and before that with his claim for the renewal of the historical studies using the innovation provided by the art and the literature. From the perspective of these Hayden White´s works, in this work my aim is to consider critically the use of Witness Literature to represent limit events. I will analyze some representations elaborated by the sons of desaparecidos of the last Argentinean dictatorship to contrast his point of view.","palabras_clave":"Philosophy of History|Modernism|Figuration"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36864,"idioma_id":5,"titulo":"Los orígenes del Realismo Estructural: rastreando la tradición estructuralista en Filosofía de la Ciencia","resumen":"Current debate on Structural Realism (SR) starts when Worrall (1989) suggest that position is capable of accounting for the central intuitions of both Scientific Realism and Antirealism. Since then, it has become a rich field of debate in which complex disputes have emerged. In this paper I maintain that, (a) despite its recent appearance on the philosophical scene, SR constitutes the crowning of an epistemological trend I propose to call ´structuralist tradition´. I take as its central feature to put the focus on the relations that exist in the natural world, rather than in the nature of the entities that maintain those relations. But (b) despite this common feature, the various positions that have constituted that tradition in general, and the variants of RE in particular, have not offered a precise and uniform notion of structure.","palabras_clave":"STRUCTURAL REALISM|SCIENTIFIC REALISM|SCIENTIFIC STRUCTURALISM|STRUCTURALISM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36868,"idioma_id":5,"titulo":"El figuralismo como un modelo estético de interpretación histórica: análisis de la figura de 'hijo de desaparecido'","resumen":"En este trabajo utilizamos la noción de ´figuración´ para dar cuenta de la intervención específica de los hijos de desaparecidos de la última dictadura argentina en el ámbito del discurso de la memoria. Sugerimos que esta comprensión estética del acontecer histórico permite aproximarnos  fructíferamente al análisis de las representaciones del pasado reciente elaboradas por los hijos de desaparecidos de la referida dictadura. En efecto, dada la figura del desaparecido, el hijo de desaparecido puede ser considerado como el cumplimiento de esta figura. Finalmente analizamos  dos documentales que nos permiten contrastar esta sugerencia.","palabras_clave":"Filosofía de la Historia|Discurso de la Memoria|Figuralismo|Subjetividades"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36876,"idioma_id":5,"titulo":"Medios y Periodistasaregntinos Nativos e Inmigrantes en 2012: Facilitadores oContaminadores de la Conversación","resumen":"El trabajo compara el comportamiento en Twitter de medios nativos e inmigrantes y periodistas de estos medios en Argentina, con el objetivo de observar qué tipo de lógicas implementan en relación con los esquemas conversacionales. Estas lógicas pueden configurar un espacio para la difusión y distribución masiva, o más bien facilitar la comunicación a través de la conversación con sus usuarios, buscando un mayor equilibrio entre el decir y el escuchar. Para ello, se seleccionaron cuentas corporativas (de medios) y cuentas de usuarios individuales (periodistas que trabajan en esos medios) separados en un grupo de medios fundado antes de la aparición de la Web Social, y en otro de aparición posterior. Se registró el comportamiento comunicativo de estas cuentas en Twitter durante 12 semanas y se procesaron a partir de categorías que representan la estructura mínima de la conversación, según el paradigma pragmático lingüístico de la CA (Conversation Analysis): actividad, popularidad y reciprocidad. Los valores del registro permiten cotejar el comportamiento de los medios con el de los periodistas y si hay diferencias sustanciales entre los grupos 'nativos' e 'inmigrantes' para concluir sobre su contribución al desarrollo de la conversación pública.","palabras_clave":"Medios|Twitter|Conversación|Web"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36887,"idioma_id":4,"titulo":"Antifeedant and Phagostimulant Activity of Extracts and Pure Compounds from Hymenoxys robusta on Spodoptera exigua (Lepidoptera: Noctuidae) Larvae","resumen":"In this study, the insecticidal and antifeedant activities of compounds from the leaves of Hymenoxys robusta on Spodoptera exigua, also known as armyworm,are reported. The methanol extract possessed suppressive activity, as well as a high antifeedant activity, suggesting that this extract has toxic effects on larvae.Compounds isolated from the plant show that a derivative of inositol and hymenolides stimulate the feeding, while vermeerin shows a high antifeedant effect.In addition, the methanol extract inhibited oviposition, whereas consumption of the n-hexane extract and hymenolides produced infertile eggs. These findingssuggest that compounds extracted from H. robusta have potential for the development of products for pest control.","palabras_clave":"Hymenoxys robusta|Antifeedant activity|Toxicity|Spodoptera exigua"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36918,"idioma_id":5,"titulo":"La densidad de lo Político","resumen":"Los treinta años de democracia ininterrumpidos que se cumplen en Argentina dan lugar a un momento propicio -y necesario- para reflexionar sobre los diferentes escenarios que durante este periodo se han atravesado, las transformaciones logradas, los desafíos y agendas impostergables y los posibles horizontes de una democracia plena que los nuevos tiempos de América Latina permiten imaginar,  soñar y construir.","palabras_clave":"POLÍTICA|DEMOCRACIA|TRASNFORMACIONES|AGENDAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36922,"idioma_id":5,"titulo":"Los saberes académicos en contextos de compromisos","resumen":"El contexto regional actual, en el que se ha revitalizado la política como opción de transformación, nos convoca a construir un modelo académico alternativo al hegemónico. El artículo propone tomar ciertas decisiones epistemológicas ?que son a la vez éticas y políticas? tales como: abrazar un punto de vista de la esperanza, que no sólo vea lo que se ha destruido; pensar las totalidades, en vez de las diseminaciones; comprender la vida social a partir del conflicto, de la multiplicidad de elementos en pugna y en movimiento; habilitar la toma de posición para la producción del saber, en contra de la idea de una ciencia independiente y objetiva; promover el contagio del\/con el otro(s), contra la cultura del laboratorio aséptico; y recuperar la violencia de la teoría, que irrumpe y que trastoca.","palabras_clave":"POLÍTICA|EPISTEMOLOGÍA|CONFLICTO|TOTALIDADES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":36968,"idioma_id":5,"titulo":"EFECTO DEL SISTEMA DE LABRANZA Y LA FERTILIZACIÓN NITROGENADA SOBRE EL RENDIMIENTO DE MAíZ (Zea mays L.) EN uN HAPLuSTOL éNTICO DE LA REGIÓN SEMIÁRIDA PAMPEANA","resumen":"The objective of this study was to evaluate the effect of nitrogen (N) fertilization on corn grain  yield (Zea mays L.) under zero tillage (SD) and conventional tillage (SC). For this purpose, a  field assay using a split-plot experimental design was carried out relying on tillage system (SD,  SC) as main factor and N fertilization rate (0, 60, 120, 180 kg N\/ha) as secondary factor. Soil  moisture and nitrate-N contents were determined at 20 cm intervals to a depth of 60 cm. This  followed sampling done at crop phenological stages V2 (16 December), V6 (15 January), flowering  (11 February) and physiological maturity (28 April). For SD system, corn yield was not  affected by N fertilization at low rates but differed significantly at high rates, while yields for SC  were different even at low rates. Considering the same fertilization treatments, yields for SD  were always higher than those for SC. These results might be explained by the higher moistur","palabras_clave":"SIEMBRA DIRECTA|MAIZ|NITRATOS|FERTILIZACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37041,"idioma_id":5,"titulo":"Celdas de Combustible Biológicas Basadas en el Metabolismo Fotosintético","resumen":"Las celdas de combustible biológicas son dispositivos bio-electroquímicos, donde&nbsp;generalmente el ánodo (pero a veces el cátodo, o ambos) contiene microorganismos capaces de generar y mantener un  gradiente electroquímico que se utiliza típicamentepara generar energía eléctrica. En laconfiguración más estudiada, el ánodo contienebacterias heterótrofas en condiciones anaerobias, capaces de oxidarmoléculas orgánicas, liberando protones  y electrones, así como otros subproductos. Los protones liberados pueden alcanzar el cátodo (típicamente a través de una membrana o un puente salino), mientras que los electrones viajan a través de un circuito externo, originando un flujo de corriente fácilmente medible. Se presentan aquí resultados obtenidos con  distintas configuraciones de celdas de combustible, empleando organismos autótrofos,  plantas y algas. &nbsp;Los resultados  obtenidos indican que la producción de energía por estos dispositivos es aún  muy baja para resultar competitivos con respecto a otros sistemas de  acumulación\/producción de energía eléctrica. La optimización tanto desde el  punto de vista del diseño, materiales de electrodo y catalizadores, selección  y\/o modificación genética de los organismos utilizados, podría permitir en el  futuro utilizar estos sistemas como una fuente de energía renovable adecuada  para una variedad de aplicaciones. &nbsp; ","palabras_clave":"Bioelectroquímica|Energías Renovables|MFC|Curvas de Polarización"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37074,"idioma_id":5,"titulo":"La juventud y el daño en la argentina","resumen":"Desde hace algunos años asistimos a la presencia de un discurso mediático estigmatizador y deshistorizado que asocia a los jóvenes con la muerte, al construirlos desde múltiples relatos como sujetos peligrosos que ponen la vida propia y ajena en riesgo. Con la pretensión de aportar una mirada que supere la  óptica periodística, el presente análisis aborda las prácticas juveniles de riesgo a partir de dos hipótesis: la primera, que las prácticas juveniles donde la vida se pone en riesgo lejos de ser irracionales pueden ser comprendidas en el marco de unos jóvenes socializados en un tiempo de incertidumbre mundial y de vulnerabilidad regional. La segunda conjetura tiene que ver con la relación entre las prácticas juveniles de riesgo y lo que se llamará el daño: las heridas producidas por la dictadura y por 30 años de políticas neoliberales en la región.","palabras_clave":"JÓVENES|MEDIOS|RIESGO|VULNERABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37088,"idioma_id":5,"titulo":"LA TRADUCCIÓN COMO PERFORMANCE: LENGUAJES, CREATIVIDAD Y CONSTRUCCIÓN","resumen":"Este trabajo propone analizar una perspectiva de traducción elaborada sobre el concepto de performance. Observará cómo los adjetivos performático, relativo a la ejecución o puesta en acto de una pieza artística en general, y performativo, vinculado a la instauración de significado o formas de percibir el mundo, se conciben en la traducción de una serie de poemas, llamados performáticos, cuyas características, propias de la poesía en voz alta (polifonía y modos de la voz), conllevan una resistencia mayor a la traducción convencional en la página escrita. A su vez, a través de un recorrido teórico que transita por el lenguaje performativo, el arte de performance, la filosofía y el psicoanálisis (Butler, McSweeney, Toro, Deleuze, Winnicott, etc.) se intenta demostrar que ambos términos (performático y performativo) confluyen para dar cuenta de una forma de traducción con los mismos propósitos. A fin de ilustrar lo anterior, este trabajo observa y sugiere un enfoque performático y a la vez performativo para la traducción de los poemas de Joyelle Mcsweeney.","palabras_clave":"PERFORMANCE|POESIA|TRADUCCIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37091,"idioma_id":5,"titulo":"Hacia el núcleo 'Two English Poems'","resumen":"Los ?Two English Poems? tienen una historia particular: según detalla Borges, fueron escritos en 1934 pero apenas un fragmento de ellos aparece en 1935 en Historia Universal de la Infamia. Allí, figuran como epígrafe de la colección de relatos, junto con una dedicatoria, los versos centrales, por su posición y significado, de lo que posteriormente constituiría el segundo poema de estos Two English Poems: ?I inscribe this book to I.J.: English, innumerable and an Angel. Also: I offer her that kernel of myself that I have saved, somehow the central heart that deals not in words, traffics not with dreams and is untouched by time, by joy, by adversities?. En 1943, los dos poemas ingleses aparecen en Poemas (1922-1943) en su versión definitiva. Sin embargo, se los titula ?Prose Poems for I.J?. No será hasta 1954, en la edición de Poemas (1922-1953) realizada por Losada que ambas piezas se bautizarán con el título ?Two English Poems?. En el primero de los poemas figura una nota al pie de página que aclara que fue escrito para Beatriz Bibiloni Webster de Bullrich. Llamativamente, ese mismo año aparece la segunda edición de Historia Universal de la Infamia y el destinatario del epígrafe-dedicatoria, cambia de I.J. (como establece la primera edición) a S.D. La edición de Poemas a cargo de Emecé (1923-1958), en cambio, registra la dedicatoria de los dos poemas (no únicamente del primero) para Beatriz Bibiloni Webster de Bullrich. Finalmente, hacia 1964 los ?Two English Poems? encontrarán lugar en la colección de poemas El otro, el mismo, preparada por Borges. Bajo el mismo criterio de catalogación pasan a la primera edición de las Obras completas en 1974, supervisadas por el autor.","palabras_clave":"BORGES|CRITICA GENETICA|INGLES|TWO ENGLISH POEMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37096,"idioma_id":5,"titulo":"Poesía y Performance: espacios creados a partir del contacto entre cuerpo, voz, objetos, poesía y tecnología","resumen":"Resumen: Este trabajo propone explorar nuevas formas en que la capacidad  performativa del cuerpo, la voz, los objetos y la tecnología entran en contacto y abren nuevos territorios en la poesía latinoamericana desde las últimas dos  décadas. A su vez, intentará mostrar las diferentes expresiones del concepto  multifacético de ?performance? y lo que este significa o hace posible. A través de la obra de algunos poetas\/performers se observará qué materialidades vuelven  visibles la convergencia entre poesía, performance y tecnología en sus distintas  formas de aparición en escena, e incluso en la escena virtual, qué se entiende  por poesía, qué se entiende por performance y cómo entran en juego las  sonoridades, la música, los espacios y el cuerpo de acuerdo con la impronta  creativa y el universo lingüístico del autor. En este sentido, el presente análisis revela que en las conjugaciones de poesía y performance más actuales parece existir una descorporación del performer para dar lugar a la interacción de otros elementos, para abrir espacios tanto para la poesía como para las voces.","palabras_clave":"Performance|Poesía  Latinoamericana |Cuerpo|Voz"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37099,"idioma_id":5,"titulo":"El manifiesto: expresión apocalíptica de lo moderno: De Marx al posboom latinomericano","resumen":"El presente trabajo se propone leer un género discursivo propio de la modernidad, desde los tonos apocalípticos que lo caracterizan. El manifiesto ha acompañado a las expresiones  modernas  desde una posición ambigua, crítica y de celebración a la vez. La estructura del manifiesto remeda en cierto modo la estructura del apocalipsis. Niega una realidad vigente pero a la vez anuncia la llegada de lo nuevo. Luego de un corto recorrido por los complejos caminos de la modernidad en América Latina, nos detendremos en manifiestos modernistas, vanguardistas y más recientes como los del posboom.","palabras_clave":"Modernidad|Manifiesto|Apocalipsis|Vanguardia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37114,"idioma_id":4,"titulo":"NASAL CARRIAGE OF  Staphylococcus aureus (SA): RESISTANCE TO MACROLIDES AND  LINCOSAMIDES. (ABSTRACT)","resumen":"Nasal carriage of SA has been increasing, as well as resistant to methicillin (MRSA) strains. One alternative therapeutic ismacrolides, lincosamides and streptogramin (MLS). The most frequent MLS-resistant phenotypes are MLSb (methylase)constitutive (cMLSb) and inducible (iMLSb), and MSb (efflux).The aim of this study was to determine the frequency ofresistance to erythromycin and clindamycin SA isolates from nasal swabs among medical students at UNR. The collectedsamples were cultured onto mannitol salt agar. Identification was performed by conventional tests. To determine theantimicrobial susceptibility Kirby Bauer method was applied in accordance with Clinical and Laboratory StandardsInstitute (CLSI). For quality control strain ATCC 25923 was used. A total of 233 samples were processed, SA was isolatedin 60 (25.75%), of which 4 were found to be MRSA. Regarding resistance MLS group, only two showed cMLSB SAisolates iMLSB 15 (25% of SA isolates). According to these results erythromycin and clindamycin would not be a validalternative to empirical treatment of infections SA. We must continue working towards a greater number of isolates SA.","palabras_clave":"STAPHYLOCOCCUS AUREUS|PORTACION|RESISTENCIA A MACROLIDOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37187,"idioma_id":5,"titulo":"Simultaneidad Lingüística en la ficción de Junot Díaz y su traducción","resumen":"Los traductores enfrentan un gran desafío al traducir un texto escrito en  varias lenguas, pues deben poner en práctica diversas estrategias para lograr una tensión lingüística similar en el texto meta. La tensión lingüística que caracteriza a estos textos es artística y políticamente significativa. La traducción del cambio de código desafía la concepción de traducción tradicional: la transposición de un código lingüístico cerrado a otro. Este artículo no se centra en criticar la difícil tarea de los traductores que emprenden la compleja misión de recrear estos textos para que lleguen a otro público, ni en lamentos sobre lo que se pierde en la traducción. El objetivo de este trabajo es analizar las formas empleadas por los traductores para transponer la simultaneidad lingüística del texto fuente en sus versiones y los efectos que tienen estas estrategias para el público lector. La metodología consiste en comparar dos traducciones al español del cuento de Junot Díaz 'Wildwood' (2007) con el propósito de descubrir las estrategias empleadas por los traductores para recrear la tensión lingüística entre el español y el inglés en sus respectivas versiones.","palabras_clave":"CAMBIO DE CÓDIGO|ESTRATEGIAS DE TRADUCCIÓN|SIMULTANEIDAD LINGÜÍSTICA|TENSIÓN LINGÜíSTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37207,"idioma_id":5,"titulo":"Las palabras y el proceso","resumen":"Se trata de la traducción del trabajo del Profesor Ordinario Faculta di Giurisprudenza UNIROMATRE, Eligio Resta. El trabajo en su idioma original se titula 'Le parole e il processo'  y esta dedicado a las palabras de la ley, a la semántica histórica que las acompaña, al juego de sentido y al significado que ellas evocanSe adjunta el trabajo  traducido  que fue remitido a la editorial.  Fue publicado en Jurisprudencia Argentina NUMERO ESPECIAL el 28\/05\/14  Fasciculo 9, 2014 II","palabras_clave":"PROCESO|UN MUNDO DE PALABRAS|RETOS|DECIR Y PROCEDER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37209,"idioma_id":5,"titulo":"Investigación y generación del conocimiento","resumen":"Se trata de una entrevista en torno a temas relativos a la epistemologìa y a la metodología de la investigación en ciencias sociales. También se tratan reflexiones en torno a la investigación académica, los temas a investigar, las perspectivas interdisciplinarias desde las cuales abordarlos, los procedimientos para llevar adelante un trabajo de investigación, la difusión de los resultados de las investigaciones el compromiso universitario y estatal en relación a estos temas","palabras_clave":"INVESTIGACION|CONOCIMIENTO|METODOLOGIA|INVESTIGACIÓN SOCIO JURIDICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37243,"idioma_id":5,"titulo":"Inmigrantes en la ciudad de Buenos Aires: demarcaciones y recorridos","resumen":"El artículo trata sobre recorridos y representaciones de inmigrantes bolivianos\/as en la ciudad de Buenos Aires. Los lugares para vivir, para trabajar, para pasar el tiempo libre y para reunirse y diseñar actividades y acciones colectivas se encuentran para estos\/as migrantes en un área acotada del sur de la ciudad. Un conjunto de sitios, conexiones e hitos cotidianos marcan un mapa que para muchos constituye 'el' mapa de 'la' ciudad de Buenos Aires. Hay calles, esquinas y manzanas que son reconocidas como 'bolivianas' por los propios migrantes y por los vecinos no bolivianos. Las marcas y las conexiones sedimentadas históricamente van cargando esta parte de la ciudad y predisponen, positiva y negativamente, unos determinados circuitos urbanos. Para muchos\/as de los\/as migrantes que viven (habitan, trabajan, se divierten y recrean) en esta zona, el área circunscribe sus prácticas y sus imágenes de la ciudad. La ciudad aparece demarcada, con fronteras conocidas aunque muchas veces imperceptibles y probablemente invisibles para un visitante reciente, y se muestra peligrosa, la circulación pública no está nunca exenta de riesgos. Las otras partes de la ciudad están virtualmente ausentes de sus representaciones. Para otros\/as inmigrantes, en cambio, esta demarcación de la ciudad incita a superar sus límites y a ir más allá de esas fronteras. Para estos\/as migrantes las referencias a espacios y áreas del norte de la ciudad resultan persistentes, se vuelven el motivo de muchas de sus narrativas y ordenan los propios modos de circular por la ciudad (o de intentar o de proyectar hacerlo). Las referencias a estas otras partes de la ciudad organizan sus representaciones sobre el espacio urbano y constituyen un elemento clave de sus deseos y sus búsquedas. Las dificultades enfrentadas para circular por la ciudad son puestas en términos de desigualdad de clase y de discriminación. Al mismo tiempo, las posibilidades efectivas de circular por ella son entendidas por estos migrantes en términos de recorridos en el espacio. Así, su historia migratoria habilita los desafíos a la ciudad demarcada y, a la vez, su experiencia urbana confirma una comprensión no in-migratoria de los desplazamientos espaciales. El desafío del artículo es aportar elementos para la comprensión de una 'categoría nativa' clave en este proceso: 'recorrido territorial' y, a través de ello, a portar a la comprensión del proceso mismo.","palabras_clave":"MIGRACIÓN|CIUDAD|DESPLAZAMIENTOS|FRONTERAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37258,"idioma_id":5,"titulo":"Propuesta docente para la asignatura Organización de Computadoras - Lic. en Ciencias de la Computación","resumen":"Resumen. Este artículo presenta las experiencias en la asignatura ?Organización De Computadoras? correspondiente al grado en Licenciatura en Ciencias de la Computación. La asignatura estudia principalmente la frontera software-hardware de las computadoras, su estructura básica, funcionamiento y programación en lenguaje ensamblador. El objetivo de este trabajo es mostrar la propuesta didáctica empleada, que intenta solucionar los inconvenientes presentados por la metodología previamente utilizada: ausencia de relación entre la programación de alto y bajo nivel que producía problemas al alumno para comprender otras asignaturas, y dificultad para detectar las causas de los errores que los alumnos cometían en los exámenes. La solución se basa en el diseño de actividades de enseñanza y aprendizaje que promueven la comparación de ambos niveles de programación, y una novedosa metodología de evaluación con exámenes que intentan recrear un ambiente de trabajo profesional con múltiple información a disposición. Los resultados indican una mejoría en la calidad del aprendizaje alcanzado por los alumnos.","palabras_clave":"Enseñanza Organización de Computadoras| Enseñanza Estructura de Computadores"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37323,"idioma_id":5,"titulo":"El derecho a la educación en América Latina: sentidos históricos y perspectivas en disputa","resumen":"En el artículo se analizan diferentes perspectivas sobre el derecho  a la educación en la actual coyuntura en América Latina, desde tres  dimensiones. En primer término la conformación histórica de los derechos  asociados a las ideas de ciudadanía y de Estados-nación pensados en tanto  ?comunidades imaginadas? en tiempos formalmente homogéneos.   En  segundo término, las diferentes concepciones en disputa en torno al  derecho a la educación y las funciones asignadas al Estado y a los otros  agentes educativos en cada una de esas concepciones. Por último, las  viejas y nuevas políticas que buscan materializar el derecho a la educación  en un escenario tensionado entre la democratización y la mercantilización  del conocimiento.","palabras_clave":"EDUCACION|DERECHOS|ESTADO|AMERICA LATINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37332,"idioma_id":5,"titulo":"La reforma de la justicia de paz en la provincia de Buenos Aires a principios del siglo XX: ¿una agenda impostergable ante el cuestionamiento del sistema penal","resumen":"Este artículo se centra en los debates legislativos de la provincia de Buenos  Aires en las dos primeras décadas del siglo XX,  con el propósito de identificar las razones que obstruyeron las iniciativas  del Ejecutivo provincial tendientes a limitar la amplia competencia de la  justicia de paz en materia penal. Además de motivos económicos y políticos como marco explicativo de la inalterabilidad de esa institución en  su jurisdicción, el texto sugiere atender la incidencia que habría tenido el  contexto de preocupación generado por los efectos lesivos de la política  criminal. Ante el crecimiento de la población carcelaria y la rigurosidad  de la legislación penal sancionada en 1903, cobraría creciente gravitación la justicia de paz como una instancia clave de mediación.","palabras_clave":"JUSTICIA DE PAZ|INICIOS SIGLO XX|PROVINCIA BUENOS AIRES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37368,"idioma_id":5,"titulo":"Responsabilidad social minera y educación en Santa Cruz","resumen":"En los últimos años, producto de las crecientes demandas laborales del entorno, sobretodo en la  zona norte de Santa Cruz el Estado, las empresas mineras, los actores sociales vinculados a la actividad, proveedores, sindicatos  y  trabajadores demandan capacitación a corto plazo. Paralelamente la capacitación es una preocupación a ser incorporada en las políticas educativas  en el marco de la Educación Técnica y Formación Profesional. Esta última lejos de posicionarse como espectadora deberá tomar las riendas de transformar el mito en realidad ¿Cuál es la verdad de esta dimensión de la educación en Santa Cruz?","palabras_clave":"MINERÍA|EDUCACION|RSE|SANTA CRUZ"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37372,"idioma_id":5,"titulo":"Los 'bemoles' en la capacitación en la minería de Santa Cruz","resumen":"Presentación de algunas reflexiones acerca de las  razones que explican por qué a 17 años de desarrollo de la actividad productiva, todavía la demanda de trabajadores cualificados sigue siendo un pendiente del conjunto de los actores que viven de la misma.","palabras_clave":"MINERÍA|CAPACITACION|RSE|SANTA CRUZ"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37377,"idioma_id":4,"titulo":"Morphogenesis at tiller level of Panicum coloratum","resumen":"Panicum coloratum (Pc), perennial megathermic Poaceae, is an important feed resource for cattle breeding systems in the province ofSan Luis (Argentina). In a plot located in the experimental field of Agronomy in UNSL, after a clean cut, 20 tillers were identified indifferent plants with the objective of evaluate the morphogenetic behaviour of PC. Every seven days, appearance and senescence ofleaves and leaf length was recorded. The maximum number of accumulated leaves \/ tiller, mean leaf lifespan (VMF) and leaf appearancerate (TAH) was determined. VMF is considered as the days elapsed between the appearance of a leaf and the beginning of senescenceand TAH to the time interval (days) between the appearance of two successive leaves. Analyzed tillers were those that had the greatestnumber of fully expanded leaves (10). During the growth cycle, Pc accumulated 11 leaves distributed between the initial spring regrowthand two leaf parts in summer-autumn. On average, each leaves generation presented 4 ± 0.83 leaves. The fourth leaf (initial regrowth)reached an average 308 ± 73 mm maximum leaf length, the octave (first replacement) 458 ± 185 mm and the eleventh leaf (secondreplacement) 617 ± 108 mm. VMF was 73 ± 14 days and TAH 19 ± 4 days, calculated between the fifth and eleventh leaf. 40% of tillersremained vegetative. For the study environmental conditions, Pc provides, every 73 days, three leaves generations suitable for grazing.","palabras_clave":"a"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37380,"idioma_id":4,"titulo":"EFFECT OF ACCESSIBILITY TO DRINKING WATER ON THE BEHAVIOR OF GRAZING BREEDING COWS","resumen":"The variation solid excrement deposition of breeding cows was determined according to the distance from the watering points. The workwas conducted in four productive livestock establishment in San Luis, Argentina. Digitaria eriantha deferred pastures in a sandy area(400 ha), sandy grassland seeded with Eragrostis curvula and D. eriantha (700 ha), only sandy grassland (700 ha) and natural grasslandof ?bosque bajo de algarrobo? region in the southwest of de province (700 ha) paddock were used. Stratified sampling was performedconsidering the distance of watering points. The nearest sector was located at about 300-400 m, the medium sector at 1000-1700 m andthe furthest at 2200-3000 m from water point, according size of the pasture land. In each sector, three areas of 625 m2 were randomizeddemarcated. The variation in the number of dungs indicated that in the system with sandy grassland and cultivated species, in which thewatering point was bigger and more accessible (lagoon), fewer dungs were found in the nearest and furthest areas (both: 4.10 m2), andmore dungs (6.10 m2) in the middle sector indicating a larger animal presence. In the rest of the pastures (with man-made concretewatering point), a gradient of grass utilization was determined according to the distance to the watering point, denoting larger animalpresence in the near (variation according to system 0.11 to 1.85 \/ 10 m2) and less animal presence in the furthest area (range: 0.03-0.43 \/10 m2). Differences in the amount of dungs between systems are due to the intrinsic management characteristics of each one of them.","palabras_clave":"a"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37384,"idioma_id":5,"titulo":"Jóvenes que eligen su futuro en la quinta","resumen":"En esta oportunidad desde el equipo del Boletín Hortícola, decimos compartir el espacio de la entrevista con jóvenes, hijos de quinteros, que después de algunas experiencias vividas han decidido quedarse en la quinta, para su presente y su futuro.","palabras_clave":"JOVENES|AGRICULTURA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37387,"idioma_id":5,"titulo":"Me gustaría seguir teniendo charlas de remedios caseros, porque son más baratos y menos peligrosos para nosotros","resumen":"E esta oportunidad entrevistamos a MARTA GALVAN, productora hortícola familiar de 32 años, boliviana de Tarija, en octubre se cumplen 8 años que vino a la Argentina, más precisamente a La Plata, por falta de trabajo en su ciudad de origen. Mamá de Darío de 15 años, de Brisa de 11 años y de Abril de 10 meses; esposa de René.","palabras_clave":"REMEDIOS|CASEROS|AGRICULTURA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37400,"idioma_id":5,"titulo":"El digesto jurídico argentino y el derecho internacional. Críticas, reflexiones y propuestas","resumen":"La entrada en vigor del Digesto Jurídico Argentino instrumentado por la Ley 26.939 (sancionada el 21 de mayo de 2014 y publicada en el Boletín Oficial el 16 de junio de 2014) y que ?consolida el derecho vigente y no vigente? al 31 de marzo de 2013, amerita algunas advertencias sobre los riesgos que entraña para el sistema jurídico argentino y sus intérpretes. A pesar de destacar la encomiable labor desarrollada por el legislador y su eventual utilidad a título informativo o compilatorio, debe señalarse que la sanción del Digesto Jurídico Argentino ?con fuerza de Ley?, incurre en desaciertos, errores, omisiones e incongruencias que, con seguridad, serán cuestionadas o advertidas por la academia, los colegios profesionales de abogados y las organizaciones civiles sin fines de lucro orientadas a la administración de justicia y su accesibilidad, entre otras entidades.Es por ello que preocupan algunas de ellas que, particularmente, afectan gravemente a la rama del derecho más sensible del ordenamiento jurídico a partir de la reforma constitucional de 1994 y que se expondrán a continuación y a título enunciativo, incluyendo críticas, reflexiones y propuestas en la medida de lo posible.","palabras_clave":"Digesto Jurídico Argentino|Críticas|Propuestas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37415,"idioma_id":5,"titulo":"Una mirada desde el margen: el caso de la infanticida María Mancilla","resumen":"Este artículo reconstruye, desde el análisis microhistórico y una perspectiva de género, la experiencia de las mujeres que cometieron infanticidios en la provincia de Buenos Aires a principios del siglo XX. A través de la historia de vida de María Mancilla  indagaremos las tensiones y contradicciones que subyacieron en las discusiones de las sentencias judiciales de los casos de infanticidio, en las cuales las mujeres cuestionaron y resistieron la naturalidad promovida, desde el aparato estatal, del binomio madre-hijo. En el campo de las prácticas sociales es donde encontramos las resistencias y las tensiones que fueron más allá de los intentos de normalizar las ideas y las prácticas genéricas. De este modo, su experiencia recoge el carácter de agenciamiento de los sujetos no como individuos unificados ni autónomos sino más bien como sujetos cuya agencia se creó a través de las situaciones y el estatus que la sociedad les confirió.","palabras_clave":"infanticidio|historia de vida|genero"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37417,"idioma_id":5,"titulo":"La política social en la actualidad latinoamericana: ¿hacia una política asistencial ?pos-neoliberal","resumen":"En el escenario regional de principios de siglo XXI emergen gobiernos que establecen, en mayor o menor medida, un proceso de rupturas con buena parte de las políticas implementadas durante la hegemonía del denominado Consenso de Washington. El análisis de esta realidad, condujo a buena parte de la literatura especializada en el tema a caracterizar el actual período como ?pos-neoliberal? y, en este sentido, a las políticas públicas implementadas como ?pos-neoliberales?. En este contexto de debate, el objetivo del presente trabajo es indagar si es posible hablar de una política asistencial ?en tanto sector institucional especifico de la política social? ?pos-neoliberal?. Para construir una aproximación a la respuesta del interrogante, se analizan las características de las Transferencias Monetarias Condicionadas (TMC) que se instalan en las dos últimas décadas en un espacio medular de la política asistencial.","palabras_clave":"POLITICAS PUBLICAS|POLITICA ASISTENCIAL|POLITICA SOCIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37464,"idioma_id":5,"titulo":"Sellos de contemporaneidad en la construcción de perfiles docentes","resumen":"En este artículo se aborda la formación actual de los estudiantes del profesorado en Artes Plásticas con orientación en Grabado y Arte Impreso de la Facultad de Bellas Artes de la Universidad Nacional de La Plata. Se hace una interpretación de prácticas educativas concretas, que tienen como núcleo los impresos artísticos. Estas prácticas se inscriben en la perspectiva pedagógica constructivista y se relacionan con el arte contemporáneo.","palabras_clave":"ARTE CONTEMPORÁNEO|FORMACIÓN DOCENTE|CONSTRUCTIVISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37467,"idioma_id":5,"titulo":"La construcción de sentido a través del arte impreso. Operaciones discursivas.","resumen":"En este texto abordamos las características del arte contemporáneo que atraviesan a las prácticas de docentes y de estudiantes de la Cátedra de Grabado y Arte Impreso de la Facultad de Bellas Artes, de la Universidad Nacional de La Plata. En el marco de una investigación sobre el uso de tecnología digital para la producción de imágenes impresas, analizamos procesos creativos de cuatro estudiantes.Reconocemos estos procesos como tramas de las que emerge el lenguaje configurando sentido.","palabras_clave":"IMPRESOS|RECURSOS DIGITALES|DISCURSOS|PRÁCTICAS|SENTIDO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37493,"idioma_id":5,"titulo":"LINEAMIENTOS GENERALES DEL RÉGIMEN DE CAPACIDAD EN EL PROYECTO DE CÓDIGO CIVIL Y COMERCIAL DE LA NACIÓN.","resumen":"En los últimos años se han introducido modificaciones en el régimen jurídico de capacidad de ejercicio de la persona humana por vía de normas especiales, que en algunos casos derogan y sustituyen artículos del Código Civil mientras que otros mantienen su vigencia y provocan desajustes. Ello hace que resulte conveniente adecuar el Código al derecho supranacional, modificar sus disposiciones para incorporar los principios y normas contenidos en las leyes especiales mencionadas. El Proyecto de Código Civil y Comercial 2012 da respuesta a esos planteos. Las normas proyectadas en líneas generales establecen: en materia de capacidad la regla es la capacidad y la incapacidad la excepción, la capacidad de derecho no presenta modificaciones significativas solo adecuaciones; respecto a la capacidad de ejercicio, no hay un sistema rígido de capacidad-incapacidad, sino que el criterio es la flexibilidad. En cuanto a restricciones o incapacidad en razón de afecciones a la salud mental, se adoptan los principios generales de las normas internacionales referidas al tema, ya incorporados a la Ley 26.657, Ley Nacional de Salud Mental","palabras_clave":"CODIGO|CIVIL|COMERCIAL|CAPACIDAD|EJERCICIO|SALUD|MENTAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37531,"idioma_id":4,"titulo":"On the complexity of the Saccharomyces bayanus taxon: hybridization and potential hybrid speciation","resumen":"Although the genus Saccharomyces has been thoroughly studied, some species in the genus has not yet been accuratelyresolved; an example is S. bayanus, a taxon that includes genetically diverse lineages of pure and hybrid strains. Thisdiversity makes the assignation and classification of strains belonging to this species unclear and controversial. They havebeen subdivided by some authors into two varieties (bayanus and uvarum), which have been raised to the species level byothers. In this work, we evaluate the complexity of 46 different strains included in the S. bayanus taxon by means of PCRRFLPanalysis and by sequencing of 34 gene regions and one mitochondrial gene. Using the sequence data, and based onthe S. bayanus var. bayanus reference strain NBRC 1948, a hypothetical pure S. bayanus was reconstructed for these genesthat showed alleles with similarity values lower than 97% with the S. bayanus var. uvarum strain CBS 7001, and of 99?100%with the non S. cerevisiae portion in S. pastorianus Weihenstephan 34\/70 and with the new species S. eubayanus. Among theS. bayanus strains under study, different levels of homozygosity, hybridization and introgression were found; however, nopure S. bayanus var. bayanus strain was identified. These S. bayanus hybrids can be classified into two types: homozygous(type I) and heterozygous hybrids (type II), indicating that they have been originated by different hybridization processes.Therefore, a putative evolutionary scenario involving two different hybridization events between a S. bayanus var. uvarumand unknown European S. eubayanus-like strains can be postulated to explain the genomic diversity observed in our S.bayanus var. bayanus strains.","palabras_clave":"SACCHAROMYCES EUBAYANUS|SACCHAROMYCES PASTORIANUS|YEAST|DIVERSITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37653,"idioma_id":5,"titulo":"Tendencias actuales y transformaciones incipientes en China: sus implicancias para las economías latinoamericanas","resumen":"Desde su proceso de reformas y apertura económica en los años ´90 China ha adquirido un creciente protagonismo en la economía global. Su inserción internacional se basó en el ensamble de productos en general intensivos en mano de obra que son exportados a los principales centros industriales y otros países de desarrollo intermedio. Actualmente, China se encuentra, de manera incipiente, en una fase de cambio de su patrón de crecimiento. El objetivo de la presente nota es señalar ciertos rasgos de este cambio, identificar algunas tendencias y regularidades que se vienen manifestando en la economía china, y paralelamente resaltar qué impactos se observan de estos procesos en los países de América Latina.","palabras_clave":"China |América Latina|Comercio exterior"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37661,"idioma_id":4,"titulo":"Methane dry reforming over sol-gel Rh-Al2O3 catalyst","resumen":"The gas phase dry reforming of methane with carbon dioxide on a sol-gel Rh-Al2O3 catalyst was investigated in a integral reactor operating at atmospheric pressure and temperatures between 550 and 650°C. The catalyst was characterized by BET, XRD, XPS, SEM, TEM and TPR. The catalyst exhibited promising activity, very good stability at variable methane and carbon dioxide feed and high carbon formation resistance. The kinetics was modelled with an empirical power-law rate expression. The results revealed that the reforming kinetics is of the order 0.6 with respect to methane and 0.4 with respect to carbon dioxide at the actual temperature interval. The apparent activation energy was 77.3 kJ\/mol.","palabras_clave":"DRY REFORMING OF METHANE|Rh-AL2O3 CATALYST|KINETICS|HYDROGEN|SYNTHESIS GAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37665,"idioma_id":4,"titulo":"Simulation of a Membrane Reactor for the Catalytic Oxydehydrogenation of Ehylbenzene to Styrene","resumen":"The steady-state simulation of a multitubular membrane reactor for styrene productionby ethylbenzene oxidehydrogenation is presented. A one-dimensional heterogeneousmodel is used.By means of detailed mathematical model, internal and global effectiveness factors areevaluated. For multicomponent gas mixture, Steffan-Maxwell equations are used tocompute external and internal mass transfer.Inside the porous catalytic pellets, Dusty-Gas model is applied to describe simultaneousmulticomponent diffusion and chemical reaction [1]. Orthogonal Collocations withoutsymmetry [2] are adopted to solve this type of model.Predicted effectiveness factors are relatively low. However, ethylbenzene conversion andstyrene selectivity are higher than those achieved employing the pseudo-homogeneousmodel.","palabras_clave":"CATALYSIS|MEMBRANE REACTOR| HETEROGENEOUS MODEL| PARTIAL OXIDATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37668,"idioma_id":4,"titulo":"Development of Ni-Rh-Al Catalysts for Methane Dry Reforming. Influence of the Method of Preparation","resumen":"The influence of the preparation method of the nickel-rhodium-aluminum based catalyst on its  microstructure and catalytic activity for methane carbon dioxide reforming was studied. Aluminum sec-butoxide, Ni 1-metoxi 2-propoxide and rhodium nitrate were used as starting reactants. Three catalysts were prepared by the main methods: i) hydrolysis and thermal decomposition (TD), ii) hydrolysis and acid peptization (sol-gel, SG) and iii) hydrolysis, thermal decomposition and hydrothermal treatment (TD-HT). The three catalysts were evaluated for a period of 30 hours with the same metallic composition, 14% Ni, 1.4% Rh and the same operating conditions namely temperature, 790 ºC; W\/FºCH4,in (relationship between mass of catalyst and the flow of methane in the feed stream), 0.5 g.h.mol-1 and CO2:CH4 ratio 1.0. The best bulk catalyst identified was (Ni-Rh-Al)TD-HT, showing excellent activity, selectivity, and stability. On the other hand the catalyst (Ni-Rh-Al)TD-HT was analyzed in a fixed bed reactor, modifying initial conditions such as  emperature, W\/FºCH4,in and CO2:CH4 ratio for a period of 120 hours achieving excellent catalytic activity, selectivity and stability. Studies on all catalysts evaluated reveal a low filamentous-type carbon deposition.","palabras_clave":"CO2 REFORMING OF METHANE|Ni- Rh-AL2O3 CATALYSTS|SYNTHESIS GAS|HYDROGEN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37685,"idioma_id":4,"titulo":"NLP model-based optimal design of LiBr-H2O absorption refrigeration systems","resumen":"This paper addresses the optimization of a single effect absorption refrigeration system operating with lithium bromide-water solution. A non-linear programming mathematical model is developed to determine the operating conditions and the distribution of the total heat transfer area (sizes) along the involved process units to optimize the following two objective functions: (i) maximization of the coefficient of performance for a given amount of the total heat transfer area, and (ii) minimization of the total heat transfer area of the system for a given cooling capacity. The proposed model can either be used for simulation or optimization purposes. Simulated or optimized values of temperature, pressure, composition and flow rate of all streams and sizing of each process unit are predicted. In addition, because of the non linear nature of the resulting model, a systematic solution procedure is proposed in order to guarantee the model convergence. A detailed discussion of the optimization results are presented through different case studies.","palabras_clave":"LiBr \/H2O ABSORPTION REFRIGERATION SYSTEMS |OPTIMAL DESIGN|MATHEMATICAL PROGRAMMING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37699,"idioma_id":5,"titulo":"Sobre la presencia y situación de conservación de Cyathea delgadii (Cyatheaceae) en la Argentina","resumen":"Information on a small population of Cyathea delgadii (Cyatheaceae) founded in Corrientes Province, Argentina, is presented. The presence of this species in our country was in doubt after raising the height of the dam Yacyretá","palabras_clave":"Nuevos registros|Helecho|Corrientes|Flora"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37702,"idioma_id":4,"titulo":"Novelties in Oxypetalum (Apocynaceae-Asclepiadoideae) for the Argentine Flora","resumen":"Including the results reported in this paper, there are 41 species of Oxypetalum (Apocynaceae, Asclepiadoideae) that occur in Argentina, eight of them endemic: O. arenicola, O. fontellae, O. gracile, O. lynchianum, O. longipedunculatum, O. pubescens, O. tucumanense and O. teyucuarense. The last is a new species from the Paraje Teyú Cuaré, San Ignacio, Misiones Province, Argentina, which is described and illustrated here. It shares some morphological features with O. jorgensenii, but, overall, it does not closely resemble any other species of the genus morphologically in its unique assemblage of characteristics. In addition to this new species, we here report two additional species for the first time in Argentina","palabras_clave":"Nuevos registros|Misiones|Asclepiadaceae|Apocynaceae"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37739,"idioma_id":5,"titulo":"Partidos políticos, campañas electorales y comicios en un momento fundacional: el triunfo de la Unión Cívica Radical de Santa Fe (1912)","resumen":"El trabajo se propone analizar el escenario que hizo posible el triunfo electoral de la Unión Cívica Radical de Santa Fe (UCRSF) en 1912, año de la reforma política llevada a cabo por el gobierno nacional. El triunfo electoral implicó convertir a la provincia de Santa Fe en el primer distrito electoral gobernado por el radicalismo, partido con un pasado revolucionario pero también proclive a los acuerdos con facciones conservadoras. El análisis de las estrategias electorales, las movilizaciones, la definición de las candidaturas y los diferentes vínculos con las demás organizaciones partidarias, son algunos de los caminos que se recorrerán para dar cuenta del acceso al poder de un partido que ejercerá uno de los protagonismos más relevantes del siglo XX.","palabras_clave":"SANTA FE|PARTIDOS POLITICOS|MOVILIZACIONES|ELECCIONES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37742,"idioma_id":5,"titulo":"La fortaleza de la palabra pública. Evocación a Darío Macor","resumen":"En el camino de la experiencia comunicacional, para aquellos que hacemos de la escritura parte de nuestro oficio, la página en blanco se presenta como una perseverante compañera. Nunca resulta sencillo el diseño de un texto, y más todavía cuando el mismo hace referencia a quien ya no está. Y así como el complejo arte de escribir se aprende con su ejercicio, la dedicación y la paciencia, un texto que pretende evocar a Darío Macor se puede experimentar sólo en esta única circunstancia.","palabras_clave":"DARIO MACOR|INTELECTUALES|HISTORIADORES|UNIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37748,"idioma_id":5,"titulo":"Aproximaciones al campo de la pedagogía social en la Argentina","resumen":"Este trabajo propone un acercamiento a las reflexiones  sobre la conformación del campo de la pedagogía  y educación social en Argentina, sin pretensión  de exhaustividad. Dibuja una línea extensa, respecto  a los largos discursos sobre las infancias pobres y su  nominación como niños a principios del siglo XX y su  exclusión del dispositivo escolar para ser incluidos, ya  desde el siglo XIX, como objeto de las primeras acciones  sociales con rasgos benéficos. Se sitúa la relación  entre lo social y lo educativo como una tensión que  se produce en un campo de disputa. En Argentina, a  partir del la crisis del 2001 con la caída de millones  de personas en una situación de pobreza extrema,  indigencia y exclusión, se produjo un estallido de experiencias  educativas a cargo de diferentes actores  sociales y políticos que superaron las fronteras del  sistema escolar. La formalización de la carrera de Tecnicatura  Superior en Pedagogía y Educación social  por parte del Ministerio de Educación de la Nación  abre una nueva etapa de consolidación de este campo  en nuestro país todavía en construcción.","palabras_clave":"Educación social|pedagogía|pobreza|formación|escuela publica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37760,"idioma_id":5,"titulo":"¿Cuántos significados tiene un producto?","resumen":"El marketing esencial se basa en la determinación de los significados en la mente del consumidor y de los códigos en la mente del mercado. Para poder sustentar esto se han creado metodologías como las técnicas de afloramiento de significado y las técnicas proyectivas entre otras. Pero, el nuevo problema que surge de esta conceptualización teórica es si vamos a poner al significado en la base del plan de marketing, la pregunta es ¿cuántos significados se deben determinar? Por lo que sabemos cada cultura tiene sus propias significaciones y los significados también cambian con el tiempo incluso lo hacen contextualmente. Lo cual hace aún más complejo el dilema presentado como título de este artículo. En se presentan los argumentos teóricos que sustentan uno de los descubrimientos más importantes del marketing esencial que sostenemos: en general para cada producto o servicio hay cuatro significados dominantes. ","palabras_clave":"SIGNIFICADO|PRODUCTO|CODIGOS|POSICIONAMIENTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37764,"idioma_id":5,"titulo":"Los cuatro aspectos esenciales por investigar","resumen":"El marketing tradicional angloamericano ofrece una metodología de investigación de mercados, simple, aunque no esencial. El costo de asumir esta metodología ha dejado un lamentable saldo del 85% de probabilidad de fracasos de los planes de marketing lanzados en los mercados de la actualidad. Es de esperarse que esta situación sea inadmisible para las empresas de los mercados latinoamericanos, ya que por su estrecha magnitud de sus mercados y la poca inserción internacional, están obligadas a mejorar notablemente su performance investigativa e ir a las cuestiones de fondo, para sentar los cimientos sobre los que se debe apoyar su plan de marketing. En este artículo se presentan los nueve niveles de investigación y se promueven técnicas de investigación alternativas que están cambiando los resultados de los planes de marketing que hemos denominado esencial.","palabras_clave":"percepción|significado|código|arquetipo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37767,"idioma_id":4,"titulo":"A Posteriori Error Estimates of stabilized Low-Order Mixed Finite Elements for the Stokes Eigenvalue Problem","resumen":"In this paper we obtain a priori and a posteriori error estimates for stabilized low-ordermixed finite element methods for the Stokes eigenvalue problem. We prove the convergence of the method and a priori error estimates for the eigenfunctions and the eigenvalues. We define an error estimator of the residual type which can be computed locally from the approximate eigenpair and we prove that, up to higher order terms, the estimator is equivalent to the energy norm of the error. We also present some numerical tests which show the performance of the adaptive scheme.","palabras_clave":"Stokes eigenvalue problem|stabilized mixed methods|a posteriori error estimates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37777,"idioma_id":5,"titulo":"Los médicos anarquistas antifascistas y el control de la natalidad. Los  puentes intertextuales sobre el Atlántico. España y Argentina (1920-1940)","resumen":"A través de los pioneros estudios de Mary Nash sobre la Reforma Sexual y la Reforma Eugénica en España pudimos conocer el papel de los médicos anarquistas Isaac Puente y Félix Martí Ibáñez en la difusión de las ideas de control de la natalidad, maternidad consciente y libertad sexual, en particular, durante la Segunda República.   Sus ideas difundidas a través de las revistas Generación Consciente y Estudios nos permiten establecer vínculos con las ideas de dos médicos anarquistas antifascistas de Argentina. Nos referimos a Juan Lazarte y Manuel Martín Fernández. Sus ideas, difundidas en revistas anarquistas y en publicaciones propias, se acercaban a las perspectivas de los médicos españoles.   En este trabajo nos interesa indagar aquellos puentes intertextuales que se establecieron entre los médicos ácratas, las influencias del pensamiento de los médicos españoles en las narrativas de los médicos locales, así como las divergencias. Indagaremos las ideas sobre el control de la natalidad, sustentada en el pensamiento eugénico anarquista. Estas ideas las hemos relevado en la producción local de los médicos, las cuales entendemos, evidencian el carácter internacionalista del movimiento. Los intercambios y las influencias no sólo se produjeron en la dimensión de las ideas, sino que durante la guerra civil española, estos médicos participaron activamente en la delegación argentina de Solidaridad Internacional Antifascista.","palabras_clave":"DISCURSO MÉDICO|CONTROL DE LA NATALIDAD|ANARQUISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37779,"idioma_id":5,"titulo":"La maternidad consciente y voluntaria como estrategia para la emancipación sexual femenina.","resumen":"En el presente trabajo, nos proponemos analizar la propuesta de maternidad consciente y voluntaria promovida  por los médicos anarquistas. Vinculada y analizada como parte de la propuesta política y eugénica primordialmente, en la mayoría de las investigaciones ,no se profundizó en otras relaciones. Podemos decir que la propuesta de maternidad consciente  y voluntaria coadyuvó a configurar un discurso que promovió la emancipación femenina en cuanto a la capacidad de las mujeres para decidir sobre su cuerpo y su sexualidad. Uno de los aportes centrales fue la diferenciación entre la reproducción y el placer sexual. El reconocimiento que el sexo podía estar asociado al placer y no a la reproducción habilitó la posibilidad de reflexionar en la posibilidad de tomar medidas para evitar embarazados no deseados.","palabras_clave":"MATERNIDAD|ANARQUISMO|EMANCIPACIÓN SEXUAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37783,"idioma_id":5,"titulo":"EXPLOTACIÓN DE PECES EN LAGUNAS DE GUANACACHE. ALTOS DE MELIÉN II","resumen":"Hasta recientemente la investigación zooarqueológica del centro occidente se focalizó en la importancia de los mamíferos grandes, principalmente camélidos. Existe relativamente abundante información etnohistórica que ilustra la importancia de la explotación de peces en las lagunas de Guanacache para momentos históricos. Sin embargo -salvo contadas excepciones- el registro zooarqueológico ha sido poco explorado en relación a este tema, a pesar de encontrarse abundantes restos de peces en distintos sectores de la planicie. En este trabajo se analizan los datos obtenidos a partir de los restos de peces recuperados en el sitio Altos de Melién II, sector I (Guanacache, Mendoza) y se los compara con aquellos provenientes de otros conjuntos arqueológicos recuperados en contextos cercanos, con el objetivo de avanzar sobre el conocimiento del consumo de peces en esta zona del NE de Mendoza, atendiendo especialmente a los potenciales procesos de formación que inciden en este tipo de conjuntos.   El registro ictioarqueológico en AM II presenta un predominio de restos pertenecientes a perca criolla (Percichthys trucha), aunque se han identificado también especimenes de pejerrey patagónico (Odontesthes hatcheri). Analizando la representación de los segmentos corporales y otros indicadores, se sugiere que el registro es producto principalmente del descarte de aquellas partes no consumibles para un aprovechamiento ligado a la subsistencia humana.","palabras_clave":"EXPLOTACIÓN DE PECES|ICTIOARQUEOLOGÍA|TAFONOMÍA|MENDOZA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37807,"idioma_id":4,"titulo":"PHYTOPLANKTONIC COMPOSITION AND WATER QUALITY OF A IN NORTHWESTERN ARGENTINA","resumen":"PHYTOPLANKTONIC COMPOSITION AND WATER QUALITY OF A RIVER NORTHWEST ARGENTINATaboada, MÁ1,2, Martínez De Marco, S2,3, Tracanna, BC1-3, Mirande, V2,3 & Isasmendi, S31CONICET, 2IFico-FML,3ILINOA-FCN e IML?UNT. Miguel Lillo 205. mariataboada@live.comThe orographic conditions and climate of the Argentinian Northwest allow the existence of numerous aquatic, Tucumán has an extensive hydrographic. The river Las Moras is a tributary of Escaba Reservoir. The study area is located in the Yungas, the climate is temperate, with rainy summers. The objective was to evaluate the temporal and seasonal variation of phytoplankton and their relationship with the quality of the water in the mouth of the river. Seasonal samples were taken (august\/10-march\/12) and the variables considered were: pH, conductivity (EC), dissolved oxygen (DO), biochemical oxygen demand (BOD5), major ions, nitrogen and total phosphorus, species richness, abundance, biomass and algal diversity. The samples were collected according to standard methodology. The water was characterized as calcium-sodium-bicarbonate alkaline and oxygenated. Nitrogen and phosphorus total reached records of 10 mg\/l (march\/12) and 0.56 mg\/l (march\/11). Conductivity fluctuated between 89-130 µS\/cm, the BOD5 varied between <5-46 mg\/l. We identified 25 species phytoplanktonic represented by: Bacillariophyceae (14), Chlorophyta (6), Cyanophyta (2) Euglenophyta (2) and Dinophyta (1). The biomass fluctuated between 23-1379 chlorophyll a\/l. In march\/11 was recorded the highest algal abundance (1441 ind\/ml). The specific diversity ranged from 0.12 (march\/11) and 1.93 (august\/10). It is highly significant correlations were found between EC with nitrate and with OD, between pH and BOD5, total phosphorus with biochemical oxygen demand, OD and nitrate. During the winters of 2010-11 was noted the greater richness and diversity specific, because of the contribution of diatoms. The input of nutrients in the summer of both years, favored the development of Ceratium hirundinella which determined an increase in the density and phytoplankton biomass","palabras_clave":"PHYTOPLANKTON|WATER QUALITY|ESCABA RESERVOIR|CERATIUM HIRUNDINELLA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37814,"idioma_id":5,"titulo":"Poder para prever, los pronósticos y el uso de la prisión preventiva","resumen":"En este trabajo se analizará, a  partir del uso de la prisión preventiva, la relación que existe entre los peligros  procesales que pueden justificarla y los pronósticos a partir de los cuales se  los anticipa. Junto a esto, describiremos desde 1998 -año en que se reformó  estructuralmente el Código Procesal Penal de la provincia de Buenos Aires- los  cambios que se han dado respecto a la regulación de la prisión preventiva y las  excarcelaciones. Por último, exhibiremos los testimonios de los actores  judiciales sobre ambos temas, para enriquecer el análisis sobre la aplicación  de la medida cautelar.","palabras_clave":"prisión |preventiva|pronósticos |conocimiento"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37816,"idioma_id":5,"titulo":"Por escrito: El uso de la prisión preventiva en los expedientes","resumen":"En este artículo, continuando otro trabajo realizado sobre la misma problemática, mencionaremos las características del objeto expediente. Luego, tomando este instrumento como fuente primaria, analizaremos a partir de cuatro  modelos de argumentación aquello que se consigna para justificar la medida  cautelar.","palabras_clave":"prisión preventiva|expedientes|modelos|argumentación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37819,"idioma_id":5,"titulo":"Formación Profesional en Santa Cruz Norte: ?Entre el ser y el deber ser?","resumen":"En la educación formal, uno de los niveles más discutido y cuestionado, pero a la vez más demandado parece ser la Formación Profesional (FP). Este se proyecta con una fuerza prometedora, pero sin embargo a pocos años de haberse sancionado la Ley de Educación Técnica Profesional que la cobija, la misma aún se debate entre lo debería ser y lo que está siendo. En la presente nota se proponen algunos puntos de reflexión crítica para una agenda que reclama profesionalizar el nivel en la Provincia de Santa Cruz.","palabras_clave":"FORMACION|PROFESIONAL |EDUCACION|SANTA CRUZ"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37876,"idioma_id":5,"titulo":"Deficiencia crónica de andrógenos y efecto sobre el pulmón","resumen":"    Los andrógenos juegan un importante rol en la función pulmonar. Sumado a ello hemos encontrado que la castración afecta marcadamente la histoarquitectura pulmonar a tiempos cortos e incrementa el estrés oxidativo. El objetivo de este trabajo fue estudiar el efecto de la castración sobre el balance  prooxidanteantioxidante y sus manifestaciones en la estructura del pulmón en un proceso crónico. Ratas macho de la cepa Wistar (200 ± 20 g) fueron separadas en tres lotes: controles (Co), castradas (Ca) y el grupo de ratas castradas a las que se les administró Testosterona (Ca+T) los cinco días previos al sacrificio. A los 60 días se procedió a la extracción de los pulmones, se obtuvo ARN total y se realizó RT-PCR para el RA, Nrf-2, y NOX2; empleando como control interno S28. Se obtuvieron lavados broncoalveolares (LBA) y se realizó el recuento de células. Se determinó el grado de lipoperoxidación por cuantificación de TBARS y se midió la actividad de Catalasa (CAT). Se analizaron también cortes histológicos de pulmón a los cuales se los tiñó con Hematoxilina-Eosina. En Ca se observó un aumento de linfocitos y neutrófilos en el LBA, mientras que en Ca+T los polimorfonucleares disminuyeron con respecto a Co. Los niveles de TBARS bajaron en el grupo Ca+T (p&lt;0,001), mientras que la actividad de CAT no se modificó. RA aumentó significativamente en Ca (p&lt;0,005) y nrf-2 aumentó significativamente en Ca+T (p&lt;0,05) y NOX2 disminuyó significativamente en Ca (p&lt;0,01). La histología reveló infiltración de polimorfonucleares en el parénquima pulmonar y espacios alveolares expandidos, en Ca, mientras que en Ca+T la infiltración fue menor. Nuestros resultados demuestran que la ausencia crónica de andrógenos altera el balance oxidantes-antioxidantes, situación que se ve reflejada también a nivel de la histoarquitectura pulmonar como un proceso inflamatorio crónico. El suministro de testosterona mejora en algunos aspectos el panorama fisiológico del órgano.   ","palabras_clave":"ANDROGEN |LUNG"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37881,"idioma_id":5,"titulo":"Crisis y venta de grandes empresas en Argentina. El caso de Alpargatas en los años ´90.","resumen":"Un intenso proceso de extranjerización de grandes empresas ha tenido lugar en Argentina desde 1990. Este artículo analiza el caso de la desnacionalización de la empresa Alpargatas, ocurrida en 1999. Se concluye que la interrupción en el acceso a crédito local e internacional,la recesión doméstica e internacional y la agudización de la competencia en los años finales de la década cumplieron un papel determinante en la extranjerización. Las ventajas comerciales y financieras con que dicha firma contó al principio de la década no alcanzaron para evitar su crisis.","palabras_clave":"grandes empresas|extranjerización|crisis financiera|competitividad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37926,"idioma_id":5,"titulo":"Convergencia de paradigmas biotecnológicos y estrategias de los grupos líderes mundiales","resumen":"El propósito de este trabajo es analizar la diversificación tecnológica de las grandes firmas frente a la emergencia de nuevos paradigmas tecnológicos. A partir de la sistematización de una base de datos de patentes, este trabajo se pregunta por un lado, si estos procesos dan lugar a la convergencia entre las bases de conocimiento y la emergencia de un nuevo paradigma de biotecnología industrial. Por el otro, se discute a partir de datos de los principales grupos a nivel internacional si la mencionada diversificación da lugar a una base de conocimientos coherentes o es simplemente una expansión conglomeral, existiendo aun posibilidades de entrada para firmas de países en desarrollo.","palabras_clave":"Biotecnología | Diversificación |Paradigma tecnológico|Coherencia tecnológica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37929,"idioma_id":5,"titulo":"Transecta altitudinal en la Sierra de Famatina- Sitios GLORIA: Instalación ? Talleres ? Avances y Perspectivas","resumen":"ABSTRACT La Sierra de Famatina, con una altura máxima cercana a 6100 m, pertenece a las Sierras Pampeanas y es la montaña extra-andina más alta de Sudamérica. Se ubica en el centro-oeste de la provincia de La Rioja, oeste de Argentina.  Las Sierras Pampeanas están aisladas de la Cordillera de los Andes y son geológicamente distintas y considerablemente más antiguas  1.- Instalación de cuatro cimas de monitoreo GLORIA (Línea base) en 2011.   Se registraron un total de 175 especies de plantas vasculares en 122 géneros y 45 familias, además de 63 especies no vasculares (UNdeC).  Se está avanzando en la determinación taxonómica.  2.- Muestreo de insectos  Se utilizaron trampas amarillas para la captura de insectos voladores. Se colocaron 4 trampas cada 5m, siguiendo las cuatro orientaciones, a partir de la línea de 10 metros debajo de cumbre.   Material en procesamiento (UNdeC).  3.- Muestreo de aves.  Se realizaron observaciones e identificación de cantos siguiendo las cuatro orientaciones por 300m (GLORIA) y en quebradas, peñascos y arroyos. Se realizaron observaciones con binoculares e identificación de cantos.   Se registraron 30 especies pertenecientes a 11 familias. (UNdeC)  4.- Inventario florístico.  Más allá de áreas cimeras (UNdeC ? INTA, Instituto Nacional de Tecnología Agropecuaria). En proceso.  5.- Instalación de registradores de temperatura en 5 cimas (UNdeC ? Pacific Biodiversity Institute).    Área de Estudio  A: Mapa de los sitios GLORIA en Argentina.  B: Transecta altitudinal de la Sierra de Famatina a Sierra de Velasco mostrando los sitios GLORIA y MARAS.  Imágenes insertas: cimas GLORIA, altitud y forma del área cimera.    6.- Realización del ?III Taller Internacional del Monitoreo de Cambio Climático en Latinoamérica con Metodología GLORIA extendida? (UNdeC ? FONCyT- CONDESAN) con 31 participantes de 8 países y 5 provincias argentinas.","palabras_clave":"SA. DE FAMATINA|MONITOREO GLORIA|TRANSECTA ALTITUDINAL|LA RIOJA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37959,"idioma_id":4,"titulo":"Functionalization of nanochannels by radio-induced grafting polymerization on PET track-etched membranes","resumen":"The application of swift-heavy ion bombardment to   polymers is a well-established technique to manufacture micro- and   nanopores onto polymeric films to obtain porous membranes. A few years   ago, it was realized that, during ion bombardment, the high energy   deposition along the ion path through the polymer reached cylindrical   damage regions corresponding to the core trace and the penumbra. After   the etching procedure, there are still enough active sites left in the   penumbra that can be used to initiate a polymerization process   selectively inside the membrane pores. In this study,   we report the grafting polymerization of glycidyl methacrylate onto   etched PET foils to obtain functionalized nanochannels. Grafted polymers   were labeled with a fluorescent tag and analyzed by different   fluorescence techniques such as direct fluorescence, fluorescence   microscopy and confocal microscopy. These techniques allowed identifying   and quantifying the grafted regions on the polymeric foils.","palabras_clave":"NANOCHANNEL  FUNTIONALIZATION|FLUORESCEIN|CONFOCAL MICROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37960,"idioma_id":4,"titulo":"Responses of biomarkers of a standardized (Cyprinus carpio) and a native (Pimelodella laticeps) fish species after in situ exposure in a periurban zone of Luján River (Argentina)","resumen":"The Luján River basin, which is located in the northwest area of the province of Buenos Aires, Argentina, receives different anthropogenic inputs before reaching the Río de la Plata estuary. The aim of this study was to assess the adverse impact of the river in the middle part of the basin. To this end, an in situ cage assay was conducted in two sites of the river (S1 and S2) near Luján city, and the responses of hepatic biomarkers of both a standardized (Cyprinus carpio) and a native (Pimelodella laticeps) species were evaluated. The biomarkers studied were the condition factor and liver somatic indices (LSI), the enzymatic activities of catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST), lipid peroxidation levels (thiobarbituric acid reactive substances, TBARS) and the induction of hepatic cytochrome P450 1A (CYP1A) and vitellogenin (Vtg) proteins. After 14 days, LSI and GST activity increased, and TBARS levels decreased in both species exposed at S1 and S2. In addition, exposure at both sites promoted an increase in SOD activity and CYP1A induction in C. carpio, while Vtg expression was observed only at S1. A shorter exposure period (7 days) caused an initial response only at S2 mediated only by CAT in P. laticeps. Finally, our results demonstrate that a 14-day period of in situ exposure in Luján River could lead to antioxidant and biotransformation processes in C. carpio and to phase II biotransformation responses in P. laticeps. © 2012 Wiley Periodicals, Inc. Environ Toxicol, 2012.","palabras_clave":"BIOCHEMICAL AND MOLECULAR BIOMARKERSrs |CYPRINUS CARPIO AND NATIVE FISH SPECIES|FIELD CAGING ASSAY |PERIURBAN LUJÁN RIVER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37961,"idioma_id":4,"titulo":"4G\/5G plasminogen activator inhibitor-1 and -308 A\/G tumor necrosis factor-&#945; promoter gene polymorphisms in Argentinean lupus patients: focus on lupus nephritis.","resumen":"We investigated the relationship between the 4G\/5G plasminogen activator inhibitor (PAI-1) and -308 A\/G tumor necrosis factor-&#945; (TNF-&#945;) polymorphisms and the clinical and biochemical features of systemic lupus erythematosus (SLE) in an Argentinean patient cohort. A total of 402 patients were studied, including 179 SLE patients and 223 healthy individuals. PCR-RLFP was used to determine the genotypes of the 4G\/5G PAI-1 and -308 A\/G TNF-&#945; polymorphisms. SLE patients with lupus nephritis (LN) (n = 86) were compared with patients without LN (n = 93). Additionally, LN patients were divided into proliferative LN and non-proliferative LN groups according to the results of the renal biopsies. No significant differences were noted in the genotype distributions or allele frequencies of these TNF-&#945; and PAI-1 polymorphisms between SLE patients and controls. There were higher numbers of criteria for SLE, more lupus flares and higher damage scores in LN patients, but there were similar frequencies of anti-phospholipid antibody (APA) positivity and anti-phospholipid syndrome. No significant difference was noted for any studied variable between the proliferative LN and non-proliferative LN groups except for the presence of APA. We found no significant differences in the TNF-&#945; and PAI-1 genotype distributions or allele frequencies between groups. We found that the -308 A\/G TNF-&#945; and 4G\/5G PAI-1 polymorphisms are not associated with susceptibility to SLE in an Argentinean population. We also did not find any association between the presence of any specific allele or genotype and the development of LN in SLE patients. Finally, no association was noted between either of the two polymorphisms and the severity of renal disease","palabras_clave":"LUPUS|POLIMORFISMOS|NEFRITIS|PAI-1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37962,"idioma_id":4,"titulo":"Typification of virulent and low virulence Babesia bigemina clones by 18S rRNA and rap-1c","resumen":"    The  population structure of original Babesia bigemina isolates and reference strains with a defined    phenotypic  profile was assessed using 18S rRNA and rap-1c genes. Two reference strains,  BbiS2P-c    (virulent)  and BbiS1A-c (low virulence), were biologically cloned in  vitro. The virulence profile of the    strains  and clones was assessed in vivo. One fully virulent and one low-virulence clone were mixed in    identical  proportions to evaluate their growth efficiency in  vitro. Each clone was differentiated by two    microsatellites  and the gene gp45. The 18S  rRNA and rap-1c genes sequences from B. bigemina biological    clones  and their parental strains, multiplied exclusively in vivo  or in vitro, were compared with strain    JG-29.  The virulence of clones derived from the BbiS2P-c strain was variable. Virulent  clone Bbi9P1 grew    more  efficiently in vitro than did the  low-virulence clone Bbi2A1. The haplotypes generated by the    nucleotide  polymorphism, localized in the V4 region of the 18S  rRNA, allowed the identification of three    genotypes.  The rap-1c haplotypes allowed defining  four genotypes. Parental and original strains were    defined  by multiple haplotypes identified in both genes. The rap-1c gene, analyzed by high-resolution    melting  (HRM), allowed discrimination between two genotypes according to their  phenotype, and both    were  different from JG-29. B. bigemina biological clones made it possible to define the population    structure  of isolates and strains. The polymorphic regions of the 18S rRNA and rap-1c genes allowed    the  identification of different subpopulations within original B. bigemina isolates by the definition of    several haplotypes and the differentiation of fully  virulent from low virulence clones.  ","palabras_clave":"18S RRNA|BABESIA BIGEMINA|BIOLOGICAL CLONES|HRM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37963,"idioma_id":4,"titulo":"Identification and Assessment of water pollution as a consequence of a leachate plume migration from a Municipal landfill site (Tucumán, Argentina)","resumen":"Landfills constitute potential sources of different pollutants that could generate human health and environmental problems. While some landfills currently work under the protection of a bottom liner with leachate collection it was demonstrated that migration could take place even yet with these cautions. The purpose of this paper is to assess the pollution caused by a leachate plume from a municipal landfill that is affecting both ground-water and surface-waters. The research was carried out at Pacará Pintado landfill in northwestern Argentina. Analysis of water samples indicates that leachate is affecting groundwater under the landfill area and an abandoned river channel hydraulically connected. In the center of the landfill area the plume is anoxic and sulfate, nitrate, iron and manganese reduction zones were identified. Leachate plume presented high concentration of organic matter, Fe, Mn, NH4+, Cl- and Cr reaching an extension of 900 meters. The presence of a leachate plume in a landfill site with a single liner system implies that the use of this groundwater pollution control method alone is insufficient not enough especially if permeable sediments are present below.","palabras_clave":"Landfill|Leachate plume|Pollution|Tucumán"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37964,"idioma_id":4,"titulo":"Heparin binding analysis of boar sperm and its relation with farrowing capacity","resumen":"                        New methods for the evaluation of semen quality  according to in vivo reproductive  data are useful tools in terms to identify boars of lower fertility among  individuals with standard semen parameters. In this study, we evaluated by indirect fluorescence  microscopy the heparin-binding sites distribution  upon capacitation of sperm from eight boars arbitrarily distributed in  groups I and II according to differential farrowing rates (group I &#8805; 70%, group  II &lt; 70%). Additionally, the ability of sperm to bind to solubilized zona pellucida  (ZP) was assayed in the presence or absence of heparin. Samples of two  individuals of group II showed lower percentage of B pattern in relation to  other individuals (p &lt; 0.001). The number of spermatozoa attached to ZP after  2 hours of incubation in capacitating conditions with  heparin, was significantly lower than in its absence (p &lt; 0.0001). These results suggest that heparin-binding sites distribution concerning  capacitation may be indicative of the availability  of proteins involved in the fertilization process, specifically at the initial  sperm-oocyte recognition. Differences on heparin-binding sites dynamics during  capacitation may help identify a sub-population of individuals with lower  fertilizing capacity and normal spermiogram, which is particularly useful at high  production establishments.  ","palabras_clave":"Boar sperm|Farrowing rate|Heparin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37965,"idioma_id":4,"titulo":"Two different vestigial like 4 genes are differentially expressed  during Xenopus laevis development","resumen":"Vestigial gene (vg) was first characterized in Drosophila and several homologues were identified in vertebrates and called vestigial like 1-4 (vgll1-4). Vgll proteins interact with the transcription factors TEF-1 and MEF-2 through a conserved region called TONDU (TDU). Vgll4s are characterized by two tandem TDU domains which differentiate them from other members of the Vestigial family. In Xenopus two genes were identified as vgll4. Our bioinformatic analysis demonstrated that these two genes are paralogues and must be named differently. We designated them as vgll4 and vgll4l. In situ hybridization analysis revealed that the expression of these two genes is rather different. At gastrula stage both were expressed in the animal pole. However, at neurula stage vgll4 was mainly expressed at neural plate and neural folds while vgll4l prevail at neural folds and epidermis. From late neurula stage onward, expression of both genes was strongly enhanced in neural tissues, anterior neural plate, migrating neural crest, optic and otic vesicles. Nevertheless, there were some differences, vgll4 presented somite expression and vgll4l was localized at the skin and notochord. Our results demonstrate that Xenopus has two orthologues of vgll4 gene, vgll4 and vgll4l with differential expression in Xenopus embryos and probably they could have different roles during development.","palabras_clave":"VGLL4|EXPRESSION|ECTODERM|XENOPUS LAEVIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37966,"idioma_id":5,"titulo":"REGULACIONES A UNA DEVOCIÓN ESTIGMATIZADA :CULTO A SAN LA MUERTE EN BUENOS AIRES","resumen":"En este trabajo abordamos el culto a San la Muerte, santo popular oriundo de las provincias del litoral argentino con influencia guaranítica, y de gran expansión en la actualidad, a pesar de no ser reconocido por la Iglesia Católica. Esta devoción se hace presente en el espacio público y acrecienta su visibilidad en un marco de menor restricción estatal sobre los cultos. Este fenómeno se constata en la existencia de múltiples santuarios y altares a lo largo del país, su difusión en sitios web, santerías y en los medios de comunicación. Aún así, esta devoción continúa siendo estigmatizada y supone costos sociales para aquellos que le rinden culto. En este contexto, nos interesa abordar las diversas regulaciones estatales y sociales sobre este culto. En particular, haremos hincapié en la presentación que realizan los medios de comunicación (en el período 2008-2011) sobre esta devoción, la cual consideramos refuerza una imagen negativa y vinculada con el crimen en el imaginario colectivo. Por último, abordaremos las estrategias de legitimación que despliegan los encargados de santuarios a San La Muerte en Buenos Aires en tanto referentes de esta devoción popular.","palabras_clave":"Religiosidad Popular|Regulaciones|Legitimación|Medios de comunicación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37967,"idioma_id":4,"titulo":"Microwave assisted synthesis of pyrrolo [2,1-b] thiazoles linked to a carbohydrate moiety","resumen":"Herein, we describe the syntheses of 3,5-disubstituted imidazo[2,1-b]thiazole. The cyclization step was performed in two different conditions by using either thermal or microwave heating. Comparing the results of both methodologies, we found that the microwave assistance is an improved alternative to obtain this family of heterocyclic compound. Compounds were first evaluated for cytotoxicity in Vero cells by MTT method and then, the antiviral activity was assayed by a virus yield inhibition assay in the range of concentrations lower than the corresponding CC50, using JUNV strain IV4454 as the model system. The most active compounds (3 and 4), showed a level of antiviral activity against JUNV in monkey Vero cells better than the reference substance ribavirin. Then, they are promising lead compound for further analysis and characterization to establish their therapeutic potential against hemorrhagic fever viruses.","palabras_clave":"PYRROLO[2,1-b]THIAZOLES|CARBOHYDRATES|SYNTHESIS|MICROWAVE IRRADATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37968,"idioma_id":4,"titulo":"An extension of the Dirac and Gotay-Nester theories of constraints for Dirac dynamical systems","resumen":"Abstract. This paper extends the Gotay-Nester and the Dirac theories ofconstrained systems in order to deal with Dirac dynamical systems in theintegrable case. Integrable Dirac dynamical systems are viewed as constrainedsystems where the constraint submanifolds are foliated. The cases consideredusually in the literature correspond to a trivial foliation, with only one leaf. AConstraint Algorithm for Dirac dynamical systems (CAD), which extends theGotay-Nester algorithm, is developed. Evolution equations are written usinga Dirac bracket adapted to the foliations and an adapted total energy. Theinteresting example of LC circuits is developed in detail. The paper emphasizesthe point of view that Dirac and Gotay-Nester theories are, in a certain sense,dual and that using a combination of results from both theories may haveadvantages in dealing with a given example, rather than using systematicallyone or the other.","palabras_clave":"Dirac theory|Gotay Nester |Constraints|Dirac dynamical system"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37969,"idioma_id":4,"titulo":"On the isometry groups of invariant Lorentzian metrics on the Heisenberg group","resumen":"This work concerns the invariant Lorentzian metrics on theHeisenberg Lie group of dimension three H3(R) and the bi-invariantmetrics on the solvable Lie groups of dimension four. We start withthe indecomposable Lie groups of dimension four admitting bi-invariantmetrics and which act on H3(R) by isometries and we study some geometricalfeatures on these spaces. On H3(R) we prove that the propertyof the metric being proper naturally reductive is equivalent to the propertyof the center being non-degenerate. These metrics are Lorentzianalgebraic Ricci solitons.","palabras_clave":"pseudo-Riemannian spaces|naturally reductive spaces|Lie groups|Heisenberg Lie groups"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37970,"idioma_id":4,"titulo":"Isometric actions on pseudo-Riemannian nilmanifolds","resumen":"This work deals with the structure of the isometry group of pseudo-Riemannian 2-step nilmanifolds. We study the action by isometries of severalgroups and we construct examples showing substantial dierences with the Riemanniansituation; for instance the action of the nilradical of the isometry groupdoes not need to be transitive. For a nilpotent Lie group endowed with a leftinvariantpseudo-Riemannian metric we study conditions for which the subgroupof isometries xing the identity element equals the subgroup of isometric automorphisms.This set equality holds for pseudo-H-type Lie groups.","palabras_clave":"pseudo-Riemannian nilmanifolds|nilpotent Lie groups|isometry groups|bi-invariant metrics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37971,"idioma_id":4,"titulo":"In vitro transfection of bone marrow-derived dendritic cells with TATp-liposomes","resumen":"Dendritic cells (DC) are antigen-presenting cells uniquely capable of priming naïve T cells and cross-presenting antigens, and they determine the type of immune response elicited against an antigen. TAT peptide (TATp), is an amphipathic, arginine-rich, cationic peptide that promotes penetration and translocation of various molecules and nanoparticles into cells. TATp-liposomes (TATp-L) used for DC transfection were prepared using TATp derivatized with a lipid-terminated polymer capable of anchoring in the liposomal membrane. Here, we show that the addition of TATp to DNA-loaded liposomes increased the uptake of DNA in DC. DNA-loaded TATp-L increased the in vitro transfection efficiency in DC cultures as evidenced by a higher expression of the enhanced green fluorescent protein and bovine herpes virus type 1 glycoprotein D (gD). The de novo synthesized gD protein was immunologically stimulating when transfections were performed with TATp-L, as indicated by the secretion of interleukin 6. ","palabras_clave":"TAT peptide|bovine herpes virus 1 glycoprotein D|dendritic cell transfection|green fluorescent protein"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37972,"idioma_id":4,"titulo":"Transcriptomic survey of cotton boll weevil Anthonomus grandis midgut","resumen":"Anthonomus grandis Boheman is a key pest in cotton crops in the New World. Its larval stage develops within the flower  bud using it as food and as protection against its predators. This behavior limits the effectiveness of its control using conventional insecticide  applications and biocontrol techniques. In spite of its importance, little is known about its genome sequence and, more important,  its specific expression in key organs like the midgut. Total mRNA isolated from larval midguts was used for pyrosequencing.  Sequence reads were assembled and annotated to generate a unigene data set. In total, 400,000 reads from A. grandis midgut with an  average length of 237 bp were assembled and combined into 20,915 contigs. The assembled reads fell into 6,621 genes models. BlastX  search using the NCBI-NR database showed that 3,006 unigenes had significant matches to known sequences. Gene Ontology (GO)  mapping analysis evidenced that A. grandis is able to transcripts coding for proteins involved in catalytic processing of macromolecules  that allows its adaptation to very different feeding source scenarios. Furthermore, transcripts encoding for proteins involved in detoxification  mechanisms such as p450 genes, glutathione-S-transferase, and carboxylesterases are also expressed. This is the first report of a  transcriptomic study in A. grandis and the largest set of sequence data reported for this species. These data are valuable resources to  expand the knowledge of this insect group and could be used in the design of new control strategies based in molecular information.","palabras_clave":"Picudo |Algodón|transcriptómica|genómica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37973,"idioma_id":4,"titulo":"Facets and valid inequalities for the time-dependent travelling salesman problem","resumen":"The Time-Dependent Travelling Salesman Problem (TDTSP) is a generalization of the traditional TSP where the travel cost between two cities depends on the moment of the day the arc is travelled. In this paper, we focus on the case where the travel time between two cities depends not only on the distance between them, but also on the position of the arc in the tour. We consider two formulations proposed in the literature, we analyze the relationship between them and derive several families of valid inequalities and facets. In addition to their theoretical properties, they prove to be very effective in the context of a Branch and Cut algorithm.","palabras_clave":"TIME DEPENDENT TSP|INTEGER PROGRAMMING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37974,"idioma_id":4,"titulo":"Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expression","resumen":"The term molecular chaperone was first used to describe the ability of  nucleoplasmin to prevent the aggregation of histones with DNA during the  assembly of nucleosomes. Then, the name was also extended to those proteins  that mediate the post-translational assembly of protein complexes protecting  them from denaturation and aggregation. Hsp90 is a chaperone that represents the  major soluble protein of the cell, but its role is to provide biological  activity to properly folded client proteins with a preserved tertiary structure.  Therefore, in contrast to most chaperones, Hsp90 functions as a delicate and  refined sensor of protein function rather than a gross folding factor. Hsp90 is related to basic cell functions such as cytoplasmic  transport of soluble factors, translocation of client proteins to organelles,  and the regulation of the biological activity of a number of key signalling  factors and other proteins such as protein kinases, steroid receptors, cell  cycle regulators, transcription factors, etc. Growing number of  evidences link the protective action of this chaperone to mechanisms related to  posttranslational modifications of key soluble nuclear factors as well as  histones. In this article, we discuss some aspects of the regulatory action of  Hsp90 on transcriptional regulation and how this could have impacted the  genetic assimilation of organisms.","palabras_clave":"Hsp90|HDAC6|Tah1-Pih1|SmyD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37975,"idioma_id":4,"titulo":"Study of the influence of ascorbyl palmitate and amiodarone in the stability of unilamellar liposomes","resumen":"Abstract        Amiodarone (AMI) is a low water-solubility drug,  which is very useful in treatment of severe cardiac disease. Its adverse effects are  associated with toxicity in different tissues. Several antioxidants have been shown to reduce, and  prevent AMI toxicity. The aim of this work is to develop and characterize  Dimyristoylphosphatidylcholine (DMPC) liposomal carriers doped with ascorbyl palmitate (Asc16) as  antioxidant, in order to either minimize or avoid the adverse effects produced by AMI. The  employment of liposomes would avoid the use of cosolvents in AMI formulations, and Asc16 could  minimize the adverse effects of AMI. To evaluate the partition and integration of AMI  and Asc16 in lipid membranes, penetration studies onto DMPC monolayers were carried out.  The disturbance of the liposomes membranes was studied by generalized  polarization (GP). The stability of liposomes was evaluated experimentally and by mean of the  Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. The size particle and zeta potential (æ) values of the liposomes were used to be applied in calculations for attractive and  repulsive forces inDLVO theory.In experimental conditions all of these vesicles shown stability  at time 0, but only DMPC+Asc16 10% + AMI 10% liposomes kept stable their size and æ during 28 days. These results are encouraging and suggest that such systems could be suitable  for AMI delivery formulations.        ","palabras_clave":"AMIODARONE|ASCORBYL PALMITATE|LIPOSOMES|STABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37977,"idioma_id":4,"titulo":"Water stress response of Tricepiro and its progenitors Triticale and Trigopiro","resumen":"In semiarid regions rainfall is often scarce and erraticin space and time, making valuable the exploration of news genotypeswith superior behavior in dry land systems. Tricepiro (X TriticosecaleWittmack x X Agrotriticum Ciferri &amp; Giacom) is a syntheticcereal with long cycle and high biomass production in semiarid environments.However its performance under controlled water stresshas not yet been evaluated. The aim of this work was to investigatethe effect of water stress on tricepiro genotypes in comparison withtheir progenitors: triticale and trigopiro. Morphophysiological traitsrelated to forage yield were evaluated in the greenhouse and the field.In the greenhouse, water potential, stomatal resistance, root biomassand wilted\/green leaves were significantly associated with forageproduction under severe water stress [leaf water potential (WP) =-3 MPa]. In the field, under mild-moderate stress (leaf WP = -1.23MPa), forage yield was highly related to plant height and leaf areaindex. We found that under water stress tricepiro performed similarto triticale, and both were superior to trigopiro. Among tricepiros,L62 and the line RC50 were the best performing genotypes. Hence,tricepiro has potential to diversify cropping systems in Semiarid Regions.","palabras_clave":"Tricepiro|Synthetic cereal|Drught|Semiarid environment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37978,"idioma_id":4,"titulo":"Physical and functional properties of blackberry freeze and spray dried powders","resumen":"The aim of the present work was to develop two products from blackberry juice by freeze- and spray-drying with the potential use as food colorants or healthy ingredients. A characterization of the physical and functional properties of the powdered juices was done. Maltodextrin or a mixture of trehalose and maltodextrin were assessed as carrier matrices. Freeze-dried maltodextrin-containing powders presented the best retention of bioactive compounds and antiradical activity; however, it showed a narrow relative humidity range for storage in glassy state. Spray-dried powders showed better physical properties, bearing higher glass transition temperature values and lower molecular mobility than freeze-dried formulations.","palabras_clave":"FREZZE DRIED|BLACKBERRY|SPRAY DRIED"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37979,"idioma_id":5,"titulo":"EL ESTORNINO PINTO (Sturnus vulgaris) EN GENERAL LAVALLE, BUENOS AIRES, ARGENTINA","resumen":"En Argentina, el Estornino Pinto (Sturnus vulgaris)  es una especie exótica cuyo primer registro es de 1987. Es considerada una especie invasiva por su gran capacidad de adaptarse y reproducirse en zonas  urbanas y periurbanas formando bandadas de miles de individuos. En noviembre de 2013 se observaron seis individuos de Estornino Pinto en un bosque con eucaliptos (Eucalyptus sp.), álamos (Populus sp.), tala (Celtis ehrenbergiana), y coronillo (Scutia buxifolia), a 280 m del casco de la estancia La Esperanza, partido de General Lavalle, provincia de Buenos Aires (36°28?S, 56°58?O). Estos ejemplares se  desplazaban entre eucaliptos y álamos mientras emitían llamadas de alarma. También se observaron interacciones agresivas entre una pareja nidificante de Carpinteros  Campestres (Colaptes campestris)","palabras_clave":"estornino pinto|especie invasiva|General Lavalle"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37980,"idioma_id":4,"titulo":"Characterization of Converter Refractories for Recycling","resumen":"The lining of steel converters and ladles consists of magnesia-graphite refractories. The steel industry is the biggest consumer of refractories, about 70% of the total production of these materials. For this reason, it is very important to recycle them for the production process. The aim of this work is to carry out the physicochemical and microstructural characterization of post-mortem magnesia-graphite refractories from a steel plant, in order to achieve their incorporation to the manufacture of ceramic masonry to be used in the construction industry. The obtained results indicate acceptable properties in these industrial wastes in relation to the physicochemical and environmental characteristics and the feasibility of reusing them in the mentioned applications.","palabras_clave":"RECYCLING|STELL INDUSTRIES|REFRACTORIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37981,"idioma_id":4,"titulo":"BOTTOM ASH FROM MINERAL COAL AS AGGREGATE IN MIXTURES FOR CERAMIC PRODUCTS","resumen":"The objective of this work is to analyze ashes from a thermal power plant with the aim of determining its environmental aptitude for reutilization as aggregates in clay mixtures for ceramics production. To achieve this objective the waste material was characterized by different techniques: optical microscopy, scanning electronic microscopy, conductivity, pH, among others. Clay samples with bottom ash addition, up to 50%, were prepared. These samples were thermally treated at 950°C and then characterized with diverse techniques in order to determine their behaviour in service. The obtained results show the high feasibility of reutilization of the studied waste as raw material in the production of ceramic products.","palabras_clave":"WASTES|ASHES|CERAMICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37982,"idioma_id":4,"titulo":"Nanocomposites films based on soy proteins and montmorillonite processed by casting","resumen":"In this work we prepared flexible nanocomposite films consisting in a soy-protein (SP) matrix supplemented with different concentrations of montmorillonite (MMT) up to 10 g\/100 g of SP by the tecnique of casting. The resulting films were homogeneous, yellowish, and transparent and indistinguishable visually from films of pure protein. The process used for film formation\u2014involving mechanical agitation and ultrasonication, in combination with the intrinsic affinity of MMT for the SPs\u2014favors the dispersion of the clay so as to reach a high degree of intercalaction into the protein matrix with consequent exfoliation of the layers of MMT among the proteins (verified by both transmission electron microscopy and x-ray diffraction).The efficient dispersion and distribution of the MMT laminas within the films generated a significant strengthening of the nanolayer that was evident in the observed resistance to breakage; modulation of elasticity; and decrease in extension, moisture content, solubility, and permeability to water vapor.\tIn the presence of MMT, the disulfide bridges in the SPs play a critical role in the stabilization of the protein matrix, whereas in the films composed of proteins alone the residues capable of participating in hydrogen bonding would be involved in other types of highly stabilizing interactions.","palabras_clave":"BIONANOCOMPOSITES|SOY PROTEIN|MONTMORILLONITE|BIODEGRADABLE FILMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37983,"idioma_id":4,"titulo":"Double Dissociations in the Processing of Conceptual Relations","resumen":"Conceptual relations are the links that connect concepts with each other. Two types, Taxonomic and thematic,are of particular interest. The language and simulation theory proposed by Barsalou, Santos, Simmons & Wilson (2008) suggests that there are two principal systems involved in conceptual processing: the linguistic system and the simulation system. The aim of the present paper is to analyze if taxonomic and thematic conceptual relations are processed primarily in the linguistic system, in the simulation system or in both. Because the verbal modality is the best way to access the linguistic system and the pictorial modality is the best way to access the simulation system (Barsalou, 1999), we studied these processes through verbal and pictorial tasks. We studied a group of 60 patients with focal brain lesions to explore the presence of double dissociation, based on the assumption that such patients will reveal the existence of independent processes according to conceptual relation type and the modality in which information is presented (verbal vs. pictorial). The results reveal the presence of double dissociations in the processing of thematic relations, but not in taxonomic relations. This suggests that there may be two ways to store relations of this type: through the co-occurrence of words in language or through the joint representation of both objects in a contextual representation. This implies that thematic relations may be primordially stored within one of the two systems (linguistic and simulation) or both. Taxonomic relations, on the other hand, are principally processed in the simulation system.      Manuscript # 19038  Authors:    [ edit authors ]  1. Leticia Vivas    [ Add CV ]  2. Ricardo García-García    [ Add CV ]  3. Jorge Vivas    [ Add CV ]  4. María Victoria Perea-Bartolomé    [ Add CV ]  Short title:    Dissociations in Conceptual Relations  Title and abstract in english language:  Title:Double Dissociations in the Processing of Conceptual Relations","palabras_clave":"TAXONOMIC RELATIONS|THEMATIC RELATIONS|STROKE|CONCEPTUAL KNOWLEDGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37984,"idioma_id":5,"titulo":"Caracterización de soldaduras circunferenciales  de aceros avanzados 9Cr: Parte 1","resumen":"Los aceros 9 % Cr son ampliamente utilizados para servicio a alta temperatura, principalmente en aplicaciones relacionadas a la generación de energía. Últimamente se han desarrollado variantes de estos materiales incorporando B, W y Co, entre otros elementos, al sistema de aleación. Debido a que es escasa la información sobre la influencia del procedimiento de soldadura sobre la junta soldada, en este trabajo se estudió el comportamiento del metal base y el metal de soldadura en juntas circunferenciales soldadas con dos consumibles diferentes por el proceso de soldadura semiautomática bajo protección gaseosa. Se utilizaron dos alambres tubulares de escoria rutílica, aleados al 9Cr1Mo y 9Cr0,5Mo1W respectivamente, bajo protección de Ar\/20%CO2 .Se analizó la microestructura en las zonas: metal de soldadura,  afectada por el calor (zonas de grano grueso, grano fino, intercrítica y subcrítica) y metal base sin afectar. Se determinaron la composición química del metal de soldadura y las propiedades de tracción transversal a la junta  y se realizaron barridos de microdureza. En la próxima etapa se llevarán a cabo las mediciones de la tenacidad y la resistencia al creep.","palabras_clave":"Aceros 9Cr-1Mo|Tratamientos térmicos post soldadura|alambres tubulares"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37985,"idioma_id":4,"titulo":"First description of hemagglutination in Dicistroviridae","resumen":"Triatoma virus is the only virus whose genome  has been sequenced and studied in triatomines. It belongs  to the family Dicistroviridae. In order to detect whether  TrV has the ability to agglutinate erythrocytes of domestic  and laboratory animals, we performed a hemagglutination  assay. Positive hemagglutination was found for red blood  cells of guinea pigs. The HA assay could be used as a  titration method, at least for purified viral particles  obtained from triatomine stool. This is the first record of  hemagglutinating properties for Dicistroviridae.","palabras_clave":"Dicistroviridae|Triatoma virus|Hemaglutination"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37986,"idioma_id":5,"titulo":"GEOHELMINTIASIS EN LA ARGENTINA UNA REVISIÓN SISTEMÁTICA","resumen":"Con el objetivo de analizar la prevalencia y distribución de las geohelmintiasis en la Argentina e identificar las áreas de mayor riesgo, realizamos una revisión sistemática de los estudios poblacionales publicados entre 1980 y 2011, indexados en las bases MEDLINE\/ PUBMED y\/o LILACS. También se incluyeron los datos de prevalencia basal del Programa Nacional de Desparasitación Masiva (PNDM, 2005). Se identificaron 310 publicaciones, de las que solo 24 artículos con información sobre 26 relevamientos, realizados en 8 provincias y un total de 5495 individuos evaluados, cumplían los criterios de inclusión. La prevalencia de geohelmintiasis varió ampliamente: Ascaris lumbricoides 0-67%, uncinarias 0-90%, Trichuris trichiura 0-24.5%, Strongyloides stercoralis 0-83%. La prevalencia acumulada estimada de los 4 geohelmintos principales varió entre 0.8 y 88.6%. Los datos basales del PNDM con información de 1943 niños de 12 provincias confirman esta heterogeneidad con rangos de prevalencia acumulada entre 0 y 42.7%. Los estudios incluidos en esta revisión muestran que la distribución de geohelmintiasis en la Argentina es heterogénea, con focos de alta prevalencia (> 20%) en el noreste y noroeste del país, los que podrían beneficiarse de una estrategia de desparasitación masiva. En muchos casos esta alta prevalencia es debida a uncinarias y estrongiloidiosis, lo que debe tenerse en cuenta para definir las estrategias diagnósticas y terapéuticas para su control. Asimismo, se resalta la escasez o ausencia de datos, con información de menos de la mitad de las provincias y menos de 8000 individuos evaluados.","palabras_clave":"Geohelmintiasis|Argentina|Strongyloides stercoralis|Uncinarias"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37987,"idioma_id":5,"titulo":"Especies de Aspergillus en ambientes hospitalarios con pacientes pediátricos en estado crítico","resumen":"Antecedentes: Aspergillus es un hongo oportunista que provoca infecciones con alta morbimortalidad  en pacientes inmunosuprimidos. Aspergillus fumigatus causa frecuentemente infecciones nosocomiales,  pero la incidencia de otras especies ha aumentado en los últimos a?nos.  Objetivos: Evaluar la carga fúngica aérea y la diversidad de especies de Aspergillus en ambientes hospitalarios  con pacientes pediátricos en estado crítico.  Métodos: Durante oto?no y primavera, cada 15 días, se muestrearon aire y superficies de la Unidad de  Terapia Intensiva y la Unidad de Quemados de un hospital pediátrico. Las muestras de aire se tomaron  con el SAS Super 100®, y las de superficies, con el método del hisopo.  Resultados: Los recuentos de UFC\/m3 superaron los niveles admisibles. En la Unidad de Terapia Intensiva  se encontró mayor cantidad de UFC\/m3 y mayor diversidad de especies de Aspergillus que en la Unidad  de Quemados. La carga fúngica y la diversidad de especies dentro de las salas fueron mayores que en  los ambientes control. La aplicación conjunta del método del hisopo y del SAS permitió encontrar mayor  diversidad de especies. Se aislaron 96 cepas de Aspergillus, de las cuales se identificaron 12 especies.  Destacaron por su alta frecuencia Aspergillus sydowii, Aspergillus niger, Aspergillus flavus, Aspergillus terreus  y Aspergillus parasiticus. Se aisló Aspergillus fumigatus de ambas salas, especie considerada inaceptable en  ambientes internos.  Conclusiones: Aspergillus se aisló con una alta frecuencia en estas salas. Muchas de estas especies son  de interés en salud pública por s","palabras_clave":"Aspergillus|ambiente hospitalario|monitoreo ambiental|vigilancia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37988,"idioma_id":4,"titulo":"Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE","resumen":"Capillary electrophoresis (CE) was used to follow Diclofenac tablet dissolution, in very short times and allowing dissolution testing without volume replacement. By using Student´s t test and F-test, this CE method was compared with HPLC. Statistical data show that there are no significant differences among them. The drug release kinetic of diclofenac tablets was described by various mathematical models and equations. Model-Independent Methods: t50% = 10.34 min; t80% = 20 min; DE% = 79.41% and MDT = 10.85 min, show that diclofenac tablet dissolution rate is very high, having 80% drug dissolution within 20 minutes. Model-Dependent Methods. The kinetics models used were: zero order, first order, Hixson?Crowell cube root law, Higuchi model, and Weibull model. Criteria used to choose the best model was by comparisson of r2 and AIC (Akaike Information Criteria). The model that best adjusts diclofenac tablet dissolution profilewas the Hixson-Crowell cube root model.","palabras_clave":"Capillary electrophoresis |diclofenac|dissolution|Hixson-Crowell"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37989,"idioma_id":4,"titulo":"Prenatal stress changes the glycoprotein GPM6a gene expression and induces epigenetic changes in rat offspring brain","resumen":"Prenatal stress (PS) exerts strong impact on fetal brain development and on adult offspring brain functions. Previous work demonstrated that chronic stress alters the mRNA expression of GPM6A, a neuronal glycoprotein involved in filopodium extension. In this work, we analyzed the effect of PS on gpm6a expression and the epigenetic mechanisms involved. Pregnant Wistar rats received restraint stress during the last week of gestation. Male offspring were sacrificed on postnatal days 28 and 60. Hippocampus and prefrontal cortex samples were analyzed for gene expression (qPCR for mRNAs and microRNAs), methylation status (bisulfite conversion) and protein levels. Hippocampal neurons in culture were used to analyze microRNA overexpression effects. Prenatal stress induced changes in gpm6a levels in both tissues and at both ages analyzed, indicating a persistent effect. Two CpG islands in the gpm6a gene were identified. Variations in the methylation pattern at three specific CpGs were found in hippocampus, but not in PFC samples from PS offspring. microRNAs predicted to target gpm6a were identified in silico. qPCR measurements showed that PS modified the expression of several microRNAs in both tissues, being microRNA-133b the most significantly altered. Further studies overexpressing this microRNA in neuronal cultures showed a reduction in gmp6a mRNA and protein level. Moreover filopodium density was also reduced, suggesting that GPM6A function was affected. Gestational stress affected gpm6a gene expression in offspring likely through changes in methylation status and in posttranscriptional regulation by microRNAs. Thus, our findings propose gpm6a as a novel target for epigenetic regulation during prenatal stress.","palabras_clave":"CpG ISLAND|DNA METHYLATION PATTERN|HIPPOCAMPUS|PREFRONTAL CORTEX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37990,"idioma_id":4,"titulo":"Entropy of a Rindler observer","resumen":"We compute the entropy of a Rindler particle-detector (observer) in the presence of a quantum field in the Minkowski vacuum state; due to the Unruh effect, the observer is immersed in a thermal bath at a temperature proportional to its proper acceleration.","palabras_clave":"RINDLER SPACE|UNRUH EFFECT|ENTROPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37991,"idioma_id":5,"titulo":"Deformacion Sismica Reciente de la Sierra de Pie de Palo, Provincia de San Juan","resumen":"In this paper we study the seismic activity in the Sierra de Pie de Palo during January 2008 to December 2009 using data recorded by 52 seismic stations from the projects SIEMBRA and ESP;  crustal earthquakes were located with local magnitudes between 0.8 <M <3.7 and depths down to 40 km. The results indicate that the seismicity is mainly distributed in the Sierra de Pie de Palo with a gap in the central western of the range and the Tulum Valley. There is a different pattern  for the crust located to the north and that one to the south of the range: in the northern block, 52 hypocenters have occurred at middle to lower crust levels while in the southern block, 73 earthquakes are mainly concentrated at intermediate crustal levels. There is a good correlation within the seismicity with the local crust model proposed by Perarnau et al. (2010), observing most of the seismic activity located at middle-to-lower crust levels. The absence of seismic activity in the lowermost part of crust suggests a more ductile behavior. We could constrain 128 focal mechanisms using P-wave first motions which indicate reverse type solutions mainly and secondly reverse with strike-slip components in the solutions; this agrees well with a crustal shortening in an approximate east-west direction. It is possible to distinguish at least two basement blocks whose movements and associated deformation seems to behave independently one with respect to another, both in areal extension as well as in depth location for the range.","palabras_clave":"Sismos corticales|retroarco andino|nivel de despegue|mecanismos focales|bloques de basamento"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37992,"idioma_id":4,"titulo":"Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis","resumen":"A new ion generation method, named plasma-spray ionization (PLASI) for  direct analysis of liquid streams, such as in continuous infusion experiments or liquid chromatography (LC), is reported. PLASI addresses many of the analytical limitations of electrospray ionization (ESI) and has potential for real time process stream analysis and reaction monitoring under atmospheric conditions in non-ESI friendly scenarios. In PLASI-mass spectrometry (MS), the liquid stream is pneumatically nebulized and partially charged at low voltages; the resultant aerosol is thus entrained with a gaseous plasma plume from a distal glow discharge prior to MS detection. PLASI-MS not only overcomes ESI-MS limitations but also generates simpler mass spectra with minimal adduct and cluster formation. PLASI utilizes the atomization capabilities of an ESI sprayer operated below the ESI threshold to generate gas-phase aerosols that  are then ionized by the plasma stream. When operated at or above the ESI threshold, ionization by traditional ESI mechanisms is achieved. The multimodal nature of the technique enables readily switching between plasma and ESI operation. It is expected that PLASI will enable analyzing a wide range of analytes in complex matrices and less-restricted solvent systems, providing more flexibility than that achievable by ESI alone.","palabras_clave":"DART|MASS SPECTROMETRY|PLASMA IONIZATION|PROCESS AND REACTION MONITORING|LIQUID-PHASE SEPARATIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37993,"idioma_id":4,"titulo":"SURFACE AND HYSTERESIS PROPERTIES OF LIPID INTERPHASES  COMPOSED BY HEAD GROUP SUBSTITUTED PHOSPHATIDYLETHANOLAMINES","resumen":"This work analyzes the surface properties of PE-containing membranes modified at the head group region by the addition of methyl and ethyl residues at or near the amine group. These residues alter the lipid?lipid and lipid?water interactions by changes in the hydrogen bonding capability and the charge density of the amine group thus affecting the electrostatic interaction.  The results obtained by measuring the dipole potential, the zeta potential, the area per lipid and the compressibility properties allow to conclude that the H-bonding capability prevails in the lipid-lipid interaction. The non polar groups attached to the C2-carbon of the ethanolamine chain introduces a steric hindrance against compression and increases the dipole potential. The analysis of areas suggests that lipids with methylated head groups have a much larger compressibility at expense of the elimination of hydration water, which is congruent with the broader extent of the hysteresis loop.","palabras_clave":"LIPID|WATER|HYDROGEN BONDING|HYSTERESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37994,"idioma_id":4,"titulo":"Cyclic AMP efflux through MPRs is critical in the regulation of bovine sperm capacitation: \tcontribution of A1 adenosine receptors","resumen":"Sperm capacitation has been largely associated with an increase in cAMP, although its relevance in the Underlying mechanisms of this maturation process remains elusive. Increasing evidence shows that the extrusion of cAMP through multidrug resistance associated protein 4 (MRP4), regulates cell homeostasis not only in physiological but also in pathophysiological situations and studies from our laboratory strongly support this assumption. In the present work we sought to establish the role of cAMP efflux in the regulation of sperm capacitation. Sperm capacitation was performed in vitro by exposing bovine spermatozoa to bicarbonate 40 and 70 mM; cAMP; probenecid (a MRPs general inhibitor) and an adenosine type 1 receptor (A1 adenosine receptor) selective antagonist (DPCPX). Capacitation was assessed by chlortetracycline assay and lysophosphatidylcholine-induced acrosome reaction assessed by PSA-FITC staining. Intracellular and extracellular cAMP was measured by a  59 radio binding assay to the regulatory subunit of PKA under the same experimental conditions. MRP4 was detected by Western blot and immunohistochemistry assays. Results showed that the inhibition of  soluble adenylyl cyclase significantly inhibited bicarbonate-induced sperm capacitation. Furthermore,in the presence of 40 and 70 mM bicarbonate bovine spermatozoa synthesized and extruded cAMP.  Interestingly, in the absence of IBMX (a PDEs inhibitor) cAMP efflux still operated in sperm cells,suggesting that cAMP extrusion would be a physiological process in the spermatozoa complementary to the action of PDE. Blockade of MRPs by probenecid abolished the efflux of the cyclic nucleotide resulting not only in the accumulation of intracellular cAMP but also in the inhibition of bicarbonate induced sperm capacitation. The effect of probenecid was abolished by exposing sperm cells to cAMP.  The high affinity efflux pump for cAMP, MRP4 was expressed in bovine spermatozoa and localized to the mid-piece of the tail as previously reported for soluble adenylyl cyclase and A1 adenosine receptor.  Additionally, blockade of A1 adenosine receptor abolished not only bicarbonate-induced sperm capacitation but also that stimulated by cAMP. Present findings strongly support that cAMP efflux, presumably through MRP4, and the activation of A1 adenosine receptor regulate some events associated to bicarbonate-induced sperm capacitation, and further suggest a paracrine and\/or autocrine role for cAMP.","palabras_clave":"cAMP EFFLUX|MRP4|SPERM CAPACITATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37995,"idioma_id":4,"titulo":"Synthesis of Fe\/SiO2 and iron oxides\/SiO2 nanocomposites by long-term ball milling","resumen":"Iron oxide\/SiO2 nanocomposites are synthesized by dry ball-milling a mixture of bcc Fe and a-quartz  powders for prolonged times. A sequence of nanocomposites is obtained, with small magnetic particles  dispersed in a non magnetic, amorphous matrix. The powders are characterized by X-ray diffraction and  transmission electron microscopy. The magnetic hysteresis properties are investigated in the range 50?  300 K. After 120 h milling, deformed, non-spherical, a-Fe nanocrystallites of about 10 nm in size and  very few small (<10 nm) maghemite particles are found. At room temperature, iron particles are  ferromagnetic and a large effective magnetic anisotropy is estimated, which is mainly attributed to  surface effects. Between 160 and 200 h milling, maghemite nanoparticles are observed while after 220 h  grinding, hematite phase appears; after 340 h milling, the sample consists of ferromagnetic hematite  particles with a broad size distribution (5?50 nm) embedded in an amorphous matrix.","palabras_clave":"particulate composites|iron oxides|dry ball milling|magnetic properties"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37996,"idioma_id":4,"titulo":"Role of Plasma Membrane Lipid Composition on Cellular Homeostasis:  Learning from Cell Line Models over Expressing Fatty Acid Desaturases","resumen":"Experimental evidence suggests that plasma membrane (PM) -associated signaling and hence cell metabolism and viability depend on lipid composition and organization. The aim of this work is to develop a cell model to study the endogenous polyunsaturated fatty acids (PUFA) effect on PM properties and analyze its influence on cholesterol (Chol) homeostasis. We have previously shown, using a cell line over-expressing Stearoyl-CoA-Desaturase (SCD), that membrane composition and organization coordinate cellular pathways involved in Chol efflux and cell viability by different mechanisms. Now we expand our studies to a cell model over-expressing both &#916;5 and &#916;6 desaturases, which results in a permanently higher PUFA content in PM. Furthermore, this cell line showed increased PM fluidity, Chol storage and mitochondrial activity. In addition, human apolipoprotein A-I (apoA-I)-mediated Chol removal was less efficient in these cells than in the corresponding control. Altogether, our results suggest that cell functionality is preserved by regulating plasma membrane organization and Chol exportation and homeostasis.","palabras_clave":"Fatty acid desaturases|apolipoprotein A-I|Plasma Membrane Organization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37997,"idioma_id":4,"titulo":"Redescription of the skull of Coloradisaurus brevis (Dinosauria, Sauropodomorpha) from the Late Triassic Los Colorados Formation of the Ischigualasto-Villa Union Basin, Northwestern Argentina","resumen":"The cranial anatomy of the basal sauropodomorph Coloradisaurus brevis from the upper levels of the Norian Los Colorados Formation is here redescribed and comparisons made based on the holotype skull and mandible. Coloradisaurus brevis is diagnosed by most of the features proposed in the original description and an additional set of autapomorphies, such as presence of circular upper temporal fenestrae, laminae on the ventrolateral margins of a ventral fossa of the basisphenoid and on the ventral region of the parasphenoid, and tab-like medial process at the posteromedial end of the mandible. Coloradisaurus is placed within Massospondylidae, as in recent analyses. This position is supported primarily by postcranial characters, but some cranial features identified in this study provide additional evidence supporting this position (e.g., jugal contribution to the antorbital fenestra, frontal proportionately longer than nasals). However, the cranial anatomy of Coloradisaurus also bears several characters that are shared with plateosaurids (e.g., low mandibular articulation, broad maxillary wall on the anterior margin of antorbital fossa, broad prefrontals, projection of infratemporal fenestra behind the orbit, stepped braincase, robust septum between basipterygoid processes). Thus, Coloradisaurus is interpreted as a massospondylid that has convergently acquired characters that are otherwise only known in plateosaurids, highlighting the conflicting pattern of character distribution among basal sauropodomorphs.","palabras_clave":"Triassic|Sauropodomorpha|Anatomy|skull"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37998,"idioma_id":4,"titulo":"EXPRESSION OF LYN AND PTEN GENES IN CHRONIC MYELOID LEUKEMIA AND THEIR  IMPORTANCE IN THERAPEUTIC STRATEGY","resumen":"Tyrosine kinase inhibitors (TKIs), imatinib, nilotinib and dasatinib, are the current treatment of chronic myeloid leukemia (CML). BCR-ABL1 point mutations are the principal cause of resistance to treatment; however other mechanisms could be involved in failure to TKI therapy. LYN is a src kinase protein that regulates survival and responsiveness of tumor cells by a BCR-ABL1 independent mechanism. PTEN tumor suppressor gene is downregulated by BCR-ABL1 in CML stem cells and its deletion is associated with acceleration of disease. In this study we evaluated the expression of LYN, PTEN and the ratio of both genes in 40 healthy donors (HD) and in 139 CML patients; 88 of them resistant to TKI in different phases of disease and 51 in chronic phase classified as optimal responders (OR) to TKI [40 treated with imatinib or nilotinib (OR-IN) and 11 treated with dasatinib (OR-D) therapy]. When we analyzed the gene expression values of LYN, an increase was observed only in advanced stages of the disease, however, when we analyzed the ratio between LYN and PTEN genes, the group of resistant patients in chronic phase in imatinib or nilotinib treatment (CP-IN) also showed a significant increase. Resistant patients treated with dasatinib, a src kinase inhibitor, presented a similar ratio to the observed in HD. In addition, the LYN\/PTEN ratio and the LYN expression showed a direct significant correlation with BCR-ABL1 transcript levels in unmutated resistant patients treated with non-src kinase inhibitors. We were able to identify 8\/35 (23%) of cases in CP-IN and 4\/12 (33%) in accelerated phase and blast phase (AP\/BC-IN), in which resistance could be associated with an increase in the ratio of the LYN\/PTEN. Our data suggest that the LYN\/PTEN expression ratio may be a sensitive monitor of disease progression in unmutated CML patients under imatinib or nilotinib treatment. This ratio could detect cases when resistance is related to altered LYN expression, suggesting that the treatment change to a src kinase inhibitor would be most suitable to overcome resistance.","palabras_clave":"Leukemia|Resistance|Inhibitors"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":37999,"idioma_id":4,"titulo":"Soil fungi: their potential use as a forensic tool","resumen":"Since a grave is an anomalous environment and differs from its surroundings, criminal investigators employ different techniques for locating, recovering, and analyzing clandestine graves. We identified the fungi found in the soil under corpses in decomposition with an aim at relating the copresence of human remains and different fungal species. We isolated the fungi in three ways: soil washing, serial dilutions, and moist-chamber growth. Dichotomomyces cejpii, Talaromyces trachyspermus, Talaromyces flavus, and Talaromyces sp. were the representative species found?with those belonging to the ammonia group, whose fungi are the first in the succession of cadaver decomposition directly in the ground. The mycobiota found at the present study area clearly differs to mycobiota identified in control sample and from previously described species for other areas of Buenos Aires province, Argentine. Further forensic examples of this type are needed to develop fully the detailed use of mycology as a forensic tool.","palabras_clave":"FORENSIC SCIENCES|FORENSIC MYCOLOGY|FORENSIC ASCOMYCOTA|SOIL FUNGI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38000,"idioma_id":4,"titulo":"Move to Usability SOA Arquitecture: Undo Process Implementation","resumen":"    This work  is a new stage of an investigation in usability field, Software as a Service  (SaaS) and Service Oriented Architectures (SOA) conducted by this research  team, which has served to show that in certain types of systems, the  implementation of SaaS model for SOA in usability domain is the appropriate  equation to balance development time, cost and functionality.   ","palabras_clave":"Software as a Service|Service Oriented Architectures"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38001,"idioma_id":4,"titulo":"Ionization of water molecules by ion beams. On the relevance of dynamic screening and the influence of the description of the initial state","resumen":"Single ionization from water molecules by impact of protons, alpha particles and C6 + ions is studied. The post- and prior-versions of the continuum distorted wave-eikonal initial state (CDW-EIS) model within an independent electron approximation are employed to compute double differential cross sections. To avoid the complexity of using numerical molecular continuum states in the cross-section calculations, effective Coulombic continuum wavefunctions are employed. However, this may lead to the appearance of post?prior discrepancies and this fact is examined in detail. Moreover, the influence of the dynamic screening on this behaviour is studied. In addition, the contribution of different molecular orbitals to the angular spectrum is analysed for several ejection electron energies. Finally, the sensitivity of CDW-EIS calculations to the representation of the initial bound molecular orbitals is investigated.","palabras_clave":"IONIZATION|WATER|MOLECULES|DYNAMIC-SCREENING|POST-PRIOR|DISCREPANCIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38002,"idioma_id":4,"titulo":"Effect of prolonged electrode potential cycling on the conduction properties of poly(o-aminophenol) film electrodes","resumen":"The aim of this work was to study the effect of prolonged potentiodynamic cycling (PPC) on the conducting properties of poly(oaminophenol)(POAP) film electrodes. PPC reduces strongly the electron transport rate at POAP films. This effect is called hereindeactivation. Cyclic Voltammetry (CV), Rotating Disc Electrode Voltammetry (RDEV) and Electrochemical Impedance Spectroscopy(EIS) were employed in this study. The attenuation of the voltammetric response of the polymer with the increase in the number ofoxidation-reduction cycles allowed one to define a degree of deactivation. RDEV and EIS were employed to obtain the dependenceof some charge-transport parameters on the degree of deactivation of the polymer. RDEV data were interpreted in terms of theelectron hopping model. Impedance spectra were analysed on the basis of a model which considers a protonation reaction coupledwith a self-exchange process between oxidized and reduced sites. POAP films maintain their conducting properties almost unalteredfor about 500 potential cycles at a scan rate of 0.010 Vs&#1048576;1. However, a loss of conductivity was observed as the number of potentialcycles was extended beyond 500.","palabras_clave":"Poly(o-aminophenol) Film Electrodes|Prolonged Potential Cycling (PPC)|Deactivation|Electron-transport rate"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38003,"idioma_id":4,"titulo":"Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates","resumen":"Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical peptidesexhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).","palabras_clave":"PEPTIDES|CATIONIC|ANTIMICROBIAL|RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38004,"idioma_id":4,"titulo":"Characterization of bacterial diversity associated with microbial mats, gypsum evaporites and carbonate microbialites in thalassic wetlands: Tebenquiche and La Brava, Salar de Atacama, Chile","resumen":"In this paper, we report the presence of sedimentary microbial   ecosystems in wetlands of&nbsp;the Salar de Atacama. These laminated systems,   which bind, trap and precipitate mineral include: microbial mats at   Laguna Tebenquiche and Laguna La Brava, gypsum domes at Tebenquiche and   carbonate microbialites at La Brava. Microbial diversity and key   biogeochemical characteristics of both lakes (La Brava and Tebenquiche)   and their various microbial ecosystems (non-lithifying mats, flat and   domal microbialites) were determined. The composition and abundance of   minerals ranged from trapped and bound halite in organic-rich   non-lithifying mats to aragonite-dominated lithified flat microbialites   and gypsum in lithified domal structures. Pyrosequencing of the V4   region of the 16s rDNA gene showed that Proteobacteria comprised a major   phylum in all of the microbial ecosystems studied, with a marked lower   abundance in the non-lithifying mats. A higher proportion of   Bacteroidetes was present in Tebenquiche sediments compared to La Brava   samples. The concentration of pigments, particularly that of Chlorophyll   a, was higher in the Tebenquiche than in   La Brava. Pigments typically associated with anoxygenic phototrophic   bacteria were present in lower amounts. Organic-rich, non-lithifying   microbial mats frequently formed snake-like, bulbous structures due to   gas accumulation underneath the mat. We hypothesize that the lithified   microbialites might have developed from these snake-like microbial mats   following mineral precipitation in the surface layer, producing domes   with endoevaporitic communities in Tebenquiche and carbonate platforms   in La Brava. Whereas the potential role of microbes in carbonate   platforms is well established, the contribution of endoevaporitic   microbes to formation of gypsum domes needs further investigation.","palabras_clave":"Hypersaline lakes|Microbial mats|Microbialites|Atacama"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38005,"idioma_id":4,"titulo":"Presence of pesticides in surface water from four sub-basins in Argentina","resumen":"Argentina has 31 million hectares given over to agriculture comprising 2.2% of the world?s total area under cultivation (Stock Exchange of Rosario, Argentina). Despite the intensity of this agricultural activity, data on pesticide pollution in surface water are rather scarce. In this sense, the aim of this work is to determine the presence of pesticides in surface water of four agricultural sub-basins of Argentine. An environmental monitoring was carried out to determine the impact of twenty-nine pesticides used in agricultural activities on the surface water quality of agricultural areas within the San Vicente, Azul, Buenos Aires southeast and Mista stream sub-basins.The samples were analyzed by solid-phase extraction (SPE) using OASIS HLB 60&nbsp;mg cartridges and ultra-high-pressure liquid chromatography coupled to tandem mass spectrometry (UHPLC\/MSMS) that provided good analytical quality parameters.The southeast of Buenos Aires was the site with the highest frequency of pesticides detection, followed by Azul and San Vicente microbasins. The most detected pesticides, considering all surface water samples, were atrazine, tebuconazole and diethyltoluamide with maximum concentration levels of 1.4, 0.035, and 0.701&nbsp;&#956;g&nbsp;L&#8722;1, respectively. The results obtained for all basins studied show the presence of residual pesticides in surface waters according the different agricultural activities developed.","palabras_clave":"Pesticides|Surface water|Monitoring|Ultra-performance Chromatography"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38006,"idioma_id":5,"titulo":"Características de la canal y efecto de la maduración sobre la calidad de la carne de ovejas de desvieje de raza Corriedale","resumen":"El objetivo del presente trabajo fue caracterizar la canal de ovejas de desvieje de raza Corriedale y evaluar el efecto del tiempo de maduración sobre la calidad instrumental de la carne. Se utilizaron 10 ovejas adultas con una condición corporal entre 2,5 y 3. En la canal se determinaron el peso de la canal calientey fría, el color del músculo Rectus abdominis, la consistencia y el color de la grasa subcutánea, la conformación, el engrasamiento, la cantidad de grasa pélvicorrenal y las medidas morfométricas. Se calcularon los índices de compacidad y se realizó el despiece de la canal. El estudio de maduración de lacarne (Longissimus dorsi) se realizó en cuatro tiempos (1, 3, 7 y 14 días postmortem). En cada tiempo se realizaron determinaciones de color, pH, pérdidas por cocción y textura. El peso de la canal caliente y fría fue 22,3 kg y 21,8 kg respectivamente, con una conformación O y P (según la escala SEUROP), unengrasamiento 3 y 4 (escala 1 a 5) y una cantidad de grasa pélvicorrenal 2 y 3 (escala 1 a 3). El tiempo de maduración de la carne produjo una disminución en su dureza, cuyos valores fueron 53,0 N y 27,5 N, al día 1 y 14 respectivamente. La gran variabilidad en la dureza de la carne de los diferentes animales en el día 1 fue disminuyendo durante la maduración. En definitiva, se recomendaría un período de 7 días de maduración para lograr una dureza adecuada en la carne de ovejas de desvieje.","palabras_clave":"CONFORMACIÓN|ENGRASAMIENTO|MADURACIÓN|TEXTURA|COLOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38007,"idioma_id":4,"titulo":"Occupancy of 4d states in T (T: Mo, Nb) from   NEXAFS L3,2 spectra of Nd-Fe-B-T alloys","resumen":"Samples of NdyFe(86?y?x)B14Tx (T: Mo, Nb; x = 2, 4; y = 7, 8) alloys were studied by X-ray absorption spectroscopy. The NEXAFS spectra of NdFeB ribbons produced by the melt spinning technique (as quenched, AQ) and subsequently annealed (TT) were taken at Mo and Nb L3,2-edge. We calculated the variations in occupancy ofthe 4d-states (in both additives), finding an opposite trend in their filling. The most significant changes were observed in the T2Nd7 system, for which the electron occupancy in the 4d levels was modified to an excess of 1 electron\/atom (after thermal treatment). The correlation between these results and magnetic features of the alloys are evidenced.","palabras_clave":"NdFeB-based magnets|Additive|Electron occupancy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38008,"idioma_id":4,"titulo":"Experimental design and multiple response optimization. Using the  desirability function in analytical methods development","resumen":"A review about the application of response surface methodology (RSM) when several responses have to be simultaneously optimized in the field of analytical methods development is presented. Several critical issues like response transformation, multiple response optimization and modeling with least squares and artificial neural networks are discussed. Most recent analytical applications are presented in the context of analytical methods development, especially in multiple response optimization procedures using  the desirability function.","palabras_clave":"Experimental design |Response transformation| Multiple response optimization |Desirability function"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38009,"idioma_id":5,"titulo":"Patrones de variación de la densidad de la madera y morfometría celular de Salix babylonica para la determinación de la edad de transición entre madera juvenil y madura","resumen":"El objetivo  del trabajo fue analizar los patrones de variación axial y radial de la  densidad y morfometría celular de la madera de sauce americano y determinar la  edad de transición de madera juvenil a madura. Se muestrearon cinco árboles de  45 años de Salix babylonica var sacramenta de Entre Ríos, Argentina. Se tomaron  muestras a tres alturas en el fuste y en 9 posiciones radiales y se determinó  la densidad básica y la morfometría de fibras y vasos. Los patrones de  variación radial evidenciaron un leve aumento de magnitud con la edad, mientras  que la mayor variación axial se manifestó mayoritariamente entre la base y la  altura de 1,3m el fuste, presentándose diferentes tendencias de acuerdo a la  variable. Dependiendo de la variable analizada, la edad de transición entre  madera juvenil y madura fue de 5 a 10 años o de 10 a 15 años. La longitud y  ancho de fibras y el diámetro de vasos fueron los primeros parámetros en madurar.  Los valores promedio de las variables de la madera juvenil y madura no  mostraron diferencias importantes entre los leños, por lo tanto podrían  considerarse como homogéneos desde el punto de vista anatómico y de densidad.","palabras_clave":"VARIACION RADIAL|REGRESIONES SEGMENTADAS|MORFOMETRIA FIBRAS|MADERA JUVENIL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38010,"idioma_id":4,"titulo":"Contextualization of Holocene beach ridge systems for relative sea-level reconstruction using the SRTM elevation model.","resumen":"Beach ridge plains are a common feature of prograding coastlines and they have in the past been widely used asgeomorphological archives for the reconstruction of past coastal dynamics, event chronologies or late quaternarysea-level change. The most critical parameters for sea-level related research are the consistent de&#64257;nition and con-&#64257;dence of information on surface elevation of the beach ridge deposits.","palabras_clave":"Holoceno|SRTM|DTM|Sea-Level"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38011,"idioma_id":4,"titulo":"Ecosystem engineering by an invasive species, the beaver, increases landscape-level ecosystem function but does not affect biodiversity in Tierra del Fuego?s freshwater systems","resumen":"Aim Ecological theory predicts that invasive ecosystem engineers like the American  beaver (Castor canadensis) in Tierra del Fuego (TDF) affect landscape-level  biodiversity and ecosystem function (BEF) when engineered habitats are novel  or extensive. We tested these hypotheses on freshwater BEF, sampling benthic  habitat and macroinvertebrates in natural lotic (forest and grassland streams)  and natural lentic habitats (bogs, lakes) and beaver-modified lentic ecosystems  (active and abandoned ponds).  Location Tierra del Fuego Archipelago (Chile and Argentina).  Methods To determine effects on patch-scale BEF, we assessed two drivers:  substrate diversity (H&#8242;) and benthic organic matter standing crop (BOM,  g m  2). Extent of impact was estimated as relative stream length (%) for each  patch type in four 1000 ha images.  Results The freshwater landscape was 56% free-flowing streams (natural lotic),  13% bogs and lakes (natural lentic) and 31% active and abandoned beaver  ponds (beaver lentic). While engineering significantly modified lotic habitats  (converting them to ponds), the beaver ponds were largely similar to natural  lentic systems, but engineered lentic patches retained more BOM. While  benthic biodiversity in beaver ponds was less than streams, the assemblage  contained no habitat-specific taxa and was a subset of the natural lentic  community.  Main conclusions Invasive beavers engineer habitats whose biodiversity is similar  to the landscape?s natural lentic habitats, but by increasing the surface area  and unit area retention of BOM via its impoundments, this invasion augments  carbon standing stock approximately 72% in watersheds. While this invasion is  considered the largest alteration to TDF?s forested biome in the Holocene, here  we discover that its impact is to ecosystem function, rather than biodiversity in  the aquatic landscape.","palabras_clave":"diversidad|insectos|castor|Tierra del Fuego"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38012,"idioma_id":5,"titulo":"Un análisis comparado sobre la implementación de políticas de regularización de asentamientos informales en Argentina, Brasil y México","resumen":"En este trabajo se abordan las políticas públicas de regularización dominial y urbanística implementadas en América Latina en las últimas décadas, haciendo hincapié en la experiencia comparativa de tres países de la región: Argentina, Brasil y México. Para ello, se hace una breve reseña del desarrollo del hábitat informal y de la situación habitacional de los países seleccionados. Posteriormente, se analizan la normativa urbana vigente, las políticas de regularización dominial y urbanística implementadas a nivel federal y los diferentes organismos involucrados. Finalmente, se contraponen los diferentes modelos de gestión y articulación interjurisdiccional existentes en cada uno de los países. El análisis se vale de estadísticas oficiales y datos secundarios sobre condiciones habitacionales, normativas urbanas y programas vigentes. Pese a compartir la organización política federal, el análisis comparativo muestra grandes diferencias entre los países en función de los arreglos institucionalesy la relación con el tipo de régimen de propiedad vigente.","palabras_clave":"HABITAT|ORDENAMIENTO URBANO|POLÍTICAS DE REGULARIZACIÒN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38013,"idioma_id":4,"titulo":"A MANUFACTURING PROCESS FOR SHAFT AND PIPE COUPLINGS OF Fe-Mn-Si-Ni-Cr","resumen":"It has been shown that rolling an Fe?15Mn?5Si?9Cr?5Ni (wt.%) alloy at 800 _C followed by annealing at 650 ºC gives a structure ? a high density of stacking faults and enough austenite hardness ? that promotes the stress induced martensitic transformation instead of plastic deformation. After this thermo-mechanical processing, the material recovers around 95% of a 3% permanent deformation excursion. This work addresses the formability and weldability of sheets processed in that manner and how welding affects the mechanical and shape memory properties. Here, the designs and verification are presented for a new method for manufacturing couplings by forming and welding, and finally, the degree of shape recovery in couplings manufactured by this new method are evaluated. The results show that these couplings recover 83% of their diametrical expansion, which make them suitable for many industrial applications.","palabras_clave":"Shape-memory|Fe-Mn-Si|Welding|Manufacturing couplings"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38014,"idioma_id":4,"titulo":"Sedimentology and sequence stratigraphy of a Tithonian - Valanginian carbonate ramp (Vaca Muerta Formation): A misunderstood exceptional source rock in the Southern Mendoza area of the Neuquén Basin, Argentina","resumen":"The Vaca Muerta Formation (early Tithonian?early Valanginian) is a rhythmic succession of marls and limestones,cropping out in the Neuquén Basin, west-central Argentina. This lithostratigraphic unit was traditionally interpreted as basinal to slope deposits. Detailed facies analysis allows to differentiate seven facies associations,representing basinal to middle ramp facies of a homoclinal ramp system prograding westward from the Eastern margin, and slope facies attributed to a distally steepened ramp systemthat progrades eastward fromthe Andeanvolcanic arc in the west. Two sequence hierarchies are recognized: five third order depositional sequences, and fifteen fourth order high-frequency sequences. Fluctuations in organic matter content within the Vaca Muerta Formation suggest relationship with depositional sequences, finding the highest values associated with transgressive systemtracts. This work represents an important advance in the understanding of the sedimentary and stratigraphic evolution of this exceptional unconventional reservoir. Our sequence stratigraphic approachcontributes to the understanding of the relationship between organic matter, facies, and sea-level changes.","palabras_clave":"CARBONATE RAMPA|SOURCE ROCK|SHALE-GAS SYSTEMS|DEPOSITIONAL SEQUENCES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38015,"idioma_id":4,"titulo":"Early Cretaceous crustacean microcoprolites from Sierra de la Cara Cura, Neuquén Basin, Argentina: Taphonomy, environmental distribution, and stratigraphic correlation","resumen":"new Early Cretaceous association of crustacean microcoprolites from the southern Mendoza sector of the Neuquén Basin, includes Palaxius salataensis Brönnimann, Cros and Zaninetti, 1972; Palaxius caucaensis Blau, Moreno and Senff, 1995; and Favreina cf. F. belandoi Fels, 1997. This microcoprolite association occurs in the Vaca Muerta and Chachao Formations (upper Berriasianelower Valanginian), but Palaxius caucaensis is the first record of crustacean microcoprolites in the Mulichinco Formation and its first occurrence in Lower Cretaceous deposits. Preservation of these microcoprolites is probably a consequence of the low mud-availability in the environment together with a reduced compaction and neomorphism during diagenesis. Crustacean microcoprolites occur in outer to middle ramp deposits, suggesting that they were transported as sand-size particles.","palabras_clave":"PALAXIUS|FAVREINA|VACA MUERTA FORMATION|BERRIASIAN-VALANGINIAN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38016,"idioma_id":4,"titulo":"Critical behavior of spin and chiral degrees of freedom in  three-dimensional disordered XY models studied by the nonequilibrium aging method","resumen":"The critical behavior of the gauge-glass and the XY spin-glass models in  three dimensions is studied by analyzing their nonequilibrium aging dynamics. A  new numerical method, which relies on the calculation of the two-time  correlation and integrated response functions, is used to determine both the  critical temperature and the nonequilibrium scaling exponents, both for spin  and chiral degrees of freedom. First, the ferromagnetic XY model is studied to  validate this nonequilibirum aging method (NAM), since for this nondisordered  system we can compare with known results obtained with standard equilibrium and  nonequilibrium techniques. When applied to the case of the gauge-glass model,  we show that the NAM allows us to obtain precise and reliable values of its  critical quantities, improving previous estimates. The XY spin-glass model with  both Gaussian and bimodal bond distributions, is analyzed in more detail. The  spin and the chiral two-time correlation and integrated response functions are  calculated in our simulations. The results obtained mainly for Gaussian and, to  a lesser extent, for bimodal interactions, support the existence of a  spin-chiral decoupling scenario, where the chiral order occurs at a finite  temperature while the spin degrees of freedom order at very low or zero  temperature.","palabras_clave":"SIMULATION|GLASS|DISORDERED-MODELS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38017,"idioma_id":4,"titulo":"Bromus tectorum invasion in South America: Patagonia under threat?","resumen":"Bromus tectorum (cheatgrass) is an aggressive invasivespecies posing threats to native ecosystems includingincrease in fire frequency, alteration of water andnutrient cycles and exclusion of native species. Assuch, it is important to monitor this species worldwide.However, outside the United States, it has been poorlystudied. We studied this species at two scales: (i) at alocal scale, evaluating the species presence and itsdeterminants, along the ecotonal area between thesteppe and the forest within north-western Patagonia,to reveal whether B. tectorum is actually invading naturalecosystems in areas comparable with thoseinvaded in USA, and (ii) at a regional scale, through asearch of literature and herbaria databases on B. tectorumin South America, to determine the current knowndistribution of the species in this subcontinent. Resultsindicate that it is already invading north-western Patagoniain Argentina, mainly in the semi-arid part of theregion, and that precipitation influences the invasionprocess. We found that for South America, B. tectorumhas been only documented in southern Argentinaand Chile. Given the similarities to other invadedregions, the possibility of invasion for Patagonia hasbeen predicted but not prevented. It is important tostudy changes in the invasion level where it is alreadyestablished, and to encourage managers with preventionand control strategies. Combining this informationwith lessons from places with extensive periods ofinvasion could help to initiate management of the speciesin areas where the invasion process is beginningand before the species spreads widely.","palabras_clave":"Argentina|cheatgrass| invasive species|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38018,"idioma_id":5,"titulo":"Estrategias en torno a las formas de apropiación y organización del espacio en un barrio de migrantes de la ciudad de Córdoba, Argentina","resumen":"El propósito de este trabajo es indagar sobre las estrategias de apropiación y organización del espacio que despliegan las familias peruanas en un ?barrio de migrantes? de la ciudad de Córdoba, Argentina. Este barrio, ubicado en la periferia este de la ciudad y conocido como Los Artesanos, se comenzó a consolidar como tal desde el año 2009, a partir del asentamiento de un número importante de familias migrantes que actuaron como residentes pioneros, espacialmente de origen peruano, aunque también habitan allí familias bolivianas, paraguayas y argentinas. En este análisis se busca reflexionar acerca de las distintas estrategias de supervivencia que ponen en práctica las familias migrantes en contextos de exclusión y desigualdad social, para desarrollarlo se ha optado por una metodología cualitativa que ha privilegiado la observación participante y las entrevistas en profundidad a mujeres y varones peruanos que residían en el barrio en el momento de practicarse la investigación","palabras_clave":"MIGRACIÓN PERUANA|ESPACIOS|MARGINALIDAD URBANA|CORDOBA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38020,"idioma_id":4,"titulo":"Simple fabrication of active electrodes using direct laser transference","resumen":"Direct laser transference (DLT) method is applied to obtain electrodes modified with thin films of conducting polymers (CPs) or catalytic metals. A short (6\u201310 ns) pulse of laser light (second harmonic ofNd-YAG Laser,  = 532 nm) is shined on the backside of a thin (<200 nm) film of the material to be transferred,which is deposited on a transparent substrate. The illuminated region heats up and the material(conducting polymer or metal) is thermally transferred to a solid target placed at short distance in air.In that ways, CPs are transferred onto polypropylene, glass, indium doped tin oxide (ITO), glassy carbon and gold films. In the same manner, electrocatalytic metals (platinum or gold) are transferred onto conductive substrates (glassy carbon or ITO films on glass). The films have been characterized by scanning electron microscopy, cyclic voltammetry, atomic force microscopy, UV-visible and Fourier Transform Infrared spectroscopies. The chemical, electrical and redox properties of the polymeric materials transferred remain unaltered after the transfer. Moreover, CP multilayers can be built applying DLT several times onto the same substrate. Besides polyaniline, it is shown that it is also possible to transfer functionalized polyanilines. The electrode modified with transferred Pt shows electrocatalytic activity toward methanol oxidation while ferricyanide shows a quasireversible behavior on electrodes modified with transferred Au. The method is simple and fast, works in air without complex environmental conditions and can produce active electrodes on different conductive materials. It only requires a pulsed high power Nd-YAG laser, which presently is available at low cost, and thin films on transparent substrata as source. In this way DLT seems to be a general and straightforward method to build technological devices based on CPs and\/or electrocatalytic metals including electrodes for direct methanol fuel cells and sensors.","palabras_clave":"MODIFIED ELECTRODE|LASER ABLATION|POLYANILINE|NOBEL METALS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38021,"idioma_id":4,"titulo":"Characterization of Toxoplasma gondii subtelomeric-like regions: identification of a long-range compositional bias that is also associated with gene-poor regions","resumen":"Background: Chromosome ends are composed of telomeric repeats and subtelomeric regions, which are patchworks of genes interspersed with repeated elements. Although chromosome ends display similar arrangements in different species, their sequences are highly divergent. In addition, these regions display a particular nucleosomal composition and bind specific factors, therefore producing a special kind of heterochromatin. Using data from currently available draft genomes we have characterized these putative Telomeric Associated Sequences in Toxoplasma gondii.Results: An all-vs-all pairwise comparison of T. gondii assembled chromosomes revealed the presence of conserved regions of &#8764; 30 Kb located near the ends of 9 of the 14 chromosomes of the genome of the ME49 strain. Sequence similarity among these regions is &#8764; 70%, and they are also highly conserved in the GT1 and VEG strains. However, theyare unique to Toxoplasma with no detectable similarity in other Apicomplexan parasites. The internal structure of these sequences consists of 3 repetitive regions separated by high-complexity sequences without annotated genes, except for a gene from the Toxoplasma Specific Family. ChIP-qPCR experiments showed that nucleosomes associated to these sequences are enriched in histone H4 monomethylated at K20 (H4K20me1), and the histone variant H2A.X, suggesting that they are silenced sequences (heterochromatin). A detailed characterization of the base composition of these sequences, led us to identify a strong long-range compositional bias, which was similar to that observed in other genomic silenced fragments such as those containing centromeric sequences, and was negatively correlated to gene density.Conclusions: We identified and characterized a region present in most Toxoplasma assembled chromosomes. Based on their location, sequence features, and nucleosomal markers we propose that these might be part of subtelomeric regions of T. gondii. The identified regions display a unique trinucleotide compositional bias, which is shared (despitethe lack of any detectable sequence similarity) with other silenced sequences, such as those making up the chromosome centromeres. We also identified other genomic regions with this compositional bias (but no detectable sequence similarity) that might be functionally similar.","palabras_clave":"Toxoplasma|telomeros|cromatina|bioinformatica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38022,"idioma_id":4,"titulo":"Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium","resumen":"The response of ryanodine receptor (RyR) channels to cytoplasmic free calcium concentration ([Ca2+]) is redoxsensitive. Here, we report the effects of a mild oxidative stress on cardiac RyR (RyR2) channels in Langendorffperfused rat hearts. Single RyR2 channels fromcontrol ventricles displayed the same three responses to Ca2+ reportedin other mammalian tissues, characterized by low, moderate, or high maximal activation. A single episodeof 5 min of global ischemia, followed by 1 min of reperfusion, enhanced 2.3-fold the activity of NOX2 comparedto controls and changed the frequency distribution of the different responses of RyR2 channels to calcium, favoringthe more active ones: high activity response increased and low activity response decreased with respect tocontrols. This change was fully prevented by perfusion with apocynin or VAS 2870 before ischemia and totallyreversed by the extension of the reperfusion period to 15 min. In vitro activation of NOX2 in control SR vesiclesmimicked the effect of the ischemia\/reperfusion episode on the frequencies of emergence of single RyR2 channelresponses to [Ca2+] and increased 2.2-fold the rate of calcium release in Ca2+-loaded SR vesicles. In vitro changeswere reversed at the single channel level by DTT and in isolated SR vesicles by glutaredoxin. Our results indicatethat in whole hearts a mild oxidative stress enhances the response of cardiac RyR2 channels to calciumvia NOX2activation, probably by S-glutathionylation of RyR2 protein. This change is transitory and fully reversible, suggestinga possible role of redox modification in the physiological response of cardiac RyR2 to cellular calcium influx","palabras_clave":"NOX2|ISOLATED HEARTS|RYR2 CHANNELS|CYTOPLASMATIC CALCIUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38023,"idioma_id":4,"titulo":"MODULATION OF THE CARDIAC SODIUM\/BICARBONATE COTRANSPORTER BY THE RENIN ANGIOTENSIN ALDOSTERONE SYSTEM: PATHOPHYSIOLOGICAL CONSEQUENCES.","resumen":"The sodium\/bicarbonate cotransporter (NBC) is one of the major alkalinizing mechanisms in the cardiomyocytes. It has been demonstrated the existence of at least two functional isoforms, one that promotes the co-influx of 1 molecule of Na+ per 1 molecule of HCO3- (electroneutral isoform; NBCn1) and the other one that generates the co-influx of 1 molecule of Na+ per 2 molecules of HCO3- (electrogenic isoform; NBCe1). Both isoforms are important to maintain intracellular pH (pHi) and sodium concentration ([Na+]i). In addition, NBCe1 generates an anionic repolarizing current that modulates the action potential duration (APD). The renin-angiotensin-aldosterone system (RAAS) is implicated in the modulation of almost all physiological cardiac functions and is also involved in the development and progression of cardiac diseases. It was reported that angiotensin II (Ang II) exhibits an opposite effect on NBC isoforms: it activates NBCn1 and inhibits NBCe1. The activation of NBCn1 leads to an increase in pHi and [Na+]i, which indirectly, due to the stimulation of reverse mode of the Na+\/Ca2+ exchanger (NCX), conduces to an increase in the intracellular Ca2+ concentration. On the other hand, the inhibition of NBCe1 generates an APD prolongation, potentially representing a risk of arrhythmias. In the last years, the potential altered NBC function in pathological scenarios, as cardiac hypertrophy and ischemia-reperfusion, has raised increasing interest among investigators. This review attempts to draw the attention on the relevant regulation of NBC activity by RAAS, since it modulates pHi and [Na+]i, which are involved in the development of cardiac hypertrophy, the damage produced by ischemia-reperfusion and the generation of arrhythmic events, suggesting a potential role of NBC in cardiac diseases.","palabras_clave":"sodium-bicarbonate cotransport|heart|angiotensin II|aldosterone"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38024,"idioma_id":4,"titulo":"COUNTABLE CONTRACTION MAPPINGS IN METRIC SPACES: INVARIANT SETS AND MEASURES","resumen":"We consider a complete metric space $(X,d)$ and a countable numberof \\contraction~on $X$, $\\FF=\\{F_i:i\\in\\N\\}$. We show the existenceof a {\\em smallest} invariant set (with respect to inclusion) for$\\FF$. If the maps $F_i$ are of the form $F_i(\\x) = r_i \\x + b_i$ on$X=\\R^d$, we can prove a converse of the classic result on\\contraction. Precisely, we can show that for that case, thereexists a {\\em unique} bounded invariant set if and only if $r =\\sup_i r_i$ is strictly smaller than $1$. Further, if $\\rho = \\{\\rho_k\\}_{k\\in \\N}$ is aprobability sequence, we show that if there exists an invariantmeasure for the system $(\\FF,\\rho)$, then it's support must beprecisely this smallest invariant set. If in addition there exists any {\\em bounded} invariant set, thisinvariant measure is unique - even though there may be more than one invariant set.","palabras_clave":"Countable Iterated Function Systems|Invariant Measure|Atractor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38025,"idioma_id":4,"titulo":"Direct laser interference patterning of polystyrene films doped with azo dyes, using 355 nm laser light","resumen":"The generation of line-like periodic patterns by direct laser interference patterning (DLIP) of polystyrene films (PS) at a wavelength of 355 nm has been investigated. No structuration is achieved in plain PS due to the weak absorption of the polymer at 355 nm. On the other hand, patterning is achieved on films doped (PSd) with an azo dye (2-anisidine&#61614;2-anisidine) which is incorporated in the polymer solution used for film preparation. Periodic microstructures are generated. DLIP on PSd results in the swelling of the surface at low fluences, while at high laser intensities it causes the ablation of the regions at the interference maxima positions. The results contrast with the usual process of DLIP on PS (at shorterwavelengths, like 266 nm) where only  ablation is detected. The results suggests that decomposition of the azo dye is the driving force of the patterning which therefore differ from the patterning obtained when plain PS is irradiated with laser light able to be absorbed by the aromatic ring in PS (e.g. 266 nm).The biocompability of these materials and adhesion of cells was tested, the data from in vitro assays shows that fibroblast cells are attached and proliferate extensively on the PSd films","palabras_clave":"LASER INTERFERENCE|POLYSTYRENE FILMS|PERIODIC MICROSTRUCTURES|AZO DYE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38026,"idioma_id":4,"titulo":"Star forming regions linked to RCW 78 and the discovery of a new IR bubble","resumen":"Aims. With the aim of investigating the presence of molecular and dust clumps linked to two star forming regions identified in the expanding molecular envelope of the stellar wind bubble RCW&#8201;78, we analyzed the distribution of the molecular gas and cold dust.Methods. To accomplish this study we performed dust continuum observations at 870 &#956;m and 13CO(2?1) line observations with the Atacama Pathfinder EXperiment (APEX) telescope, using the Large Apex BOlometer CAmera (LABOCA) and SHeFI-1 instruments, respectively, and analyzed Herschel images at 70, 160, 250, 350, and 500 &#956;m.  Results. These observations allowed us to identify cold dust clumps linked to region B (that we have named the southern clump) and region C (clumps 1 and 2), and an elongated filament. Molecular gas was clearly detected linked to the southern clump and the filament. The velocity of the molecular gas is compatible with the location of the dense gas in the expanding envelope of RCW&#8201;78. We estimate dust temperatures and total masses for the dust condensations from the emissions at different wavelengths in the far-IR and from the molecular line using local thermodynamic equilibrium and the virial theorem. Masses obtained through different methods agree within a factor of 2?6. Color?color diagrams and spectral energy distribution analysis of young stellar objects (YSOs) confirmed the presence of intermediate and low-mass YSOs in the dust regions, indicating that moderate star formation is present. In particular, a cluster of IR sources was identified inside the southern clump. The IRAC image at 8 &#956;m revealed the existence of an infrared dust bubble of 16&#8242;&#8242; in radius probably linked to the O-type star HD&#8201;117797 located at 4 kpc. The distribution of the near- and mid-IR emission indicate that warm dust is associated with the bubble.","palabras_clave":"ISM|star formation|RCW78"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38027,"idioma_id":4,"titulo":"Modelling interventions during a dengue outbreak","resumen":"We present a stochastic dynamical model for the transmission of dengue that considersthe co-evolution of the spatial dynamics of the vectors (Aedes aegypti) and hosts (humanpopulation), allowing the simulation of control strategies adapted to the actual evolution ofan epidemic outbreak. We observed that imposing restrictions on the movement of infectedhumans is not a highly effective strategy. In contrast, isolating infected individuals with highlevels of compliance by the human population is efficient even when implemented with delays during an ongoing outbreak. We also studied insecticide-spraying strategies assuming different (hypothetical) efficiencies. We observed that highly efficient fumigation strategies seem to be effective during an outbreak. Nevertheless, taking into account the controversial results on the use of spraying as a single control strategy, we suggest that carrying out combined strategies of fumigation and isolation during an epidemic outbreak should account for a suitable strategy for the attenuation of epidemic outbreaks.","palabras_clave":"DENGUE FEVER|INFECTIOUS DISEASE CONTROL|SPATIAL MODELLING|OUTBREAKS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38028,"idioma_id":4,"titulo":"An experimental and DFT study of a disulfide-linked Schiff base: Synthesis, characterization and crystal structure of bis (3-methoxy-salicylidene-2-aminophenyl) disulfide in its anhydrous and monohydrate forms","resumen":"A detailed structural and spectroscopic study of the disulfide Schiff base obtained from condensation of2-aminothiophenol and o-vanillin is reported. It includes the analyses of the anhydrous and monohydrateforms of the title compound. Structures of both solids were resolved by X-ray diffraction methods. A com-parison between experimental and theoretical results is presented. The conformational space wassearched and geometries were optimized both in gas phase and including solvent effects. Vibrational(IR and Raman) and electronic spectra were measured and assigned with the help of computationalmethods based on the Density Functional Theory. Calculated MEP-derived atomic charges were calcu-lated to predict coordination sites for metal complexes formation.","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38029,"idioma_id":4,"titulo":"Milk-derived angiotensin-I-converting enzyme inhibitory peptides generated by Lactobacillus delbrueckii subsp. lactis CRL 581","resumen":"Several strains of Lactobacillus helveticus and Lactobacillus delbrueckii subsp. lactis were evaluated for their ability to release angiotensin-I-converting enzyme (ACE) inhibitory peptides from &#945;-casein (&#945;-CN) and &#946;-casein (&#946;-CN). Casein peptides resulting from L. delbrueckii subsp. lactis CRL 581-mediated hydrolysis exhibited the highest ACE-inhibitory (ACEI) activities, with values of 53 and 40% for &#945;-CN and &#946;-CN, respectively. The casein hydrolysates were fractionated by reversed-phase high pressure liquid chromatography and some of the active peptides were identified by mass spectrometry. The fraction with the highest ACEI activity arose from &#946;-CN and contained a mixture of the &#946;-CN f194-206 (QEPVLGPVRGPFP) and f198-206 (LGPVRGPFP) peptides. Furthermore, the ACEI tripeptide IPP was identified in all &#946;-CN hydrolysates; L. delbrueckii subsp. lactis CRL 581 produced the highest amount of this peptide. The bioactive peptides released by CRL 581 strain may be used in the formulation of functional foods and nutraceuticals, representing a healthier and natural alternative for regulating blood pressure.","palabras_clave":"LACTIC ACID BACTERIA|PROTEINASE|ACE INHIBITORY PEPTIDES|CASEIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38030,"idioma_id":4,"titulo":"Haplotype determination of the upstream regulatory region and the second exon of the BoLA-DRB3 gene in Holstein cattle","resumen":"Polymorphisms of the BoLA-DRB3 gene are located primarily in the second exon (antigen binding site) and, to a lesser extent, in the upstream regulatory region (URR). It can be hypothesised that exon 2 and the URR are under different types of natural selection. The aim of the present work was to determine the URR-exon 2 haplotypes; 34 Holstein samples were genotyped by direct sequencing. Seven URR alleles and twenty-three exon 2 alleles were detected, and three of the URR alleles were novel. Our results may suggest that no relationship exists between the URR and exon 2 of the BoLA-DRB3 gene (Linkage disequilibrium p value &gt; 0.05), most likely due to recombination over time. Our results also suggest that both regions of class II genes may be included in the development of new genotyping methods based on next-generation DNA sequencing technologies.","palabras_clave":"BoLA-DRB3|linkage disequilibrium|polymorphism|selection"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38031,"idioma_id":4,"titulo":"An Insight into the Transcriptome of the Digestive Tract of the Bloodsucking Bug, Rhodnius prolixus","resumen":"The bloodsucking hemipteran Rhodnius prolixus is a vector of Chagas´ disease, which affects 7-8 million people today in Latin America. In contrast to other hematophagous insects, the triatomine gut is compartmentalized into three segments that perform different functions during blood digestion. Here we report analysis of transcriptomes for each of the segments using pyrosequencing technology. Comparison of transcript frequency in digestive libraries with a whole-body library was used to evaluate expression levels. All classes of digestive enzymes were highly expressed, with a predominance of cysteine and aspartic proteinases, the latter showing a significant expansion through gene duplication. Although no protein digestion is known to occur in the anterior midgut (AM), protease transcripts were found, suggesting secretion as pro-enzymes, being possibly activated in the posterior midgut (PM). As expected, genes related to cytoskeleton, protein synthesis apparatus, protein traffic, and secretion were abundantly transcribed. Despite the absence of a chitinous peritrophic membrane in hemipterans - which have instead a lipidic perimicrovillar membrane lining over midgut epithelia - several gut-specific peritrophin transcripts were found, suggesting that these proteins perform functions other than being a structural component of the peritrophic membrane. Among immunity-related transcripts, while lysozymes and lectins were the most highly expressed, several genes belonging to the Toll pathway - found at low levels in the gut of most insects - were identified, contrasting with a low abundance of transcripts from IMD and STAT pathways. Analysis of transcripts related to lipid metabolism indicates that lipids play multiple roles, being a major energy source, a substrate for perimicrovillar membrane formation, and a source for hydrocarbons possibly to produce the wax layer of the hindgut. Transcripts related to amino acid metabolism showed an unanticipated priority for degradation of tyrosine, phenylalanine, and tryptophan. Analysis of transcripts related to signaling pathways suggested a role for MAP kinases, GTPases, and LKBP1\/AMP kinases related to control of cell shape and polarity, possibly in connection with regulation of cell survival, response of pathogens and nutrients. Together, our findings present a new view of the triatomine digestive apparatus and will help us understand trypanosome interaction and allow insights into hemipteran metabolic adaptations to a blood-based diet.","palabras_clave":"TRANSCRIPTOMIC|RHODNIUS PROLIXUS|ANNOTATION|DIGESTIVE TRACT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38032,"idioma_id":4,"titulo":"Intra- and extra-cellular DNA damage by harmine and 9-methyl-harmine","resumen":"It is known that  &#946;-carbolines are able to produce photosensitized damage in cell-free DNA, but  there is little information on their effects on cellular DNA. Therefore, we  have analyzed the DNA damage produced by harmine and 9-methyl-harmine under UVA  irradiation in V79 cells, together with the associated generation of  micronuclei and photocytotoxicity. The results indicate that the most frequent  photoproducts generated in the cellular DNA are modified purines such as  8-oxo-7,8-dihydroguanine. Only relatively few single-strand breaks were  observed. CPDs were absent, although they were generated in cell-free DNA irradiated  under the same conditions. The overall extent of DNA damage in the cells was  considerably smaller than the one observed in cell free DNA. The generation of  cellular DNA damage was associated with a significant generation of micronuclei  and decreased cell proliferation. The data indicate that &#946;-carbolines act as  photosensitizers in mammalian cells. The spectrum of DNA modification, and  therefore the mechanism of DNA damage generation, differs considerably from  that observed with cell-free DNA.","palabras_clave":"DNA|photosensitization|alkaloids|b-carbolines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38033,"idioma_id":4,"titulo":"First-principles studies concerning optimization of hydrogen storage in nanoporous reduced graphite oxide","resumen":"By means of Density Functional Theory (DFT) calculations we investigated the optimal poresize for reduced graphite oxide (GOH) to favor hydrogen storage and to prevent oxygeninterference. The interlayer distance of GOH is found to increase with oxygen content,given by the number of hydroxyl groups. Four types of GOHs were considered, with O\/Cratio within a 0.09e0.38 range. In the case of the highest O\/C ratio considered, 0.38, aspontaneous redox-reaction between hydroxyl groups delivering a water molecule and anepoxy group was found. Thus, GOHs with high O\/C ratio are not recommended forhydrogen storage. In these materials the absorption energy values of hydrogen is in therange of 0.2 and 0.5 eV\/molecule, that is within the values expected to allow an efficientstorage. The best GOH for hydrogen storage was found to be that with a 0.09 O\/C ratio sinceit has the largest void space and adequate absorption energy, 0.52 eV\/molecule. On theother hand, oxygen absorption energy is lower in absolute value than that of hydrogen,which favors absorption of the latter, thus creating adequate conditions for its storagewithout oxygen interference.","palabras_clave":"HYDROGEN STORAGE|REDUCED GRAPHITE OXIDE|NANOPOROUS MATERIAL|DENSITY FUNCTIONAL THEORY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38034,"idioma_id":4,"titulo":"lmdme: Linear Model on Designed Multivariate Experiments in R","resumen":"The lmdme package implements analysis of variance (ANOVA) decomposition through linear models on designed multivariate experiments in R (R Development Core Team 2012), allowing ANOVA-principal component analysis (APCA) and ANOVA-simultaneous component analysis (ASCA). It also extends both methods with the application of partial least squares (PLS) through the specication of a desired output matrix. The package is freely available on the Bioconductor website (Gentleman et al. 2004), licenced under GNU general public license.  ANOVA decomposition methods for multivariate designed experiments are becoming popular in omics' experiments (transcriptomics, metabolomics, etc.) where measure-ments are performed according to a predened experimental design (Smilde et al. 2005), with several experimental factors or including subject specic clinical covariates, such as those present in current clinical genomic studies. ANOVA-PCA and ASCA are well-suited methods to study interaction patterns on multidimensional datasets. However, current R implementation of APCA is only available for Spectra data (ChemoSpec), meanwhile ASCA (Nueda et al. 2007) is based on average calculations over the indexes of up to three design matrices. Thus, no statistical inference over estimated eects is provided. Moreover, ASCA is not available in R package format.  Here, R implementation on ANOVA decomposition with PCA\/PLS analysis is provided. It allows a flexible formula interface the specication on almost any linear model with appropriate inference over the estimated effects  and display functions for both PCA and PLS.  We will present the model, implementation and two high-throughput microarray examples: one applied on interaction pattern analysis and the other for quality assessment.","palabras_clave":"ANOVA|PCA|APCA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38035,"idioma_id":4,"titulo":"Spectroscopic, electrochemical and computational studies of rhenium(I) and ruthenium(II) complexes incorporating the novel tetradentate ligand 1,4-bis(4-(4'-methyl)-2,2'-bipyridyl)-2,3-diaza-1,3-butadiene (BBDB) and its derivatives","resumen":"The novel tetradentate ligand 1,4-bis(4-(40-methyl)-2,20-bipyridyl)-2,3-diaza-1,3-butadiene (BBDB) was synthesized and characterized by spectroscopic techniques. New complexes of Re and Ru of formulae:  [Re(BBDB)(CO)3(Cl)], [(CH3CN)(CO)3Re(l-BBDB)Re?(CO)3(CH3CN)]2+, [(bpy)2Ru-(l-BBDB)Ru(bpy)2]4+,[(NH3)4Ru(l-BBDB)?Ru(NH3)4]4+ (bpy = 2,20-bipyridine) and complexes of Ru with 4-Me-40-CO2H-bpy (=4-methyl-40-carboxylic acid-2,20-bipyridine) ? the hydrolyzed derivative of BBDB ? of formulae:[(Ru(4-Me-40-CO2H-bpy)(bpy)2]2+ and [Ru(4-Me-40-CO2H-bpy)(CN)4]2 were prepared and characterized by spectroscopic,electrochemical and computational techniques. The disclosed enhanced electronic coupling  in the mixed-valent complex with ruthenium ammines can be explained by the electronic delocalization imposed by the AC@NAN@CA backbone. DFT and TD-DFT calculations can predict the optical properties and electronic structures of the reported complexes and comparisons with calculations performed on previously reported complexes with 4-pyridinaldazine can account for their photophysical behaviour.","palabras_clave":"Diazabutadiene|Rhenium|Ruthenium|MO calculations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38036,"idioma_id":4,"titulo":"Chlamydia trachomatis in a girl suspected of sexual abuse in the city of Cordoba, Argentina","resumen":"Chlamydia trachomatis (C.tr) infections are the  most prevalent bacterial sexually transmitted  infections worldwide. They are often asymptomatic  and therefore underdiagnosed as there is  no routine screening surveillance. This case  supports the possibility of sexual abuse as a  route of transmission of C.tr. It is well known  that nearly one third of sexually assaulted  children are at risk for infection by a sexually  transmitted agent. This is why in cases of sexual  abuse, it is standardized that C.tr positive results  by Nucleic Acid Amplification Techniques  (NAATs) should be confirmed looking for  another C.tr target; for this reason, we used a  Polimerase Chain Reaction (PCR) directed to  cryptic plasmid of C.tr. Confirmation was specified  by the use of another PCR with a different  genetic target (ompA) and sequencing. We concluded  that our patient?s oral lesions were probably  originated by her father?s sexual abuse.","palabras_clave":"Chlamydia trachomatis|Sexual Abuse|Girl|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38037,"idioma_id":4,"titulo":"Heavy metal accumulation in leaves of aquatic plant Stuckenia filiformis and its relationship with sediment and water in the Suquía river (Argentina)","resumen":"In order to evaluate the Stuckenia filiformis plant species as an indicator organism of heavy metal pollution in biomonitoring studies of the aquatic ecosystem, the aim of this study was to determine the levels of heavy metal accumulation (Co, Cu, Fe, Mn, Ni, Pb and Zn) in leaves of the submerged macrophyte S. filiformis and the possible relationship of the concentrations of these metals with those found in surface water and sediment samples of the Suquía river. Sampling was carried out in July 2006 and February 2009, during the dry and wet seasons, respectively, at 7 sampling sites where three replicates of surface water, sediment and S. filiformis plants were collected. Cobalt, Ni and Zn in surface water were significantly higher in the samples collected in 2006 than in 2009. In sediment, the concentrations of Co, Cu, Ni, Pb and Zn, along with organic matter, were significantly higher in 2006, while those of Fe were significantly greater in 2009. Copper and Pb exceeded the limits established for the protection of aquatic life by national (Cu: 2.0 mg L-1, Pb: 2.0 mg L-1) and international organizations (Cu: 1.6 mg L-1, Pb: 2.5 mg L-1) in surface water, while in sediment, Zn exceeded the limit for ecological screening levels (Zn: 121.0 mg kg-1) in 2006. In the surface water and sediment samples, heavy metal concentrations were found to be higher downstream of Córdoba city (Sites 6 and 7) in both sampling campaigns, probably related to the contribution of pollutants from the effluent discharge of a wastewater treatment plant and industrial activities of the city. The aquatic plant S. filiformis showed a high capacity to accumulate heavy metals in its tissues, in areas of the river where higher values of heavy metals in the abiotic compartments surface water and sediments were observed. Copper, Pb and Zn incorporated as contaminants in surface water and sediments were able to be removed by S. filiformis by self-purification processes. Therefore, this species could be proposed as a suitable heavy metal bioindicador for the early stages of pollution in rivers.","palabras_clave":"STUCKENIA FILIFORMIS|BIOACCUMULATION|HEAVY METALS|SUQUÍA RIVER|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38038,"idioma_id":4,"titulo":"Study of hydrogen adsorption properties on MCM- 41 mesoporous materials modified with nickel","resumen":"MCM-41 samples were modified with different Ni loadings by wet impregnation method and characterized by XRD, ICP, EPMA-EDS, N2 adsorptionedesorption and hydrogen adsorption at 77 K at high and low pressure conditions. The hydrogen adsorption studies for the MCM-41 host and the impregnated samples showed that small amounts of Ni ions in MCM-41 improved the hydrogen storage capacity by spillover effect.","palabras_clave":"MCM-41|Nickel|Hydrogen storage"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38039,"idioma_id":4,"titulo":"Analysis of variation for apomictic reproduction in diploid Paspalum rufum","resumen":"Background and Aims The diploid cytotype of Paspalum rufum (Poaceae) reproduces sexually and is self-sterile; however, recurrent autopolyploidization through 2n + n fertilization and the ability for reproduction via apomixis have been documented in one genotype of the species. The objectives of this work were to analyse the variation in the functionality of apomixis components in diploid genotypes of P. rufum and to identify individuals with contrasting reproductive behaviours. ? Methods Samples of five individuals from each of three natural populations of P. rufum (designated R2, R5 and R6) were used. Seedswere obtained after open pollination, selfing, conspecific interploidy crosses and interspecific interploidy self-pollination induction. The reproductive behaviour of each plant was determined by using the flow cytometric seed screen (FCSS) method.Embryo sacswere cleared using a series of ethanol and methyl salicylate solutions and observed microscopically.? Key Results In open pollination, all genotypes formed seeds by sexual means and no evidence of apomeiotic reproduction was detected. However, in conspecific interploidy crosses and interspecific interploidy self-pollination induction, variations in the reproductive pathways were observed. While all plants from populations R2 and R6 formed seeds exclusively by sexual means, three genotypes from the R5 population developed seeds from both meiotic and aposporous embryo sacs, and one of them (R5#49) through the complete apomictic pathway (apospory + parthenogenesis + pseudogamy). Cytoembryological observations revealed the presence of both meiotic and aposporous embryo sacs in all the genotypes analysed, suggesting that parthenogenesis could be uncoupled from apospory in some genotypes.?Conclusions The results presented demonstrate the existence of variation in the functionality of apomixis components in natural diploid genotypes of P. rufum and have identified individuals with contrasting reproductive behaviours. Genotypes identified here can be crossed to generate segregating populations in order to study apomixis determinants at the diploid level. Moreover, analysis of their expression patterns, quantification of their transcript levels and an understanding of their regulation mechanisms could help to design new strategies for recreating apomixis in a diploid genome environment.","palabras_clave":"APOMIXIS|SEED DEVELOPMENT|DIPLOID GENOTYPE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38040,"idioma_id":4,"titulo":"Development of a modified transformation platform for apomixis candidate genes research in Paspalum notatum (bahiagrass)","resumen":"The aim of this work was to improve existingtransformation protocols and to transform specific genotypesof Paspalum notatum (bahiagrass) for functional analyses ofcandidate genes involved in reproduction. Three differentexplants were assayed for in vitro plant regeneration: matureseeds, mature embryos, and shoot meristems. Plant regenerationwas achieved with all explant types, but mature seedsproduced the optimal rate (78.0%) and were easiest to manipulate.A method based on serial re-induction of calli frommeristems of the regenerated lines was also developed, whichcould be useful in plant breeding strategies pursuingsomaclonal variation. Transient transformation experimentswere performed on calli obtained from mature seeds using acompressed helium gene gun. Transient transformation constructsincluded anthocyanin-synthesis genes cloned under theCAMV 35S promoter and an enhanced green fluorescentprotein gene (egfp) driven by the rice actin1 (act1) promoter.Selection curves for ammonium glufosinate were developedin order to determine the optimal selective pressure for stabletransformation (1.0 mg\/L). Stable co-transformation experimentswere carried out with two different constructs containing:(1) the reporter egfp gene cloned under the rice act1promoter and (2) the selector bar gene driven by the ubiquitinpromoter. A total of 27 (64.2%) transgenic plants out of 42resistant plants analyzed were obtained. The presence of thetransgenes in regenerated plants was confirmed bypolymerase chain reaction and DNA gel blot analysis. Geneexpression was demonstrated by eGFP fluorescence detectionand in vivo assays for ammonium glufosinate tolerance. Thisplatform is being used to generate transgenic plants ofP. notatum to analyze the function of apomixis-associatedcandidate genes.","palabras_clave":"Biolistic transformation|Paspalum notatum|Ammoniun gluphosinate|Egfp|Apomixix"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38041,"idioma_id":4,"titulo":"Striped, bioactive Ce-TiO2 material with peroxynitrite-scavenging activity","resumen":"Controlling aligned fiber micro-architectures to simulate extracellular matrix inducing important biological functions is a key challenge in regard to successful tissue regeneration. Here we present a bottom-up microemulsion mediated strategy to obtain highly bioactive and biocompatible, striped Ce-TiO2 nano-crystalline superstructures with ONOO- scavenging activity. The employment of a bulkier organic ceria precursor on the material synthesis has several concurrently effects: (I) influencing the interfacial microemulsion droplet elasticity to create an aligned distribution of prismatic anatase nano-particles causing the final lined morphology; (II) stabilizing the anatase active phase in a fine dispersed state and improving it resistance to the thermal anatase-rutile conversion; (III) indirectly favoring the rapid formation on the material surface of a hydroxyapatite layer composed of spherical-like globules with 3-5 &#956;m in diameter essential for bone-bonding; and finally (IV) accelerating the ONOO- degradation to a less harmful species NO2- and O2.","palabras_clave":"TITANIO|CERIO|IMPLANTES|HUESO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38042,"idioma_id":4,"titulo":"Study of diversity in a set of lentil RILs using morphological and molecular markers","resumen":"We propose the use of SRAP and SSR markers along agronomic or morphological traits in genotypes? differentiation during breeding programs. 25 F5 recombinant inbred lines (microsperma and macrosperma) with good quality characteristics and high yield and a tester were used. All materials were sowed in a randomized block design with 3 replications, at a density of 140 plants per m2. Different morphological traits were recorded and analyzed using ANOVA. Euclidean distances were calculated and a cluster analysis and a principal components analysis (PCA) were carried out. A total of 20 out of 25 SRAP combinations and 9 out of 17 SSR were assayed on the basis of their high polymorphism. Genetic distances were calculated according to Dice?s similarity index and a dendrogram was performed. A comparison between morphological and molecular data was carried out through the procrustes generalized analysis. The analysis of variance for morphological traits showed significant differences between genotypes for all variables. The analysis of principal components determined that two PCs explained 75% of the total variation observed among the genotypes and the cluster analysis allowed the conformation of two principal groups. The first one included four varieties belonging to the microsperma type, whereas the second group included all the macrosperma type Rils. Both groups showed differences also in yield and plant height. Molecular analysis showed that 66% out of 273 bands are polymorphic fragments from SRAP markers, indicating a high genetic diversity among Rils. The number of alleles per SSR locus ranged from 3 (SSR 33) to 7 (SSR 156) showing also the variability present. Two exclusive SRAP fragments generated by the combination me5-em1 (230 bp) were found in microsperma group allowing early selection of this trait and all characters associated with it. The correlation between Dice similarity index and Euclidean distance matrices was 87% indicating an excellent consistency between both types of markers and suggested that both types of traits would provide similar estimates on the variability and would be useful to differentiate Rils with similar origin.","palabras_clave":"Lentil|molecular markers|morphological traits|genetic distance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38043,"idioma_id":4,"titulo":"WR 35a: A new double-lined spectroscopic binary","resumen":"Aims: We present the first orbital solution for the Wolf-Rayetstar, WR 35a, that was discovered by a spectroscopic monitoring of faintWN-type stars.  Methods: Spectral features of two differentcomponents were identified, and thus a method of disentangling theindividual spectra of both components was applied. Radial velocitieswere determined for each component in the binary system.  Results:The orbital solution and component properties of the system werederived. We determined that WR 35a is composed of a WN6 star with a O8.5V companion orbiting at a 41.90-day period.","palabras_clave":"binaries: spectroscopic|stars: individual: WR 35a|stars: Wolf-Rayet"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38044,"idioma_id":4,"titulo":"Triggered star formation in a molecular shell created by a SNR?","resumen":"We present a study of a new molecular shell, G 126.1-0.8-14, usingavailable multiwavelength Galactic plane surveys and optical Geminiobservations. A well-defined shell-like structure is observed in theCO(1-0) line emission at (l,b) = (126.1°, -0.7°), in thevelocity range -10.5 to -15.5 km s-1. The H I emission showsa region of low emissivity inside G 126.1-0.8-14, while radio continuumobservations reveal faint non-thermal emission possibly related to thisshell. Optical spectra obtained with Gemini South show the existence ofB-type stars likely to be associated with G 126.1-0.8-14. An estimate ofthe stellar wind energy injected by these stars shows that they alonecannot be able to create such a structure. On the other hand, onesupernova explosion would provide enough energy to generate the shell.Using the MSX, IRAS and WISE point source catalogues we have found about30 young stellar object candidates, whose birth could have beentriggered by the expansion of G 126.1-0.8-14. In this context, Sh2-187could be a consequence of the action on its surroundings of the mostmassive (and thus most evolve) of the stars formed by the expandingmolecular shell.","palabras_clave":"stars: formation|stars: massive|H II regions|ISM: kinematics and dynamics|ISM: supernova remnants"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38045,"idioma_id":4,"titulo":"Effect of the Al\/clay ratio on the thiabendazol removal by aluminum pillared clays","resumen":"In thiswork, four aluminumpillared clays (Al-PILC)with different Al\/clay ratioswere synthesized and evaluated for the removal of thiabendazole (TB) (a fungicide widely used in agricultural activities) from aqueous media. The Al-PILC were thoroughly characterized by different techniques, such as X-ray diffraction (XRD), thermogravimetric analysis (DTA-TG), adsorption\u2013desorption of N2 at 77 K, NH3-temperature programmed desorption (NH3-TPD) and transmission electron microscopy (TEM). The TB-adsorption studies were carried out in batch, at room temperature, at pH = 6 (natural pH, without additional control) and with different concentrations of TB (2\u2013100 ppm). The measured TB adsorption capacities varied from 11.78 to 17.50 mg TB per gram of clay.  The TB\u2013Al PILC complexes obtained after the adsorption process were studied by X-ray photoelectron spectroscopy (XPS). The results suggested that the molecules of TB were adsorbed on the Al-PILC by two different phenomena: by physisorption in their porous structure and by  hemisorption on their pillars, showing a concordance between the amounts of incorporated aluminumin the pillared clays and their fungicide adsorption capacity.","palabras_clave":"Fungicide adsorption |Thiabendazole |Aluminum pillared clay |Adsorbents"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38046,"idioma_id":4,"titulo":"A straightforward method for tuning of Lyapunov-based controllers in semi-active vibration control applications","resumen":"Lyapunov-based control is an attractive strategy for semi-active vibration control as it has  a mathematical basis ensuring stability in the sense of Lyapunov and great flexibility in  the design. Unfortunately, that flexibility complicates the controller tuning since it  involves the construction of a weighting matrix, which is usually done by trial-and-error.  In this work, a straightforward (closed form) method to construct such a matrix is  proposed. The proposed method is based on penalizing vibrational modes according to  their contributions to the response in the uncontrolled case. For this purpose, a new  concept of Generalized Modal Contribution Factor is developed. This takes into account  the following: spatial distribution of the excitation, knowledge of the frequency content of  the excitation, and control objective.  The capability of the proposed tuning method is demonstrated through a numericalexample","palabras_clave":"Lyapunov-based controllers|semi-active controller|semi-active vibration control"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38047,"idioma_id":4,"titulo":"Damping response of composites beams with carbon nanotubes","resumen":"Damping response of composite beams with carbon nanotubes (CNTs) have been studied carrying out free vibration tests. Simple and sandwich beams are manufactured with aluminum, epoxy resin and different types of CNTs. For comparison purposes, sandwich and simple beams with neat epoxy resin were also made and tested. 5 wt% of CNTs is added as filler in the epoxy matrix in all cases. Damping ratio is obtained by means of logarithmic decrement and half-power bandwidth method. Short aspect ratio multiwalled&nbsp; non-functionalized nanotubes are found to be the most effective for improving dampingproperties in both types of beams.","palabras_clave":"Carboncarbon composites|Vibration|Mechanical testing"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38048,"idioma_id":5,"titulo":"DESCRIPCIÓN DE LA FORMA Y FUNCIÓN DE  LA PARTICIPACIÓN DE LOS JÓVENES EN LAS  ACTIVIDADES INSTRUMENTALES DE LA VIDA DIARIA","resumen":"El siguiente artículo tiene como objetivo Identificar y describir la participación de los jóvenes en las actividades instrumentales dela vida diaria (AIVD) . Para describir la participación ocupacional de jóvenes en las actividades instrumentales de la vida diaria sehizo necesario no solamente indagar acerca de la participación, sino analizar las formas ocupacionales y funciones que las atraviesan.Se trabajó con una metodología mixta cuali-cuantitativa, con un diseño de tipo exploratorio descriptivo. La muestra quedó conformadapor 34 jóvenes. Se identificaron y describieron formas variadas de participan y de función que atraviesan cada actividad.Los resultados revelaron que todos los jóvenes participan en actividades instrumentales de la vida diaria, sin embargo ninguno deellos participa en todas las actividades que se incluyen dentro de las AIVD.En la discusión se reflexiona acerca del lugar que ocupan las AIVD tanto en relación a su clasificación, a su desarrollo, como su fin.Y se comparten algunas de las dificultades que experimentamos en el desarrollo de la investigación relacionado a la construccióndel instrumento de indagación, relevamiento de datos, clasificación y categorización","palabras_clave":"Actividades Instrumentales de la vida diaria|Juventud|Forma ocupacional|Funcion ocupacional"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38049,"idioma_id":4,"titulo":"Visible light absorption of TiO2 materials impregnated with tungstophosphoric acid ethanol-aqueous solution at different pH values. Evidence about the formation of a surface complex between Keggin anion and TiO2 surfaces","resumen":"    TiO2 particles prepared by the sol-gel  method were impregnated at different pH values (1.0, 2.0, 5.0 and 10.0) with a  water-ethanol solution (50% V\/V) of tungstophosphoric acid (TPA) (0.012 M). Similar preparation was carried out to  synthesize TiO2 impregnated with [WO4]2-  (TiW). These materials were characterized by different techniques such as  UV-Vis Diffuse Reflectance Spectroscopy (UV-Vis DRS), Magic Angle Spinning  Nuclear Magnetic Resonance of 31P (31P MAS-NMR), Fourier Transform  Infrared Spectroscopy (FT-IR), Fourier Transform Raman Spectroscopy (FT-Raman).    Results revealed that TPA-TiO2 materials  exhibit visible light absorption only when impregnation was done at pH 1.0  (TiTPA1) and 2.0 (TiTPA2). TiW powder did not show visible light absorption. &nbsp;Solid NMR, FT-IR and FT-Raman  characterization showed that TiTPA1 and TiTPA2 samples contain Keggin ([PW12O40]3-)  and lacunary anions ([PW11O39]7-) respectively.  On the other hand, FT-Raman results revealed a blue shifting and broadening of the  band at 141 cm-1 corresponding to anatase TiO2 and  moreover, a broadening of bands at 900\u20131100 cm-1 attributed to  Keggin structures of TPA. Both spectral changes could be related to the formation  of a surface complex between the Keggin anion of TPA and TiO2  surfaces. This interaction should be responsible for visible light absorption.   ","palabras_clave":"Tungstophosphoric acid|Visible light responsive TiO2|polyoxometallates|heterogeneous photocatalysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38050,"idioma_id":4,"titulo":"). Annual variation of  7Be soil inventory in a semiarid region of central Argentina","resumen":"Reliable information on environmental radionuclides atmospheric entrance, and their distribution along the soil profile, is a necessary condition for using these soil and sediment tracers to investigate key environmental processes. To address this need, 7Be content in rainwater and the wet deposition in a semiarid region at San Luis Province, Argentina, were studied. Following these researches, in the same region, we have assessed the 7Be content along a soil profile, during 2.5 years from September 2009 to January 2012. As expected, the specific activity values in soil samples in the wet period (NovembereApril) were higher than in the dry period (MayeOctober). During the investigated period (2009 e beginning 2012) and for all sampled points, the maximum value of the 7Be specific activity (Bq\/kg was measured at the surface level. A typical decreasing exponential function of 7Be areal activity (Bq\/m2) with soil mass depth (kg\/m2) was found and the key distribution parameters were determined for each month. The minimum value of areal activity was 51 Bq\/m2 in August, and the maximum was 438 Bq\/m2 in February. The relaxation mass depth ranges from 2.9 kg\/m2 in March to 1.3 kg\/m2 in August. 7Be wet deposition can explain in a very significant proportion the 7Be inventory in soil. During the period of winds in the region (September and October), the 7Be content in soil was greater than the expected contribution from wet deposition, situation that is compatible with a higher relative contribution of dry deposition at this period of the year.","palabras_clave":"7Be|7Be AREAL ACTIVITY|RELAXATION MASS DEPTH|ARID ENVIRONMENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38051,"idioma_id":4,"titulo":"Using 222Rn as a tracer of geodynamical processes in underground environments","resumen":"Radon levels in two old mines in San Luis, Argentina, were measured and analyzed, with the aim to assess the potential use of this radioactive noble gas as a tracer of geological processes in underground environments. La Carolina gold mine and Los Cóndores tungsten mine are today used as tourismmines. CR-39 nuclear track detectors  were used for this purpose. Measurements were performed during both winter and summer seasons. The findings show that in these environments, significant radon concentrations are subject to large seasonal fluctuations, due to the strong dependence on natural ventilation with the outside temperature variations. For both mines, higher concentration values of 222Rn were observed in summer than in winter; with an extreme ratio of 2.5 times between summer and winter seasons for Los Cóndores mine. The pattern of radon transport inside La Carolina mine revealed, contrary towhatwas believed, that thismine behaves as a systemwith two entrances located at different levels. However, this feature can only be observed in the winter season, when there is a  marked difference between the inside and outside temperatures of the mine. In the case of Los Cóndores mine, the radon concentration pattern distribution is principally established by air current due to chimney-effect in summer and winter seasons. In both cases, the analyses of radon pattern distribution appear as a good method to trace air currents, and then localize unknown ducts, fissures or secondary tunnels in subterranean  environments.","palabras_clave":"CHIMNEY EFFECT|RADON TRANSPORT PROCESS|CR-39 NUCLEAR TRACK DETECTORS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38052,"idioma_id":5,"titulo":"Cartografía de Cambios de cobertura del suelo (1987-1998) para el Parque Nacional Predelta (Entre Ríos, Argentina)","resumen":"Los estudios territoriales requieren de cartografía sobre el estado y dinámica de sus ecosistemas. El mapeo de la cobertura del suelo ha sido motivo de numerosas iniciativas globales (Land Cover, Globe cover) y continentales, no así para escalas regionales y locales asociadas al Parque Nacional Predelta. El objetivo del presente trabajo fue desarrollar una metodología para la cartografía de cobertura y su cambio para el Parque Nacional Predelta a partir de información espacial (datos Landsat TM) y de terreno. Se ha obtenido un mapa de cambios de cobertura de suelo para el área de estudio, entre 1987 y 1998. Igualmente se identificaron coberturas del suelo, clases de bosque, pastizales altos, praderas, suelo desnud\/infraestructuras. La confianza global fue mayor al 80%, siendo las ?clases de cambio? las de menor confianza. Se generó información para la gestión territorial.","palabras_clave":"segmentacion de imágenes|Parque Nacional Pre-Delta|LANDSAT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38053,"idioma_id":4,"titulo":"Inheritance of resistance to Mal de Río Cuarto disease in maize using recombinant inbred lines","resumen":"Mal de Río Cuarto (MRC) is a devastating disease that reduces yield, quality and economic value of maize in Argentina. The objective of the present study was to estimate the variance and heritability of resistance to MRC disease from maize families to MRC from recombinant inbred lines (RILs). Reactions to the endemic MRC disease were evaluated in 145 advanced F2:6 lines, derived from a cross between a resistant (BLS14) and a susceptible (Mo17) line, at four environments in the temperate semi-arid crop region of Argentina. The evaluations of disease score (SCO), disease incidence (INC) and disease severity (SEV) were carried out on each individual RIL. Low heritability estimates were found across environments for SCO (0.23), INC (0.27) and SEV (0.22). On the basis of the substantial genotype?environment interaction and the little association between variables values in the different environments, selection for an increased resistance to MRC disease would require evaluation of germplasm across multiple years and locations.","palabras_clave":"Mal de Río Cuarto |maize |resistance |recombinant inbred lines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38054,"idioma_id":4,"titulo":"Stalk and root rot in maize hybrids: analysis of gentoype X environment interaction using GGE biplots","resumen":"Stalk and root rot (SRR) is one of the most important maize (Zea mays L.) crop diseases in Argentina, as it is widely spread and has high incidence and severity (Buchaca, 2008). The most efficient, economical and environmentally sustainable control method involves the use of resistant genotypes. The disease presents diverse symptoms with different degrees of manifestations and incidence values among the analyzed populations. As a consequence, resistance indices have been proposed (Grau et al., 1982), such as the multidimensional indicator of stalk and root rot (MISRR). The response of the different hybrid genotypes to the disease is influenced by environmental conditions; therefore, evaluating the materials in different environments is an interesting approach. The differential behavior of genotypes in diverse environments results in a genotype × environment interaction; quantifying the magnitude of the interaction is of interest when evaluating genotype.  To describe genotype adaptability and stability, different statistical methods that explore the genotype × environment interaction and estimate it with improved accuracy have been proposed. Although the phenotypic character of interest is the result of the effects of genotype (G), environment (E) and their interaction (G×E), only the main effects of G and of G×E are relevant to genotype evaluation (Yan et al., 2000; Yan and Tinker, 2006). Unlike the analysis of variance (ANOVA) and comparison of means, which only allow us to select those genotypes that are above a given yield level, sites regression models (SREG) (Cornelius et al., 1996; Crossa and Cornelius, 1997; Crossa et al., 2002) are recommended when environment effects are an important source of variation. These models have the additional advantage of providing a graphical analysis known as GGE biplot (Yan et al., 2000; 2001). The aim of the present work was to study G×E interaction via a multidimensional indicator of SRR in maize using the GGE biplot analysis.","palabras_clave":"maize|Stalk and root rot (SRR) |resistance|genotype environment interaction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38055,"idioma_id":4,"titulo":"Characterisation of the multixenobiotic resistance (MXR) mechanism in the freshwater snail Physa acuta from Patagonia (Argentina)","resumen":"P-glycoprotein (P-gp) mediated multixenobiotic resistance (MXR) is a mechanism analogous to multidrug resistance (MDR), which has been extensively characterised in mammalian tumours. The expression and function of the MXR mechanism has been demonstrated in numerous aquatic organisms and has been proposed as a biomarker for pollution assessment.     The purpose of this study was to evaluate the activity and expression of the MXR mechanism in freshwater snails, Physa acuta, of the Andean-Patagonian region. The accumulation and efflux rates of the model P-gp substrate Rhodamine B in snails previously exposed to pollution were measured.  Results confirmed that MXR activity decreased after maintenance in clean water, and that a depuration period of 7 days was long enough to observe a significant deinduction of this system.     The results demonstrate the presence of a P-gp-like transport system in the freshwater snail Physa acuta from Patagonia, and suggest its function as a defence system. The results of this study could be used to provide information on the possible use of these snails as bioindicators in toxicological testing.","palabras_clave":"MXR|P-GLYCOPROTEIN|FRESHWATER SNAILS|PATAGONIA|BIOINDICATORS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38056,"idioma_id":4,"titulo":"On the nature of sn stars. I A detailed abundance study","resumen":"    The sn stars were first discoved by Abt &amp; Levato when studying the spectral types in different open clusters. These stars present sharp Balmer lines, sharp metallic lines (C II, Si II, Ca II, Ti II, Fe II), and broad coreless He I lines. Some of the sn stars seem to be related to CP stars. Initially Abt &amp; Levato proposed a shell-like nature to explain the sn stars, although this scenario was subsequently questioned. There is no general agreement about their origin. We aim to derive abundances for a sample of 9 stars, including sn and non-sn stars, to determine the possible relation between sn and CP stars and compare their chemical abundances. That most sn stars belong to open clusters allows us to search for a possible relation with fundamental parameters, including the age and rotation. We also study the possible contribution of different effects to the broad He I lines observed in these stars, such as Stark broadening and the possible He-stratification. Effective temperature and gravity were estimated by Strömgren photometry and then refined by requiring ionization and excitation equilibrium of Fe lines. We derived the abundances by fitting the observed spectra with synthetic spectra using an iterative procedure with the SYNTHE and ATLAS9 codes. We derived metallic abundances of 23 different chemical elements for 9 stars and obtained low projected rotational velocities for the sn stars in our sample (v sin i up to 69 km s-1). We also compared 5 stars that belong to the same cluster (NGC 6475) and show that the sn characteristics appear in the 3 stars with the lower rotational velocity. However, the apparent preference of sn stars for objects with the lower v sin i values should be taken with caution due to the small number of objects studied here. We analysed the photospheric chemical composition of sn stars and show that approximately 40% of them display chemical peculiarities (such as He-weak and HgMn stars) within a range of temperature of 10300 K-14500 K. However, there are also sn stars with solar or nearly-solar (i.e. non-CP) chemical composition. We have studied the possible contribution of different processes to the broad He I lines present in the sn stars. Although NLTE effects could not be completely ruled out, it seems that NLTE is not directly related to the broad He I profiles observed in the sn stars. The broad-line He I 4026 Å is the clearest example of the sn characteristics in our sample. We succesfully fit this line in 4 out of 7 sn stars by using the appropriate Stark broadening tables, while small differences appear in the other 3 stars. Studying the plots of abundance vs. depth for the He I lines resulted in some sn stars probably being stratified in He. However, a further study of variability in the He I lines would help for determining whether a possible non-uniform He superficial distribution could also play a role in these sn stars. We conclude that the broad He I lines that characterize the sn class could be modelled (at least in some of these stars) by the usual radiative transfer process with Stark broadening, without needing another broadening mechanism. The observed line broadening in sn stars seems to be related to the normal He line formation that originates in these atmospheres.                   ","palabras_clave":"STARS: CHEMICALLY PECULIAR|STARS: ABUNDANCES|STARS: LATE-TYPE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38057,"idioma_id":4,"titulo":"Modeling four and three-way fast high-performance liquid chromatography with fluorescence detection data for quantitation of fluoroquinolones in water samples","resumen":"tThis paper presents a study regarding the acquisition and analytical utilization of four and three-waydata, acquired by following the excitation?emission fluorescence matrices at different elution times, ina fast liquid chromatographic HPLC procedure. This kind of data were implemented for first time forquantitative purposes, and applied to the determination of two fluoroquinolones in tap water samples,as a model to show the potentiality of the proposed strategy of four-way data generation. The data weremodeled with three well-known algorithms: PARAFAC, U-PLS\/RTL and MCR-ALS, the latter convenientlyadapted to model third-order data. The second-order advantage was exploited when analyzing samplescontaining uncalibrated interferences. PARAFAC and MCR-ALS were the algorithms that better exploitedthe second-order advantage when no peak time shifts occurred among samples. On the other hand,when the quadrilinearity was lost due to the occurrence of temporal shifts, MCR-ALS furnished the betterresults. Relative error of prediction (REP%) obtained were 9.9% for ofloxacin and 14.0% for ciprofloxacin.In addition, a significant enhancement in the analytical figures of merit was observed when going fromsecond- to third-order data (reduction of ca. 70% in LODs).","palabras_clave":"HPLC|THIRD ORDER DATA|FLUOROQUINOLONES|WATER SAMPLES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38058,"idioma_id":4,"titulo":"Rational design of a culture medium for the intensification of lipid storage in 'Chlorella' sp. Performance evaluation in air-lift bioreactor","resumen":"An optimal medium to culture Chlorella sp., microalgae capable of storage intracellular   lipids was obtained. This culture medium consists of a saline base plus carbon-energy and   nitrogen sources. Significant factors exerting influence on the culture parameters were   selected. Then, by applying response surface methodology coupled to desirability function,   an optimal formulation, specific for the heterotrophic growth of Chlorella sp. that allows   maximizing lipid concentration was obtained. During the experimental verification, the   possibility of replacing commercial glucose by hydrolysates obtained from lignocellulosic   materials was evaluated. Biochemical hydrolysate of corn bran allowed obtaining important   improvements in lipid concentration. Finally, the optimal formulation was evaluated in an   air-lift bioreactor performing a fed-batch culture. Culturing the strain in these conditions   allowed rising lipid concentrations.","palabras_clave":"CHLORELLA|AIR-LIFT BIORRECACTOR|SCALE UP |LIGNOCELLULOSIC MATERIAL HYDROLYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38059,"idioma_id":5,"titulo":"Migración, fronteras y desplazamientos en la ciudad. Dinámicas de la alteridad urbana en Buenos Aires","resumen":"A partir del análisis de la experiencia urbana de migrantes bolivianos en la ciudad de Buenos Aires, el artículo problematiza los modos habituales de pensar las relaciones entre territorio, diferencia y desigualdad: el gueto racial y la periferia pobre.  En el artículo se resalta la imposibilidad de comprender estos procesos en clave unidimensional, enfatizando la relevancia de las intersecciones de clase, nacionalidad, género y 'raza' en la estructuración y uso del espacio urbano. Para esto, se analiza no sólo la posición y localización geográfica de los migrantes sino también sus lógicas de circulación y sus interacciones sociales en el espacio de la ciudad, en el que se reproducen y también se cuestionan las fronteras que estructuran la vida urbana.","palabras_clave":"MIGRACION|CIUDAD|DESPLAZAMIENTOS|SEGREGACION|INTERSECCIONES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38060,"idioma_id":4,"titulo":"The Application of K Phosphites to Seed Tubers Enhanced Emergence, Early Growth and Mycorrhizal Colonization in Potato (Solanum tuberosum)","resumen":"Rapid emergence and a vigorous growth prevent the seed tubers from infections by soil microbes and allow a rapid interception of solar radiation. In this work, the effect of the potassium phosphites (KPhi) applied to seed tubers of two potato cultivars on crop emergence and early growth was studied. Two experiments were per-formed under greenhouse and field conditions. Emergence of plants, leaf area, dry matter and the number of primary stems were measured in both experiments. Furthermore, mycorrhizal colonization was also measured on roots under field conditions. The application of KPhi reduced the period between planting and emergence, and increased leaf area and dry matter. The ratio between dry matter of aerials and underground organs was not affected by KPhi. Indigenous mycorrhizal colonization increased after KPhi application to seed tubers. These results confirm the benefit of the application of KPhi to seed tubers on early plant growth and suggest that their application in crop production would be advantageous. ","palabras_clave":"SEED TUBERS|LEAF AREA|DRY MATTER|CULTIVAR KENNEBEC|CULTIVAR SHEPODY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38061,"idioma_id":4,"titulo":"A BET approach to multilayer adsorption in swelling products","resumen":"An equation for multimolecular sorption is presented. it is based of the BET model with the assumption that the adsorbing surface can be divided in two regions:A region that supports only a limited number of adsorbed layers due to geometric restrictions, and another region that can adsorb an unlimited number of layers. The proposed equation is applicable to type 2 and 3 isotherms (BDDT classification), and was successfully used to fit water sorption equilibrium data of some foodstuff from literature for the water activity range 0.05-0.90, and a temperature range from 10 to 70 ºC.","palabras_clave":"adsorption|swelling |moisture|Porosity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38062,"idioma_id":4,"titulo":"Influence of the iron content on the arsenic adsorption capacity of Fe\/GAC adsorbents","resumen":"Adsorbents of granular activated carbon doped with iron (Fe\/GAC) were synthesized in the laboratory and their capacity for removal of arsenic species was measured by means of techniques of equilibrium adsorption and breakthrough curves. These data were obtained at room temperature and normal pH conditions. The materials were further characterized to determine their chemical composition and texture (specific surface, pore volume distribution). It was found that the adsorbents with 10%, 20% and 30% Fe had a great capacity for arsenic adsorption, showing uptake values of 2000?3500 mg of As per  gram of Fe\/GAC filter material. Doping with Fe increases the As adsorption capacity of granular activated carbon and the maximum capacity of adsorption is obtained with 10% Fe loading. Higher Fe contents decrease the capacity for arsenic removal. This was related to the decreased pore volume and pore size of the adsorbents with high Fe content. A decrease of surface accessibility due to pore plugging and a higher intraparticle diffusion resistance in the high loaded adsorbents would shift the point of bed breakthrough to lower values of eluted volume.","palabras_clave":"arsenic adsorption|groundwater|Fe\/GAC|arsenic remediation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38063,"idioma_id":4,"titulo":"PREDICTION OF HETEROTIC CROSSES FOR YIELD IN Pisum sativum L","resumen":"Efficient parent´s selection and heterosis prediction in pea have been of great interest for breeders inorder to determine with anticipation, those crosses capable of producing a high frequency of transgresive recombinant lines. The combining ability is the most frequently used criteria to select parents,though its estimation is costly and time-consuming. In this study we examine heterotic crosses for yield determined by morphological and molecular genetic distances between parents, and compare these with the heterotic crosses established by specific combing ability in a line × tester design. To select parental lines that would generate heterotic hybrids, different criteria were applied: genetic distances between lines obtained through morphological traits and molecular markers and cluster analysis. In spite genetic distances were more efficient than cluster analysis, the correlations values between them and heterosis were weak, and so, we propose to change the way to measure the importance of the genetic distances using the percentage of heterotic crosses that can be successfully predicted as parameter to evaluate. The percentage of heterotic crosses comparing best parent heterosis was higher than the one obtained com-paring midparent heterosis. SRAP methodology based on Dice distance between the parental lines and the Euclidean distances based in morphological data collection are the best alternative to SCA grouping association, since 69% and 65% of heterotic crosses can be predicted.","palabras_clave":"Pea|Heterosis|Combining ability|Genetic distances"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38064,"idioma_id":4,"titulo":"Bovine lactoferrin purification from whey using Yellow HE-4R as the chromatographic affinity ligand","resumen":"      The worldwide production of whey  increases by around 186 million tons each year and it is generally considered as a waste, even  when several whey proteins have important economic relevance. For its valorization,  inexpensive ligands and integrated chromatography methods need to be developed for specific and  low-cost protein purification. Here, we  describe a novel affinity process with the dye Yellow  HE-4R immobilized on Sepharose for bovine lactoferrin purification. This approach based on a  low-cost ligand showed an efficient performance for the recovery and purification of  bovine lactoferrin directly from whey, with a yield of 71% and a purification factor of 61.      ","palabras_clave":"BOVINE LACTOFERRIN|DYE AFFINITY CHROMATOGRAPHY|SWEET WHEY|TRIAZINE DYES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38065,"idioma_id":4,"titulo":"Functional studies of p.R132C, p.R149C, p.M283V, p.E431K, and a novel c.652-2A>G mutations of the CYP21A2 gene.","resumen":"Congenital adrenal  hyperplasia (CAH) due to 21-hydroxylase deficiency is the most frequent inborn  error of metabolism, and accounts for 90?95% of CAH cases. In the present work,  we analyzed the functional consequence of four novel previously reported point CYP21A2  mutations -p.R132C, p.R149C, p.M283V, p.E431K- found in Argentinean  21-hydroxylase deficient patients. In addition, we report an acceptor splice  site novel point mutation, c.652-2A&gt;G, found in a classical patient in  compound heterozygosity with the rare p.R483Q mutation. We performed  bioinformatic and functional assays to evaluate the biological implication of  the novel mutation.           Our analyses revealed that  the residual enzymatic activity of the isolated mutants coding for CYP21A2  aminoacidic substitutions was reduced to a lesser than 50% of the wild type  with both progesterone and 17-OH progesterone as substrates. Accordingly, all the  variants would predict mild non-classical alleles. In one non-classical  patient, the p.E431K mutation was found in cis with the p.D322G one. The  highest decrease in enzyme activity was obtained when both mutations were  assayed in the same construction, with a residual activity most likely related  to the simple virilizing form of the disease. For the c.652-2A&gt;G mutation,  bioinformatic tools predicted the putative use of two different cryptic  splicing sites. Nevertheless, functional analyses revealed the use of only one  cryptic splice acceptor site located within exon 6, leading to the appearance  of an mRNA with a 16 nt deletion. A severe allele is strongly suggested due to  the presence of a premature stop codon in the protein only 12 nt downstream.","palabras_clave":"CYP21A2 GENE|21-HYDROXYLASE|MUTATIONS|ADRENAL HYPERPLASIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38066,"idioma_id":4,"titulo":"Protective role of extracellular catalase (KatA) against UVA radiation in Pseudomonas aeruginosa biofilms","resumen":"One of the more stressful factors that Pseudomonas aeruginosa must face in nature is solar UVA radiation. In this study, the protective role of KatA catalase in both planktonic cells and biofilms of P. aeruginosa against UVA radiation was determined by using the wild-type (PAO1) and an isogenic catalase deficient strain (katA). The katA strain was more sensitive than the wild-type, especially in the case of biofilms. Moreover, the wild-type biofilm was more resistant than its planktonic counterpart, but this was not observed in the katA strain. Striking KatA activity was detected in the matrix of katA+ strains, and to our knowledge, this is the first report of this activity in the matrix of P. aeruginosa biofilms. Provision of bovine catalase or KatA to the matrix of a katA biofilm significantly increased its UVA tolerance, demonstrating that extracellular KatA is essential to optimal defense against UVA in P. aeruginosa biofilms. Efficiency of photocatalytic treatments using TiO2 and UVA was lower in biofilms than in planktonic cells, but KatA and KatB catalases seem not to be responsible for the higher resistance of the sessile cells to this treatment.","palabras_clave":"Pseudomonas|Biofilms|Ultraviolet-A|UVA|Catalase|KatA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38067,"idioma_id":4,"titulo":"Direct recoil spectroscopy of adsorbed atoms and self-assembled monolayers on Cu(001)","resumen":"We present results of adsorption experiments of Sn and 1,4-benzenedimethanethiol (BDMT) on Cu(001), which illustrate the capabilities of a new setup specifically designed to perform surface studies by Direct Recoil Spectroscopy (DRS). The system consists of three UHV chambers connected in series with a 1?100 keV ion accelerator. In the main UHV chamber the DRS technique is combined with other more standard techniques such as Auger and Energy Loss Electron Spectroscopy, and Low Energy Electron Diffraction. The capabilities of the instrument are exemplified by two adsorption studies on the (001) face of Cu. First we describe measurements for 0.5 monolayer of Sn adsorbed on Cu that are in agreement with the crystallographic symmetry (3sqrt(2) x sqrt(2))R45° seen by LEED and the appearance of Cu vacancies along the [100] direction. Then we present a study of self-assembling of 1,4-benzenedimethanethiol (BDMT) on Cu(001) from the vapour phase. For this system we show that it is possible to form a standing-up phase at large exposures, of the order of 106 L, and discuss its stability with temperature. We also discuss a S enrichment effect induced during the first adsorption stages of BDMT.","palabras_clave":"."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38068,"idioma_id":4,"titulo":"Oxygen vacancy induced local ferromagnetism as a driving mechanism in enhancing the magnetic response of ferrites","resumen":"This work probes the relevance of oxygen vacancies in the formation of local ferromagnetic coupling between  Fe ions at octahedral sites in zinc ferrites. This coupling gives rise to a ferrimagnetic ordering with the Curie  temperatures above room temperature in an otherwise antiferromagnetic compound. This conclusion is based on  experimental results from x-raymagnetic circular dichroismmeasurements at the Fe L2,3 edges and magnetization  measurements performed on zinc ferrites, nanoparticles, and films, with different cation distributions and oxygen  vacancy concentrations. Our observations are confirmed by density-functional-theory calculations and indicate  that the enhanced ferrimagnetic response observed in some nominally nonmagnetic or antiferromagnetic ferrites  can be taken as a further example of the defect-induced magnetism phenomenon.","palabras_clave":"MAGNETISM|FERRITES|VACANCIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38069,"idioma_id":4,"titulo":"Numerical and experimental stress analysis of an internal combustion engine valve during the closing event","resumen":"Valve engine manufacturers have to satisfy the market demands that require to increase the strength of their products and to extend the time between servicing. One of the main causes of failure in internal combustion engine valves is related to the high mechanical stresses generated during the valve closing event by loads resulting from a combination of factors like the return spring, the inertia loads of retainer, keeper and stem, the closing velocity, the valve tilt and the thermal loads induced by the combustion. The dynamics of the stress response during the closing event can be simulated numerically with transient dynamics models, by using the finite element method.   The objective of this work is to develop models to reproduce the valve closing process, to be able to predict numerically the maximum stress in new valve designs in a shorter time and at lower costs compared to experimental procedures, and to identify the main factors that contribute to valve stresses. The structural dynamics problem of the valve closing event was solved by using both the Newmark time integration algorithm and the generalized alpha method. The valve stem stress response under impact velocity was registered experimentally by using strain gauges and then compared with the finite element method solutions, showing good agreement.","palabras_clave":"valve close|finite element method|strain gauges|impact stress"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38070,"idioma_id":4,"titulo":"STANDARDIZED  FLOW  CYTOMETRY  ASSAY  FOR  IDENTIFICATION  OF HUMAN  MONOCYTIC  HETEROGENEITY  AND  LRP1  EXPRESSION  IN MONOCYTE  SUBPOPULATIONS:  DECREASED  EXPRESSION  OF  THIS RECEPTOR  IN  NON  CLASSICAL  MONOCYTES.","resumen":"We present a flow cytometry assay by which human blood monocyte subpopulations -classical (CD14++CD16-), intermediate (CD14++CD16+) and nonclassical (CD14+CD16++) monocytes - can be determined. Monocytic cells were selected from CD45+ leukocyte subsets by differential staining of LRP1, which allows reducing the spill-over of natural killer cells and granulocytes into the CD16+ monocyte gate. Percentages of monocyte subpopulations established by this procedure were significantly comparable to those obtained by a well standardized flow cytometry assay based on the HLA-DR monocyte-gating strategy. We also demonstrated that low density lipoprotein receptor-related protein 1 (LRP1) is differentially expressed at cell surface of monocyte subpopulations, being significantly lower in nonclassical monocytes than in classical and intermediate monocytes. Cell surface expression of LRP1 accounts for only 20% of the total cellular content in each monocyte subpopulation. Finally, we established the within-individual biological variation (bCV%) of circulating monocyte subpopulations in healthy donors, obtaining values of 21%, 20%, and 17% for nonclassical, intermediate and classical monocytes, respectively. Similar values of bCV% for LRP1 measured in each monocyte subpopulation were also obtained, suggesting that its variability is mainly influenced by the intrinsic biological variation of circulating monocytes. Thus, we conclude that LRP1 can be used as a third pan-monocytic marker together with CD14 and CD16 to properly identify monocyte subpopulations. The combined determination of monocyte subpopulations and LRP1 monocytic expression may be relevant for clinical studies of inflammatory processes, with special interest in atherosclerosis and cardiovascular disease.","palabras_clave":"monocyte heterogeneity|inflammation|biological variation|atherosclerosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38071,"idioma_id":4,"titulo":"Somatic embryogenesis from in vitro anther culture of apomictic buffel grass genotypes and analysis of regenerated plants using flow cytometry","resumen":"Buffel grass is a fodder grass that reproduces mainly via apomixis. Using in vitro tissue culture in apomictic species provides alternatives that can be applied in a breeding program. The aims of this work were to establish a protocol for in vitro generation of apomictic buffel grass genotypes using anthers as explants and to evaluate the genetic stability of regenerated plants via flow cytometry (FCM). Three genotypes were able to induce embryogenic calli in Murashige and Skoog (MS) medium supplemented with 6 mg\/l of 2,4-dichlorophenoxyacetic acid. Seedling regeneration occurred in a MS medium supplemented with 0.5 mg\/l napthaleneacetic acid ? 1 mg\/l 6-benzylaminopurin. Seedlings were derived from somatic embryos and the morphogenic process was induced using the somatic tissue of the stamens. Induction and regeneration efficiency depended on the genotype and was affected by date of tiller collection, different pretreatments or the interaction of these variables. FCM analyses in in vitro regenerated plants showed genetic instability in their nuclear DNA content.  Plants with lower nuclear DNA content may indicate DNA aneuploids (8.6 %), whereas plants that had twice the value of nuclear DNA content (4.7 %) suggest in vitro polyploidization. This variation observed in apomictic genotypes provides an opportunity to obtain new variants, which may then be included as sources of genetic variability in buffel grass breeding programs.","palabras_clave":"Apomixis |Nuclear DNA content |Somatic embryo|Plant breeding |Somaclonal variation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38072,"idioma_id":4,"titulo":"Occurrence and bioaccumulation of pharmaceuticals in a fish species inhabiting the Suquía River basin (Córdoba, Argentina)","resumen":"In SouthAmerica, there is a lack of data concerning the occurrence and levels of pharmaceuticals inmain rivers as well as their negative effects on the biota. Here we report the occurrence as well as the spatial and temporal variations of some common prescribed pharmaceuticals in the Suquía River basin (Córdoba, Argentina). We also report the bioconcentration of two of them in Gambusia affinis, a widely distributed fish species inhabiting the river basin. The influence of the wastewater treatment plant of Córdoba Citywas critical (up to 70 km downstream). Among 15 compounds analyzed, atenolol, carbamazepine and diclofenac were the most frequently detected (reaching sub &#956;g L&#8722;1 levels), showing different distribution patterns. Bioconcentration of atenolol and carbamazepine was studied under laboratory controlled conditions. Estimated bioconcentration factors (BCFs) were: 0.13 and 0.08 L kg&#8722;1 upon exposure to 100 and 1000 &#956;g L&#8722;1 atenolol in water, respectively; while BCFs were 0.7 and 0.9 L kg&#8722;1 when exposed to 10 and 100 &#956;g L&#8722;1 carbamazepine, respectively. To the extent of our knowledge, this is the first report on pharmaceuticals in superficial waters of Argentina as well as the firstreport on the bioaccumulation of atenolol in whole body fish.","palabras_clave":"Pharmaceuticals|South America|Gambusia affinis|Carbamazepine|Atenolol|Bioconcentration"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38073,"idioma_id":4,"titulo":"Anxiety, anger, salivary cortisol and cardiac autonomic activity in palliative care professionals with and without mind-body training experience: results from a pilot study.","resumen":"Introduction  Palliative care practitioners suffer a considerable burden of stress. Although it is not possible to eliminate stress entirely, people can learn to manage it. Mind\/body intervention helps individuals turn maladaptive responses to stress into more adaptive ones. The aim of the study was to assess the impact of mind?body techniques in a group of palliative care professionals.    Methods  We investigated anxiety, anger, baseline salivary cortisol levels immediately after awakening and autonomic nervous system activity in a group of health care professionals from a Palliative Care Unit (n = 22). In addition, we assessed the autonomic response to relaxation instructions. The participants were divided into two groups according to their regular practice of mind?body techniques.    Results  No significant differences between groups were found for anxiety and anger. Baseline salivary cortisol levels were significantly greater in the untrained group (5.23 ± 5.16 &#956;g\/dl) when compared with the trained one (0.57 ± 0.19 &#956;g\/dl) (Mann?Whitney U test = 0; p < 0.001). When comparing heart rate variability (HRV) values during relaxation with HRV values at rest within each group, trained subjects showed a significant increase in LF% (z = &#8722;2.073, p = 0.038), while untrained subjects showed a significant increase in HF% (z = &#8722;2.100, p = 0.036).    Conclusions  Subjects who regularly practice mind?body techniques evidenced lower baseline morning cortisol levels and achieved a differential autonomic response to relaxation instructions.","palabras_clave":"STRESS|CORTISOL|HEALTH PROMOTION|PALLIATIVE CARE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38074,"idioma_id":4,"titulo":"Simulation of CO Preferential Oxidation (COPrOx) Monolithic Reactors","resumen":"In this work, a COPrOx monolithic reactor with  a CuO\/CeO2  \/Al2O3 catalytic washcoat was modelled to  purify a H2 stream for a 2 kW PEM fuel cell. Preliminary  simulations included isothermal monoliths operating  between 423 and 463 K, and the optimization of linear  axial temperature profiles. For a fixed total system size  and a desired CO outlet molar fraction lower than 20  ppm, an isothermal temperature profile maximized the  global selectivity towards CO oxidation. Then, different  schemes of adiabatic monoliths with interstage cooling  were modelled and evaluated. It was found that wide  operating temperature ranges lower the necessary number of stages, but decrease the global selectivity and rise  system sensitivity to inlet temperatures. A 1D heterogeneous model was used to simulate the monoliths.","palabras_clave":"MONOLITHIC REACTORS|MODELLING|COPROX|PEM FUEL CELL|HEAT EXCHANGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38075,"idioma_id":4,"titulo":"Modelling Search Engines Performance using Coloured Petri Nets","resumen":"This paper proposes using Coloured Petri Nets to model performance of vertical searchengines forWeb search. In such systems, queries submitted by users or client systems are handled bydifferent components implemented as services deployed on large clusters of dedicated processors.We proposemodels that represent key features of components running time cost at a suitable level ofdetail. A comprehensive evaluation study is presented to reveal good precision of models when compared against actual implementations and complex process-oriented simulators of the same search engine instances. A C++ class library is proposed to enable rapid model construction by using a hierarchical and scalable approach, and to enable transparent generation and efficient execution ofrespective simulation programs either sequentially or in parallel.","palabras_clave":"Simulacion|Motores de Busqueda Web"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38076,"idioma_id":4,"titulo":"UML Profile for Mining Process: Supporting Modeling and Simulation based on Metamodels of Activity Diagram","resumen":"An UML profile describes lightweight extension mechanism to the UML by defining custom stereotypes, tagged values, and constraints. They are used to adapt UML metamodel to different platforms and domains. In this paper we present an UML profile for models supporting event driving simulation. In particular, we use the Arena simulation tool and we focus on the mining process domain. Profiles provide an easy way to obtain well-defined specifications, regulated by the Object Management Group (OMG). They can be used as a presimulation technique to obtain solid models for the mining industry. In this work we present a new profile to extend the UML metamodel; in particular we focus on the activity diagram. This extended model is applied to an industry problem involving loading and transportation of minerals in the field of mining process.","palabras_clave":"UML|PROFILE|METAMODEL|MINING PROCESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38077,"idioma_id":4,"titulo":"Cold storage of liver microorgans in ViaSpan and BG35 solutions: study of ammonia metabolism during normothermic reoxygenation","resumen":"Introduction. This work focuses on ammonia metabolism of Liver Microorgans (LMOs) after cold preserva- tion in a normothermic reoxygenation system (NRS). We have previously reported the development of a no- vel preservation solution, Bes-Gluconate-PEG 35 kDa (BG35) that showed the same efficacy as ViaSpan® to protect LMOs against cold preservation injury. The objective of this work was to study mRNA levels and activities of two key Urea Cycle enzymes, Carbamyl Phosphate Synthetase I (CPSI) and Ornithine Transcar- bamylase (OTC), after preservation of LMOs in BG35 and ViaSpan® and the ability of these tissue slices to detoxify an ammonia overload in a NRS model. Material and methods. After 48 h of cold storage (0°C in BG35 or ViaSpan®) LMOs were rewarmed in KHR containing an ammonium chloride overload (1 mM). We de- termined ammonium detoxification capacity (ADC), urea synthesis and enzyme activities and relative mRNA levels for CPSI and OTC. Results. At the end of reoxygenation LMOs cold preserved in BG35 have ADC and urea synthesis similar to controls. ViaSpan® group demonstrated a lower capacity to detoxify ammonia and to synthesize urea than fresh LMOs during the whole reoxygenation period which correlated with the lower mRNA levels and activities for CPSI and OTC observed for this group. Conclusion. We demonstrate that our preservation conditions (48 hours, BG35 solution, anoxia, 0oC) did not affect ammonia metabolism of cold preserved LMOs maintaining the physiological and biochemical liver functions tested, which allows their future use as biological component of a BAL system.","palabras_clave":"AMMONIA METABOLISM|LIVER MICROORGANS|COLD PRESERVATION|BG35"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38078,"idioma_id":5,"titulo":"Creatividad en la infancia: su relación con el desarrollo social","resumen":"El propósito de esta investigación es explorar variables del desarrollo infantil vinculadas a la creatividad y al desarrollo social en un grupo de 237 alumnos de 8 a 14 años de escuelas estatales de gestión pública de contextos de vulnerabilidad social. Los resultados señalaron la existencia de relaciones significativas entre los indicadores de creatividad y una serie de los indicadores sociométricos y de la dinámica relacional del aula. Aquellos niños que obtuvieron puntajes más elevados en los indicadores de creatividad, también&nbsp; fueron más elegidos por sus compañeros y obtuvieron un alto índice de liderazgo y de popularidad. Respecto de los indicadores de la dinámica relacional, se pudo comprobar una correlación negativa entre estos y los indicadores de creatividad.     La revista está Indexada en LATINDEX - IRESIE - DOAJ -CSIC     El artículo está disponible en:http:\/\/www.rieoei.org\/deloslectores\/5672Cymlich.pdf","palabras_clave":"CREATIVIDAD GRÁFICA|ESTATUS SOCIAL|INFANCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38079,"idioma_id":4,"titulo":"Non-covalent interactions in receptor-ligand complexes. A study based on the electron charge density","resumen":"In  this paper we reported the results obtained by charge density analysis of the  network of non covalent interactions established in the binding pocket of a  receptor, in relevant conformations of ligand - receptor complexes. Starting  with strong and moderate hydrogen bonds, moving on to weaker polar interactions  and ending with stacking and T-shape like interactions between aromatic rings,  all of them have been investigated within the  framework of the density functional theory and the quantum theory of atoms in  molecules (QTAIM). Also, natural bond orbital analysis (NBO) was carried out,  in order to evaluate quantitatively the electronic population of the aromatic  rings. The analysis of our -case study- shows that the interactions of the  catechol OH groups of the ligand, in the different conformations of the  dopamine ? D2 receptor complex, determine the decrease or increase of the  electron density on the aromatic ring of dopamine. In turn, the electronic population  of the aromatic ring of dopamine defines its orientation within the binding  site and the type of interactions that it establishes with the aromatic rings  of the receptor. Although the approach used here was traditionally applied to  the study of non covalent interactions in small molecules complexes in gas  phase, we show through this work that this methodology is also a very powerful  tool for the study of biomolecular complexes, providing a very detailed  description of the binding event.             &nbsp;","palabras_clave":"DFT|D2-dopamine rceptor |QTAIM|stacking interactions"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38080,"idioma_id":6,"titulo":"LA RACIONALIDAD ACTUAL DE LOS DERECHOS HUMANOS: LO JURÍDICO, LAS CIENCIAS HUMANAS Y LA GUBERNAMENTALIDAD","resumen":"Le document suivant tente de réfléchir à comment les droits de  l´homme permettent d´établir la relation entre savoir et pouvoir sur les  deux l´objectivation du mâle et de la subjectivation de la même chose,  mais en mettant l´accent sur la relation des droits de l´homme sur le rôle  du gouvernement : le comportement au volant de la population. Il est  considéré comme une référence pour tenir compte de ce que Foucault  développé par Miche cours de Collège de France entre 1975 et 1978, et ses  dernières interventions politiques de 1982 et 1983 en matière de droits de  la régie.  Les droits humains sont un mécanisme qui est parce qu´il intègre  universalistes de les aspects de la vie, le travail et la langue, et sont  mercantiliste car ils reçoivent les impacts d´une vérité que le marché,  avec sa logique de l´accumulation et la production tout inoculé touches.  Il est aussi juridique, car elle détermine la condition des êtres humains,  alors que personne, communauté ou minorité, et que de nouveaux types et  classifications à considérer. Les sciences humaines ont enrichi espaces,  ont oxygéné les relations de pouvoir disciplinaire, l´oppression, la  surveillance, la médicalisation, l´éducation, l´environnement, les  politiques en général. Droits de l´homme, pour leur part, ont travaillé  d´une manière coercitive envers le savoir pénitentiaire, médicale et  juridique.","palabras_clave":"Droits de l'homme|la discipline|biopolitique|Sciences humaines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38081,"idioma_id":4,"titulo":"Trace class operators, regulators, and assembly maps in K-theory","resumen":"&nbsp;Let $G$ be a group and let $KH$ be homotopy algebraic $K$-theory. We prove that if $G$ satisfies the rational $KH$ isomorphism conjecture for the group algebra $L^1[G]$ with coefficients in the algebra of trace-class operators in Hilbert space, then it also satisfies the $K$-theoretic Novikov conjecture for the group algebra over the integers, and the rational injectivity part of the Farrell-Jones conjecture with coefficients in any number field.","palabras_clave":"Borel regulator|Homotopy algebraic K-theory|Multiplicative K-theory|Trace class operators."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38082,"idioma_id":4,"titulo":"Electrochemical synthesis of palladium nanoparticles in PVP solutions and their catalytic activity in Suzuki and Heck reactions in aqueous medium","resumen":"Small palladium nanoparticles  (PdNPs) with large-surface area were synthesized in aqueous media in the presence  of poly(N-vinylpyrrolidone) (PVP) using a simple electrochemical method.  Electroreduction of Pd(II) species on a vitreous carbon electrode was performed  by application of a current density pulse and the resulting PVP?Pd dispersion  was formed. Highly concentrated PdNPs suspensions, stabilized with PVP  molecules were obtained in a short time at room temperature. The size and  morphology of the nanostructures obtained depend on the current density (30 to  8 nm PdNPs, for current densities in the _100 and _350 mA cm_2 range).  Nanoparticle structures with large-surface area were investigated by transmission  electron microscopy. The surface area of the PdNPs notably increased when the  current density is more negative. The resulting PVP-stabilized PdNPs showed a  very high catalytic activity when they were used in Suzuki and Heck reactions.  With elevated TON and TOF, and in aqueous medium, this catalytic system proved  to be an environmental friendly alternative to the conventional Pd catalyst.","palabras_clave":"HECK|SUZUKI|PALADIO|NANOPARTICULAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38083,"idioma_id":4,"titulo":"Quasi-static magnetic measurements to predict specific absorption rates in magnetic fluid hyperthermia experiments","resumen":"In this work, the issue on whether dynamic magnetic properties of polydispersed magnetic colloids modeled using physical magnitudes derived from quasi-static magnetic measurement can be extrapolated to analyze specific absorption rate data acquired at high amplitudes and frequencies of excitation fields is addressed. To this end, we have analyzed two colloids of magnetite nanoparticles coated with oleic acid and chitosan in water displaying, under a radiofrequency field, high and low specific heat power release. Both colloids are alike in terms of liquid carrier, surfactant and magnetic phase composition but differ on the nanoparticle structuring. The colloid displaying low specific dissipation consists of spaced magnetic nanoparticles of mean size around 4.8&#8201;nm inside a large chitosan particle of 52.5&#8201;nm. The one displaying high specific dissipation consists of clusters of magnetic nanoparticles of mean size around 9.7&#8201;nm inside a chitosan particle of 48.6&#8201;nm. The experimental evaluation of Néel and Brown relaxation times (&#8764;10&#8722;10&#8201;s and 10&#8722;4&#8201;s, respectively) indicate that the nanoparticles in both colloids magnetically relax by Néel mechanism. The isothermal magnetization curves analysis for this mechanism show that the magnetic nanoparticles behave in the interacting superparamagnetic regime. The specific absorption rates were determined calorimetrically at 260&#8201;kHz and up to 52&#8201;kA\/m and were well modeled within linear response theory using the anisotropy density energy retrieved from quasi-static magnetic measurement, validating their use to predict heating ability of a given polydispersed particle suspension. Our findings provide new insight in the validity of quasi-static magnetic characterization to analyze the high frequency behavior of polydispersed colloids within the framework of the linear response and Wohlfarth theories and indicate that dipolar interactions play a key role being their strength larger for the colloid displaying higher dissipation, i.e., improving the heating efficiency of the nanoparticles for magnetic fluid hyperthermia.","palabras_clave":"COLLOIDAL SYSTEMS|NANOPARTICLES|SUSPENSIONS|ACIDS|HYDRODINAMICS|POLYMERS|TRANSMITION ELECTRON MICROSCOPY|MAGNETIC NANOPARTICLES|MAGNETIC ANISOTROPY|RELAXATION TIMES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38084,"idioma_id":4,"titulo":"Involvement of dopamine signaling in the circadian modulation of interval timing","resumen":"Duration discrimination within the seconds-to-minutes range, known as interval timing, involves the interaction of cortico-striatal circuits via dopaminergic-glutamatergic pathways. Besides interval timing, most (if not all) organisms exhibit circadian rhythms in physiological, metabolic and behavioral functions with periods close to 24&#8197;h. We have previously reported that both circadian disruption and desynchronization impaired interval timing in mice. In this work we studied the involvement of dopamine (DA) signaling in the interaction between circadian and interval timing. We report that daily injections of levodopa improved timing performance in the peak-interval procedure in C57BL\/6 mice with circadian disruptions, suggesting that a daily increase of DA is necessary for an accurate performance in the timing task. Moreover, striatal DA levels measured by reverse-phase high-pressure liquid chromatography indicated a daily rhythm under light\/dark conditions. This daily variation was affected by inducing circadian disruption under constant light (LL). We also demonstrated a daily oscillation in tyrosine hydroxylase levels, DA turnover (3,4-dihydroxyphenylacetic acid\/DA levels), and both mRNA and protein levels of the circadian component Period2 (Per2) in the striatum and substantia nigra, two brain areas relevant for interval timing. None of these oscillations persisted under LL conditions. We suggest that the lack of DA rhythmicity in the striatum under LL - probably regulated by Per2 - could be responsible for impaired performance in the timing task. Our findings add further support to the notion that circadian and interval timing share some common processes, interacting at the level of the dopaminergic system.","palabras_clave":"circadian system|interval timing|dopamine|time perception"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38085,"idioma_id":4,"titulo":"A comparative study on phosphotransferase activity of acid phosphatases from Raoultella planticola and Enterobacter aerogenes on nucleosides, sugars and related compounds","resumen":"Natural and modified nucleoside-5&#8242;-monophosphates and their precursors are valuable compounds widely used in biochemical studies. Bacterial nonspecific acid phosphatases (NSAPs) are a group of enzymes involved in the hydrolysis of phosphoester bonds, and some of them exhibit phosphotransferase activity. NSAP containing Enterobacter aerogenes and Raoultella planticola whole cells were evaluated in the phosphorylation of a wide range of nucleosides and nucleoside precursors using pyrophosphate as phosphate donor. To increase the productivity of the process, we developed two genetically modified strains of Escherichia coli which overexpressed NSAPs of E. aerogenes and R. planticola. These new recombinant microorganisms (E. coli BL21 pET22b-phoEa and E. coli BL21 pET22b-phoRp) showed higher activity than the corresponding wild-type strains. Reductions in the reaction times from 21 h to 60 min, from 4 h to 15 min, and from 24 h to 40 min in cases of dihydroxyacetone, inosine, and fludarabine, respectively, were obtained.","palabras_clave":"nucleoside-5&#8242;-monophosphates |Bacterial nonspecific acid phosphatases |Biotransformations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38086,"idioma_id":4,"titulo":"Searching for star-forming dwarf galaxies in the Antlia cluster","resumen":"Context. The formation and evolution of dwarf galaxies in clusters need to be understood, and this requires large aperture telescopes.         Aims. In this sense, we selected the Antlia cluster to continue our previous work in the Virgo, Fornax, and Hydra clusters and in the Local Volume (LV). Because of the scarce available literature data, we selected a small sample of five blue compact dwarf (BCD) candidates in Antlia for observation.         Methods. Using the Gemini South and GMOS camera, we acquired the H&#945; imaging needed to detect star-forming regions in this sample. With the long-slit spectroscopic data of the brightest seven knots detected in three BCD candidates, we derived their basic chemical properties. Using archival VISTA VHS survey images, we derived KS magnitudes and surface brightness profile fits for the whole sample to assess basic physical properties.         Results. FS90-98, FS90-106, and FS90-147 are confirmed as BCDs and cluster members, based on their morphology, KS surface photometry, oxygen abundance, and velocity redshift. FS90-155 and FS90-319 did not show any H&#945; emission, and they could not be confirmed as dwarf cluster star-forming galaxies. Based on our data, we studied some fundamental relations to compare star forming dwarfs (BCDs and dIs) in the LV and in the Virgo, Fornax, Hydra, and Antlia clusters.         Conclusions. Star-forming dwarfs in nearby clusters appear to follow same fundamental relations in the near infrared with similar objects in the LV, specifically the size-luminosity and the metallicity-luminosity, while other more fundamental relations could not be checked in Antlia due to lack of data. ","palabras_clave":"GALAXIES|STAR|FORMATION|ANTLIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38087,"idioma_id":4,"titulo":"THE SPATIAL STRUCTURE OF LITHIC LANDSCAPES: THE LATE HOLOCENE RECORD OF EAST-CENTRAL ARGENTINA AS A CASE STUDY","resumen":"The aim of this paper is to discuss conceptual and methodological issues related with the archaeological study of lithic landscapes, and exemplify the approach with a case study represented by artifact distribution data from east-central Argentina. A lithic landscape?understood as the co-occurrence, in a given geographic space, of different structural units composed by a raw material source and the complete set of unmodified and human-modified rocks extracted from that source (i.e. an scatter area)?can be modeled using kriging, a geostatistical interpolation tool useful to express the spatial variation in point process data through a number of continuous surface maps. The application of this approach to the analysis of the spatial distribution of three toolstone classes (relative frequency data) in the study area allows for the examination of (1) the relationship between, on one hand, the type and location of the sources and, on the other, the size and shape of the respective scatter areas, and (2) the reciprocal relationships between competing raw materials and sources. It is concluded that a proper description of the spatial structure of a lithic landscape is the needed baseline from which to evaluate different explicative models about their underlying generative mechanisms.","palabras_clave":"LITHIC LANDSCAPES|RAW MATERIAL SOURCES|ARTIFACT DISTRIBUTIONS|GEOSTATISTICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38088,"idioma_id":4,"titulo":"QSAR on antiproliferative naphthoquinones based on a conformation-independent approach","resumen":"The antiproliferative activities of a series of 36 naphthoquinone derivatives were subjected to a Quantitative Structure-Activity Relationships (QSAR) study. For this purpose a panel of four human cancer cell lines was used, namely HBL-100 (breast), HeLa (cervix), SW-1573 (non-small cell lung) and WiDr (colon). A conformation-independent representation of the chemical structure was established in order to avoid leading with the scarce experimental information on X-ray crystal structure of the drug interaction. The 1179 theoretical descriptors derived with E-Dragon and Recon software were simultaneously analyzed through linear regression models based on the Replacement Method variable subset selection technique. The established models were validated and tested through the use of external test sets of compounds, the Leave-One-Out Cross Validation method, Y-Randomization and Applicability Domain analysis","palabras_clave":"QSAR THEORY|MOLECULAR DESCRIPTORS|NAPHTOQUINONES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38089,"idioma_id":4,"titulo":"Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor","resumen":"Glucocorticoids are essential for life, but are also implicated in disease pathogenesis and may produce unwanted effects  when given in high doses. Glucocorticoid receptor (GR) transcriptional activity and clinical outcome have been linked to its  oligomerization state. Although a point mutation within the GR DNA-binding domain (GRdim mutant) has been reported as  crucial for receptor dimerization and DNA binding, this assumption has recently been challenged. Here we have analyzed  the GR oligomerization state in vivo using the number and brightness assay. Our results suggest a complete, reversible, and  DNA-independent ligand-induced model for GR dimerization. We demonstrate that the GRdim forms dimers in vivo whereas  adding another mutation in the ligand-binding domain (I634A) severely compromises homodimer formation. Contrary to  dogma, no correlation between the GR monomeric\/dimeric state and transcriptional activity was observed. Finally, the state  of dimerization affected DNA binding only to a subset of GR binding sites. These results have major implications on future  searches for therapeutic glucocorticoids with reduced side effects.","palabras_clave":"GLUCOCORTICOID RECEPTOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38090,"idioma_id":5,"titulo":"Modelo de simulación de producción de materia seca y concentración de proteína bruta de gramíneas creciendo en bosques de Nothofagus antarctica (G. Forster) Oerst. bajo uso silvopastoril","resumen":"RESUMEN. Nothofagus antarctica (ñire) ocupa una importante fracción de los bosques de la Patagonia Austral y suele ser usado en sistemas silvopastoriles. Se carece, sin embargo de información que permita hacer un uso óptimo y sustentable de estos sistemas. En este trabajo se modeló la producción de materia seca (MS) y la variación en la concentración de proteína bruta (PB) de gramíneas en sistemas silvopastoriles en bosques de ñire, considerando variables ambientales (temperaturas de aire y suelo, humedad de aire y suelo, calidad de sitio, cobertura de copas, entre otras) y aplicando información propia y existente. El modelo se focalizó a la escala de rodal; se consideró una población homogénea y coetánea de ñire bajo las condiciones del sur de laPatagonia (Santa Cruz y Tierra del Fuego). Un análisis de sensibilidad mostró que los parámetros más influyentes fueron la clase de sitio sobre MS y la temperatura del suelo sobre PB. Al comparar valores reales y simulados se encontró una correlación lineal significativa para MS (R=0.52; P&lt;0.001, subestimación media de 22%) y PB (R=0.47; P&lt;0.001, sobreestimación media de 24%). Los resultados de las simulaciones son coherentes con los antecedentes empíricos respecto al efecto del ambiente y el manejo del rodal sobre la MS y PB del sotobosque y sugieren que el modelo es aceptable para ser usado como una herramienta orientadora del manejo de lospastizales en bosques de ñire.","palabras_clave":"sistemas silvopastoriles en patagonia|bosque nativo|produccion|calidad de forraje"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38091,"idioma_id":4,"titulo":"The glycosylphosphatidylinositol-anchored protein repertoire of Babesia bovis and its significance for erythrocyte invasion","resumen":"Glycosylphosphatidylinositol-anchored proteins are abundant on the surface of pathogenic protozoans and might play an important role for parasite survival. In the present work, the relevance of GPIanchored  proteins for erythrocyte invasion of the cattle hemoparasite Babesia bovis was studied. We show that cleavage of GPI-anchored antigens from the merozoite parasite stage by phosphatidylinositol-specific phospholipase C abolished invasion of erythrocytes demonstrating the importance of this class of molecules for parasite propagation. In addition, the repertoire of GPI-anchored proteins of B. bovis was  predicted with high fidelity by searching its genome with available web-based bioinformatic tools. Altogether 17 GPI-anchored proteins were identified, 5 of which represent the already characterized variable  merozoite surface antigens (VMSAs). Fifteen of the identified GPI-anchored proteins contain 2\u201326 amino acid repeats indicating that they are likely involved in functions of recognition, adhesion, or transport.  Repeats were found to contain an increased frequency of proline,  indicative of unstructured regions; and were estimated to be 3.21 times more hydrophilic than non-repeat regions. This suggests that they might  represent eminent antibody epitopes. The majority of the putative GPI-anchored antigens reported in this work have so far remained unnoticed, though they may represent potential candidates for inclusion in a subunit vaccine.","palabras_clave":"Babesia bovis|Bovine babesiosis|Glycosylphosphatidylinositol|GPI-anchor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38092,"idioma_id":4,"titulo":"Application of a Mathematical Model for Production of Recombinant Antibody 14D9 by Nicotiana tabacum Cell Suspension Batch Culture","resumen":"                    One  of the bottlenecks in biopharming is the scalability and modeling of batch  cultures at bench scale, largely because  bioreactors and mathematical models were originally designed for microbe  cultures. Thus, a mathematical model that acknowledges kinetic and growth  processes, basic aspect of cell structure, and physiology and productivity is  needed. We proposed to apply a new combination of structured and unstructured  mathematical models for plant cell cultivation in a  bioreactor. The mathematical model is  based on the theory of energy-limited growth that allows precise evaluation of  a cell population age structure into the bioreactor. We have scaled the full antibody r14D9 expressed in N. tabacum cell suspension from a 225  mL-Erlenmeyer flask to 2L-bioreactor and applied the above mentioned  mathematical model in order to estimate and predict the growth rate of cell  cultures and the accumulation of the recombinant protein. Under the proposed  model two inoculum sizes were used in order to obtain  experimental data, specific growth rates and productivity, which allow the  analysis of the predictions under different conditions.    ","palabras_clave":"modelado matematico|molecular farming|bioprocesos|anticuerpos recombinantes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38093,"idioma_id":5,"titulo":"Organización reticular de la memoria semántica. Natural Finder y Definition Finder, dos métodos informatizados para recuperar conocimiento","resumen":"Dos líneas de teorías estudian la organización del conocimiento conceptual: las holísticas y las de rasgos. El objetivo de este trabajo es presentar dos métodos informatizados de captura y análisis de redes semánticas, el Natural Finder y el Definition Finder, que responden a estos modelos respectivamente. El primero es un procedimiento recursivo para capturar a partir de un concepto disparador la red semántica natural de una persona en torno a dicho concepto; el segundo permite obtener el conjunto de atributos ponderados que mejor definen a un concepto para un colectivo social. Se presentan ejemplos de su aplicación.","palabras_clave":"red semántica|definition finder|natural finder"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38094,"idioma_id":5,"titulo":"La sinonimia como caso particular de distancia semántica","resumen":"Los modelos de rasgos sugieren que la representación semántica se constituye a partir de una serie de atributos que describen un concepto. Existe acuerdo en que a mayor cantidad de atributos comunes entre dos conceptos aumenta la probabilidad de que pertenezcan a una misma categoría. La hipótesis que subyace a este trabajo es que el grado de sinonimia se constituye como un caso extremo de la mayor cantidad de atributos compartidos. De este modo se estableció la correspondencia entre la sinonimia tal como es presentada en Diccionarios y Tesauros y la sinonimia obtenida experimentalmente a partir de las distancias. Se utilizaron las Normas de Producción de Atributos Semánticos en Castellano obtenidas a partir de 800 jóvenes universitarios. Se obtuvieron las distancias semánticas para 39 palabras pertenecientes a las Normas y a los Diccionarios por medio del cálculo del coseno entre vectores en un espacio n-dimensional para determinar los grados de coincidencia o sinonimia. Los resultados sugieren que las distancias entre los pares considerados sinónimos por los Diccionarios resultó superior a 0.9 cuando pertenecen a una subcategoría específica. Para las palabras con una distancia próxima a 0.8 se advierte la pertenencia a una misma categoría de base y cuando la sinonimia se da por pertenecer a una misma categoría amplia puntuaron entre 0.6 y 0.8.","palabras_clave":"sinonimia|distancia semántica|atributos semánticos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38095,"idioma_id":5,"titulo":"Espacios fronterizos del sur sudamericano. Propuesta de un modelo conceptual para su  estudio","resumen":"Se presenta un modelo conceptual para abordar el estudio geográfico comparado de los espacios fronterizos formados entre estados nacionales. La sistematización empírica en la que se basa la propuesta se viene realizando en el ámbito del sur de sudamericano, entendiendo por tal al área donde se diferenciaron, a lo largo de los siglos XIX y XX, los territorios de seis estados nacionales: Argentina, Bolivia, Brasil, Chile, Paraguay y Uruguay. Este artículo apunta a renovar, desde la tradición geográfica crítica, los estudios sobre fronteras de la Argentina, a partir de una mirada relacional y multiescalar en la construcción de los territorios. El modelo aludido reconoce seis componentes principales para el estudio de los espacios fronterizos: diferenciación territorial, fronterización, territorios interiores, territorios exteriores, lugares de frontera y movilidades. Cada uno de estos componentes será presentado a partir de ejemplos tomados del área de estudio.","palabras_clave":"FRONTERA|ESPACIO FRONTERIZO|SUDAMERICA|LIMITE INTERNACIONAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38096,"idioma_id":4,"titulo":"A Positive Cooperativity Binding Model between Ly49 Natural Killer Cell Receptors and the Viral Immunoevasin m157. Kinetic and Thermodynamic Studies.","resumen":"Natural killer (NK) cells discriminate between healthy and virally infected or transformed cells using diverse surface receptors that are both activating and inhibitory. Among them, the homodimeric Ly49 NK receptors, which can adopt two distinct conformations (backfolded and extended), are of particular importance for detecting cells infected with mouse cytomegalovirus (CMV) via recognition of the viral immunoevasin m157. The interaction of m157 with activating (Ly49H) and inhibitory (Ly49I) receptors governs the spread of mouse CMV. We carried out kinetic and thermodynamic experiments to elucidate the Ly49\/m157 binding mechanism. Combining surface plasmon resonance, fluorescence anisotropy, and circular dichroism (CD), we determined that the best model to describe both the Ly49H\/m157 and Ly49I\/m157 interactions is a conformational selection mechanism where only the extended conformation of Ly49 (Ly49*) is able to bind the first m157 ligand followed by binding of the Ly49*\/m157 complex to the second m157. The interaction is characterized by strong positive cooperativity such that the second m157 binds the Ly49 homodimer with a 1000-fold higher sequential constant than the first m157 (10(8) versus 10(5) m(-1)). Using far-UV CD, we obtained evidence for a conformational change in Ly49 upon binding m157 that could explain the positive cooperativity. The rate-limiting step of the overall mechanism is a conformational transition in Ly49 from its backfolded to extended form. The global thermodynamic parameters from the initial state (backfolded Ly49 and m157) to the final state (Ly49*\/(m157)2) are characterized by an unfavorable enthalpy that is compensated by a favorable entropy, making the interaction spontaneous.","palabras_clave":"LY49 | INNATE IMMUNITY|SPR|NATURAL KILLER CELL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38097,"idioma_id":4,"titulo":"Biochemical characterization of Macrocystis pyrifera (Linnaeus) C.Agardh and Undaria pinnatifida (Harvey) Suringar  (Phaeophyceae)  in relation to their potentiality as biosorbents","resumen":"ABSTRACT: Undaria pinnatifida and Macrocystis pyrifera from Patagonia were characterized in terms of the alginate,protein, total carbohydrate and organic matter content, cation exchange capacity and acid-base properties to assess thesuitability of both species as potential biosorbents of metals. Environmental scanning electron microscopy equipped withan energy dispersive X-ray microanalysis system, Fourier transform infrared spectroscopy (FT-IR) and Brunauer,Emmett and Teller surface area analysis were also applied for characterization. The results showed that U. pinnatifida hada higher percentage of organic matter, alginate and protein and a larger specific surface area than M. pyrifera, althoughthe latter exhibited a higher ionic exchange capacity. The groups with a weak acid behaviour represented 84% and 97% ofthe total acid groups in M. pyrifera and U. pinnatifida, respectively. FT-IR analysis confirmed the presence of differentchemical groups such as sulphonate in both biomaterial M. pyrifera and U. pinnatifida. Besides, Zn(II) adsorptioncapacity was different among different parts of the thallus of each species. The difference founded in the physicochemicalproperties of both algae could affect their biosorption capacities.","palabras_clave":"BIOCHEMICAL CHARACTERIZATION|BIOSORPTION|MACROCYSTIS PYRIFERA|UNDARIA PINNATIFIDA|ZINC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38098,"idioma_id":4,"titulo":"Pectin extraction from quince (Cydonia oblonga) pomace applying alternative methods: effect of process variables and preliminary optimization","resumen":"                      The  objectives of this work were to introduce alternative methods in the process of  pectin extraction from quince pomace, to determine the effect of selected  process variables (factors) on the obtained pectin, and to perform a  preliminary optimization of the process. A fractional factorial experimental  design was applied, where the factors considered were six: quince pomace pre-treatment  (washing vs. blanching), drying method (hot air, HAD, vs. low pressure  superheated steam, LPSSD), acid extraction condictions (pH, temperature, time), and pectin extract  concentration method (vacuum evaporation vs ultrafiltration). The effects of these factors and  their interactions on pectin  yield (Y: 0.2 - 34.2 mg\/g), galacturonic acid content (GalA: 44.5 - 76.2  %), and degree of methylation (DM: 47.5 ? 90.9 %), were determined. For these  three responses, extraction pH was the main effect, but it was involved in two  and three factors interactions. Regarding alternative methods, LPSSD was  required for maximum Y and GalA, and ultrafiltration for maximum GalA and DM. Response models were used to predict optimum process conditions (quince  blanching, pomace drying by LPSSD, acid extraction at pH 2.20, 80 °C, 3 h, and  concentration under vacuum) to simultaneously maximize Y (25.2 mg\/g), GalA (66.3  %), and DM (66.4 %).  ","palabras_clave":"extraction systems|pectins|fruits|cell wall polysaccharides"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38099,"idioma_id":4,"titulo":"Protein intrinsic disorder and network connectivity. The case of 14-3-3 proteins","resumen":"The understanding of networks is a common goal of an unprecedented array of traditional disciplines. One of the protein network properties most influenced by the structural contents of its nodes is the inter-connectivity. Recent studies in which structural information was included into the topological analysis of protein networks revealed that the content of intrinsic disorder in the nodes could modulate the network topology, rewire networks, and change their inter-connectivity, which is defined by its clustering coefficient. Here, we review the role of intrinsic disorder present in the partners of the highly conserved 14-3-3 protein family on its interaction networks. The 14-3-3s are phospho-serine\/threonine binding proteins that have strong influence in the regulation of metabolism and signal transduction networks. Intrinsic disorder increases the clustering coefficients, namely the inter-connectivity of the nodes within each 14-3-3 paralog networks. We also review two new ideas to measure intrinsic disorder independently of the primary sequence of proteins, a thermodynamic model and a method that uses protein structures and their solvent environment. This new methods could be useful to explain unsolved questions about versatility and fixation of intrinsic disorder through evolution. The relation between the intrinsic disorder and network topologies could be an interesting model to investigate new implicitness of the graph theory into biology.","palabras_clave":"protein intrinsic disorder|protein interaction networks|14-3-3 protein family|post-translational modifications"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38100,"idioma_id":4,"titulo":"Amelioration of lipopolysaccharide induced acute kidney injury by erythropoietin: involvement of mitochondria regulated apoptosis","resumen":"Sepsis remains the most important cause of acute kidney injury (AKI) in critically ill patients and is an independent predictor of poor outcome. The administration of lipopolysaccharide (LPS) to animals reproduces most of the clinical features of sepsis, including AKI, a condition associated with renal cellular dysfunction and apoptosis. Erythropoietin (EPO) is a well known cytoprotective multifunctional hormone, which exerts anti-inflammatory, anti-oxidant, anti-apoptotic and angiogenic effects in several tissues. The aim of this study was to evaluate the underlying mechanisms of EPO renoprotection through the expression of the EPO receptor (EPO-R) and the modulation of the intrinsic apoptotic pathway in LPS-induced AKI. Male inbred Balb\/c mice were divided in four experimental groups: Control, LPS (8 mg\/kg i.p.), EPO (3000 IU sc) and LPS+EPO. Assessment of renal function, histological examination, TUNEL in situ assay, immunohistochemistry and Western blottings of caspase-3, Bax, Bcl-xL, EPO-R and Cytochrome c were performed at 24h post treatment. LPS+EPO treatment significantly improved renal function and ameliorated histopathological injury when compared to the LPS treated group. Results showed that EPO treatment attenuates renal tubular apoptosis through: (a) the overexpression of EPO-R in tubular interstitial cells, (b) the reduction of Bax\/Bcl-xL ratio, (c) the inhibition Cytochrome c release into the cytosol and (d) the decrease of the active caspase-3 expression. This study suggests that EPO exerts renoprotection on an experimental model of LPS-induced AKI. EPO induced renoprotection involves an anti-apoptotic effect through the expression of EPO-R and the regulation of the mitochondrial apoptotic pathway","palabras_clave":"LPS-induced AKI|Apoptosis|Erythropoietin|Renoprotection|Cytochrome c|EPO-R"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38101,"idioma_id":4,"titulo":"Micro-geographical scale variation in Drosophila melanogaster  larval olfactory behaviour is associated with host fruit heterogeneity","resumen":"Organisms utilize environmental cues to deal with heterogeneous environments. In this sense, behaviours that mediate interactions between organisms and their environment are complex traits, especially sensitive to environmental conditions. In animals, olfaction is a critical sensory system that allows them to acquire chemical information from the environment. The genetic basis and physiological mechanisms of the olfactory system of Drosophila melanogaster Meigen (Diptera: Drosophilidae) are well known, but the effects of ecological factors on the olfactory system have received less attention. In this study, we analysed the effect of environmental heterogeneity (different host fruits) on variation in larval olfactory behaviour in a natural population of D. melanogaster. We generated half-sib lines of D. melanogaster derived from two nearby fruit plantations, Vitis vinifera L. (Vitaceae) ('grape') and Prunus persica L. (Rosaceae) ('peach'), and measured, using a simple behavioural assay, larval olfactory response to natural olfactory stimuli. Results indicate that patterns of variation for this trait depend on host fruit plantation where lines were collected. In fact, only lines derived from 'grape' showed phenotypic plasticity for larval olfaction, whereas a genotype*environment interaction was detected solely in lines derived from 'peach'. Therefore, our results demonstrate the existence of genetic differences in D. melanogaster larval olfactory behaviour at a micro-geographical scale and also reveal that the trait studied presents a dynamic genetic architecture which is strongly influenced by the environment.","palabras_clave":"Natural variation|Phenotypic plasticity|Micro-geographical distances|Genotype by environment interaction|Diptera, |Drosophilidae"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38102,"idioma_id":4,"titulo":"G protein-coupled receptor30\/adenylyl cyclase\/protein kinase A pathway is involved in estradiol 17ß-D-glucuronide-induced cholestasis","resumen":"Estradiol-17ß-D-glucuronide (E17G) activates different signaling pathways (such ascPKC, PI3K-Akt, MAP kinases p38 and ERK1\/2 and estrogen receptor &#945;) that lead toacute cholestasis in rat liver with retrieval of the canalicular transporters bile salt exportpump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). E17G shares withnon-conjugated estradiol the capacity to activate these pathways. The G protein-coupledreceptor 30 (GPR30) is a receptor implicated in non-genomic effects of estradiol and theaim of this study was to analyze the potential role of this receptor and its down-streameffectors in E17G-induced cholestasis. In vitro, GPR30 inhibition by G15 or its knockdown with siRNA strongly prevented E17G-induced impairment of canaliculartransporters function and localization. E17G increased cAMP levels and this increase wasblocked by G15, linking GPR30 to adenylyl cyclase (AC). Moreover, AC inhibition totallyprevented E17G insult. E17G also increased PKA activity, which was blocked by G15 andAC inhibitors, connecting the links of the pathway GPR30-AC-PKA. PKA inhibitionprevented E17G-induced cholestasis, whereas Epac\/MEK, another cAMP downstreameffector, was not implicated in cAMP cholestatic action. In the perfused rat liver model,inhibition of GPR30-AC-PKA pathway totally prevented E17G-induced alteration inAbcb11 and Abcc2 function and localization. In conclusion, activation of GPR30-AC-PKAis a key factor in the alteration of canalicular transporters function and localization inducedby E17G. The interaction of E17G with GPR30 may be the first event in the cascade ofsignaling activation.","palabras_clave":"Transportadores canaliculares|Señalización intracelular|Estrógenos|Colestasis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38103,"idioma_id":4,"titulo":"Biopulping of wood chips with Phlebia brevispora BAFC 633 reduces lignin content and improves pulp quality","resumen":"The white-rot fungus Phlebia brevispora BAFC 633 produces laccases in large proportions. In this work P. brevispora BAFC 633 was grown on Pinus taeda wood chips in 10-L bioreactors. To select the biopulping experimental conditions, we analyzed the variables affecting enzymatic laccase activity in the culture supernatants, indicating that the suitable incubation temperature was 30 C in order to promote enzyme stability. Phlebia brevispora BAFC 633 secreted 744 U\/g of laccase, selectively removing lignin during biotreatment of wood chips, causing a reduction in Kappa number and 10% weight loss, and creating a more open structure and better access to the pulping liquor, which would require less chemical consumption, thus diminishing the environmental impact of the chemical pulping process.These results support the biotechnological potential of P. brevispora BAFC 633 for biopulping processes and enhance the potential for bioprospecting native isolates of the micro fl ora of our country?s natural environment.","palabras_clave":"PHLEBIA BREVISPORA BAFC 633|PINUS TAEDA|LACCASE|BIOPULPING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38104,"idioma_id":4,"titulo":"Studies on PVA Pectin cryogels containing crosslinked enzyme aggregates of keratinase","resumen":"          Polyvinyl  alcohol-pectin (PVA-P) films containing enrofloxacin and keratinase were developed  to treat wounds and scars produced by burns and skin injuries. However, in  order to prevent enzyme inactivation at the interface between the patch and the  scars, crosslinked enzyme aggregates (CLEAs) from a crude extract of keratinase  produced by Paecilomyces lilacinus(LPSC#876) were  synthesized by precipitation with acetone and crosslinking with glutaraldehyde.  Soluble vs. CLEA keratinase (K-CLEA) activities were tested in 59 % (v\/v) hydrophobic  (isobutanol and n-hexane) and hydrophilic (acetone and dimethylsulfoxide) solvents  mixtures. K-CLEA activity was 1.4, 1.7 and 6.6 times higher in acetone,  n-hexane and isobutanol than the soluble enzyme at 37 ºC after 1 h of  incubation, respectively. KCLEA showed at least 45 % of enzyme residual  activity in the 40 to 65ºC range, meanwhile the soluble biocatalyst was fully  inactivated at 65 ºC after 1 h incubation. Also, the soluble enzyme was  completely inactivated after 12 hours at pH 7.4 and 45 ºC, even though K-CLEA retained  full activity. The soluble keratinase was completely inactivated at 37 ºC after  storage in buffer solution (pH= 7.4) for two months, meanwhile K-CLEAs kept 51  % of their activity. K-CLEA loaded into polyvinyl alcohol (PVA) and PVA-P  cryogels showed six times lower release rate compared to the soluble keratinase  at skin pH (5.5). Small angle X-ray scattering (SAXS) analysis showed that  K-CLEA bound to pectin rather than to PVA in the PVA-P matrix.  ","palabras_clave":"CLEA|keratinase|controlled release|PVA|cryogel|autolysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38105,"idioma_id":5,"titulo":"INTERPRETACIÓN DE LAS PRINCIPALES ESTRUCTURAS DE LA PAYENIA APLICANDO EL MÉTODO POTENCIAL GRAVIMÉTRICO","resumen":"Por medio de la aplicación de los métodos potenciales se pudieron caracterizar los depocentros andinos del borde noroeste de la Cuenca Neuquina, situados en la provincia geológica de Payenia, facilitando el estudio de estructuras emplazadas a nivel cortical. Para ello se efectuaron mediciones gravimétricas apoyadas con diferencial GPS en modo posproceso para obtener las coordenadas de las estaciones (DGPS-700 estaciones), se recopilaron y controlaron más de 10000 valores de gravedad provenientes de distintas campañas relevados durante las últimas tres décadas, que forman parte de la base de datos del Instituto Geofísico Sismológico Volponi (IGSV). Se construyeron mapas gravimétricos que luego fueron filtrados con el objetivo de estudiar las fuentes ubicadas en la corteza superior. Consecuentemente se prepararó un modelo en 3D obtenido por inversión gravimétrica, integrando información geológica y geofísica disponible. El modelo 3D del espesor sedimentario tiene en cuenta variaciones laterales y verticales de la densidad obtenidas de afloramientos y de pozos de exploración de hidrocarburos. Esto permitió identificar altos y bajos estructurales estudiados en 2D por otros autores e identificar una subcuenca, no reportada hasta el presente, en el borde este de la faja plegada y corrida de Malargüe y que se acuña con los afloramientos del basamento cristalino del Bloque de San Rafael.","palabras_clave":"HIDROCARBUROS|GRAVIMETRIA 3D|ESPESORES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38106,"idioma_id":4,"titulo":"GOCE derived vertical gravity gradient delineates great earthquake rupture zones along the Chilean margin","resumen":"A traves de las zoans de maximo gardente gravimetrico tomadas del modelo EGM08 se observan als superficies de ruptura de grandes terremotos asociados a zoans de subduccion y sus zonas de maximo desplazamiento interno","palabras_clave":"GOCE|Vertical Gravity Gradient|Rupture Zones|Earthquake|High|Trench Sediments"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38107,"idioma_id":4,"titulo":"Novel Mutation p.A64D in the Serpina 7 Gene as a Cause of Complete Thyroxine-Binding Globulin Deficiency Associated with Increases Affinity in Transthyretin by a Known p.A109T Mutation in the TTR Gene.","resumen":"Partial thyroxine?binding globulin deficiency (TBG-PD) is an endocrine defect with a prevalence of 1:4,000 newborn. Due to the presence of a single TBG gene on the X chromosome, most familial TBG defects follow a X-linked inheritance pattern. Abnormal T4 binding to T4-binding prealbumin (TTR) is a rare cause of euthyroid hiperthyroxinemia which is transmitted by autosomal dominant inheritance. The purpose of the present study was identify and characterize new mutations in the Serpine 7 and TTR genes in a complete family with typical TBG-PD. All patients underwent clinical and biochemical evaluation. Sequencing of DNA, population screening by (SSCP) analysis, and bioinformatics studies were performed. Molecular studies revealed a novel p.A64D mutation in the exon 1 of Serpina 7 gene associated with the previously reported p.A109T mutation in the exon 4 of TTR gene. To our knowledge, this is the first report of a patient with a TBG-PD by a mutation in Serpina 7 that was coincident with a mutation in TTR gene that increased affinity of TTR for T4. This work contributes to elucidate the molecular basis of the defects of thyroid hormone transport in serum and the improvement of the diagnosis avoiding unnecessary therapy. ","palabras_clave":"THYROXINE-BINDING GLOBULIN|TRANSTHYRETIN|PARTIAL TBG DEFICIENCY|EUTHYROID HYPER-THYROXINEMIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38108,"idioma_id":4,"titulo":"Intermediate filament proteins expression and carbohydrate moieties in trophoblast and decidual cells of mature cat placenta","resumen":"The aim of the present study was to characterize cytoskeletal intermediate filament  proteins and glycoconjugates of syncytiumtrophoblast, cytotrophoblast and decidual cells  of feline endotheliochorial placenta. Samples from 12 normal pregnant female cats, after  45±5 days of gestation were obtained removing the uterine horns by hysterectomy.  Sections were processed for routine observation and for immunohistochemistry using anti  cytokeratin, anti vimentin and anti desmin antibodies. BesidesIn addition, lectin  histochemistry was performed using a panel of several biotinylated lectins to characterise  glycosides expression profile. Cytotrophoblast and syncytiotrophoblast showed  immunoreactivity only with acidic and basic cytokeratins. Decidual cells were only positive  to vimentin, sustaining consistent with their origin from endometrial fibroblasts.  Trophoblast expressed a broad population of glycans, highly exposing terminal N-Acetyl  glucosamine residues and non sialylated galactose and N-Acetyl galactosamine oligomers.  Oligosaccharides bound by Phaseolus vulgaris erythroagglutinin were the only highly  branched N-linked residues evidenced in cats, and they were restricted to the syncytium.  Unlike results reported on humans, mice and rats on lectin affinity of decidual cells, sialid  acids and complex N-linked oligosaccharides were not demonstrated in cats.  Glycosylation of proteins determines many of their final properties, thus becoming essential  for the embryo-maternal dialogue during implantation and placentation. Changes in  glycosylation pattern have been related to pathological pregnancies in other species. Hence,  the knowledge about glycosylation profile of the normal cat placenta may lead to a better  understanding of both normal and pathological reproductive events.","palabras_clave":"Feline,    |Endotheliochorial placentation,|Cytotrophoblast  cells , |Syncytiotrophoblast, |Decidualization,|Glycoconjugates, |Cytokeratins,|Vimentin,|Ddesmin."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38109,"idioma_id":4,"titulo":"What do we know about armadillos? An analysis of four centuries of knowledge about a group of South American mammals, with emphasis on their conservation","resumen":"1. Basic knowledge on the biology and ecology of a species is fundamental for the realistic assessment of its conservation status and for planning effective conservation strategies. The latest assessment of the 21 extant armadillo species (Xenarthra, Dasypodidae) by the International Union for Conservation of Nature (IUCN) for its Red List of Threatened Species shows that considerable gaps exist in our knowledge of these Neotropical mammals. 2. Our goal was to analyse the existing literature on armadillos to define thematic and regional research priorities that will eventually benefit their conservation. 3. We categorized 3117 publications on extant armadillos published between 1660 and 2011 according to their research topic, species studied, country and publication language. 4. The number of publications per research topic and the number per species were very variable. The nine best-studied species are classed as Least Concern by the IUCN, while three of the four least-studied species are classed as Data Deficient. At least one field study was done in each range country, but over 80% of field research took place in the USA, Brazil, Argentina and Bolivia. Most research was done in the USA on leprosy in Dasypus novemcinctus. Most ecological research has been focused on four species, and data on the ecology of Data Deficient and Vulnerable taxa are virtually absent. 5. Field research on armadillos should be intensified to broaden conservation relevant knowledge. Additional studies in the Guianas, Peru, Ecuador, Colombia, Venezuela and Paraguay are urgently needed to assess the conservation status of armadillos in these regions. Future research should focus on ecology, conservation, population genetics, reproduction and threats. Species priorities should include country endemics, such as Dasypus pilosus (Peru), Tolypeutes tricinctus (Brazil) and Dasypus yepesi and Chlamyphorus truncatus (Argentina), as well as other Data Deficient and Vulnerable species, especially Cabassous centralis and Calyptophractus retusus.","palabras_clave":"Cingulata|Dasypodidae|Research priorities|Threatened species|Xenarthra"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38110,"idioma_id":4,"titulo":"Regulation of extracellular ATP in human erythrocytes infected with Plasmodium falciparum","resumen":"    In human  erythrocytes (h-RBCs) various stimuli induce increases in [cAMP] that trigger  ATP release. The resulting pattern of extracellular ATP accumulation (ATPe  kinetics) depends on both ATP release and ATPe degradation by ectoATPase  activity. In this study we evaluated ATPe kinetics from primary cultures of  h-RBCs infected with P. falciparum at various stages of infection (ring,  trophozoite and schizont stages). A ??3V?? mixture containing isoproterenol  (b-adrenergic agonist), forskolin (adenylate kinase activator) and papaverine  (phosphodiesterase inhibitor) was used to induce cAMP-dependent ATP release.  ATPe kinetics of r-RBCs (ring-infected RBCs), t-RBCs (trophozoite-infected  RBCs) and s-RBCs (schizont-infected RBCs) showed [ATPe] to peak acutely to a  maximum value followed by a slower time dependent decrease. In all  intraerythrocytic stages, values of DATP1 (difference between [ATPe] measured 1  min post-stimulus and basal [ATPe]) increased nonlinearly with parasitemia  (from 2 to 12.5%). Under 3V exposure, t-RBCs at parasitemia 94% (t94-RBCs)  showed 3.8-fold higher DATP1 values than in h-RBCs, indicative of upregulated  ATP release. Pre-exposure to either 100 mM carbenoxolone, 100 Nm mefloquine or  100 mM NPPB reduced DATP1 to 83?87% for h-RBCs and 63?74% for t94-RBCs.  EctoATPase activity, assayed at both low nM concentrations (300?900 nM) and 500  mM exogenous ATPe concentrations increased approx. 400-fold in t94- RBCs, as  compared to h-RBCs, while intracellular ATP concentrations of t94-RBCs were 65%  that of h-RBCs. In t94-RBCs, production of nitric oxide (NO) was approx. 7-fold  higher than in h-RBCs, and was partially inhibited by L-NAME pretreatment. In  media with L-NAME, DATP1 values were 2.7-times higher in h-RBCs and 4.2-times  higher in t94-RBCs, than without L-NAME. Results suggest that P. falciparum  infection of h-RBCs strongly activates ATP release via Pannexin 1 in these cells.  Several processes partially counteracted ATPe accumulation: an upregulated ATPe  degradation, an enhanced NO production, and a decreased intracellular ATP  concentration.  ","palabras_clave":"MALARIA|ECTOATPASE|NUCLEOTIDE|CELL SIGNALING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38111,"idioma_id":4,"titulo":"An Attenuated Projector for Iterative Reconstruction Algorithm of a High Sensitivity Tomographic Gamma Scanner","resumen":"Tomographic Gamma Scanners are tools for nondestructive assay and characterization of nuclear waste drums. In these scanners, a three dimensional image of the activity distribution of every radioisotope stored in the drum is obtained by performing a single-photon emission tomography. AR-TGS is a novel architecture of tomographic gamma scanners that combines an HPGe detector with six NaI(Tl) detectors in order to achieve high-sensitivity. In this work, a projector for a 2D MLEM reconstruction algorithm of AR-TGS is presented. This projector models the geometry of the system, the collimator?s response and the attenuation in the field of view by performing a ray-tracing with several lines of response per detector. The projector was evaluated with Monte Carlo simulations of different phantoms and with experimental measurements. The algorithm proved to be an accurate model of the acquisition process and was used to reconstruct data sets with different strategies, such as utilising matched and unmatched projector\/backprojector pairs. The results showed that the use of this projector in image reconstruction considerably improved spatial resolution and image quality compared with an attenuated Siddon projector. The quantification properties of the algorithm for homogeneous and heterogeneous drums matrices were also analyzed.","palabras_clave":"Image reconstruction|tomographic gamma scanner|SPECT|projector"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38112,"idioma_id":4,"titulo":"Estimating forage quantity and quality under different stress and senescent biomass conditions via spectral reflectance","resumen":"Assesing forage quantity and quality through remote sensing can facilitate grassland and pasture management. However, the high spatial and temporal variability of canopy conditions may limit the predictive accuracy of models based on reflectance measurements. The objective of this work was to develope this type of models, and to challenge their capacity to predict plant properties under a wide range of environmental conditions. We manipulated Paspalum dilatatum canopies through different stress treatments (flood, drought, nutrient availability, and control) and by artificially varying the amount of senescent biomass. We measured canopy reflectance and constructed simple models, based on either normalized vegetation indices or a few selected wavebands, to estimate biomass and to variables related to forage quality: proportion of photosynthetic vegetation and biomass C:N ratio. General models satisfactorily predicted plants properties for the whole set of environmental conditions, but failed under specific conditions such as drought (for esitmates of plant biomass), fertilization (for estimates of C:N ratio), and different levels of senescent tillers (for estimates of the proportion of photosynthetic vegetation). Where general models failed, specific models, based on different bands, achieved satisfactory accuracy. The generals models performed better when based on a few selected than when based on two-band vegetation indices, having better accuracy (higher R2)and parsimony (lower BIC). However specific models performed similarly for both approaches (similar R2 and BIC). This results indicate that these plant properties can be predicted from reflectance information under a broad range of conditions, but no for some particular conditions, where ancillary data or more complex models are probably needed to increase predictive accuracy.","palabras_clave":"forage quantity and quality"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38113,"idioma_id":4,"titulo":"Effects of probiotics in broilers growth performance: A meta-analysis of randomized controlled trials","resumen":"1.For many years, feed supplementation with antibiotics has been used to stabilize the gut flora, improve broilers? general parameters and prevent avian diseases. However, with the increasing concern about antibiotic resistance, the need of alternatives has been widely recognized, the supplementation of broiler diets with probiotics being one potential method. However, a consensus among authors about benefits derived from probiotics has not been reached.   2.The aim of this meta-analysis has been to establish the effects of probiotics on the growth performance of broilers (i.e., body weight gain (BWG) and feed efficiency (FE)). PubMed, Scopus and Scholar Google databases were searched from 1980 to 2012, regardless of the language used. The studies in the meta-analysis were selected on the basis of following inclusion criteria: randomized and controlled experiments using broilers without apparent disease and published in peer-reviewed journals studies.  3.Forty eight and forty six studies were included to assess probiotic effects on BWG and feed efficiency, respectively. Probiotics increased BWG compared to controls (SMD= 0.661, 95%CI 0.499?0.822) and enhance FE (SMD= &#8722;0.281, 95%CI &#8722;0.404 to &#8722;0.157) in the pooled standardized mean difference random effect model, considering the source of heterogeneity and publication biases.   4.The findings of this meta-analysis showed that application via water resulted in greater BGW and FE than administration through the feed. The result is not related to the use of mono-strain or multi-strain probiotics, although it may depend on the strain used. The number of broilers and the duration of the experiments had an impact on the outcomes.  5.However, there are evidences of publication bias and heterogeneity, so the results of this meta-analysis should be considered with caution. Additional studies should be conducted with the aim to identify the covariates which can explain the differences in the estimated effect sizes.","palabras_clave":"BROILERS|PROBIOTICS|GROWTH PERFORMANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38114,"idioma_id":5,"titulo":"Conocimiento de las vías de transmisión de las zoonosis y de las especies afectadas entre los trabajadores rurales","resumen":"El objetivo de este trabajo fue evaluar el grado de conocimiento que tienen los trabajadores rurales sobre las zoonosis a las que se encuentran expuestos en su trabajo y su asociación con factores socio-demográficos. Se efectuó un estudio observacional transversal  basado en la realización de encuestas (N = 110, n = 94), utilizando un cuestionario estructurado. El análisis incluyó &#967;2, t de Student y correlación de Pearson y de Spearman. Las zoonosis más conocidas fueron la triquinosis, la rabia y la sarna. En el caso de la brucelosis, la tuberculosis y el carbunco, fueron muy conocidas las especies que las  transmiten, pero no así las formas de transmisión. Las enfermedades menos conocidas en ambos sentidos fueron la toxocariasis y la hidatidosis, seguidas por la leptospirosis y la toxoplasmosis. Para todas las zoonosis estudiadas se encontró correlación signifi cativa (p< 0,001) entre el conocimiento de las especies transmisoras y de las vías de transmisión.  Aquellos encuestados de sexo masculino, propietarios y residentes de zonas urbanas, casados y de mayor edad y antigüedad fueron quienes presentaron más conocimientos sobre las zoonosis, en general. El conocimiento que tienen los trabajadores rurales acerca de las zoonosis es insuficiente. Sería importante que los veterinarios, en conjunto con las aseguradoras de riesgos del trabajo, difundan la información adecuada entre las personas en riesgo que desarrollan sus tareas en este ámbito.","palabras_clave":"CONOCIMIENTO|TRABAJADOR RURAL|ZOONOSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38115,"idioma_id":4,"titulo":"RISK FACTORS ASSOCIATED WITH THE PRESENCE OF VARROA DESTRUCTOR IN HONEY BEE COLONIES FROM EAST-CENTRAL ARGENTINA","resumen":"caused by varroa mite includes body weight loss, malformation and weakening of the bees. It was also suggested as the main cause associated with colony winter mortality and as an important vector for several honey bee viruses. Little is known about multiple factors and their interaction affecting V. destructor prevalence in apiaries from South America. The aim of this study was to identify risk factors associated with V. destructor prevalence in east-central Argentina. Parasitic mite infestation level and colony strength measures were evaluated in 63 apiaries distributed in 4 different regions in east-central Argentina in a cross sectional study. Data regarding management practices in each apiary were collected by means of a questionnaire. A mixed-effects logistic regression model was constructed to associate management variables with the risk of achieving mite infestation higher than 3%. Colonies owned by beekeepers who indicated that they did not monitor colonies after mite treatment (OR = 2.305; 95% CI: 0.944?5.629) nor disinfect hives woodenware material (OR = 2.722; 95% CI: 1.380?5.565) were associated with an increased risk of presenting high intensity infestation with V. destructor (>3%). On the other hand, beekeepers who reported replacing more than 50% of the queens in their operation (OR = 0.305; 95% CI: 0.107?0.872), feeding colonies protein substitute containing natural pollen (OR = 0.348; 95% CI: 0.129?0.941) and feeding colonies High Fructose Corn Syrup (HFCS) (OR = 0.108; 95% CI: 0.032?0.364), had colonies that were less likely to have V. destructor infestations above 3%, than beekeepers who did not report using these management practices. Further research should be conducted considering that certain management practices were associated to mite infestation level in order to improve the sanitary condition in the colonies. Epidemiological studies provide key information to design surveillance programs against one the major threat to worldwide beekeeping.","palabras_clave":"RISK FACTORS|VARROA DESTRUCTOR|APIS MELLIFERA|MANAGEMENT PRACTICES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38116,"idioma_id":5,"titulo":"Identificación de factores de riesgos asociados a la presentación de endometritis en bovinos lecheros","resumen":"El objetivo del presente trabajo fue identificar factores asociados a la presentación de endometritis en vacas lecheras posparto. Se muestrearon 152 vacas (aproximadamente con 40 días posparto) pertenecientes a cuatro establecimientos de producción lechera de Argentina. Los sistemas productivos se caracterizaban por ser de tipo pastoriles base alfalfa con suplementación estratégica, con un promedio diario de 19 litros\/animal. La metodología del muestro consistió en higienizar la zona vulvar con yodo povidona y papel descartable. Seguidamente se tomó la muestra del contenido uterino introduciendo el Metrichecktm y se lo observó clínicamente  para efectuar una clasificación en grados de endometritis (escala de 0 a 3). De cada vaca se tomaron datos sobre número de lactancia, genética, tipo de parto, condición corporal, sexo de las crías para la identificación de los factores asociados a la presencia de endometritis. Para dichas asociaciones se empleó Chi-cuadrado, test exacto de Fisher, T-student y regresión logística. El 70% de las vacas no presentaron anormalidades en el flujo uterino o mostraron un grado leve de endometritis. Las endometritis con grado mayor a dos estuvieron asociadas a partos distócicos (Odds Ratio=OR= 9,6), retención de membranas fetales (OR= 4,4) y vacas melliceras (OR= 5,1). El registro de los factores de riesgo, la revisión sistemática posparto, la utilización de herramientas que facilitan la inspección (Ej.: Metrichecktm) y la capacitación continua de todos los actores que intervienen en el sistema productivo, son aspectos relevantes a considerar para emitir un diagnóstico certero de endometritis y aplicar medidas de profilaxis y\/o curativas tendientes a lograr un corto intervalo entre partos.","palabras_clave":"ENDOMETRITIS|BOVINOS|DIAGNÓSTICO|FACTORES DE RIESGO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38117,"idioma_id":4,"titulo":"Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats","resumen":"Diabetes mellitus type 2 (DM2) is a disease with increasing importance in modern societies and insufficient treatment options. Pharmacological stimulation of insulin signaling, which is blunted in DM2, is a promising approach to treat this disease. It has been shown that activation of the angiotensin (Ang)-(1-7)\/Mas axis of the renin-angiotensin system leads to an improved glucose uptake. In this study, we intended to evaluate, whether this effect could be exploited therapeutically. We first confirmed that Ang-(1-7) improves insulin signaling and glucose uptake in vitro in cultured cardiomyocytes. We then evaluated the therapeutic effect of a newly developed hydro-xypropyl-&#946;-cyclodextrin-based Ang-(1-7) nano-formulation in a novel transgenic rat model of inducible insulin resistance and DM2. The chronic administration of this compound prevented the marked elevation in blood glucose levels in these rats at a dose of 30 &#956;g\/kg, reversed the established hyperglycemic state at a dose of 100 &#956;g\/kg, and resulted in improved insulin sensitivity, reduced plasma insulin and decreased diabetic nephropathy. In conclusion, an oral Ang-(1-7) formulation reverses hyperglycemia and its consequences in an animal model of DM2 and represents a novel therapeutic option for the treatment of DM2 and other cardio-metabolic diseases.    KEY MESSAGE:  A novel rat model with inducible diabetes can be used to evaluate new therapies. Angiotensin-(1-7) is effective in an oral formulation packaged in cyclodextrine. Angiotensin-(1-7) is a promising antidiabetic drug.","palabras_clave":"ANGIOTENSIN-(1-7)|DIABETES|INSULIN|METABOLIC SYNDROME"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38118,"idioma_id":4,"titulo":"Mitogenic Effects of Phosphatidylcholine Nanoparticles on MCF-7 breast cancer cells","resumen":"Lecithins, mainly composed of the phospholipids phosphatidylcholines (PC), have many different uses in the pharmaceutical and clinical field. PC are involved in structural and biological functions as membrane trafficking processes and cellular signaling. Considering the increasing applications of lecithin-based nanosystems for the delivery of therapeutic agents, the aim of the present work was to determine the effects of phosphatidylcholine nanoparticles over breast cancer cellular proliferation and signaling. PC dispersions at 0.01 and 0.1% (w\/v) prepared in buffer pH 7.0 and 5.0 were studied in the MCF-7 breast cancer cell line. Neutral 0.1% PC-derived nanoparticles induced the activation of the MEK-ERK1\/2 pathway, increased cell viability and induced a 1.2 fold raise in proliferation. These biological effects correlated with the increase of epidermal growth factor receptor (EGFR) content and its altered cellular localization. Results suggest that nanoparticles derived from PC dispersion prepared in buffer pH 7.0 may induce physicochemical changes in the plasma membrane of cancer cells which may affect EGFR cellular localization and\/or activity, increasing activation of the MEK-ERK1\/2 pathway and inducing proliferation. Results from the present study suggest that possible biological effects of delivery systems based on lecithin nanoparticles should be taken into account in pharmaceutical formulation design.","palabras_clave":"Phosphatidylcholine|Nanoparticles|Mitogenic Effects"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38119,"idioma_id":4,"titulo":"Activation of the ERK2 in Basolateral amygdala underlies the promoting influence of stress on fear memory and anxiety: Influence of midazolam pretreatment","resumen":"Exposure to emotionally arousing experiences elicits a robust and persistent memory and enhances anxiety. The amygdala complex plays a key role in stress-induced emotional processing and in fear memory formation. It is well known that ERK activation in the amygdala is a prerequisite for fear memory consolidation. Moreover, stress elevates p-ERK2 levels in several areas of the brain stress circuitry. Therefore, given that the ERK1\/2 cascade is activated following stress and that the role of this cascade is critical in the formation of fear memory, the present study investigated the potential involvement of p-ERK2 in amygdala subnuclei in the promoting influence of stress on fear memory formation and on anxiety-like behavior. A robust and persistent ERK2 activation was noted in the Basolateral amygdala (BLA), which was evident at 5 min after restraint and lasted at least one day after the stressful experience. Midazolam, a short-acting benzodiazepine ligand, administered prior to stress prevented the increase in the p-ERK2 level in the BLA. Pretreatment with intra-BLA infusion of U0126 (MEK inhibitor), but not into the adjacent central nucleus of the amygdala, attenuated the stress-induced promoting influence on fear memory formation. Finally, U0126 intra-BLA infusion prevented the enhancement of anxiety-like behavior in stressed animals. These findings suggest that the selective ERK2 activation in BLA following stress exposure is an important mechanism for the occurrence of the promoting influence of stress on fear memory and on anxiety-like behavior.","palabras_clave":"BASOLATERAL AMYGDALA|STRESS|ERK2|FEAR MEMORY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38120,"idioma_id":4,"titulo":"Mitochondrial morphofunctional alterations in smooth muscle cells of aorta in rats","resumen":"In an experimental model of atherogenesis induced by hyperfibrinogenemia (HF), the pharmacological response of vitamin E was studied in order to assess its antioxidant effect on the mitochondrial morphofunctional alterations in aortic smooth muscle cells. Three groups of male rats were used: (Ctr) control, (AI) atherogenesis induced for 120 days, and (AIE) atherogenesis induced for 120 days and treated with vitamin E. HF was induced by adrenalin injection (0.1 mg\/day\/rat) for 120 days. AIE group was treated with the administration of 3.42mg\/day\/rat of vitamin E for 105 days after the first induction. Mitochondria morphology was analyzed by electronic microscopy (EM) and mitochondrial complexes (MC) by spectrophotometry. In group AI the total and mean number of mitochondria reduced significantly, the intermembranous matrix increased, and swelling was observed with respect to Ctr and AIE (p < 0.01). These damages were related to a significant decrease in the activity of citrate synthase and complexes I, II, III, and IV in group AI in comparison to Ctr (p < 0.001). Similar behavior was presented by group AI compared to AIE (p < 0.001). These results show that vitamin E produces a significative regression of inflammatory and oxidative stress process and it resolved the morphofunctional mitochondrial alterations in this experimental model of atherogenic disease.","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38121,"idioma_id":4,"titulo":"The major egg reserve protein from the invasive apple snail Pomacea maculata is a complex carotenoprotein related to those of Pomacea canaliculata and Pomacea scalaris","resumen":"Snails from the genus Pomacea lay conspicuous masses of brightly colored eggs above the water. Coloration is given by carotenoproteins that also which play important roles in protection against sun radiation, stabilizing and transporting antioxidant molecules and helping to protect embryos from desiccation and predators. They seem a key acquisition, but have been little studied. Here we report the characteristics of the major carotenoprotein from Pomacea maculata and the first comparison among these egg proteins. This particle, hereafter PmPV1, represents ~52% of perivitellin fluid protein. It is a glyco-lipo-carotenoprotein responsible for the bright reddish egg coloration.With VHDL characteristics, PmPV1 apparent molecularmass is 294 kDa, composedof five non-covalently bound subunits of pI 4.7?9.8 and masses between 26 and 36 kDa whose N-terminal sequences were obtained. It is a glyco-lipo-carotenoprotein scarcely lipidated (b1%) but highly glycosilated (13% by wt). Lipids include phospholipids, free fatty acids and carotenoids; mannose and galactose predominate over othermonosaccharides.Main carotenoids are esterified and non-esterified astaxanthin (71 and 25%, respectively). Carotenoid removal does not seem to affect the structural characteristics of the oligomer, while deglycosilation reduces subunit number from five to a single one. The carotenoid?protein association protected the former against oxidation. PmPV1 cross reacts with polyclonal antibodies against the PcOvo, the major carotenoprotein from Pomacea canaliculata. The characterization of PmPV1 allows the first comparisons among snail carotenoproteins and further highlights the importance of these perivitellins in the reproductive strategy of Pomacea.","palabras_clave":"antioxidant|carotenoprotein|carotenoid|perivitellin|egg|snail"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38122,"idioma_id":4,"titulo":"Building a Species Conservation Strategy for the brown howler monkey (Alouatta guariba clamitans) in Argentina in the context of yellow fever outbreaks","resumen":"The brown howler monkey (Alouatta guariba clamitans) is endemic to South America?s Atlantic Forest, with a small    population extending into the northern portion of Misiones province in northeastern Argentina. In 2012, the species was    classified as Critically Endangered in Argentina due to its highly restricted distribution, low population density and dramatic    declines from recent Yellow Fever outbreaks. In March 2013, we organized an international workshop in Misiones to evaluate    population status in Argentina and conduct a threat analysis. We developed population viability models using Vortex and    Outbreak software packages. These tools allowed us to explore how several biological and demographic parameters of brown    howlers, as well as factors related to Yellow Fever epidemiology, affect the probability of species extinction. The discussion    among diverse specialists and analysis of model results identified Yellow Fever as the main threat to brown howler population    persistence in Argentina. Our threat analysis, focused on the dynamics of Yellow Fever outbreaks and their impact on howler    populations, led to the identification of gaps in knowledge that helped prioritize objectives and actions for the development    of a Species Conservation Strategy in Argentina.","palabras_clave":"Alouatta guariba clamitans|Population Viability Analysis|Threat Analysis|Yellow Fever"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38123,"idioma_id":4,"titulo":"MYH9-related disease: a novel prognostic model to predict the clinical evolution of the disease based on genotype-phenotype correlations","resumen":"MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in the gene for non-muscle myosin heavy chain IIA (NMMHC-IIA). MYH9-RD is characterized by a considerable variability in clinical evolution: patients present at birth with only thrombocytopenia, but some of them subsequently develop sensorineural deafness, cataract, and\/or nephropathy often leading to end-stage renal disease (ESRD). We searched for genotype-phenotype correlations in the largest series of consecutive MYH9-RD patients collected so far (255 cases from 121 families). Association of genotypes with non-congenital features was assessed by a generalized linear regression model. The analysis defined disease evolution associated to seven different MYH9 genotypes that are responsible for 85% of MYH9-RD cases. Mutations hitting residue R702 demonstrated a complete penetrance for early-onset ESRD and deafness. The p.D1424H substitution associated with high risk of developing all the non-congenital manifestations of disease. Mutations hitting a distinct hydrophobic seam in the NMMHC-IIA head domain or substitutions at R1165 associated with high risk of deafness but low risk of nephropathy or cataract. Patients with p.E1841K, p.D1424N and C-terminal deletions had low risk of non-congenital defects. These findings are essential to patients? clinical management and genetic counseling and are discussed in view of molecular pathogenesis of MYH9-RD.","palabras_clave":"MYH9|MIOSINA NO MUSCULAR IIA|TROMBOCITOPENIA|HEREDITARIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38124,"idioma_id":4,"titulo":"Prevalence of cardiovascular risk factors among Latin American adolescents: a multilevel analysis","resumen":"High blood pressure (HBP) and obesity is a well-established major risk factor for stroke and coronary heart disease. However, the literatures are scarce about these informations in adolescents from low-and-middle income countries. This school-based survey was carried out among students from Maringá (Brazil) and Buenos Aires (Argentina) selected random sampling. We studied 991 Brazilian adolescents (54.5% girls) in the age range of 14-18 years. In Argentina, we studied 933 adolescents (45.9% female) in the age range of 11-17 years. The outcomes of this study are general obesity, abdominal obesity and HBP. The associated factors analysed were gender, age and health behaviours. The prevalence of obesity was 5.8% in Brazil and 2.8% in Argentina, the prevalence of abdominal obesity was 32.7% in Brazil and 11.1% in Argentina, the prevalence of HBP was 14.9% in Brazil and 13.5% in Argentina. The multilevel analysis showed that older adolescents (&gt;14 years old) have a little likelihood of being overweight, whereas male adolescents are more likely to be obese and have HBP. The abdominal obesity in both indicators were not associated with the independent variables. The prevalence of cardiovascular risk factors is high in Latin American adolescents independent of each country, and was associated with male gender.","palabras_clave":"cardiovascular risk|latin american"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38125,"idioma_id":4,"titulo":"Effect of insulin-resistance on circulating and adipose tissue MMP-2 and MMP-9 activity in rats fed a sucrose-rich diet","resumen":"BACKGROUND AND AIM:  Adipose tissue produces different metalloproteinases (MMPs), involved in adipogenesis and angiogenesis. Different studies have shown that in obesity the behavior of different MMPs may be altered. However there are scarce data about the effect of insulin-resistance (IR) on MMP-2 and MMP-9 activity in adipose tissue. Our aim was to determine whether sucrose induced IR modifies MMP-2 and MMP-9 behavior in expanded visceral adipose tissue and the contribution of this tissue to circulating activity of these gelatinases.  METHODS AND RESULTS: Male Wistar rats were fed with standard diet (Control) or standard diet plus 30% sucrose in the drinking water throughout 12 weeks (SRD). In epididymal adipose tissue vascular density, size and adipocyte density, PPAR&#947; expression and MMP-2 and -9 were measured. Adipose tissue from SRD presented higher adipocyte size (6.32 ± 8.71 vs 4.33 ± 2.17 × 10(3) &#956;m(2), p = 0.001) lower adipocyte density (164 (130-173) vs 190 (170-225) number\/mm(2), p = 0.046) and lower vascular density (16.2 (12.8-23.5) vs 28.1 (22.3-46.5) blood vessels\/mm(2), p = 0.002) than Control. MMP-2 and MMP-9 activity was decreased in SRD (1.93 ± 0.7 vs 3.92 ± 0.9 relative units, p = 0.048 and 1.80 ± 0.8 vs 5.13 ± 1.7 relative units, p = 0.004 respectively) in accordance with lower protein expression (0.35 ± 0.20 vs 2.71 ± 0.48 relative units, p = 0.004 and 1.12 ± 0.21 vs 1.52 ± 0.05 relative units, p = 0.036 respectively). There were no differences in PPAR&#947; expression between groups.  CONCLUSION: Insulin resistance induced by SRD decreases MMP-2 and MMP-9 activity in adipose tissue which would not represent an important source for circulating MMP-2 and -9. In this state of IR, PPAR&#947; would not be involved in the negative regulation of adipose tissue gelatinases.","palabras_clave":"Adipose tissue; Atherosclerotic plaque; Insulin-resistance; Metalloproteinase"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38126,"idioma_id":4,"titulo":"Effect of secochiliolide acid isolated from the Patagonian shrub Nardophyllum bryoides as active component in antifouling paints","resumen":"Environmental concerns about the use of toxic antifoulants have led to an increased interest in the  development of new alternatives. So far, most of the antifouling natural products have been obtained  from marine organisms. However, some secondary metabolites from terrestrial plants could be promising  antifoulant candidates. The antifouling performance of secochiliolide acid, the main component  isolated from Nardophyllum bryoides ethanolic extract, was evaluated for inclusion in rosin-based  coatings.  Field testing was conducted during the summer months at Mar del Plata harbor, Argentina. The results  indicated that secochiliolide acid-based paints completely inhibited the settlement of Bugula neritina  colonies, Polydora sp., Hydroides elegans, Corophium sp. and solitary ascidians, and also reduced the  attachment of some algae as Enteromorpha intestinalis and Ectocarpus sp. In addition, a lower density and  diversity of microfouling species was registered.  These results highlighted the importance of terrestrial plants as a sustainable source of potential  environmentally friendly antifoulants.","palabras_clave":"SECOCHILIOLIDE ACID|TERPENOIDS|NARDOPHYLLUM BRYOIDES|SOLUBLE MATRIX ANTIFOULING PAINTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38127,"idioma_id":4,"titulo":"Defect spectroscopy of single ZnO microwires","resumen":"The point defects of single ZnO microwires grown by carbothermal reduction were studied bymicrophotoluminescence, photoresistance excitation spectra, and resistance as a function of thetemperature. We found the deep level defect density pro&#64257;le along the microwire showing that theconcentration of defects decreases from the base to the tip of the microwires and this effectcorrelates with a band gap narrowing. The results show a characteristic deep defect levels insidethe gap at 0.88 eV from the top of the VB. The resistance as a function of the temperature showsdefect levels next to the bottom of the CB at 110 meV and a mean defect concentration of41018 cm3. This combination of techniques allows us to study the band gap values and defectsstates inside the gap in single ZnO microwires and opens the possibility to be used as a defectspectroscopy method.","palabras_clave":"SPECTROSCOPY|DEFECT|ZNO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38128,"idioma_id":4,"titulo":"Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant","resumen":"Foot and mouth disease is an acute disease of cattle with a broad distribution around the world. Due to the fast spread of FMDV infections, control measures must be applied immediately after an outbreak, such as the use of vaccines that induce fast protection. Previously, it was shown that mice vaccinated with FMD inactivated virus (iFMDV) formulated with Montanide? ESSAI IMS D 12802 VG PR adjuvant (802-iFMDV) were protected when they were challenged 4 and 7 days post-vaccination (dpv) with homologous virus. In this work, we describe the successful use of this formulation in cattle. In addition, adjuvant Montanide? IMS 1313 VG NPR was also tested. 802-iFMDV vaccine was able to confer 100% protection against viral challenge at 4 and 7 dpv, while eliciting low antibody levels, at 7 dpv. 1313-iFMDV vaccine induced protection in 60% of cattle. At 4 dpv, 1313-iFMDV vaccinated animals presented increased levels of IFNã but not of macrophages. At 4 and 7 dpv, macrophages, IFNã, nasal IgA and IgG1 antibodies against FMDV, and opsonophagocytosis were increased in animals vaccinated with 802-iFMDV indicating that these phenomena could be involved in protection.It is the first time that total protection against FMDV at early stages post-vaccination is reported using a single dose of the formulation iFMDV plus Montanide? ESSAI D IMS 12802 VG PR adjuvant.","palabras_clave":"Adjuvant|Early protection|FMDV"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38129,"idioma_id":4,"titulo":"Cross-linked &#945;-L-rhamnosidase aggregates with potential application in food industry","resumen":"Alpha-l-Rhamnosidase (E.C. 3.2.1.40) from Brevundimonas sp. Ci19 was immobilized as a cross-linked enzyme aggregate (CLEA) via precipitation with acetone followed by glutaraldehyde cross-linking. The effects of precipitation and cross-linking on CLEA activity were investigated and characterized. Sixty percent acetone solution and 2.0 % glutaraldehyde were used at pH 7.0 for 1-h cross-linking reaction. The rhamnosidase-CLEA yield was approximately 80 % starting from&nbsp; crude extracts o pure enzyme suggesting non-purification steps are required for enzyme extended use. No significantdifferences in optimum pH and temperature values of the enzyme were recorded after immobilization. The rham-CLEA recycled 4 times showed about 80 % rhamnosidase activity; meanwhile, in the fifth and six recycled time, the enzyme activity was reduced to about 40 and 20 % respectively.","palabras_clave":"Alpha-l-rhamnosidase|CLEA|Biotransformation|Immobilization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38130,"idioma_id":4,"titulo":"Flow Cytometric microsphere-based immunoassay as a novel non-radiometric method for the detection of glutamic acid decarboxylase autoantibodies in type 1 Diabetes Mellitus","resumen":"The first measurable sign of arising autoimmunity in type 1 diabetes mellitus   is the detection of autoantibodies against beta-cell antigens, such as   glutamic acid decarboxylase (GAD65). GAD65 autoantibodies (GADA) are   usually measured by the Radioligand Binding Assay (RBA). The aim of this   work was to develop protocols of flow cytometric microsphere-based   immunoassays (FloCMIA) which involved glutamic acid decarboxylase fused   to thioredoxin (TrxGAD65) adsorbed on polystyrene microspheres.   Detection of bound GADA was accomplished by the use of anti-human   IgG-Alexa Fluor 488 (protocol A), anti-human IgG-biotin and   streptavidin-dichlorotriazinyl aminofluorescein (DTAF) (protocol B) or   TrxGAD65-biotin and streptavidin-DTAF (protocol C). Serum samples   obtained from 46 patients assayed for routine autoantibodies at   Servicios Tecnológicos de Alto Nivel (STAN-CONICET) were analyzed by   RBA, ELISA and three alternative FloCMIA designs. Protocol C exhibited   the highest specificity (97.8%) and sensitivity (97.4%) and a wide   dynamic range (1.00-134.40 SDs). Samples obtained from 40 new-onset   diabetic patients were also analyzed to further evaluate the performance   of protocol C. The latter protocol showed a sensitivity of 58.6% and a   prevalence of 47.5%. Two patients resulted positive only by FloCMIA   protocol C and its SDs were higher than those of RBA and ELISA, showing a   significantly wide dynamic range. In conclusion, FloCMIA proved to be   highly sensitive and specific, requiring a low sample volume; it is   environmentally adequate, innovative and represents a cost-effective   alternative to traditional GADA determination by RBA and\/or ELISA,   making it applicable to most medium-complexity laboratories","palabras_clave":"DIABETES MELLITUS|MARKERS|FLOW CYTOMETRY|AUTOANTIBODIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38131,"idioma_id":5,"titulo":"Goodness-of-fit test for directional data","resumen":"In this paper, we study the problem of testing the hypothesis whether the density $f$ of a random variable on a sphere belongs to a given parametric class of densities.  We propose two test statistics based on the $L^2$ and  $L^1$ distance between  a nonparametric density estimator adapted to circular data and a  smoothed version of the specified density. The asymptotic distribution of the $L^2$ test statistic is provided under the null and under contiguous alternatives.  We also consider  a bootstrap method to approximate the distribution of both test statistics. Through a simulation study, we explore the moderate sample performance of the proposed tests under the null hypothesis and under different alternatives. Finally, the procedure is illustrated analysing a real data set based on wind directions measurements.","palabras_clave":"asymptotic properties|bootstrap tests|density estimation|hypothesis testing"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38132,"idioma_id":4,"titulo":"Role of SN1 Lipases on Plasma Lipids in Metabolic Syndrome and Obesity","resumen":"      OBJECTIVE:       To assess the phospholipase   activity of endothelial (EL) and hepatic lipase (HL) in postheparin   plasma of subjects with metabolic syndrome (MS)\/obesity and their   relationship with atherogenic and antiatherogenic lipoproteins.   Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as   triglyceride (TG)-hydrolyses to complete the analyses of SN1 lipolytic   enzymes in the same patient.      APPROACH AND RESULTS:       Plasma   EL, HL, and LPL activities were evaluated in 59 patients with MS and 36   controls. A trend toward higher EL activity was observed in MS. EL   activity was increased in obese compared with normal weight group   (P=0.009) and was negatively associated with high-density   lipoprotein-cholesterol (P=0.014 and P=0.005) and apolipoprotein A-I   (P=0.045 and P=0.001) in control and MS group, respectively. HL   activity, as TG-hydrolase, was increased in MS (P=0.025) as well as in   obese group (P=0.017); directly correlated with low-density   lipoprotein-cholesterol (P=0.005) and apolipoprotein B (P=0.003) and   negatively with high-density lipoprotein-cholesterol (P=0.021) in   control group. LPL was decreased in MS (P      CONCLUSIONS:       We   describe for the first time EL and HL activity as phospholipases in   MS\/obesity, being both responsible for high-density lipoprotein   catabolism. Our results elucidate part of the remaining controversies   about SN1 lipases activity in MS and different grades of obesity. The   impact of insulin resistance on the activity of the 3 enzymes determines   the lipoprotein alterations observed in these states.","palabras_clave":"LIPG protein|hepatic lipase|human|lipoprotein lipase|metabolic syndrome X|obesity| phospholipases"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38133,"idioma_id":4,"titulo":"New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase","resumen":"As part of our project pointed at the search of new antiparasitic agents against American trypanosomiasis (Chagas disease) and toxoplasmosis a   series of 2-alkylaminoethyl-1-hydroxy-1,1-bisphosphonic acids has been   designed, synthesized and biologically evaluated against the etiologic   agents of these parasitic diseases, Trypanosoma cruzi and Toxoplasma   gondii, respectively, and also towards their target enzymes, T. cruzi   and T. gondii farnesyl pyrophosphate synthase (FPPS), respectively.   Surprisingly, while most pharmacologically active bisphosphonates have a   hydroxyl group at the C-1 position, the additional presence of an amino   group at C-3 resulted in decreased activity towards either T. cruzi   cells or TcFPPS. Density functional theory calculations justify this   unexpected behavior. Although these compounds were devoid of activity   against T. cruzi cells and TcFPPS, they were efficient growth inhibitors   of tachyzoites of T. gondii. This activity was associated with a potent   inhibition of the enzymatic activity of TgFPPS. Compound 28 arises as a   main example of this family of compounds exhibiting an ED50 value of 4.7 &#956;M against tachyzoites of T. gondii and an IC50 of 0.051 &#956;M against TgFPPS","palabras_clave":"BISOHOSPHONATES|ISOPRENOID|TRYPANOSOMA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38134,"idioma_id":4,"titulo":"Relationships between nuclear magnetic resonance parameters used to characterize weathering spilled oil and soil toxicity in central Patagonia","resumen":"Oil spill in the Central Patagonian zone was studied to evaluate if any   relationship exists between the parameters used to characterize   weathering spilled oil and soil toxicity for two plant species and to   evaluate if the phytotoxicity to local species would be a good index for   the soil contamination. Nuclear magnetic resonance (NMR) structural   indexes and column chromatography compositional indexes were determined   to characterize the oil spill in the soil samples. Bioassays were also   carried out using Lactuca sativa L (reference) and Atriplex lampa   (native species) as test organisms. Measurements of the total petroleum   hydrocarbon (TPH) and the electrical conductivity (EC) of the soil were   carried out to evaluate the effect on the bioassays. The principal   components analysis of the parameters determined by NMR, compositional   indexes, EC, TPH, and toxicology data shows that the first three   principal components accounted for the 78% of the total variance (40%,   25%, and 13% for the first, second, and third PC, respectively). A good   agreement was found between information obtained by compositional   indexes and NMR structural indexes. Soil toxicity increases with the   increase of EC and TPH. Other factors, such as, the presence of branched   and aromatic hydrocarbons is also significant. The statistical   evaluation showed that the Euclidean distances (3D) between the   background and each one of the samples might be a better indicator of   the soil contamination, compared with chemical criterion of TPH.","palabras_clave":"PETROLEUM|HYDROCARBON|SOIL|TOXICITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38135,"idioma_id":4,"titulo":"ATHEROPROTECTIVE REMODELING OF VASCULAR DERMATAN SULFATE PROTEOGLYCANS IN RESPONSE TO HYPERCHOLESTEROLEMIA IN A RAT MODEL","resumen":"          Proteoglycan accumulation within the arterial intima  has been implicated in atherosclerosis progression in humans. Nevertheless,  hypercholesterolemia is unable to induce intimal thickening and atheroma plaque  development in rats. The study was performed to analyze proteoglycans  modifications in rats fed with  a high-cholesterol diet, to understand whether vascular wall remodeling protects  against lesion. Sections obtained from rat aortas showed normal features, in intimal-to-media ratio and  lipid accumulation. However, focal endothelial hyperplasia and neointima  rearrangement were observed in high-cholesterol animals. Besides, hypercholesterolemia induced an  increase in tumor necrosis factor alpha messenger RNA. We also determined the  expression of different proteoglycans from aortic cells by Western blot and observed  a diminished expression of decorin and biglycan in high-cholesterol animals  compared with control (p&lt;  0.01and p&lt;0.05; respectively). Versican was increased in high-cholesterol animals (p&lt;0.05), whereas perlecan expression showed no  differences. No modification of the  total content of glycosaminoglycans was found between both experimental groups.  In contrast, the chondroitin sulfate \/dermatan sulfate ratio was increased in high-cholesterol  group as compared to control (0.56 and 0.34, respectively). Structural  alterations in the disaccharides composition of galactosaminoglycans were also detected  by HPLC, as the ratio of 6-sulfate to 4-sulfate disaccharides was increased in high-cholesterol animals (p&lt;  0.05). Our results suggest that attenuation of decorin and biglycan expression  might be an effective strategy to inhibit the first step in atherogenesis, although  specific glycosaminoglycan structural modification associated with the  development of vascular disease took place. Results emphasize the potential  application of therapies based on vascular matrix remodeling to treat  atherosclerosis.  ","palabras_clave":"ATHEROSCLEROSIS|AORTIC CELLS|EXTRACELLULAR MATRIX|PROTEOGLYCANS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38136,"idioma_id":4,"titulo":"- Molecular structures identified in serologically D negative samples of an admixed population","resumen":"BACKGROUND: The D negative phenotype is mainly caused by the complete  deletion of the RHD gene in Caucasians. However, a plethora of allelic variants  have been described among D negative individuals from different ethnic groups.  STUDY DESIGN AND METHODS: A cohort of 1314 routine serologically D  negative samples from white Argentineans was studied by molecular methods.  RESULTS: Among the 1314 D negative samples, 2.1% showed RHD-specific  amplifications. One hybrid Rhesus box was detected in all D negative\/RHD positive  samples suggesting a hemizygous status. The RHD&#936; was found in 0.7% of rr  samples while DEL and null variants were detected in 16.7% of the D negative  samples expressing C and\/or E antigens. The variants associated with the C  antigen were: 7 RHD-CE-Ds, 2 RHD(1-2)-CE(2-9)-D(10), 2 previously unreported  RHD(329T>C)-CE(3-9)-D null allele, 1 RHD(M295I) and 1 new RHCE(1-2)-  RHD(3361del11-10) null allele whereas those associated with the E antigen were: 5  RHD(46T>C) and 1 novel RHD(581insG) null allele responsible for a premature  stop codon.  CONCLUSIONS: The prevalence of D negative\/RHD positive samples is higher  than that observed in Europeans. More than 50% of the RHD alleles found were  represented by RHD&#968; and RHD-CE-Ds showing the African contribution to the  genetic pool of the admixed population analysed. Interestingly, three new alleles  were found, two of them being hybrid structures between previously described  RHD variants recombined with RHCE sequences. The knowledge of the RHD  allele repertoire in our population allowed the implementation of reliable typing and  transfusion strategies for a better management of patients and pregnant women.","palabras_clave":"D NEGATIVE|HYBRID GENES|RH SYSTEM|IMMUNOHEMATOLOGY|DEL ALLELES|NULL ALLELES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38137,"idioma_id":4,"titulo":"Different factors that modify anti-predator behaviour in guanacos (Lama guanicoe)","resumen":"Animals optimize the trade-off between the cost of  not fleeing and the benefits of staying because the factors that  influence flight decisions and the disturbance level of a particular  stimulus can vary both spatially and temporally.  Different factors (human impact and habitat characteristics)  likely to modify anti-predator behaviour in different types of  guanaco social groups were analysed. We found that group  size was conditioned by high poaching, vehicle traffic,   predation risk and vegetation density. Solitary adult males  showed shorter alert and flight initiation distances than bachelor  and mixed groups. Alert distance was greater during the  summer season, and assessment times were shorter when  young were present in the groups. In high-predation-risk  environments, guanacos detected threats at greater distances  and flight initiation distance was longer. Alert distances were  shorter on steeper sloped hills and assessment times were  shorter in areas with irregular topography than on flat sites.  In high traffic areas, flight initiation distance was longer and  assessment times were shorter. And in areas with low  poaching intensity, assessment times were greater than in  those with high poaching levels. Therefore, guanacos may  be able to evaluate a true threat. Social group and antipredator  responses were conditioned by habitat characteristics  and human impact. We consider that plasticity of responses  could be key to the survival of guanacos.","palabras_clave":"Behavioural reactions |Human disturbance|Predation risk|Social group"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38138,"idioma_id":4,"titulo":"Rheological properties of regular insulin and aspart insulin Langmuir monolayers at the air\/water interface: condensing effect of Zn2+ in the subphase","resumen":"The interfacial behavior of regular insulin (Reg-insulin) and aspart insulin (Asp-insulin) was critically affected by the presence of Zn2+ in the subphase.  This cation induced a condensed-like behavior in the compression isotherms, especially apparent for Reg-insulin films when observed by Brewster angle microscopy. Immediately after spreading, Reg-insulin, but not Asp-insulin, showed bright patches that moved in a gaseous-like state. Moreover, Zn2+ caused marked variations of the surface electrostatics of both insulin monolayers and considerable hysteresis of their molecular organization. By oscillatory compression-expansion cycles, we observed in all cases the development of a dilatational response to the surface perturbation, and both monolayers exhibited well-defined shear moduli in the presence of Zn2+, which was higher for Reg-insulin. Development of a shear modulus indicates behavior resembling a nominal solid, more apparent for Reg-insulin than for Asp-insulin, suggesting the presence of viscoelastic networks at the surface.","palabras_clave":"LANGMUIR MONOLAYERS|INSULIN|PROTEIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38139,"idioma_id":4,"titulo":"Incomplete sterols and hopanoids pathways in ciliates: Gene loss and acquisition during evolution as a source of biosynthetic genes","resumen":"Polycyclic triterpenoids, such as sterols and hopanoids, are essential components of plasmatic membrane in eukaryotic organisms. Although it is generally assumed that ciliates do not synthesize sterols, and many of them are indeed auxotrophic, a large set of annotated genomic sequences and experimental data from recently studied organisms indicate that they can carry putative genes and respond to the presence\/absence of precursors in various ways. The pre-squalene pathway, for instance, is largely present in all sequenced ciliates except in Ichthyophthirius multifiliis; although Paramecium tetraurelia lacks the squalene synthase and Oxytricha trifallax the squalene hopene synthase, in addition to the former. On the other hand, the post-squalene pathway, requiring oxygen in several steps, is mostly incomplete in all ciliates analyzed. Nevertheless, a number of predicted genes, with high sequence similarity to C-4 methyl oxidase\/s, C-14 demethylase, C-5 and C-7 desaturases and C-24 reductase of sterols are found in Tetrahymena and Paramecium, and scattered in other Stichotrichia ciliates. Moreover, several of these sequences are present in multiples paralogs, like the C-7 desaturase in Paramecium, that carries six versions of the only one present in Tetrahymena. The phylogenetic analyses suggest a mixed origin for the genes involved in the biosynthesis of sterols and surrogates in this phylum; while the genes encoding enzymes of the pre-squalene pathway are most likely of bacterial origin, those involved in the post-squalene pathway, including the processing of sterols obtained from the environment, may have been partially retained or acquired indistinctly from lower eukaryotes or prokaryotes. This particular combination of diverse gene\/s acquisition patterns allows for survival in conditions of poor oxygen availability, in which tetrahymanol and other hopanoids may be advantageous, but also conditions of excess oxygen availability and abundant sterols, in which the latter are preferentially phagocyte, and\/or transformed. Furthermore, the possibility that some of the genes involved in sterol metabolism may have another biological function in the most studied ciliate T. thermophila, was also explored","palabras_clave":"CILIATES|HGT|HOPANOIDS|TETRAHYMENA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38140,"idioma_id":4,"titulo":"First detection of CMY-2 plasmid mediated &#946;-lactamase in Salmonella Heidelberg in South America","resumen":"Salmonella enterica serovar Heidelberg ranks among the most prevalent causes of humansalmonellosis in the United States and Canada, although it has been infrequently reportedin South American and European countries. Most Salmonella infections are self-limiting;however, some invasive infections require antimicrobial therapy. In this work wecharacterized an oxyimino-cephalosporin resistant S. Heidelberg isolate recovered froman inpatient in a Buenos Aires hospital. CMY-2 was responsible for the &#946;-lactam resistanceprofi le. S. Heidelberg contained a 97 kb plasmid belonging to the Inc N group harboringblaCMY-2. ISEcp1 was located upstream blaCMY-2 driving its expression and mobilization. Theisolate belonged to sequence type 15 and virotyping revealed the presence of sopE gene.In this study we identifi ed the fi rst CMY-2 producing isolate of S. Heidelberg in Argentinaand even in South America.© 2013 Asociación Argentina","palabras_clave":"Salmonella Heidelberg |CMY-2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38141,"idioma_id":4,"titulo":"Coordination of plant mitochondrial biogenesis: keeping pace with cellular requirements","resumen":"Plant mitochondria are complex organelles that carry out numerous metabolic processes related with the generation of energy for cellular functions and the synthesis and degradation of several compounds. Mitochondria are semiautonomous and dynamic organelles changing in shape, number, and composition depending on tissue or developmental stage. The biogenesis of functional mitochondria requires the coordination of genes present both in the nucleus and the organelle. In addition, due to their central role, all processes held inside mitochondria must be finely coordinated with those in other organelles according to cellular demands. Coordination is achieved by transcriptional control of nuclear genes encoding mitochondrial proteins by specific transcription factors that recognize conserved elements in their promoter regions. In turn, the expression of most of these transcription factors is linked to developmental and environmental cues, according to the availability of nutrients, light?dark cycles, and warning signals generated in response to stress conditions. Among the signals impacting in the expression of nuclear genes, retrograde signals that originate inside mitochondria help to adjust mitochondrial biogenesis to organelle demands. Adding more complexity, several nuclear encoded proteins are dual localized to mitochondria and either chloroplasts or the nucleus. Dual targeting might establish a crosstalk between the nucleus and cell organelles to ensure a fine coordination of cellular activities. In this article, we discuss how the different levels of coordination of mitochondrial biogenesis interconnect to optimize the function of the organelle according to both internal and external demands.","palabras_clave":"mitochondrial dynamics| mitochondrial biogenesis|post-transcriptional gene regulation| site II"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38142,"idioma_id":4,"titulo":"Divergent functions of the Arabidopsis mitochondrial SCO proteins: HCC1 is essential for COX activity while HCC2 is involved in the UV-B stress response","resumen":"The two related putative cytochrome c oxidase (COX) assembly factors HCC1 and HCC2 from Arabidopsis thaliana are Homologs of the yeast Copper Chaperones Sco1p and Sco2p. The hcc1 null mutation was previously shown to be embryo lethal while the disruption of the HCC2 gene function had no obvious effect on plant development, but increased the expression of stress-responsive genes. Both HCC1 and HCC2 contain a thioredoxin domain, but only HCC1 carries a Cu-binding motif also found in Sco1p and Sco2p. In order to investigate the physiological implications suggested by this difference, various hcc1 and hcc2 mutants were generated and analyzed. The lethality of the hcc1 knockout mutation was rescued by complementation with the HCC1 gene under the control of the embryo-specific promoter ABSCISIC ACID INSENSITIVE 3. However, the complemented seedlings did not grow into mature plants, underscoring the general importance of HCC1 for plant growth. The HCC2 homolog was shown to localize to mitochondria like HCC1, yet the function of HCC2 is evidently different, because two hcc2 knockout lines developed normally and exhibited only mild growth suppression compared with the wild type (WT). However, hcc2 knockouts were more sensitive to UV-B treatment than the WT. Complementation of the hcc2 knockout with HCC2 rescued the UV-B-sensitive phenotype. In agreement with this, exposure of wild-type plants to UV-B led to an increase of HCC2 transcripts. In order to corroborate a function of HCC1 and HCC2 in COX biogenesis, COX activity of hcc1 and hcc2 mutants was compared. While the loss of HCC2 function had no significant effect on COX activity, the disruption of one HCC1 gene copy was enough to suppress respiration by more than half compared with the WT. Therefore, we conclude that HCC1 is essential for COX function, most likely by delivering Cu to the catalytic center. HCC2, on the other hand, seems to be involved directly or indirectly in UV-B-stress responses.","palabras_clave":"chaperona de cobre|citocromo oxidasa|mitocondria|biogénesis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38143,"idioma_id":4,"titulo":"Mitochondria and copper homeostasis in plants","resumen":"Copper (Cu) and other transition metals are essential for living   organisms but also toxic when present in excess. To cope with this   apparent paradox, organisms have developed sophisticated mechanisms to   acquire, transport and store these metals. Particularly, plant   mitochondria require Cu for the assembly and function of cytochrome c   oxidase (COX), the terminal enzyme of the respiratory chain. COX   assembly is a complex process that requires the action of multiple   factors, many of them involved in the delivery and insertion of Cu into   the enzyme. In this review, we summarize what is known about the   processes involved in Cu delivery to mitochondria and how these   processes impact in Cu homeostasis at the cellular level. We also   discuss evidence indicating that metallochaperones involved in COX   assembly play additional roles in signaling pathways related to changes   in Cu and redox homeostasis and the response of plants to stress. We   propose that cysteine-rich proteins present in the mitochondrial   intermembrane space are excellent candidates as sensors of these changes   and transducers of signals originated in the organelle to the rest of   the cell.","palabras_clave":"cobre|metalochaperona|mitocondria|biogénesis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38144,"idioma_id":4,"titulo":"Plant mitochondria under pathogen attack: A sigh of relief or a last breath?","resumen":"Plants constitute excellent sources for pathogen nutrition and survival.   To fight against pathogen attack, higher plants have developed a   sophisticated immune system responsible for pathogen recognition and   activation of downstream defense responses. After pathogen perception,   mitochondria play an important role in the defense strategy of the plant   cell, integrating and amplifying diverse signals such as salicylic   acid, nitric oxide, reactive oxygen species (ROS) or pathogen elicitors.   Signals perceived by mitochondria usually impact on their normal   function, destabilizing the organelle, generating changes in   respiration, membrane potential and ROS production. At this stage,   mitochondria produce several signals influencing the redox state of the   cell and promoting changes in the expression of nuclear genes by   mitochondrial retrograde regulation. At more advanced stages, they   promote programmed cell death in order to avoid pathogen propagation to   the whole plant. Recent evidence indicates that plants and pathogens   have evolved mechanisms to modulate the immune response by acting on   mitochondrial functions. In this review, we summarize knowledge about   the involvement of mitochondria in different aspects of the response of   plants to pathogen attack.","palabras_clave":"patógeno|mitocondria|defensa|inmunidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38145,"idioma_id":4,"titulo":"A new eilenodontine (Lepidosauria, Sphenodontidae) from the Lower Cretaceous of central Patagonia","resumen":"A new species of eilenodontine sphenodontian, Priosphenodon minimus, is described from a locality 400 km south of those that yield the northern Patagonian eilenodontines (the largest known terrestrial sphenodontians). The new species, represented by subadult specimens, is both the smallest known eilenodontine and the southern-most record of the group. Pr. minimus is characterized by a nearly vertical lateral process of the premaxilla; anteriorly extended frontals that lack the naso-prefrontal projections; a rounded frontal anterior process; a prefrontal that posteriorly embraces the nasal; a coronoid process of the dentary that is tall and with an anterior border that is vertical in medial view; strong anteromedial flanges on all teeth; uncommonly dense dental packing; and an anteriorly extended angular that reaches the midlength of the lower jaw. Differences from juvenile specimens of Priosphenodon avelasi, such as the interruption of the prefrontal-jugal contact, are marked. The holotype and associated material come from early Albian strata, and are therefore around 12 million years older than the northern Patagonian giant sphenodontians. The new species here described reveals that many of the characters used to diagnose Kaikaifilusaurus calvoi are widespread, so this taxon should be regarded as a nomen dubium. Therefore, the genus Priosphenodon is considered as valid herein, with the new species assigned to it. A phylogenetic analysis demonstrates the monophyly of  Priosphenodon and suggests that the new taxon represents an incidence of dwarfing. This discovery increases the morphological disparity among these specialized herbivores, and provides new climatological and biostratigraphic information on the terrestrial ecosystems of Patagonia.","palabras_clave":"Priosphenodon|dwarf|eilenodontine|Chubut Group"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38146,"idioma_id":4,"titulo":"Inter-hemispheric temperature variability over the past millennium","resumen":"of internal chaotic dynamics and natural and anthropogenic  external forcing. Recent instrumental data have shown a  remarkable degree of asynchronicity between Northern  Hemisphere and Southern Hemisphere temperature  fluctuations, thereby questioning the relative importance  of internal versus external drivers of past as well as future  climate variability. However, large-scale temperature  reconstructions for the past millennium have focused on the  Northern Hemisphere, limiting empirical assessments of  inter-hemispheric variability on multi-decadal to centennial  timescales. Here, we introduce a new millennial ensemble  reconstruction of annually resolved temperature variations for  the Southern Hemisphere based on an unprecedented network  of terrestrial and oceanic palaeoclimate proxy records. In  conjunction with an independent Northern Hemisphere  temperature reconstruction ensemble5, this record reveals an  extended cold period (1594-1677) in both hemispheres but  no globally coherent warm phase during the pre-industrial  (1000-1850) era. The current (post-1974) warm phase is the  only period of the past millennium where both hemispheres are  likely to have experienced contemporaneous warm extremes.  Our analysis of inter-hemispheric temperature variability  in an ensemble of climate model simulations for the past  millennium suggests that models tend to overemphasize  Northern Hemisphere?Southern Hemisphere synchronicity  by underestimating the role of internal ocean?atmosphere  dynamics, particularly in the ocean-dominated Southern  Hemisphere. Our results imply that climate system  predictability on decadal to century timescales may be  lower than expected based on assessments of external  climate forcing and Northern Hemisphere temperature  variations alone.","palabras_clave":"Inter-hemispheric climates|tree rings|paleoclimatology|Little Ice Age"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38147,"idioma_id":5,"titulo":"La escolaridad como hito en las biografías de los hijos de bolivianos en Buenos Aires","resumen":"Este trabajo se propone un dialogo entre tres trabajos de investigación  realizados desde perspectivas socio antropológicas aplicadas al análisis de las  experiencias de los hijos de inmigrantes bolivianos en distintos puntos de la Ciudad de Buenos Aires y la Provincia de Buenos Aires. A partir del estudio de los procesos migratorios desde Bolivia y de sus cambios a lo largo de las generaciones, pretendemos postular que la escolaridad constituye parte fundamental de la experiencia de los niños y jóvenes migrantes y muy especialmente de los descendientes de inmigrantes bolivianos.  Puesto que la misma afecta su formación intelectual, pero sobre todo, sus  identificaciones nacionales, étnicas, de género, de clase y particularmente de edad, nos enfocaremos en comprender el rol de la escolaridad en esa etapa vital considerada como juventud. Teniendo en cuenta algunas de las representaciones mas habituales en los casos examinados, expondremos que el paso por la escuela primaria y secundaria implica un hito en las biografías de los hijos de los bolivianos y los niños y jóvenes bolivianos que se han criado en Buenos Aires y analizaremos el impacto en sus formas de identificación y sus relaciones.","palabras_clave":"JUVENTUD|MIGRACION|BIOGRAFIAS|ESCOLARIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38148,"idioma_id":4,"titulo":"Slaughter weight, sex and age effects on beef shear force and tenderness","resumen":"In Argentina, beef cattle prices decrease as slaughter weight increases regardless of animal age or carcass maturity, and this decrease is significantly greater in heifers (15%) than in steers (5%). The objectives of the present study were to (1) determine whether shear force and tenderness differ between heifers of different slaughter weight, and between heifers, steers and cull cows of similar slaughter weight; (2) evaluate whether such differences, if any, could be overcome by extending beef aging period; and (3) understand the main causes of such differences in beef shear force and tenderness. Meat from heavy heifers (H-HEIFER, 381?420kg BW) was compared to meat from light heifers (L-HEIFER, 300?340kg BW), steers (STEER, 391?450kg BW) or cull cows of similar weight (COW). At slaughter, carcass characteristics were determined and Longissimus thoracis (LM) and Gluteus medius (GM) muscle samples collected for shear force determination. Total and insoluble collagen, sarcomere length and intact troponin-T content, and sensory panel scores, were evaluated for LM. Aging effect was evaluated for shear force and sensory panel scores. Irrespective of muscle or aging period, increasing heifer slaughter weight did not impact negatively on beef shear force or tenderness levels; heifers and steers of similar slaughter weight had similar beef shear force and tenderness levels; whereas heifer beef was more tender (P<0.05) than that from cow of similar slaughter weight. Tenderness differences were not overcome by extending the aging period. Based on a principal component analysis, shear force and tenderness differences appear to be associated to the variation in chilling rate and sarcomere length.","palabras_clave":"Shear force|Sensory panel|Aging|Chilling rate|Sarcomere length"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38149,"idioma_id":4,"titulo":"Antiproliferative and apoptosis-inducing activity of an oxidovanadium(IV) complex with the flavonoid silibinin against osteosarcoma cells","resumen":"Flavonoids are a large family of polyphenolic compounds synthesized by plants. Theydisplay interesting biological effects mainly related to their antioxidant properties. Onthe other hand, vanadium compounds also show different biological andpharmacological effects in cell culture and in animal models. Since coordination ofligands to metals can improve or change the pharmacological properties, we reportherein for the first time, a detailed study of the mechanisms of action of anoxovanadium(IV) complex with the flavonoid silibinin, Na2[VO(silibinin)2] 6H2O(VOsil) , in a model of human osteosarcoma derived cell line, MG-63. The complexinhibited the viability of the osteosarcoma cells in a dose dependent manner with agreater potency than silibinin and the oxovanadium(IV) (p&lt;0.01), demonstrating thebenefit of complexation. Cytotoxicity and genotoxicity studies also showed aconcentration effect for VOsil. The increment of reactive oxygen species (ROS) and thedecrease of the ratio GSH\/GSSG were involved in the deleterious effects of thecomplex. Besides, the complex caused cell cycle arrest and activated caspase 3,triggering apoptosis as determined by flow cytometry. As a whole, these results showedthe main mechanisms of the deleterious effects of VOsil in the osteosarcoma cell line,demonstrating that this complex is a promisory compound for cancer treatments.","palabras_clave":"ANTICANCER DRUG|MG-63 HUMAN OSTEOSARCOMA CELLS|MECHANISM OF ACTION|FLAVONOIDS|VANADIUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38150,"idioma_id":4,"titulo":"Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with Bovine Serum Albumin","resumen":"            A new chlorogenate oxidovanadium complex (Na[VO(chlorog)(H2O)3].4H2O)  was synthesised  by using Schlenk methodology in the course of a reaction  at inert atmosphere in which deprotonated chlorogenic acid ligand binds to oxidovanadium(IV)  in a reaction  experiment controlled via EPR  technique and based in a species distribution diagram. The compound was characterized  by FTIR, EPR, UV-vis and diffuse reflectance spectroscopies and thermogravimetric, differential thermal and elemental analysis. The  ligand and the complex were tested for their antioxidant effects on DPPH?, ABTS·+, O2?-, OH? and ROO?  radicals and their cytotoxic  activity on different cancer cell lines (SKBR3, T47D  and MDAMB231) and primary human mammary epithelial cells. The complex behaved as  good antioxidant agent with strongest inhibitory effects on O2?-,OH? and ROO? radicals and exhibited selective cytotoxicity against  SKBR3 cancer cells line. Albumin interaction experiments denoted high  affinity toward the complex and its calculated binding constant was indicative of  a strong binding to the protein. Based on this study, it is hypothesized that Na[VO(chlorog)(H2O)3].4H2O would be a&nbsp;  promising candidate for further evaluation as an antioxidant and  anticancer agent.   ","palabras_clave":"OXIDOVANADIUM(IV)|CHLOROGENIC ACID|ANTIOXIDANT ACTIVITY|ANTICANCER  ACTIVITY|ALBUMIN INTERACTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38151,"idioma_id":4,"titulo":"Age Determination of Fifteen Old to Intermediate-Age Small Magellanic Cloud  Star Clusters","resumen":"&nbsp;&nbsp;&nbsp; We present CMDs in the V and I bands for fifteen star clusters in the SmallMagellanic Cloud (SMC) based on data taken with the Very Large Telescope(VLT, Chile). We selected these clusters from our previous work (Parisi et al.2009), wherein we derived cluster velocities and metallicities from Calcium IIinfrared triplet (CaT) spectra also taken with the VLT. PSF photometry wasperformed on FORS2 preimaging exposures which were purposely lengthened inorder to obtain deep photometry to derive accurate ages. In the CMD of eachcluster we measured the &#948;V parameter and derived cluster ages using the cali-bration of Carraro &amp; Chiosi (1994) and Salaris et al. (2004). We found thatthe calibration of Salaris et al. (2004) tends to overestimate ages. The age dif-ference between these two calibrations increases for old clusters. We discoveredthat the ages of six of our clusters have been appreciably underestimated by pre-vious works, which used comparatively small telescopes, graphically illustratingthe need for large apertures to obtain reliable ages of old and intermediate-ageSMC star clusters. In particular, three of these clusters (L 4, L 6 and L 110), turnout to be amongst the oldest SMC clusters known. The determination of theirfundamental properties allow us to better trace the early chemical evolution ofthis galaxy. Using the calibration of Carraro &amp; Chiosi (1994), L 110, L 4 and L 6are 7.61 ± 1.03, 7.93 ± 1.07 and 8.71 ± 1.18 Gyr old, respectively, helping to fillthe ?SMC cluster age gap? (Glatt et al. 2008a). In order to corroborate the an-cient nature of these three clusters, we also calculated their ages from two otherindependent methods. First, we derived a new calibration using clusters studiedby Glatt et al. (2008a,b) using deep HST data, which can be considered the bestconstrained SMC cluster age calibration. Secondly, we fit theoretical isochronesto the CMD, inspired by the procedures of Glatt et al. (2008a,b). Both methodsconfirm that all three clusters are indeed very old. Finally, using ages from thecalibration of Carraro &amp; Chiosi (1994) and metallicities from (Parisi et al. 2009),we analyze the age distribution, age gradient and age metallicity relation (AMR)of a sample of SMC clusters measured homogeneously. There is a suggestion ofbimodality in the age distribution but it does not show a constant formation forthe first 4 Gyr (Piatti et al. 2011b), and we find no evidence for an age gradient.Due to the improved ages of our cluster sample, we find that our AMR is nowbetter represented in the intermediate\/old period than that we derived in Parisiet al. 2009, where we simply took ages available in the literature. Additionally,clusters younger than &#8764; 4 Gyr now maintain better agreement with the burst-ing model of Pagel &amp; Tautvai&#711;ien &#775; (1998), but we confirm that this model is&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; s enot a good representation of the AMR during the intermediate-age\/old period.A more complicated model is needed to explain the SMC chemical evolution inthat period.","palabras_clave":"clusters"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38152,"idioma_id":4,"titulo":"EVOLUTION AND DEVELOPMENT OF THE SPIKELET AND FLOWER OF RHYNCHOSPORA (CYPERACEAE)","resumen":"The flowermodifications and is one of a few genera where the pollination strategy changesfrom wind to insect pollination; however, the mechanisms that have promotedsuch diversity in the genus are unknown. We have performed a comparative studyof spikelet and flower development of Rhynchospora from an evolutionary perspectiveto get insight into the bases of spikelet and flower evolution. Particularly,we investigate correlations between the change from wind to insect pollinationthat occur in the genus and the spikelet and flower traits. Methodology.The spikelet and flower development of nine species of Rhynchospora werestudied using SEM images. Parsimony, maximum likelihood, and Bayesianreconstruction analyses were conducted to evaluate the evolutionary history offlower and spikelet developmental programs. Pivotal results. Weidentified seven morphological and developmental traits that vary among Rhynchosporaspecies; ancestral character reconstructions show that the spikelet andflower morphology and their developmental&nbsp;pathways support the diversification of Rhynchospora lineages. Conclusions.Our results suggest that the evolution of spikelet and flower developmentalprograms in Rhynchospora may be related to the evolution of itspollination type and mating system. The evolution toward a bisexual spikeletand flowers in which the androecium develops faster than the gynoecium mayrepresent important steps for the transition from a wind- to insect-pollinationsystem. In addition, we found new traits of spikelets and flowers that may helpto distinguish natural groups within Rhynchospora.","palabras_clave":"Evolucion|Desarrollo|Spikelet|Rhynchospora"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38153,"idioma_id":4,"titulo":"Fumarate\/ceramic composite based scaffolds for tissue engineering: evaluation of hydrophylicity, degradability, toxicity and biocompatibility","resumen":"The present study was designed to investigate the possible cytotoxicity and biocompatibility of scaffolds based on previously characterized polymeric materials including poly-&#61541;-caprolactone (PCL) or polydiisopropyl fumarate (blended or on their own), with or without hydroxyapatite (HAP). Water contact angle was also evaluated to determine the hydrophylicity of each scaffold. Degradation of different scaffolds was evaluated after a 10-week incubation in Dulbecco?s modi&#64257;ed eagle medium (DMEM) supplemented with 5% (v\/v) fetal bovine serum (FBS). Bone Marrow Stromal Cells (MSC) were grown on different scaffolds in an osteogenic medium, after which alkaline phosphatase activity (ALP) was evaluated. ALP activity increased when MSC were grown on PCL+HAP or Blend+HAP, as compared to PCL or Blend without HAP. The effect of different scaffolds on the proliferation of the macrophage cell line RAW 264.7, production of nitric oxide (NO) and secretion of pro-inflammatory cytokines was examined. After 72h, macrophages proliferated equally well on all scaffolds, maintaining a rounded morphology. None of the investigated scaffolds induced production of NO or cytokine release into the culture media, suggesting an absence of cytotoxicity. Therefore, these polymer- and HAP-based scaffolds could potentially be used as bone substitute materials.","palabras_clave":"Ingenieria de Tejido Oseo|Biomateriales|citotoxicidad|biocompatibilidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38154,"idioma_id":4,"titulo":"Anatomical analysis of the lizard carpal bones in the terms of skilled manual abilities","resumen":"One of the most remarkable hand movements is grasping. This ability has been repetitively associated with the evolution of the human lineage towards the development of technology. Besides mammals, other tetrapods have also evolved significant, and in some cases surprising, forelimb prehensile capabilities. In this study, we present a qualitative analysis of the carpal bones in diverse lizard taxa.  Our main goal is to make a survey of the carpal morphology of different squamatans and to interpret its variability in the context of both lizard skilled forelimb movements and the evolutionary history of Squamata.","palabras_clave":"CARPUS|LIZARDS|GRASPING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38155,"idioma_id":4,"titulo":"Fibrillar organization in tendons: A pattern revealed by percolation characteristics of the respective geometric network","resumen":"Since the tendon is composed by collagen fibrils of various sizes connected between them through molecular  cross-links, it sounds logical to model it via a heterogeneous network of fibrils. Using cross sectional images,  that network is operatively inferred from the respective Gabriel graph of the fibril mass centers. We focus on  network percolation characteristics under an ordered activation of fibrils (progressive recruitment going from  the smallest to the largest fibril). Analyses of percolation were carried out on a repository of images of digital  flexor tendons obtained from samples of lizards and frogs. Observed percolation thresholds were compared  against values derived from hypothetical scenarios of random activation of nodes. Strikingly, we found a  significant delay for the occurrence of percolation in actual data. We interpret this finding as the consequence  of some non-random packing of fibrillar units into a size-constrained geometric pattern. We erect an ideal  geometric model of balanced interspersion of polymorphic units that accounts for the delayed percolating  instance. We also address the circumstance of being percolation curves mirrored by the empirical curves of  stress-strain obtained from the same studied tendons. By virtue of this isomorphism, we hypothesize that the  inflection points of both curves are different quantitative manifestations of a common transitional process  during mechanical load transference.","palabras_clave":"percolation|collagen|fibril network|interspersion|pattern recognition"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38156,"idioma_id":4,"titulo":"Layer-by-Layer Assembly of Polymersomes and Polyelectrolytes on Planar Surfaces and Microsized Colloidal Particles","resumen":"Hybrid polyelectrolyte multilayer systems were fabricated on top of planar surfaces and colloidal particles via layer by layer (LbL) assembly of polystyrene sulfonate (PSS) and polybenzyl methacrylate-block-poly(dimethylamino)ethyl methacrylate (PBzMA-b-PDMAEMA) polymersomes. Polymersomes were prepared by self assembly of PBzMA-b-PDMAEMA copolymer, synthesised by group transfer polymerisation. Polymersomes display a diameter of 270 nm and a shell thickness of 11 nm. Assembly on planar surfaces was followed by means of the Quartz Crystal Microbalance with Dissipation (QCM-D) and Atomic Force Microscopy (AFM). Detailed information on the assembly mechanism and surface topology of the polymersome\/polyelectrolyte films was thereby obtained. The assembly of polymersomes and PSS on top of silica particles of 500 nm in diameter was confirmed by &#950;?potential measurements. Confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that polymersome\/PSS coated silica particles increase in total diameter up to 3-5 &#956;m. This hints toward the formation of densely packed polymersome layers. In addition, CLSM showed that polymersome\/PSS films exhibit a high loading capacity that could potentially be used for encapsulation and delivery of diverse chemical species. These results provide an insight into the formation of multilayered films with compartmentalised hydrophilic\/hydrophobic domains and may lead to the successful application of polymersomes in surface-engineered colloidal systems.","palabras_clave":"Layer by layer assembly|Polymersomes|Supramolecular Assembly|Polymer thin films"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38157,"idioma_id":4,"titulo":"Circadian oscillation and development-dependent expression of Glycine Rich RNA Binding Proteins in tomato fruits","resumen":"                              Glycine-rich RNA-binding proteins (GRPs) are involved in RNA metabolism, modulating the posttranscriptional  processing of transcripts; and have been suggested as an output signal of the circadian  clock. However, neither GRPs nor the circadian rhythmic have been studied in  detail in fleshy fruits yet. In the present work, grp1 gene family was analyzed in Micro-Tom tomato fruit.  Three highly homologous Legrp1 genes (Legrp1a-c) were identified. For each gene, three transcriptional products  were found, which correspond to the un-spliced pre-RNA, the mature mRNA and the  alternatively spliced mRNA (preLegrp1a-c,  mLegrp1a-c and asLegrp1a-c, respectively). LeGRPs show the  classical N-terminal end RNA recognition motif and  the C-terminal end glycine-rich region and were found  in the nucleus and in the cytosol of tomato fruit. All  LeGRP1s complemented the cold-sensitive phenotype of Escherichia coli mutant BX04 cells under cold stress, and harbored  in vivo RNA-melting abilities. The levels of all transcriptional forms of Legrp1a-c and the total immunoreactive  LeGRP1 decrease during tomato fruit development. Here is shown for the first  time particular circadian profiles of expression for each transcriptional Legrp1 form, which are fruit developmental  stage dependent, with  the green stages independent of plant signals.  During  ripening off the vine of fruits harvested at the mature green stage, the levels  of all transcriptional forms of Legrp1a-c  drastically increased; however, incubation at 4ºC prevented such increases. Correlation  analysis of the expression of all Legrp1a-c  transcriptional forms suggests a positive regulation of expression in  tomato fruit. Overall, the results  obtained in this work reveal a complex pattern of expression of GRPs in tomato  fruit suggesting they might be involved in posttranscriptional modulation of circadian  processes of this fleshy fruit.                                                                                                                                                                  ","palabras_clave":"Solanum lycopersicon|Glycin rich protein|tomato|ARN-binding"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38158,"idioma_id":4,"titulo":"Deciphering the mechanisms involved in Portulaca oleracea (C4) response to drought: metabolic changes including crassulacean acid-like metabolism induction and reversal upon re-watering","resumen":"Portulaca oleracea is a C4 plant; however, under drought it can change itscarbon fixation metabolism into a crassulacean acid metabolism (CAM)-likeone. While the C3-CAM shift is well known, the C4-CAM transition has onlybeen described in Portulaca. Here, a CAM-like metabolism was inducedin P. oleracea by drought and then reversed by re-watering. Physiologicaland biochemical approaches were undertaken to evaluate the drought andrecovery responses. In CAM-like plants, chlorophyll fluorescence parameterswere transitory affected and non-radiative energy dissipation mechanismswere induced. Induction of flavonoids, betalains and antioxidant machinerymay be involved in photosynthetic machinery protection. Metabolic analysishighlights a clear metabolic shift, when a CAM-like metabolism is inducedand then reversed. Increases in nitrogenous compounds like free amino acidsand urea, and of pinitol could contribute to withstand drought. Reciprocalvariations in arginase and urease in drought-stressed and in re-watered plantssuggest urea synthesis is strictly regulated. Recovery of C4 metabolism wasaccounted by CO2 assimilation pattern andmalate levels. Increases in glyceroland in polyamines would be of importance of re-watered plants. Collectively,in P. oleracea multiple strategies, from induction of several metabolites to thetransitory development of a CAM-like metabolism, participate to enhance itsadaptation to drought.","palabras_clave":"PORTULACA OLERACEA|DROUGHT|UREA|REWATERING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38159,"idioma_id":4,"titulo":"Allantoin catabolism influences the production of antibiotics in Streptomyces coelicolor","resumen":"Purines are a primary source of carbon and nitrogen  in soil; however, their metabolism is poorly understood in  Streptomyces. Using a combination of proteomics, metabolomics,  and metabolic engineering, we characterized the allantoin  pathway in Streptomyces coelicolor. When cells grew in  glucose minimal medium with allantoin as the sole nitrogen  source, quantitative proteomics identified 38 enzymes upregulated  and 28 downregulated. This allowed identifying six  new functional enzymes involved in allantoin metabolism in  S. coelicolor. Fromthose, using a combination of biochemical  and genetic engineering tools, it was found that allantoinase  (EC 3.5.2.5) and allantoicase (EC 3.5.3.4) are essential for  allantoin metabolism in S. coelicolor. Metabolomics showed  that under these growth conditions, there is a significant  intracellular accumulation of urea and amino acids, which  eventually results in urea and ammonium release into the  culture medium. Antibiotic production of a urease mutant  strain showed that the catabolism of allantoin, and the subsequent  release of ammonium, inhibits antibiotic production.  These observations link the antibiotic production impairment  with an imbalance in nitrogen metabolism and provide the  first evidence of an interaction between purine metabolism  and antibiotic biosynthesis.","palabras_clave":"Allantoina|Streptomyces coelicolor|catabolismo|antibióticos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38160,"idioma_id":4,"titulo":"Settlement of Gracilaria gracilis carpospores (Gracilariales, Rhodophyta) on natural substrates from the southwestern Atlantic coast (Chubut, Argentina)","resumen":"Gracilaria gracilis is an important agarophyte  that is exploited in Argentina by the harvest of detached  thalli cast on the shore. Therefore, the study of carpospores  is relevant because such spores can be used as inoculum  for commercial aquaculture. In this study, the potential  of two natural substrates from the Patagonian coast, for  the settlement and growth of G. gracilis carpospores, was  evaluated in the laboratory. Highly significant differences  were found between substrates both in the proportion  of substrates with settled spores and in carpospore density,  shells being more suitable than pebbles. Regarding  carposporeling growth, differences in sporeling length  between substrates could not be detected by the end of the  study, although basal discs reached a significantly higher  diameter on pebbles than on shells. Results indicate that  shells would be a good substrate to start spore culture  because they offer a suitable surface for spore settlement.  In addition, if the substrate is inoculated with sufficient  seedling material to avoid competition among individuals  and, if epiphytism is successfully reduced, sporelings  should reach the required size for transport to the natural  environment.","palabras_clave":"CARPOSPORES|GRACILARIA GRACILIS|SPORE CULTURE|SUBSTRATES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38161,"idioma_id":4,"titulo":"Synthesis of triaryls: Hydroxy and amine dinaphthyl and diphenanthryl aryls by one-pot electron-transfer nucleophilic substitution reactions","resumen":"A new one-pot synthetic route to achieve the preparation of hydroxy and   amine binaphthyl and biphenanthryl aryls is here reported. This approach   involves the reaction of 1,4-bromoiodobenzene, 4,4&#8242;-diiodobiphenyl, and   1,4- and 1,5-diiodonaphthalene with the anions of 2-naphthylamine,   2-naphthol, and 9-phenanthrylamine under irradiation in liquid ammonia.   The reactions proceed to afford triaryl derivatives in moderate to good   yields (&#8764;45% of 1,4-phenylene- and   1,4-naphthylene-1,1&#8242;-dinaphthalen-2-ols as well as   1,4-phenylene-1,1&#8242;-dinaphthalen-2-amine and   10,10&#8242;-diphenanthren-9-amine). Lower yields (27%) of polyaryl   derivatives are obtained by reaction of 4,4&#8242;-diiodobiphenyl with anions   of 2-naphthol and 9-phenanthrylamine.","palabras_clave":"poliarilos|SRN1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38162,"idioma_id":4,"titulo":"Downregulation of the ACE2\/ Ang-(1-7)\/Mas axis in transgenic mice overexpressing GH","resumen":"The renin-angiotensin system (RAS) plays a crucial role in the regulation of physiological homeostasis and diseases such as hypertension, coronary artery disease, and chronic renal failure. In this cascade, the angiotensin-converting enzyme (ACE)\/angiotensin II (Ang II)\/AT1 receptor axis induces pathological effects, such as vasoconstriction, cell proliferation, and fibrosis, while the ACE2\/Ang-(1-7)\/Mas receptor axis is protective for end-organ damage. The altered function of the RAS could be a contributing factor to the cardiac and renal alterations induced by GH excess. To further explore this issue, we evaluated the consequences of chronic GH exposure on the in vivo levels of Ang II, Ang-(1-7), ACE, ACE2, and Mas receptor in the heart and the kidney of GH-transgenic mice (bovine GH (bGH) mice). At the age of 7-8 months, female bGH mice displayed increased systolic blood pressure (SBP), a high degree of both cardiac and renal fibrosis, as well as increased levels of markers of tubular and glomerular damage. Angiotensinogen abundance was increased in the liver and the heart of bGH mice, along with a concomitant increase in cardiac Ang II levels. Importantly, the levels of ACE2, Ang-(1-7), and Mas receptor were markedly decreased in both tissues. In addition, Ang-(1-7) administration reduced SBP to control values in GH-transgenic mice, indicating that the ACE2\/Ang-(1-7)\/Mas axis is involved in GH-mediated hypertension. The data indicate that the altered expression profile of the ACE2\/Ang-(1-7)\/Mas axis in the heart and the kidney of bGH mice could contribute to the increased incidence of hypertension, cardiovascular, and renal alterations observed in these animals.","palabras_clave":"Angiotensin|ACE|Mouse"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38163,"idioma_id":4,"titulo":"Muckenhoupt weights with singularities on closed lower dimensional sets in spaces of homogeneous type","resumen":"We give sufficient conditions on a real number eta and on a closed set F in a general space of homogeneous type (X,d,mu) in such a way that mu(B(x,d(x,F)))^beta becomes a Muckenhoupt weight. In order to prove our result, we modify the underlying space so that it becomes 1-Ahlfors regular.","palabras_clave":"MUCKENHOUPT|SPACES|AHLFORS|MAXIMAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38164,"idioma_id":4,"titulo":"Characterization of the Na+\/HCO3- cotransport in human neutrophils","resumen":"Bicarbonate transport has crucial roles in regulating intracellular pH (pHi) in a variety of cells. The purpose of this study was to evaluate its participation in the regulation of pHi in resting and stimulated human neutrophils. We demonstrated that resting neutrophils have a bicarbonate transport mechanism that prevents acidification when the Na+\/H+ exchanger is blocked by EIPA. Neutrophils acidified by an ammonium prepulse showed an EIPA-resistant recovery of pHi that was inhibited by the blocker of the anionic transporters SITS or the Na+\/HCO3- cotransporter (NBC) selective inhibitor S0859, and abolished when sodium was removed from the extracellular medium. In western blot and RT-PCR analysis the expression of NBCe2 but not NBCe1 or NBCn1 was detected in neutrophils isolated membranes. Acidified neutrophils increased the EIPA-insensitive pHi recovery rate when its activity was stimulated with fMLF\/cytochalasin B. This increase in the removal of acid equivalents was insensitive to the blockade of the NADPH oxidase with DPI. It is concluded that neutrophils have an NBC that regulates basal pHi and is modulated by chemotactic agents.","palabras_clave":"Neutrophils|NBC|bicarbonate|sodium"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38165,"idioma_id":4,"titulo":"Consequences of Volcanic Ash Deposition on the Locomotor Performance of the Phymaturus spectabilis Lizard from Patagonia, Argentina","resumen":"The locomotor performance of lizards depends on their morphological and physiological adaptations to the habitat. However, when the habitat changes dramatically, for example, by a volcanic eruption, the performance of lizards may be affected. We registered the vegetation cover, the surface covered by ash, the presence of crevices suitable for Phymaturus and the rocks slopes to analyze the effects of ash ccumulation produced by the eruption of Puyehue &#8208; Cordon Caulle volcanic complex on microhabitat use and availability of the Phymaturus spectabilis lizard. In addition, we studied the effect of ashes and slope on the locomotor performance of P. spectabilis by registering the maximum speed in sprint runs and long runs under four different treatments (cork and on the level, ashes and on the level, cork and slope, and ashes and slope). P. spectabilis selected microhabitats unvegetated, with crevices and steep slopes. Regarding locomotor performance, the speed of lizards was negatively affected by the presence of ash only in sprint runs on the level and in long runs with slope. The slope had a negative impact on the speed in all the treatments. These results show that the presence of volcanic ashes in the substrate might have affected the locomotor performance of the lizards, especially in long runs, and hence, the interaction of individuals with the environment, that is, escaping from predators and social behavior.","palabras_clave":"locomotion|microhabitat|rock-dwelling lizards|volcanic eruption"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38166,"idioma_id":4,"titulo":"Altered Lipid Homeostasis in Sertoli Cells Stressed by Mild Hyperthermia","resumen":"Spermatogenesis is known to be vulnerable to temperature. Exposures of rat testis to moderate hyperthermia result in loss of germ cells with survival of Sertoli cells (SC). Because SC provide structural and metabolic support to germ cells, our aim was to test the hypothesis that these exposures affect SC functions, thus contributing to germ cell damage. In vivo, regularly repeated exposures (one of 15 min per day, once a day during 5 days) of rat testes to 43°C led to accumulation of neutral lipids. This SC-specific lipid function took 1-2 weeks after the last of these exposures to be maximal. In cultured SC, similar daily exposures for 15 min to 43°C resulted in significant increase in triacylglycerol levels and accumulation of lipid droplets. After incubations with [3H]arachidonate, the labeling of cardiolipin decreased more than that of other lipid classes. Another specifically mitochondrial lipid metabolic function, fatty acid oxidation, also declined. These lipid changes suggested that temperature affects SC mitochondrial physiology, which was confirmed by significantly increased degrees of membrane depolarization and ROS production. This concurred with reduced expression of two SC-specific proteins, transferrin, and Wilms´ Tumor 1 protein, markers of SC secretion and differentiation functions, respectively, and with an intense SC cytoskeletal perturbation, evident by loss of microtubule network (&#945;-tubulin) and microfilament (f-actin) organization. Albeit temporary and potentially reversible, hyperthermia-induced SC structural and metabolic alterations may be long-lasting and\/or extensive enough to respond for the decreased survival of the germ cells they normally foster.","palabras_clave":"SERTOLI CELLS|HYPERTHERMIA|LIPID DROPLETS|ARACHIDONIC ACID"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38167,"idioma_id":4,"titulo":"Another one bites the dust: Bite force and ecology in three caviomorph rodents (Rodentia, Hystricognathi)","resumen":"Mammals have developed sophisticated strategies adapting to particular locomotor modes, feeding habits, and social interactions.Many rodent species have acquired a fossorial, semi&#8208;fossorial, or even subterranean life&#8208;style, converging on morphological, anatomical, and ecological features but diverging in the final arrangement. These ecological variations partially depend on the functional morphology of their digging tools. Muscular and mechanical features (e.g., lever arms relationship) of the bite force were analyzed in three caviomorph rodents with similar body size but different habits and ecological demands of the jaws. In vivo forces were measured at incisors' tip using a strain gauge load cell force transducer whereas theoretical maximal performance values, mechanical advantages, and particular contribution of each adductor muscle were estimated fromdissections in specimens of Ctenomys australis (subterranean, solitary), Octodon degus (semi&#8208;fossorial, social), and Chinchilla laniger (ground&#8208;dweller, colonial). Our results showed that C. australis bites stronger than expected given its small size and C. laniger exhibited the opposite outcome, while O. degus is close to the expected value based on mammalian bite force versus body mass regressions; what might be associated to the chisel&#8208;tooth digging behavior and social interactions. Our key finding was that no matter how diverse these rodents' skulls were, no difference was found in the mechanical advantage of the main adductor muscles. Therefore, interspecific differences in the bite force might be primarily due to differences in the muscular development and force, as shown for the subterranean, solitary and territorial C. australis versus the more gracile, ground&#8208;dweller, and colonial C. laniger.","palabras_clave":"BITE FORCE|BEHAVIOR|CHINCHILLA LANIGER|CTENOMYS AUSTRALIS|FUNCTIONAL MORPHOLOGY|OCTODON DEGUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38168,"idioma_id":4,"titulo":"Postnatal ontogeny of limb proportions and functional indices in the subterranean rodent Ctenomys talarum (Rodentia: Ctenomyidae)","resumen":"Burrow construction in the subterranean Ctenomys talarum (Rodentia: Ctenomyidae) primarily occurs by scratch-digging. In this study, we compared the limbs of an ontogenetic series of C. talarum to identify variation in bony elements related to fossorial habits using a morphometrical and biomechanical approach. Diameters and functional lengths of long bones were measured and 10 functional indices were constructed. We found that limb proportions of C. talarum undergo significant changes throughout postnatal ontogeny, and no significant differences between sexes were observed. Five of six forelimb indices and two of four hindlimb indices showed differences between ages. According to discriminant analysis, the indices that contributed most to discrimination among age groups were robustness of the humerus and ulna, relative epicondylar width, crural and brachial indices, and index of fossorial ability (IFA). Particularly, pups could be differentiated from juveniles and adults by more robust humeri and ulnae, wider epicondyles, longer middle limb elements, and a proportionally shorter olecranon. Greater robustness indicated a possible compensation for lower bone stiffness while wider epicondyles may be associated to improved effective forces in those muscles that originate onto them, compensating the lower muscular development. The gradual increase in the IFA suggested a gradual enhancement in the scratch-digging performance due to an improvement in the mechanical advantage of forearm extensors. Middle limb indices were higher in pups than in juveniles?adults, reflecting relatively more gracile limbs in their middle segments, which is in accordance with their incipient fossorial ability. In sum, our results show that in C. talarum some scratch-digging adaptations are already present during early postnatal ontogeny, which suggests that they are prenatally shaped, and other traits develop progressively. The role of early digging behavior as a factor influencing on morphology development is discussed.","palabras_clave":"ECOMORPHOLOGY|FUNCTIONAL MORPHOLOGY|LIMB'S DEVELOPMENT|SCRATCH-DIGGING|FOSSORIAL ADAPTATIONS|TUCO-TUCOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38169,"idioma_id":4,"titulo":"Estimation of primary production in the southern Argentine continental shelf and shelf-break regions using field and remote sensing data","resumen":"The Argentine continental shelf and shelf-break regions comprise a large and rich biological area of the ocean. However, field estimations of primary production are scarce, making remote sensing of ocean color a valuable tool to provide synopticmaps of primary production in this ecologically relevant region. Field studies performed during spring 2005, and summer and winter 2006 showed a high spatial and seasonal variability in the daily integrated water column primary production, chlorophyll-a and biomass-normalized photosynthetic parameters. Using field measurements, five different and relatively simple (non-spectral and vertically homogeneous biomass) models were tested: three chlorophyll-, one carbon- and one absorption-based model. The chlorophyllbased?BIOM?model developed by Platt and Sathyendranath (Science, 241:1613?1620, 1988) provided the closest estimates to the field values, and was selected as the local algorithm. Its performance was assessed using simultaneous satellite-derived products and field photosynthetic parameters as input. Close values compared to the field estimates were obtained using BIOM (Absolute Percent Difference error, APD ~10%), even though satellite-derived products used as input to the model (i.e. chlorophyll-a concentration, diffuse attenuation coefficient in the photosynthetically active radiation range ? PAR-, and PAR irradiance) showed relative high errors (APD ~40%, 20% and 50%, respectively). Provided that an efficientway to assign the physiological parameters in a pixel-by-pixel basis is found, this model seems to be the best to produce primary production maps from remote sensing of ocean color in the southern Argentine shelf and shelf-break regions.","palabras_clave":"Primary production|Model|Remote sensing|Ocean Color|Argentine Sea"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38170,"idioma_id":4,"titulo":"Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models","resumen":"Purpose: Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults. Chemotherapy with temozolomide (TMZ) significantly prolongs the survival of GBM patients. However, the 3-year survival is still ~5%. Herein we combined intratumoral administration of an adenoviral vector expressing Flt3L (Ad-Flt3L) with systemic TMZ in order to assess its impact on therapeutic efficacy.   Experimental Design: Wild type or immunodeficient mice bearing intracranial GBM or  metastatic melanoma were treated with an intratumoral injection of Ad-Flt3L alone or in combination with the conditionally cytotoxic enzyme thymidine kinase (Ad-TK), followed by systemic administration of ganciclovir and TMZ. We monitored survival and measured the tumor-infiltrating immune cells.  Results: While treatment with TMZ alone led to a small improvement in median survival, when used in combination with gene therapy-mediated immunotherapy it significantly increased the survival of tumor-bearing mice. The anti-tumor effect was further enhanced by concomitant intratumoral administration of Ad-TK, leading to 50-70% long-term survival in all tumor models. Although TMZ reduced the content of T cells in the tumor, this did not affect the therapeutic efficacy. The anti-tumor effect of Ad-Flt3L+Ad-TK+TMZ required an intact immune system, since the treatment failed when administered to KO mice that lacked lymphocytes or dendritic cells.   Conclusions: Our results challenge the notion that chemotherapy leads to a state of immune-suppression which impairs the ability of the immune system to mount an effective anti-tumor response. Our work indicates that TMZ does not inhibit antitumor immunity and supports its clinical implementation in combination with immune-mediated therapies.","palabras_clave":"GLIOBLASTOMA|GENE THERAPY|TEMOZOLOMIDE|IMMUNOTHERAPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38171,"idioma_id":4,"titulo":"Epidemics in Partially Overlapped Multiplex Networks","resumen":"Many real networks exhibit a layered structure in which links in each layer reflect the function of nodes on different environments. These multiple types of links are usually represented by a multiplex network in which each layer has a different topology. In real-world networks, however, not all nodes are present on every layer. To generate a more realistic scenario, we use a generalized multiplex network and assume that only a fraction q of the nodes are shared by the layers.  We develop a theoretical framework for a branching process to describe the spread of an epidemic on these partially overlapped multiplex networks. This allows us to obtain the fraction of infected individuals as a function of the effective probability that the disease will be transmitted T. We also theoretically determine the dependence of the epidemic threshold on the fraction q of shared nodes in a system composed of two layers. We find that in the limit of q->0 the threshold is dominated by the layer with the smaller isolated threshold. Although a system of two completely isolated networks is nearly indistinguishable from a system of two networks that share just a few nodes, we find that the presence of these few shared nodes causes the epidemic threshold of the isolated network with the lower propagating capacity to change discontinuously and to acquire the threshold of the other network.","palabras_clave":"Complex Networks|Epidemic Models"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38172,"idioma_id":4,"titulo":"Metabolic level recognition of progesterone in dairy Holstein cows using probabilistic models","resumen":"Administration of exogenous progesterone is widely used in hormonal protocols for estrous (re)synchronization of dairy cattle without regarding pharmacological issues for dose calculation. This happens because it is difficult to estimate the metabolic level of progesterone for each individual cow before administration. In the present contribution, progesterone pharmacokinetics has been determined in lactating Holstein cows with different milk production yields. A Bayesian approach has been implemented to build two probabilistic progesterone pharmacokinetic models for high and low yield dairy cows. Such models are based on a one-compartment Hill structure. Posterior probabilistic models have been structurally set up and parametric probability density functions have been empirically estimated. Moreover, a global sensitivity analysis has been done to know sensitivity profile of each model. Finally, posterior probabilistic models have adequately recognized cow´s progesterone metabolic level in a validation set when Kullback-Leibler based indices were used. These results suggest that milk yield may be a good index for estimating pharmacokinetic level of progesterone.","palabras_clave":"progesterone pharmacokinetic|Hill equation|metabolism|milk yield|Bayesian modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38173,"idioma_id":4,"titulo":"IL-15 controls T cell functions through its influence on CD30 and OX40 Antigens in Celiac Disease","resumen":"AIM:               To evaluate the ability of interleukin (IL)-15 to   control T cell functions through its influence on CD30 and OX40   expressing cells in Celiac Disease (CD). In peripheral blood (PB), by   examining the expression of OX40 in conventional effectors cells and T   cells with a phenotypic specialization of regulatory cells   [CD4(+)CD25(high) forkhead box protein 3 (Foxp3)(+)], and the co   stimulation of IFN-&#947; and IL-4 production within CD30 and OX40 positive   subsets of T cells. At the duodenal mucosa, by assessing the expression   of CD30 and OX40 in intraepithelial (IE) and lamina propria (LP)   lymphocytes (IEL, LPL).              PATIENTS AND METHODS:               PB and   duodenal mucosal biopsies were obtained from 38 patients with classic CD   (Cel) and 38 healthy controls (HC). Analysis of cell surface and\/or   intracellular antigens was performed in anti-CD3-treated PB mononuclear   cells (PBMC) before and after treatment with recombinant IL-15 (rIL-15),   and in IE and LP cellular suspensions prepared from duodenal biopsies   pre-treated with\/without rIL-15.              RESULTS:               A subpopulation   of CD3(+)OX40(+) T blasts was induced in Cel and HC by a 3days   treatment of PBMC with anti-CD3 and decreased its size thereafter,   regardless of the presence of rIL-15. However, the addition of rIL-15 to   T blasts distinctively induced the survival of T cells with a   regulatory phenotype that expresses OX40 antigen in Cel (p&lt;0.05).   Celiac patients showed higher frequencies of IFN-&#947;-producing   CD3(+)CD30(+) blasts before and after treatment with rIL-15 (p&lt;0.05,   vs. HC). IL-15 increased the frequencies of CD3(+)CD30(+) LPL (HC:   p&lt;0.05, Cel: p&lt;0.05) but not of CD3(+)OX40(+) LPL, and CD30 or   OX40 positive IEL.              CONCLUSIONS:               The distinctive control   of OX40(+) cells with a T regulatory phenotype mediated by the influence   of IL-15 comes out as new function of this cytokine in the context of   CD. The higher production of IFN-&#947; by a subpopulation of peripheral   CD3(+)CD30(+) cells contributes to the type I biased immune response.","palabras_clave":"Interleukin-15|CD30|OX40|CELIAC DISEASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38174,"idioma_id":4,"titulo":"Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage","resumen":"Amyloid precursor protein (APP) shedding yields the Alzheimer?s disease (AD)-related peptide amyloid b (Ab) through b- and g-secretase cleavage. Alternatively, a-secretase cleavage generates a soluble and neuroprotective fragment (sAPPa) while precludes the production of Ab. Although metabotropic glutamate (mGlu) receptors were associated with induction of sAPPa production in astrocytes, there was no further evidence regarding the specific subtype receptor or the mechanisms involved in this action. In the present study, we used the dual mGlu2\/3 receptor agonist LY379268, which in pure astrocyte cultures selectively activates mGlu3 receptor subtype since mGlu2 receptor subtype is not expressed by these cells. We showed that LY379268 incremented sAPPa release from cultured astrocytes by inducing asecretases expression, whereas it decreased b-secretase levels. LY379268-induced increase of PPAR-g levels could be involved in the effect of the agonist on sAPPa release. Using the PDAPP-J20 murine model of AD we described a strong reduction in mGlu2\/3 receptor expression in the hippocampus of 5- and 14-month-old transgenic mice compared to control littermates. Moreover, mGlu3 receptor expression is also  decreased specifically in hippocampal astrocytes of these transgenic animals as a function of age. Therefore, diminished levels of hippocampal mGlu3 receptors might have implications in the development of the disease in these transgenic mice considering the anti-amyloidogenic action of mGlu3 receptors  in astrocytes.","palabras_clave":"metabotropic receptors|alpha-secretase|amyloid beta|astrocytes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38175,"idioma_id":4,"titulo":"SURVIVAL AND BENEFICIAL PROPERTIES OF LACTIC ACID BACTERIA FROM RANICULTURE SUBJECTED TO FREEZE-DRYING AND STORAGE","resumen":"Aim: To evaluate the effect of freeze-drying and storage conditions on the viability and beneficial properties of lactic acid bacteria (LAB) for raniculture.Methods and Results: Lactococcus lactis CRL 1584, L. lactis CRL 1827,Lactococcus garvieae CRL 1828 and Lactobacillus plantarum CRL 1606 viability under different conditions was studied. 10% lactose and 5% skim milk + 5%lactose were excellent lyoprotectants, but 5% skim milk + 5% lactose and whey protein concentrated (WPC) or WPC + sugars were the lower cost lyoprotective options. The effect of temperature depended on both lyoprotectants and storage time. Thus, for Lactococcus, skim milk, skim milk + sucrose and WPC + sucrose were selected for lyophilization and storage at 4°C and skim milk + lactose for 25°C. For Lact. plantarum CRL 1606, the best lyoprotectants for lyophilization and storage at 4°C were milk + sugars and WPS + sucrose and, at 25°C, skim milk + sucrose.Conclusions: Lactic acid bacteria viability after freeze-drying was strain specific and depended on the lyoprotectant used. Highest viability was obtained when stored at 4°C, and the beneficial properties remained stable for 18 months independently of storage temperature.Significance and Impact of the Study: The studies reported for the first time in this work are of primary interest to obtain dried bacteria to be included in beneficial products for raniculture.","palabras_clave":"LACTIC ACID BACTERIA|LIOPHYLIZATION|PROBIOTICS|RANICULTURE|STORAGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38176,"idioma_id":4,"titulo":"The signaling pathway for aldosterone-induced mitochondrial production of superoxide anion in the myocardium","resumen":"Mineralocorticoid receptor (MR) antagonists decrease morbidity and mortality in heartfailure patients for whom oxidative stress is usual; however, the underlying mechanism for this protection is unclear. Since aldosterone stimulates reactive oxygen species (ROS) production in several tissues, we explored its effect and the intracellular pathway involved in the rat myocardium. Aldosterone dose-dependently increased O2 .- production in myocardial slices. At 10 nmol\/L, aldosterone increased O2 .- to 165±8.8 % of control, effect prevented not only by the MR antagonists eplerenone and spironolactone (107±7.8 and 103±5.3 %, respectively) but also by AG1478 (105±8.0%), antagonist of the EGF receptor (EGFR). Similar results were obtained by silencing MR expression through the direct intramyocardial injection of a lentivirus coding for a siRNA against the MR. The aldosterone effect on O2 .- production was mimicked by the mKATP channel opener diazoxide and blocked by preventing its opening with 5-HD and glibenclamide, implicating the mitochondria as the source for O2 .- . Inhibiting the respiratory chain with rotenone or mitochondrial permeability transition (MPT) with cyclosporine A or bongkrekic acid also cancelled aldosterone-induced O2 .- production. In addition, aldosterone effect depended on NADPH oxidase and phosphoinositide 3- kinase activation, as apocynin and wortmannin, respectively, inhibited it. EGF (0.1&#956;g\/mL) similarly increased O2 .-, although in this case MR antagonists had no effect, suggesting that EGFR transactivation occurred downstream from MR. Inhibition of mKATP channels, the respiratory chain, or MPT did not prevent Akt phosphorylation, supporting it happened upstream of the mitochondria. Importantly, cardiomyocytes were confirmed as source of aldosterone induced mitochondrial ROS production in experiments performed in isolated cardiac myocytes. These results allow us to speculate that the beneficial effects of MR antagonists in heart failure may be related to a decrease in oxidative stress.","palabras_clave":"Aldosterone |superoxide|mitochondria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38177,"idioma_id":4,"titulo":"A gene-derived SNP-based high resolution linkage map of carrot including the location of QTL conditioning root and leaf anthocyanin pigmentation","resumen":"Background: Purple carrots accumulate large quantities of anthocyanins in their roots and leaves. These flavonoid pigments possess antioxidant activity and are implicated in providing health benefits. Informative, saturated linkage maps associated with well characterized populations segregating for anthocyanin pigmentation have not been developed. To investigate the genetic architecture conditioning anthocyanin pigmentation we scored root color visually, quantified root anthocyanin pigments by high performance liquid chromatography in segregating F2, F3 and F4 generations of a mapping population, mapped quantitative trait loci (QTL) onto a dense gene-derived single nucleotide polymorphism (SNP)-based linkage map, and performed comparative trait mapping with two unrelated populations.Results: Root pigmentation, scored visually as presence or absence of purple coloration, segregated in a pattern consistent with a two gene model in an F2, and progeny testing of F3-F4 families confirmed the proposed genetic model. Purple petiole pigmentation was conditioned by a single dominant gene that co-segregates with one of the genes conditioning root pigmentation. Root total pigment estimate (RTPE) was scored as the percentage of the root with purple color. All five anthocyanin glycosides previously reported in carrot, as well as RTPE, varied quantitatively in the F2 population. For the purpose of QTL analysis, a high resolution gene-derived SNP-based linkage map of carrot was constructed with 894 markers covering 635.1 cM with a 1.3 cM map resolution. A total of 15 significant QTL for all anthocyanin pigments and for RTPE mapped to six chromosomes. Eight QTL with the largest phenotypic effects mapped to two regions of chromosome 3 with co-localized QTL for several anthocyanin glycosides and for RTPE. A single dominant gene conditioning anthocyanin acylation was identified and mapped.Comparative mapping with two other carrot populations segregating for purple color indicated that carrot anthocyanin pigmentation is controlled by at least three genes, in contrast to monogenic control reported previously.Conclusions: This study generated the first high resolution gene-derived SNP-based linkage map in the Apiaceae. Two regions of chromosome 3 with co-localized QTL for all anthocyanin pigments and for RTPE, largely condition anthocyanin accumulation in carrot roots and leaves. Loci controlling root and petiole anthocyanin pigmentation differ across diverse carrot genetic backgrounds.","palabras_clave":"Carrot|anthocyanins|QTL mapping|linkage map"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38178,"idioma_id":4,"titulo":"A non-singlet oxygen mediated reaction photoinduced by phenalenone, a universal reference for singlet oxygen sensitization","resumen":"Photosensitized oxidations involve the generation of radicals (type I mechanism) and\/or the production of singlet molecular oxygen (1O2) (type II mechanism). Phenalenone (PN) is one of the well-known type II photosensitizers and is widely used as a 1O2 reference sensitizer. In this work, we have studied the interaction of tryptophan (Trp) with the excited states of PN, the production of 1O2 in the presence of Trp, the formation of radicals and the kinetics of the photodegradation of Trp under different experimental conditions. In contrast to what is usually assumed, we have proven that PN is also able to act as a type I photosensitizer. Moreover, we have demonstrated that the predominant mechanism of the photosensitization of Trp by PN involves an electron transfer initiated-process.","palabras_clave":"singlet oxygen|electron transfer|phenalenone|tryptophan"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38179,"idioma_id":4,"titulo":"Possible chromospheric activity cycles in AD Leo","resumen":"AD Leo (GJ 388) is an active dM3 flare star that has been extensively observed both in the quiescent and flaring states. Since this active star is near the fully convective boundary, studying its long-term chromospheric activity in detail could be an appreciable contribution to dynamo theory. Here, using the Lomb-Scargle periodogram, we analyze the Ca II K line-core fluxes derived from CASLEO spectra obtained between 2001 and 2013 and the V magnitude from the ASAS database between 2004 and 2010. From both of these totally independent time series, we obtain a possible activity cycle with a period of approximately seven years and a less significant shorter cycle of approximately two years. A tentative interpretation is that a dynamo operating near the surface could be generating the longer cycle, while a second dynamo operating in the deep convection zone could be responsible for the shorter one. Based on the long duration of our observing program at CASLEO and the fact that we observe different spectral features simultaneously, we also analyze the relation between simultaneous measurements of the Na I index (R´_D), Halfa, and Ca II K fluxes at different activity levels of AD Leo, including flares.","palabras_clave":"Stars: low-mass|Stars: activity|Stars: flare"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38180,"idioma_id":4,"titulo":"Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep","resumen":"The flukicidal compound triclabendazole (TCBZ) has a complex metabolic pattern that includes the systemicpresence of its sulphoxide (TCBZ.SO) and sulphone (TCBZ.SO2) metabolites, usually recovered fromthe bile of treated animals. The aim of the current work was to evaluate the time-course and pattern ofin vivo accumulation of TCBZ\/metabolites into adult Fasciola hepatica specimens recovered from infectedsheep. Twelve (12) healthy Corriedale sheep were orally infected with one hundred (100) metacercariaeof the TCBZ-susceptible Cullomptom isolate of F. hepatica. Sixteen weeks after infection, animals wereintraruminally treated with TCBZ (10 mg\/kg). At 3, 24, 48 and 60 h post-treatment (pt), animals were sacrificed(n = 3\/time period) and samples of blood, bile, liver tissue and adult F. hepatica specimens werecollected. The concentrations of TCBZ\/metabolites were measured by HPLC. TCBZ.SO and TCBZ.SO2 werethe only molecules recovered in the bloodstream, with peak plasma concentrations of 10.8 lg\/mL(TCBZ.SO) and 12.6 lg\/mL (TCBZ.SO2). The same metabolites were also the main analytes accumulatedwithin the adult flukes, reaching peak concentrations between 6.35 lg\/g (TCBZ.SO) and 13.9 lg\/g(TCBZ.SO2) at 24 h pt, which was coincident with the time when the maximum plasma concentrationwas attained. Low levels of TCBZ parent drug (0.14 lg\/g at 24 h pt) were measured within collectedflukes. TCBZ parent drug and its sulpho- and hydroxy-derivatives were recovered in bile collected fromtreated sheep between 3 and 60 h pt. Although relatively high concentrations of hydroxy-TCBZ (rangingfrom 0.86 to 10.1 lg\/mL) were measured in bile, this metabolite was not recovered within the flukes atany time pt. Finally, TCBZ parent drug was the main compound accumulated in liver tissue over the 60 hpt period. The time-course and drug concentration patterns within the adult liver fluke after TCBZ treatmentfollowed a similar trend to those observed in plasma. Overall, the data reported here confirm thatoral ingestion is a main route of drug entry into the trematode in vivo exposed to TCBZ\/metabolites.","palabras_clave":"TRICLABENDAZOLE|FASCIOLA HEPATICA|OVINOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38181,"idioma_id":4,"titulo":"Evaluation of pharmacological interactions after administration of a levamisole, albendazole and ivermectin triple combination in lambs","resumen":"The goals of the current trial were (a) to characterize the plasma disposition kinetics oflevamisole (LEV), albendazole (ABZ) and ivermectin (IVM), each administered either alone(single active ingredient) or as a combined formulation to lambs; (b) to compare the clinicalanthelmintic efficacy of the same drugs given either separately or co-administered to lambsinfected with resistant nematodes. Fifty Corriedale lambs naturally infected with multipleresistant gastrointestinal nematodes were involved in the following experimental trials:(a) ?Pharmacokinetic trial?: the animals were allocated into five groups (n = 10 each) andintraruminally treated with either LEV (8 mg\/kg), ABZ (5 mg\/kg), IVM (0.2 mg\/kg), or with aLEV + ABZ + IVM combined formulation, where each active ingredient was administered atthe same dose. Blood samples were collected over 15 days post-treatment and drug plasmaconcentrations measured by HPLC. (b) ?Efficacy trial?: the same treated groups plus anuntreated control group were used to assess the comparative anthelmintic efficacy by thefaecal egg count reduction test (FECRT). Although the overall LEV disposition kinetics wasunaffected, significantly lower (61%) ABZ-sulphoxide and higher (71%) IVM systemic availabilitieswere obtained after administration of the combined formulation in comparison tothose obtained after treatment with each drug alone. A multiple drug resistance situationwas observed for Haemonchus spp. The observed efficacies were 52% (LEV), 72% (ABZ), 80%(IVM) and 87% (triple combined formulation). The results reported here contribute to thepharmaco-therapeutic knowledge on drug combinations. This type of research is crucialbefore further development of combined anthelmintic preparations reaches the marketto deal with resistant nematode control. The co-administration of LEV + ABZ + IVM did notresult in a significant advantageous anthelmintic effect compared to the treatment with IVMalone. The simultaneous\/combined administration of LEV, ABZ and IVM may account for adrug?drug pharmacological interaction in infected lambs. The pharmacokinetic interactionaccounted for a reduced ABZ-sulphoxide and enhanced IVM systemic exposure followingthe combined treatment.","palabras_clave":"ALBENDAZOLE|LEVAMISOL|IVERMECTINA|COMBINACIONES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38182,"idioma_id":4,"titulo":"Exploring the Potential of Flubendazole in Filariasis Control: Evaluation of the Systemic Exposure for Different Pharmaceutical Preparations","resumen":"Elimination or eradication of human filariases will almost certainly require the use of a macrofilaricidal agent. In vivo trials in humans and many experimental animal models suggest that flubendazole (FLBZ) is a highly efficacious macrofilaricide. However, since serious injection site reactions were reported in humans after parenteral FLBZ administration, the search for alternative pharmaceutical strategies to improve the systemic availability of FLBZ and its metabolites has acquired urgency in both human and veterinary medicine. The goal of the current work was to compare the systemic exposure of FLBZ formulated as either an aqueous hydroxypropyl-&#946;-cyclodextrin (CD) or aqueous carboxymethyl cellulose (CMC) suspension or a Tween 80-based formulation (TWEEN) in rats and jirds (Meriones unguiculatus). Healthy animals of both species were allocated into four experimental groups of 44 animals each. Treatment was as follows: FLBZ-CDoral and FLBZ-CDsc, in which animals were treated with the FLBZ-CD formulation by the oral or subcutaneous routes, respectively; FLBZ-TWEENsc, in which animals were dosed subcutaneously with the FLBZ-TWEEN formulation; and FLBZ-CMCoral, in which animals were dosed orally with the FLBZ suspension. The FLBZ dose was 5 mg\/kg.   FLBZ and its hydrolyzed (H-FLBZ) and reduced (R-FLBZ) metabolites were recovered in plasma samples collected from rats and jirds treated with the different FLBZ formulations. In both species, FLBZ parent drug was the main analyte recovered in the bloodstream. In rats, FLBZ systemic exposure (evaluated as area under the plasma concentration vs. time curve, AUC0-LOQ) was significantly (P < 0.05) higher after the FLBZ-CD treatments, both oral (4.8 ± 0.9 µg.h\/mL) and subcutaneous (7.3 ± 0.6 µg.h\/mL), compared to that observed after oral administration of FLBZ-CMC suspension (0.93 ± 0.2 µg.h\/mL). The same differences with respect to drug formulations were observed in jirds. In both species, parenteral administration of FLBZ-TWEEN did not improve the systemic availability of FLBZ compared to FLBZ-CDoral treatment. In conclusion, FLBZ\/metabolite systemic exposure may be markedly improved by changes in pharmaceutical formulation, which may have a great impact on its clinical efficacy against adult filarial parasites.","palabras_clave":"FLUBENDAZOLE|FILARIASIS|CYCLODEXTRINS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38183,"idioma_id":4,"titulo":"COMPOSITION, IN VITRO ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF ESSENTIAL OIL AND OLEORESINS OBTAINED FROM BLACK CUMIN SEEDS (NIGELLA SATIVA L.)","resumen":"Gas chromatography-mass spectrometry (GC-MS) analysis revealed the major components in black cumin essential oils which were thymoquinone (37.6%) followed by p-cymene (31.2%), alpha-thujene (5.6%), thymohydroquinone (3.4%), and longifolene (2.0%), whereas the oleoresins extracted in different solvents contain linoleic acid as amajor component.The antioxidant activity of essential oil and oleoresins was evaluated against linseed oil system at 200 ppm concentration by peroxide value, thiobarbituric acid value, ferric thiocyanate, ferrous ion chelating activity, and 1,1-diphenyl-2-picrylhydrazyl radical scavenging methods. The essential oil and ethyl acetate oleoresin were found to be better than synthetic antioxidants.The total phenol contents (gallic acid equivalents, mg GAE per g) in black cumin essential oil, ethyl acetate, ethanol, and n-hexane oleoresinswere calculated as 11.47±0.05, 10.88±0.9,9.68 ± 0.06, and 8.33 ± 0.01, respectively, by Folin-Ciocalteaumethod. The essential oil showed up to 90%zone inhibition againstFusarium moniliforme in inverted petri plate method. Using agar well diffusion method for evaluating antibacterial activity, theessential oil was found to be highly effective against Gram-positive bacteria.","palabras_clave":"BLACK CUMIN SEEDS|ESSENTIAL OIL|OLEORESINS |ANTIMICROBIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38184,"idioma_id":4,"titulo":"Ontogeny and total sugar content of yacon tuberous roots and other three Smallanthus species (Heliantheae, Asteraceae), insights on the development of a semi-domesticated crop","resumen":"The ontogeny of the tuberous roots of yacon (Smallanthus sonchifolius), an ancient Andean crop, is described for the first time along with three  other wild species of Smallanthus: S. connatus, S. macroscyphus and S. siegesbeckius. Tuberous storage roots are present in the four species. Tuberization results from unusual secondary thickening. A meristematic endodermis maintains the primary cortex by generating cortex cells continuously. Secretory schizogenous canals develop adjacent to the endodermis in opposition to the phloem poles. Phellogen originates in the outer layers of the parenchymatic cortex. The four species develop a parenchymatous pith that stores mainly fructooligosacharides (FOS) and plays an important role in storing water, protectingthe plant from drought stress and environmental hazards in the Andean climate. In yacon, domestication has produced a wide pith that stores water, reducing sugars and FOS with low degree of polimerization, that could have eventually made it more palatable as compared to the wild counterparts.","palabras_clave":"FRUCTOOLIGOSACCHARIDES|ONTOGENY|ROOT ANATOMY|SMALLANTHUS SONCHIFOLIUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38185,"idioma_id":4,"titulo":"SYNTHESIS, CRYSTAL STRUCTURE, CONFORMATIONAL AND VIBRATIONAL PROPERTIES OF 6- ACETYL-2,2-DIMETHYL-CHROMANE","resumen":"The 6-acetyl-2,2-dimethyl-chromane compound was synthesized and characterized by IR, Raman, UV-Visible and 1H NMR spectroscopies. Its solid state structure was determined by X-ray diffraction methods. The substance crystallizes in the triclinic P-1 space group with a = 5.9622(5) Å, b = 10.342(1) Å, c = 10.464(1) Å, &#945; = 63.81(1)°, &#946; = 81.923(9)°, &#947; = 82.645(9)°, and Z = 2 molecules per unit cell. Due to extended &#960;-bonding delocalization a substantial skeletal fragment of the molecule is planar. The vibrational modes were calculated at B3LYP\/6 31G(d,p) level   and all of them assigned in the IR and Raman spectra. The DFT calculated 1H NMR spectrum (chemical shifts) were in good  agreement with the experimental data. The electronic (UV-Visible) spectrum was calculated using TDDFT method in gas phase and it was correlated with the experimental data. The assignment and  analysis of the frontier HOMO and LUMO orbitals indicate that the absorption bands are mainly originated from &#960; &#8594; &#960;* transitions. According to DSC measurements the substance presents a melting point of 93 ºC and decomposes at temperatures higher than 196 ºC.","palabras_clave":"6-ACETYL-2,2-DIMETHYL-CHROMANE|DFT CALCULATIONS|IR AND RAMAN SPECTROSCOPY|X-RAY CRYSTAL STRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38186,"idioma_id":4,"titulo":"Alteration of the microRNA-122 regulatory network in rat models of hepatotoxicity","resumen":"MicroRNAs are small RNA molecules that post-transcriptionally regulate gene expression. MicroRNA-122 is the most abundant and specific liver microRNA. Hepatotoxicity involves a significant alteration of liver gene expression. The aim of this work was to evaluate the microRNA-122 regulatory network in models of hepatotoxicity induced by thioacetamide or carbon tetrachloride. We report that the toxins decreased the expression of microRNA-122, which corresponded with an increase in two target genes: Cyclin G1 and the cationic amino acid transporter CAT-1. We found a decreased expression of its precursor, pri-microRNA-122, and of the transcription factors that specifically bind its promoter: CCAAT\/enhancer-binding protein alpha, and members of the hepatocyte nuclear factor family. Therefore, microRNA-122 expression levels are under transcriptional control during hepatotoxicity. We propose that the changes observed are associated with the liver response to cope with the injury caused by the hepatotoxins, likely through a cell proliferation process to repair the damaged tissue.","palabras_clave":"Hepatotoxicity|miR122|microRNA|Liver"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38187,"idioma_id":4,"titulo":"A phylogenetic study of subtribe Otachyriinae (Poaceae, Panicoideae, Paspaleae)","resumen":"The subtribe Otachyriinae was established, within tribe Paniceae, by Butzin in 1970,  originally including 18 genera. Recent phylogenetic studies, based on molecular data,  indicated that Otachyriinae belongs to tribe Paspaleae and is represented by the  genera Anthaenantia, Hymenachne, Dallwatsonia, Otachyrium, species of Panicum  sect. Laxa, Plagiantha, and Steinchisma. These taxa show a peculiar diversity in  photosynthetic types, including C4 species, C3-C4 intermediates and C3 species. The  internal evolutionary relationships among members of Otachyriinae have not yet been  explored in detail. With the aim of providing new evidence to understand phylogenetic  relationships of taxa included in Otachyriinae, 21 new sequences of the ndhF gene  from 34 species were generated and analyzed using Bayesian inference (BI) and  maximum parsimony (MP). The evolution of photosynthetic pathway was studied  employing MP, Markov chain Monte Carlo (MCMC), and Maximum likelihood (ML)  methods. Our results confirm that subtribe Otachyriinae is monophyletic. Within the  subtribe, Anthaenanthia is a monophyletic C4 genus and is sister to the remaining  species included in this treatment. Hymenachne and Panicum sect. Laxa, in its  traditional concept, are polyphyletic; Dallwatsonia, P. auritum, and P. hemitomon are  treated within Hymenachne while three species of Panicum sect. Laxa are considered  a new genus in the subtribe. The genus Otachyrium is paraphyletic, while all species of  Steinchisma are recovered as a monophyletic group with high support. Finally, our  data suggest that C4 and C3-C4 photosynthesis evolved just once each during the  speciation of the subtribe from a C3 ancestor.","palabras_clave":"POACEAE|OTACHYRIINAE|C4 PHOTOSYNTESIS|PHYLOGENY|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38188,"idioma_id":4,"titulo":"On the Investigation of the Droplet-Droplet AOT Reverse Micellar Interaction upon Changing the External Solvent Composition and, its Impact on Gold Nanoparticles Synthesis","resumen":"The effect of the composition of the nonpolar  organic media on the 1,4-bis-2-ethylhexylsulfosuccinate (AOT) reverse micelles  (RMs) properties at a fixed temperature were investigated. To monitor  interfacial micropolarity and sequestrated water structure in n-heptane:benzene\/AOT\/water RMs, the solvatochromic  behavior of coumarin 343 (C343) as absorption and emission probe was studied while the droplet sizes, were measured by dynamic  light scattering (DLS).    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; DLS  results confirm the formation of the n-heptane:benzene\/AOT\/water  RMs at every n-heptane mole fraction  investigated. The data show that as the n-heptane  content increases, the inter-droplet attractive interactions and the droplet  sizes also increases. With C343 spectroscopy we were able to determine the  ?operational? critical micellar concentration, the RMs interfacial  micropolarity, the hydrogen bond ability of the media and the sequestrated  water structure in every RMs studied.     &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; To verify the modulation of the inter-droplet interactions  by the external solvent we have used a well-known synthetic method to create gold nanoparticles in different RMs media. The results support the conclusions that using n-heptane  as a nonpolar solvent the droplet-droplet interactions are favored. Thus, the rate of material exchange among micelles increases,  and hence, small, monodispersed and highly concentrated gold nanoparticles are formed. The situation is different for AOT RMs  prepared in benzene where subnanometer gold clusters are produced. The formation of clusters  instead of nanoparticles reflects a poor material exchange among micelles due to unfavorable droplet-droplet  interactions. In this  way, our results offer a new appealing way to focus the production of  nanoparticles into sub-nanometer clusters, which is one of the hottest topics  nowadays in nanoparticle synthesis.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Therefore,  it is possible to dramatically affect different RMs properties by changing the  solvent blend, which cannot be obtained using only single solvent composition,  and which may have a high impact on nanotechnology. We  anticipate remarkable effect on nanoparticle  sizes and polydispersity when working with different organic solvent blend  composition.","palabras_clave":"NANOSCIENCE|NANOPARTICLES|REVERSE MICELLES|AOT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38189,"idioma_id":4,"titulo":"Supramolecular Assemblies Obtained by Mixing Different  Cyclodextrins and AOT or BHDC Reverse Micelles","resumen":"Ver copia pdf","palabras_clave":"REVERSE MICELLES|MODIFIED CYCLODEXTRINS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38190,"idioma_id":4,"titulo":"'FoxO3a modulation and promotion of apoptosis by interferon-&#945;2b in rat  preneoplastic liver?.","resumen":"Background  FoxO3a, a member of the FOXO family of transcription factors, is expressed in adult liver and modulates the expression of genes involved in apoptosis. FoxO3a is post-translationally regulated, negatively by PI3K\/Akt and MAPK\/Erk and positively by oxidative stress\/JNK pathways. In previous works, we have demonstrated that interferon-alpha2b (IFN-alpha2b) induces apoptosis of hepatic preneoplastic foci through the production of reactive oxygen species (ROS).    Aims  To investigate the post-translational signal events triggered by the oxidative stress induced by IFN-alpha2b and the modulation of FoxO3a transcriptional activity during these events in rat preneoplastic liver.    Methods  Adult male Wistar rats were subjected to a two-phase model of hepatocarcinogenesis. A group of animals received IFN-alpha2b and another group received IFN-alpha2b and ascorbic acid (ASC), by intraperitoneal injection. Lipid peroxidation, immunohistochemistry, immunoblotting, co-immunoprecipitation and sqRT-PCR assays were performed to explore the role of ROS, JNK, Akt, Erk, FoxO3a, beta-catenin and PUMA in the IFN-alpha2b-mediated apoptotic mechanism.    Results  In vivo IFN-alpha2b treatment induced endogenous production of ROS which activated JNK. IFN-alpha2b blocked the activation of Akt and Erk, avoiding FoxO3a activity repression. Activated JNK was responsible for the nuclear translocation and transcriptional activity of FoxO3a which positively modulated the expression of PUMA, a proapoptotic player. In addition, nuclear FoxO3a competed for the nuclear beta-catenin associated to TCF, inhibiting the canonical Wnt signalling pathway.    Conclusions  The data presented here propose a model in which in vivo IFN-alpha2b treatment induces nuclear translocation and transcriptional activity of FoxO3a, triggering the mitochondrial apoptotic pathway in hepatic preneoplastic foci.AfrikaansAlbanianArabicArmenianAzerbaijaniBasqueBelarusianBulgarianCatalanChinese (Simplified)Chinese (Traditional)CroatianCzechDanishDetect languageDutchEnglishEstonianFilipinoFinnishFrenchGalicianGeorgianGermanGreekHaitian CreoleHebrewHindiHungarianIcelandicIndonesianIrishItalianJapaneseKoreanLatinLatvianLithuanianMacedonianMalayMalteseNorwegianPersianPolishPortugueseRomanianRussianSerbianSlovakSlovenianSpanishSwahiliSwedishThaiTurkishUkrainianUrduVietnameseWelshYiddish&#8644;AfrikaansAlbanianArabicArmenianAzerbaijaniBasqueBelarusianBulgarianCatalanChinese (Simplified)Chinese (Traditional)CroatianCzechDanishDutchEnglishEstonianFilipinoFinnishFrenchGalicianGeorgianGermanGreekHaitian CreoleHebrewHindiHungarianIcelandicIndonesianIrishItalianJapaneseKoreanLatinLatvianLithuanianMacedonianMalayMalteseNorwegianPersianPolishPortugueseRomanianRussianSerbianSlovakSlovenianSpanishSwahiliSwedishThaiTurkishUkrainianUrduVietnameseWelshYiddishDetect language » Hungarian","palabras_clave":"MAPK|PUMA|HEPATOCARCINOGENESIS|OXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38191,"idioma_id":5,"titulo":"El significado de las fórmulas químicas para estudiantes universitarios. El lenguaje químico como instrumento para la construcción de conocimiento","resumen":"In this work we decided to investigate the impact of the chemical language in previous knowledge of a central theme of organic chemistry, structure and reactivity of benzene. We designed a task with open and closed questions to study different aspects of this theme. Students spontaneously resorted to formulas to answer open questions, so it evidenced its use as a cognitive amplifier. It was also found that symbolic level conditioned submicroscopic interpretation. However, formulas did not become an instrument of thought given students? limitations in predicting reactivity. These results permit us to raise again the starting point for planning teaching and reflect on the importance of the chemical language appropriation when learning science.","palabras_clave":"CHEMICAL LANGUAGE|ORGANIC CHEMISTRY|UNIVERSITY|LEARNING|CHEMICAL KNOWLEDGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38192,"idioma_id":4,"titulo":"Role of mitochondria during female gametophyte development and fertilization in A. thaliana","resumen":"Plants alternate between two generations during their life cycle: the diploid sporophyte and the haploid male and female gametophytes, in which gametes are generated. In higher plants, the female gametophyte or embryo sac is a highly polarized seven-celled structure that develops within the sporophytic tissues of the ovule. It has been proposed that mitochondria are crucial in many cell signaling pathways controlling mitosis, cell specification, cell death and fertilization within the embryo sac. Here, we summarize recent findings that highlight the importance of this organelle during female gametophyte development and fertilization in plants.","palabras_clave":"PLANT MITOCHONDRIA|FEMALE GAMETOPHYTE|SIGNALING|REACTIVE OXYGEN SPECIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38193,"idioma_id":4,"titulo":"A tool for detecting transient faults in execution of parallel scientific  applications on multicore clusters","resumen":"Transient faults are  becoming a critical concern among current trends of design of general-purpose  multiprocessors. Because of their capability to corrupt programs outputs, their  impact gains importance when considering long duration, parallel scientific  applications, due to the high cost of re-launching execution from the beginning  in case of incorrect results. This paper introduces SMCV tool which improves  reliability for high-performance systems. SMCV replicates application processes  and validates the contents of the messages to be sent, preventing the  propagation of errors to other processes and restricting detection latency and  notification. To assess its utility, the overhead of SMCV tool is evaluated  with three computationally-intensive, representative parallel scientific applications.  The obtained results demonstrate the efficiency of SMCV tool to detect  transient faults occurrences","palabras_clave":"TRANSIENT FAULT|PARALLEL SCIENTIFIC APPLICATION|SOFT ERROR DETECTION TOOL|MESSAGE CONTENT VALIDATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38194,"idioma_id":4,"titulo":"'Maternal sucrose-rich diet and fetal programming: changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis in adult offspring.'","resumen":"Nutritional insults during pregnancy and lactation (P+L) are often associated with offspring health risks. We investigated the effect of maternal exposure to a sucrose-rich diet (SRD) during P+L on glucose and lipid metabolism of adult offspring regardless of post-weaning diet. Dams were fed an SRD or a control diet (CD) during P+L. After weaning, male offspring from SRD and CD dams were divided in two groups and fed a CD or SRD until 150-days old forming CD-CD, CD-SRD, SRD-SRD and SRD-CD groups. Offspring where SRD was fed at any period of life showed: 1) Increased adipose tissue weight without changes in final body weight; 2) Dyslipidemia as result of increased very low density lipoprotein triglyceride secretion rate and decreased triglyceride clearance; 3) Hepatic steatosis associated with increased activity of key enzymes involved in liver de novo lipogenesis and significant decrease of the activity of mitochondrial fatty acid oxidation enzyme. These results were more pronounced in CDSRD and SRD-SRD groups. 4) Hyperglycemia without changes in insulin levels, plus a deterioration of intravenous glucose tolerance and intraperitoneal insulin tolerance test. We hypothesized that SRD during P+L could be associated with a programming effect  on glucose homeostasis and hepatic lipid metabolism that predispose offspring to develop later-life insulin resistance and metabolic disorders, regardless of post-natal diet. Journal of citation of citation Reports Thomson reuters: IF: 2.694. Paper aceptado (10-12-13) y en prensa.","palabras_clave":"SUCROSE-RICH DIET|FETAL PROGRAMMING |METABOLIC DISORDER |LIPOGENIC ENZYMES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38195,"idioma_id":4,"titulo":"Bonding in PdH2 and Pd2H2 systems adsorbed on carbon nanotubes: Implications for hydrogen storage","resumen":"This work presents a bonding study of hydrogen adsorption processes on palladium decorated carbon nanotubes by using the density functional theory (DFT). First, we considered simple decoration models involving single palladium atoms or palladium dimers, and then we analyzed the adsorption of several molecular and dissociated hydrogen coordination structures, including Kubas-type complexes. In all cases we computed the energy, bonding and electronic structure for the different nanotube-supported hydrogen-palladium systems. Our results show that Pd(H2) and Pd2(H2) complexes with relaxed but not dissociated H-H bonds are the most stable adsorbed systems. The role of s, p and d orbitals on the bonding mechanism for all adsorbates and substrates was also addressed. We found intermolecular donor-acceptor C-Pd and Pd-H delocalizations after adsorption. We also studied the palladium clustering effect on the hydrogen uptake based on Kubas-type bonding. © 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.","palabras_clave":"HYDROGEN STORAGE|CARBON NANOTUBES|PALLADIUM|CLUSTERING|DFT|BONDING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38196,"idioma_id":4,"titulo":"Probing the radio emission from air showers with polarization measurements","resumen":"The emission of radio waves from air showers has been attributed to the so-called geomagnetic emission process. At frequencies around 50 MHz this process leads to coherent radiation which can be observed with rather simple setups. The direction of the electric field induced by this emission process depends only on the local magnetic field vector and on the incoming direction of the air shower. We report on measurements of the electric field vector where, in addition to this geomagnetic component, another component has been observed that cannot be described by the geomagnetic emission process. The data provide strong evidence that the other electric field component is polarized radially with respect to the shower axis, in agreement with predictions made by Askaryan who described radio emission from particle showers due to a negative charge excess in the front of the shower. Our results are compared to calculations which include the radiation mechanism induced by this charge-excess process.","palabras_clave":"Cosmic rays|Pierre Auger|Radio emission"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38197,"idioma_id":4,"titulo":"Adjuvant activity of CpG-ODN formulated as a liquid crystal","resumen":"The adjuvants approved in human vaccine with recombinant\/puri&#64257;ed antigens induce weak cellular immune response and so the development of new adjuvant strategies is critical. CpG-ODN has successfully been used as an adjuvant (phase IeIII clinical trials) but its bioavailability needs to be improved.  We investigated the adjuvant ability of CpG-ODN formulated with a liquid crystal nanostructure of 6-O ascorbyl  palmitate  (Coa-ASC16).  Mice  immunized  with  OVA\/CpG-ODN\/Coa-ASC16  elicited  a  potent speci&#64257;c IgG1, IgG2a, Th1 and Th17 cellular response without systemic adverse effects. These responses  were superior to those induced by OVA\/CpG-ODN (solution of OVA with CpG-ODN) and to those induced by the formulation OVA\/CpG-ODN\/Al(OH)3. Immunization with OVA\/CpG-ODN\/Coa-ASC16 resulted in a long-lasting cell-mediated immune response (at least 6.5 months). Furthermore, Coa-ASC16 alone allows a controlled release of CpG-ODN in vitro and induces local in&#64258;ammatory response, independent of TLR4 signaling, characterized by an in&#64258;ux of neutrophils and Ly6C high monocytes and pro-in&#64258;ammatory cytokines. Remarkably, the adjuvant capacity of CpG-ODN co injected with Coa-ASC16 (OVA\/CpG-ODN plus Coa-ASC16) was similar to the adjuvant activity of OVA\/CpG-ODN, supporting the requirement for whole  formulation  to  help  CpG-ODN  adjuvanticity.  These  results  show  the  potential  of  this  formulation, opening a new avenue for the development of better vaccines.","palabras_clave":"CpG-ODN  |Adjuvant Vaccine|Ascorbyl palmitate| Liquid crystal"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38198,"idioma_id":4,"titulo":"Plasticity in sunflower leaf and cell growth under high salinity","resumen":"A group of sunflower lines that exhibit a range of leaf Na+ concentration under high salinity was used to explore whether the responses to the osmotic and ionic components of salinity can be distinguished in leaf expansion kinetics analysis. It was expected that at the initial stages of the salt treatment, leaf expansion kinetics changes would be dominated by responses to the osmotic component of salinity, and that, later on, ion inclusion would impose further kinetics changes. It was also expected that differential leaf Na+ accumulation would be reflected in specific changes in cell division and expansion rates.   \tPlants of four sunflower lines were gradually treated with a relatively high (130 mM NaCl) salt treatment. Leaf expansion kinetics curves were compared in leaves that were formed before, during and after the initiation of the salt treatment. Leaf areas were smaller in salt treated plants, but the analysis of growth curves did not reveal differences that could be attributed to differential Na+ accumulation, since similar changes in leaf expansion kinetics were observed in lines with different magnitudes of salt accumulation. Nevertheless, in a high leaf Na+-including line, cell divisions were affected earlier, resulting in leaves with proportionally fewer cells than in a Na+-excluding line.   A distinct change in leaf epidermal pavement shape caused by salinity is reported for the first time. Mature pavement cells in leaves of control plants exhibited typical lobed, jigsaw-puzzle shape, whereas in treated plants, they tended to retain closer-to-circular shapes and a lower number of lobes.","palabras_clave":"SUNFLOWER|LEAF GROWTH|CELL SHAPE|MORPHOMETRIC ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38199,"idioma_id":4,"titulo":"Effectiveness of foot and mouth disease systematic mass vaccination campaigns in Argentina","resumen":"The objective of this paper is to evaluate the effectiveness of  systematic mass vaccination campaigns against foot and mouth  disease in Argentina. The analysis was based on an estimation of the  proportion of protected animals and protected farms in vaccinated  populations, as reflected by levels of antibodies measured in liquidphase  enzyme-linked immunosorbent assay. The analysis was carried  out in 42 animal health districts in Buenos Aires province, using data  collected from four cross-sectional studies, in 2004, 2007, 2008 and  2011. Cattle were assigned to one of two categories on the basis of  correlation between serological titres and expected percentage  protection: non-adequately protected (expected protection <75%) and  adequately protected (expected protection &#61619;75%). The proportions of  adequately protected cattle and significantly non-adequately protected  farms were estimated and compared among sampled locations.  Protection was variable among the districts; cattle aged one to two  years showed higher levels of protection than cattle six to 12 months  old, and the proportion of protected cattle was higher in the more  recent studies. The results of the analysis will allow the national  animal health service to investigate in depth those districts where  protection was lower than the regional background protection. The  authors propose that this methodology could be used to evaluate the  effectiveness of vaccination campaigns in other countries or zones  where systematic foot and mouth disease mass vaccination campaigns  are undertaken.","palabras_clave":"VIRUS DE LA FIEBRE AFTOSA|EPIDEMIOLOGIA |VACUNACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38200,"idioma_id":4,"titulo":"Typical cyperoid reproductive structures in Lipocarpha humboldtiana and Ascolepis brasiliensis (Cypereae-Cyperoideae-Cyperaceae): new evidence from a development perspective","resumen":"Ascolepis and Lipocarpha, Cyperaceae, have highly reduced reproductive structures and hypogynous scales that are controversially appreciated. Because of this, flowers and spikelets and, thus, inflorescences have been interpreted in different ways, which, in turn, has led to placing the two genera in different tribes. Some authors interpret spikelets in Ascolepis and Lipocarpha as many-flowered and the so-called hypogynous scales as homologous to the lateral scales of Hypolytrum, or consider these scales comparable to a Scirpus bristle. However, many other authors consider spikelets in Lipocarpha and Ascolepis to be a result of a reductional process from a many-flowered cyperoid spikelet to a single-flowered spikelet, where the adaxial and abaxial hypogynous scales may be seen as the respective prophyll and glume of the reduced spikelets. The latest molecular phylogenies of Cyperaceae show both genera nested in the Cyperus clade, forming, in turn, a clade together with the rest of the Cypereae genera having single-flowered spikelets and hypogynous scales. Alternatively, based on this, the scales of uncertain homology that accompany the Ascolepis and Lipocarpha flower might be seen as special reproductive formations, representing a synapomorphy of such clade, instead of relicts of an ancestor with many-flowered spikelets. In view of this, freshly collected inflorescences of Lipocarpha humboldtiana Nees and Ascolepis brasiliensis (Kunth) Benth. ex C. B. Clarke were studied using light and scanning electron microscopy, with the aim of elucidating the nature of the controversially interpreted reproductive structures of these species from a development perspective. Results show that the ?hypogynous scales? simply represent vestigial structures derived from the reduction of typical cyperoid spikelets, rather than a perianth part or specialized formations emerging as evolutionary novelties. Two scales are typically generated in both species, one being abaxial and the other adaxial, homologous to a glume and a prophyll, respectively, which contrasts with the eprophyllate condition so far attributed to Ascolepis. In both cases, the inflorescence is a spike of reduced spikelets, and the floral development in L. humboldtiana and in A. brasiliensis follows the general ontogenetic pattern observed in Cyperoideae. These characteristics support the inclusion of both genera in the Cypereae tribe.","palabras_clave":"FLOWER|SPIKELET|INFLORESCENCE|DEVELOPMENT|LIPOCARPHA|ASCOLEPIS|CYPEREAE|CYPEROIDEAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38201,"idioma_id":4,"titulo":"In vitro anticancer activity and SAR studies of triazolyl aminoacyl(peptidyl) penicillins","resumen":"A library of triazolyl aminoacyl(peptidyl) penicillins was designed, synthesized, and evaluated for their antiproliferative activity against HeLa and B16-F0 cell lines. Structure-activity relationship studies were carried out, and minimal structural requirements were determined. Among the tested compounds, derivatives 7f, 7p and 7m demonstrated the highest anticancer activity and a promising selectivity profile against these two cell lines.","palabras_clave":"TRIAZOLYL AMINOACYL PENICILLINS|MOLECULAR HYBRIDIZATION|ANTICANCER ACTIVITY|STRUCTURE ACTIVITY RELATIONSHIP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38202,"idioma_id":4,"titulo":"Counterrotating stars in simulated galaxy discs","resumen":"Counterrotating stars in disc galaxies are a puzzling dynamical feature whose origin has been ascribed to either satellite accretion events or to disc instabilities triggered by deviations from axisymmetry. We use a cosmological simulation of the formation of a disc galaxy to show that counterrotating stellar disc components may arise naturally in hierarchically clustering scenarios even in the absence of merging. The simulated disc galaxy consists of two coplanar, overlapping stellar components with opposite spins: an inner counterrotating bar-like structure made up mostly of old stars surrounded by an extended, rotationally supported disc of younger stars. The opposite-spin components originate from material accreted from two distinct filamentary structures which at turn around, when their net spin is acquired, intersect delineating a ?V?-like structure. Each filament torques the other in opposite directions; the filament that first drains into the galaxy forms the inner counterrotating bar, while material accreted from the other filament forms the outer disc. Mergers do not play a substantial role and most stars in the galaxy are formed in situ; only 9 per cent of all stars are contributed by accretion events. The formation scenario we describe here implies a significant age difference between the co- and counterrotating components, which may be used to discriminate between competing scenarios for the origin of counterrotating stars in disc galaxies.","palabras_clave":"Galaxy: disc|Galaxy: formation|Galaxy: kinematics and dynamics|Galaxy: structure"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38203,"idioma_id":4,"titulo":"Asterococcus superbus as a biosorbent of copper, zinc, cadmium and lead. Adsorption isotherm and kinetic modeling","resumen":" The adsorption capacity of copper, zinc, cadmium and lead by   Asterococcus superbus, a freshwater microalgae, was studied in batch   mode. The Langmuir, Freundlich, Temkin and Dubinin-Radushkevich models   were applied and results demonstrate that for all cases the Langmuir   model best describes the adsorption process and that A. superbus   isotherm followed the bisorption series, Zn &gt; Cu &gt; Pb &gt; Cd.   Kinetic studies demonstrate that the adsorption of zinc and copper   follows a pseudo-second-order kinetic model, and that of cadmium and   lead follows a pseudo first-order kinetic model. Natural waters present   an increasing concentration of heavy metals, mainly due to the effluent   discharge in these type or reservoirs. The importance of the present   work is to contribute to the study of new methods to diminish the   presence of heavy metals in natural waters.        ","palabras_clave":"Asterococcus superbus| freshwater algae|biosorbents|adsorption isotherms"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38204,"idioma_id":4,"titulo":"Non-linear excitation of polariton cavity modes in ZnO single nanocombs","resumen":"Tunable second harmonic (SH) polaritons have been efficiently generated in ZnO nanocombs, when the material is excited close to half of the band-gap. The nonlinear signal couples to the nanocavity modes, and, as a result, Fabry-Pérot resonances with high Q factors of about 500 are detected. Due to the low effective volume of the confined modes, matter-light interaction is very much enhanced. This effect lowers the velocity of the SH polariton in the material by 50 times, and increases the SH confinement inside the nanocavity due to this higher refractive index. We also show that the SH phase-matching condition is achieved through LO-phonon mediation. Finally, birrefringence of the crystal produces a strong SH intensity dependence on the input polarization, with a high polarization contrast, which could be used as a mechanism for light switching in the nanoscale.","palabras_clave":"SEMICONDUCTOR NONLINEAR OPTICS INCLUDING MQW|NANOMATERIALS|MICROCAVITIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38205,"idioma_id":4,"titulo":"Spatial Patterns in Late Holocene Lithic Projectile Point Technology of Tierra del Fuego (Southern South America): Assessing Size and Shape Changes","resumen":"This paper focuses on the application of geometric morphometrics to the study of the lithic record in southern South America. We review the Regional background, discuss methodological issues and summarize research advances. Here a geometric morphometric approach is applied to the case study of Late Holocene stemmed lithic projectile points from Grande Island of Tierra del Fuego (southernmost South America). Our aim is to assess size and shape changes in a broad spatial scale. Projectile point morphometric  variations are used to discuss spatial scales of interaction and Differentiation among past human populations across the island. Finally, several hypotheses are introduced to explain the patterns observed.","palabras_clave":"GEOMETRIC MORPHOMETRIC|LITHIC PROJECTILE POINTS|TIERRA DEL FUEGO|HUNTER-GATHERERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38206,"idioma_id":4,"titulo":"Palladium-Catalyzed Cross-Coupling Reactions of Arylsiloxanes with Aryl Halides: Application to Solid-Supported Organic Synthesis","resumen":"The solid-phase version of the Pd-catalyzed Hiyama reaction between a variety of aryltriethoxysilanes and immobilized aryl halides was developed. Smooth crosscoupling was achieved to afford the corresponding biaryl products in moderate to excellent yields. The described protocol would be particularly useful for the construction of 4&#8242;-substituted 1,1&#8242;-biphenyl derivatives.","palabras_clave":"HIYAMA|SOLID PHASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38207,"idioma_id":4,"titulo":"Pharmaceutical impurities and degradation products: Uses and applications of NMR techniques","resumen":"Current  standards and regulations demand the pharmaceutical industry not only to  produce highly pure drug substances, but to achieve a thorough understanding of  the impurities accompanying their manufactured drug substances and products. These  challenges have become important goals of process chemistry and have steadily stimulated  the search of impurities after accelerated or forced degradation procedures.             As a  result, impurity profiling is one of the most attractive, active and relevant  fields of modern pharmaceutical analysis. This activity includes the  identification, structural elucidation and quantitative determination of  impurities and degradation products in bulk drugs and their pharmaceutical  formulations.            Nuclear  magnetic resonance (NMR) spectroscopy has evolved into an irreplaceable approach  for pharmaceutical quality assessment, currently playing  a critical role in  unequivocal structure identification as well as structural confirmation  (qualitative detection), enabling the understanding of the underlying mechanisms  of the formation of process and\/or degradation impurities.             NMR  is able to provide qualitative information without the need of standards of the  unknown compounds and multiple components can be quantified in a complex sample  without previous separation. When coupled to separative techniques, the  resulting hyphenated methodologies enhance the analytical power of this  spectroscopy to previously unknown levels. As a result, and by enabling the implementation  of rational decisions regarding the identity and level of impurities, NMR  contributes to the goal of making better and safer medicines.           Herein are discussed  the applications of NMR spectroscopy and its hyphenated derivate techniques to  the study of a wide range pharmaceutical impurities. Details on the advantages  and disadvantages of the methodology and well as specific challenges with  regards to the different analytical problems are also presented. ","palabras_clave":"NMR spectroscopy|Pharmaceutical impurities|Structural elucidation|Qualitative and quantitative analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38208,"idioma_id":4,"titulo":"A non-coding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects","resumen":"Richieri-Costa-Pereira syndrome is an autosomal-recessive acrofacial dysostosis characterized by mandibular median cleft associated with other craniofacial anomalies and severe limb defects. Learning and language disabilities are also prevalent.We mapped the mutated gene to a 122 kb region at 17q25.3 through identity-by-descent analysis in 17 genealogies. Sequencing strategies identified an expansion of a region with several repeats of 18- or 20-nucleotide motifs in the 50 untranslated region (50 UTR) of EIF4A3, which contained from 14 to 16 repeats in the affected individuals and from 3 to 12 repeats in 520 healthy individuals. A missense substitution of a highly conserved residue likely to affect the interaction of eIF4AIII with the UPF3B subunit of the exon junction complex in trans with an expanded allele was found in an unrelated individual with an atypical presentation, thus expanding mutational mechanisms and phenotypic diversity of RCPS. EIF4A3 transcript abundance was reduced in both white blood cells and mesenchymal cells of RCPSaffected individuals as compared to controls. Notably, targeting the orthologous eif4a3 in zebrafish led to underdevelopment of several craniofacial cartilage and bone structures, in agreement with the craniofacial alterations seen in RCPS. Our data thus suggest that RCPS iscaused by mutations in EIF4A3 and show that EIF4A3, a gene involved in RNA metabolism, plays a role in mandible, laryngeal, and limb morphogenesis.","palabras_clave":"Noncoding Expansion|Richieri-Costa-Pereira Syndrome|Craniofacial Disorder|Limb Defects"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38209,"idioma_id":4,"titulo":"Study on target-film structural correlation in thin cobalt ferrite films grown by Pulsed Laser Deposition technique","resumen":"We prepared three films of crystalline cobalt ferrite with identical deposition conditions  (time, temperature, pressure) using three different targets consolidated from CoFe2O4 (CFO)  crystalline nanoparticles (NPs) by a standard pressing. The NPs were previously prepared by chemical route varying their synthesis conditions in order to promote variations in the degree of structural distortions. The purpose of this work is to study how the degree of crystal distortion of precursor material (target) influences the structural properties of the films when they are grown by pulsed laser deposition (PLD) technique. 57Fe Mössbauer spectroscopy was used to study the local environment of iron atoms in the powders (targets for PLD). The Williamson-Hall plots were used to show the degree of the strain present in the films. XANES spectra of the films taken in grazing incidence geometry were also carried out. The results explicitly demonstrate that the film with the poorest degree of quality was deposited using structurally more imperfect CoFe2O4 powders whereas the most perfect film was that grown using the best powder from the structural point of view. These results were reinforced indirectly by means of magnetic measurements (exchange bias effect) in Fe\/CFO bilayers (thin iron film was deposited additionally for this purpose) when hysteresis loops were analyzed after field cooling at 3 T magnetic field. We showed that the quality of thin cobalt ferrite films does structurally depend on the quality of precursor material when PLD technique is involved.","palabras_clave":"películas delgadas|propiedades magneticas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38210,"idioma_id":4,"titulo":"Detection of bovine herpesvirus 2 and bovine herpesvirus 4 DNA in trigeminal ganglia of naturally infected cattle by polymerase chain reaction","resumen":"Establishment of latent infection within specific tissues in the host is a common biological feature of the herpesviruses. In the case of bovine herpesvirus 2 (BoHV-2), latency is established in neuronal tissues, while  bovine herpesvirus 4 (BoHV-4) and ovine herpesvirus 2 (OvHV-2) latent virus targets on cells of the monocytic lineage. This study was conducted in quest of BoHV-2, BoHV-4 and OvHV-2 DNA in two hundred trigeminal ganglia (TG) specimens, derived from one hundred clinically healthy cattle, majority of them naturally infected with bovine herpesvirus 1 (BoHV-1) and bovine herpesvirus 5 (BoHV-5). Total DNA extracted from ganglia was analyzed by polymerase chain reactions (PCR) designed to amplify part of the genes coding for BoHV-2, and BoHV-4 glycoprotein B and, for OvHV-2, the gene coding for phosphoribosylformylglycinamidine synthase-like protein. BoHV-2 DNA was detected in TG samples of two  (2%) and BoHV-4 DNA in nine (9%) of the animals, whereas OvHV-2 DNA could not be detected in any of the TG DNA. The two animals in which BoHV-2 DNA was identified were also co-infected with BoHV-1 and BoHV-5. Within the nine animals in which BoHV-4 DNA was detected, six were also co-infected with BoHV-1 and BoHV-5. This report provides for the first time evidence that viral DNA from BoHV-2 and BoHV-4 can be occasionally detected in TG of naturally infected cattle. Likewise, in this report we provided  for the first time evidence that the co-infection of cattle with three distinct bovine herpesviruses might be a naturally occurring phenomenon.","palabras_clave":"bovine herpesvirus|ovine herpesviru|PCR|Latency"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38211,"idioma_id":5,"titulo":"Sobre el testimonio: Una introducción","resumen":"Introducción de Claudia Bacci y Alejandra Oberti al Dossier temático coordinado por ellas: 'Testimonio: debates y desafíos desde América Latina'.","palabras_clave":"Testimonio|Historia|Metodología|Género"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38212,"idioma_id":5,"titulo":"Entre lo público y lo privado: los testimonios sobre la violencia contra las mujeres en el terrorismo de Estado en Argentina","resumen":"Los procesos judiciales más recientes por crímenes cometidos  durante el terrorismo de Estado en Argentina han permitido  visibilizar las distintas formas en las que se ejerció la  violencia contra las mujeres detenidas y secuestradas que,  hasta hace pocos años, permanecía mayormente ocluida al  conocimiento público. Las reflexiones que presentamos en  estas páginas retoman un trabajo más amplio en el cual se  analizaron más de sesenta testimonios de mujeres que forman  parte del Archivo Oral de Memoria Abierta. Son entrevistas  que refieren, entre otras cuestiones, a las distintas  modalidades de violencia dirigida especialmente contra las  mujeres en centros clandestinos de detención y cárceles  como parte del sistema represivo del terrorismo de Estado.  Se trata de relatos que, de modos diversos, denuncian y reflexionan  sobre esa violencia, sus manifestaciones, impactos  subjetivos y ecos en el presente. En este trabajo el foco estará  puesto en lo que las entrevistadas dicen a propósito de los  lugares, momentos e interlocutores con quienes han podido  o querido hablar de esas vivencias y sus secuelas, y a sus  percepciones sobre la experiencia de tomar la palabra, ya sea  para denunciar judicialmente o para narrar sus experiencias.","palabras_clave":"Testimonio|Violencia |Género|Dictadura"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38213,"idioma_id":5,"titulo":"Los evangélicos en la arena política del Conurbano. Dilemas y horizontes de una apuesta religiosa territorial","resumen":"En este artículo analizamos la participación partidaria de actores evangélicos en el Conurbano Bonaerense (Argentina), en el segundo milenio. Una modalidad territorial, cuyo principales componentes son a) el liderazgo social de los pastores, b) la afinidad con el peronismo, b) la interpelación a la comunidad evangélica y a los sectores populares empobrecidos como base de sustentación y d) la reproducción del imaginario en torno al  voto evangélico. Además de caracterizar estos elementos, evaluaremos los alcances de estas experiencias en la arena electoral y sus implicancias para el debate en torno a la politicidad del fenómeno evangélico en Argentina.","palabras_clave":"EVANGÉLICOS|POLÍTICA|CONURBANO|PERONISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38214,"idioma_id":4,"titulo":"Photodynamic inactivation of oropharyngeal Candida strains","resumen":"Oropharyngeal candidiasis (OPC) is an infection frequent in immunocompromised patients. Photody-namic therapy is an alternative to conventional treatments, based on the utilization of compounds thatinhibit or kill microorganisms only under the effect of light, process known as Photodynamic Inactivation(PDI). In the present study, PDI of Candida spp. by the natural product &#945;-terthienyl (&#945;-T) was investigatedfollowing the guidelines of CLSI M27-A3, under UV-A light irradiation.The optimal values of two variables, exposure irradiation time (ET) and distance to the irradiationsource (DIS) were established by employing Design Expert Software (DES). For this purpose, a panel ofCandida strains isolated from OPC (C. albicans, C. tropicalis, C. parapsilosis and C. krusei) was employedand optimal values were 5 min (ET) and between 6.06 and 6.43 cm (DIS) with a desirability factor of0.989. -T plus UV-A light in the optimal conditions caused a complete reduction in viable cells in 5 minwhich was demonstrated by viable cells reduction assays and confocal microscopy after vital staining(propidium iodide\/fluorescein diacetate). The germ tube formation of C. albicans was inhibited by -T atsub-inhibitory concentrations. Results showed that -T plus UV-A light could constitute an alternativefor OPC treatments at the optimal conditions determined here.","palabras_clave":"Photodynamic therapy|alpha-Terthienyl|Antifungal activity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38215,"idioma_id":4,"titulo":"MRSA Pediatric clone expressing ermC plus lnuA genes causing  nosocomial transmission and healthcare workers colonization  in a neonatal intensive care unit.","resumen":"      Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of both nosocomial  and community-acquired infections. We describe an outbreak caused by the MRSA  Pediatric clone  expressing an unusual lincosamide resistant phenotype. Between  January and May 2006, an MRSA outbreak was detected at the Neonatal Unit of  Hospital Interzonal General de Agudos ?Evita?, Buenos Aires Province, Argentina  that affected ten patients. Seven isolates from seven patients plus five MRSA  recovered from health care workers (nasal carriage) were studied. Two  phenotypes were observed: i) ELCi (10), resistance to erythromycin and  lincomycin and inducible resistance over clindamycin; ii) ELiCi (2), resistance  to erythromycin and inducible resistance over lincomycin and clindamycin. All  12 MRSA were resistant to oxacillin, erythromycin and gentamicin. Isolates  expressing the ELCi-phenotype showed lincomycin MIC values between 16-32 mg\/L,  while the remaining 2 isolates with ELiCi-phenotype presented a MIC value of  0.5 mg\/L. No differences were observed between the clindamycin MIC values in  both phenotypes, ranging 0.25-0.5 mg\/L. Isolates showing ELCi-phenotype  harbored ermC plus lnuA genes, and the other two only ermC gene. All 12 isolates were  genetically related and belonged to the Pediatric clone (ST100) harboring a new  variant of SCCmecIV. This is the  first MRSA outbreak expressing an unusual ELCi phenotype due to a combination  of ermC plus lnuA genes.  ","palabras_clave":"MRSA|OUTBREAK|LNUA|NEONATAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38216,"idioma_id":4,"titulo":"Soybean nitrogen uptake and utilization in Argentina and United States cultivars","resumen":"Crop production increase needed to satisfy a growing world population depends, at least partially, on increasing current genetic gain.  Theory proposes increased genetic gains can be attained using diverse high-yielding parents. Physiological traits, compared to molecular or morphological markers, are hypothesized to better estimate functional diversity. Any trait-based hybridization approach will require assessing genotypic diversity for physiological traits. Here, we phenotyped several traits using two physiological frameworks to assess diversity in 25 and 65 elite cultivars from Argentina (ARG) and USA, respectively. First, we identified the highest yielding cultivars clusters across two environments in ARG and USA. These cultivars had also the highest N uptake at both ARG and USA. Therefore, there was no genotypic diversity for total N uptake within each cluster. For some other traits, the highest yielding clusters had the highest values but for others it was not the case. In any case, there was residual diversity within ARG and USA highest yielding clusters in temporal pattern of N uptake, N use efficiency to attain high yield (biomass per unit of N absorbed at R7) and N harvest index. Stacking all traits in one cultivar could potentially increase yield 13%. The possibility of such stacking, however, depends on the nature of the phenotypic correlation among traits. We demonstrated several trade-off correlations between phenotyped traits, thought to hinder stacking, are actually not biologically based.","palabras_clave":"Soybean|Nitrogen|Yield"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38217,"idioma_id":4,"titulo":"Syphilis, HIV and other Infections: a continuing challenge","resumen":"Syphilis, HIV and other infections should be considered in patients with dermatology clinic lesions. We report   the case of a young female who showed multiple lesions arond genital and perigenital areas. The dark field microscopy   and serological study for syphilis and HIV were positive. Four months later she showed ulcerations which evidenced a   partial response to penicillin treatment. The histopathology of skin biopsy reported ?compatible with donovanosis? so she   was treated with trimethoprim-sulfamethoxazole. Several months later, biopsy and scrapings of new lesions were   performed and  Histoplasma capsulatum was detected. Itraconazole therapy was initiated and after three years she   returned with almost complete remission of the lesions.","palabras_clave":"Syphilis, HIV|sexually transmitted disease|histoplasmosis|donovanosis."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38218,"idioma_id":4,"titulo":"Infl uence of pre-Andean history over Cenozoic foreland deformation: Structural styles in the Malargüe fold-and-thrust belt at 35°S, Andes of Argentina","resumen":"The Andes are the classic example of a  subduction-related orogen. Segmentation of the orogenic belt is related to dynamics of the subduction zone and to upper plate thermomechanical  properties. Understanding the controlling factors on deformation along the orogen requires studying cross sections at different latitudes and determining the respective roles of plate interactions, upper plate  weakness zones, and crustal architecture. A newly constructed balanced cross section of the Argentinean Andes at 35°S, in the transition  between a fl at-slab and a normal subduction segment, shows tectonic inversion of Mesozoic normal faults and development of new thrusts during Andean shortening. Estimated shortening of 26.2 km, equivalent to  22% of the initial length, is lower than previous estimates obtained from partial cross sections using non-inversion structural models.  Comparison of this estimate with crustal area balance constrained by geophysical data indicates that (1) crustal thickness was varied  across the transect before Andean shortening, with a thick (~45 km) crustal block to the west related to late Paleozoic orogeny, and  a thinner block (~32 km) in the east related to Mesozoic stretching; and (2) a structural model incorporating tectonic inversion is consistent with regional shortening and crustal thickness trends. Our results underscore the role of the inherited characteristics of the upper plate in subduction-related orogens, including preexisting faults and preorogenic crustal thickness variations.","palabras_clave":"pre-Andean history|Cenozoic foreland deformation|Malargüe fold-and-thrust belt|Andes of Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38219,"idioma_id":4,"titulo":"Integrated seismic and gravimetric model of Jocolí Basin, Argentina","resumen":"Estudio de la estructura de la cuenca de antepais de la Precordillera de San Juan a traves de metodos geofisicos","palabras_clave":"SISMICA|GRAVEDAD|ESTRUCTURA|CUENCAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38220,"idioma_id":4,"titulo":"Buffer regulation of calcium puff sequences","resumen":"Puffs are localized Ca2+ signals that arise in oocytes in response to inositol 1,4,5-trisphosphate (IP3). They are the result of the liberation of Ca2+ from the endoplasmic reticulum through the coordinated opening of IP3 receptor\/channels clustered at a functional release site. The presence of buffers that trap Ca2+ provides a mechanism that enriches the spatio?temporal dynamics of cytosolic calcium. The expression of different types of buffers along the cell?s life provides a tool with which Ca2+ signals and their responses can be modulated. In this paper we extend the stochastic model of a cluster of IP3R-Ca2+ channels introduced previously to elucidate the effect of buffers on sequences of puffs at the same release site. We obtain analytically the probability laws of the interpuff time and of the number of channels that participate of the puffs. Furthermore, we show that under typical experimental conditions the effect of buffers can be accounted for in terms of a simple inhibiting function. Hence, by exploring different inhibiting functions we are able to study the effect of a variety of buffers on the puff size and interpuff time distributions. We find the somewhat counter-intuitive result that the addition of a fast Ca2+ buffer can increase the average number of channels that participate of a puff.","palabras_clave":"calcium dynamics|puff sequences|buffers"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38221,"idioma_id":4,"titulo":"AvrA effector protein of  Salmonella enterica  serovar Enteritidis is expressed and translocated in mesenteric lymph nodes at latestages of infection in mice","resumen":"Salmonellosis is a major health problem worldwide. Salmonella   Enteritidis has been a primary cause of Salmonella outbreaks in many   countries. AvrA is an SPI-1 effector protein involved in the enteritis   pathway with critical roles in inhibiting inflammation and apoptosis. In   this work, we constructed an AvrA-FLAG-tagged strain of Salmonella   Enteritidis to analyze the expression profile of AvrA in vitro, in cell   culture and in vivo. AvrA expression and secretion was observed in vitro   under culture conditions that mimic intestinal and intracellular   environments. In agreement, bacteria isolated from infected cell   monolayers expressed and translocated AvrA for at least 24 h post   inoculation. For in vivo experiments, BALB\/c mice were inoculated by the   natural route of infection with AvrA-FLAG strain. Infecting bacteria   and infected cells were recovered from mesenteric lymph nodes. Our   results showed that AvrA continues to be synthesized in vivo up to day 8   post inoculation. Moreover, AvrA translocation was detected in the   cytosol of cells isolated from lymph nodes 8 days after infection.   Interestingly, we observed that AvrA is secreted by both SPI-1 and SPI-2   TTSS. In summary, these findings indicate that AvrA expression is not   constrained to the initial host-bacteria encounter in the intestinal   environment as defined previously. AvrA effector may participate also in   systemic Salmonella Enteritidis infection.","palabras_clave":"Salmonella pathogenicity island|SPI|Effector protein|Avra"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38222,"idioma_id":4,"titulo":"Dam methylation regulates the expression of SPI-5-encoded sopB gene in Salmonella enterica serovar Typhimurium","resumen":"DNA adenine methylation is an essential factor in Salmonella virulence. Here, we investigate the involvement of DNA adenine methylase (Dam) in the expression and translocation of a SPI-5-encoded effector of S. Typhimurium. SopB expression and secretion were determined using SopB?FLAG-tagged wild type and dam strains of S. Typhimurium. Western blot and quantitative reverse transcriptase PCR analysis showed that the dam mutant expresses lower levels of SopB protein and sopB mRNA than the wild type strain under SPI-1 and SPI-2 inducing conditions in vitro. SopB secretion was also considerably impaired in the absence of dam. In agreement with in vitro experiments, SopB synthesis in dam mutants recovered from infected epithelial cells and from murine mesenteric lymph nodes was reduced by 40% respect to the wild type strain (p < 0.05). SopB translocation was neither detected in the cytosol of epithelial cells nor in the cytosol of cells isolated from mesenteric lymph nodes infected with the dam mutant. Taken together, our results demonstrate that, in S. Typhimurium, Dam methylation modulates the expression and translocation of SPI-5 encoded SopB effector.","palabras_clave":"SALMONELLA|DAM|SOP, B"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38223,"idioma_id":4,"titulo":"Nucleophilic non-metal assisted trifluoromethylation and perfluoroalkylation reactions of organic substrates","resumen":"outstanding progress has been observed during the last few decades to effect fluoroalkyl group addition or substitution reactions","palabras_clave":"NUCLEOPHILIC TRIFLUOROMETHYLATION|trimehylsilyltrifluoromeyhane"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38224,"idioma_id":5,"titulo":"Guías Latinoamericanas de la RIICER para el diagnóstico de las rickettsiosis transmitidas por garrapatas","resumen":"Tick-borne rickettsioses are worldwide infectious diseases that are considered emerging and re-emerging. Until recently the only tick-borne rickettsiosis present in Latin America was Rickettsia rickettsii infection, but to date, with the incorporation of new tools as PCR and sequencing and the quick cellular close tube cultures (Shell-vial), new species has been involved as human pathogens. In these guidelines, we offer an update of the microbiological assays for diagnosing rickettsioses. Besides we have included a section in which the most important hard ticks involved in human rickettsioses in Latinoamerica are detailed. ","palabras_clave":"RICKETTSIAS|GARRAPATAS|LATINOAMERICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38226,"idioma_id":4,"titulo":"Study of the life cycle of Amblyomma dubitatum (Acari: Ixodidae) based on field and laboratory data","resumen":"The life cycle of Amblyomma dubitatum was described based on the seasonaldistribution of all parasitic stages and the development periods of engorged ticks underdifferent conditions of photoperiod and temperature. All stages were found active along theentire year in the study area. Larvae peaked from May to July, nymphs peaked from July toOctober, and females peaked from November to March. This pattern represents a life cyclewith one generation per year with most of the ticks reaching adulthood during the warmestmonths. The analysis of the effect of the photoperiod on the development of A. dubitatumshowed no indication of morphogenetic diapause. Exposure of ticks to field conditionsindicates a delay in metamorphosis of immature stages, in the oviposition of females and inthe incubation of eggs, which were associated with low winter temperatures. The resultsindicate that though A. dubitatum has a one year life cycle, more than one cohort can coexistwithin the same population in a certain interval of time. Finally, the potential role ofsmall rodents as hosts for larvae and nymphs of A. dubitatum is confirmed.","palabras_clave":"AMBLYOMA DUBITATUM|LIFE CYCLE|HOST|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38227,"idioma_id":4,"titulo":"Signal transduction mechanism of biased ligands at histamine H2 receptors","resumen":"7TMR exists as conformational collections in which different conformations would lead to differential downstream behaviors such as receptor phosphorylation, G-protein activation and receptor internalization among others. In this context, a ligand may cause differential activation of some, but not all, of the signaling events, which are associated to a particular receptor, and it would lead to biased agonism. The aim of the present work is to study if histamine H2 receptor (H2R) ligands -described as inverse agonists because of their negative efficacy at modulating adenylyl cyclase- could display some positive efficacy concerning receptor desensitization, internalization or even signaling through an adenylyl cyclase independent pathway. Our present findings indicate that treatment with H2R inverse agonists leads to receptor internalization in HEK293T transfected cells, by a mechanism mediated by arrestin and dynamin but being independent of GRK2-mediated phosphorylation. On the other hand we prove that two of the H2R inverse agonists tested, ranitidine and tiotidine, also induce receptor desensitization. Finally, we show that these ligands are able to display positive efficacy towards ERK1\/2 pathway by a mechanism that involves G&#946;&#947; and PI3K mediated signaling in both HEK293T transfected cells and human gastric adenocarcinoma cells. These results point to the aspect of pluridimensional efficacy of H2R as a phenomenon that could be extended to naïve cells, and challenge previous classification of pharmacologically relevant histaminergic ligands.","palabras_clave":"INVERSE AGONIST|cAMP|HISTAMINE RECEPTOR|INTERNALIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38228,"idioma_id":5,"titulo":"In vitro activity against Leishmania and human skin  permeation of miltefosine ultradeformable liposomes","resumen":"ABSTRACT           Introduction:      miltefosine ultradeformable liposomes (MIL-LUD) are an option for   the topical    treatment of cutaneous leishmaniasis penetrating the skin   layers to the dermis    where the parasite inhabits.       Objective:   to design MIL-LUD and determine their in vitro activity against    L.   (Viannia) panamensis and L. (V.) braziliensis and to determine human   skin    permeation.       Methods: MIL-LUD,   phosphatidylcholine liposomes (MIL-LConv) and fluorescent    MIL-LUD   (MIL-LUD-Fluo) were prepared by lipid film rehydration method. They      were physicochemically characterized to determine drug release in   semisynthetic    membrane, retention in skin layers and permeation on   human skin membranes. Cytotoxicity    in THP-1 was determined by the MTT   colorimetric test and activity in promastigotes    and intracellular   amastigotes by microscopic counting.       Results: the size,   the polydispersion index, the Zeta potential and phospholipid      content were 100.7 nm, 0.147, -12.0mV and 53.24mM, respectively for   MIL-LUD.    MIL flow through the semisynthetic membrane was greater with   MIL-LUD than MIL-free    treatment. MIL-LUD treatment induced lower MIL   accumulation in the stratum corneum    and increased permeation than   MIL free treatment. The MIL-LUD and MIL-Conv maintained    MIL activity   in parasites and cells. The MIL-LUD was more toxic to cells than      MIL-Conv and more active against intracellular amastigotes of L. (V.)   braziliensis.       Conclusion: prepared LUD -MIL retained   the anti-leishmanial activity    of the MIL and allowed the compound   release in human skin and membranes. Testing    of experimental   cutaneous leishmaniasis models to evaluate the activity of these      formulations are urgently needed","palabras_clave":"CUTANEOUS LEISHMANIASIS|ULTRADEFORMABLE LIPOSOMES |TOPICAL TREATMENT|MILTEFOSINE|FRANZ DIFFUSION CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38231,"idioma_id":4,"titulo":"Shallow geophysical evaluation of the transition zone between the Guaraní and Yrendá-Toba-Tarijeño aquifer systems (Argentine Gran Chaco)","resumen":"El Gran Chaco Argentino forma parte de la Llanura Chacopampeana, en el antepaís andino, y es principalmente estudiado por información de subsuelo, aunque la geología somera y sistemas hidrogeológicos locales son poco conocidos. Las Lomadas de Otumpa, una topografía sutil N-S, ubicadas en este área (26°- 28° S; 63°- 61° W), representan una zona de transición entre los límites occidental y oriental de los Sistemas Acuíferos regionales Guaraní y Yrendá-Toba-Tarijeño, respectivamente. En este trabajo, se presentan los resultados de dos perfiles O-E (norte: 26º40? S y Sur: 27º S) a través de las Lomadas de Otumpa, obtenidos por sondeos eléctricos verticales y audiomagnetotelúrica. Los inversiones 1-D y 2-D realizadas permitieron definir capas geoeléctricas muy consistentes entre ambos métodos y perfiles. Se identificaron la capa geoeléctrica superior UL (> 20 &#8486; m), las capas geoeléctricas semi-conductivas SC, SC2 y SC3 (6-20 &#8486; m), las capas geoeléctricas conductivas C y C2 (4-8 &#8486; m) y las capas geoeléctricas muy conductivas HC y HC2 (< 5 &#8486; m). Las mayores posibilidades hidrogeológicas de contener agua dulce se presentan en SC y SC2. Estas capas consisten en loess muy limoso y arenisca eólica muy porosa que forman parte de la formación Pampa en el sector norte, de la formación Chaco al sudoeste y de las formaciones Chaco y Tacuarembó al este. La capa más superficial SC tiene 10 metros de espesor, mientras que SC2 tiene 100 metros. Al norte, SC2 otorga continuidad a una capa geoeléctrica análoga identificada al este. Varias perforaciones corroboran la presencia de agua dulce en estos niveles. HC y C en los perfiles audiomagnetotelúricos y C2 en los sondeos eléctricos verticales sugieren la presencia de agua con alto contenido salino (< 8 &#8486; m). Este nivel tiene 100 metros de espesor, es el más explotado del área y se hospeda en las formaciones Pampa y Chaco. La zona saturada de cada nivel es desconocida. El nivel hidrogeológico más profundo HC2 (entre 250 y 350 metros), está hospedado en las formaciones Chaco y Tacuarembó y podría relacionarse al agua termal de alto contenido salino hallada al sudeste a 350 metros de profundidad. Los niveles más someros (SC, SC2, HC, C y C2) se correlacionaron al Sistema Acuífero Toba que hacia el este pasaría al Sistema Acuífero Guaraní, por hospedarse en la Formación Tacuarembó en ese sector. El nivel más profundo HC2 se correlacionó al Sistema Acuífero Guaraní. Los resultados introducen un nuevo modelo geológico-geofísico de las Lomadas de Otumpa que revela niveles hidrogeológicos controlados por la topografía y litología más que por la estratigrafía. Una deformación dúctil incipiente se evidencia en las formas geométricas de HC2 y SC2 y en suaves inclinaciones (SC2, HC y SC) que acompañan la topografía. Finalmente, el presente trabajo presenta relevancia para el conocimiento de los escasos recursos hídricos de esta región. Los resultados permiten definir los acuíferos locales y planificar su utilización. Regionalmente, podrá investigarse la interacción hidrológica entre los Sistemas Acuíferos Guaraní y Yrendá-Toba-Tarijeño de Sudamérica, aunque deben realizarse más estudios.","palabras_clave":"Guaraní aquifer system|Yrendá-Toba-Tarijeño aquifer system| Otumpa hills| audiomagnetotellurics|vertical electrical sounding|Gran Chaco|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38232,"idioma_id":4,"titulo":"Neural Organization of the Second Optic Neuropil, the Medulla, in the Highly Visual Semiterrestrial Crab Neohelice granulata","resumen":".","palabras_clave":"neuroanatomy|behavior|neurons|vision"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38233,"idioma_id":4,"titulo":"Key role of Toll-like receptor 2 in the inflammatory response and major histocompatibility complex class II down-regulation in Brucella abortus-infected alveolar macrophages.","resumen":"ABSTRACTAlveolar macrophages (AM) seem to constitute the main cellular target of inhaledbrucellae. Here we show that Brucella abortus invades and replicates in murine AMwithout inducing cytotoxicity. B. abortus infection induced a statistically significant&nbsp;increase of TNF-&#945;, KC, IL-1&#946;, IL-6 and IL-12 in AM from C57BL\/6 mice and Balb\/c mice,but these responses were generally weaker and\/or delayed as compared to those elicited in&nbsp;peritoneal macrophages. Studies using knockout mice for TLR2, TLR4 and TLR9 revealed&nbsp;that TNF-&#945; and KC responses were mediated by TLR2 recognition. Brucella infection&nbsp;reduced in a MOI-dependent manner the expression of MHC-II molecules induced by&nbsp;gamma-interferon (IFN-&#947;) in AM. The same phenomenon was induced by incubation withheat-killed B. abortus (HKBA) or the lipidated form of the 19 kDa outer membrane proteinof Brucella (L-Omp19), and was shown to be mediated by TLR2 recognition. In contrast,&nbsp;no significant down-regulation of MHC-II was induced by either unlipidated Omp19 or&nbsp;Brucella LPS. In a functional assay, treatment of AM with either L-Omp19 or HKBAreduced the MHC-II-restricted presentation of OVA peptides to specific T cells. One week&nbsp;after intra-tracheal infection viable B. abortus was detected in AM from both wild type and&nbsp;TLR2 KO mice, but CFU counts were higher in the latter. These results suggest that B.&nbsp;abortus may survive in AM after inhalatory infection in spite of a certain degree of immunecontrol exerted by the TLR2-mediated inflammatory response. Both the modest nature of&nbsp;the latter and the modulation of MHC-II expression by the bacterium may contribute to&nbsp;such survival.","palabras_clave":"Brucella|Alveolar macrophages"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38234,"idioma_id":4,"titulo":"Rabies Virus-Like Particles Expressed In HEK 293 Cells","resumen":"Rabies is an infectious viral disease with a mortality rate close to 100%. Currently, there is a need togenerate cheaper and more immunogenic vaccines for the effective prevention of rabies, mostly in devel-oping countries. Virus-like particles have been widely used in viral vaccine production due to their highimmunogenicity and safety during the production process. Rabies virus glycoprotein is the major antigento trigger a protective immune response and the only protein capable of generating virus neutralizingantibodies. In this study we describe the development of a recombinant stable cell line for the productionof rabies virus-like particles (RV-VLPs) expressing the rabies virus glycoprotein by lentivirus-based trans-duction of HEK293 cells. Protein expression was analyzed by flow cytometry, fluorescence microscopy,western blot and ELISA. Particles were purified from culture supernatant and their size and morphologywere studied. Furthermore, mice were immunized with RV-VLPs, formulated with adjuvant, and theseparticles were able to produce a specific antibody response, demonstrating that these virus-like particlespresent a promising rabies vaccine candidate.","palabras_clave":"RABIES|VACCINE|VIRUS-LIKE PARTICLES|HEK293 CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38235,"idioma_id":4,"titulo":"Target cells for antibodies detection in rabies vaccine","resumen":"Rabies causes one of the most lethal zoonotic diseases, with more than 55,000 deaths reported annually. Prevention is based on pre&#8209;exposure vaccination of individuals at high risk of contracting rabies, and mass vaccination of dog, which are the main vector for transmission to humans. Post-exposure prophylaxis includes vaccination and rabies immunoglobulins treatment. The measurement of neutralizing antibodies in sera of vaccinated individuals is a primary concern to determine the efficacy of immunization schedules or the potency of new vaccines. Antibodies against rabies glycoprotein are considered an ideal indicator. In this work we showed the development of a VERO clone that is able to detect by fluorescence microscopy and flow cytometry, the presence of antibodies against the rabies glycoprotein, specifically in its native conformation anchored in the plasma membrane. These cells could trigger the development of a new rapid method for the detection of rabies virus neutralizing antibodies in vaccinated individuals","palabras_clave":"RABIES|NEUTRALIZATION ANTIBODIES|RABIES VIRUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38236,"idioma_id":4,"titulo":"Nanostructured lipid carriers as a strategy to improve the in vitro schistosomiasis activity of praziquantel","resumen":"Praziquantel (PZQ) is a pyrazinoisoquinoline anthelmintic that was discovered in 1972 by Bayer Germany. Currently, due to its efficacy, PZQ is the drug of choice against all species of Schistosoma. Although widely used, PZQ exhibits low and erratic bioavailability because of its poor water solubility. Nanostructured lipid carriers (NLC), second-generation solid lipid nanoparticles, were developed in the 1990s to improve the bioavailability of poorly water soluble drugs. The aim of this study was to investigate nanostructured lipid carriers as a strategy to improve the efficacy of PZQ in S. mansoni treatment. We prepared NLC2 and NLC4 by adding seventy percent glycerol monostearate (GMS) as the solid lipid, 30% oleic acid (OA) as the liquid lipid and two surfactant systems containing either soybean phosphatidylcholine\/poloxamer (PC\/P-407) or phosphatidylcholine\/Tween 60 (PC\/T60), respectively. The carriers were characterized by nuclear magnetic resonance, differential scanning calorimetry, thermogravimetric analysis and Fourier transform-infrared spectroscopy. The safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. The results showed that the encapsulation of PZQ in NLC2 or NLC4 improved the safety profile of the drug. Treatment efficacy was evaluated on the S. mansoni BH strain. PZQ-NLC2 and PZQ-NLC4 demonstrated an improved efficacy in comparison with free PZQ. The results showed that the intestinal transport of free PZQ and PZQ-NLC2 was similar. However, we observed that the concentration of PZQ absorbed was smaller when PZQ was loaded in NLC4. The difference between the amounts of absorbed PZQ could indicate that the presence of T60 in the nanoparticles (NLC4) increased the rigid lipid matrix, prolonging release of the drug. Both systems showed considerable in vitro activity against S. mansoni, suggesting that these systems may be a promising platform for the administration of PZQ for treating schistosomiasis.","palabras_clave":"Praziquantel|Drug delivery system|Nanostructured lipid carriers|S. mansoni;"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38237,"idioma_id":4,"titulo":"The influence of inertia and contact angle on the instability of partially wetting liquid strips. A numerical analysis study","resumen":"The stability of a thread of fluid deposited on a flat solid substrate is studied numerically by means of the Finite Element Method in combination with an Arbitrary Lagrangian-Eulerian technique. A good agreement is observed when our results are compared with predictions of linear stability analysis obtained by other authors. Moreover, we also analysed the influence of inertia for different contact angles and found that inertia strongly affects the growth rate of the instability when contact angles are large. By contrast, the wave number of the fastest growing mode does not show important variations with inertia. The numerical technique allows us to follow the evolution of the free surface instability until comparatively late stages, where the filament begins to break into droplets. The rupture pattern observed for several cases shows that the number of principal droplets agrees reasonably well   with an estimation based on the fastest growing modes.","palabras_clave":"liquid strips|capillary instability|finite elements|printing applications"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38238,"idioma_id":4,"titulo":"Decoherence: a closed-system approach","resumen":"The fact that the Environment Induced Decoherence approach offers no general criterion to decide where to place the 'cut' between system and environment has been considered as a serious conceptual problem of the proposal. In this letter we argue that this is actually a pseudo-problem, which is dissolved by the fact that decoherence is a phenomenon relative to the relevant observables selected by the measuring arrangement. From this closed-system perspective, certain phenomena alien to the open-system view can be accounted for. ","palabras_clave":"Quantum mechanics|Decoherence|Relaxation|Closed systems"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38239,"idioma_id":4,"titulo":"Partial traces in decoherence and in interpretation: What do reduced states refer to?","resumen":"The interpretation of the concept of reduced state is a subtle issue that has relevant consequences when the task is the interpretation of quantum mechanics itself. The aim of this paper is to argue that reduced states are not the quantum states of subsystems in the same sense as quantum states are states of the whole composite system. After clearly stating the problem, our argument is developed in three stages. First, we consider the phenomenon of environment-induced decoherence as an example of the case in which the subsystems interact with each other; we show that decoherence does not solve the measurement problem precisely because the reduced state of the measuring apparatus is not its quantum state. Second, the non-interacting case is illustrated in the context of no-collapse interpretations, in which we show that certain well-known experimental results cannot be accounted for due to the fact that the reduced states of the measured system and the measuring apparatus are conceived as their quantum states. Finally, we prove that reduced states are a kind of coarse-grained states, and for this reason they cancel the correlations of the subsystem with other subsystems with which it interacts or is entangled. ","palabras_clave":"Reduced state|Partial trace|Environment-induced decoherence|No-collapse interpretation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38240,"idioma_id":4,"titulo":"Assessment of Mycobacterium bovis deleted in p27-p55 virulence operon as candidate vaccine against tuberculosis in animal models","resumen":"A Mycobacterium bovis knockout in p27-p55 operon was tested as an anti-tuberculosis experimental vaccine in animal models. The mutant Mb&#916;p27-p55 was significantly more attenuated in Nude mice than its parental strain but more virulent than BCG Pasteur. Challenge experiments in mice and guinea pigs using M. bovis or M. tuberculosis strains showed similar protection conferred by Mb&#916;p27-p55 mutant than BCG in terms of pathology and bacterial loads in spleen but lower protection than BCG in lungs. When tested in cattle, Mb&#916;p27-p55 did not induce IL-2 expression and induced a very low production of IFN&#947;, suggesting that the lack of P27\/P55 reduces the capacity of M. bovis of triggering an adequate Th1 response.","palabras_clave":"lprg|mycobacterium|vaccine |bovis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38241,"idioma_id":4,"titulo":"A discussion on the origin of quantum probabilities","resumen":"We study the origin of quantum probabilities as arising from non-Boolean propositional-operational structures. We apply the method developed by Cox to non distributive lattices and develop an alternative formulation of non-Kolmogorovian probability measures for quantum mechanics. By generalizing the method presented in previous works, we outline a general framework for the deduction of probabilities in general propositional structures represented by lattices (including the non-distributive case).","palabras_clave":"Quantum probability|Information theory|Lattice theory|R.T.Cox"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38242,"idioma_id":4,"titulo":"Osteoblastic protein tyrosine phosphatases inhibition and connexin 43 phosphorylation by alendronate","resumen":"Bisphosphonates (BPs), potent inhibitors of bone resorption which inhibit osteoclasts, have also been shown to act on osteocytes and osteoblasts preventing apoptosis via connexin (Cx) 43 hemichannels and activating the extracellular signal regulated kinases ERKs. We previously demonstrated the presence of a saturable, specific and high affinity binding site for alendronate (ALN) in osteoblastic cells which express Cx43. However, cells lacking Cx43 also bound BPs. Herein we show that bound [3H]-alendronate is displaced by phosphatase substrates. Moreover, similar to Na3VO4, ALN inhibited the activity of transmembrane and cytoplasmic PTPs, pointing out the catalytic domain of phosphatases as a putative BP target. In addition, anti-phospho-tyrosine immunoblot analysis revealed that ALN stimulates tyrosine phosphorylation of several proteins of whole cell lysates, among which the major targets of the BP could be immunochemically identified as Cx43. Additionally, the transmembrane receptor-like PTPs, RPTPµ and RPTP&#945;, as well as the cytoplasmic PTP1B, are highly expressed in ROS 17\/2.8 cells. Furthermore, we evidenced that Cx43 interacts with RPTPµ in ROS 17\/2.8 and ALN decreases their association. These results support the hypothesis that BPs bind and inhibit PTPs associated to Cx43 or not, which would lead to the activation of signaling pathways in osteoblasts.","palabras_clave":"Alendronate |Osteoblasts |Cx43 hemichannels |Protein tyrosine phosphatases"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38243,"idioma_id":4,"titulo":"Stellar haloes in Milky Way mass galaxies: from the inner to the outer haloes","resumen":"We present a comprehensive study of the chemical properties of the   stellar haloes of Milky Way mass galaxies, analysing the                       transition between the inner to the outer haloes.   We find the transition radius between the relative dominance of the   inner-halo                       and outer-halo stellar populations to be 15-20&nbsp;kpc   for most of our haloes, similar to that inferred for the Milky Way from                       recent observations. While the number density of   stars in the simulated inner-halo populations decreases rapidly with   distance,                       the outer-halo populations contribute about   20-40 per cent in the fiducial solar neighbourhood, in particular at the   lowest                       metallicities. We have determined [Fe\/H] profiles   for our simulated haloes; they exhibit flat or mild gradients, in the   range [-0.002,-0.01] dex\/kpc. The   metallicity distribution functions exhibit different features,   reflecting the different assembly history of the individual                       stellar haloes. We find that stellar haloes formed   with larger contributions from massive subgalactic systems have steeper                       metallicity gradients. Very metal-poor stars are   mainly contributed to the halo systems by lower mass satellites. There   is                       a clear trend among the predicted metallicity   distribution functions that a higher fraction of low-metallicity stars   are found                       with increasing radius. These properties are   consistent with the range of behaviours observed for stellar haloes of   nearby                       galaxies.","palabras_clave":"GALAXY:STRUCTURE|GALAXIES:EVOLUTION|GALAXIES:FORMATION|COSMOLOGY:THEORY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38244,"idioma_id":4,"titulo":"Biochemical characterization of thioredoxin reductase from Babesia bovis","resumen":"This paper addresses the identification, cloning, expression, purification and functional characterization of thioredoxin reductase from Babesia bovis, the etiological agent of babesiosis. The work deals with in vitro steady state kinetic studies and other complementary analyses of the thioredoxin reductase found in the pathogenic protist. Thioredoxin reductase from B. bovis was characterized as a homodimeric flavoprotein that catalyzes the NADPH-dependent reduction of Trx with a high catalytic efficiency. Moreover, the enzyme exhibited a disulfide reductase activity using DTNB as substrate, being this activity highly sensitive to inhibition by Eosin B. The thioredoxin reductase\/thioredoxin system can reduce oxidized glutathione and S-nitrosoglutathione. Our in vitro data suggest that antioxidant defense in B. bovis could be supported by this enzyme.We have performed an enzymatic characterization, searching for targets for rational design of inhibitors. This work contributes to the better understanding of the redox biochemistry occurring in the parasite.","palabras_clave":"Babesia|Eosin B|Nitrosoglutathione|Thioredoxin system|Glutathione disulfide"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38245,"idioma_id":4,"titulo":"Copper tolerance mediated by polyphosphate degradation and low-affinity inorganic phosphate transport system in Escherichia coli","resumen":"Background: Metal tolerance in bacteria has been related to polyP in a model in which heavy metals stimulate thepolymer hydrolysis, forming metal-phosphate complexes that are exported. As previously described in our laboratory,Escherichia coli cells grown in media containing a phosphate concentration >37 mM maintained an unusually highpolyphosphate (polyP) level in stationary phase. The aim of the present work was to evaluate the influence of polyPlevels as the involvement of low-affinity inorganic phosphate transport (Pit) system in E. coli copper tolerance.Results: PolyP levels were modulated by the media phosphate concentration and\/or using mutants in polyPmetabolism. Stationary phase wild-type cells grown in high phosphate medium were significantly more tolerant tocopper than those grown in sufficient phosphate medium. Copper addition to tolerant cells induced polyP degradationby PPX (an exopolyphosphatase), phosphate efflux and membrane polarization. ppk&#8722;ppx&#8722; (unable to synthesize\/degradepolyP), ppx&#8722; (unable to degrade polyP) and Pit system mutants were highly sensitive to metal even in high phosphatemedia. In exponential phase, CopA and polyP-Pit system would act simultaneously to detoxify the metal or one could besufficient to safeguard the absence of the other.Conclusions: Our results support a mechanism for copper detoxification in exponential and stationary phases of E. coli,involving Pit system and degradation of polyP. Data reflect the importance of the environmental phosphate concentrationin the regulation of the microbial physiological state.","palabras_clave":"copper|polyphosphate|phosphate|Escherichia coli"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38246,"idioma_id":4,"titulo":"Hormonal networks involved in apical hook development in darkness and their response to light","resumen":"In darkness, the dicot seedlings produce an apical hook as result of differential cell division and extension at opposite sides of the hypocotyl. This hook protects the apical meristem from mechanical damage during seedling emergence from the soil. In darkness, gibberellins act via the DELLA-PIF (PHYTOCHROME INTERACTING FACTORs) pathway, and ethylene acts via the EIN3\/EIL1 (ETHYLENE INSENSITIE 3\/EIN3 like 1)-HLS1 (HOOKLESS 1) pathway to control the asymmetric accumulation of auxin required for apical hook formation and maintenance. These core pathways form a network with multiple points of connection. Light perception by phytochromes and cryptochromes reduces the activity of PIFs and CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) --both required for hook formation in darkness--, lowers the levels of gibberellins, and triggers hook opening as a component of the switch between heterotrophic and photoautotrophic development. Apical hook opening is thus a suitable model to study the convergence of endogenous and exogenous signals on the control of cell division and cell growth.","palabras_clave":"Arabidopsis|apical hook|photoreceptors|signal transduction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38247,"idioma_id":4,"titulo":"Dynamics of perinatal bovine leukemia virus infection","resumen":"BACKGROUND: Bovine leukemia virus (BLV) is highly endemic in many countries,  including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important to know the pathophysiology of BLV infection in young animals, as they are the main source of animal movement. In this work, we determined the proviral load and antibody titers of infected newborn  calves from birth to first parturition (36  months).  RESULTS: All calves under study were bo  to infected dams with high      proviral load (PVL) in blood and high antibody titers and detectable provirus in  the colostrum. The PVL for five out of seven calves was low at birth. All animals reached PVLs of more than 1% infected peripheral blood mononuclear cells (PBMCs),   three at 3 months, one at 6 months, and one at 12 months. High PVLs persisted  until the end of the study, and, in two animals, exceeded one BLV copy per cell.  Two other calves maintained a high PVL from birth until the end of the study.      Antibody titers were 32 or higher in the first sample from six out of seven  calves. These decayed at 3-6 months to 16 or lower, and then increased again after this point. CONCLUSIONS: Calves infected during the first week of life  could play an active role in early propagation of BLV to susceptible animals,  since their PVL raised up during the first 12 months and persist as high for years. Early elimination could help to prevent transmission to young susceptible animals and to their own offspring. To our knowledge, this is the first study of the kinetics of BLV proviral load and antibody titers in newbo  infected calves.","palabras_clave":"BLV|PERINATAL INFECTION|PROVIRAL LOAD|NATURAL INFECTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38248,"idioma_id":4,"titulo":"Island analysis of low activity dynamic speckles","resumen":"In this work we present a method to evaluate activity in low dynamic speckle patterns. It consists of  binarizing the speckle image and analyzing the displacements and deformations of the resulting  speckle grain regions, here called islands. Numerical simulations and controlled experiments were used  to study the variations of the island features with the aim of finding a correlation with the activity of the  speckle pattern. From the obtained results it was possible to conclude that the developed method can be  useful for the analysis of low activity speckle patterns with the advantage of requiring only pairs of  frames, thus permitting the assessment of nonstationary processes. In the case of stationary phenomena,  so that stacks of frames registers are representative of them, dilute activity images can also be  constructed","palabras_clave":"speckle|interferometria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38249,"idioma_id":4,"titulo":"Susceptibility of larvae of Spodoptera frugiperda and Helicoverpa gelotopoeon (Lepidoptera: Noctuidae) to the entomopathogenic nematode Steinernema diaprepesi (Rhabditida: Steinernematidae) under laboratory conditions","resumen":"Spodoptera frugiperda Smith and Helicoverpa gelotopoeon (Dyar) are important agricultural pests of several crops. The aim of the present work was to evaluate the susceptibility of larvae of both insects to an isolate of Steinernema diaprepesi Nguyen &amp; Duncan under laboratory conditions, as well as the capacity of the nematode to multiply on these lepidoterans. Larvae (n = 15) were exposed to 0 (control), 50, and 100 infective juveniles (IJs) per Petri dish. Mortality was evaluated every 24 h during 6 d, and emerging IJs were counted. Mortality of S. frugiperda was 93% and 100% with 50 and 100 IJs dosage, and 87% and 93% in H. gelotopoeon, respectively. The production of IJs was significantly different between doses (P &#8804; 0.05) for S. frugiperda (11 329 with 50 IJs vs. 27 155 with 100 IJs) but not for H. gelotopoeon (19 830 vs. 26 361, respectively). This is the first study evaluating the susceptibility of these lepidopterans to S. diaprepesi. These resultsencourage the possibility of using this nematode for biological control of both pests.","palabras_clave":"INFECTIVE JUVENILES|BIOLOGICAL CONTROL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38250,"idioma_id":4,"titulo":"Ecological aspects of an isolate of Steinernema diaprepesi (Rhabditida: Steinernematidae) from Argentina","resumen":"        Ecological aspects  of Steinernema diaprepesi isolate SRC  were studied to evaluate the species potential as biological control agent of  insect pests. Under laboratory conditions, the following aspects were  determined: the nematode life cycle, pathogenicity to several arthropods,  reproductive capacity, tolerance to desiccation, effect of temperature on  survival and infectivity of infective juveniles (IJs), and influence of soil  texture and soil water potential on the isolate. The parasitic cycle on  last-instar larvae of Galleria  mellonella at 25 ºC was completed 8 days after infection. The  nematode showed high virulence to lepidopteran larvae, being limited or nil in  the remaining orders of arthropods evaluated. An acceptable offspring  production of S. diaprepesi was  confirmed in the species G. mellonella  and S. frugiperda, suggesting that  the isolate would have potential for control of lepidopteran larvae. Optimum  temperature for reproduction was 20-25ºC. IJs survived exposure to a range of  temperatures between 10 and 40ºC, with a significant reduction in the number of  live IJs at 40ºC.&nbsp; The nematodes remained  infective at 20-40ºC. IJ mortality was 100% on day 6 of exposure to 85% RH. The  movement of IJs observed in the soil column experiments revealed that the  isolate uses a cruiser-type search strategy. Soil texture and water potential significantly  influenced IJ movement, search and penetration of G. mellonella larvae. The efficacy of this isolate was found to be  favoured in sandy soils, regardless of the soil water potential.   ","palabras_clave":"Steinernema diaprepesi|entomopathogenic nematode|ecology|biological control"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38251,"idioma_id":4,"titulo":"Biological evaluation and molecular modelling of didanosine derivatives","resumen":"Five carbonate derivatives of 50-O-20,30-dideoxyinosine (DDI, 1) have been synthesized by combination with aliphatic alcohols, with their in vitro anti-HIV activity and cytotoxicity being evaluated afterward in human peripheral blood mononuclear cells (PBMCs). One particular compound, namely DDI-Penta, exhibited an outstanding performance because it was found to have both a higher inhibitory potency and a lower cytotoxicity than the lead compound, resulting in a 100 enhancement in its selectivity index. In order to further study this phenomenon, the ability of these derivatives to bind to the cytoplasmatic 50-nucleotidase (ncN-II) was studied by in silico methods. Also, the higher calculated lipophilicity of the synthesized compounds was proposed to improve their permeability through the cell membrane since said lipophilicity would allow a higher concentration of the corresponding prodrug inside the infected cell. Overall, a combination of an optimal lipophilicity and the ability of DDI-Penta to bind to ncN-II is suggested due to the higher potency and lower cytotoxicity observed for this compound. Based on the reported findings, we believe that the combination of certain aliphatic alcohols and DDI through a carbonate linkage could significantly increase the performance of this class of therapeutic compounds; therefore, it merits further evaluations.","palabras_clave":"DERIVADOS DE DIDANOSINA|ACTIVIDAD ANTI-HIV|PRODROGAS|MODELADO MOLECULAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38252,"idioma_id":4,"titulo":"Heterologous expression of Arabidopsis ABF4 gene in potato enhances tuberization through ABA-GA crosstalk regulation","resumen":"Potato (Solanum tuberosum L.) tuberization is regulated by many signals, such as abscisic acid (ABA), sucrose and gibberellic acid (GA). ABA and sucrose are positive modulators, while GA is an inhibitor of the process. ABF (ABRE-binding factor) proteins are transcription factors involved in ABA and stress signaling. Previously, we reported that S. tuberosum StABF1 could mediate the ABA effects on tuberization. The aim of the present study was to evaluate the potential use of ABF genes to enhance tuberization and to determine the molecular mechanism involved. For this purpose, transgenic potato plants expressing the Arabidopsis ABF4 or ABF2 genes were generated, and their tuberization capacity and response to tuberization-related signals were analyzed in vitro. The results indicate that both ABF4 and ABF2 proteins positively regulate potato tuber induction; however, only ABF4 expression significantly increases the number and weight of the tubers obtained, without stunting growth. ABF4 and ABF2 transgenic plants exhibit ABA hypersensitivity during tuberization, accompanied by a GA-deficient phenotype. ABF4 expression triggers a significant rise in ABA levels in stolons under tuber-inducing conditions as compared with wild-type plants and a transcriptional deregulation of GA metabolism genes. Our results demonstrate that Arabidopsis ABF4 functions in potato ABA-GA signaling crosstalk during tuberization by regulating the expression of ABA- and GA-metabolism genes. ABF4 gene might be a potential tool to increase tuber production, since its heterologous expression in potato enhances tuber induction without affecting plant growth.","palabras_clave":"ABF\/AREB |ABF2 |ABF4 |Abscisic acid |Gibberellic acid|Potato|Solanum tuberosum |Tuberization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38253,"idioma_id":4,"titulo":"Potential of goat probiotic to bind mutagens","resumen":"The mutagen binding ability of the goat probiotics (Lactobacillus reuteri DDL 19, Lactobacillus alimentarius DDL 48, Enterococcus faecium DDE 39, and Bifidobacterium bifidum DDBA) was evaluated. The oral administration of these probiotics reduced fecal mutagens and intestinal cancer markers in goats. Secondly,the effects of probiotics against the mutagenesis induced by sodium azide (SA), and Benzopyrene(B[a]P) by performing the modified Ames test using Salmonella typhimurium TA 100 was investigated. The capacity to bind benzopyrene and the stability of the bacterialemutagen complex was analyzed by HPLC. The dismutagenic potential against both mutagens was proportional to probiotic concentration.Results showed that probiotic antimutagenic capacity against SA was ranging from 13 to 78%. The mixture of four goat probiotics (MGP) displayed higher antimutagenic activity against SA than any individual strains at the same cell concentration. This study shows that the highest diminution of mutagenicity in presence of B[a]P (74%) was observed in presence of MGP. The antimutagenic activity of nearly all the individual probiotic and the MGP were in concordance with the B[a]P binding determined by HPLC. According to our results, the B[a]P binding to probiotic was irreversible still after being washed with DMSO solution. The stability of the toxic compounds-bacterial cell binding is a key consideration when probiotic antimutagenic property is evaluated. MGP exhibits the ability to bind and detoxify potent mutagens, and this property can be useful in supplemented foods for goats since it can lead to the removal of potent mutagens and protect and enhance ruminal health and hence food safety of consumers.","palabras_clave":"GOAT|PROBIOTIC|BENZOPYRENE|SODIUM AZIDE |ANTIMUTAGENIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38254,"idioma_id":4,"titulo":"Genome-wide data (ChIP-seq) enabled identification of cell wall-related and aquaporin genes as targets of tomato ASR1, a drought stress-responsive transcription factor","resumen":"Background  Identifying the target genes of transcription factors is important for unraveling regulatory networks in all types of organisms. Our interest was precisely to uncover the spectrum of loci regulated by a widespread plant transcription factor involved in physiological adaptation to drought, a type of stress that plants have encountered since the colonization of land habitats 400 MYA. The regulator under study, named ASR1, is exclusive to the plant kingdom (albeit absent in Arabidopsis) and known to alleviate the stress caused by restricted water availability. As its target genes are still unknown despite the original cloning of Asr1 cDNA 20 years ago, we examined the tomato genome for specific loci interacting in vivo with this conspicuous protein.    Results  We performed ChIP followed by high throughput DNA sequencing (ChIP-seq) on leaves from stressed tomato plants, using a high-quality anti-ASR1 antibody. In this way, we unraveled a novel repertoire of target genes, some of which are clearly involved in the response to drought stress. Many of the ASR1-enriched genomic loci we found encode enzymes involved in cell wall synthesis and remodeling as well as channels implicated in water and solute flux, such as aquaporins. In addition, we were able to determine a robust consensus ASR1-binding DNA motif.    Conclusions  The finding of cell wall synthesis and aquaporin genes as targets of ASR1 is consistent with their suggested role in the physiological adaptation of plants to water loss. The results gain insight into the environmental stress-sensing pathways leading to plant tolerance of drought.","palabras_clave":"Tomato|ASR1|ChIP-seq|Water stress|Cell wall|Aquaporin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38255,"idioma_id":4,"titulo":"Twenty years of research on Asr (ABA-stress-ripening) genes and proteins.","resumen":"Investigating how plants cope with different  abiotic stresses?mainly drought and extreme temperatures?  is pivotal for both understanding the underlying  signaling pathways and improving genetically engineered  crops. Plant cells are known to react defensively to mild and  severe dehydration by initiating several signal transduction  pathways that result in the accumulation of different proteins,  sugar molecules and lipophilic anti-oxidants. Among  the proteins that build up under these adverse conditions  are members of the ancestral ASR (ABA-stress-ripening)  family, which is conserved in the plant kingdom but lacks  orthologs in Arabidopsis. This review provides a comprehensive  summary of the state of the art regarding ASRs,  going back to the original description and cloning of the  tomato ASR cDNA. That seminal discovery sparked worldwide  interest amongst research groups spanning multiple  fields: biochemistry, cell biology, evolution, physiology and  epigenetics. As these proteins function as both chaperones  and transcription factors, this review also covers the progress  made on relevant molecular features that account for  these dual roles?including the recent identification of their  target genes?which may inspire future basic research. In  addition, we address reports of drought-tolerant ASR-transgenic  plants of different species, highlighting the influential  work of authors taking more biotechnological approaches.","palabras_clave":"ASR|Water stress|Drought tolerance|Transcription factor|Chaperone"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38256,"idioma_id":4,"titulo":"Potassium - promoted Ce0.65Zr0.35O2 monolithic catalysts for diesel soot combustion","resumen":"This work presents a comparative study of Ce0.65Zr0.35O2 and CeO2 catalysts supported on cordierite forsoot combustion, and the effect of potassium on the catalytic performance. The catalysts were preparedby sequential impregnation over the monolith. The activity in the soot combustion by O2 was studied bysuccessive temperature programmed oxidation cycles, using a loose-contact mode between the soot andthe catalyst. A deactivation was observed after ten cycles of combustion for potassium catalysts. Thisdeactivation was attributed to potassium loss at high temperatures. On the other hand, the catalystswithout K showed activation after the ten soot combustions. When catalysts with the same cerium molarloading were compared, an improvement in the activity of the mixed oxide compared with the pure ceriawas observed. The soot combustion was improved for K\/Ce0.65Zr0.35O2\/cordierite and K\/CeO2\/cordieritewith NO\/O2 presence. However, the catalyst K\/CeO2\/cordierite was still more active. By X-ray diffractionanalyses, it was found that insertion of zirconium into the CeO2 structure took place during preparation.However, a Raman and SEM\/EPMA studies indicated heterogeneity in Ce0.65Zr0.35O2. Domains of cerium?zirconium inside the cordierite channel with a ratio different from the nominal value were observed byscanning electron microscopy analyses. This heterogeneity could decrease the catalytic activity of the cerium?zirconium oxide mixture. The catalytic activity in supported catalysts strongly depends on the effectof Zr, the number of Ce4+\/Ce3+ redox surface sites, the BET area and the structural changes induced byhigh temperatures.","palabras_clave":"diesel|soot|monolith|catalysts"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38257,"idioma_id":4,"titulo":"The evolution of signal-reward correlations in bee and hummingbird-pollinated species of Salvia.","resumen":"Within-individual variation in floral advertising and reward traits is a feature experienced by pollinators that visit different flowers of the same plant. Pollinators can use advertising traits to gather information about the quality and amount of rewards, leading to the evolution of signal?reward correlations. As long as plants differ in the reliability of their signals and pollinators base their foraging decisions on this information, natural selection should act on within-individual correlations between signals and rewards. Because birds and bees differ in their cognitive capabilities, and use different floral traits as signals, we tested the occurrence of adaptive divergence of the within-individual signal?reward correlations among Salvia species that are pollinated either by bees or by hummingbirds. They are expected to use different floral advertising traits: frontal traits in the case of bees and side traits in the case of hummingbirds. We confirmed this expectation as bee- and hummingbird-pollinated species differed in which specific traits are predominantly associated with nectar reward at the within-individual level. Our findings highlight the adaptive value of within-individual variation and covariation patterns, commonly disregarded as ?environmental noise?, and are consistent with the hypothesis that pollinator-mediated selection affects the correlation pattern among floral traits.","palabras_clave":"FLORAL SIGNALS|PHYLOGENETIC COMPARATIVE METHODS|WITHIN-INDIVIDUAL VARIATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38258,"idioma_id":4,"titulo":"Genome sequence of the acid-tolerant strain Rhizobium sp. LPU83","resumen":"Rhizobia are important members of the soil microbiome since they enter   into nitrogen-fixing symbiosis with different legume host plants. Rhizobium sp. LPU83 is an acid-tolerant Rhizobium   strain featuring a broad-host-range. However, it is ineffective in   nitrogen fixation. Here, the improved draft genome sequence of this   strain is reported. Genome sequence information provides the basis for   analysis of its acid tolerance, symbiotic properties and taxonomic   classification.","palabras_clave":"RHIZOBIUM|SEQUENCE|GENOME"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38259,"idioma_id":4,"titulo":"Cultivation-Independent Screening Revealed Hot Spots of IncP-1, IncP-7 and IncP-9 Plasmid Occurrence in Different Environmental Habitats","resumen":"IncP-1, IncP-7 and IncP-9 plasmids often carry genes encoding enzymes involved in the degradation of man-made and natural contaminants, thus contributing to bacterial survival in polluted environments. However, the lack of suitable molecular tools often limits the detection of these plasmids in the environment. In this study, PCR followed by Southern blot hybridization detected the presence of plasmid-specific sequences in total community (TC-) DNA or fosmid DNA from samples originating from different environments and geographic regions. A novel primer system targeting IncP-9 plasmids was developed and applied along with established primers for IncP-1 and IncP-7. Screening TC-DNA from biopurification systems (BPS) which are used on farms for the purification of pesticide-contaminated water revealed high abundances of IncP-1 plasmids belonging to different subgroups as well as IncP-7 and IncP-9. The novel IncP-9 primer-system targeting the rep gene of nine IncP-9 subgroups allowed the detection of a high diversity of IncP-9 plasmid specific sequences in environments with different sources of pollution. Thus polluted sites are ??hot spots?? of plasmids potentially carrying catabolic genes.","palabras_clave":"PLASMID|ENVIRONMENTAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38260,"idioma_id":4,"titulo":"Increased apomixis expression concurrent with genetic and epigenetic variation in a newly synthesized Eragrostis curvula polyploid","resumen":"Eragrostis curvula includes biotypes reproducing through obligate and facultative apomixis or, rarely, full sexuality. We previously generated a 'tetraploid-dihaploidtetraploid' series of plants consisting of a tetraploid apomictic plant (T), a sexual dihaploid plant (D) and a tetraploid artificial colchiploid (C). Initially, plant C was nearly 100% sexual. However, its capacity to form non-reduced embryo sacs dramatically increased over a four year period (2003-2007) to reach levels of 85- 90%. Here, we confirmed high rates of apomixis in plant C, and used AFLPs and MSAPs to characterize the genetic and epigenetic variation observed in this plant in 2007 as compared to 2003. Of the polymorphic sequences, some had no coding potential whereas others were homologous to retrotransposons and\/or proteincoding- like sequences. Our results suggest that in this particular plant system increased apomixis expression is concurrent with genetic and epigenetic modifications, possibly involving transposable elements.","palabras_clave":"APOMIXIS|ERAGROSTIS CURVULA|EPIGENETIC VARIATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38261,"idioma_id":4,"titulo":"Neonization method for stopping, mean excitation energy, straggling, and for total and differential ionization cross sections of CH4, NH3, H2O and FH by impact of heavy projectiles","resumen":"Abstract. We propose a neonization method to deal with molecules composed  by hydrides of the second row of the periodic table of elements: CH4, NH3,OH2, and FH. This method describes these 10-electron molecules as dressedatoms in a pseudo spherical potential. We test it by covering most of the inelasticcollisional magnitudes of experimental interest: ionization cross sections (total,single and double differential), stopping power, energy loss straggling and meanexcitation energy. To this end the neonization method has been treated withdifferent collisional formalisms, such as the continuum-distorted-wave-eikonalinitial-state, the first order Born, and the shell-wise local plasma approximations. We show that the present model reproduces the different empirical values with high reliability in the intermediate to high energy region. We also include the expansion of the spherical wave functions in terms of Slater-type orbitals and the analytic expression for the spherical potentials. This makes it possible in the future to tackle present neonization strategy with other collisional models.","palabras_clave":"neonization|molecules|mean excitation energy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38262,"idioma_id":4,"titulo":"Influence of inner-shell electron removal on the multiple ionization of Kr and Xe by protons","resumen":"The multiple ionization of Kr and Xe by protons has been analysed in detail within the  independent particle model. The dependence of the multiple ionization cross sections on the  values of the ionization probabilities has been investigated for each target subshell and the  most relevant pathways for final quadruple to sextuple ionization are identified. The influence  of post-collisional ionization probabilities due to Auger-like effects after the removal of one or  more inner-shell target electrons has also been considered. It has been observed that, for large  final charge states of the target, deep-core ionization plays an important role, due to the  increase in the number of ejected electrons arising from post-collisional effects.","palabras_clave":"iones|ionizacion multiple|capas internas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38263,"idioma_id":5,"titulo":"Capacidad micotrófi ca y efi ciencia de consorcios con hongos micorrícicos nativos de suelos de la provincia de Buenos Aires con manejo contrastante","resumen":"Se evaluó la capacidad micotrófi ca y de esporulación de consorcios microbianos con hongos micorrícicos arbusculares (HMA) nativos de suelos de la provincia de Buenos Aires (Argentina), y se determinó si las características edáfi cas y los parámetros micorrícicos podrían permitir seleccionar inóculos potencialmente benéfi cos. Se seleccionaron muestras de suelo provenientes de 7 localidades, cada una bajo manejo agrícola (A) y prístino (P). Se instalaron plantas trampa y a las 10 semanas de crecimiento se evidenció colonización micorrícica en la raíces. El número de esporas del suelo de campo fue bajo, mientras que en el sustrato donde crecieron las plantas trampa varió entre 80-1175 esporas\/100 g. El análisis de componentes principales indicó que los contenidos de P y Fe en el suelo fueron los principales moduladores de la capacidad micotrófi ca y de esporulación. Se determinó el potencial micorrícico (PM) de muestras provenientes de tres localidades: Lobería, Junín y Trenque Lauquen. Se verifi có un PM elevado en las muestras provenientes de Lobería con suelo prístino y en las de Trenque Lauquen bajo manejo agrícola, mientras que fue bajo en las de Junín. Finalmente, se evaluó la efi ciencia en condiciones controladas de suelos-inóculo de Lobería bajo manejo agrícola o prístino en plantas de maíz y de tomate. Si bien los incrementos en la materia seca asociados a la inoculación fueron no signifi cativos (p > 0,05), la respuesta micorrícica fue superior al 40 % en tomate y al 25 % en maíz, particularmente con el inóculo proveniente del sitio agrícola. Los bajos incrementos de crecimiento estarían asociados con la incipiente micorrización en ambas especies. Se plantea la necesidad de profundizar los estudios a efectos de determinar los factores involucrados que permitirían seleccionar inóculos eficientes","palabras_clave":"HONGOS|SUELOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38264,"idioma_id":4,"titulo":"The intertropical Brazilian species of Panochthus (Xenarthra: Cingulata: Glyptodontoidea): a reappraisal of their taxonomy and phylogenetic affinities","resumen":"Four species of Panochthus (Panochthus greslebini, Panochthus  jaguaribensis, Panochthus oliveira-roxoi, and Panochthus rochai) have been described for the the late Pleistocene of northeastern Brazil P. oliveira-roxoi, and P. rochai have been considered loosely as synonyms of P. greslebini. This paper reevaluates the referred material, diagnostic characters and validity of these species and includes a cladistic analysis of 25 caudal tube and carapace characters to determine their positioning relative to other species of Panochthus. P. greslebini and P. jaguaribensis are valid species and differ from the other species of Panochthus by unique combinations of caudal tube characters. Carapace fragments previously attributed to P. jaguaribensis are in fact fragments of cephalic shields. These fragments and the isolated ostoderms previously described for P. jaguaribensis cannot be confidently assigned to this species. We support the interpretation of P. rochai as a junior  synonym of P. greslebini, but P. oliveira-roxoi is actually a nomen dubium instead of a synonym of P. greslebini. Our analysis yielded a fully resolved tree in which Panochthini, as traditionally defined, is paraphyletic and the species formerly attributed to Panochthus form a  monophyletic group, echoing recent findings based on a different data base. Within Panochthus the Brazilian species form a clade with the Bonaerian species P. subintermedius, which is the sister species to P. greslebini. Instead of a more basal position suggested in early and recent works, P. jaguaribensis is deeply nested within the clade encompassing the species of Panochthus.","palabras_clave":"Panochthus|Pleistocene|Brazil"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38265,"idioma_id":4,"titulo":"Galerkin boundary elements for a computation of the surface tractions in exterior Stokes flows","resumen":"An indirect boundary integral equation for steady Stokes flow around a rigid body in the three-dimensional space is proposed, and is numerically solved by using collocation and Galerkin weighting procedures. The resulting double surface integrals of the Galerkin technique that express the pairwise interaction among all boundary elements, which are quadruple integrals, are computed on flat  simplex triangles using a regularized quadrature scheme. Numerical examples include the steady creeping flow around the sphere of unit radius and the cube of unit edge length, covering issues on the convergence under mesh refinement and stability under small mesh perturbations.","palabras_clave":"Boundaryintegral methods|Finite-element and Galerkin methods|Collocation methods|Low-Reynolds-number (creeping) flows"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38266,"idioma_id":4,"titulo":"On the type specimen of  Panochthus frenzelianus Ameghino, 1889 (Xenarthra, Glyptodontia, Panochthidae)","resumen":"Panochthus frenzelianus was described by Ameghino in 1889 based on a skull, mandible, cephalic shield, osteoderms from the posteriormost rows of carapace, and caudal rings. Unfortunately, the type specimen was not specified and the provenance and repository of the described specimens were not informed. In 1903, Osborn stated that the holotype of this species was part of a collection of fossil mammals that Cope bought in France in 1878 and later deposited in the AMHN of New York. In 1942, Castellanos published a photograph of the purported holotype of P. frenzelianus (a mounted skeleton) and confirmed that it was deposited at the AMNH, as previously stated by Osborn. However, the specimen presents some differences with the material described in 1889 by Ameghino. Here we attempt to determine the true type specimen of P. frenzelianus and its repository based on information available on the literature, the AMNH collection, archives e.g., notes, catalogs), and on a morphological analysis of some elements assigned to Panochthus housed in that institution. We found that:(1) the specimen figured by Castellanos and exhibited at the AMNH is a composite specimen formed by remains of at least three individuals;(2) these remains do not bear the diagnostic features mentioned by Ameghino and, therefore, they cannot be assigned to the holotype of P. frenzelianus; (3) a cephalic shield and a mandible belonging to another specimen at the AMNH bear the diagnostic characters mentioned by Ameghino, and are the only parts that we could confidently assign to the holotype of P. frenzelianus.","palabras_clave":"Panochthus frenzelianus|holtype|Castellanos|Ameghino"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38267,"idioma_id":4,"titulo":"The rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy","resumen":"                  Glucocorticoids  (GCs) are steroid hormones widely used as coadjuvants in the treatment of solid  tumors due to their anti-inflammatory effects. However, evidence show that they  also may induce chemotherapy resistance, probably through their capacity to  inhibit apoptosis triggered by antineoplastic drugs. GCs exert their action by  regulating gene expression throughout two main mechanisms: transactivation,  where the activated glucocorticoid receptor (GR) directly binds to certain  genes; and transrepression, an indirect mechanism by which GR regulates other  transcription factors activities. Recently, our group has shown that the rigid  steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a selective GR  ligand that behaves as an agonist in transrepression assays and as an  antagonist in transactivation ones. Here, we have evaluated the anti-inflammatory  activity of 21OH-6,19OP, its capacity to generate chemoresistance, as well as  its mechanism of action. We found that 21OH-6,19OP inhibits nitrites formation  and the &nbsp;Inducible nitric oxide synthase  (Nos-2) expression in macrophages. It also blocks the expression of both  cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) triggered by tumor necrosis  factor-alpha (TNF-&#945;)  in epithelial lung cancer cells. However, contrary to dexamethasone (DEX),  21OH-6,19OP neither reverts the paclitaxel-induced caspase-3 activity, nor  induces the anti-apoptotic Bcl-XL gene expression in murine tumor  mammary epithelial cells; and importantly, it lacks GCs-associated chemoresistance  in a mouse mammary tumor model. Together, our findings suggest that 21OH- 6,19OP  behaves as a dissociated GC that keeps anti-inflammatory action without  affecting the apoptotic process triggered by chemotherapeutic drugs. For these  reasons, this steroid may become a putative novel coadjuvant in the treatment  of breast cancer.  ","palabras_clave":"21=H-6,19OP|GR|LM3|apoptosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38268,"idioma_id":4,"titulo":"Non-uremic  calciphylaxis  and  Chagas  disease","resumen":"Calciphylaxis is defined as a syndrome characterized by  calcification of small-vessels, and thrombosis leading to  ischemia of overlying skin together with soft tissue necrosis.  Clinically, patient presents violaceous skin discoloration  in a livedo reticularis pattern, which subsequently become  firm plaques progressing to deep painful necrotic ulcerations,  secondary cutaneous infection and sepsis. Reports on  mortality, usually from sepsis, have been as high as 80%.1  Calciphylaxis has usually been reported in patients with endstage  renal disease or secondary to hyperparathyroidism.  The pathogenesis of this condition is unclear. It is hypothesized  that aberrant calcium---phosphorus metabolism would  lead to calcification of small-vessels, most commonly  observed in uremia-associated metabolic abnormalities. The  increase of calcium---phosphorus product results in vascular  calcification, and subsequent thrombosis of luminal Calciphylaxis is defined as a syndrome characterized by  calcification of small-vessels, and thrombosis leading to  ischemia of overlying skin together with soft tissue necrosis.  Clinically, patient presents violaceous skin discoloration  in a livedo reticularis pattern, which subsequently become  firm plaques progressing to deep painful necrotic ulcerations,  secondary cutaneous infection and sepsis. Reports on  mortality, usually from sepsis, have been as high as 80%.1  Calciphylaxis has usually been reported in patients with endstage  renal disease or secondary to hyperparathyroidism.  The pathogenesis of this condition is unclear. It is hypothesized  that aberrant calcium---phosphorus metabolism would  lead to calcification of small-vessels, most commonly  observed in uremia-associated metabolic abnormalities. The  increase of calcium---phosphorus product results in vascular  calcification, and subsequent thrombosis of luminalnarrowed vasculature promoting end-organ hypoperfusion.2  However, calciphylaxis has also been described in patients  with normal renal and parathyroid function --- non uremic  calciphylaxis (NUC) --- but it is considered extremely rare.  Many factors are associated with the development of NUC,  such as obesity, liver disease, elevated calcium---phosphorus  product, decreased albumin level and systemic corticosteroid  use. Nevertheless, the mechanisms underlying NUC  pathogenesis are not fully understood. Recently, Weenig3  reviewed the role of the predisposing factors and suggested  that the putative risk factors result in increased levels of  pro-inflammatory cytokines TNF-, IL-1, and IL-6 together  with activation of the nuclear factor B, ultimately leading  to vascular calcification.  We describe the first report of calciphylaxis in a patient  seropositive for Chagas disease, which is known to lead to  several immunological disturbances.","palabras_clave":"CALCIPHYLAXIS|NON UREMIC|CHAGAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38269,"idioma_id":4,"titulo":"Chagas disease, a risk factor for high blood pressure","resumen":"Background. Chagas disease is a parasite infection caused by the protozoan Trypanosoma cruzi. Its most common complications is chronic Chagas heart disease but impairments of the systemic vasculature also has been observed. Although the different mechanisms that regulate blood pressure are disrupted, to our knowledge data on the association of hypertension and chronic Chagas disease are scarce. In this regard we evaluate whether Chagas disease constitutes a high blood pressure risk factor. Materials and methods. We recruited 200 individuals, half of them with positive serology for T. cruzi. They were subjected to a complete clinical examination. Results. The mean age of sampled individuals was 46.7 ± 12.3, and the mean of systolic and diastolic blood pressure were 124 ± 12 mmHg and 82 ± 10 mmHg, respectively. There were no between-group differences regarding age, sex distribution or body mass index. Chagas disease contributed significantly to high blood pressure (OR = 4, 95% CI 1.8323?7.0864, p = 0.0002). Conclusion. Our results reveal an important association between Chagas disease and high blood pressure, which should be contemplated by physicians in order to promote preventive cardiovascular actions in patients with Chagas disease.","palabras_clave":"BLOOD PRESSURE|CHAGAS DISEASE|HYPERTENSION|RISK FACTOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38270,"idioma_id":4,"titulo":"Self-tuning digital Mössbauer detection system","resumen":"Long term gamma spectroscopy experiments involving single-channel analyzer equipment depend upon thermal stability of the detector and its associated high-voltage supply. Assuming constant discrimination levels, a drift in the detector gain impacts the output rate, producing an effect on the output spectrum. In some cases (e.g. single-energy resonant absorption experiments) data of interest can be completely lost. We present a digital self-adapting discrimination strategy that tracks emission line shifts using statistical measurements on a predefined region-of-interest of the spectrum. It is developed in the form of a synthesizable module that can be intercalated in the digital processing chain. It requires a moderate to small amount of digital resources and can be easily activated and deactivated.","palabras_clave":"Mössbauer|Instrumentation|Spectrometer|Constant-velocity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38271,"idioma_id":4,"titulo":"Antiradical activity of gallic acid included in lipid interphases","resumen":"Polyphenols are well known as antioxidant agents and by its effects on the hydration layers of lipid interphases. Among them, gallic acid and its family are able to decrease the dipole potential and to act in water as a strong antioxidant. In this work we have studied both effects on lipid interphases in monolayers and bilayers of dimyristoylphosphatidylcholine. The results show that Gallic acid increases the negative surface charges of large unilamellar vesicles (LUVs) and decreases the dipole potential of the lipid interphase. As a result, positively charged radical molecules such as ABTS?+ are able to penetrate the membrane forming an association with GA. These results allow discussing the ARA of GA at the membrane phase which may be taking place in water spaces between the lipids.","palabras_clave":"LIPID MEMBRANES|GALLIC ACID|ANTIOXIDANTS|DIPOLE POTENTIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38272,"idioma_id":4,"titulo":"Metabolic engineering of ammonium release for nitrogen-fixing multispecies microbial cell-factories","resumen":"The biologicalnitrogen fixation carriedoutbysomeBacteriaandArchaeaisoneofthemostattractive alternativestosyntheticnitrogenfertilizers.Inthisstudywecomparedtheeffectofcontrollingthe maximum activationstateofthe Azotobacter vinelandii glutamine synthasebyapointmutationatthe activesite(D49Smutation)andimpairingtheammonium-dependenthomeostaticcontrolofnitrogen- fixation genesexpressionbythe &#916;nifL mutation onammoniumreleasebythecells.Strainsbearing the singleD49Smutationweremoreefficient ammoniumproducersundercarbon\/energylimiting conditions andsustainedmicroalgaegrowthattheexpenseofatmosphericN2 in syntheticmicroalgae? bacteria consortia.Ammoniumdeliverybythedifferentstrainshadimplicationsforthemicroalga´s cell-size distribution.Itwasuncoveredanextensivecrossregulationbetweennitrogen fixation and assimilation thatextendscurrentknowledgeonthiskeymetabolicpathwayandmightrepresent valuablehintsforfurtherimprovementsofversatileN2-fixing microbial-cellfactories.","palabras_clave":"NITROGEN FIXATION|NITROGEN ASSIMILATION|AMMONIUM EXCRETION|FERTILIZER|MICROALGAE BIOMASS|SYNTHETIC CONSORTIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38273,"idioma_id":4,"titulo":"Clinical relevance of galectin-1 expression in non-small cell lung cancer patients","resumen":"AbstractBACKGROUND: Identification of biomarkers in lung cancer, a leading cause ofcancer-related mortality, has a meaningful clinical relevance in the quest ofnovel prognostic factors and therapeutic targets. The glycan-binding proteingalectin-1 (Gal-1) modulates tumor progression by mediating cell-cell andcell-extracellular matrix interactions, as well as angiogenesis and tumorimmune-escape. Previous works reported the expression of Gal-1 in lung cancer, although itsclinical significance remains uncertain.OBJECTIVE: To assess the clinicopathologic relevance and prognostic value of Gal-1expression in a cohort of 103 Stage I-III non-small cell lung cancer (NSCLC)patients.","palabras_clave":"BIOMARKER|GALECTIN-1|IMMUNOHISTOCHEMISTRY|LUNG CANCER|PROGNOSIS|SURVIVAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38274,"idioma_id":4,"titulo":"- Evaporation kinetics in swollen porous polymeric networks.","resumen":"NMR is a fast, nondestructive, and noninvasive technique that can provide information about the pore structure of  macroporous polymer beads and the dynamics of liquids confined in them. In this work, we describe the study of the pore  structure of the macroporous polymer of ethylene glycol dimethacrylate and 2-hydroxyethyl methacrylate [poly(EGDMA-co-  HEMA)] in the dry but also in the swollen state by measuring relaxation times of liquids contained in the polymer network. The  results show that the pore architecture differs from the dry to the soaked state. The behavior of polar liquids during evaporation  and deswelling dynamics is monitored and described. An internal migration of water from the swollen polymer mesh into  expanding pores takes place. With this procedure it is possible to obtain information about the microscopic morphology behavior  of the matrix during evaporation and deswelling. This information is of great interest with the aspect of possible and future  applications for these types of materials.","palabras_clave":"porous|polymers|water absortion|nmr"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38276,"idioma_id":4,"titulo":"Atrazine and Methyl viologen effects on Chlorophyll-a fluorescence revisited. Implications in Photosystems Emission and Ecotoxicity Assessment","resumen":"In this work, we use the effect of herbicides that affect the  photosynthetic chain at dened sites in the photosynthetic  reaction steps to derive information about the uorescence  emission of photosystems. The interpretation of spectral data  from treated and control plants, after correction for light  reabsorption processes, allowed us to elucidate current controversies  in the subject. Results were compatible with the  fact that a nonnegligible Photosystem I contribution to chlorophyll  uorescence in plants at room temperature does exist.  In another aspect, variable and nonvariable chlorophyll  uorescence were comparatively tested as bioindicators for  detection of both herbicides in aquatic environment. Both  methodologies were appropriate tools for this purpose. However,  they showed better sensitivity for pollutants disconnecting  Photosystem II?Photosystem I by blocking the electron  transport between them as Atrazine. Specically, changes in  the (experimental and corrected by light reabsorption) red to  far red uorescence ratio, in the maximum photochemical  quantum yield and in the quantum efciency of Photosytem  II for increasing concentrations of herbicides have been measured  and compared. The most sensitive bioindicator for both  herbicides was the quantum efciency of Photosystem II.","palabras_clave":"Photosystems Emission|herbicides|chlorophyll fluorescence"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38277,"idioma_id":4,"titulo":"Antibacterial Properties of Water-Soluble Gold(I) N-heterocyclic Carbene Complexes","resumen":"The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilutionmethods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coli. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3. ","palabras_clave":"Water-soluble Au(I)|N-heterocyclic carbene|Antibacterial"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38278,"idioma_id":4,"titulo":"Paramagnetic iron-doped hydroxyapatite nanoparticles with improved metal sorption properties. A Bio-organic substrates-mediated synthesis.","resumen":"This paper describes the synthesis of paramegnetic iron-containing hydroxyapatite nanoparticles and their increased Cu2+ sorbent capacity when using Ca2+ complexes of soluble bioorganic substrates from urban wastes as synthesis precursors. A thorough characterization of the particles by TEM, XRD, FTIR spectroscopy, specific surface area, TGA, XPS, and DLS indicates that loss of crystallinity, a higher specific area, an increased surface oxygen content, and formation of surface iron phases strongly enhance Cu2+ adsorption capacity of hydroxyapatite-based materials. However, the major effect of the surface and morphologycal modifications is the size diminution of the aggregates formed in aqueous solutions leading to an increased effective surface available for Cu2+ adsorption. Maximum sorption values of 550?850 mg Cu2+ per gram of particles suspended in an aqueous solution at pH 7 were determined, almost 10 times the maximum values observed for hydroxyapatite nanoparticles suspensions under the same conditions.","palabras_clave":"surface chemistry|magnetic nanomaterials|Cu2+ sorption|effective surface|bioorganic substrates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38279,"idioma_id":4,"titulo":"Waste sourced bio-based substances for solar-driven wastewater remediation: photodegradation of emerging pollutants","resumen":"The effect of soluble bio-based organic substances (SBO) isolated from urban wastes on photochemical wastewater treatments was investigated using a mixture of six emerging pollutants (EPs), namely acetaminophen,caffeine, acetamiprid, clofibric acid, carbamazepine and amoxicillin. Solar simulated experiments showed that although SBO were able to enhance the indirect photolysis of the EPs, they could not compensate for the light screening effect produced by these colored materials. In contrast, SBO were able to enhance photo-Fenton at slightly acidic conditions (pH = 5.2), most probably increasing iron availability.In the later case, the order of reactivity (amoxicillinPcarbamazepine Pclofibric acid > caffeine > acetaminophen > acetamiprid) was similar to that of the rate constants determined for all six EPs with OH. Finally, experiments performed at pilot plant scale with real sunlight at pH = 5.2 and SBO showed that 5 of the EPs were removed in only 25 min and only acetamiprid was more resistant to the process. The overall results show not only how we can use waste to clean out wastes, but also contributeto the studies which show how wastes can become a source of revenue through the industrial exploitation of their chemical value.","palabras_clave":"Wastewater |Sunlight Photolysis |Emerging pollutants |Photo-Fenton"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38280,"idioma_id":4,"titulo":"Chitin hybrid materials reinforced with graphene oxide nanosheets: chemical and mechanical characterisation","resumen":"Chitin hybrid materials reinforced with graphene oxide nanosheets (nGO) have been prepared. The chitin : nGO ratio ranged from proportions where chitin was the main component to ones where nGO exceeded chitin. SEM and TEM images showed that high proportions of nGO may result in nanosheet&lt;br \/&gt;association. FTIR, 13C solid-state NMR and DSC analyses showed that the interaction among the components would not involve the formation of new molecular bonds. nGO was shown to act as a filler that induces structural rearrangements in chitin which lead to new hydrogen bonds among the chains. The mechanical stability proved to be higher when the nGO content in the hybrid was similar to or higher than that of chitin. The rheological behaviour of the material was shown to become more solidlike with increasing nGO content. The nGO did not interfere with lysozyme activity on chitin chains, indicating that these materials would be biodegradable.","palabras_clave":"GRAPHENE OXIDE|NANOSHEETS|CHITIN|COMPOSITE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38281,"idioma_id":4,"titulo":"First harvestman record for the Juan Fernández Archipelago, Chile, with morphological notes on Acropsopilio chilensis (Opiliones: Caddidae: Acroposopilioninae)","resumen":"Acropsopilio chilensis Silvestri, 1904 (Eupnoi: Caddidae: Acropsopilioninae), is recorded for Robinson Crusoe Island, Chile. This is the first harvestman species recorded for the Juan Fernandez Archipelago and also the first extra-continental record for this species. During the comparison with continental co-specific specimens some previously unknown, remarkable morphological characteristics were accessed, among them: the absence of ovipositor seminal receptacles and tracheal system, small and imperforate spiracles and the presence of a subdistal spiny stylus in the major branch of the penis.","palabras_clave":"BIOGEOGRAPHY|ISLAND|ROBINSON CRUSOE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38282,"idioma_id":4,"titulo":"ERROR PROPAGATION IN OPEN RESPIROMETRIC ASSAYS","resumen":"This work deals with the calculation of the uncertainty of the exogenous respiration rate (Rex) and the total oxygen consumed (OCT) derived from a single open respirometric profile. Uncertainties were evaluated by applying a linear error propagation method. Results show that standard deviations (SD) of Rex and OCT depend not only on the SD of the dissolved oxygen (&#963;C) and kLa (&#963;kLa), but also on the SD of the derivative term (dC\/dt) of the oxygen mass balance equation (&#963;b). A Monte Carlo technique was employed to assess &#963;b; a power law expression for the dependence of &#963;b as a function of &#963;C, the time window (tw) and the sampling rate (&#916;t) was proposed. The equations obtained in the present work are useful to calculate suitable conditions (e.g., biomass concentration, kLa) that minimize the coefficient of variation corresponding to Rex and OCT.","palabras_clave":"RESPIROMETRY|ERROR PROPAGATION|RESPIRATION RATE|OXYGEN CONSUMPTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38283,"idioma_id":4,"titulo":"Catalyst reutilization in phenol homogeneous cupro-Fenton oxidation","resumen":"The catalytic wet peroxide oxidation of phenol (1 g\/L) was performed in a laboratory batch reactor using the cupro-Fenton homogeneous reaction. At 70 °C and using 200 mg\/L of Cu (II) complete phenol removal, high TOC reduction (ca. 85%) and efficient use of hydrogen peroxide were achieved. A lumped kinetic model that accounts for organics mineralization and peroxide consumption was developed to predict reactants and total organic carbon profiles. After the reaction step, Cu(II) was recovered by precipitation with NaOH; Cu(II) concentration in the discharged liquid was always less than the 1 mg\/L. The sludge was reused in subsequent reaction steps with minor fluctuations in the catalytic activity. The combination of the cupro-Fenton reaction with an alkaline precipitation procedure allows lower operational costs and helps to reduce the toxicity of the treated wastewater.","palabras_clave":"PHENOL MINERALIZATION|HOMOGENEOUS CUPRO-FENTON|SLUDGE REUTILIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38284,"idioma_id":4,"titulo":"Physical and mechanical properties of compression molded and solution casting soybean protein concentrate based films","resumen":"Soybean protein concentrate-based films plasticized by glycerol were obtained by two processing methods: intensive mixing followed by compression molding and solution-casting. Film forming conditions such as molding temperature, molding pressure, drying conditions as well as glycerol level were determined. The effect of the forming method on the physical and mechanical properties of the resultant films was analyzed in terms of color, light transmission, tensile properties, water solubility and water vapor and oxygen barrier properties. Thermo-pressed soy protein concentrate films were significantly more transparent, less soluble, more stretchable and had lower water vapor permeability but greater oxygen permeability coefficient than solution casting films at the same plasticizer level. These results were associated with the intermolecular forces involved in the formation of the films. Hydrophobic interactions and hydrogen bonding dominated the formation solution-casting films, whereas disulphide bonding played a more important role in the formation of compression molded films, as revealed by solubility of obtained films in denaturing solutions and infrared spectroscopy. This study demonstrates that forming process plays a major role in determining the final properties of soy protein concentrate-based films and reveals the possibility of soy protein concentrate-glycerol mixtures to be transformed through thermo-mechanical processing into biodegradable films with potential application in food packaging.","palabras_clave":"SOYBEAN PROTEIN CONCENTRATE|FILM|COMPRESSION MOLDING|MECHANICAL AND BARRIER PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38285,"idioma_id":4,"titulo":"Synthesis and photodynamic properties of 5,10,15,20-tetrakis[3-(N-ethyl-N-methylcarbazoyl)]chlorin and its analogous porphyrin in solution and in human red blood cells","resumen":"The spectroscopic and the photodynamic properties of 5,10,15,20-tetrakis[3-(N-ethyl-Nmethylcarbazoyl)]chlorin (TEMCC) and its analogous porphyrin (TEMCP) were investigated in N,N-dimethylformamide (DMF) and inhuman red blood (HRB) cells. A more intense absorption band at 650 nm was obtained for TEMCC in comparison with TEMCP. Both photosensitizers showed red fluorescence emission with quantum yields of 0.13 and 0.23 for TEMCP and TEMCC, respectively. The photodynamic activity of TEMCC was higher that TEMCP in DMF, with a quantum yield of singlet molecular oxygen of 0.49. Moreover, in presence of NADH these photosensitizers produced superoxide anion radical.In vitro experiments showed that TEMCC was a highly effective agent to hemolyze the HRB cells. A decrease in the HRB cells osmotic stability was observed after photodynamic treatment with TEMCC. Studies of photodynamic action mechanism showed that the photohemolysis of HRB cells was protected in the presence of azide ion. Also, a reduction on the cell photodamage was found using mannitol. In contrast, the photohemolytic effect considerably increased in D2O. Therefore, the photodynamic activity of TEMCC in HRB cells was mediated by a contribution of type I and type II photooxidative mechanisms.","palabras_clave":"CHLORIN|CARBAZOLE|PHOTODYNAMIC ACTIVITY|ERYTHROCYTES|PHOTOHEMOLYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38286,"idioma_id":4,"titulo":"Crystallographic orientation and electrode nature are key factors for electric current generation by Geobacter sulfurreducens.","resumen":"We have investigated the influence of electrode material and crystallographic structure on electron transfer and biofilm formation ofGeobacter sulfurreducens. Single-crystal gold?Au(110), Au(111), Au(210)?and platinum? Pt(100), Pt(110), Pt(111), Pt(210)?electrodes were tested and compared to graphite rods.G. sulfurreducenselectrochemically interacts with all these materials with different attachment kinetics andfinal current&nbsp; production, although redox species involved in the electron transfer to the anode are virtually the same in all cases. Initial bacterial colonization was fastest on graphite up to the monolayer level, whereas gold electrodes led to higherfinal current densities. Crystal geometry was shown to have an important influence, with Au(210) sustaining a currentdensity of up to 1442 ± 101&#956;Acm &#8722;2 at the steady state, over Au(111) with 961 ± 94&#956;Acm&#8722;2 and Au(110) with 944 ± 89&#956;Acm&#8722;2 . On the other hand, the platinum electrodes displayed the lowest performances, including Pt(210). Our results indicate that both crystal geometry and electrode material are key parameters for the efficient interaction of bacteria with the substrate and should be considered for the design of novel materials and microbial devices to optimize energy production.","palabras_clave":"GEOBACTER|BIOFILMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38287,"idioma_id":4,"titulo":"Intra-host evolution of multiple genotypes of hepatitis C virus in a chronically infected patient with HIV along a 13-year follow-up period","resumen":"The intra-host evolutionary process of hepatitis C virus (HCV) was analyzed by phylogenetic and coalescent methodologies in a patient co-infected with HCV-1a, HCV-2a, HCV-3a and human immunodeficiency virus (HIV) along a 13-year period.Direct sequence analysis of the E2 and NS5A regions showed diverse evolutionary dynamics, in agreement with different relationships between these regions and the host factors.The Bayesian Skyline Plot analyses of the E2 sequences (cloned) yielded different intra-host evolutionary patterns for each genotype: a steady state of a 'consensus' sequence for HCV-1a; a pattern of lineage splitting and extinction for HCV-2a; and a two-phase (drift\/diversification) process for HCV-3a.Each genotype evolving in the same patient and at the same time presents a different pattern apparently modulated by the immune pressure of the host.This study provides useful information for the management of co-infected patients and provides insights into the mechanisms behind the intra-host evolution of HCV.","palabras_clave":"HCV infection|intra host |coalescence|evolution"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38288,"idioma_id":4,"titulo":"Impact of brassinosteroids and ethylene on ascorbic acid accumulation in tomato leaves","resumen":"Plant steroid hormones brassinosteroids (BRs) and the gaseous hormone ethylene   (ET) alter the ascorbic acid - glutathione (AA-GSH) levels in tomato (Solanum   lycopersicum L.) plants. The interaction of these hormones in regulating  antioxidant metabolism is however unknown. The combined use of genetics (BR  mutants) and chemical application (BR\/ET-related chemicals) shows that BRs and ET signalling pathways interact, to regulate leaf AA content and synthesis. BR deficient (dx) leaves display low total AA but BR-accumulating (35S:D) leaves show normal total AA content. Leaves with either BR levels lower or higher than wild type plants showed a higher oxidised AA redox state. The activity of L galactono-1,4-lactone dehydrogenase (L-GalLDH), the mitochondrial enzyme that catalyses the last step in AA synthesis is lower in dx and higher in 35S:D plants. BR-deficient mutants show higher ET production but it is restored to normal levels when BR content is increased in 35S:D plants. Suppression of ET signalling using 1-methylcyclopropene in dx and 35S:D plants restored leaf AA content and L-GalLDH activity, to the values observed in wild type. The suppression of ET action in dx and 35S:D leaves leads to the respective decreasing and increasing respiration, indicating an opposite response compared to AA synthesis. This inverse relationship is lacking in ET suppressed dx plants in  response to external BRs. The modifications in the in vivo activity of L-GalLDH  activity do not correlate with changes in the level of the enzyme. Taken together, these data suggest that ET suppresses and BRs promote AA synthesis and accumulation.","palabras_clave":"Ascorbic acid|Brassinosteroids|Ethylene|Respiration|Tomato"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38289,"idioma_id":4,"titulo":"Conifer fossil woods from the La Meseta Formation (Eocene of Western Antarctica): Evidence of Podocarpaceae-dominated forests","resumen":"A new collection of 120 fossil wood samples from early Eocene sediments of the La Meseta Formation is studied. Conifers represent 68 % of the total amount of wood samples. The specimens show significant conifer diversity and were placed in seven fossil-species. Samples are assigned to the Podocarpaceae, probably Cupressaceae and Araucariaceae. New fossil-species of Protophyllocladoxylon and Phyllocladoxylon (Podocarpaceae) and two new nomenclatural combinations are proposed. Comments about the systematic position of each genus and species represented are made. The systematic is based on anatomical data and supported by statistical analysis. A PCA of 78 woods and 12 characters was performed to confirm the taxon delimitation and discrete clusters are represented in the plots for most of each species. Phyllocladoxylon antarcticum is the most common wood type followed by Cupressinoxylon, Agathoxylon and other Podocarpaceae. In accordance with previous studies, our samples suggest that during the early Eocene forests of the northeastern part of the Antarctic Peninsula were dominated by conifers, particularly Podocarpaceae.","palabras_clave":"fossil woods|Antarctica|Marambio (seymour)|Eocene"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38290,"idioma_id":4,"titulo":"Lateral Motion and Bending of Microtubules Studied with a New  Single-Filament Tracking Routine in Living Cells","resumen":"The cytoskeleton is involved in numerous cellular processes such as migration, division, and contraction and pro- vides the tracks for transport driven by molecular motors. Therefore, it is very important to quantify the mechanical behavior of the cytoskeletal filaments to get a better insight into cell mechanics and organization. It has been demonstrated that relevant mechanical properties of microtubules can be extracted from the analysis of their motion and shape fluctuations. However, tracking individual filaments in living cells is extremely complex due, for example, to the high and heterogeneous background. We introduce a believed new tracking algorithm that allows recovering the coordinates of fluorescent microtubules with ~9 nm precision in in vitro conditions. To illustrate potential applications of this algorithm, we studied the curvature distributions of fluo- rescent microtubules in living cells. By performing a Fourier analysis of the microtubule shapes, we found that the curvatures followed a thermal-like distribution as previously reported with an effective persistence length of ~20 mm, a value significantly smaller than that measured in vitro. We also verified that the microtubule-associated protein XTP or the depolymerization of the actin network do not affect this value; however, the disruption of intermediate filaments decreased the persistence length. Also, we recovered trajectories of microtubule segments in actin or intermediate filament-depleted cells, and observed a signif- icant increase of their motion with respect to untreated cells showing that these filaments contribute to the overall organization of the microtubule network. Moreover, the analysis of trajectories of microtubule segments in untreated cells showed that these filaments presented a slower but more directional motion in the cortex with respect to the perinuclear region, and suggests that the tracking routine would allow mapping the microtubule dynamical organization in cells.","palabras_clave":"MICROTUBULES|INTRACELLULAR DYNAMICS|MOLECULAR MOTORS|TRACKING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38291,"idioma_id":4,"titulo":"Complete Genome Sequences of Lactobacillus Phages J-1 and PL-1","resumen":"Lactobacillus phages J-1 and PL-1 were isolated from abnormal fermentations of Yakult during the 1960´s but genome sequences were still not available. Both genomes are almost identical but PL-1 has a deletion in the genetic switch region and also differs in a gene coding for a putative tail protein.&nbsp;","palabras_clave":"Lactobacillus|Bacteriophage|PL-1|J-1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38292,"idioma_id":4,"titulo":"Carboniferous outcrops at La Herradura Creek, San Juan Province (Western Argentina), revisited: age of the transgressions","resumen":"ABSTRACT. At the outcrops of the Tupe Formation in the La Herradura Creek, San Juan Province, two transgressiveevents are recorded, which range from few meters to tens of meters in thickness. These strata correspond to the stratotypeof the faunal Tivertonia jachalensis-Streptorhynchus inaequiornatus Biozone. An evaluation of the timing of the twomarine transgressions is made on the basis of palynological assemblages and available radiometric ages. A short-livedtransgression is recorded in the latest Bashkirian-early Moscovian, and then a substantial sea level fall took place formingan irregular incision surface. Later, a major high eustatic sea-level occurred during the middle Moscovian resulting in amore important marine ingression. The palynological assemblages associated to the older transgressive event indicatethe presence of the Raistrickia densa-Convolutispora muriornata (DM) Biozone (Subzone B). Palynofloras referred tothe Subzone C of the DM Biozone characterize the strata of the younger transgression that also bear marine fauna ofthe Tivertonia jachalensis-Streptorhynchus inaequiornatus Biozone. Correlations with other Pennsylvanian outcrops inthe region give support to the stratigraphic scheme here proposed.","palabras_clave":"Pennsylvanian|Transgressions|Argentina|Palynology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38293,"idioma_id":4,"titulo":"Strontium ranelate stimulates the activity of bone-specific alkaline phosphatase: interaction with Zn(2+) and Mg (2+).","resumen":"Strontium ranelate (SR) is an orally administered and bone-targeting anti-osteoporotic agent that increases osteoblast-mediated bone forma- tion while decreasing osteoclastic bone resorption, and thus reduces the risk of vertebral and femoral bone fractures in postmenopausal women with osteoporo- sis. Osteoblastic alkaline phosphatase (ALP) is a key enzyme involved in the process of bone formation and osteoid mineralization. In this study we investigated the direct effect of strontium (SR and SrCl2) on the activity of ALP obtained from UMR106 osteosarcoma cells, as well as its possible interactions with the divalent cations Zn2? and Mg2?. In the presence of Mg2?, both SR and SrCl2 (0.05?0.5 mM) significantly increased ALP activity (15?66 % above basal), and this was dose-dependent in the case of SR. The stimulatory effect of strontium disappeared in the absence of Mg2?. The cofactor Zn2? also increased ALP activity (an effect that reached a plateau at 2 mM), and co-incubation of 2 mM Zn2? with 0.05?0.5 mM SR showed an additive effect on ALP activity stimulation. SR induced a dose-dependent decrease in the Km of ALP (and thus an increase in affinity for its substrate) with a maximal effect at 0.1 mM. Co-incubation with 2 mM Zn2? further decreased Km in all cases. These direct effects of SR on osteoblastic ALP activity could be indicating an alternative mechanism by which this compound may regulate bone matrix mineralization.","palabras_clave":"Bone-specific alkaline phosphatase|Magnesium|Zinc|Strontium ranelate|Osteoblasts"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38294,"idioma_id":4,"titulo":"Saxagliptin affects long-bone microarchitecture and decreases the osteogenic potential of bone marrow stromal cells","resumen":"Diabetes mellitus is associated with a decrease in bone quality and an increase in fracture incidence. Additionally, treatment with anti-diabetic drugs can either adversely or positively affect bone metabo- lism. In this study we evaluated: the effect of a 3-week oral treatment with saxagliptin on femoral microarchitecture in young male non-type-2-diabetic Sprague Dawley rats; and the in vitro effect of saxagliptin and\/or fetal bovine serum (FBS), insulin or insulin-like growth factor-1 (IGF1), on the proliferation, differentiation (Runx2 and PPAR-gamma expression, type-1 collagen production, osteo- calcin expression, mineralization) and extracellular-regulated kinase (ERK) activation, in bone marrow stromal cells (MSC) obtained from control (untreated) rats and in MC3T3E1 osteoblast-like cells. In vivo, oral saxagliptin treatment induced a significant decrease in the femoral osteocytic and osteoblastic density of metaphyseal trabecular bone and in the average height of the proximal cartilage growth plate; and an increase in osteoclastic tartrate-resistant acid phosphatase (TRAP) activity of the primary spongiosa. In vitro, saxagliptin inhibited FBS-, insulin- and IGF1-induced ERK phosphorylation and cell proliferation, in both MSC and MC3T3E1 preosteoblasts. In the absence of growth factors, saxagliptin had no effect on ERK activation or cell proliferation. In both MSC and MC3T3E1 cells, saxagliptin in the presence of FBS inhibited Runx2 and osteocalcin expression, type-1 collagen production and miner- alization, while increasing PPAR-gamma expression. In conclusion, orally administered saxagliptin induced alterations in long-bone microarchitecture that could be related to its in vitro down- regulation of the ERK signaling pathway for insulin and IGF1 in MSC, thus decreasing the osteogenic potential of these cells.","palabras_clave":"Bone microarchitecture|Diabetes mellitus|Saxagliptin|Dipeptidyl-peptidase 4|Osteoblasts|Bone marrow stromal cells"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38295,"idioma_id":4,"titulo":"Synthesis, characterization and application of a hexagonal mesoporous silica for pesticide removal from aqueous solution","resumen":"A hexagonal mesoporous silica (SiO 2 ) was hydrothermally synthesized in alkaline media by using mixedcationic cetyltrimethylammonium tosylate-non-ionic Pluronic F68 surfactants as template. Aftercharacterization by commonly used techniques, the solid was evaluated as adsorbent for the remotionof dicationic herbicide paraquat (PQ2+). The adsorption of the PQ2+on SiO 2 has been studied in batchexperiments by performing adsorption isotherms under different conditions of pH, supporting electrolyteconcentration, and temperature. Adsorption kinetic on the studied material has also been carried out anddiscussed. The adsorption of PQ2+on the studied material is strongly dependent on pH, increasing as pHincreases. The adsorption seems to take place by direct binding of the cationic herbicide to SiO 2 activesites (e.g. surface and\/or inside the mesopores) through electrostatic interactions and outer-sphere (orionic pair) complexes formations, as deduce from adsorption experiments at several ionic strengthsand temperatures. The analysis of thermodynamic parameters suggests that the adsorption of PQ 2+ on the studied solid is exothermic and spontaneous in nature. Even after four regeneration cycles throughacid washing, the mesoporous material has still a removal ef&#64257;ciency of ca. 75%, showing a promisingapplication for the treatment of wastewater containing paraquat ions.","palabras_clave":"MCM-41|paraquat adsorption|surface complexes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38296,"idioma_id":4,"titulo":"Phylogeography and genetic structure of two Patagonian  shag species (Aves: Phalacrocoracidae)","resumen":"We compared the phylogeographic and genetic structure of two sympatric  shag species, Phalacrocorax magellanicus (rock shag) and Phalacrocorax atriceps  (imperial shag), from Patagonia (southern South America). We used multilocus  genotypes of nuclear DNA (microsatellite loci) from 324 individuals and mitochondrial  DNA sequences (ATPase) from 177 individuals, to evaluate hypotheses related to  the effect of physical and non-physical barriers on seabird evolution. Despite  sharing many ecological traits, the focal species strongly differ in two key  aspects: P. magellanicus has a strong tendency to remain at\/near their breeding  colonies during foraging trips and the non-breeding season, while P. atriceps exhibits  the converse pattern. Both species showed similar mtDNA genetic structure,  where colonies from the Atlantic Coast, Pacific Coast and Fuegian region were  genetically divergent. We also found similarities in the results of Bayesian  clustering analysis of microsatellites, with both species having four clusters.  However population differentiation (e.g. Fst, Ust) was higher in P.  magellanicus compared to P. atriceps, and average membership probabilities of  individuals to specific clusters (Q-values) were also higher in the former. Phalacrocorax  magellanicus has strong phylogeographic structure, consistent with the impact  of Pleistocene glaciations, with diagnostic haplotypes associated with each of  the three mentioned regions. The same pattern was not as evident for P.  atriceps. Migration rate estimators were higher for P. atriceps than for P.  magellanicus; however both species followed an n-island-like model of gene  flow, this implies that dispersal occurs  across the continental land mass that separates Atlantic and Pacific Oceans.  Our results supported the hypothesis that non-physical barriers are important  drivers of the genetic and phylogeographic structure in seabirds, and also that  physical barriers constitute effective but not absolute impediments to gene  flow.","palabras_clave":"PHYLOGEOGRAPHY|GENETIC STRUCTURE|PHYSICAL BARRIERS|NON-PHYSICAL BARRIERS|GENE FLOW|SEABIRDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38297,"idioma_id":4,"titulo":"The validity of ecogeographical rules is context-dependent: testing for Bergmann's and Allen's rules by latitude and elevation in a widespread Andean duck","resumen":"Consistent responses by various organisms to common environmental pressures represent strong evidence of natural selection driving geographical variation. According to Bergmann´s and Allen´s rules, animals from colder habitats are larger and have smaller limbs than those from warmer habitats to minimize heat loss. Although evidence supporting both rules in different organisms exists, most studies have considered only elevational or latitudinal temperature gradients. We tested for the effects of temperature associated with both elevation and latitude on body and appendage size of torrent ducks (Merganetta armata), a widespread species in Andean rivers. We found a negative relationship between body size and temperature across latitude consistent with Bergmann´s rule, whereas there was a positive relationship between these variables along replicate elevational gradients at different latitudes. Limb-size variation did not support Allen´s rule along latitude, nor along elevation. Highelevation ducks were smaller and had longer wings than those inhabiting lower elevations within a river. We hypothesize that temperature is likely a major selective pressure acting on morphology across latitudes, although hypoxia or air density may be more important along elevational gradients. We conclude that the effect of temperature on morphology, and hence the likelihood of documenting ecogeographical rules, depends on the environmental context in which temperature variation is examined.","palabras_clave":"ADAPTATION|ANDES|BIOGEOGRAPHY|ECOLOGICAL GRADIENTS|MERGANETTA ARMATA|TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38298,"idioma_id":4,"titulo":"Structural Properties of CHAPS Micelles, Studied by Molecular Dynamics Simulations","resumen":"Detergents are essential tools to study biological membranes, and they are frequently used to solubilize lipids and integral membrane proteins. Particularly the nondenaturing zwitterionic detergent usually named CHAPS was designed for membrane biochemistry and integrates the characteristics of the sulfobetaine-type detergents and bile salts. Despite the available experimental data little is known about the molecular structure of its micelles. In this work, molecular dynamics simulations were performed to study the aggregation in micelles of several numbers of CHAPS (&#8804;18) starting from a homogeneous water dilution.The force field parameters to describe the interactions of the molecule were developed and validated. After 50 ns of simulation almost all the systems result in the formation of stable micelles. The molecular shape (gyration radii, volume, surface) and the molecular structure (RDF, salt bridges, H-bonds, SAS) of the micelles were characterized. It was found that the main interactions that lead to the stability of the micelles are the electrostatic ones among the polar groups of the tails and the OH?s from the ring moiety. Unlike micelles of other&nbsp; compounds, CHAPS show a grainlike heterogeneity with hydrophobic micropockets. The results are in complete agreement with the available experimental information from NMR, TEM, and SAXS studies, allowing the modeling of the molecular structure of CHAPS micelles. Finally, we hope that the new force field parameters for this detergent will be a significant contribution to the knowledge of such an interesting molecule.","palabras_clave":"Molecular Dynamics|Molecular Modeling|CHAPS|Micelle Aggregation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38299,"idioma_id":4,"titulo":"Melatonin in testes of infertile men: evidence for anti-proliferative and anti-oxidant effects on local macrophage and mast cell populations","resumen":"AbstractMelatonin acting through the hypothalamus and pituitary regulates testicular function. In addition, direct actions of melatonin at the testicular level have been recently suggested. We have described that melatonin inhibits androgen production in hamster Leydig cells via melatonin subtype 1a (mel1a) receptors and the local corticotrophin-releasing hormone (CRH) system. The initial events of the melatonin\/CRH signalling pathway have also been established. Melatonin and all components of the melatonergic\/CRH system were also detected in Leydig cells of infertile men. This study attempted to search for additional targets of melatonin in the human testis, and to investigate the effects of melatonin on proliferation and the oxidative state in these novel target cells. To this aim, evaluation of human testicular biopsies of patients suffering from hypospermatogenesis or Sertoli cell only syndrome and cell culture studies were performed. Melatonergic receptors were found in macrophages (MACs) and mast cells (MCs) of the human testis. In biopsies of patients suffering idiopathic infertility, melatonin testicular concentrations were negatively correlated with MAC number per mm(2) and TNF&#945;, IL1&#946; and COX2 expression, but positively correlated with the expression of the anti-oxidant enzymes SOD1, peroxiredoxin 1 and catalase. Melatonin inhibited proliferation and the expression of pro-inflammatory cytokines and cyclooxygenase 2 (COX2) in both the human non-testicular THP-1 MAC cell line and primary cell cultures of hamster testicular MACs. In the human HMC-1 MC line, melatonin increased the expression of anti-oxidant enzymes and decreased reactive oxygen species (ROS) generation. The results reveal new testicular targets of melatonin and describe anti-proliferative and anti-inflammatory effects of this hormone on testicular MACs. Furthermore, melatonin might provide protective effects against oxidative stress in testicular MCs.","palabras_clave":"MELATONIN|INFERTILE MAN|ANTI-PROLIFERATIVE|ANTI-OXIDANT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38300,"idioma_id":4,"titulo":"The search for Pleiades in trait constellations: Functional integration and phenotypic selection in the complex flowers of Morrenia brachystephana (Apocynaceae)","resumen":"Pollinator-mediated natural selection on single traits, such as corolla tube or spur length, has been well documented. However, flower phenotypes are usually complex and selection is expected to act on several traits that functionally interact rather than on a single isolated trait. Despite the fact that selection on complex phenotypes is expectedly widespread, multivariate selection modelling on such phenotypes still remains under-explored in plants.     Species of the subfamily Asclepiadoideae (Apocynaceae) provide an opportunity to study such complex flower contrivances integrated by fine scaled organs from disparate developmental origin. We studied the correlation structure among linear floral traits 1) by testing a priori   morphological, functional or developmental hypotheses among traits, and 2) by exploring the organisation of flower covariation, considering alternative expectations of modular organisation or whole flower integration through conditional dependence analysis (CDA) and integration matrices. The phenotypic selection approach was applied to determine whether floral traits involved in the functioning of the pollination mechanism were affected by natural selection.     Floral integration was low, suggesting that flowers are organized in more than just one correlation pleiad; our hypothetical functional correlation matrix was significantly correlated with the empirical matrix, and the CDA revealed three putative modules. Analyses of phenotypic selection showed significant linear and correlational gradients, lending support to expectations of functional interactions between floral traits. Significant correlational selection gradients found involved traits of different floral whorls, providing evidence for the existence of functional integration across developmental domains.","palabras_clave":"SELECTION|ASCLEPIAD|POLLINATION|INTEGRATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38301,"idioma_id":4,"titulo":"Stoichiometric homeostasis in the food web of a chronically nutrient-rich stream","resumen":"The theory of ecological stoichiometry holds that heterotrophs are mostly homeostatic and exhibit  less variation in body stoichiometry than do autotrophs. Most studies of stream foodweb stoichiometry have  been done in low-nutrient environments. Little is known about foodweb stoichiometry in nutrient-rich streams,  in which a higher level of stoichiometric homeostasis should be expected, mainly because imbalances between  resources and consumers are low and nutrient availability may meet biotic requirements. We analyzed elemental  content (C, N, P) and stoichiometric ratios (C&#8758;N, C&#8758;P, N&#8758;P) of basal resources, macroinvertebrates, and fishes  in a nutrient-rich Pampean stream and compared these values to those from other studies. We manipulated P and  N in a 1-y fertilization experiment to analyze biotic stoichiometric responses to additional nutrient input to this  naturally enriched system. Soluble reactive P concentration in the treatment reach was doubled relative to the  background concentration. Consumers had lower C&#8758;P and N&#8758;P than those in other lotic systems, whereas P content  and C&#8758;P and N&#8758;P of basal resources were within the ranges observed for other systems. Most components of  the trophic web were not affected by fertilization, and only epiphyton, fine benthic organic matter, and 2 macroinvertebrate  species (Palaemonetes argentinus and Pomacea canaliculata) changed their nutrient content or stoichiometric  ratios. Imbalances in C&#8758;N and C&#8758;P occurred between primary consumers and their resources, particularly  among macroinvertebrate collectors and detritivorous fishes feeding on FBOM. Most basal resources and consumers  were strictly homeostatic for P content and the stoichiometric ratios, but a lower degree of homeostasis occurred  in the epiphyton, P. canaliculata, and collectors feeding on epiphyton. A high degree of stoichiometric homeostasis  exists across the various components of the food web in this nutrient-rich stream, regardless of their trophic  position.","palabras_clave":"stoichiometry|basal resources|fertilization|macroinvertebrates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38302,"idioma_id":4,"titulo":"Ceramic papers as flexible structures for the development of novel diesel soot combustion catalysts","resumen":"Currently, the most adequate technology for the abatement of particles coming from diesel engines is the one that employs catalytic filters. This work proposes the preparation of catalytic ceramic papers to be employed in the development of new catalytic filters. To this end, the papermaking technique was employed. The resulting papers were flexible, easy to handle and presented suitable mechanical properties to resist the tests from a test bench in which they were placed inside a metal housing, at the exhaust pipe outlet of a Corsa 1.7 vehicle. These optimal mechanical properties were obtained through the incorporation of a suspension of CeO2 nanoparticles during the papermaking process. It was found that the nanoparticles covered the ceramic fibers completely and that their excess accumulated under the form of patches. In order to promote the filter continuous regeneration, once the ceramic papers were formed they were impregnated with a cobalt salt which, after a calcination stage, produced oxidic clusters in tight contact with the CeO2 nanoparticles. The papers thus obtained exhibited a maximum soot combustion temperature close to 400°C, being T50 = 376°C for the more active catalytic ceramic paper, in the presence of NO (1000 ppm) in the feed. Even though more tests are necessary to determine filtration efficiency, preliminary experiments carried out in the test bench proved that the ceramic papers properly resisted the high gas flow rates of fumes emitted by a real diesel engine (approximately 2 m3.min-1). From the TPO experiments performed on samples of catalytic ceramic papers taken from the test bench and in tight contact with the soot retained, it was possible to obtain a maximum soot combustion temperature equal to 428°C. It was also found that the presence of ceria aggregates caused the papers to deactivate to a lesser degree after being treated at 900°C.","palabras_clave":"Ceramic papers|Structured catalysts|Soot removal|Co-Ce catalysts"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38303,"idioma_id":4,"titulo":"?Development of a stacked wire-mesh structure for diesel soot combustion?","resumen":"This work describes the development of stacked wire-mesh structures and their washcoating method to  prepare a structured system for the catalytic combustion of soot. For this purpose, a metallic structured  substrate was designed and built using wire-mesh discs of AISI 304. The coating of this substrate was  optimized by investigating various strategies and parameters of the washcoating such as the suspension  formulation (sol?gel coating with posterior impregnation of the active phase, the all-in-one strategy  using catalyst precursors and the preparation of the catalyst slurry with a ready-made catalyst), the  amount of Co, Ba, K\/CeO2 catalyst and the packing material (wire diameter and number of packed discs).  The coating proposed strategies were analyzed measuring textural properties, catalyst coating adherence  and morphology, and pressure drop of the catalytic substrate. Finally, the coated wire-mesh substrates  were tested in the combustion of soot showing promising catalytic activity","palabras_clave":"WIRE-MESH|STRUCTURED CATALYST|SOOT COMBUSTION|CATALYTIC WASHCOATING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38304,"idioma_id":5,"titulo":"Desarrollo de Habilidades de Comprensión Lectora en Niños de Escuelas de Distintos Sectores Socioeconómicos","resumen":"La comprensión lectora requiere de la decodificación fluida y precisa de las palabras, sin embargo comprender un texto supone un proceso mental de construcción de significados, utilizando una variedad de estrategias que posibilitan la articulación del conocimiento previo con las ideas expresadas en el texto mismo.   La mayoría de los lectores necesita enseñanza explícita sobre las estrategias de comprensión lectora, especialmente aquellos que tienen escasos conocimientos previos y menos dominio de las habilidades lectoras. Muchos pobres comprendedores provienen de sectores socioeconómicos desfavorecidos. A través de la instrucción de dichas estrategias, se podría reducir la brecha producida por un medio ambiente desfavorable.   El objetivo de este trabajo es investigar los efectos del Programa LEE comprensivamente en niños de escuelas de distintos niveles socioeconómico (NSE).  Participaron 100 niños, 47 controles (23 NSE medio y 24 NSE bajo) y 53 del grupo de intervención (28 de NSE medio y 25 NSE bajo) de 9 a 11 años.  Se realizó una evaluación pre-test implementándose luego dos meses de intervención y una evaluación post-test.  En el pre-test, no se encontraron diferencias significativas entre los grupos control e intervención, tanto para el NSE medio como bajo, en las pruebas de comprensión verbal, razonamiento no verbal, lectura de palabras, pseudopalabras y comprensión lectora.  A partir de la aplicación del programa, se observaron mejoras significativas en ambos grupos respecto a sus controles en: vocabulario, comprensión de textos, construcción de inferencias y monitoreo, comprobándose la importancia de la enseñanza explícita de las estrategias y la necesidad del trabajo sistemático sobre los ejes del programa.","palabras_clave":"Intervención|Comprensión Lectora|Vocabulario|Nivel socioeconómico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38305,"idioma_id":4,"titulo":"Preparation and Characterization of Mn-Doped (Ba0.85Ca0.15)(Zr0.1Ti0.9)O3 Ceramics","resumen":"MnO2-doped lead free 0.5[Ba(Zr0.2Ti0.8)O3]-0.5[(Ba0.7Ca0.3)TiO3] ceramics were synthesized by a high-energy ball milling process. We studied the phase formation process along different steps of the mechanical milling. We show that the addition of a small amount of MnO2 (x < 0.5 mol.%) improves the dielectric and ferroelectric properties of the ceramics. It is found that the doping with manganese increases the dielectric constant and reduces the loss, which decreases considerably as the Mn content increases. The remnant polarization of the doped ceramics is increased by 10%.","palabras_clave":"Lead free piezoelectrics|BCZT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38306,"idioma_id":4,"titulo":"Novel Mono- and Dinuclear Complexes of Tricarbonylrhenium(I) with 4-Methyl- 2,2?-bipyridine-4?-carbonitrile","resumen":"Novel mono- and dinuclear tricarbonylrhenium(I) complexes of formula [Re(Mebpy-CN)(CO)3Cl] (1), [Re(Mebpy-CN)-(CO)3(CH3CN)](PF6) (2), and [(CH3CN)(CO)3Re(Mebpy-CN)Ru(NH3)5](PF6)3 (3), in which Mebpy-CN = 4-methyl-2,2-bipyridine-4-carbonitrile, were prepared and characterized by  spectroscopic, photophysical, and computational techniques. The complete structure of complex 2 was determined by X-ray diffraction. The increased conjugation in the bipyridyl ring owing to the nitrile substituent increases the emission quantum yields of the 3MLCT (metal-to-ligand charge-transfer) lowest-lying excited states of 1 and 2 with respect to the corresponding bpy complexes (bpy = 2,2-bipyridine). The mixed-valent species of formula [(CH3CN)(CO)3Re(Mebpy-CN)Ru(NH3)5]4+ (4) was prepared in situ and as a mixed salt; the charge recombination from its metal-to-metal charge-transfer(MMCT) excited state is predicted to lie in the Marcus inverted region. The electronic structures and optical properties of all the reported complexes calculated by DFT and TD-DFT methods agree reasonably well with experimental results.","palabras_clave":"RHENIUM|RUTHENIUM |COORDINATION CHEMISTRY|ELECTRON TRANSFER|DENSITY FUNCTIONAL CALCULATIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38307,"idioma_id":5,"titulo":"Combinación de curado y bicarbonato de sodio para controlar podredumbres en postcosecha de mandarinas sin fungicidas de síntesis","resumen":"Ante la problemática de la resistencia a fungicidas de síntesis de los hongos causantes de podredumbres  en postcosecha, se han evaluado distintos sistemas de control alternativos. Sin embargo, éstos no consiguen  una reducción adecuada de podredumbres sin pérdidas en la calidad de los frutos debido a las dosis  necesarias. El objetivo de este trabajo fue evaluar la combinación de tratamientos de curado (37° C, 90-95%  HR) y bicarbonato de sodio (inmersión) disminuyendo las dosis necesarias para inhibir podredumbres y su efecto adverso sobre la calidad. Para ello, se combinaron tratamientos de 9 ó 18 h de curado (CU9 ó CU18,  respectivamente) con la aplicación de bicarbonato de sodio al 1 ó 2% (Bic1 ó Bic2, respectivamente), para obtener control del moho verde en mandarinas Ellendale inoculadas previamente con Penicillium digitatum, y se  evaluaron las alteraciones en la calidad externa e interna en frutos sin inocular. A su vez, se estudió el control de podredumbres y su efecto sobre la calidad externa e interna de los frutos luego de 7 días a 20º C y, como ensayo confirmatorio, se evaluaron las combinaciones CU9Bic1 y CU9Bic2, simulando una exportación (25  días a 5º C + 7 días a 20º C). Se observó una reducción considerable de podredumbres para los tratamientos  de curado combinados con bicarbonato de sodio, y se confirmó para la combinación de CU9 con bicarbonato luego de la simulación de exportación. Las pérdidas de peso, por su parte, fueron muy bajas pero presentaron  mayores valores que el testigo en los tratamientos de bicarbonato y CU18, mientras que CU9, solo o combinado,  no se diferenció del testigo luego de 7 días a 20º C y fue superior al testigo luego de la exportación pero  sin alcanzar un 5% de deshidratación. Los parámetros de calidad interna y externa no presentaron diferencias entre los tratamientos de CU9 con el testigo, a excepción de un aumento en el contenido de etanol para las  dosis más elevadas luego de la simulación de exportación. - See more at: http:\/\/ria.inta.gov.ar\/?p=5019#sthash.tI9aE1rg.dpuf","palabras_clave":"POSTCOSECHA|CÍTRICOS|CURADO|BICARBONATO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38308,"idioma_id":4,"titulo":"Role of CXCR3\/CXCL10 axis in immune cell recruitment into the small intestine in celiac disease","resumen":"Lymphocytic infiltration in the lamina propria (LP), which is primarily composed of CD4+ Th1 cells and plasma cells, and increased numbers of intraepithelial lymphocytes (IELs), is a characteristic finding in active Celiac Disease (CD). Signals for this selective cell recruitment have not been fully established. CXCR3 and its ligands, particularly CXCL10, were suggested to be one of the most relevant pathways in attracting cells into inflamed tissues. In addition, CXCR3 is characteristically expressed by Th1 cells.  The aim of this work was to investigate the participation of the chemokine CXCL10\/CXCR3 axis in CD pathogenesis.  A higher concentration of CXCL10 was found in the serum from untreated CD patients. mRNA levels for CXCL10 and CXCL11 but not CXCL9 were significantly higher in duodenal biopsies from untreated CD patients compared with non-CD controls or treated patients. CXCL10 was observed to be abundantly produced in untreated CD; the expression of CXCL10 correlated with IFN&#61543; levels in the tissue and was reduced in treated patients. Plasma cells and enterocytes were identified as CXCL10 producer cells. Moreover, CXCL10 expression in intestinal tissues was upregulated by poly I:C or IL-15. IELs, LP T lymphocytes, and plasma cells, which infiltrate major populations in intestinal mucosa in untreated CD, express CXCR3.  The CXCR3\/CXCL10 signalling axis is overactivated in the intestinal mucosa in untreated patients, which explains the specific recruitment of the major cell populations that infiltrate the epithelium, as well as the LP, in CD.","palabras_clave":"celiac disease|chemokines|inflammation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38309,"idioma_id":4,"titulo":"Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation-coagulation interactions","resumen":"The exacerbated disease due to immune- and coagulative-mediated pulmonary injury during acute respiratory viruses infection results in severe morbidity and mortality. Identifying novel approaches to modulate virus-induced inflammation-coagulation interactions could be important alternatives for treating acute respiratory viruses infections. In this study we investigated the effect of the probiotic strain Lactobacillus rhamnosus CRL1505 on lung TLR3-mediated inflammation; and its ability to modulate inflammation-coagulation interaction during respiratory viral infection. Our findings reveal for the first time that a probiotic bacterium is able to influence lung immuno-coagulative reaction triggered by TLR3 activation, by modulating the production of proinflammatory and anti-inflammatory cytokines as wall as expression of tissue factor and thrombomodulin in the lung. We also demonstrated that the preventive treatment with the probiotic bacteria beneficially modulate the fine tune balance between clearing respiratory viruses (respiratory syncytial virus and influenza virus) and controlling immuno-coagulative responses in the lung, allowing normal lung function to be maintained in the face of a viral attack. Our data also pinpoint a crucial role for IL-10 in the immune protection induced by L. rhamnosus CRL1505 during respiratory viral infections. These observations might be helpful to propose new preventive or therapeutic approaches to better control virus-inflammatory lung damage using probiotic functional foods.","palabras_clave":"INFLAMMATION-COAGULATION|Lactobacillus rhamnosus|POLY (I:C)|TLR3|RESPIRATORY SYNCYTIAL VIRUS|INFLUENZA VIRUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38310,"idioma_id":4,"titulo":"A DFT study of dopant (Zr, Nb) and vacancies on the dehydrogenation on MgH2 (001) surface","resumen":"Ab initio calculations were used to study dehydrogenation energy in a set of systems,pure,Nb- or Zr-doped, free of defects and containing vacancy-like defects MgH2(001) surface. The preferential location site for dopants was determined by means of occupation energy analysis. Zr atom   prefers substitutional and interstitial sites while Nb locates on interstitial site close to the surface. The  effect of vacancies in the geometric structure and in dehydrogenation energy was considered. It was   found that MgH2 containing a Mg vacancy doped with Zr, in an interstitial site and the same system containing Mg-H complex vacancy, modify the surface geometry and weakens the Mg-H bonds making easier the dehydrogenation process. When the surface is doped with Nb despite any vacancy generation, the dehydrogenation is less probable energetically in comparison with Zr-doped.","palabras_clave":"MAGNESIUM HYDRIDE|SURFACE| DFT |ELECTRONIC STRUCTURE|DEHYDROGENATION|VACANCIES|DEFECTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38311,"idioma_id":4,"titulo":"A Theoretical Study of the Effect of -Zr, -Nb Doped and Vacancy-like Defects on H Desorption on MgH2 (110) Surface","resumen":"DFT calculations were used to study hydrogen desorption energy in a set of pure, Nb- or Zr-doped systems, containing vacancy-like defects and a MgH2 (110) defect-free surface. The preferential location site for dopants was determined by means of occupation energy analysis. Both transition metal atoms (Nb and Zr) preferred interstitial sites. The effect of vacancies in the systems was also considered. MgH2 with a Nb interstitial atom and MgH2 with a Zr interstitial atom containing a Mg vacancy modifies the surface geometry and weakens the Mg-H bonds thus easing the H desorption process.","palabras_clave":"Hydrogen|Storage|DFT|Magnesium"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38312,"idioma_id":4,"titulo":"Genetically engineered immunomodulatory Streptococcus thermophilus producing antioxidant enzymes show enhanced anti-inflammatory activities","resumen":"The aims of this study were to develop strains of lactic acid bacteria (LAB) having both immunomodulatory and antioxidant properties and to evaluate their anti-inflammatory effects both in vitro, in different cellular models, and in vivo, in a mouse model of colitis. Different Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus strains were cocultured with primary cultures of mononuclear cells. Analysis of the pro- and anti-inflammatory cytokines secreted by these cells after coincubation with candidate bacteria revealed that L. delbrueckii subsp. bulgaricus CRL 864 and S. thermophilus CRL 807 display the highest anti-inflammatory profiles in vitro. Moreover, these results were confirmed in vivo by the determination of the cytokine profiles in large intestine samples of mice fed with these strains. S. thermophilus CRL 807 was then transformed with two different plasmids harboring the genes encoding catalase (CAT) or superoxide dismutase (SOD) antioxidant enzymes, and the anti-inflammatory effects of recombinant streptococci were evaluated in a mouse model of colitis induced by trinitrobenzenesulfonic acid (TNBS). Our results showed a decrease in weight loss, lower liver microbial translocation, lower macroscopic and microscopic damage scores, and modulation of the cytokine production in the large intestines of mice treated with either CAT- or SOD-producing streptococci compared to those in mice treated with the wild-type strain or control mice without any treatment. Furthermore, the greatest anti-inflammatory activity was observed in mice receiving a mixture of both CAT- and SOD-producing streptococci. The addition of L. delbrueckii subsp. bulgaricus CRL 864 to this mixture did not improve their beneficial effects. These findings show that genetically engineering a candidate bacterium (e.g., S. thermophilus CRL 807) with intrinsic immunomodulatory properties by introducing a gene expressing an antioxidant enzyme enhances its anti-inflammatory activities.","palabras_clave":"STREPTOCCOCCUS THERMOPHILUS|CATALASE|SUPEROXIDE DISMUTASE|ANTI-INFLAMMATORY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38313,"idioma_id":4,"titulo":"Macamides from wild 'Maca', Lepidium meyenii Walpers (Brassicaceae)","resumen":"The non-polar extract of the tubers of Lepidium meyenii Walpers yielded two benzylated alkamides (macamides), N-(3,4-dimethoxybenzyl)-hexadecanamide (1) and N-benzyltetracosanamide (2). The structure elucidation of the compounds was based on 1D and 2D NMR spectroscopic analyses, including  1H?1H COSY, 1H?13C HSQC, 1H?13C HMBC, 1H?15N HSQC and HMBC experiments.","palabras_clave":"Lepidium meyenii|maca|macamides|NMR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38314,"idioma_id":4,"titulo":"AN EFFICIENT BIOCATALYTIC SYSTEM FOR FLOXURIDINE BIOSYNTHESIS BASED ON LACTOBACILLUS ANIMALIS ATCC 35046 IMMOBILIZED IN SR-ALGINATE","resumen":"An efficient and green immobilized biocatalyst is herein reported to obtain 5-fluorouracil-2&#8242;-deoxyriboside (5FUradRib), an antimetabolite known as Floxuridine, used in gastrointestinal cancer treatment.    Alginate is a natural polysaccharide used in the pharmaceutical industry due to its physicochemical properties, biocompatibility and non-toxicity. Multivalent cations, exposure time and cross-linking solution concentration were optimized, being Sr2+, 2 h and 0.2 M the best immobilization conditions. Furthermore, compression strength, swelling ratio and fracture frequency were evaluated, improving the mechanical stability of the biocatalyst favoring a future scale-up.    On the other hand, the reaction parameters for 5FUradRib biosynthesis were optimized in order to obtain an immobilized biocatalyst with enhanced activity. Thus, Lactobacillus animalis ATCC 35046 immobilized in Sr-alginate showed yields of 96% at short reaction times.    The obtained biocatalyst was stable for more than 25 days in storage conditions (4 °C) and could be reused at least 10 times without loss of its activity.    Aditionally, Sr-alginate biocatalyst stability was evaluated in different organic solvents to obtain hydrophobic compounds such as 5-bromouracil-2&#8242;-deoxyriboside (5BrUradRib), an effective radiosensitizing agent used in anti-cancer therapy, being hexane the best co-solvent.    Finally, a smooth, cheap and environmentally friendly method to obtain anti-cancer drugs was developed in this study.","palabras_clave":"LACTIC ACID BACTERIA|HALOGENATED 2´-DEOXYRIBOSIDES|STABILIZATION|CO-SOLVENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38315,"idioma_id":4,"titulo":"Stochastic modeling of the NLMS algorithm for complex Gaussian input data and nonstationary environment","resumen":"This paper presents a stochastic model for the normalized least-mean-square (NLMS) algorithm operating under nonstationary environment with complex Gaussian input data. Specifically, model expressions describing the algorithm behavior in both transient and steady-state phases are obtained, allowing therefore a better understanding of how the algorithm parameters affect its performance. The proposed approach avoids several approximations commonly used in the modeling of algorithms with normalized step size, thus giving rise to a very accurate analytical model. Such accuracy is mainly due to the strategy used for computing the normalized autocorrelation-like matrices arising from the model development. Through simulation results, the accuracy of the proposed model is assessed for different operating scenarios.","palabras_clave":"NLMS|modelado|filtro|adaptativo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38316,"idioma_id":4,"titulo":"Tissue-specific variations of esterase activities in the tadpoles and adults of Pseudis paradoxa (Anura: Hylidae)","resumen":"                      We  determined basal levels of cholinesterase (ChE), and carboxylesterase (CbEs;  two substrates: naphthyl acetate and  4-nitrophenylvalerate) in different tissues of tadpoles and adults of the frog Pseudis  paradoxa and evaluated their use as complementary biomarkers of  anti-cholinesterase pesticide exposure.&nbsp; ChE  and CbEs sensitivity to malaoxon was also evaluated. Adults and tadpoleswere collected with sweep net from temporary ponds located in natural  riparian forests along Paraná River (Garay department, Santa Fe  province, Argentina). We found significant differences in B-esterase activities between adults and tadpoles and among different tissues. The in vitro  inhibition tests indicated that ChE is more sensitive to inhibition than CbEs. Our results suggest that basal ChE and CbE (NA and  4-NPV) activities in different tissues of adult and tadpoles P. paradoxa would  be suitable biomarkers of pesticide exposure and this amphibian species could  be used as sentinel in field monitoring.            ","palabras_clave":"Pseudis paradoxa |Biomarker|B-esterase"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38317,"idioma_id":5,"titulo":"Edad,  tamaño corporal de madurez sexual, longevidad y potencial reproductivo de Leptodactylus latinasus y L. mystacinus en un cultivo de soja y un bosque nativo del centro este de Argentina","resumen":"La edad y tamaño corporal de madurez sexual, longevidad y potencial reproductivo en dos especies de anfibios Leptodactylus latinasus y L. mystacinus provenientes de un cultivo de soja (CS) y una reserva natural Parque General San Martín (PGSM) (Entre Ríos-Argentina) fueron estimados y comparados usando técnicas de esqueletocronología. La edad promedio fue diferente entre sitios para L. latinasus (P <0.01). No se observó maduración sexual en L. latinasus en el CS; mientras que en L. mystacinus fue alcanzada a los 3 años en el PGSM y a los 4 años en el CS. Los individuos más jóvenes del PGSM comienzan a reproducirse primeramente respecto de lo observado en el cultivo de soja.","palabras_clave":"Cultivo de soja|Esqueletocronología|Anuros|Longevidad|Madurez sexual"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38318,"idioma_id":4,"titulo":"Superparamagnetic Nanocomposites Obtained by Dispersion of Ultrafine Magnetic Iron Oxide Nanoparticles in Poly(3-hydroxybutyrate)","resumen":"Superparamagnetic nanocomposites were obtained by dispersion of oleic acidcoated  magnetic ultrafine iron oxide nanoparticles (NPs) in poly(hydroxybutyrate) (PHB), a  semicrystalline, biodegradable and biocompatible polymer. Film nanocomposites displayed  an optically homogeneous structure formed by sub-micrometric clusters created by a strong  NPs segregation that occurred during solvent evaporation and polymer crystallization.  Number and size of clusters increased with the concentration of NPs producing a controlled  shift in the blocking temperature but hardly affecting PHB crystallinity and melting  temperature. The presence of NPs decreased the elastic modulus of PHB and slightly  reduced its hardness, leading to materials with improved resistance to permanent damage.  This softening effect was attributed to the oleic acid shell covering the iron oxide core of  the NPs. The present results shed some light on the mechanisms controlling morphology of  semicrystalline-based nanocomposites modified with ultrafine NPs, opening interesting  possibilities for the design of materials with controlled functional properties.","palabras_clave":"BIODEGRADABLE POLYMERS|POLY(HYDROXYBUTYRATE)|SUPERPARAMAGNETIC MATERIALS|NANOCOMPOSITES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38319,"idioma_id":4,"titulo":"Biochemical responses of ecological importance in males of the austral South America amphipod Hyalella curvispina Shoemaker, 1942 exposed to waterborne cadmium and copper","resumen":"The use of physiological parameters as sensitive indicators of toxic stress from exposure to different pollutants is an important issue to be studied. Hyalella curvispina is a Neotropical amphipod often used in ecotoxicological evaluations. This work aimed to quantify biochemical responses of ecological importance in Hyalella curvispina males under stress exposure to sulethal concentrations of waterborne copper (Cu) and cadmium (Cd); in order to obtain basic physiological data as indicators of early effect on this species, on track to its standardization. In order to evaluate the physiological, biochemical and energetic status of the exposed animals, the following endpoints were selected: content of glycogen, total proteins, total lipids, triglycerides, glycerol, arginine, arginine phosphate, levels of lipid peroxidation (TBARS), and Na+\/K+ATPase, catalase (CAT) and superoxide dismutase (SOD) activities. Our results show that the concentrations of Cu (135 and 175 µg\/L) and Cd (6.5 and 10.5 µg\/L) tested altered most of the biochemical variables measured (glycogen, total proteins, total lipids, triglycerides, arginine phosphate, TBARS, and SOD and Na+\/K+ATPase activities). In addition, neither the levels of glycerol and arginine nor CAT activity were affected by exposure to either metal. Energy metabolism was similarly affected both by exposure to Cu and exposure to Cd. The results obtained show the existence of an energy imbalance associated with oxidative damage, suggesting a comprehensive response. This work represents a first contribution of the evaluation of the effect of two heavy metals in some parameters of oxidative stress and energy metabolism of H. curvispina males. The results indicate these parameters can provide a sensitive criterion for the assessment of early ecotoxicological effects of Cu and Cd in laboratory assays, on a native species representative of the zoobenthic and epiphytic communities of South America.","palabras_clave":"Hyalella curvispina|oxidative stress|intermediary metabolism|energy reserves"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38320,"idioma_id":4,"titulo":"The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis","resumen":"Alternative splicing (AS) is tightly coupled to transcription for the majority of human genes. However, how these two processes are linked is not well understood. Here, we unveil a direct role for the transcription factor FBI-1 in the regulation of AS. FBI-1 interacts with the splicing factor SAM68 and reduces its binding to BCL-X mRNA. This, in turn, results in the selection of the proximal 5! splice site in BCL-X exon 2, thereby favoring the anti-apoptotic BCL-XL variant and counteracting SAM68-mediated apoptosis. Conversely, depletion of FBI-1, or expression of a SAM68 mutant lacking the FBI-1 binding region, restores the ability of SAM68 to induce BCL-XS splicing and apoptosis. FBI-1?s role in splicing requires the activity of histone deacetylases, whose pharmacologi- cal inhibition recapitulates the effects of FBI-1 knockdown. Our study reveals an unexpected function for FBI-1 in splicing modula- tion with a direct impact on cell survival.","palabras_clave":"Transcripción|Splicing"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38321,"idioma_id":4,"titulo":"Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis","resumen":"Mitochondria are dynamic organelles that undergo fusion and fission processes. These events are regulated by mitochondria-shaping proteins. Changes in the expression and\/or localization of these proteins lead to a mitochondrial dynamics impairment and may promote apoptosis. Increasing evidence correlates the mitochondrial dynamics disruption with the occurrence of neurodegenerative diseases. Therefore, we focused on this topic in Manganese (Mn)-induced Parkinsonism, a disorder associated with Mn accumulation preferentially in the basal ganglia where mitochondria from astrocytes represent an early target. Using MitoTracker Red staining we observed increased mitochondrial network fission in Mn-exposed rat astrocytoma C6 cells. Moreover, Mn induced a marked decrease in fusion protein Opa-1 levels as well as a dramatic increase in the expression of fission protein Drp-1. Additionally, Mn provoked a significant release of high MW Opa-1 isoforms from the mitochondria to the cytosol as well as an increased Drp-1 translocation to the mitochondria. Both Mdivi-1, a pharmacological Drp-1 inhibitor, and rat Drp-1 siRNA reduced the number of apoptotic nuclei, preserved the mitochondrial network integrity and prevented cell death. CsA, an MPTP opening inhibitor, prevented mitochondrial &#916;&#968;m disruption, Opa-1 processing and Drp-1 translocation to the mitochondria therefore protecting Mn-exposed cells from mitochondrial disruption and apoptosis. The histological analysis and Hoechst 33258 staining of brain sections of Mn-injected rats in the striatum showed a decrease in cellular mass paralleled with an increase in the occurrence of apoptotic nuclei. Opa-1 and Drp-1 expression levels were also changed by Mn-treatment. Our results demonstrate for the first time that abnormal mitochondrial dynamics is implicated in both in vitro and in vivo Mn toxicity. In addition we show that the imbalance in fusion\/fission equilibrium might be involved in Mn-induced apoptosis. This knowledge may provide new therapeutic tools for the treatment of Manganism and other neurodegenerative diseases.","palabras_clave":"Parkinsonism|Apoptosis|Mitochondria|Manganese"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38322,"idioma_id":4,"titulo":"Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors","resumen":"Galectin-8 (Gal-8) is a ?tandem-repeat?-type galectin, which possesses twocarbohydrate recognition domains connected by a linker peptide. Gal-8 complexity isrelated to the alternative splicing of its mRNA precursor, which is known to generateisoforms. Regarding its carbohydrate-binding specificity, Gal-8 has a unique featureamong galectins, since its C-terminal domain has higher affinity for N-glycan-typebranched oligosaccharides, while its N-terminal domain shows strong affinity for beta2-3-sialylated or 3´-sulfated beta-galactosides. We integrate here the available information onGal-8 expression in different tumor types and attempt to elucidate associations of itsexpression and localization with tumor progression with the overarching goal ofanalyzing its potential applications in diagnosis and prognosis. Differential diagnosis isstill a prime concern in tumor pathology, and Gal-8 could be of great value in sometypes of primary or secondary tumors (i.e. papillary thyroid carcinoma, advanced coloncarcinoma from patients with distant metastases, or metastases from primary lungcarcinoma). The prognostic value of Gal-8 has been described for laryngeal carcinomaas well as advanced colon carcinoma. Further studies are needed to explain therelevance of Gal-8 and its isoforms in tumor pathology and their different intra- orextracellular roles (cytoplasmic, nuclear or extracellular) in tumor biology.","palabras_clave":"GALECTINA-8|TUMORES|EXPRESION|LOCALIZACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38323,"idioma_id":4,"titulo":"Expression profile of shelterin components in plasma cell disorders. Clinical significance of POT1 overexpression","resumen":"The core complex of telomere-associated proteins, named the shelterin complex, plays a critical role in telomere protection and telomere length (TL) homeostasis. In this study, we have explored changes in the expression of telomere-associated genes POT1, TIN2, RAP1 and TPP1, in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). A total of 154 patients: 70 with MGUS and 84 with MM were studied. Real-time quantitative PCR was used to quantify gene expression. TL was evaluated by Terminal Restriction Fragments. Our data showed increased expression of POT1, TPP1, TIN2 and RAP1 in MM with respect to MGUS patients, with significant differences for POT1 gene (p=0.002). In MM, the correlation of gene expression profiles with clinical characteristics highlighted POT1 for its significant association with advanced clinical stages, high calcium and &#946;2-microglobulin levels (p=0.02) and bone lesions (p=0.009). In multivariate analysis, POT1 expression (p=0.04) was a significant independent prognostic factor for overall survival as well as the staging system (ISS) (p<0.02). Our findings suggest for the first time the participation of POT1 in the transformation process from MGUS to MM, and provide evidence of this gene as a useful prognostic factor in MM as well as a possible molecular target to design new therapeutic strategies.","palabras_clave":"telomere-associated proteins|myeloma|MGUS|POT1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38324,"idioma_id":4,"titulo":"Glutathione S-transferase gene polymorphisms in celiac disease and their correlation with genomic instability phenotype","resumen":"BACKGROUND AND OBJECTIVE: Genomic instability and reduced glutathione S-transferase (GST) activity have been identified as potential risk factors for malignant complications in celiac disease (CD). In this study, we assessed the possible influence of GST polymorphisms on genome instability phenotypes in a genetically characterised group of celiac patients from previous studies.        METHODS: The deletion polymorphisms in GSTM1 and GSTT1 genes and the single-nucleotide polymorphism GSTP1 c.313A>G were genotyped using PCR in a set of 20 untreated adult patients with a known genomic instability phenotype and 69 age- and sex-matched healthy individuals.        RESULTS: The frequencies of variant genotypes in patients were GSTM1-null (30%), GSTT1-null (5%), GSTP1-AG (60%) and GSTP1-GG (15%), and they showed no differences from controls. No significant differences were found in the genotype distribution based on telomere length. Cases with GSTM1-null genotype (83%) and microsatellite stability were more frequent than those with genomic instability. Moreover, carriers of GSTP1-variant genotype (73%) and stable phenotype were significantly increased compared to unstable patients (27%) (P=0.031). No differences were found according to the clinical-pathological characteristics of celiac cases.    CONCLUSIONS: No association between GST polymorphic variants and celiac-associated genomic instability was proven in our cohort. Future studies should explore the usefulness of other biomarkers to distinguish celiac patients who are susceptible to cancer development.","palabras_clave":"ENFERMEDAD CELIACA|INESTABILIDAD GENÓMICA|GLUTATION-S-TRANSFERASAS|POLIMORFISMOS GENÉTICOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38325,"idioma_id":4,"titulo":"Rheidae Egg Human Exploitation and Stable Isotopes: Trends from West Central Argentina","resumen":"Rheidae eggshells are abundant in the archaeological  record of West Central Argentina. As with many other Ratite species around the  world, the importance of the eggs in human diet was more than the bird meat  itself. Currently, two species inhabit the south and central areas of Argentina  and Chile (Rhea pennata and Rhea americana) with different  geographical distributions and diet, but with similar behavior. In this paper,  we use &#948;13C and &#948;18O isotopes from Rheidae eggshells to explore  the spatial differences in the archaeological record, discuss their importance  in human diet, and as a way to approach human mobility in hunter-gatherer  societies from northern Patagonia. The spatial tendencies of the isotopes´ data  in the archaeological record show a significant correlation between both &#948;13C  as well as &#948;18O isotope data and the Rheidae species´ distribution  in the landscape, showing differences in their diet and territoriality. On the other  hand, the unexpected &#948;13C and &#948;18O isotope values in the Altoandina  desert area suggest human transport of the Rheidae eggs to these locations. The  eggs need to be incorporated in the isotope ecology of the region in order to  understand the human diet. Its signal is not enriched in &#948;13C, but  the variation can be considered in order to improve our understanding of human  diet and mobility. ","palabras_clave":"Ratite diet|human mobility|Stable Isotopes|Suoth América"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38326,"idioma_id":4,"titulo":"Description of immatures of the genus Tropisternus Solier, subgenus Pristoternus Orchymont (Coleoptera: Hydrophilidae), with emphasis on the chaetotaxy and morphometry of larval forms","resumen":"The egg cases, larvae, and pupae of Tropisternus (Pristoternus) latus (Brullé, 1837), T. (P.) ovalis Castelnau, 1840, and T. (P.) laevis (Sturm, 1826) are illustrated and described for the first time. The egg cases are built with or without a mast, which can be ribbon-like or globular; all larval instars have seven anterior denticles in the anterior margin of nasale, and the antennal seta AN8 is present; the pupae bear 6 or 8 styli on the abdominal segments II-VI, the pleural styli can be either short or very long, and horn-like projections may be present on the abdominal segments II-VI. A comparison of the morphology of the egg cases, pupae and larval chaetotaxic and morphometric characters within the genus Tropisternus is presented.","palabras_clave":"WATER SCAVENGER BEETLES|HYDROPHILINAE|LARVA|PUPA|EGG CASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38327,"idioma_id":4,"titulo":"Orientation-dependent response of defective Tantalum single crystals","resumen":"Defective Tantalum monocrystals are expected to display a particularly rich behavior when stressed along different directions. Using molecular dynamics simulations, we model Ta monocrystals containing a single spherical void of different sizes, under uniaxial compression, for two empirical potentials. Differences on the yield point, dislocation generation and plastic heating are observed depending on the void size and stress direction, as distinct slip systems are activated, resulting in a variety of dislocation structures and mobilities.","palabras_clave":"Molecular dynamics|Tantalum|Plasticity|Nanovoids"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38328,"idioma_id":4,"titulo":"Grain size effects in the deformation of [0 0 0 1] textured nanocrystalline Zr","resumen":"Molecular dynamics was used to simulate tensile testing of columnar grain samples of nanocrystalline Zr with random rotationsaround the [0 0 0 1] axis. For grain sizes smaller than a critical size the results show an inverse Hall?Petch effect. For larger grains thecalculated Hall?Petch constant agrees well with the experimental data. Grain size effects on deformation mechanisms, includinggrain boundary sliding and dislocation emission, are also discussed.","palabras_clave":"Zr|Nanocrystalline materials|HallPetch effect"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38329,"idioma_id":4,"titulo":"Shock waves in polycrystalline iron: Plasticity and phase transitions","resumen":"At a pressure of around 13 GPa iron undergoes a structural phase transition from the bcc to the hexagonal close-packed phase. Atomistic simulations have provided important insights into this transition. However, while experiments in polycrystals show clear evidence that the &#945;- transition is preceded by plasticity, simulations up to now could not detect any plastic activity occurring before the phase change. Here we study shock waves in polycrystalline Fe using an interatomic potential which incorporates the &#945;- transition faithfully. Our simulations show that the phase transformation is preceded by dislocation generation at grain boundaries, giving a three-wave profile. The &#945;- transformation pressure is much higher than the equilibrium transformation pressure but decreasesslightly with increasing loading ramp time (decreasing strain rate). The transformed phase is mostly composed of hcp grains with large defect density. Simulated x-ray diffraction displays clear evidence for this hcp phase, with powder-diffraction-type patterns as they would be seen using current experimental setups.","palabras_clave":"Iron|Shocks|Dislocations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38330,"idioma_id":4,"titulo":"High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy","resumen":"Inhibition   of distinct ubiquitin E3 ligases might represent a powerful therapeutic   tool. ITCH is a HECT domain-containing E3 ligase that promotes the   ubiquitylation and degradation of several proteins, including p73, p63,   c-Jun, JunB, Notch and c-FLIP, thus affecting cell fate. Accordingly,   ITCH depletion potentiates the effect of chemotherapeutic drugs,   revealing ITCH as a potential pharmacological target in cancer therapy.   Using high throughput screening of ITCH auto-ubiquitylation, we   identified several putative ITCH inhibitors, one of which is   clomipramine - a clinically useful antidepressant drug. Previously, we   have shown that clomipramine inhibits autophagy by blocking   autophagolysosomal fluxes and thus could potentiate chemotherapy in   vitro. Here, we found that clomipramine specifically blocks ITCH   auto-ubiquitylation, as well as p73 ubiquitylation. By screening   structural homologues of clomipramine, we identified several ITCH   inhibitors and putative molecular moieties that are essential for ITCH   inhibition. Treating a panel of breast, prostate and bladder cancer cell   lines with clomipramine, or its homologues, we found that they reduce   cancer cell growth, and synergize with gemcitabine or mitomycin in   killing cancer cells by blocking autophagy. We also discuss a potential   mechanism of inhibition. Together, our study (i) demonstrates the   feasibility of using high throughput screening to identify E3 ligase   inhibitors and (ii) provides insight into how clomipramine and its   structural homologues might interfere with ITCH and other HECT E3 ligase   catalytic activity in (iii) potentiating chemotherapy by regulating   autophagic fluxes. These results may have direct clinical applications.","palabras_clave":"HECT Domain|ITCH|E3 ligase|Ubiquitin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38331,"idioma_id":4,"titulo":"'Phosphate adsorption on goethite and Al-rich goethite'","resumen":"The adsorption of phosphate complexes on pure and Al-rich goethite surfaces was studied by using density  functional theory (DFT) and a periodic slab model. Several phosphate complexes are evaluated on these surfaces, which were not studied in other earlier theoretical works. The following complexes have  been considered: bidentate binuclear (BB), bidentate mononuclear (BM), monodentate mononuclear  (MM) and monodentate binuclear (MB), with their respective mono-protonated and non-protonated species.  Our calculations indicate that the formation of all these species is possible on both goethite surfaces.  Particularly, the direct correlation between calculated vibrational frequencies of phosphate complexes on  pure goethite and experimental results indicates that some specific species are formed at certain pH values.  For these cases we are able to provide an alternative interpretation to the experimental bands. On the  other hand, the obtained vibrational frequencies of phosphate adsorbed on Al-goethite can be useful for  the forthcoming experimental results. We noticed that the band shifts are extremely dependent on the  kind of pretreated samples; for this reason the surface model used in calculations establishes restrictions on the IR experimental results to be compared.","palabras_clave":"Phosphate adsorption|Goethite|Al-goethite|Periodic DFT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38332,"idioma_id":5,"titulo":"La recepción en Rosario de la experiencia franquista y el desarrollo español a través de la prensa, la universidad y la gestión pública, 1958-1962.","resumen":"Revista indexada en LATINDEX, REDIB, III, DOAJ, CIT, MIAR Y LATAM. Asimismo en ESCI de WoS.  La restauración 'liberal' que siguió a la experiencia peronista, a partir de septiembre de 1955, dispuso en la ciudad de Rosario del control hegemónico de los seis periódicos que por entonces allí se editaban. El relevamiento de los mismos otorga la posibilidad del proceso de instalación de un discurso en relación con la interpretación y recepción de modelos internacionales de desarrollo. En esta ponencia se aborda la visión que los mismos presentaron sobre la realidad de la España del desarrollo, tanto lo que se refiere a su relación con los gobiernos argentinos, como a la difusión de las actividades de los exiliados de la guerra civil en Rosario, las manifestaciones antifranquistas organizadas por las instituciones locales y las propias autoridades municipales, analizando asimismo las posturas asumidas en el ámbito universitario y en particular, de aquellos que tendrán actuación en la función pública en tiempos del desarrollismo. De esta manera se pretende contextualizar la diferencia de matices entre la postura del presidente Arturo Frondizi, que visitó España en 1960 en el marco de la recomposición de las relaciones entre ambos países; y la del gobierno de la provincia de Santa Fe, que a último momento decidió no incluir a España en la gira que el ministro de Hacienda, Juan Quilici, realizó en el marco de su gira europea de 1961. Asimismo en la ponencia se detecta la acción local de sectores pro franquistas, así como el despliegue de la política cultural exterior del franquismo, que se traducirá en un mayor fomento de las becas de perfeccionamiento del Instituto de Cultura Hispánica -con un promedio de 200 plazas anuales para Iberoamérica a partir de 1957-, lo que por otra parte permite vislumbrar la constitución de nuevas redes que incidirán en los vínculos bilaterales a partir de mediados de la década del 60. La ponderación de estos factores, pretende contribuir en la caracterización de aquella etapa inicial de la difusión exterior del modelo franquista de desarrollo, y del caso español como un factor de 'prueba de demostración' de recetas para el 'occidente' Iberoamericano.","palabras_clave":"ROSARIO|DESARROLLISMO|UNIVERSIDAD|ESPAÑA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38333,"idioma_id":4,"titulo":"Skull allometry and sexual dimorphism in the ontogeny of the Southern elephant seal (Mirounga leonina)","resumen":"The Southern  elephant seal, Mirounga leonina (Linneaus  1758), is one of the most dimorphic mammals but sexual dimorphism in  its skull ontogeny is poorly known. We  study ontogeny of sexual dimorphism (SD) by the allometric relationships  between 21 measurements and its geometric mean. Based on 66 specimens (36  females, 30 males), the bivariate and multivariate analyses indicated that both  approaches were congruent in most variables. We detected that SD was reached mostly by sexual shape  differences in the ontogenetic trajectories of males and females. 24% of  variables were associated with intercepts differences (pup size proportions),  while 57% of variables were associated with slope intersexual differences  (relative growth rates). Contrarily, SD was also achieved by size differences  in adult stages (19% of variables), as males exhibited an extension of their common  ontogenetic trajectories. Secondary growth spurt in males was detected for few  variables. Our comparison with analogous data collected on Otaria byronia (de Blainville 1820), the  southern sea lion, indicate that in both species SD was mostly pointed to an  enhanced ability to defend territories, which was linked to with the polygynic  behavior. However, discrepancies between both ontogenetic patterns of  dimorphism were associated with interspecific differences in their life cycles.","palabras_clave":"Mirounga  leonina|southern  elephant  seal|Otaria  byronia|allometric growth|cranium|morphometry|growth rate|pinniped"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38334,"idioma_id":4,"titulo":"Nutraceutical Properties and Toxicity  Studies of Flour Obtained from Capsicum pubescens Fruits and Its Comparison with ?Locoto? Commercial Powder","resumen":"The aim of this research was to evaluate the phytochemical profiles of flour from red, yellow and green fruits of Capsicum pubescens (commun name: locoto) and compare with ?locoto? commercial powder (Lcp). Soluble protein (SP), total sugar (TS), free phenolic compounds (FPC), ascorbic acid (AA), total monomeric anthocyanin (TMA), condensed and hydrolizable tannin (CT, HT) and carotenoids (C) were determined by spectrophotometric methods. Multielemental composition by ICP-MS was also done. The flour showed low amounts of calories and high potassium and low sodium levels. Flour from ?locoto? fruits contained mainly carotenoids (0.82 to 20 g Eâ-C\/100g DW), polyphenolic compounds (681 - 822 mg GAE\/100g DW) and ascorbic acid (100 - 199 mg AA\/100g DW). The polyphenolic profile of Lcp was similar to flour obtained in our laboratory but the level of carotenoid was lower than that of flour. The fiber content of flour was around 3% in all cases. All preparations obtained from flour and Lcp showed antioxidant activity with SC50 values be&nbsp;tween 1.4 and 3 ìg GAE\/mL. Inhibitory capacity on Lipo-oxygenase enzyme was also demonstrated. Non mutagenic effect was detected. The ?locoto? flour showed nutraceutical characteristics that are demanded by functional food and could be used as a dietary supplement.&nbsp;","palabras_clave":"Locoto Fruit; ;; ; |Locoto |Flour| Capsicum pubescens|Nutritional Properties|Functional Propertie"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38335,"idioma_id":4,"titulo":"Phytochemical composition and antioxidant capacity of Psidium guajava fresh fruits and flour","resumen":"Psidium guajava fruits are consumed fresh or processed (beverages, syrup, ice cream, jams and jellies). Guayaba is a fruit highly perishable and susceptible to damage during the postharvest. One strategy to overcome this problem is its processing by using techniques that preserve its organoleptic, nutritive and functional properties and allow getting food with added value. The purpose of this study was to obtain flour from fresh fruits cultivated in Argentina Northwestern by lyophilization and to determine the antioxidant activity and the main phytochemicals present in fresh fruits and flour. Nutritional composition (sugar, protein and fat) and the bioactive phytochemicals (total phenolic compounds, flavonoid phenolic, condensed and hydrolizable tannin, ascorbic acid, pigments such as anthocyanin and carotenoids) as well as fiber content, were evaluated. The flour preserved flavor, aroma and color of pulp from fresh fruits. The flour contained around 30% of sugar, 20% of total protein, 0.5% of fat and high level of crude fiber. Carotenoids and ascorbic acid were the dominant phytochemicals in flour as well as in fresh fruits. The guayaba flour showed antioxidant activity with SC50 values similar to fresh fruits. The flour showed nutraceutical characteristics that are demanded by functional food and could be used as a dietary supplement.","palabras_clave":"FRESH FRUIT|FLOUR|PSIDIUM GUAJAVA |NUTRITIONAL PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38336,"idioma_id":5,"titulo":"La proyección nacional del desarrollismo santafesino entre 1962 y 1972 Juan Quilici al frente de la cartera de Hacienda del presidente Lanusse y de la Comisión de Coordinación Latinoamericana en 1971","resumen":"REVISTA INDIZADA EN LATINDEX, GUIA UICyT, y CAYCIT. Juan Quilici, ministro de Hacienda de la provincia de Santa Fe durante la gestión de Carlos Sylvestre Begnis, 1958-1962, formó parte del grupo de ex funcionarios que siguiendo al gobernador derrocado mostraron su disidencia con la conducción nacional del Movimiento de Integración y Desarrollo (MID) procurándose un espacio propio en el territorio provincial y en la política argentina entre 1962 y 1972. En el transcurso de esa década, la más explícita actuación en el gobierno se produjo cuando Quilici, 'el economista' de Sylvestre Begnis, se desempeñó durante la Revolución Argentina como titular de la cartera de Hacienda de la presidencia del general Alejandro A. Lanusse desde el 23 de abril de 1971 y por espacio de dos meses. En esta ponencia se analizan las principales medidas adoptadas durante ese breve pero intenso desempeño ministerial, detectando la presencia de elementos del discurso desarrollista santafesino en materia de reversión de las asimetrías regionales, y la participación de Quilici como organizador y presidente de la Comisión Especial de Coordinación Latinoamericana (CECLA), impulsada por el presidente Lanusse para hacer frente a la decisión de los Estados Unidos de aumentar los aranceles a los productos exportados a ese país desde América Latina.","palabras_clave":"HISTORIA|ECONOMIA|ARGENTINA|SANTA FE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38337,"idioma_id":4,"titulo":"The levels of RAC3 expression are up regulated by TNF in the inflammatory response","resumen":"RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-jB (NF-jB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investi-gated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflammation regulates RAC3 levels. In mice, sub-lethal doses of lipopolysac-charide induce the increase of RAC3 in spleen and the administration of the synthetic anti-inflam-matory glucocorticoid dexamethasone has a similar effect. However, the simultaneous treatment with both stimuli is mutually antagonistic. In vitro stimulation of the HEK293 cell line with tumor necrosis factor (TNF), one of the cytokines induced by lipopolysaccharide, also increases the levels of RAC3 mRNA and protein, which correlates with an enhanced transcription dependent on the RAC3 gene promoter. We found that binding of the transcription factor NF-jB to the RAC3 gene promoter could be responsible for these effects. Our results suggest that increase of RAC3 during the inflam-matory response could be a molecular mechanism involved in the control of sensitivity to both pro-and anti-inflammatory stimuli in order to maintain the normal healthy course of the immune response. ","palabras_clave":"RAC3|Glucocorticoids|TNF|NF-kB"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38338,"idioma_id":4,"titulo":"New alginic acid-atenolol microparticles for inhalatory drug targeting","resumen":"En este trabajo he participado como colaboradora, asistiendo en la utilización de los equipos Buchi B290 y Horiba LA 950 que están bajo mi cargo, ademas preste colaboración para la puesta a punto de la técnica para medición de tamaño de partícula, en la preparación de muestras para DSC, en la compra de materiales y solicitudes de uso de los demás equipos.","palabras_clave":"INHALATORY DRUG|ALGINIC ACID|ATENOLOL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38339,"idioma_id":4,"titulo":"NATAMYCIN AND NISIN SUPPORTED ON STARCH EDIBLE FILMS FOR CONTROLLING MIXED CULTURE GROWTH ON MODEL SYSTEMS AND PORT SALUT CHEESE","resumen":"Consumer demand for natural food additives has increased and, as a consequence, the use of natural antimicrobials like natamycin and nisinis being investigated. In the case of cheese, surface colonization by microorganisms constitutes a significant risk to consumer´s health. In this study, the effectiveness of natamycin and nisin supported in tapioca starch films against Saccharomyces cerevisiae and Listeria innocua in a mixed culture present on the surface of a model system and of Port Salut cheese was evaluated. It was observed that the preservatives incorporated in starch films, controlled growth of both microorganisms present together on the surface of the cheese during storage. Additionally, the joint presence of nisin and natamycin was effective as a barrier against a mixed culture preventing an external contamination of cheese and of a model system, during storage. Hence, this film has great potential to be used as antimicrobial edible packaging.","palabras_clave":"NATAMYCIN | NISIN|EDIBLE FILMS|CHEESE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38340,"idioma_id":4,"titulo":"Comparison of tide model outputs for the northern region of the Antarctic Peninsula using satellite altimeters and tide gauge data","resumen":"This study compares the common harmonic constants of the O1, K1, P1, Q1, M2, S2, N2, and K2 tidal constituents from eight global and four regional tide models with harmonic constants from satellite altimeter and tide gauge data for the northern region of the Antarctic Peninsula (58°S-66°S, 53°W-66°W). To obtain a more representative comparison, the study area was divided into three zones with different physical characteristics but similar maximum tidal amplitude variations: Zone I (north of 62°S), Zone II (south of 62°S and west of the Antarctic Peninsula), and Zone III (between 62°S and 64.3°S, and east of 58.5°W). Root sum square (RSS) values are less than or equal to 3.0, 4.2, and 8.4cm for zones I, II, and III, respectively. No single model shows superior performance in all zones. Because there are insufficient satellite altimetry observations in the vicinity of Matienzo Base (64.9761°S, 60.0683°W), this station was analyzed separately and presents the greatest values of both root mean square misfit and RSS. The maximum, minimum, and average amplitude values of the constituents that follow in importance after the eight common tidal constituents, and which have amplitudes greater than 1cm, are also analyzed. © 2013 Elsevier B.V. and NIPR.","palabras_clave":"SEA SURFACE HEIGHT|TIDE MODELLING|ANTARTIC PENINSULA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38341,"idioma_id":4,"titulo":"Digital electronics for the Pierre Auger Observatory  AMIGA muon counters","resumen":"The 'Auger Muons and Infill for the Ground Array' (AMIGA) project provides direct muon counting capacity to the Pierre Auger Observatory and extends its energy detection range down to 0.3 EeV. It currently consists of 61 detector pairs (a Cherenkov surface detector and a buried muon counter) distributed over a 23.5 km2 area on a 750 m triangular grid. Each counter relies on segmented scintillator modules storing a logical train of `0´s and `1´s on each scintillator segment at a given time slot. Muon counter data is sampled and stored at 320 MHz allowing both the detection of single photoelectrons and the implementation of an offline trigger designed to mitigate multi-pixel PMT crosstalk and dark rate undesired effects. Acquisition is carried out by the digital electronics built around a low power Cyclone III FPGA. This paper presents the digital electronics design, internal and external synchronization schemes, hardware tests, and first results from the Observatory.","palabras_clave":"Digital electronic circuits|Particle detectors|Data acquisition circuits"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38342,"idioma_id":4,"titulo":"EFFECT OF NATAMYCIN, NISIN AND GLYCEROL ON THE PHYSICOCHEMICAL PROPERTIES, ROUGHNESS AND HYDROPHOBICITY OF TAPIOCA STARCH EDIBLE FILMS","resumen":"In this paper, films based on tapioca starch and containing nisin, natamycin and glycerol were characterized in relation to their physicochemical properties, roughness and hydrophobicity. The content of glycerol affected the mechanical properties of the films studied and the roughness and it was observed an increase in WVP with the increase in glycerol content. The addition of antimicrobials affected the mechanical properties, being nisin the one that produced the greater decrease in the Young modulus. The color was highly affected by the joint presence of natamycin and nisin, which increased the yellow index. The contact angle increased with antimicrobial addition indicating a decrease in hydrophilicity. Nisin also affected the roughness of the films. Water vapor permeability was slightly reduced by the presence of natamycin. It was observed that water vapor permeability and contact angle were correlated with the roughness of the films.","palabras_clave":"starch|natamycin and nisin|physicochemical properties|hydrophobicity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38343,"idioma_id":4,"titulo":"Modulation of mammalian circadian rhythms by Tumor Necrosis Factor-&#945;","resumen":"Systemic low doses of the endotoxin lipopolysaccharide (LPS, 100&#8201;µg\/kg) administered during the early night induce phase-delays of locomotor activity rhythms in mice. Our aim was to evaluate the role of tumor necrosis factor (Tnf)-alpha and its receptor 1\/p55 (Tnfr1) in the modulation of LPS-induced circadian effects on the suprachiasmatic nucleus (SCN). We observed that Tnfr1-defective mice (Tnfr1 KO), although exhibiting similar circadian behavior and light response to that of control mice, did not show LPS-induced phase-delays of locomotor activity rhythms, nor LPS-induced cFos and Per2 expression in the SCN and Per1 expression in the paraventricular hypothalamic nucleus (PVN) as compared to wild-type (WT) mice. We also analyzed Tnfr1 expression in the SCN of WT mice, peaking during the early night, when LPS has a circadian effect. Peripheral inoculation of LPS induced an increase in cytokine\/chemokine levels (Tnf, Il-6 and Ccl2) in the SCN and in the PVN. In conclusion, in this study, we show that LPS-induced circadian responses are mediated by Tnf. Our results also suggest that this cytokine stimulates the SCN after LPS peripheral inoculation; and the time-related effect of LPS (i.e. phase shifts elicited only at early night) might depend on the increased levels of Tnfr1 expression. We also confirmed that LPS modulates clock gene expression in the SCN and PVN in WT but not in Tnfr1 KO mice.","palabras_clave":"CIRCADIAN RHYTHMS|IMMUNE|TNF-ALPHA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38344,"idioma_id":4,"titulo":"Building Memristive and Radiation Hardness TiO 2 based Junctions","resumen":"We studymicro-scale TiO2 junctions that are suitable to be used as resistive random-access memory nonvolatiledeviceswith radiation hardnessmemristive properties. The fabrication and structural and electrical characterizationof the junctions are presented. We obtained a retentivity of 105 s, an endurance of 104 cycles and reliableswitching with short electrical pulses (time-width below 10 ns). Additionally, the devices were exposed to25 MeV oxygen ions. Then, we performed electrical measurements comparing pristine and irradiated devicesin order to check the feasibility of using these junctions as memory elements with memristive and radiationhardness properties.","palabras_clave":"Memristive|Radiation hardness|Resistive switching|Non-volatile memories"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38345,"idioma_id":4,"titulo":"Dimers of Perhaloacetyl Cyanides: CClF2C(O)OC(CN)2CClF2 and CF3C(O)OC(CN) 2CF3 . Preparation, Properties and Spectroscopy","resumen":"The vapor of the new compound 1,1-dicyano-2-chloro-2,2-difluoroethyl chlorodifluoroacetate, CClF2C(O)OC(CN)2CClF2 and of the known 1,1-dicyano-2,2,2-trifluoroethyl trifluoroacetate, CF3C(O)OC(CN)2CF3, were investigated using vibrational spectroscopy tools. The existence of rotational isomerism was confirmed for CClF2C(O)OC(CN)2CClF2 when the matrix isolated compound was examined in combination with the computational results applying quantum chemical models. From the four conformers gauche-syn-gauche, gauche-syn-anti, syn-syn-anti, syn-syn-gauche (the used nomenclature is with respect to the (ClC?C(O)), ((O)C-OC), and (OC?CCl) torsion angles, respectively) predicted for CClF2C(O)OC(CN)2CClF2 the first two forms can be evidenced using Ar-matrix IR spectroscopy, with the first one being the most abundant at room temperature. On the other side, the results obtained for CF3C(O)OC(CN)2CF3 reveals the existence of only one syn-syn-anti form. CClF2C(O)OC(CN)2CClF2 melts at &#8722;40 °C and its vapor pressure was fitted by the equation ln p = &#8722;4732.6 (1\/T) + 10.75 (p [Atm], T [K]) in the range &#8722;20 to 20 °C. Its extrapolated boiling point is 167 °C. The first ionization potentials occur for CClF2C(O)OC(CN)2CClF2 and CF3C(O)OC(CN)2CF3 at 12.13 and 12.43 eV, respectively, and were attributed to the ejection of electrons formally located at the carbonylic oxygen lone-pair electrons (nO). The proposed interpretation of the photoelectron spectrum is consistent with related molecules reported previously, and also with the prediction of Outer Valence Green?s Functions (OVGF).","palabras_clave":"Synthesis|Spectroscopic Properties|Quantum Chemical Calculations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38346,"idioma_id":4,"titulo":"Rheological and barrier properties of nanocomposites of HDPE and exfoliated Montmorillonite","resumen":"Polyethylene (PE) \/ clay nanocomposites were prepared by melt mixing using polyethylene grafted with maleic anhydride (PEg) as compatibilizer. Concentrations between 2 and 15 wt% of an organophilic montmorillonite (MMT) and concentration ratios of 1:1, 2:1 and 3:1 of PEg\/MMT were employed. The materials were characterized using X-ray diffraction, scanning electron microscopy (SEM) and thermogravimetry. The SEM images show that the presence of PEg gives place to a large degree of exfoliation at all clay concentrations. For 5 wt% MMT, the best degree of exfoliation is obtained for a 2:1 ratio of PEg\/MMT. This ratio also gives place to the largest increase of the elastic modulus, mainly at low frequencies, with respect to that of the corresponding matrix. As the clay concentration increases, for a 2:1 ratio of PEg\/MMT, the dynamic moduli increases showing pseudo solid-like behavior at clay concentrations higher than 8 wt%. Moreover, the nanocomposites show rheological properties that are affected by annealing at 200°C signaling further exfoliation or improved platelet and tactoid distributions. The oxygen permeability of PE gradually decreases with clay concentration, reaching a maximum reduction of ~30% for 15 wt% MMT.","palabras_clave":"NANOCOMPOSITES|POLYETHYLENE|RHEOLOGICAL PROPERTIES|PERMEABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38347,"idioma_id":4,"titulo":"Molecular, Rheological and Thermal Study of Long-Chain Branched Polypropylene Obtained by Esterification of Anhydride Grafted Polypropylene","resumen":"Long-chain branched polypropylene was prepared using reaction in the molten state in the presence of glycerol and a linear  polypropylene functionalized with maleic anhydride (PPg). The concentration of glycerol in the melt was varied in the range from 0.1  to 5 wt % to obtain different levels of branching. FTIR spectroscopy results indicate that the OH groups of glycerol react with the anhydrides on the PPg chains giving place to ester groups. The presence of longchain branches in the molecular structure of PPg was confirmed using multiple detection size-exclusion chromatography and rheology. These techniques demonstrate that the level of branching increases with glycerol concentration and that the modification of PPg produces materials with a bimodal distribution of polymer species. Moreover, some of the highly modified materials display gel-like behavior. The materials also display thermo-rheological complexity  and enhanced activation energy at low frequencies. The crystallization study shows that both the anhydride groups in PPg and the LCBs  have opposite nucleating effects. PPg presents the largest activation energy of crystallization and its value decreases with the concentration of glycerol for a given level of crystallization.","palabras_clave":"POLYOLEFINS|STRUCTURE PROPERTY RELATIONS|CROSSLINKING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38348,"idioma_id":4,"titulo":"FRICTION AND WEAR BEHAVIOR OF IRRADIATED POLYETHYLENE SLIDING AGAINST ROUGH STEEL SURFACE","resumen":"The aim of this study was to evaluate the tribological behavior of polyethylene crosslinked by gamma radiation sliding against steel surface. Two high density polyethylenes were irradiated under vacuum at room temperature to total doses in the range from 2 to 20 Mrad. After irradiation, the materials were annealed at 423 K for 5 minutes and then cooled slowly to room temperature. The same treatment was applied to the non-irradiated polymer.  The wear behavior was determined at controlled ambient temperature of 298 K and 333 K using a homemade tribometer. Sheet-shaped test pieces were placed in contact with a surface of a steel disc by applying different normal loads between 2.5 and 15 N. The tests were performed under dry conditions using a disc rotational speed of 375 rpm for 30 minutes. The wear rate was obtained as the mass loss of the sample divided by the sliding distance and the friction coefficient was determined by measuring the force of friction.   The results indicate that the wear rate increases with load in the case of non-irradiated polyethylene and low-dose irradiated polymers, while the wear rate reaches a maximum value with the load in the case of the irradiated samples with high dose. The samples irradiated with a dose of 10 Mrad showed the lowest wear.   The coefficient of friction increases slightly with the load in all the cases. Most irradiated polymers have higher coefficient of friction than the non-irradiated material when compared to a particular load, although it was not possible to determine a relationship between the coefficient of friction with the dose in irradiated materials.","palabras_clave":"ABRASIVE WEAR|CROSS-LINKED|POLYETHYLENE|FRICTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38349,"idioma_id":5,"titulo":"Presencia del pesticida carbofuran (carbamato) en muestras de cebo y contenido gástrico de caninos de la Ciudad de Urdinarrain, Entre Ríos","resumen":"Numerosas sustancias de origen natural o sintético pueden comportarse como tóxicas cuando ingresan al organismo. Caninos y felinos se hallan expuestos a sustancias que se encuentran con frecuencia en su entorno (productos de limpieza, pesticidas, rodenticidas)Los pesticidas son ampliamente utilizados en la producción agrícola como método de control de plagas. Entre ellos, los organofosforados y los carbamatos son utilizados a nivel mundial debido a su eficacia y relativo bajo costo. El carbofuran es un carbamato de amplio espectro cuyo uso se encuentra prohibido en Europa y Estados Unidos, pero que sin embargo todavía se utiliza en Latinoamérica. En el siguiente trabajo se presentan los hallazgos obtenidos a partir del análisis por cromatografía gaseosa y espectrometría de masa de dos muestras de cebo contaminadas con carbofuran provenientes de Urdinarrain, Entre Ríos. Las mismas provocaron la muerte de dos caninos pese a los esfuerzos realizados por el veterinario actuante. Se deja constancia sobre el uso malicioso de esta sustancia cuya toxicidad reporta gran riesgo no solo para los animales sino también para el ser humano.","palabras_clave":"Canino|Intoxicación|Carbofuran|Cebo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38350,"idioma_id":4,"titulo":"The Trypanosoma cruzi Satellite DNA OligoC-TesT and Trypanosoma cruzi Kinetoplast DNA OligoC-TesT for Diagnosis of Chagas Disease: A Multi-cohort  Comparative Evaluation Study","resumen":"Background: The Trypanosoma cruzi satellite DNA (satDNA) OligoC-TesT is a standardised PCR format for diagnosis of Chagas disease. The sensitivity of the test is lower for discrete typing unit (DTU) TcI than for TcII-VI and the test has not been evaluated in chronic Chagas disease patients.  Methodology\/Principal Findings: We developed a new prototype of the OligoC-TesT based on kinetoplast DNA (kDNA)detection. We evaluated the satDNA and kDNA OligoC-TesTs in a multi-cohort study with 187 chronic Chagas patients and 88 healthy endemic controls recruited in Argentina, Chile and Spain and 26 diseased non-endemic controls from D.R. Congo  and Sudan. All specimens were tested in duplicate. The overall specificity in the controls was 99.1% (95% CI 95.2%?99.8%)  for the satDNA OligoC-TesT and 97.4% (95% CI 92.6%?99.1%) for the kDNA OligoC-TesT. The overall sensitivity in the patients was 67.9% (95% CI 60.9%?74.2%) for the satDNA OligoC-TesT and 79.1% (95% CI 72.8%?84.4%) for the kDNA OligoC-Test.  Conclusions\/Significance: Specificities of the two T. cruzi OligoC-TesT prototypes are high on non-endemic and endemic controls. Sensitivities are moderate but significantly (p = 0.0004) higher for the kDNA OligoC-TesT compared to the satDNA OligoC-TesT.","palabras_clave":"TRYPANOSOMA CRUZI|DIAGNOSTIC|CHAGAS DISEASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38351,"idioma_id":4,"titulo":"The pion distribution amplitude and the pion-photon transition form factor in a nonlocal chiral quark model","resumen":"We study the pion Distribution Amplitude (piDA) in the context of a nonlocal chiral quark model. The corresponding Lagrangian reproduces the phenomenological values of the pion mass and decay constant, as well as the momentum dependence of the quark propagator obtained in latticecalculations. It is found that the obtained piDA has two symmetric maxima, which arise from the new contributions generated by the nonlocal character of the interactions. This piDA is applied to leading order and next-to-leading order calculations of the pion-photon transition form factor. Implications of the results are discussed.","palabras_clave":"Relativistic quark models|Quantum chromodynamics|Distribution amplitudes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38352,"idioma_id":4,"titulo":"Galectins: major signaling modulators inside and outside the cell","resumen":"Galectins control cell behavior by acting on different signaling pathways. Most of the biological  activities ascribed to these molecules rely upon recognition of extracellular glycoconjugates and establishment  of multivalente interactions, which trigger adaptive biological responses. However, galectins are also detected  within the cell in different compartments, where their regulatory functions still remain poorly understood. A  deeper understanding of the entire galectin signalosome and its impact in cell behavior is therefore essential in  order to delineate new strategies to specifically manipulate both galectin expression and function. This review  summarizes our current knowledge of the signaling pathways activated by galectins, their glycan dependence  and the cellular compartment where they become activated and are biologically relevant.","palabras_clave":"APOPTOSIS|CELL ADHERENCE|GALECTINS|IMMUNE REGULATION|ONCOGENESIS|SIGNALING PATHWAYS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38353,"idioma_id":4,"titulo":"Structure, Management and Productivity  of Hedgerow Olive Orchards: A Review.","resumen":"Olive was introduced into cultivation more than 3000 years ago, but only during the last two decades has cultivation shifted from low density to dense hedgerow orchards. This development responds to the need for mechanization to reduce production costs and achieve more timely management interventions. There is, however, little scientific or commercial knowledge available to support this new planting system in olive and to contribute to its development. This review focuses on what is known and what knowledge is required for design and management of hedgerow orchards for continuing productivity and economic viability. The review adopts a targeted approach based on consideration of the impact of orchard structure on microenvironment and production processes and oil quality. Particular emphasis is given to how orchard design and structure affect irradiance interception and how that determines productivity. The review also deals with establishment of orchards (cultivar selection, planting patterns,pruning for row formation) and maintenance of hedgerows for continuing productivity (irrigation, fertilization, pruning to maintain structure and productivity, control of pests and diseases, and regeneration of failed hedgerows). An important underlying consideration is the strong interaction between design anddimensions of both hedgerows and harvesting machines with examples taken from the two common, high density (HD) and super-high density (SHD) orchard designs. The search for new machine designs continues simultaneously with that for cultivars, orchard layouts, and pruning systems better suited to this new production system. Currently, only three cultivars (?Arbequina?, ?Arbosana, ?Koroneiki?) dominate SHD orchards. Over-row harvesters must match hedgerow dimensions while tree structure and fruiting behavior must suit the harvester. Context is provided by identifying reasons for major differences from traditional olive culture and attitudes from which most existing information on tree response and successful management practice has been accumulated. To account for these differences, terminology is proposed to define hedgerow structure that is required for effective management of oil production, oil quality, sanitary conditions, and profitability under various conditions. The review continues with discussions of requirements and current performance of mechanical harvesters and a comparative lifecycle economic analysis of alternative HD and SHD systems. The latter demonstrates the complexity of analysis and its importance to the choice of orchard design at the outset of each new project. The review concludes with recommendations for basic and applied research to determine optimal hedgerow structures and management for individual situations, development of new cultivars, and maintenance of hedgerow structure for continuing productivity.","palabras_clave":"CULTIVAR|HARVESTERS|MICROCLIMATE|OLEA EUROPAEA L |ORCHARD DESIGN|ORCHARD ESTABLISHMENT |ORCHARD MAINTENANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38354,"idioma_id":4,"titulo":"Contrasting patterns of fatty acid composition and oil accumulation during fruit growth in several olive varieties and locations in a non-Mediterranean region","resumen":"Olive growing has expanded considerably in the last few decades outside of the Mediterranean Basin to non-traditional regions in the Southern Hemisphere. When growing olive genotypes (i.e., varieties) outside of their area of origin, the importance of environmental factors such as temperature and genotype×environment interactions in determining olive oil production and oil quality has been suggested. In several Mediterranean varieties and one South American variety, we assessed the dynamics of fruitgrowth and oil accumulation along with the evolution of fatty acid composition at multiple locations over two growing seasons. Oleic acid content (%), the principal fatty acid present in olive oil, showed four contrasting patterns during fruit growth when modeled against thermal time from flowering using linear and bilinear regressions: (1) a sharp linear decrease for the varieties ?Arauco? and ?Arbequina?; (2) a plateau followed by a late linear decrease of moderate slope for ?Barnea? and ?Manzanilla Fina?; (3) a slow linear decrease for ?Frantoio?; and (4) no decrease in ?Coratina?. Linoleic acid (%) showed linearincreases in ?Arauco? and ?Arbequina? that appear to be inversely related to the decreases in oleic acid, while bilinear patterns were found for many other varieties. Both the rates of fruit growth and of oil accumulation were more important in determining maximum fruit dry weight and oil concentration (%), respectively, than duration when expressed on a thermal time basis. Temperature during oil synthesis was negatively related to final oil concentration. Experiments under controlled conditions would greatly contribute to our understanding of how fruit growth as well as oil quantity and quality are influenced byenvironmental factors.","palabras_clave":"OLIVE|FATTY ACID|TEMPERATURE|FRUIT GROWTH|OIL CONCENTRATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38355,"idioma_id":4,"titulo":"Synthesis Of Silanized Maghemite Nanoparticles Onto Reduced Graphene Sheets Composites","resumen":"Novel gamma-Fe2O3@APTES@rGO composites are successfully synthesized by using graphene oxide and silanized maghemite nanoparticles. Graphene oxide and maghemite were obtained by Hummers and Massart methods, respectively. The silanization process was done to functionalize maghemite surface with a controllable quantity of amino groups. Then, by adding aqueous graphene oxide suspension, the bonding between graphene oxide and silanized maghemite nanoparticles was done in refluxing conditions. Afterwards, chemical reduced graphene oxide reaction was realized by addition of hydrazine solution. The characterization of gamma-Fe2O3@APTES@rGO composites was studied by X-ray Diffraction, Fourier Transformed Infrared Spectroscopy, thermogravimetric analysis and scanning electron microscopy.","palabras_clave":"Maghemite|APTES|Graphene|surface density"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38356,"idioma_id":4,"titulo":"The crystal structure of sarmientite, Fe3+2(AsO4)(SO4)(OH)·5H2O, solved ab initio from laboratory powder diffraction data","resumen":"The crystal structure of sarmientite, Formula (AsO4)(SO4)(OH)·5H2O, from the type locality (Santa Elena mine, San Juan Province, Argentina), was solved and refined from in-house powder diffraction data (CuK&#945;1,2 radiation). It is monoclinic, space group P21\/n, with unit-cell dimensions a = 6.5298(1), b = 18.5228(4), c = 9.6344(3) Å, b = 97.444(2)°, V = 1155.5(5) Å3, and Z = 4. The structure model was derived from cluster-based Patterson-function direct methods and refined by means of the Rietveld method to Rwp = 0.0733 (&#967;2 = 2.20). The structure consists of pairs of octahedral-tetrahedral (Fe?As) chains at (y,z) = (0,0) and (½,½), running along a. There are two symmetry-independent octahedral Fe sites. The Fe1 octahedra share two corners with the neighbouring arsenate groups. Both individual chains are related by a symmetry centre and joined by two symmetry-related Fe2 octahedra. Each Fe2 octahedron shares three corners with double-chain polyhedra (O3, O4 with arsenate groups; the O8 hydroxyl group with the Fe1 octahedron) and one corner (O11) with the monodentate sulfate group. The coordination of the Fe2 octahedron is completed by two H2O molecules (O9 and O10). There is also a complex network of H bonds that connects polyhedra within and among chains. Raman and infrared spectra show that (SO4)2&#8722; tetrahedra are strongly distorted.","palabras_clave":"arsenic|rietveld refinement|sulfate|octahedral-tetrahedral chains"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38358,"idioma_id":4,"titulo":"Mesoporous titania thin films as efficient enzyme carriers for paraoxon determination\/detoxification: effects of enzyme binding and pore hierarchy in biocatalyst activity and reusability","resumen":"The aims of this work were to efficiently immobilize organophosphate degrading enzyme, His6-OPH, on hierarchical mesoporoustitania thin films and further, to use this biocatalyst films as efficient tools in the detection\/detoxofication of pesticides, paraoxon in our case. His6-OPH was immobilized on mesoporous thin films with uniform (9nm) and bimodal (13-38nm) pore size distribution, through covalent attachment and physical adsorption. The biocatalyst films show good activity, and enhanced stability with respect to the free enzyme at extreme conditions of pH and temperature, especially around neutral pH and room temperature. In addition, they can be easily separated from the reaction media and reused multiple times without significant loss in activity.","palabras_clave":"hierarchical mesoporous thin films|TiO2|adsorption\/covalent attachment|organophosphate hydrolysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38359,"idioma_id":4,"titulo":"Inverse Problem of Capillary Filling","resumen":"The inverse problem of capillary filling, as defined in this work, consists in determining the capillaryradius profile from experimental data of the meniscus position l as a function of time t. This problem is central in diverse applications, such as the characterization of nanopore arrays or the design of&nbsp; passive transport in microfluidics; it is mathematically ill posed and has multiple solutions; i.e., capillaries with different geometries may produce the same imbibition kinematics. Here a suitable approach is proposed to solve this problem, which is based on measuring the imbibition kinematics in both tube directions. Capillary filling experiments to validate the calculation were made in a wide range of length scales: glass capillaries with a radius of around 150 &#956;m and anodized alumina membranes with a pores radius of around 30 nm were used. The proposed method was successful in identifying the radius profile in both systems. Fundamental aspects also emerge in this study, notably the fact that the l(t) &#8733; t^0.5 kinematics (Lucas-Washburn relation) is not exclusive of uniform cross-sectional capillaries.","palabras_clave":"Capillary Filling|Optofluidic|Inverse Problem"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38360,"idioma_id":4,"titulo":"Glucitol Dehydrogenase from Peach (Prunus persica) Fruits is Regulated by Thioredoxin h","resumen":"Glucitol (Gol) is a major photosynthetic product in plants from the Rosaceae family. Herein we report the molecular cloning, heterologous expression and characterization of Goldehydrogenase (GolDHase, EC 1.1.1.14) from peach (Prunus persica) fruits. The recombinant enzyme showed kinetic parameters similar to those reported for orthologous enzymes purified from apple and pear fruits. The activity of recombinant GolDHase was strongly inhibited by Cu2+ and Hg2+, suggesting that it might have cysteine residues critical for functionality. Oxidizing compounds (such as diamide, hydrogen peroxide and oxidized glutathione) inactivated the enzyme, whereas its activity was restored after incubation with reduced glutathione and thioredoxin from Escherichia coli. Recombinant thioredoxin h from peach fruits also recovered the activity of oxidized GolDHase. Our results suggest that peach fruit GolDHase could be redox regulated in vivo and this would be of relevance to determine carbon assimilation and partitioning in plants accumulating sugar alcohols.","palabras_clave":"Glucitol dehydrogenase|Glucitol metabolism|Prunus persica|Thioredoxin redox regulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38361,"idioma_id":5,"titulo":"Evaluación de la calidad de servicio universitario desde la percepción de estudiantes y docentes: caso de estudio","resumen":"Se plantea la evaluación de la calidad de los servicios universitarios de una universidad privada de Argentina desde la percepción de estudiantes y docentes. Para ello se adecuó la escala de Capelleras y Veciana (2004), basados en el modelo SERVQUAL, y se incorporaron ítems que atienden a otros aspectos del servicio universitario tales como los que proponen Rubio Gómez, Aguilar Feijoo, Massa Sánchez, Maldonado y Ramírez Asanza (2005), referentes a la adecuación de los programas, a la evaluación del aprendizaje y a la efectividad de los procesos administrativos. La escala de 42 variables relativas a las percepciones de la calidad de los servicios, y a las condiciones de la institución para ofrecerlos, se aplicó a una muestra de 454 estudiantes y 64 docentes. Los resultados mostraron consistencia interna y el Análisis de Factores identificó ocho dimensiones que permiten proponer mejoras en atención a lo que exhiben los resultados obtenidos.","palabras_clave":"Calidad educativa|Percepción.|Servicio, Medición"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38362,"idioma_id":4,"titulo":"Epithelial cadherin is present in bovine oviduct epithelial cells and gametes, and is involved in fertilization-related events","resumen":"Fertilization is a calcium-dependent process that involves sequential cell-cell adhesion events of spermatozoa with oviduct epithelial cells (OECs) and with cumulus-oocyte complexes (COCs). Epithelial cadherin (E-cadherin) participates in calcium-dependent somatic cell adhesion; the adaptor protein &#946;-catenin binds to the E-cadherin cytoplasmic domain and links the adhesion protein to the cytoskeleton. The study was conducted to immunodetect E-cadherin and &#946;-catenin in bovine gametes and oviduct (tissue sections and OEC monolayers), and to assess E-cadherin participation in fertilization-related events. Epithelial cadherin was found in spermatozoa, oocytes, cumulus cells, and OEC. In acrosome-intact noncapacitated spermatozoa, E-cadherin was mainly localized in the apical ridge and acrosomal cap (E1-pattern; 84 ± 9%; mean ± standard deviation of the mean). After sperm treatment with heparin to promote capacitation, the percentage of cells with E1-pattern (56 ± 12%) significantly decreased; concomitantly, the percentage of spermatozoa depicting an E-cadherin staining pattern similar to E1-pattern but showing a signal loss in the acrosomal cap (E2-pattern: 40 ± 11%) increased. After l-&#945;-lysophosphatidylcholine-induced acrosome reaction, E-cadherin signal was mainly localized in the inner acrosomal membrane (E3-pattern: 67 ± 22%). In IVM COC, E-cadherin was immunodetected in the plasma membrane of cumulus cells and oocytes, but was absent in the polar body. The 120 KDa mature protein form was found in protein extracts from spermatozoa, oocytes, cumulus cells, and OEC. &#946;-Catenin distribution followed E-cadherin´s in all cells evaluated. Epithelial cadherin participation in cell-cell interaction was evaluated using specific blocking monoclonal antibody DECMA-1. Sperm incubation with DECMA-1 impaired sperm-OEC binding (the number of sperm bound to OEC: DECMA-1 = 6.7 ± 6.1 vs. control = 29.6 ± 20.1; P < 0.001), fertilization with COC (% fertilized COC: DECMA-1 = 68.8 ± 10.4 vs. control = 90.7 ± 3.1; P < 0.05) or denuded oocytes (% fertilized oocytes: DECMA-1 = 57.0 ± 15.2 vs. control = 89.2 ± 9.8; P < 0.05) and binding to the oolemma (the number of sperm bound to oolemma: DECMA-1 = 2.2 ± 1.1 vs. control = 11.1 ± 4.8; P < 0.05). This study describes, for the first time, the presence of E-cadherin in bovine spermatozoa, COC, and OEC, and shows evidence of its participation in sperm interaction with the oviduct and the oocyte during fertilization.","palabras_clave":"fertilization|bovine|cadherin|gametes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38363,"idioma_id":4,"titulo":"The use of shells as tools by hunters-gatherers in the Beagle Channel (Tierra del Fuego, South America): an ethnoarchaeological experiment","resumen":"This paper presents the results of the analysis of lipid residues extracted from two Aulacomya ater shells and a single Mytilus edulis shell found in the hunter-fisher-gatherer site of Lanashuaia II (Beagle Channel, Tierra del Fuego, Argentina). According to existing ethnographic information, the shells could have been used as receptacles (like spoons) by the Yamana people that inhabited the region. Higher concentrations of lipid residues were recovered from both Aulacomya ater shells than from the sedimentary control sample analyzed. This is consistent with existing accounts that these types of shells were used as containers to cook or melt fat rich foods. The composition of lipids extracted from archaeological shell was significantly different from the degraded reference cooking residues prepared from modern Aulacomya ater shells.","palabras_clave":"LIPID RESIDUES|SHELL MIDDEN|TIERRA DEL FUEGO|HUNTER-GATHERERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38364,"idioma_id":4,"titulo":"Isolation of lactoferrin from whey by dye-affinity chromatography with Yellow HE-4R attached to chitosan mini-spheres","resumen":"Novel integrated chromatographic methods need to be developed for specific, low-cost protein purificationfrom raw materials. Here, a process for bovine lactoferrin (Lf) isolation from sweet whey wasdeveloped using cross-linked chitosan mini-spheres with immobilised Yellow HE-4R dye as a low-costligand. The maximum adsorption capacity was between 51.14 and 58.28 mg Lf g1 matrix. In addition,the mini-spheres adsorbed around 95% of the Lf present in the sweet whey and eluted more than 80% ofthe adsorbed Lf. A yield of 77% with purity greater than 90% was achieved in only one purification step.The purification process was efficient for three consecutive cycles without regeneration steps.","palabras_clave":"BOVINE LACTOFERRIN|PURIFICATION|WHEY|DYE-AFFINITY CHROMATOGRAPHY|CHITOSAN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38365,"idioma_id":4,"titulo":"Increased Na+ \/Ca2+ Exchanger Expression\/Activity Constitutes a Point of Inflection in the Progression to Heart Failure of Hypertensive Rats","resumen":"Spontaneously hypertensive rat (SHR) constitutes a genetic model widely used to study the  natural evolution of hypertensive heart disease. Ca2+-handling alterations are known to occur in  SHR. However, the putative modifications of Ca2+-handling proteins during the progression to  heart failure (HF) are not well established. Moreover, the role of apoptosis in SHR is  controversial. We investigated intracellular Ca2+, Ca2+-handling proteins and apoptosis in SHR  vs. control Wistar rats (W) from 3 to 15 months (mo). Changes associated with the transition to  HF (i.e. lung edema and decrease in midwall fractional shortening), occurred at 15 mo in 38% of  SHR (SHRF). In SHRF, twitch and caffeine-induced Ca2+ transients, significantly decreased  relative to 6\/9 mo and 15 mo without HF signs. This decrease occurred in association with a  decrease in the time constant of caffeine-Ca2+ transient decay and an increase in Na+\/Ca2+  exchanger (NCX) abundance (p&lt;0.05) with no changes in SERCA2a expression\/activity. An  increased Ca2+-calmodulin-kinase II activity, associated with an enhancement of apoptosis  (TUNEL and Bax\/Bcl2) was observed in SHR relative to W at 3 to 15 mo. Conclusions: 1.  Apoptosis is an early and persistent event that may contribute to hypertrophic remodeling but  would not participate in the contractile impairment of SHRF. 2. The increase in NCX  expression\/activity, associated with an increase in Ca2+ efflux from the cell, constitutes the first  significant alteration of Ca2+-handling proteins in the evolution to HF. 3. No changes in  SERCA2a expression\/activity are observed when HF signs become evident","palabras_clave":"CALCIUM HANDLING|HYPERTENSIVE RATS|NA\/CA|HEART FAILURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38366,"idioma_id":4,"titulo":"A Comparative Study of the Biological Activity of Skin and Granular Gland Secretions of Leptodactylus latrans and Hypsiboas pulchellus from Argentina","resumen":"Abstract: the potential of the skin of anuran amphibians as a new source of bioactive peptides was investigated . For this purpose, the study collected data in the mid-eastern region of Argentina. Two anuran amphibian species were studied which belong to the Hylidae and Leptodactylidae families, Leptodatylus latrans (Ll) and Hypsiboas pulchellus (Hp). Two methods for the extraction of bioactive components were compared in their effectiveness: solvent extraction (SE) and transcutaneous amphibian stimulation (TAS). Two different approaches were used to study the extracts: i) the direct analysis of the complete samples by MALDI-TOF-MS, and ii) the characterization of bioactive fractions obtained by HPLC and analyzed by MS. The results show that not only the composition of the samples obtained by SE and TAS is different but also their antimicrobial activity. In this sense, only the extracts obtained from Ll and Hp by SE inhibited the growth of Mycobacterium tuberculosis H37Rv. The inhibitory activity of the extracts against the butyrylcholinesterase enzyme (BChE) was also investigated. Samples of Ll showed low percentages of inhibition whereas in Hp samples, the inhibition was moderate (40 -44%). The results suggest that the inhibitory activity of Hp is related to the presence of low molecular weight compounds.","palabras_clave":"anfibios|actividad antimicrobiana|inhibición de la butiril colinesterasa|péptidos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38367,"idioma_id":5,"titulo":"Las turberas de Tierra del Fuego y su importancia en el estudio del cambio climático","resumen":"Los  ecosistemas con capacidad para acumular y almacenar materia orgánica muerta derivada de plantas adaptadas a vivir en condiciones de saturación de agua permanentes, reducido contenido de oxigeno y escasa disponibilidad de nutrientes se denominan turbales. Turba es el nombre dado a la materia orgánica muerta en tales condiciones.   Una turbera es toda área donde la turba está siendo producida y acumulada progresivamente, incrementando el espesor del depósito orgánico.  La saturación por agua conduce a bajas temperaturas y bajo contenido de oxigeno, estas condiciones inhiben la actividad de microorganismos (hongos y bacterias) que normalmente producen la descomposición de la materia vegetal muerta. De esta manera, la materia vegetal es descompuesta en una tasa menor a la que es producida, lo cual permite la acumulación de turba.  Además de especies vegetales, en la superficie de los turbales conviven un gran número de organismos tales como insectos, hongos y algas microscópicas.   La formación de una turbera se ve favorecida por la presencia de cubetas o depresiones cerradas en las que se forman pequeños lagos y lagunas. Este tipo de paisajes está asociado principalmente a zonas que han estado sometidas a la acción erosiva de glaciares. El trabajo erosivo del glaciar sobre la roca o sedimento en el cual fluye genera este tipo de depresiones o cubetas. Posteriormente, cuando el glaciar retrocede y abandona estas depresiones, se produce la inundación de las pequeñas cubetas, ya sea por escurrimiento de agua de superficie desde las laderas adyacentes o por la presencia de napas freáticas altas, dando origen a lagos y lagunas. Luego, una disminución en la profundidad de estos cuerpos de agua dulce, junto al crecimiento de vegetación asociada a ambientes con abundante disposición de agua, produce un gradual avance y colonización por parte de la vegetación sobre el lago o laguna generándose así las turberas. Cambios en las condiciones de drenaje en una turbera pueden producir un cambio en el tipo de vegetación que la forma, generándose de esta manera más de un tipo de turba con diferentes características en una misma turbera.   Las turberas también pueden formarse en adyacencias a arroyos y ríos, en las planicies de inundación y meandros abandonados. En las primeras, de relieve plano, las condiciones de drenaje ineficientes favorecen el anegamiento de grandes áreas permitiendo el crecimiento de vegetación típica de turberas; en los meandros abandonados, el agua residual estancada se coloniza por especies acuáticas y se inicia el proceso de colonización y sucesión vegetal.","palabras_clave":"TURBERAS |TIERRA DEL FUEGO|CAMBIO CLIMATICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38368,"idioma_id":4,"titulo":"Non isothermal kinetic study of the aluminium titanate formation in alumina-titania mixtures","resumen":"Aluminum titanate (Al2TiO5) is a high refractoriness material with excellent thermal shock resistance. Hence it is suitable for several applications at elevated temperatures where insulation and thermal shock resistance are required. Such as components of internal combustion engines, exhaust port liners, metallurgy, and thermal barriers. The thermal instability of Al2TiO5 at high temperature is another characteristic of this material that has been studied and controlled by the incorporation of several additives. The Al2TiO5 formation from pure oxides presents an endothermic peak in the differential thermal analysis (DTA). The thermodynamic temperature is 1280 ºC. But experimentally, as in every other DTA experiment, these peaks strongly depend on the heating rate: this fact has been extensively employed for the kinetic study of transformation processes and the mechanism determination of chemical reactions. Both activation energies (Ea) and nucleation rates can be obtained from these experiments. The present work reports the formation Ea of Al2TiO5 prepared from pure oxides at air atmosphere by the Kissinger DTA based methods. Previously the particle size distribution of the starting powders together with X-ray diffraction analysis of the starting powders and the resulting materials was carried out. The properties of the Al2TiO5 formation were grouped into two groups corresponding to the low and high heating rates, below and over 5 K\/min. Ea values were obtained after the Avrami (n) constant evidenced that the crystallization mechanism is strongly related to the heating rate, even in the wide range studied which includes the technological ones(0.5-40 K\/min). 2TiO5) is a high refractoriness material with excellent thermal shock resistance. Hence it is suitable for several applications at elevated temperatures where insulation and thermal shock resistance are required. Such as components of internal combustion engines, exhaust port liners, metallurgy, and thermal barriers. The thermal instability of Al2TiO5 at high temperature is another characteristic of this material that has been studied and controlled by the incorporation of several additives. The Al2TiO5 formation from pure oxides presents an endothermic peak in the differential thermal analysis (DTA). The thermodynamic temperature is 1280 ºC. But experimentally, as in every other DTA experiment, these peaks strongly depend on the heating rate: this fact has been extensively employed for the kinetic study of transformation processes and the mechanism determination of chemical reactions. Both activation energies (Ea) and nucleation rates can be obtained from these experiments. The present work reports the formation Ea of Al2TiO5 prepared from pure oxides at air atmosphere by the Kissinger DTA based methods. Previously the particle size distribution of the starting powders together with X-ray diffraction analysis of the starting powders and the resulting materials was carried out. The properties of the Al2TiO5 formation were grouped into two groups corresponding to the low and high heating rates, below and over 5 K\/min. Ea values were obtained after the Avrami (n) constant evidenced that the crystallization mechanism is strongly related to the heating rate, even in the wide range studied which includes the technological ones(0.5-40 K\/min). ","palabras_clave":"CERAMICOS|TITANATE|SINTERING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38369,"idioma_id":4,"titulo":"Surveillance  of  group  A  Rotavirus  in  Buenos  Aires  2008?2011,  long lasting  circulation  of  G2P[4]  strains  possibly  linked  to  massive monovalent  vaccination  in  the  region.","resumen":"Background  Group A rotaviruses (RVA) are the most frequent single etiological agents of severe diarrhea in infants. Since 2006 RVA vaccines have been introduced in national schedules of middle and high income countries with substantial declines in rotavirus associated disease burden. However, surveillance must be maintained to, eventually, detect emerging types or variants selected by the new pressure imposed by vaccination.  Objectives  To analyze the molecular epidemiology of group A rotavirus after vaccine introduction in the region in the context of data from more than 15 years of continuous surveillance in Buenos Aires.  Study design  RVA positive diarrhea samples collected in Buenos Aires from 2008 to 2011 were genotyped by RT-PCR. Selected samples were sequenced to gain insight on evolution of common and globally emerging human RVA strains.  Results  Lineage III G12P[8] strain emerged in 2008 in Buenos Aires and shared co-dominancy with G3 strains during 2009. An atypical long lasting circulation of G2P[4] strains since 2004 reached rates around 80% in 2011 in Buenos Aires. Sequencing of the VP7 and VP4 genes of representative G2P[4] isolates suggests Brazil as the origin of the 2010?2011 strains.  Conclusions  Globally emergent G12 lineage III strains could be established as dominant strains in a very populated area in two years since emergence. In this work it was also shown that the persistence of G2P[4] strains during 8 years could be related to massive immunization with the monovalent vaccine in the region.","palabras_clave":"rotavirus|diarrhea|vaccines|phylogeny"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38370,"idioma_id":4,"titulo":"Targeting a Cross-Reactive Gly m 5 Soy Peptide as Responsible for Hypersensitivity Reactions in a Milk Allergy Mouse Model","resumen":"    BACKGROUND:     Cross-reactivity between soybean  allergens and bovine caseins has been previously reported. In this study we  aimed to map epitopes of the major soybean allergen Gly m 5 that are  co-recognized by casein specific antibodies, and to identify a peptide  responsible for the cross-reactivity.    METHODS:     Cow´s milk protein (CMP)-specific  antibodies were used in different immunoassays (immunoblotting, ELISA, ELISA  inhibition test) to evaluate the in vitro recognition of soybean proteins (SP).  Recombinant Gly m 5 (&#945;), a truncated fragment containing the C-terminal domain  (&#945;-T) and peptides of &#945;-T were obtained and epitope mapping was performed with  an overlapping peptide assay. Bioinformatics tools were used for epitope  prediction by sequence alignment, and for modelling the cross-recognized soy  proteins and peptides. The binding of SP to a monoclonal antibody was studied  by surface Plasmon resonance (SPR). Finally, the in vivo cross-recognition of  SP was assessed in a mouse model of milk allergy.    RESULTS:     Both &#945; and &#945;-T reacted with the  different CMP-specific antibodies. &#945;-T contains IgG and IgE epitopes in several  peptides, particularly in the peptide named PA. Besides, we found similar  values of association and dissociation constants between the &#945;-casein specific  mAb and the different milk and soy components. The food allergy mouse model  showed that SP and PA contain the cross-reactive B and T epitopes, which  triggered hypersensitivity reactions and a Th2-mediated response on  CMP-sensitized mice.    CONCLUSIONS:     Gly m 5 is a cross-reactive soy  allergen and the &#945;-T portion of the molecule contains IgG and IgE  immunodominant epitopes, confined to PA, a region with enough conformation to  be bound by antibodies. These findings contribute to explain the intolerance to  SP observed in IgE-mediated CMA patients, primarily not sensitised to SP, as  well as it sets the basis to propose a mucosal immunotherapy for milk allergy  using this soy peptide  ","palabras_clave":"milk allergy|soy allergen|IgE|soybean Gly m 5"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38371,"idioma_id":4,"titulo":"Tectonic evolution of the North Patagonian Andes from field and gravity data (39-40ºS).","resumen":"This paper analyzes the style, distribution, mechanics and timing of deformation of the Andean retroarc zone between 39 and 40S, in the North Patagonian Andes. Field recognition and interpretation of the  main structures, constrained by new gravity data allowed establishing a structural control for the main sedimentary successions that coexisted with Andean development. A balanced cross section is constructed,  where the westernmost segment is characterized by a thick-skinned structure associated with a deep decollment, over which Late Paleozoic rocks are uplifted on top of Cenozoic successions. To the east,  a central segment was formed by Late Miocene inversion of a late Oligocene backarc basin controlled by a shallower decollment. A new K\/Ar age of 29 Ma constrains the age of these synextensional deposits.  Gravity data show the rhomboedric geometry and depth of these depocenters affecting the basement in the western orogenic front area. Finally, an eastern sector is characterized by the inversion of Late Triassic  structures and development of primary faults over a deeper decollment, producing a west-vergent deformational belt. The restoration of the structural profile has yielded a total shortening of less than  10 km produced in more than one contractional stage. The complex structure described in this work results from the interaction of NW structures related to the typical Andean deformation, and ENE  structures related to the intraplate Huincul high. Finally, previous works had visualized in seismic tomographies an area of relatively low velocities in the orogenic front area, interpreting it as a mantlederived  magmatic-hydrothermal crustal reservoir. Computed elastic thicknesses performed in this work from gravity data show a good correlation between areas of low flexural rigidity and areas of low seismic velocities. These anomalies coincide at surface with Pliocene to Quaternary retroarc mafic  eruptions that could have a connection to slab tearing processes proposed for the last 5e2 Ma from seismic data.","palabras_clave":"North Patagonian Andes|Contractional stages|Extensional stages|Tectonic evolution"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38372,"idioma_id":4,"titulo":"Two approaches to the study of a controversial relationship: cutaneous photosensitivity and anti-Ro\/SS-A autoantibodies","resumen":"ABSTRACTBackground: Autoantibodies (Aabs) are the hallmark of numerous systemic autoimmune pathologies (SAPs), for instance anti-Ro\/SS-A Aabs are usually found in Systemic Lupus Erythematosus (SLE) and Sjogren?s Syndrome. Cutaneous photosensitivity (CP) is found in most forms and subsets of LE and consists of a skin rash as a result of unusual reaction to sunlight. There are many theories which relate specifically the presence of circulating anti-Ro\/SS-A Aabs with the CP phenomenon, though there are several studies which are in disagreement. Results: In this study we analyzed the relationship between CP and anti-Ro Aabs by means of two approaches. The first one included an in vitro model where we evaluated by flow cytometry the binding capacity of affinity-purified Aabs to autoantigens relocalized on apoptotic keratinocyte?s surface. We found that there was no relationship between the binding capacity of serum from 10 selected patients or their corresponding purified anti-Ro52 and anti-Ro60 Aabs, and the presence or absence of CP, neither with the SAPs. The in vivo model consisted of Hairless SKH:1 mice which were induced to produce anti-murine Ro52 and\/or Ro60 Aabs and were subsequently irradiated with UVB light. We evaluated the skin histology and also the epidermal production of TNF-&#945;. We found no differences between the groups in neither of the parameters evaluated. Conclusions: These results agree with some studies on the role of the Aabs in CP, considering anti-Ro Aabs not as the only responsible for the manifestation; and disagree with many other authors, who believe in the strong association between these two events.","palabras_clave":"Cutaneous Photosensitivity|Purified Anti-Ro\/SS-A Autoantibodies|SKH-1 Hairless Mice|UVB Irradiation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38373,"idioma_id":4,"titulo":"Mitochondrial Dysfunction and Tissue Alterations of Ultraviolet-Irradiated Skin in Five Different Mice Strains","resumen":"Abstract: Ultraviolet radiation (UVR) effects on skin have been extensively studied. Several mice strains have been used worldwide in photobiology and photoimmunology studies. Recently, we have developed a method based on flow cytometry in order to analyze mitochondrial dysfunction and superoxide (O2?-) production ex vivo in keratinocytes isolated from irradiated-mice. This method can be helpful to evaluate mitochondrial alterations in different mice models.In this work, we aimed to compare epidermal response to UVR in five mice strains, both pigmented and albino as well as hairy and hairless strains (SKH:1, Balb\/c, C57\/BL, DBA\/2N and Swiss). Keratinocytes mitochondrial alterations, epidermal hyperplasia and inflammatory mediators? production (epidermis and serum) were determined 72 hours after a 400 mJ\/cm2 UV dose.All strains showed epidermal hyperplasia and loss of mitochondrial polarization after irradiation, differing in the magnitude of the response. However, there were significant differences in the basal mitochondrial polarization between strains, showing that the metabolic state of keratinocytes may vary between them. Moreover, mitochondrial O2?- production was induced in SKH:1 and Balb\/c after irradiation, whereas in DBA\/2N, Swiss and C57\/BL it was at the same level or even lower than in the non-irradiated control. Finally, an increase in inflammatory mediators was only detected in the serum of C57\/BL and Swiss mice and in the epidermis of DBA\/2N and C57\/BL.Results show that each mice strain has particular characteristics related to cellular metabolism, which may lead to particular responses to UVR exposure. Therefore, the use of a particular mice strain in photobiology models should be carefully considered.","palabras_clave":"Mitochondrial function|Inflammation|UV irradiation|epidermis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38374,"idioma_id":4,"titulo":"Photochemotherapy using natural anthraquinones: rubiadin and Soranjidiol sensitize human cancer cell to die by apoptosis","resumen":"Over the past decade the science has studied synthetic photosensitizers used in photodynamic therapy (PDT) or photochemotherapy as anticancer candidates. In this context, compounds extracted from vegetable species present interesting potential in the cancer field. In our laboratory, we studied Heterophyllaea pustulata a phototoxic shrub that habit the northwest of Argentina. From this vegetal, by in vitro germination, we obtained Rubiadin and Soranjidiol, two anthraquinones that exhibited significant photocytotoxicity on human cancer cells. In addition, the fraction obtained from callus cultures allowed us to get a satisfactory content of these compounds compared to those found from the original plant. Under PDT regimen, we found that cell destruction resulted in a dose-dependent manner and occasioned apoptosis on photosensitized cells. Biochemical analysis revealed the involvement of caspase-3, PARP cleavage and DNA fragmentation in Rubiadin induced apoptosis. Moreover, Soranjidiol-PDT led to &#956;-calpain-induced apoptosis involving caspases-3-independent DNA fragmentation. We also showed that both anthraquinones are cytoplasmatically distributed and out of nucleus. In addition, we demonstrated a synergic cytotoxic effect when we combined them. Our data demonstrated that Rubiadin and Soranjidiol could be further considered as natural photocytotoxic compounds against cancer cells and callus cultures are a plausible source of these anthraquinonic compounds.","palabras_clave":"NATURAL ANTHRAQUINONES|PHOTOSENSITIZERS|PHOTOCHEMOTHERAPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38375,"idioma_id":4,"titulo":"Mechanisms of cellular uptake, intracellular transportation and degradation of CIGB-300, a Tat-conjugated peptide, in tumor cell lines.","resumen":"CIGB-300 is a cyclic synthetic peptide that induces apoptosis in malignant cells, elicits antitumor activity in cancer animal models, and shows tumor reduction signs when assayed in first-in-human phase I trial in patients with cervical tumors. CIGB-300 impairs phosphorylation by casein kinase 2 through targeting the substrate´s phosphoacceptor domain. CIGB-300 was linked to the cell penetrating peptide Tat to facilitate the delivery into cells. Previously, we showed that CIGB-300 had a differential antiproliferative behavior in different tumor cell lines. In this work, we studied differential antiproliferative behavior in terms of cellular uptake, intracellular transportation, and degradation in tumor cell lines with dissimilar sensitivity to CIGB-300. The internalization of CIGB-300 was studied in different malignant cell lines. We found that the cell membrane heparan sulfate proteoglycans act as main receptors for extracellular CIGB-300 uptake. The most sensitive tumor cell lines showed higher intracellular incorporation of CIGB-300 in comparison to less sensitive cell lines. Furthermore, CIGB-300 uptake is time- and concentration-dependent in all studied cell lines. It was shown that CIGB-300 has the ability to penetrate cells mainly by direct membrane translocation. However, a minor proportion of the peptide uses an energy-dependent endocytic pathway mechanism to gain access into cells. CIGB-300 is internalized and transported into cells preferentially by caveolae-mediated endocytosis. Lysosomes are involved in CIGB-300 degradation; highly sensitive cell lines showed degradation at earlier times compared to low sensitive cells. Altogether, our data suggests a mechanism of internalization, vesicular transportation, and degradation for CIGB-300 in tumor cells.","palabras_clave":"CK2 KINASE|CANCER|TAT PEPTIDE|CIGB-300"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38376,"idioma_id":4,"titulo":"Silver Nanoparticle-Mesoporous Oxide Nanocomposite Thin Films: A Platform for Spatially Homogeneous SERS-Active Substrates with Enhanced Stability","resumen":"We introduce a nanoparticle-mesoporous oxide thin film composite (NP-MOTF) as low-cost and straightforward sensing platforms for surface-enhanced Raman Spectroscopy (SERS). Titania, zirconia, and silica mesoporous matrices templated with Pluronics F-127 were synthesized via evaporation-induced self-assembly and loaded with homogeneously dispersed Ag nanoparticles by soft reduction or photoreduction. Both methods give rise to uniform and reproducible Raman signals using 4-mercaptopyridine as a probe molecule. Details on stability and reproducibility of the Raman enhancement are discussed. Extensions in the design of these composite structures were explored including detection of nonthiolated molecules, such as rhodamine 6-G or salicylic acid, patterning techniques for locating the enhancement regions and bilayered mesoporous structures to provide additional control on the environment, and potential size-selective filtration. These inorganic oxide?metal composites stand as extremely simple, reproducible, and versatile platforms for Raman spectroscopy analysis.","palabras_clave":"surface-enhanced Raman spectroscopy|mesoporous thin films|silver nanoparticles|photodeposition"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38377,"idioma_id":4,"titulo":"New Method for the Simultaneous determination of Diffusion and  Adsorption of dyes in Silica Hydrogels","resumen":"The fine tuning of porosity in sol gel based devices makes possible the design of novel applications in which the transport of molecules through the oxide gel plays a crucial role. In this work we develop a new method for the simultaneous analysis of diffusion and adsorption of small   diffusing probes, as anionic and cationic dyes, through silica mesoporous hydrogels synthesized by sol-gel. The novelty of the work resides in the simplicity of acquisition of the experimental data   (by means of a desk scanner) and further mathematical modeling, which is in line with high throughput screening procedures, enabling rapid and simultaneous determination of relevant diffusion and adsorption parameters. Net mass transport and adsorption properties of the silica   based hydrogels were contrasted to dye adsorption isotherms and textural characterization of the wet gels by SAXS, as well as that of the corresponding aerogels determined by Field Emission Scanning Electron Microscopy (FESEM) and N2 adsorption. Thus, the validation of the results with well-established characterization methods demonstrates that our approach is robust enough to give reliable physicochemical information on these systems.","palabras_clave":"Diffusion; |Adsorption; |Solgel; |Silica hydrogel"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38378,"idioma_id":4,"titulo":"High resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase","resumen":"Lipocalin-type prostaglandin D synthase (L-PGDS) catalyzes the isomerization of the 9,11-endoperoxide group of PGH2 (prostaglandin H2) to produce PGD2 (prostaglandin D2) with 9-hydroxy and 11-keto groups. The product of the reaction, PGD2, is the precursor of several metabolites involved in many regulatory events. L-PGDS, the first member of the important lipocalin family to be recognized as an enzyme, is also able to bind and transport small hydrophobic molecules and was formerly known as &#946;-trace protein, the second most abundant protein in human cerebrospinal fluid. Previous structural work on the mouse and human proteins has focused on the identification of the amino acids responsible and the proposal of a mechanism for catalysis. In this paper, the X-ray structures of the apo and holo forms (bound to PEG) of the C65A mutant of human L-PGDS at 1.40 Å resolution and of the double mutant C65A\/K59A at 1.60 Å resolution are reported. The apo forms of the double mutants C65A\/W54F and C65A\/W112F and the triple mutant C65A\/W54F\/W112F have also been studied. Mutation of the lysine residue does not seem to affect the binding of PEG to the ligand-binding cavity, and mutation of a single or both tryptophans appears to have the same effect on the position of these two aromatic residues at the entrance to the cavity. A solvent molecule has also been identified in an invariant position in the cavity of virtually all of the molecules present in the nine asymmetric units of the crystals that have been examined. Taken together, these observations indicate that the residues that have been mutated indeed appear to play a role in the entrance?exit process of the substrate and\/or other ligands into\/out of the binding cavity of the lipocalin.","palabras_clave":"PROSTAGLANDIN|SYNTHASE|LIPOCALIN|CRYSTAL STRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38379,"idioma_id":4,"titulo":"Quantification of the strength of inertial waves in a rotating turbulent flow","resumen":"We quantify the strength of the waves and their impact on the energy cascade in  rotating turbulence by studying the wave number and frequency energy spectrum, and  the time correlation functions of individual Fourier modes in numerical simulations  in three dimensions in periodic boxes. From the spectrum, we &#64257;nd that a signi&#64257;cant  fraction of the energy is concentrated in modes with wave frequency &#969; &#8776; 0, even  when the external forcing injects no energy directly into these modes. However, for  modes for which the period of the inertial waves &#964;&#969; is faster than the turnover time  &#964;NL, a signi&#64257;cant fraction of the remaining energy is concentrated in the modes that  satisfy the dispersion relation of the waves. No evidence of accumulation of energy  in the modes with &#964;&#969; = &#964;NL is observed, unlike what critical balance arguments  predict. From the time correlation functions, we &#64257;nd that for modes with &#964;&#969; < &#964;sw  (with &#964;sw the sweeping time) the dominant decorrelation time is the wave period, and  that these modes also show a slower modulation on the timescale &#964;NL as assumed in  wave turbulence theories. The rest of the modes are decorrelated with the sweeping  time, including the very energetic modes with &#969; &#8776; 0. C 2014 AIP Publishing LLC.  [http:\/\/dx.doi.org\/10.1063\/1.4868280]","palabras_clave":"TURBULENCE|ROTATING FLOWS|SWIRLING FLOWS|DIRECT NUMERICAL SIMULATIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38380,"idioma_id":4,"titulo":"Effect of time of day for harvest and postharvest treatments on the sugar metabolism of broccoli (Brassica oleracea var. italica)","resumen":"Loss of sugars contributes to accelerate postharvest senescence ofbroccoli. Several treatments have been developed to delay senescence, but inmany cases their effects on sugar metabolism were not analyzed. We studied theeffect of harvest at different times of day (08:00, 13:00 and 18:00 h) and ofseveral postharvest treatments (heat treatment -HT-, modified atmosphere -MA-and 1-methylcylcopropene -1-MCP-) on sugar levels and activities of enzymesrelated to sucrose and starch degradation. Harvesting at the end of day delayedthe loss of chlorophylls and caused the lowest decrement in sugars, although nodifferences in invertase, sucrose synthase and &#946;-amylase activities weredetected among samples. Treatments of MA and 1-MCPcaused a lower loss ofglucose and fructose, while HT caused a lower decrement of sucrose. The samplestreatedmaintained higher levels of chlorophylls. The treatments reduced theactivity of invertase and sucrose synthase and induced higher levels of&#946;-amylase activity. Harvesting at the end of day and performing simultaneouslya MA treatment could be a good combination to maintain the green color of theinflorescence and sugar levels during postharvest of broccoli.","palabras_clave":"INVERTASE|SUCROSE SYNTHASE|B-AMYLASE|SENESCENCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38381,"idioma_id":5,"titulo":"Comportamiento eléctrico de vidrios funcionales con base en TeO2","resumen":"En este trabajo estudiamos la estructura de un material vítreo cuya fórmula general es: xMgO(1-x)(0.5V2O5.0.5MoO3)2TeO2 (0&#8804;x&#8804;0.9), mediante medidas de densidad, volumen molar, empaquetamiento denso de oxigeno (OPD), calorimetría diferencial de barrido (DSC) y espectroscopia Raman; el comportamiento eléctrico se estudió por medio de&nbsp; espectroscopia de impedancia. Encontramos que el catión magnesio induce el crecimiento de zonas levemente cristalizadas dentro del material. Dichas nanocristalizaciones pudieron ser detectadas en mayor medida por microscopia de fuerzas atómicas (AFM) y en menor medida se pudo observar en los patrones de difracción de Rayos X (DRX). Con respecto a las propiedades eléctricas, se puede establecer que el catión magnesio no actúa como buen conductor iónico en este material.","palabras_clave":"vidrios de TeO2|semiconductores|conductividad ionica|espectroscopia de impedancia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38382,"idioma_id":5,"titulo":"Respuesta Ferro-Piezoeléctrica de (K, Na, Li)(Nb, Ta, Sb)O3 poroso","resumen":"Polvo de KNL-NTS con estequiometria (K 0.44 Na0.52 Li0.04 )(Nb0.86 Ta0.10 Sb0.04 )O3fue preparado siguiendo el método convencional cerámico de mezcla de carbonatos y óxidos. La&nbsp; síntesis del polvo de KNL-NTS fue llevada a cabo en estado sólido a 700 ºC durante 3h. Para obtener muestras cerámicas con diferente porosidad, se llevó a cabo la sinterización de pastillas en un rango de temperaturas entre 1088 y 1125 ºC durante 2h en aire. Las muestras fueron&nbsp; caracterizadas estructural y microestructuralmente mediante DRX y MEB, y se determinó el grado y tipo de porosidad mediante porosimetría de intrusión de mercurio. Se investigó la influencia de la temperatura de sinterización en la porosidad y se evaluó el impacto de la misma en los ciclos de histéresis ferroeléctricos y la respuesta piezoeléctrica de las pastillas. La máxima densificación del material se consigue a 1125 ºC y la mejor respuesta ferroeléctrica, en pastillas sinterizadas a 1112ºC. Por su parte, se observó que pastillas fabricadas en un rango de temperaturas inferior&nbsp; (1094-1100 ºC) donde la porosidad alcanza valores de hasta 15 % presentan buena respuesta&nbsp; piezo-ferroeléctrica, similar a la encontrada en las pastillas sinterizadas a 1125 ºC.&nbsp;","palabras_clave":"piezoeléctricos libres de plomo|porosidad|propiedades ferroelectricas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38383,"idioma_id":5,"titulo":"Niveles piroclásticos como herramientas de correlación en los depósitos Cenozoicos del Grupo Payogastilla, Tonco y Amblayo, Noroeste Argentina","resumen":"Los estudios texturales, mineralógicos y geoquímicos realizados en  tobas del Grupo Payogastilla (Cenozoico) en los valles   Calchaquí, Tonco y Amblayo, Salta, Argentina, han permitido  discriminar distintos grupos con características afines, reconociéndose   así trazadores cronoestratigráficos, que se corresponden con las  formaciones Angastaco, Palo Pintado y San Felipe.   Los análisis geoquímicos han sido un factor clave en dicha  discriminación, permitiendo encuadrar a las tobas como calcoalcalinas,   con contenidos medios en K en las formaciones Angastaco y Palo  Pintado, a altos en las secuencias más jóvenes (Formación   San Felipe). La composición riodacítica-dacítica y  traquiandesítica caracteriza a las tobas del Grupo Payogastilla, con   exiguos representantes andesíticos en el caso de la Formación Angastaco.  La química de estas piroclastitas indica características   típicas de magmas de arco, con similares contenidos en tierras  raras livianas (La\/Sm=4-6,2) y distinto diseño de sus tierras   pesadas (HREE), con un enriquecimiento creciente desde aquellas de  la Formación   Angastaco (Sm\/Yb=1,6-2,4) a las de la   Formación Palo Pintado (Sm\/Yb=3,9-4,1), y a las de la Formación San Felipe  (Sm\/Yb=4,0-5,6). El análisis de sus características   geoquímicas, mineralógicas y de edades publicadas ha servido de  guía para postular potenciales centros emisores, como   la caldera Agua Escondida y su ignimbrita (15-13 Ma), en el caso  de tobas de la   Formación Angastaco, a centros volcánicos del   Sistema Calama-Olacapato-El Toro (10-7 Ma), en el de la Formación Palo  Pintado, y a la Caldera  del Cerro Galán (ignimbritas   del Grupo Toconquis e Ignimbrita Cueva Negra: 6-3 Ma) en el de la Formación San  Felipe.","palabras_clave":"TOBAS|TRAZADORES CRONOESTRATIGRAFICOS|DEPÓSITOS CENOZOICOS|CUENCA DE ANTEPAÍS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38384,"idioma_id":4,"titulo":"Tectonic controls on the evolution of the Andean Cenozoic foreland basin: evidence from fluvial system variations in the Payogastilla Group, in the Calchaquí, Tonco, and Amblayo Valleys, NW Argentina.","resumen":"The stratigraphic and sedimentological characteristics of the Payogastilla Group represent important tectono-sedimentary constraints on the evolution of the Andean foreland basin in northwestern Argentina. This nonmarine unit unconformably rests on top of the post-rift deposits of the middle Eocene Lumbrera Formation of the Santa Bárbara Subgroup (Salta Group). Eocene-Pliocene paleoenvironmental changes are a direct result of the tectonic settings and accommodation space. Sequential stratigraphic analysis of the paleoenvironment of the Los Colorados Formation strata indicates the presence of three third-order sequences. Each sequence comprises a low-accommodation systems tract (LAST) and a highaccommodation systems tract (HAST). Substantial tectonic activity from the middle to upper Miocene is represented by Angastaco Formation strata that contain a shallow, gravel-braided fluvial system associatedwith gravity flows, with thicknesses of 4550 m (Calchaquí River) to 1500 m (Tonco). This activity marked the depocenter of the Angastaco basin. The development of a basal unconformity and the erosion of the Los Colorados Formation suggest a renewed uplift of the source area. Changes in the fluvial systems indicate an increase of the accommodation space.To obtain better temporal constraints on the basin evolution, new UePb ages on zircons from five pyroclastic airfall and two sedimentary levels were determined. A substantial environmental change in the upper Miocene (10e5 Ma) is associated with three episodes of tectonic uplift that are reflected in variations in the sedimentation rates of the Palo Pintado Formation. A reactivated Pliocene tectonic uplift is recorded in alluvial fans that originated from the east.","palabras_clave":"Payogastilla Group|Foreland Basin|Sequence stratigraphic|Paleoenviromental|Fluvial system"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38385,"idioma_id":5,"titulo":"El Grupo Payogastilla (Cenozoico) en los valles Calchaquí, Tonco y Amblayo, provincia de Salta, Argentina.","resumen":"Las características estratigráficas y sedimentológicas de los depósitos del Grupo Payogastilla son aspectos muy importantes a tener en cuenta para investigar la evolución tecto-sedimentaria de la cuenca de antepaís andino en el noroeste de la Argentina. El límite estratigráficoinferior del Grupo Payogastilla está marcado por una paraconcordancia con los depósitos de post-rift de la Formación Lumbrera (Subgrupo Santa Bárbara, Grupo Salta). El límite estratigráfico superior de la Formación Los Colorados, es paraconcordante y discordante; la subsidencia de la cuenca fue pareja entre ~35 a 21 Ma. En el Mioceno medio a superior, los depósitos de la Formación Angastaco, con espesores de 4550 m (río Calchaquí) y 1500 m (Tonco) reflejan una importante influencia tectónica, la que delimitó el depocentro de la cuenca de Angastaco,con un inicio en el valle El Tonco (>13,7 Ma) y posteriormente en el valle Calchaquí (~13 Ma).Con posterioridad a los ~13 Ma se habrían desarrollado incipientes barreras orográficas en el este (sierras Los Colorados y León Muerto), que durante el Mioceno superior (10 a 5 Ma) se habrían reactivado para formar cadenas orográficas importantes. Durante el Plioceno se habríanreactivado nuevamente los alzamientos tectónicos, generando sistemas fluviales entrelazados gravosos, con una marcada proveniencia desde el este. Los niveles de tobas intercalados en los depósitos de las formaciones Angastaco y Palo Pintado, muestran una clara signatura de arco indicando su proveniencia del arco activo a esos tiempos, con características que indican una componente cortical participante en sus magmas. Mientras que, los niveles piroclásticos intercalados en la Formación San Felipe, por su mayor carácter peraluminoso y sus menores contenidos en Na20 respecto a K20, que las ubican en el campo de los granitos tipo S, dando idea de componentes corticales distintas.","palabras_clave":"Estratigrafía|Cenozoico|Cuenca de Antepaís|Proveniencia|Geoquímica de Tobas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38386,"idioma_id":4,"titulo":"Caiman cf. latirostris (alligatoridae, caimaninae) in the late Miocene of the Palo Pintado Formation, Salta province, Argentina: paleogeographic and paleoenvironmental considerations","resumen":"The three recognized species of Caiman ?C. latirostris, C. yacare and C. crocodilus? currently live in northern and central South America. Except for the fragmentary dentary of a putative Caiman from Oligocene rocks in Brazil, the genus has been reliably recorded in rocks of ages spanning the Neogene, when species of Caiman were a constant component of the South American crocodyliofauna. The major taxonomical diversification of Caiman occurred during the late Miocene, which is well documented in the area of Paraná (northeastern Ar- gentina). Fossil crocodylians in Paraná are represented by one gavialid and caimanines, with at least five species of Caiman (including C. la- tirostris). This assemblage represents the southernmost record of Crocodylia living in 'Amazonia' during the Miocene. In this work we confirm the record of Miocene caimans outside the Paraná and we prove the presence of Caiman cf. latirostris in present-day northwestern Argentina during the late Miocene. The taxonomic identification is based on a fragment of a left mandible with the same ornamentation, outline and dentition as Caiman, and with a symphyseal morphology similar to that of Caiman latirostris. The material comes from the upper part of the Palo Pintado Formation in the southern region of Valle Calchaquí (Salta Province). This unit was deposited in a sand-gravel flu- vial system with associated ponds between 10.29 ±0.11 Ma (K\/Ar) and 5.27 ±0.28 Ma (206Pb\/238U).","palabras_clave":"Crocodylia|Caiman|Neógeno|provincia de Salta|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38387,"idioma_id":4,"titulo":"Gene therapy and cell reprogramming for the aging brain: achievements and promise","resumen":"In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during normal aging as well as severe atrophy in Alzheimer´s disease (AD). Parkinson´s disease (PD), a degeneration of nigro-striatal DA neurons is the most conspicuous reflection of the vulnerability of DA neurons to age. Overall, there is growing evidence that a progressive decline in cognitive function and central DA activity represents basic features of normal aging both in humans and laboratory rodents. Spontaneous or environmental neurotoxin-mediated exacerbation of these processes contributes to the symptoms of AD and PD, respectively. In this context, neurotrophic factors that can prevent or delay the decline in cognitive function and central DA activity are of clinical interest. Among them, Insulin-like Growth Factor I and Glial cell line-Derived Neurotrophic Factor are emerging as powerful neuroprotective molecules. This article discusses the experimental evidence supporting the neuroprotective relevance of these and related factors in the aging brain. The availability of induced pluripotent stem cells offers a new promise for the treatment of pathologies associated with the loss of specific cell types as for instance, nigral DA neurons (in PD) or basal forebrain cholinergic neurons (BFCN) in the early stages of AD. Recent studies documenting the use of cell reprogramming for the generation of multipotent neuronal precursors as well as functional BFCN and DA neurons are reviewed.","palabras_clave":"Aging|alzheimer|gene therapy|cell reprogramming|Parkinson|neurodegeneration|neurotropic factors|transdifferentiation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38388,"idioma_id":4,"titulo":"Geometrical guidance and trapping transition of human sperm cells","resumen":"The guidance of human sperm cells under confinement in quasi-2D microchambers is investigated usinga purely physical method to control their distribution. Transport property measurements and simulations areperformed with diluted sperm populations, for which effects of geometrical guidance and concentration arestudied in detail. In particular, a trapping transition at convex angular wall features is identified and analyzed.We also show that highly efficient microratchets can be fabricated by using curved asymmetric obstacles to takeadvantage of the spermatozoa specific swimming strategy.","palabras_clave":"espermatozoides|atrapamiento|ratchets|microconfinamiento"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38389,"idioma_id":5,"titulo":"EFECTO DE LA TEMPERATURA DE CONSERVACIÓN SOBRE LA EXPRESIÓN DE PROTEINAS EN GRANOS DE POLEN DE CHENOPODIUM ALBUM L.","resumen":"ResumenLos componentes activos del polen a partir del cual se obtienen los extractos alergénicos pueden variar considerablemente de acuerdo al momento, el lugar dónde se recolecta y el período comprendido entre la recolección y su utilización.El presente trabajo pretende evaluar si la temperatura de conservación del grano de polen influye en la expresión de proteínas y en la antigenicidad de las mismas, al momento de preparar un extracto alergénico. La especie elegida para estudio fue Chenopodium album L. ya que es de gran interés alergológico en la ciudad de Bahía Blanca.  Los granos de polen se conservaron a temperatura ambiente, 4 °C y -18 °C por el término de dos meses. El contenido proteico de los extractos se determinó por el Método de Bradford. La expresión proteica y la antigenicidad se estudiaron mediante electroforesis vertical Tricina-PAGE-SDS 12, 5 % e Inmunoblot respectivamente.Los resultados obtenidos demuestran que la concentración proteica total fue menor para los extractos obtenidos del polen conservado a temperatura ambiente que para las otras dos condiciones. La expresión de proteínas varía cuantitativamente en todos los extractos y si bien la expresión cualitativa prácticamente se conserva, aparece para el polen conservado a temperatura ambiente, una banda de PM menor a 12 kDa. Esta banda podría ser consecuencia de la degradación proteica que experimenta el polen a esa temperatura de almacenamiento. En cuanto a la antigenicidad de los extractos no hay diferencias cualitativas aunque pueden apreciarse diferencias cuantitativas significativas.Concluimos que la conservación del polen a 4°C o a -18°C serían las más adecuadas, ya que permiten obtener una mayor concentración proteica partiendo de la misma masa de polen.","palabras_clave":"Chenopodium álbum |Temperatura de conservación|Aeroalérgenos, |Extractos alergénicos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38390,"idioma_id":4,"titulo":"Detrimental effects of volcanic ash deposition on bee fauna and plant-pollinator interactions","resumen":"Volcanic eruptions are large-scale natural disturbances, which can negatively affect insect fauna  and the ecological interactions in which they are involved. The 2011 eruption of the volcanic complex Puyehue  Cordón-Caulle (PCC) produced the deposition of 950 million tons of ash on Argentine Patagonia, creating an ash  layer of varying thickness. Although experimental studies confirmed that PCC volcanic ash negatively affects  survival and behavior in many insect taxa, including bees, the effects of ash deposition on the plant-pollinator  interactions (PPI) of this group of insects in natural landscapes remained untested. We evaluated the effect of  the gradient of increasing ash layer thickness (0-15cm) on: (1) number of wild bees visiting flowers and total  bee richness in 16 raspberry fields after the eruption, (2) number of native (Bombus dahlbomii) and invasive (B.  terrestris and B. ruderatus) bumble bees foraging on wild flowers in 10 sites before and after the eruption, and  (3) the proportion of ?triggered? flowers (i.e. papilionaceous flowers visited for first time by large bees) in  32 populations of the invasive shrub scotch broom (Cytisus scoparius), before and after the eruption. With the  increase of ash deposition, we found a consistent and significant decrease in (1) the number of wild bees and  total bee richness visiting raspberry flowers; (2) the number of bumble bees, particularly B. terrestris, visiting  wild flowers; and (3) the proportion of triggered flowers of scotch broom. Thus, volcanic eruptions can exert a  detrimental effect on bee fauna and concomitant PPI, with a potential cascade effect on the pollination service  to crops, the spread of invasive bumble bees, and the pollination success of invasive plants.","palabras_clave":"BUMBLE BEES|LARGE SCALE DISTURBANCE|POLLINATION|PUYEHUE CORDÓN-CAULLE VOLCANO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38391,"idioma_id":5,"titulo":"Clima, distribución geográfica y viviparismo en especies de Liolaemus (Reptilia; Squamata): cuando las hipótesis se ponen a prueba","resumen":"La distribución de los reptiles, dada su dependencia de la temperatura, puede verse restringida en función del clima. En particular, se han planteado tres hipótesis que vinculan el clima con el viviparismo en las especies de reptiles: i) hipótesis de clima variable, ii) hipótesis del clima frío e iii) hipótesis de manipulación materna. Entre las lagartijas de Sudamérica las especies del género Liolaemus se distribuyen tanto en ambientes cálidos como fríos y más del 50% de ellas son vivíparas. En este trabajo estudiamos 47 especies de Liolaemus, tomando datos climáticos de sus sitios de colecta, su temperatura de preferencia (Tpref), el coeficiente de variación de la misma (CV) y los límites de tolerancia térmica (TT). Nuestros resultados no apoyan la hipótesis de clima variable, aunque ésta ha sido sustentada en estudios anteriores. Se encontró relación entre viviparismo y altitud, pero no entre viviparismo y las variables térmicas ambientales. Finalmente, las especies vivíparas de Liolaemus mostraron un comportamiento termorregulador más preciso que las especies ovíparas, reforzando la hipótesis de manipulación materna.","palabras_clave":"CLIMA|DISTRIBUCION|LIOLAEMUS|REPTILES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38392,"idioma_id":4,"titulo":"A New Species of Liolaemus (Iguania: Liolaemidae) of the alticolor-bibronii Group from Northern Chile","resumen":"We describe a new slender species of Liolaemus of the L. alticolor-bibronii group of the subgenus Liolaemus. The new species is pheneticallyand biogeographically close to L. alticolor, L. paulinae, and L. puna but presents a combination of character states that differentiatesit from all other species of Liolaemus. The new taxon is the first species of subgenus Liolaemus sensu stricto recorded as having supernumerarypores. The new species inhabits places where Parastrephia lucida is the predominant flora and is distributed in areas close to Putre, in theArica y Parinacota region, northern Chile. Data on its biology, complete distribution, and conservation status are lacking.","palabras_clave":"Chile|Lizard|New species|South America|Squamata|Taxonomy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38393,"idioma_id":4,"titulo":"Semantic Memory Organization In Children And Young Adults","resumen":"The study of the organization of semantic memory has become of great interest in the cognitive psychology field and in   neuropsychological research. Semantic knowledge considered to be represented by concepts, which can be related taxonomically   (when they are hierarchically organized) or thematically (when they are linked by cross-categorical relations). Both relations   arise from distinct processes, as evidenced by numerous neuropsychological and behavioral dissociations. Many works have   stated that the production of thematic relations outnumbers that of taxonomic relations in children, and that as they grow older a   thematic-to-taxonomic shift occurs, while others claim that such a shift does not take place and state that one major problem is   that the tasks used in previous studies to assess concept-relations are biased. In our work we performed a feature production task   in such a way that subjects could freely associate concepts with their features. Our results, using this non-biased-task, show that   the evocation of taxonomic relations was higher in the adult group (formed by thirty 20-to 40-year-olds) compared to the children   group (formed by forty-eight 6-to 9-year-olds), but that, nonetheless, thematic relations were still present in the adult group. This   suggests, instead of a thematic-to-taxonomic shift in adulthood, the coexistence of both types of relations, which is crucial to   research on language structure and conceptual knowledge. Thus, our results contribute to the understanding of semantic   knowledge organization and provide valuable groundwork to the development of clinical instruments used in neuropsychological   tests to assess language, attention and semantic memory, where precise information of concept-relations is crucial.","palabras_clave":"COGNITIVE PSYCHOLOGY|CONCEPTS|TAXONOMIC RELATIONS|THEMATIC RELATIONS|EVOCATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38394,"idioma_id":4,"titulo":"Synthesis, structural characterization and magnetic properties  of the monoclinic ordered double perovskites BaLaMSbO6, with M = Mn, Co and Ni.","resumen":"P { margin-bottom: 0.21cm; }                    Double perovskites BaLaMnSbO6,  BaLaCoSbO6 and BaLaNiSbO6, were synthesized by conventional ceramic  method in air, as polycrystalline powders. The Mn and Ni compounds  belong to the I 2\/m monoclinic space group, while the Co perovskite  belongs to the I 4\/m tetragonal space group. Effective presence of  Mn2+ has been well established by X-ray emission spectroscopy for BaLaMnSbO6, and there is no evidence of  Mn3+. BaLaCoSbO6 and BaLaNiSbO6 only show the expected  3D-antiferromagnetic behaviour typical of super-superexchange  interactions, while BaLaMnSbO6 displays signs of superparamagnetism  in the 40-160 K range, which arises from unbalanced  antiferromagnetism inside nanoclusters formed by regions which are  rich in Mn2+ &#8213; O2- Mn2+ paths. Neutron powder diffraction data for  BaLaMnSbO6 reveals that at 3 K, only long range order  antiferromagnetic arrangement of Mn2+ spins on 2d octahedral sites is  obtained.  ","palabras_clave":"SYNTHESIS|STRUCTURE|MAGNETISM|BaLaMSbO6|ORDERED|PEROVSKITE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38395,"idioma_id":4,"titulo":"Fossil pollen records indicate that Patagonian desertification was not solely a consequence of Andean uplift","resumen":"    The Patagonian steppe?a massive rain-shadow on the lee side of the southern Andes?is    assumed to have evolved B15?12 Myr as a consequence of the southern Andean uplift.    However, fossil evidence supporting this assumption is limited. Here we quantitatively    estimate climatic conditions and plant richness for the interval B10?6 Myr based on the    study and bioclimatic analysis of terrestrially derived spore?pollen assemblages preserved in    well-constrained Patagonian marine deposits. Our analyses indicate a mesothermal climate,    with mean temperatures of the coldest quarter between 11.4 !C and 16.9 !C (presently    B3.5 !C) and annual precipitation rarely below 661mm (presently B200 mm). Rarefied    richness reveals a significantly more diverse flora during the late Miocene than today at the    same latitude but comparable with that approximately 2,000 km further northeast    at mid-latitudes on the Brazilian coast. We infer that the Patagonian desertification was not    solely a consequence of the Andean uplift as previously insinuated.","palabras_clave":"MIOCENE|PALYNOLOGY|DESERTIFICATION|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38396,"idioma_id":4,"titulo":"Role of PFC during retrieval of recognition memory in rodents","resumen":"One of the challenges for memory researches is the study of the neurobiology of episodic memory which is defined by the integration of all the different components of experiences that support the conscious recollection of events. The features of episodic memory includes a particular object or person ('what'), the context in which the experience took place ('where') and the particular time at which the event occurred ('when'). Although episodic memory has been mainly studied in humans, there are many studies that demonstrate these features in non-human animals. Here, we summarize a set of studies that employ different versions of recognition memory tasks in animals to study the role of the medial prefrontal cortex in episodic memory.","palabras_clave":"PREFRONTAL CORTEX|OBJECT RECOGNITION|EPISODIC MEMORY|RODENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38397,"idioma_id":4,"titulo":"Acetohydroxyacid synthase activity and transcripts profiling reveal tissue-specific regulation of ahas genes in sunflower","resumen":"Acetohydroxyacid synthase (AHAS) is the target site of several herbicides and catalyzes the first step in the biosynthesis of branched chain amino acid. Three genes coding for AHAS catalytic subunit (ahas1, ahas2 and ahas3) have been reported for sunflower. The aim of this work was to study the expression pattern of ahas genes family and AHAS activity in sunflower (Helianthus annuus L.). Different organs (leaves, hypocotyls, roots, flowers and embryos) were evaluated at several developmental stages. The transcriptional profile was studied through RT-qPCR. The highest expression for ahas1 was shown in leaves, where all the induced and natural gene mutations conferring herbicide resistance were found. The maximal expression of ahas2 and ahas3 occurred in immature flowers and embryos. The highest AHAS activity was found in leaves and immature embryos. Correlation analysis among ahas gene expression and AHAS activity was discussed. Our results show that differences in ahas genes expression are tissue-specific and temporally regulated. Moreover, the conservation of multiple AHAS isoforms in sunflower seems to result from different expression requirements controlled by tissue-specific regulatory mechanisms at different developmental stages.","palabras_clave":"acetohydroxyacid synthase|AHAS activity|ahas genes|gene expression|Helianthus annuus L.|sunflower"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38398,"idioma_id":4,"titulo":"Ion neutralization and high-energy electron emission in He+ scattering by a highly oriented pyrolitic graphite surface","resumen":"We report results of ion neutralization of low energy positive He ions interacting with a surface of highly-oriented pyrolitic graphite (HOPG), as a function of the impinging energy. We found a neutralization probability close to unity for a wide energy range. This behavior is reproduced by our theory only if we take into account the electronic correlation introduced by the He first excited states considered as possible neutralization channels. The finite occupation of these excited states opens the Auger de-excitation process as a source of emitted electrons. The calculation of this electron emitted spectrum is complex as it requires the knowledge of the energies and occupations of the atomic configurations as a function of the ion trajectory. Our calculation shows the presence of high energetic secondary electrons contributing to the Auger electron emission spectra of this system [N. Bajales, L. Cristina, S. Mendoza, R. A. Baragiola, E. C. Goldberg, and J. Ferrón , Phys. Rev. Let. 100, 227604 (2008)].","palabras_clave":"ION NEUTRALIZATION|ELECTRON EMISSION|GRAPHITE|ION SCATTERING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38399,"idioma_id":4,"titulo":"Light responsive thin films of micelles of PS-b-PVP complexed with diazophenol chromophore","resumen":"We have incorporated push-pull azobenzene units into diblock-copolymer micelles by supramolecular assembly. Specifically, we encapsulated a phenol-functionalized chromophore, DO13, within PS-b-P4VP micelles in toluene by means of H-bond interactions developed between DO13 molecules and pyridine groups of P4VP block. The solutions were spin-coated onto glass substrates to result in multi- or mono-layered thin films of micelles with P4VP(DO13) core and PS corona. We showed that the use of DO13 as building block of micellar aggregates allow us to manipulate the developed nanostructures. Spherical to cylindrical micellar transition was found when we increased the degree of chromophore complexation. Besides, it was found that the polymer concentration in the solution plays an important role in determining the micellar nanostructures. The chain extension and change in composition of the P4VP core in the presence of the chromophore, may be responsible for the structural changes observed in the micelles. The optical properties of the thin films have been investigated focusing on the effect of the micellar morphology over the photo-induced birefringence. The optical anisotropy  increased with respect to the analogous homogenous system P4VP(DO13) indicating that the protective micelle environment can enhance the optical properties of the embedded chromophores significantly. Besides, we showed very interesting new results in which we have related changes in optical properties with the film morphology (spheres to cylinders). This can be exploited for producing optical devices having improved optoelectronic properties and stability.","palabras_clave":"azopolymers|block copolymer|micelles|photoinduced birefringence|supramoelcular interactions"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38400,"idioma_id":4,"titulo":"Structural Characterization of Heparin-induced GAPDH Protofibrils Preventing &#945;-synuclein Oligomeric Species Toxicity","resumen":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that has been associated to neurodegenerative diseases. GAPDH colocalizes with &#945;-synuclein in amyloid aggregates in post-mortem tissue of patients with sporadic Parkinson disease and promotes the formation of Lewy body-like inclusions in cell culture. In a previous work, we showed that glycosaminoglycans-induced GAPDH prefibrilar species accelerates the conversion of &#945;-synuclein to fibrils. However, it remained to be determined whether the interplay among glycosaminoglycans, GAPDH and &#945;-synuclein has a role in pathological states. Here we demonstrate that the toxic effect exerted by &#945;-synuclein oligomers in dopaminergic cell culture is abolished in the presence of GAPDH prefibrilar species.Structural analysis of prefibrilar GAPDH performed by Small angle&nbsp; X-ray scattering, showed a particle compatible with a protofibril. This protofibril is shaped as a cylinder 22 nmlong and cross-section diameter of 12 nm. Using biocomputational techniques we obtained the first all-atom model of the GAPDH protofibril, which was validated by cross-linking coupled to mass spectrometry experiments. Since GAPDH can be secreted outside the cell where glycosaminoglycans are present, it seems plausible that GAPDH protofibrils could be assembled in the extracellular space kidnapping &#945;-synuclein toxic oligomers. Thus, the role of GAPDH&nbsp; protofibrils in neuronal proteostasis must be considered. The data reported herein could open alternative ways in development of therapeutic strategies against synucleinopathies like Parkinson?s disease.","palabras_clave":"Alpha-synuclein|Parkinson's disease|Protein aggregation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38401,"idioma_id":4,"titulo":"Spectroelectrochemical studies of poly(N-methylaniline) formation, redox behaviour and degradation. A comparison with polyaniline","resumen":"Spectroelectrochemical methods, in-situ Fourier Transform Infrared   (FTIR) and Differential Electrochemical Mass Spectroscopy (DEMS), are   used to study the formation of poly(N-methylaniline) (PNMANI) by anodic oxidation of N-methylaniline   (NMANI). The methods are used to elucidate the structural changes   during redox switching of PNMANI and the nature of the degradation   products of PNMANI produced during electrochemical oxidation. The   results are discussed in comparison with those previously reported for   aniline. The early stages of NMANI oxidation leads to the formation of   dimers by head-to-tail coupling (product&nbsp;=&nbsp;N,N?-dimethyl-4-aminodiphenylamine, DMADA) and tail-to-tail coupling (product&nbsp;=&nbsp;N,&#323;-dimethylbenzidine, DMBz). It seems that, when N-methylaniline   is oxidized, it is formed more tail-to-tail dimer than in the case of   aniline, due to steric and electronic effects of the N-substituent   methyl groups. The head-to-tail dimer (DAMADA) is irreversibly adsorbed   on the electrode surface. The elucidation of the reaction mechanism is   aided by electrochemical and in-situ spectroelectrochemical studies of N,&#323;-dimethylaniline which can only give the tail-to-tail dimer (N,N,&#323;,&#323;-tetramethylbenzidine, TMB). The in-situ FTIR study of redox behaviour of poly(N-methylaniline) shows that quinonimine units are produced during oxidation. The intensity of the band at 1196&nbsp;cm&#8722;1, assigned to C-N+ stretching in the -C-N+-CH3   moiety, increases due to an increased substituted imine content in the   oxidized film. An increase of the anion (perchlorate) concentration   inside the film, due to compensation of the positive charges formed   during oxidation, is also detected by FTIR. CO2 formation is observed by FTIR during NMANI oxidation and in electrochemically induced polymer degradation. The formation of CO2   is confirmed by DEMS. Additionally, during degradation, indophenol like   molecules together with quinone, are produced as the final organic   degradation product.","palabras_clave":"In-situ infrared spectroscopy|Mass spectroscopy|Poly(N-methylaniline)| Oxidation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38402,"idioma_id":4,"titulo":"Macroporous carbon as support for PtRu catalysts","resumen":"A high surface macroporous porous carbon (MPC) has been obtained by SiO2 nanoparticles template and further used as support for PtRu catalysts. MPC supported PtRu materials show an enhanced activity for methanol electrooxidation when compared with commercial catalysts. This observation is discussed in terms of reactant accessibility to active sites. The improved diffusion through the porous matrix influences not only methanol feeding, but also removal of reaction subproducts, as clearly shown by differential electrochemical mass spectrometry (DEMS).","palabras_clave":"Macroporous porous carbon|Direct methanol fuel cells|Methanol electro-oxidation|PtRu electrocatalysts"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38403,"idioma_id":4,"titulo":"Design of novel urogenital pharmabiotic formulations containing lactobacilli, salivaricin CRL 1328 and non-microbial compounds with different functionalities","resumen":"Abstract  Context: The administration of pharmabiotics is a promising alternative to antimicrobial drugs for the treatment and\/or prevention of female urogenital infections.  Objective: To design pharmabiotic formulations including bioactive ingredients of microbial origin combined with non-microbial substances and then to evaluate the stability of the combinations during freeze-drying and storage.   Materials and Methods: Different formulations including Lactobacillus gasseri CRL 1263, Lactobacillus salivarius CRL 1328, salivaricin CRL 1328 (a bacteriocin) and non-microbial compounds (lactose, inulin and ascorbic acid) were assayed and the ingredients were freeze-dried together or separately. The formulations were stored in gelatin capsules at 4ºC for 360 days.   Results: The viability of lactobacilli was affected to different extents depending on the strains and on the formulations assayed. L. salivarius and ascorbic acid were successfully combined only after the freeze-drying process. Salivaricin activity was not detected in formulations containing L. gasseri. However, when combined with ascorbic acid, lactose, inulin or L. salivarius, the bacteriocin maintained its activity for 360 days.  The selected microorganisms proved to be compatible for their inclusion in multi-strain formulations together with lactose, inulin and ascorbic acid. Salivaricin could be included only in a L. salivarius CRL 1328 single-strain formulation together with non-microbial substances.  Conclusions: This study provides new insights into the design of urogenital pharmabiotics combining beneficial lactobacilli, salivaricin CRL 1328 and compounds with different functionalities.","palabras_clave":"BACTERIOCINA|BIOFARMACEUTICOS|PROBIOTICOS|INFECCIONES UROGENITALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38404,"idioma_id":4,"titulo":"Effects of Oligoelements Se, Zn and Mn plus Lachesis Muta Venom in Experimental Scleroderma","resumen":"Oligoelements prevent experimental oxidative stress induced by bleomicine in rats.","palabras_clave":"Scleroderma|Oligoelements|Bleomycin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38405,"idioma_id":4,"titulo":"Biomonitoring of airborne particulate matter emitted from a cement plant and comparison with dispersion modelling results","resumen":"The influence of a cement plant that incinerates industrial waste on the air quality of a region in theprovince of Córdoba, Argentina, was assessed by means of biomonitoring studies (effects of immission)and atmospheric dispersion (effects of emission) of PM10 with the application of the ISC3 model (IndustrialSource Complex) developed by the USEPA (Environmental Protection Agency). For the biomonitoringstudies, samples from the epiphyte plant Tillandsia capillaris Ruíz &amp; Pav. f. capillaris weretransplanted to the vicinities of the cement plant in order to determine the physiological damage andheavy metal accumulation (Ca, Mn, Fe, Co, Ni, Cu, Zn, Cd and Pb). For the application of the ISC3 model,point and area sources from the cement plant were considered to obtain average PM10 concentrationresults from the biomonitoring exposure period. This model permitted it to be determined that theemissions from the cement plant (point and area sources) were confined to the vicinities, without significantdispersion in the study area. This was also observed in the biomonitoring study, which identifiedCa, Cd and Pb, pH and electric conductivity (EC) as biomarkers of this cement plant. Vehicular trafficemissions and soil re-suspension could be observed in the biomonitors, giving a more complete scenario.In this study, biomonitoring studies along with the application of atmospheric dispersion models,allowed the atmospheric pollution to be assessed in more detail.fluence of a cement plant that incinerates industrial waste on the air quality of a region in theprovince of Córdoba, Argentina, was assessed by means of biomonitoring studies (effects of immission)and atmospheric dispersion (effects of emission) of PM10 with the application of the ISC3 model (IndustrialSource Complex) developed by the USEPA (Environmental Protection Agency). For the biomonitoringstudies, samples from the epiphyte plant Tillandsia capillaris Ruíz &amp; Pav. f. capillaris weretransplanted to the vicinities of the cement plant in order to determine the physiological damage andheavy metal accumulation (Ca, Mn, Fe, Co, Ni, Cu, Zn, Cd and Pb). For the application of the ISC3 model,point and area sources from the cement plant were considered to obtain average PM10 concentrationresults from the biomonitoring exposure period. This model permitted it to be determined that theemissions from the cement plant (point and area sources) were confined to the vicinities, without significantdispersion in the study area. This was also observed in the biomonitoring study, which identifiedCa, Cd and Pb, pH and electric conductivity (EC) as biomarkers of this cement plant. Vehicular trafficemissions and soil re-suspension could be observed in the biomonitors, giving a more complete scenario.In this study, biomonitoring studies along with the application of atmospheric dispersion models,allowed the atmospheric pollution to be assessed in more detail.10 with the application of the ISC3 model (IndustrialSource Complex) developed by the USEPA (Environmental Protection Agency). For the biomonitoringstudies, samples from the epiphyte plant Tillandsia capillaris Ruíz &amp; Pav. f. capillaris weretransplanted to the vicinities of the cement plant in order to determine the physiological damage andheavy metal accumulation (Ca, Mn, Fe, Co, Ni, Cu, Zn, Cd and Pb). For the application of the ISC3 model,point and area sources from the cement plant were considered to obtain average PM10 concentrationresults from the biomonitoring exposure period. This model permitted it to be determined that theemissions from the cement plant (point and area sources) were confined to the vicinities, without significantdispersion in the study area. This was also observed in the biomonitoring study, which identifiedCa, Cd and Pb, pH and electric conductivity (EC) as biomarkers of this cement plant. Vehicular trafficemissions and soil re-suspension could be observed in the biomonitors, giving a more complete scenario.In this study, biomonitoring studies along with the application of atmospheric dispersion models,allowed the atmospheric pollution to be assessed in more detail.Tillandsia capillaris Ruíz &amp; Pav. f. capillaris weretransplanted to the vicinities of the cement plant in order to determine the physiological damage andheavy metal accumulation (Ca, Mn, Fe, Co, Ni, Cu, Zn, Cd and Pb). For the application of the ISC3 model,point and area sources from the cement plant were considered to obtain average PM10 concentrationresults from the biomonitoring exposure period. This model permitted it to be determined that theemissions from the cement plant (point and area sources) were confined to the vicinities, without significantdispersion in the study area. This was also observed in the biomonitoring study, which identifiedCa, Cd and Pb, pH and electric conductivity (EC) as biomarkers of this cement plant. Vehicular trafficemissions and soil re-suspension could be observed in the biomonitors, giving a more complete scenario.In this study, biomonitoring studies along with the application of atmospheric dispersion models,allowed the atmospheric pollution to be assessed in more detail.10 concentrationresults from the biomonitoring exposure period. This model permitted it to be determined that theemissions from the cement plant (point and area sources) were confined to the vicinities, without significantdispersion in the study area. This was also observed in the biomonitoring study, which identifiedCa, Cd and Pb, pH and electric conductivity (EC) as biomarkers of this cement plant. Vehicular trafficemissions and soil re-suspension could be observed in the biomonitors, giving a more complete scenario.In this study, biomonitoring studies along with the application of atmospheric dispersion models,allowed the atmospheric pollution to be assessed in more detail.fined to the vicinities, without significantdispersion in the study area. This was also observed in the biomonitoring study, which identifiedCa, Cd and Pb, pH and electric conductivity (EC) as biomarkers of this cement plant. Vehicular trafficemissions and soil re-suspension could be observed in the biomonitors, giving a more complete scenario.In this study, biomonitoring studies along with the application of atmospheric dispersion models,allowed the atmospheric pollution to be assessed in more detail.fiedCa, Cd and Pb, pH and electric conductivity (EC) as biomarkers of this cement plant. Vehicular trafficemissions and soil re-suspension could be observed in the biomonitors, giving a more complete scenario.In this study, biomonitoring studies along with the application of atmospheric dispersion models,allowed the atmospheric pollution to be assessed in more detail.ficemissions and soil re-suspension could be observed in the biomonitors, giving a more complete scenario.In this study, biomonitoring studies along with the application of atmospheric dispersion models,allowed the atmospheric pollution to be assessed in more detail.","palabras_clave":"Tillandsia capillaris|Heavy metal enrichment factors|ISC3|Emission factor estimation technique"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38406,"idioma_id":5,"titulo":"Análisis comparativo de los patrones de modificaciones óseas de dos carnívoros sudamericanos: el gato montés (Leopardus geoffroyi) y el zorro pampeano (Lycalopex gymnocercus). Aportes para la identificación de la acción de pequeños carnívoros en el regist","resumen":"El objetivo de este  trabajo es caracterizar y comparar los patrones de modificaciones óseas  producidos por dos carnívoros autóctonos de Sudamérica, el zorro pampeano y el gato montés, sobre  partes esqueletarias de pequeños vertebrados. Para esto se realizó una  experiencia en un parque zoológico local, ofreciendo 10 conejos en forma  controlada, a cada uno de los predadores mencionados. En esta oportunidad se  presentan los resultados de los restos no ingeridos, para los cuales se analizó  la representación anatómica y los patrones de fractura. Los  resultados indican que tanto el gato montés como el zorro pampeano generan una  destrucción ósea significativa en los restos de conejo, lo cual impacta  directamente en la representación de los individuos. Los elementos con mayor  supervivencia fueron los huesos largos, la pelvis, el cráneo y la mandíbula. Por  otra parte, la densidad ósea resultó ser uno de los factores que condicionó la  destrucción diferencial de los elementos. Si bien nuestros resultados no  permiten diferenciar las modificaciones generadas por estas dos especies de  carnívoros, los patrones observados aportan nuevos datos que ayudan a  distinguir estos conjuntos de aquellos originados por otros predadores como por  ejemplo, aves rapaces diurnas y nocturnas.","palabras_clave":"TAFONOMÍA EXPERIMENTAL|GATO MONTÉS|ZORRO PAMPEANO|PEQUEÑOS VERTEBRADOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38407,"idioma_id":4,"titulo":"Lead accumulation in plants grown in polluted soils. Screening of native species for phytoremediation","resumen":"A field study was carried out in the vicinity of a former battery recycling plant, with heavy metal content (Pb and Zn), the toxicological risk of seed consumption of soybean crops [Glycine Max (L.) Merr.] grown on these soils and their relation with seed quality being evaluated. The concentrations of Pb and Zn in soybeans (roots, stems, pods and seeds) and in top soils were investigated and their potential risk to the health of consumers was estimated. Furthermore, quality related seed parameters (standard germination test, tetrazolium test, biomass and weight of 1000 seeds) were obtained. The results show that the concentrations of Pb in soybeans at all sites (controls and close to the smelter) were above the maximum permitted levels. Seed quality decreased as the lead concentration increased in seeds from sites near to the former battery recycling plant. Moreover, the greatest accumulation of Zn in seeds was found at sites with high concentrations of Pb in soils. Taking into account these findings future studies need to be performed in order to evaluate the parameters influencing the mobility and bioavailability of toxic metals in agricultural soils, with the purpose of not only assessing the current state of crops in terms of food security, but also to evaluate possible soil remediation techniques.","palabras_clave":"Lead polluted soils|Phytoextraction|Phytostabilization|Tagetes minuta|Bidens pilosa|Sorghum halepense"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38408,"idioma_id":4,"titulo":"Novel technique for ST-T interval characterization in patients with acute myocardial ischemia","resumen":"BACKGROUND  The novel signal processing techniques have allowed and improved the use of vectorcardiography (VCG) to diagnose and characterize myocardial ischemia. Herein, we studied vectorcardiographic dynamic changes of ventricular repolarization in 80 patients before(control) and during Percutaneous Transluminal Coronary Angioplasty (PTCA).    METHODS  We propose four vectorcardiographic ST-T parameters, i.e., (a) ST Vector Magnitude Area aSTVM); (b) T-wave Vector Magnitude Area (aTVM); (c) ST-T Vector Magnitude Difference ST-TVD), and (d) T-wave Vector Magnitude Difference (TVD). For comparison, the conventional ST-Change Vector Magnitude (STCVM) and Spatial Ventricular Gradient (SVG) were also calculated.    RESULTS  Our results indicate that several vectorcardiographic parameters show significant differences (pvalue<0.05) before starting and during PTCA. Statistical minute-by-minute PTCA comparison against the control situation showed that ischemic monitoring reached a Sensitivity = 90.5% and a Specificity = 92.6% at the 5th minute of the PTCA, when aSTVM and ST-TVD were used as classifiers.    CONCLUSIONS  We conclude that the sensitivity and specificity for acute ischemia monitoring could be increased with the use of only two vectorcardiographic parameters. Hence, the proposed technique based on vectorcardiography could be used in addition to the conventional ST-T  analysis for better monitoring of ischemic patients.","palabras_clave":"Ischemic Classifiers|Myocardial Ischemia|Percutaneous Transluminal Coronary Angioplasty|Vectorcardiography|ST-T Analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38409,"idioma_id":4,"titulo":"Source limitations due to leaf rust (Puccinia Triticina) during grain filling period in wheat","resumen":"Cereals crops are commonly characterized by source or sink limitations to grain yield determination. Different evidences haves shown that wheat crops that growth under no limitations are mainly sink-limited. Late foliar diseases (especially leaf rust) reduce the assimilates supply during post-anthesis, determining fewer assimilates per grain and thereby inducing grain weight reductions. Although the assimilates reduction hypothesis is the most accepted to explain decreases in grain weight reductions due to late foliar diseases, it has not been clearly established whether i) those reductions could be completely ascribed to source-limitations or ii) if  diminished in grain weight could be the consequence of reductions in grain weight potential. In this sense, leaf rust could reduce (i) grain weight potential (determining sink-limitations) and\/or (ii) achievable grain weight (determining source-limitations). The objective of this work was to determine if grain weight reductions due to leaf rust during grain filling period could be the consequenceassociated with of source-sink- limitations for growing wheat grains or the consequence of reductions oin grain weight potential. Two experiments (during 2007 and 2008 growing seasons) including healthy and diseased wheat crops were conducted under field conditions to fulfill the objective. Source-sink manipulation treatments and grain water content measurements were made to test the source- and sink- limitation hypothesis due to the appearance of late foliar diseases during the grain filling period. Leaf rust was induced to be appeared exclusively during the grain filling period and in both years it reduced grain yield and grain weight in both experiment. Grain yield reductions due to leaf rust were mainly associated with grain weight decreased. However, Aas an exception ofto distal grains, there were no significant differences between healthy and diseased plots oin maximum grain water content, indicating that late foliar diseases did not affect the potential size of the grains. The reserves stored in stems were remobilized to the growing grains in both, healthy and diseased crops. However, the reserves remaining at physiological maturity wereas significantly reduced in diseased crops. The reduction in grain number by trimming the spikes increased the grain weight in diseased but not in healthy crops. The grain weight of trimmed spikes in diseased crops reached similar values than into those of healthy crops. These results support   the hypothesis that foliar diseases could cause source-limitation for grain filling beyond differences ofin grain weight potential when the crops are severely affected by late foliar diseases as leaf rust.","palabras_clave":"Diseases|Wheat"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38410,"idioma_id":4,"titulo":"'Enhanced photodynamic leishmanicidal activity of a hydrophobic zinc phtalocyanine within archaeolipids-containing liposomes","resumen":"In this work, the in vitro anti-Leishmania activity of photodynamic liposomes made of soybean phosphatidylcholine, sodium cholate, total polar archaeolipids (TPAs) extracted from the hyperhalophile archaea Halorubrum tebenquichense and the photosensitizer zinc phthalocyanine (ZnPcAL) was compared to that of ultradeformable photodynamic liposomes lacking TPAs (ZnPcUDLs). We found that while ZnPcUDLs and ZnPcALs (130 nm mean diameter and &#8722;35 mV zeta potential) were innocuous against promastigotes, a low concentration (0.01 &#956;M ZnPc and 7.6 &#956;M phospholipids) of ZnPcALs irradiated at a very low-energy density (0.2 J\/cm2) eliminated L. braziliensis amastigotes from J774 macrophages, without reducing the viability of the host cells. In such conditions, ZnPcALs were harmless for J774 macrophages, HaCaT keratinocytes, and bone marrow-derived dendritic cells. Therefore, topical photodynamic treatment would not likely affect skin-associated lymphoid tissue. ZnPcALs were extensively captured by macrophages, but ZnPcUDLs were not, leading to 2.5-fold increased intracellular  delivery of ZnPc than with ZnPcUDLs. Despite mediating low levels of reactive oxygen species, the higher delivery of ZnPc and the multiple (caveolin- and clathrin-dependent plus phagocytic) intracellular pathway followed by ZnPc would have been the reason for the higher antiamastigote activity of ZnPcALs. The leishmanicidal activity of photodynamic liposomal ZnPc was improved by TPA-containing liposomes.","palabras_clave":"MACROPHAGES|LEISHMANIA AMASTIGOTES|ZN INTRACELLULAR DELIVERY|IRRADIATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38411,"idioma_id":4,"titulo":"Structural features of ultradeformable archaeosomes for topical delivery of ovalbumin","resumen":"The ultradeformable archaeosomes (UDA, made of total polar archaeolipids (TPA) extracted from the extreme halophile archaea Halorubrum tebenquichense:soybean phosphatidylcholine (SPC):sodium cholate (NaChol), 3:3:1 w:w), are promising topical adjuvants showing high deformability, an essential property for intact skin penetration up to the viable epidermis\/dermis. To gain insights on UDA structure, the interactions between TPA, SPC and the edge activator NaChol, were assessed by electrospray ionization mass spectroscopy (ESI-MS) and confocal fluorescence microscopy of giant unilamellar vesicles (GUV). The non covalent heterodimers NaChol?SPC, NaChol?phosphatidylglycerophosphate methyl ether (PGPMe), NaChol?sulfated diglycosyl diphytanyl?glycerol diether (SDGD5) and SPC?PGPMe detected in the gas phase by ESI-MS after direct infusion of UDA, together with the homogeneous partition of FASTDiO and DiIC18 in GUV suggested that in these proportions, lipids and NaChol were miscible. We propose therefore, a model where in UDA the SPC diluted sufficient enough in the rich PGPMe TPA, so as to the low lateral mobility of molecules (typical of rich in PGPMe bilayers) was no longer experienced. We also found that 50 &#956;m deep within in vitro human skin canyons, the fluorescence of Alexa fluor 647-ovalbumin in UDL was &#8764;1.5 folds higher than in UDA, indicating a potential steric hindrance of the voluminous structure of PGPMe UDA bilayer, to the penetration of a particulate cargo such as the 7 nm diameter ovalbumin. According to these observations, a further reduction in PGPMe ? a lipid playing no immune role ? content could help to improve the performance of UDA as topical adjuvants.","palabras_clave":"ULTRADEFORMABLE ARCHAEOSOMES|SKIN|PENETRATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38412,"idioma_id":4,"titulo":"Enhanced antimelanoma activity of methotrexate and zoledronic acid within polymeric sandwiches","resumen":"New therapies are urgently needed against melanoma, one of the most aggressive tumors.Melanoma cells are resistant to the antifolate methotrexate (MTX), since MTX is taken up by the folate receptor-alpha, sequestered in melanosomes and exported out of the cell. The bisphosphonate zoledronic acid (ZOL) is active in several non-skeletal tumors; however, its antitumoral activity is hampered by its long-term accumulation in bones and low cellular permeability. Recently, we showed than core-shell tecto-dendrimers made of amine-terminated polyamidoamine generation 5 dendrimer (G5) as core and carboxyl-terminated G2.5 dendrimer as shell (G5G2.5) had selective cytotoxicity to melanoma cells. We hypothesized here that the activity of MTX and ZOL on melanoma cells could be enhanced when loaded within G5G2.5.MTX and ZOL were loaded within G5 cores, which were covered by a covalently bound shell of G2.5 dendrimers (drug-sandwiches). 12 nm mean diameter and -12 mV Z potential drug-sandwiches incorporating 6 and 31 molecules of MTX and ZOL respectively, per G5G2.5, showed higher cytotoxicity (by MTT and apoptosis\/necrosis assays) to melanoma (Sk-Mel-28) cells than free drugs and G5G2.5. Only MTX-sandwich was cytotoxic to Sk-Mel-28 cells and harmless to keratinocytes (HaCaT cells). The intracellular pathway of G5G2.5 was followed using chemical inhibitors of endocytosis. The increased cytotoxicity of MTX-sandwich could be due to its uptake by macropinocytosis instead of by FR-alpha, avoiding MTX exocytosis. The increased cytotoxicity of ZOL-sandwich could be due to an increased intracellular accumulation of ZOL, owed by its endocytic uptake instead of diffusing as free drug.","palabras_clave":"MELANOMA|DENDRIMERS|ANTIFOLATES|BISPHOSPHONATES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38413,"idioma_id":4,"titulo":"Toll-like receptor activation and expression in bovine alpha-herpesvirus infections","resumen":"The involvement of Toll-like receptors (TLRs) in bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5)infections has not been analyzed. In this study, the role of TLR signaling on virus replication was investigated. Blood leukocytes consistently express TLRs. Thus, our approach was to study in vitro the effects of agonist stimulation of TLRs expressed by peripheral blood leukocytes on BoHV-1 and BoHV-5 replication.   Furthermore, the patterns of TLRs 3, 7?9 expression on virus-infected-bovine leukocytes were analyzed. Only Imiquimod (TLR7\/8 agonist) showed anti-viral activity on infected MDBK cells. This is the first evidence that the timely activation of TLR7\/8 signaling is effective in impairing BoHV-1 and 5 replication, thereby providing an experimental indication that Imiquimod may be a promising immune modulator.   This work describes, for the first time, the expression patterns of TLRs in BoHV-1- or BoHV-5-infected- bovine leukocytes, suggesting the involvement of TLR7 and TLR9 in the recognition of these viruses","palabras_clave":"Hepesvirus|Toll-Like-Receptor|Bovino"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38414,"idioma_id":4,"titulo":"The first caprine rotavirus detected in Argentina displays genomic features resembling virus strains infecting members of the Bovidae and Camelidae","resumen":"Rotavirus group A (RVA) is a major cause of diarrhea in humans and young animals including small ruminants. The purpose of this study was to identify RVA in dairy goat kids, and to characterize the complete genomic constellation and genetic relatedness with other RVA strains. Four out of twenty fecal samples from diarrheic and non-diarrheic goat kids were positive for RVA by ELISA. A representative sample was selected for further genome analyses. The RVA strain RVA\/Goat-wt\/ARG\/0040\/2011\/G8P[1] displayed the following genomic constellation: G8-P[1]-I2-R5-C2-M2-A3-N2-T6-E12-H3, reminiscent to guanaco and other bovine-like RVA strains detected in Argentina. Phylogenetic analyses revealed that most of the genome segments had a rather close relatedness with RVA strains typically obtained from cattle, sheep, South American camelids and goats. Interestingly, strain 0040 possessed the R5 and E12 genotypes which have up to date only been found in different animal species from Argentina. Overall, these findings suggest that strain 0040 could represent a typical goat RVA genome constellation similar to those previously found in other animal species within the order Artiodactyla.","palabras_clave":"Rotavirus  |Goat|G8P[1]|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38415,"idioma_id":4,"titulo":"Neospora caninum serostatus is affected by age and species variables in cohabiting water buffaloes and beef cattle","resumen":"The aim of this study was to investigate how Neospora caninum serostatus may be affectedby variables such as host species (water buffaloes or cattle) and age in animals cohabitingin the same ranch. A convenience cross-sectional study was performed on four ranches inthe Northeast of Argentina, where water buffalo are cohabitating with beef cattle. Bloodsamples were collected from 1350 female water buffaloes (Bubalus bubalis) and 880 femalebeef cattle (Bos taurus and Bos indicus crossbreeds) from four ranches. Calving and weaningpercentages at herd level for each ranch were also recorded. N. caninum antibody levelswere measured by an indirect fluorescent antibody test (IFAT) (reciprocal antibody titers¡Ý100). Serological results were classified into 2 categories (0: negative; 1: positive). A logis-tic regression model was used to describe the relationship between N. caninum serostatusand specie (water buffalo or cattle), age or ranch and their interactions. Likelihood ratiotests were used to assess the significance of the model and their terms. Odds ratios wereestimated and 95% profile likelihood (LR) and Wald confidence intervals (CI) obtained. Over-all, specific antibody titers were found in 43.3% (584\/1350) of water buffaloes and 28.6%(252\/880) of cattle. Seropositive water buffaloes and cattle were observed on all ranches.Age was statistically significant (p = 0.01) with an overall estimate of logit (log odds) of ageof 0.03 for both species. This indicates that for every one year increase in age, the expectedchange in log odds of being seropositive increased by 0.03. On three of four ranches a waterbuffalo was 4.48, 1.54 and 2.25 times more likely to be seropositive than cattle for animalsof the same age. The N. caninum serostatus was affected by age in the first place, but also byspecies on at least three of the four ranches. Calving and weaning percentages were higherin water buffaloes than in beef cattle (p < 0.05). Even though the low pathogenicity thatN. caninum seems to have in water buffaloes, this study reinforces the importance of thisspecie as maintenance of the disease.","palabras_clave":"Beef cattle|Neospora caninum|Water buffalo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38416,"idioma_id":4,"titulo":"Sandy rivers: a review on general ecohydrological patterns of benthic invertebrate assemblages across continents","resumen":"The middle and lower sections of most large rivers have fine-grained bed sediments, which may have a strong influence on the functional and taxonomical structure of benthic invertebrates. Based on results from several studies by the authors on the faunal assemblages and habitat structures of the Paraguay-Paraná River system (Brazil, Paraguay, Argentina), from European (Rhine, Loire) River systems, and data from the literature, this review identifies general patterns which appear to have a global character. At one hand the invertebrate assemblages largely differed between main channel and the corresponding floodplain habitats in different sections, and also the floodplain habitats along the river channel revealed great differences in their biodiversity. At the other hand there was a remarkable homogeneity among the main-channel sections within and even between river systems.We consider physical habitat features as the crucial variable responsible for these patterns. In crosssections from the main channel towards the floodplain habitats, grain size, organic matter content and oxygen supply change dramatically, and different floodplain habitats along the same river system may have different successional stages even at small geographical distances. The sandy structure of potamal habitats (including underwater dunes), however, provides a set of habitat features characterized by continuously changing sediment structures with well-defined grain sizes, low organic matter contents, and good oxygenation, which force a set of adaptations by the invertebrates that limits but stabilizes the diversity of invertebrates in these large river sections. A better understanding of the ecohydrological interactions between habitat dynamics and benthic invertebrates is needed to improve sustainable river ecosystem management. We discuss the non recovery of large benthic invertebrate species in the lower section of large rivers after improvement of the water quality in the context of these ecohydrological features. Conclusions are drawn for river restoration.","palabras_clave":"Benthic invertebrate assemblages|Underwater sand dunes|Paraguay River|Paraná River|Loire River|Ecohydraulics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38417,"idioma_id":4,"titulo":"Reformulating the TBA equations for the quark anti-quark potential and their two loop expansion","resumen":"The boundary thermodynamic Bethe Ansatz (BTBA) equations introduced<br in [1, 2] to describe the cusp anomalous dimension contain imaginary chemical potentials and singular boundary fugacities, which make its systematic expansion problematic. We propose an alternative formulation based on real chemical potentials and additional source terms. We expand our equations to double wrapping order and find complete agreement with the direct two-loop gauge theory computation of the cusp anomalous dimension.","palabras_clave":"AdS-CFT correspondence|Integrable field theories"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38418,"idioma_id":4,"titulo":"Development of reduced fat minced meats using inulin and bovine  plasma proteins as fat replacers","resumen":"This work deals with the effect of the addition of inulin and bovine plasma proteins as fat replacers, on the quality of minced meat. The proteins are obtained by ultrafiltration and freeze-drying.  The following determinations were carried out: chemical composition, sensorial analysis (color, flavor, taste and consistency), emulsion stability and instrumental texture analysis of samples. The resulting formulations were compared with full-fat minced meat, as control. The results showed an increase of protein contents after fat replacement, while a fat reduction of 20-35% produced light products enriched with proteins and inulin as the functional ingredient.  No change was observed in color, flavor, or taste among the samples. However, the sensory analysis showed that the combination of plasma protein (2.5 %w\/w) and inulin (2 %w\/w) had the best acceptability with respect to consistency, and had a lower fat drain from the emulsion. Texture profile analysis revealed that this formulation assimilated the control texture properties, being this result required for adequate consumer acceptance.","palabras_clave":"minced meat|fat replacers|bovine plasma proteina|texture profile anlisys"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38419,"idioma_id":4,"titulo":"Each flying fox on its own branch: A phylogenetic tree for Pteropus and related genera (Chiroptera: Pteropodidae)","resumen":"Pteropodidae is a diverse Old World family of non-echolocating, frugivorous and nectarivorous bats thatincludes the flying foxes (genus Pteropus) and allied genera. The subfamily Pteropodinae includes thelargest living bats and is distributed across an immense geographic range from islands in East Africa tothe Cook Islands of Polynesia. These bats are keystone species in their ecosystems and some carry zoonoticdiseases that are increasingly a focus of interest in biomedical research. Here we present a comprehensivephylogeny for pteropodines focused on Pteropus. The analyses included 50 of the 63 species ofPteropus and 11 species from 7 related genera. We obtained sequences of the cytochrome b and the 12SrRNA mitochondrial genes for all species and sequences of the nuclear RAG1, vWF, and BRCA1 genes for asubsample of taxa. Some of the sequences of Pteropus were obtained from skin biopsies of museum specimensincluding that of an extinct species, P. tokudae. The resulting trees recovered Pteropus as monophyletic,although further work is needed to determine whether P. personatus belongs in the genus.Monophyly of the majority of traditionally-recognized Pteropus species groups was rejected, but statisticalsupport was strong for several clades on which we based a new classification of the Pteropus speciesinto 13 species groups. Other noteworthy results emerged regarding species status of several problematictaxa, including recognition of P. capistratus and P. ennisae as distinct species, paraphyly of the P. hypomelanuscomplex, and conspecific status of P. pelewensis pelewensis and P. p. yapensis. Relationships amongthe pteropodine genera were not completely resolved with the current dataset. Divergence time analysissuggests that Pteropus originated in the Miocene and that two independent bursts of diversificationoccurred in the Pleistocene in different regions of the Indo-Pacific realm.","palabras_clave":"pteropus|pteropodidae|chiroptera|Sequencing of museum specimens|island taxa|molecular phylogeny"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38420,"idioma_id":4,"titulo":"Tailoring Optical Fields Emitted by Subwavelength Nanometric Sources","resumen":"In this work, we study a simple way of controlling the emitted fields of subwavelength nanometric sources. The system studied consists of arrays of nanoparticles (NPs) embedded in optical active media. The key concept is the careful tuning of NP?s damping factors, which changes the eigenmode?s decay rates of the whole array. This inevitably leads, at long time, to a locking of relative phases and frequencies of individual localized-surfaces-plasmons (LSPs) and, thus, controls the emitted field. The amplitude of the LSP?s oscillations can be kept constant by embedding the system in optical active media. In the case of full loss compensation, this implies that not only the relative phases, but also the amplitudes of the LSPs remain fixed, leading us, additionally, to interpret the process as a new example of synchronization. The proposed approach can be used as a general way of controlling and designing the electromagnetic fields emitted by nanometric sources, which can find applications in optoelectronic, nanoscale lithography, and probing microscopy.","palabras_clave":"Plasmonics |Localized-surface-plasmons|Active medium|· Synchronization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38421,"idioma_id":4,"titulo":"Landau-Zener and Rabi oscillations in the spin-dependent conductance","resumen":"We describe the spin-dependent quantum conductance in a wire where a   magnetic field is spatially modulated. The changes in direction and   intensity of the magnetic field acts as a perturbation that mixes spin   projections. This is exemplified by a ferromagnetic nanowire. There the   local field varies smoothly its direction generating a domain wall (DW)   as described by the well known Cabrera-Falicov model. Here, we   generalize this model to include also a strength modulation. We identify   two striking diabatic regimes that appear when such magnetic   inhogeneity occurs. 1) If the field strength at the DW is weak enough   the local Zeeman energies result in an avoided crossing. Thus, the spin   flip probability follows the Landau-Zener formula. 2) For strong fields,   the spin-dependent conductance shows oscillations as function of the DW   width. We interpret them in terms of Rabi oscillations. Time and length   scales obtained from this simplified view show an excellent agreement   with the exact dynamical solution of the spin-dependent transport. These   results remain","palabras_clave":"Spin polarized transport|Magnetoelectronics|spintronics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38422,"idioma_id":4,"titulo":"Physiological and biochemical characterization of  Azospirillum brasilense strains commonly used as plant  growth-promoting rhizobacteria","resumen":"Azospirillum is a plant growth-promoting rhizobacteria (PGPR) genus vastly studied and utilized as agriculture inoculants. Isolation of new strains under different environmental conditions allows the access to the genetic diversity and improves the success of inoculation procedures. Historically, the isolation of this genus has been performed by the use of some traditional culture media. In this work we characterized the physiology and biochemistry of five different A. brasilense strains, commonly used as cereal inoculants. The aim of this work is to contribute to pose into revision some concepts concerning the most used protocols to isolate and characterize this bacterium. We characterized their growth in different traditional and non-traditional culture media, evaluated some PGPR mechanisms and characterized their profiles of fatty acid methyl esters and carbon-source utilization. This work shows, for the first time, differences in both profiles, and ACC deaminase activity of A. brasilense strains. Also, we show unexpected results obtained in some of the evaluated culture media. Results obtained here and an exhaustive knowledge revision revealed that it is not appropriate to conclude about bacterial species without analyzing several strains. Also, it is necessary to continue developing studies and laboratory techniques to improve the isolation and characterization protocols.","palabras_clave":"agriculture sustainability|biological nitrogen fixation|fatty acid methyl esters analysis|plant growth promotion mechanisms|physiological profiles"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38423,"idioma_id":4,"titulo":"The Chloroplast Genome of Hyoscyamus niger and a Phylogenetic Study of the Tribe Hyoscyameae (Solanaceae)","resumen":"The tribe Hyoscyameae (Solanaceae) is restricted to Eurasia and includes the genera Archihyoscyamus, Anisodus, Atropa, Atropanthe, Hyoscyamus, Physochlaina, Przewalskia and Scopolia. Even though the monophyly of Hyoscyameae is strongly supported, the relationships of the taxa within the tribe remain unclear. Chloroplast markers have been widely used to elucidate plant relationships at low taxonomic levels. Identification of variable chloroplast intergenic regions has been developed based on comparative genomics of chloroplast genomes, but these regions have a narrow phylogenetic utility. In this study, we present the chloroplast genome sequence of Hyoscyamus niger and make comparisons to other solanaceous plastid genomes in terms of gene order, gene and intron content, editing sites, origins of replication, repeats, and hypothetical open reading frames. We developed and sequenced three variable plastid markers from eight species to elucidate relationships within the tribe Hyoscyameae. The presence of a horizontally transferred intron in the mitochondrial cox1 gene of some species of the tribe is considered here a likely synapomorphy uniting five genera of the Hyoscyameae. Alternatively, the cox1 intron could be a homoplasious character acquired twice within the tribe. A homoplasious inversion in the intergenic plastid spacer trnC-psbM was recognized as a source of bias and removed from the data set used in the phylogenetic analyses. Almost 12 kb of plastid sequence data were not sufficient to completely resolve relationships among genera of Hyoscyameae but some clades were identified. Two alternative hypotheses of the evolution of the genera within the tribe are proposed.","palabras_clave":"CHLOROPLAST|HYOSCYAMEAE|HYOSCYAMUS NIGER|PHYLOGENY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38424,"idioma_id":4,"titulo":"Increased migration of human mesenchymal stromal cells by autocrine motility factor (AMF) resulted in enhanced recruitment towards hepatocellular carcinoma","resumen":"BACKGROUND AND AIMS:Several reports described the migration of human mesenchymal stromal cells (MSCs) towards tumor-released factors. Autocrine motility factor (AMF) is produced by several tumors including hepatocellular carcinoma (HCC). The aim of this study was to analyze AMF involvement on MSC migration towards human HCC. METHODS: Production of AMF by HCC tumors was evaluated by western analysis. The effects of AMF on MSCs from different sources (bone marrow, adipose tissue and perivascular cells from umbilical cord) were analyzed using in vitro migration assay; metalloproteinase 2 (MMP2) activity and expression of critical genes were studied by zymography and qRT-PCR, respectively. To assess AMF involvement on the in vivo MSC migration, noninvasive fluorescence imaging was performed. To test the effect of AMF-primed MSCs on tumor development, in vitro proliferation and spheroids growth and in vivo tumor volume were evaluated.RESULTS: AMF produced by HCC was found to induce migration of different MSCs in vitro and to enhance their MMP2 activity. Stimulation of MSCs with recombinant AMF (rAMF) also induced the in vitro adhesion to endothelial cells in coincidence with changes in the expression levels of MMP3, AMF receptor, caveolin-1, and -2 and GDI-2. Importantly, stimulation of MSCs with rAMF increased the in vivo migration of MSCs towards experimental HCC tumors. AMF-priming of MSCs did not induce a pro-tumorigenic effect on HCC cells neither in vivo nor in vitro. CONCLUSION: AMF plays a role in MSC recruitment towards HCC. However, its ability to increase MSC migration to HCC for therapeutic purposes merits further evaluation.","palabras_clave":"Migration|Mesenchymal Stromal Cells|Autocrine Motility Factor|Hepatocellular Carcinoma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38425,"idioma_id":4,"titulo":"Differential toxicity and uptake of Diazinon on embryo-larval development of Rhinella arenarum","resumen":"Diazinon is an organophosphate extensively used pesticide. The main objective of this work was to assess the lethal and sublethal effects of Diazinon and its correlation with the uptake by embryos and larvae of the common South American toad Rhinella arenarum by means of standardized bioassays during acute (96 h), short-term chronic (168 h) and chronic (504 h) exposures. Toxicity resulted time- and stage-dependent, thus the Lethal Concentration 50 for acute, short-term chronic and chronic exposure were 27.2; 20.1 and 6.8mg Diazinon\/L for embryos and 8, 6.7 and 1.9 mg Diazinon\/L for larvae. It is noteworthy the remarkable differences found in the concentration which caused lethality with those causing teratogenic effects. Therefore, the Teratogenic Index from 144 h was greater than two; the main adverse effects were axial flexures, irregular borders, wavy tail, microcephaly, malformed mouth and adhesive structures, gut miscoiling, underdeveloped gills, cloacal edema, desquamation and severe hydropsy. Moreover, the characteristic sublethal effect of Diazinon on larvae was abnormal behaviour related to neurotoxicity with a NOEC-168 h of 4.5 mg Diazinon\/L. Uptake of Diazinon was time-dependent and significantly related to exposure concentration for both embryos and larvae. Uptake was also stage-dependent, as it was up to 27 times higher for organisms exposed from blastula stage onwards than early larvae. These facts and the Hazard Quotients of 2.73, which is above USEPA´s Level of Concern, showed the threat that Diazinon represents for R. arenarum populations.","palabras_clave":"Amphibian embryo-larval development|Differential toxicity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38426,"idioma_id":4,"titulo":"Zooplankton and their driving factors in a large subtropical river during low water periods","resumen":"The composition, abundance and functional diversity of zooplankton from the main channel of the Middle Paraná River were studied. Monthly samples were collected in both ordinary drought periods (1977, 1978, 1981, 2007) and extraordinary drought ones (La Niña events 1971?1972, 1999?2000). A constant pattern of zooplankton structure was recorded from 1971 to 1981 characterised by a strong rotifer dominance. Changes were observed in the last two periods, with the planktonic larvae of Limnoperna fortunei as a new component of zooplankton. The abundance of zooplankton showed a significant interannual variability and a decreasing trend over time with the maximum values almost 100 times lower from 1999 onwards, mainly resulting from a decline in rotifer density. Cladocerans and copepods occurred with very low abundance and were similar across years. Bosmina and Bosminopsis showed a decreasing trend through time. Evidence was found of intrazooplanktonic competition between rotifers and cladocerans. Zooplankton and phytoplankton abundance presented similar trends, but the edible algal fraction (< 20 &#956;m) showed a negative relation with Bosminidae, suggesting cladoceran control. In the last period, zooplankton changes were not associated with physical parameters (except flow velocity), nutrients or phytoplankton. The absence of a constant pattern and the causes of the declining trend of zooplankton abundance over time could be related to biotic interactions and multiple-stressors throughout the study.","palabras_clave":"LONG-TERM STUDY|MICROPHAGOUS ROTIFERS|PHYTOPLANKTON|SELECTIVE FILTER FEEDING CLADOCERANS|ZOOPLANKTON ABUNDANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38427,"idioma_id":4,"titulo":"Characterization of a Mycobacterium avium subsp. avium Operon \tAssociated with Virulence and Drug Detoxification","resumen":"      The lprG-p55 operon of Mycobacterium  tuberculosis and Mycobacterium bovis is involved in the transport of toxic  compounds. P55 is an efflux pump that provides resistance to several drugs,  while LprG is a lipoprotein that modulates the host?s immune response  againstmycobacteria.The knock out mutation of this operon severely reduces the  replication of both mycobacterial species during infection in mice and  increases susceptibility to toxic compounds. In order to gain insight into the  function of LprG in the Mycobacterium avium complex, in this study, we assayed  the effect of the deletion of lprG gene in the D4ER strain of Mycobacterium avium  subsp.avium. The replacement of lprG gene with a hygromycin cassette caused a  polar effect on the expression ofp55. Also,a two fold decrease in ethidium  bromide susceptibility was observed and the resistance to the antibiotics  rifampicin, amikacin, linezolid, and rifabutin was impaired in the mutant  strain. In addition, the mutation decreased the virulence of the bacteria in macrophages  in vitro and in a mice model in vivo. These findings clearly indicate that  functional LprG and P55 are necessary for the correct transport of toxic  compounds and for the survival of MAA in vitro and in vivo.  ","palabras_clave":"LPRG|MYCOBACTERIUM|MUTANT|VIRULENCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38428,"idioma_id":4,"titulo":"Electrophysiological and behavioural response of Aedes albopictus to n- heinecosane, an ovipositional pheromone of Aedes aegypti.","resumen":"  Aedes aegypti (L.) and Aedes albopictus (Skuse) (Diptera: Culicidae) are highly anthropophilic mosquitospecies and potential vectors of dengue and yellow fever. The location of suitable sites for ovipositionrequires a set of visual, tactile, and olfactory cues that influence females before they lay theireggs. In this study, the effect of n-heneicosane, a recognized oviposition pheromone of Ae. aegypti, onthe olfactory receptors of the antennae of Ae. aegypti and Ae. albopictus was studied using electroantennographicdetection coupled to gas chromatography (GC-EAD). A significant electroantennographicresponse to n-heneicosane in adult females of both mosquito species was observed. Inaddition, gravid Ae. albopictus females laid more eggs in substrate treated with n-heneicosane at 0.1, 1,or 10 p.p.m. than in the control, denoting oviposition attractancy. Conversely, at 30, 50, 100, and200 p.p.m., more eggs were laid in the control substrate, indicating oviposition repellency. Analysis ofthe larval cuticle by GC andmass spectrometry confirmed the presence of n-heneicosane in the cuticlesof Ae. albopictus larvae. The species-specific role of n-heneicosane as an oviposition pheromone inAe. aegypti and its significance as a behaviourmodifier of Ae. albopictus in breeding sites is discussed.  ","palabras_clave":"heneicosane|aedes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38429,"idioma_id":4,"titulo":"Volatile Organic Compounds from the Clone Populus x canadensis ??Conti?? Associated with Megaplatypus mutatus Attack","resumen":"Megaplatypus mutatus (=Platypusmutatus) (Chapuis) (Coleoptera: Platypodidae) is an ambrosia beetlenative to South America. The galleries these beetlesbore in tree trunks weakens them, causing severe stem-breakage and mortality incommercial poplar plantations. Pioneer males select ahost tree and initiate their attack building a short nuptial gallery, fromwhere they attract females using a sexual pheromone. The preference of attackfor M. mutatus has been correlated with anincreasing trunk diameter. Here we study the possibility that the differentialsusceptibility of individual plants could be associated with the volatiles theyrelease. We collected, analyzed and identified volatiles emitted by thewood-bark of attacked and non-attacked plants during the M. mutatusflight season. The volatile profiles of attacked and non-attacked trees showedqualitative and quantitative differences. The following compounds were observedin volatiles from the attacked plants: a long chain aldehyde of rt:20.57,&#945;-ylangene, &#948;-cadinene, &#945;-gurjunene and &#946;-cubebene. On the other hand,&#946;-sesquiphelandrene and &#946;-chamigrene were detected in volatiles from non-attackedplants but not in attacked ones. The results showed that &#945;-copaene is a commoncomponent in all the samples analyzed, although its relative concentration isincreased in attacked individuals. We also tested the biological activity of identifiedcompounds in the volatile emissions with a walking behavioral assay. Behavioralbioassays showed that M. mutatusmales are attracted to &#945;-copaene, but not the females. The relative increase of&#945;-copaene in attacked individuals and the positive behavioral answer of malesuggests that this compound might play a role in the orientation of the pioneermale towards the most suitable host.  ","palabras_clave":"poplar|ambrosia beetle|host"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38430,"idioma_id":4,"titulo":"Courtyards as a passive strategy in semi dry areas. Assessment of summer energy and thermal conditions in a refurbished school building","resumen":"This paper presents the results of applying an experimental and theoretical model for the assessment of courtyards as a passive strategy for interior space conditioning. Two representative case studies, in a refurbished pre-elementary school building in Mendoza, Argentina, were selected for the analysis. The summer thermal behaviour was analysed through HOBO H8-003-02 data loggers installed in two courtyards and in the adjacent classrooms. The record included weather data every 15 minutes for 40 summer days. Finally, a dynamic simulation of the two case studies and theoretical cases was carried out. The objective was to assess the impact of different open space design variables on the energy consumption necessary for obtaining comfort conditions in the interior space (base temperature: 25ºC). Overall results indicate that, in semi dry areas with a large number of clear sky days, the shade condition of the courtyard is the strategy that most highly impacts the thermal and energy conditions in classrooms.","palabras_clave":"COURTYARDS|INTERIOR SPACES|THERMAL AND ENERGY CONDITIONS|DRY AREAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38431,"idioma_id":4,"titulo":"Spreading the clinical window for diagnosing fetal-onset hypogonadism in boys","resumen":"In early fetal development, the testis secretes ? independent of pituitary gonadotropins ?androgens and anti-Müllerian hormone (AMH) that are essential for male sex differentiation.  In the second half of fetal life, the hypothalamic?pituitary axis gains control of testicular hormone secretion. Follicle-stimulating hormone (FSH) controls Sertoli cell proliferation,responsible for testis volume increase and AMH and inhibin B secretion, whereas luteinizing hormone (LH) regulates Leydig cell androgen and INSL3 secretion, involved in the  growth and trophism of male external genitalia and in testis descent.This differential regulation of testicular function between early and late fetal periods underlies the distinct clinical presentations of fetal-onset hypogonadism in the newborn male: primary hypogonadism results in ambiguous or female genitalia when early fetal-onset, whereas it becomes clinically undistinguishable from central hypogonadism when established later in fetal life. The assessment of the hypothalamic?pituitary?gonadal axis in male has classically relied on the measurement of gonadotropin and testosterone levels in serum. These hormone levels normally decline 3?6 months after birth, thus constraining the clinical evaluation window  for diagnosing male hypogonadism. The advent of new markers of gonadal function has spread this clinical window beyond the first 6 months of life. In this review, we discuss the advantages and limitations of old and new markers used for the functional assessment of the hypothalamic?pituitary?testicular axis in boys suspected of fetal-onset hypogonadism","palabras_clave":"hypopituitarism|cryptorchidism|micropenis|testosterone"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38432,"idioma_id":5,"titulo":"GENESIS DE UNA UNIDAD DE OPTIMIZACION DE LA FARMACOTERAPIA EN ARGENTINA.","resumen":"Los medicamentos colaboraron en cimentar mayor salud, sin  embargo son generadores de problemas que surgen de no atender adecuadamente la  complejidad farmacoterapéutica. En este sentido, resulta propicio incorporar el  concepto de Atención Farmacéutica (AF) para repensar la actuación de los  farmacéuticos. La implementación de AF muestra un impacto positivo en  resultados clínicos, humanísticos y económicos, pero se reconocen barreras para  su implementación. El sistema de salud argentino es fragmentado y los servicios  farmacéuticos se encuentran incluidos en esta lógica. En este contexto, la  Universidad y el Colegio de Farmacéuticos observan la necesidad de conformar  espacios de AF. El objetivo de esta comunicación es presentar la génesis de la  Unidad de Optimización de la Farmacoterapia (UOF) como un servicio a la  población en la ciudad de Rosario, Argentina. La UOF integra actividades de  asistencia, docencia e investigación e intenta promover aproximación entre la  Universidad Pública y la comunidad en relación a la problemática de utilización  de medicamentos. Funciona desde abril de 2012 y se entiende como alternativa de  inclusión social, disponible gratuitamente, con criterios bioéticos que  alcancen tanto a la relación profesional-paciente, al diseño de políticas de  medicamentos como a la evaluación económica y desarrollo de herramientas  metodológicas y tecnológicas","palabras_clave":"medicamentos |atención farmacéutica |universidad|población"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38433,"idioma_id":4,"titulo":"A reappraisal of Notohypshilophodon comodorensis (Ornithischia: Ornithopoda) from the Late Cretaceous of Patagonia, Argentina","resumen":"The Bajo Barreal Formation (Cenomanian, Late Cretaceous; central Patagonia, Argentina) preserves an important and rich fossil record. Among the dinosaurs described, a small ornithischian, Notohypsilophon comodorensis, was named in the 1990s. This small-bodied dinosaur, the most complete representative of the group discovered in that formation, was described as a ?hypsilophodontid ornithopod based on close morphological affinities with other members of that group,which is currently regarded as paraphyletic. Within this context, we present a restudy of Notohypsilophodon. This dinosaur is considered a basal ornithopod, probably more basal than Gasparinisaura. Likewise, this analysis emends and provides additional unique anatomical characters that support its taxonomic validity and position. On the basis of weak evidence, Notohypsilophodon might share the presence of gastroliths with other basal ornithopods (Gasparinisaura and Haya), which could suggest a specific behavior in response to its food ingestion. Finally, this study increases our knowledge of the evolutionary dynamics of South American Cretaceous ornithopods, and therefore broadens our knowledge of the early Late Cretaceous continental vertebrate assemblages of central Patagonia and of the Southern Hemisphere in general.","palabras_clave":"Ornithischia|Ornithopoda |Late Cretaceous|Bajo Barreal Formation|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38434,"idioma_id":4,"titulo":"Thermal expansion recovery microscopy. Practical design considerations","resumen":"A detailed study of relevant parameters for the design and operation of a photothermal microscope  technique recently introduced is presented. The technique, named thermal expansion recovery microscopy  (ThERM) relies in the measurement of the defocusing introduced by a surface that expands  and recovers upon the heating from a modulated source. A new two lens design is presented that  can be easily adapted to commercial infinite conjugate microscopes and the sensitivity to misalignment  is analyzed. The way to determine the beam size by means of a focus scan and the use of that  same scan to verify if a thermoreflectance signal is overlapping with the desired ThERM mechanism  are discussed. Finally, a method to cancel the thermoreflectance signal by an adequate choice of a  nanometric coating is presented.","palabras_clave":"MICROSCOPIA|FOTOTERMICA|COMBUSTIBLES NUCLEARES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38435,"idioma_id":4,"titulo":"Arabidopsis thaliana Embryo Sac Mitochondrial Membrane Potential Stain","resumen":"The aim of this experiment is to study mitochondrial functional status in Arabidopsis embryo sacs using the membrane potential indicator JC-1. Changes in the membrane potential are presumed to be due to the opening of the mitochondrial permeability transition pore (MPTP), allowing passage of ions and small molecules. The resulting equilibrium of ions leads in turn to the decoupling of the respiratory chain and the release of cytochrome c into the cytosol, a distinctive feature of the early stages of programmed cell death.JC-1 is a lipophilic dye that can selectively enter into mitochondria and reversibly change color from green to red as the membrane potential increases. In healthy cells with high mitochondrial potential, JC-1 spontaneously forms complexes with intense red fluorescence. On the other hand, in mitochondria with low mitochondrial potential, JC-1 remains in the monomeric form, which exhibits only green fluorescence (Martin et al., 2013; Hauser et al., 2006).This protocol could be used in isolated mitochondria, and in a variety of cell types and different tissues of plants and other organism.","palabras_clave":"embryo sac|Arabidopsis|mitochondria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38436,"idioma_id":4,"titulo":"Modeling of the dielectric properties of trabecular bone samples at microwave frequency","resumen":"In this paper, the dielectric properties of human trabecular bone are evaluated under physiological condition in the microwave range. Assuming a two components medium, simulation and experimental data are presented and discussed. A special experimental setup is developed in order to deal with inhomogeneous samples. Simulation data are obtained using finite difference time domain from a realistic sample. The bone mineral density of the samples are also measured. The simulation and experimental results of the present study suggest that there is a negative relation between bone volume fraction (BV\/TV) and permittivity\/conductivity: the higher the BV\/TV, the lower the permittivity\/conductivity. This is in agreement with the recently published in vivo data.","palabras_clave":"Bone dielectric properties| Microwave tomography"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38437,"idioma_id":4,"titulo":"Surface chemistry of thiomalic acid adsorption on planar gold and gold nanoparticles","resumen":"The self-assembly of thiomalic acid (TMA) on Au(111) and on preformed Au nanoparticles (AuNPs) protected by weak ligands has been studied by X-ray photoelectron spectroscopy (XPS) and electrochemical techniques. Results show that TMA is adsorbed on the Au(111) surface as thiolate species with a small amount of atomic sulfur (~10%), and a surface coverage lower to that found for alkanethiols due to steric factors. The amount of atomic sulfur markedly increases when the TMA is adsorbed on AuNPs by the ligand exchange method. We propose that the atomic sulfur is produced as a consequence of C-S bond cleavage, a process that is more favorable at defective sites of the AuNPs surface. The bond scission is also assisted by the presence of the electron-withdrawing carboxy moiety in alpha position relative to the C-S bond. Moreover, the high local concentration of positive charged species increases the stability of the negatively charged leaving group, leading to a higher amount of coadsorbed atomic sulfur. Our results demonstrate that the terminal functionalities of thiols are conditioning factors in the final structure and composition of the adlayers.","palabras_clave":"THIOMALIC ACID|Au NANOPARTICLES|THIOLATE|SULFIDE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38438,"idioma_id":4,"titulo":"Final state of a perturbed liquid film inside a container under the effect of solid-liquid molecular forces and gravity","resumen":"We investigate theoretically the possible final stationary configurations that can be reached by a laterallyconfined uniform liquid film inside a container. The liquid is under the action of gravity, surface tension, andthe molecular interaction with the solid substrate. We study the case when the container is in an upright positionas well as when it is turned upside down. The governing parameters of the problem are the initial thicknessof the film, the size of the recipient that contains the liquid, and a dimensionless number that quantifies therelative strength of gravity with respect to the molecular interaction. The uniform film is always a possible finalstate and depending on the value of the parameters, up to three different additional final states may exist, eachone consisting in a droplet surrounded by a thin film. We derive analytical expressions for the energy of thesepossible final configurations and from these we analyze which state is indeed reached. A uniform thin film mayshow three different behaviors after a perturbation: The system recovers its initial shape after any perturbation,the fluid evolves towards a drop (if more than one is possible, it tends toward that with the thinnest precursorfilm) for any perturbation, or the system ends as a uniform film or a drop depending on the details of theperturbation.","palabras_clave":"DROPLETS|THIN FILMS|DISJOINING PRESSURE|MOLECULAR FORCES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38439,"idioma_id":4,"titulo":"2D-ice templated titanium oxide films as advanced conducting platforms for electrical stimulation","resumen":"Directional freezing has been widely employed to prepare highly ordered three-dimensional (3D) porous  assemblies. However, in this scenario, there is one concept that has not been extensively explored: by  applying directional freezing to a nanoparticle (NP) dispersion supported on a substrate, twodimensionally  (2D) patterned films may be produced. In this study, tunable 2D-patterning of TiO2-NP  dispersions on alumina substrates is demonstrated. By imposing different temperature gradients  throughout the ceramic dispersion coatings, both homogeneous (non-patterned) and highly aligned  patterned topologies (consisting of parallel grooves) were produced. In the case of patterned films, the  orientation of the grooves was modulated from those oriented along the freezing direction to those  perpendicularly oriented to the temperature gradient. Thermally induced reduction of the prepared films  led to electrically conducting titanium oxide Magn´eli phases. The measured resistances were strongly  dependent on the orientation of the aligned patterns. To demonstrate the possibility of employing these  structured films as platforms for electrical stimulation-related applications, a stimulating electronic circuit  was developed and connected to the prepared films. Charge-balanced biphasic stimulus pulses with  tunable current amplitudes and frequencies were successfully delivered through the conducting 2Dpatterned  assemblies.","palabras_clave":"TITANIUM OXIDE|CONDUCTING PLATFORMS|ELECTRICAL STIMULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38440,"idioma_id":4,"titulo":"Ficus carica L. (Moraceae): an ancient source of food and health","resumen":"Since early in the man history, common fig was appreciated as food and for its medicinal   properties. This review explores some aspects about the importance of Ficus carica L., an amazing and   ancient source of medicines and food. Topics regarding chemistry, biological activity, ethnopharmacological uses, and its nutritional value are discussed, as well as the potential of the species as a   source of new and different chemical scaffolds. Very important in the past, appreciated in our time and   extremely promising in the future, F. carica represents an interesting example of healthy foods and   bioproducts.","palabras_clave":"FICUS CARICA|ETHNOPHARMACOLOGY|ENDOPHYTIC FUNGI|LATEX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38441,"idioma_id":4,"titulo":"Expression of codon optimized genes in microbial systems: current industrial applications and perspectives","resumen":"The efficient production of functional proteins in heterologous hosts is one of the major bases of modern biotechnology. Unfortunately, many genes are difficult to express outside their original context. Due to their apparent ?silent? nature, synonymous codon substitutions have long been thought to be trivial. In recent years, this dogma has been refuted by evidence that codon replacement can have a significant impact on gene expression levels and protein folding. In the past decade, considerable advances in the speed and cost of gene synthesis have facilitated the complete redesign of entire gene sequences, dramatically improving the likelihood of high protein expression. This technology significantly impacts the economic feasibility of microbial-based biotechnological processes by, for example, increasing the volumetric productivities of recombinant proteins or facilitating the redesign of novel biosynthetic routes for the production of metabolites. This review discusses the current applications of this technology, particularly those regarding the production of small molecules and industrially relevant recombinant enzymes. Suggestions for future research and potential uses are provided as well.","palabras_clave":"SYNTHETIC BIOLOGY|GENE DESIGN|CODON OPTIMIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38442,"idioma_id":4,"titulo":"The Alternative Role of Enterobactin as an Oxidative Stress Protector Allows Escherichia coli Colony Development","resumen":"Numerous bacteria have evolved different iron uptake systems with the ability to make use of their own and heterologous siderophores. However, there is growing evidence attributing alternative roles for siderophores that might explain the potential adaptive advantages of microorganisms having multiple siderophore systems. In this work, we show the requirement of the siderophore enterobactin for Escherichia coli colony development in minimal media. We observed that a strain impaired in enterobactin production (entE mutant) was unable to form colonies on M9 agar medium meanwhile its growth was normal on LB agar medium. Given that, neither iron nor citrate supplementation restored colony growth, the role of enterobactin as an iron uptake-facilitator would not explain its requirement for colony development. The absence of colony development was reverted either by addition of enterobactin, the reducing agent ascorbic acid or by incubating in anaerobic culture conditions with no additives. Then, we associated the enterobactin requirement for colony development with its ability to reduce oxidative stress, which we found to be higher in media where the colony development was impaired (M9) compared with media where the strain was able to form colonies (LB). Since oxyR and soxS mutants (two major stress response regulators) formed colonies in M9 agar medium, we hypothesize that enterobactin could be an  important piece in the oxidative stress response repertoire, particularly required in the context of colony formation. In addition, we show that enterobactin has to be hydrolyzed after reaching the cell cytoplasm in order to enable colony development. By favoring iron release, hydrolysis of the enterobactin-iron complex, not only would assure covering iron  needs, but would also provide the cell with a molecule with exposed hydroxyl groups (hydrolyzed enterobactin). This molecule would be able to scavenge radicals and therefore reduce oxidative stress.","palabras_clave":"Enerobactin|oxidative stress|colony development"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38443,"idioma_id":4,"titulo":"All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression","resumen":"Secondary infections due to post-sepsis immunosuppression are a major cause of death in patients with sepsis.Strategies aimed at restoring immune functions offer a new perspective in the treatment of sepsis. In the presentstudy, we used LPS (lipopolysaccharide)-immunosuppressed mice to analyse the effects of ATRA (all-trans retinoic acid) on different immune parameters. The IS (immunocompromised) group had decreased lymphocyte and increased MDSC (myeloid-derived suppressor cell) counts in lymph nodes. They also had an impaired in vitro T-cell proliferation, mediated by MDSCs. ATRA administration restored T-cell proliferation, which was associated with a decreased number of live MDSCs. The IS group treated with ATRA had an increased number of CD4+ and CD8+ T-cells. ATRA partially improved the primary humoral immune response, even when immunosuppression was established first and ATRA was administered  subsequently. Our results demonstrate that ATRA restores immunocompetence by modulating the number of leucocytes and the survival of MDSCs, and thus represents an additional potential strategy in the treatment of the immunosuppressive state of sepsis.","palabras_clave":"ATRA|LPS|MDSC|Gr-1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38444,"idioma_id":4,"titulo":"Ultrastructure of the oviductal mucosa of Leptodactylus chaquensis. Analysis of the pre and postovulatory period","resumen":"In the present study we analyzed the ultrastructural characteristics of the oviductal mucosa of Leptodactylus chaquensis during the preovulatory period and immediately after ovulation. Epithelial secretory cells, ciliated cells, basal cells and glandular secretory cells are described. During the preovulatory period, the oviduct exhibits its maximum degree of development at both the epithelial and the glandular level, with numerous secretory cells that contain a large number of secretory granules whose contents are released into the oviductal lumen by apocrine and exocytotic secretory processes. The secretory cells present throughout the oviduct display considerable variability in the characteristics of their secretory granules, which show different shapes, sizes, organization of the material contained and electron density. The different cell types are distributed following a characteristic pattern for each oviductal zone, thus creating an ultrastructural mosaic along the oviduct. During the postovulatory period, the number of secretory cells decreases and the remaining ones exhibit a marked reduction in secretory granules. Ciliated cells show a typical ultrastructural organization that is not modified throughout the reproductive cycle. Basal cells, located at the basal region of the ephitelium, are characterized by their heterochromatic nuclei and electronlucent cytoplasm, while glandular secretory cells exhibit oval, round or polyhedric granules, most of them with a prominent core. Our results, which indicate a high heterogeneity of secretory cell contents, allow us to suggest differential synthesis and secretion of specific products in each oviductal zone. immediately after ovulation. Epithelial secretory cells, ciliated cells, basal cells and glandular secretory cells are described. During the preovulatory period, the oviduct exhibits its maximum degree of development at both the epithelial and the glandular level, with numerous secretory cells that contain a large number of secretory granules whose contents are released into the oviductal lumen by apocrine and exocytotic secretory processes. The secretory cells present throughout the oviduct display considerable variability in the characteristics of their secretory granules, which show different shapes, sizes, organization of the material contained and electron density. The different cell types are distributed following a characteristic pattern for each oviductal zone, thus creating an ultrastructural mosaic along the oviduct. During the postovulatory period, the number of secretory cells decreases and the remaining ones exhibit a marked reduction in secretory granules. Ciliated cells show a typical ultrastructural organization that is not modified throughout the reproductive cycle. Basal cells, located at the basal region of the ephitelium, are characterized by their heterochromatic nuclei and electronlucent cytoplasm, while glandular secretory cells exhibit oval, round or polyhedric granules, most of them with a prominent core. Our results, which indicate a high heterogeneity of secretory cell contents, allow us to suggest differential synthesis and secretion of specific products in each oviductal zone. Leptodactylus chaquensis during the preovulatory period and immediately after ovulation. Epithelial secretory cells, ciliated cells, basal cells and glandular secretory cells are described. During the preovulatory period, the oviduct exhibits its maximum degree of development at both the epithelial and the glandular level, with numerous secretory cells that contain a large number of secretory granules whose contents are released into the oviductal lumen by apocrine and exocytotic secretory processes. The secretory cells present throughout the oviduct display considerable variability in the characteristics of their secretory granules, which show different shapes, sizes, organization of the material contained and electron density. The different cell types are distributed following a characteristic pattern for each oviductal zone, thus creating an ultrastructural mosaic along the oviduct. During the postovulatory period, the number of secretory cells decreases and the remaining ones exhibit a marked reduction in secretory granules. Ciliated cells show a typical ultrastructural organization that is not modified throughout the reproductive cycle. Basal cells, located at the basal region of the ephitelium, are characterized by their heterochromatic nuclei and electronlucent cytoplasm, while glandular secretory cells exhibit oval, round or polyhedric granules, most of them with a prominent core. Our results, which indicate a high heterogeneity of secretory cell contents, allow us to suggest differential synthesis and secretion of specific products in each oviductal zone.","palabras_clave":"AMPHIBIAN|OVIDUCT|LEPTODACTYLUS CHAQUENSIS|MUCOSA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38445,"idioma_id":4,"titulo":"Homeostasis and secretion of calcium in the oviductal mucosa of amphibians. An immunohistochemical study","resumen":"The presence of a calcium pump, calbindin D-28KD and calmodulin in the secretory cells (SC) of the oviductal pars convoluta (PC) of Rhinella arenarum was established for the first time in amphibians using immunohistochemical techniques. Marked variations were observed in the localization and degree of expression of these proteins according to the duct segment and the period of the sexual cycle analyzed. During the preovulatory and ovulatory periods the calcium pump colocalized with calbindin D-28KD can be seen mainly in the apical border of the SC, which are located in the first zones of PC and synthesize and secrete the components of the inner jelly coat layers. These envelopes, which surround the oocytes, contain the molecules indispensable for fertilization, probably inducing the sperm acrosome reaction (AR). Our results suggest that calmodulin, colocalized with the calcium pump at the SC cytoplasmic level, would be involved in the active transport of the cation inside the secretory granules, maintaining adequate levels of intracellular Ca2+ . During the postreproductive period, a calcium pump colocalized with calbindin D-28KD appears for the first time in the cycle in the basal zones of the SC. This system would be related to the replenishing of intracellular Ca2+  stores.  Whereas in Rhinella arenarum the Ca2+  present in the jelly coats that surrounded the oocytes participates in the AR during fertilization, this secretion system of the cation provided by the oviductal mucosa is functionally more active during the reproductive period of this species, when the factors involved in the gamete interaction are necessary.","palabras_clave":"AMPHIBIAN|CALCIUM|FERTILIZATION|REPRODUCTIVE CYCLE|TRANSCELLULAR TRANSPORT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38446,"idioma_id":4,"titulo":"Innervation of amphibian reproductive system. Histological and ultrastructural study","resumen":"In the present study we describe for the first time in anuran amphibians the histological and ultrastructural characteristics of innervation in the female reproductive organs. The observations in Rhinella arenarum revealed the presence of nerve fibers located predominantly in the ovarian hilium and in the oviduct wall. In both organs the nerves fibers are placed near blood vessels and smooth muscles fibers. In the present study the histological observations were confirmed using antibodies against peripherin and neurofilament 200 proteins. Ultrastructural analyses demonstrated that the innervation of the reproductive organs is constituted by unmyelinated nerve fibers surrounded by Schwann cells. Axon terminals contain a population of small, clear, translucent vesicles that coexist with a few dense cored vesicles. The ultrastructural characteristics together with the immunopositive reaction to tyrosine hydroxylase of the nerve fibers and the type of synaptic vesicles present in the axon terminal would indicate that the reproductive organs of R. arenarum females are innervated by the sympathetic division of the autonomic nervous system.","palabras_clave":"AMPHIBIAN|OVARY|OVIDUCT|INNERVATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38447,"idioma_id":4,"titulo":"The egg capsules and embryos of the patagonian gastropod Trophon plicatus (Lightfoot, 1786) (Caenogastropoda: Trophoninae) with remarks on the taxonomy of the southwestern atlantic Trophoninae","resumen":"Two species of Trophon are the most common muricids inPatagonian Atlantic waters, i.e. T. geversianus (Pallas, 1774)?type species of the type genus of the subfamily Trophoninae?and T. plicatus (Lightfoot, 1786). Trophon geversianus lives onintertidal and subtidal banks of mytilids (mainly Brachidontesspp.) along the Argentine coast. It ranges from the southerncoast of Buenos Aires province to Burdwood Bank in the southwesternAtlantic, and up the Pacific coast of southern Chile. It isa characteristic element of the Magellanic biogeographic province.The egg capsules are frequent and very visible because oftheir distinctive erect pedunculate shape and bright yellowcolour.","palabras_clave":"Gastropod|Ovicapsule|Trophon|Reproduction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38448,"idioma_id":4,"titulo":"Regulation of platelet responses triggered by Toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB","resumen":"INTRODUCTION:  Platelets express Toll-like receptors (TLRs) that recognise molecular components of pathogens and, in nucleated cells, elicit immune responses through nuclear factor-kappaB (NF-&#954;B) activation. We have shown that NF-&#954;B mediates platelet activation in response to classical agonists, suggesting that this transcription factor exerts non-genomic functions in platelets. The aim of this study was to determine whether NF-&#954;B activation is a downstream signal involved in TLR2 and 4-mediated platelet responses.  MATERIAL AND METHODS:  Aggregation and ATP release were measured with a Lumi-aggregometer. Fibrinogen binding, P-selectin and CD40 ligand (CD40L) levels and platelet-neutrophil aggregates were measured by cytometry. I kappa B alpha (I&#954;B&#945;) degradation and p65 phosphorylation were determined by Western blot and von Willebrand factor (vWF) by ELISA.  RESULTS:  Platelet stimulation with Pam3CSK4 or LPS resulted in I&#954;B&#945; degradation and p65 phosphorylation. These responses were suppressed by TLR2 and 4 blocking and synergised by thrombin. Aggregation, fibrinogen binding and ATP and vWF release were triggered by Pam3CSK4. LPS did not induce platelet responses per se, except for vWF release, but it did potentiate thrombin-induced aggregation, fibrinogen binding and ATP secretion. Pam3CSK4, but not LPS, induced P-selectin and CD40L expression and mixed aggregate formation. All of these responses, except for CD40L expression, were inhibited in platelets treated with the NF-&#954;B inhibitors BAY 11-7082 or Ro 106-9920.  CONCLUSION:  TLR2 and 4 agonists trigger platelet activation responses through NF-&#954;B. These data show another non-genomic function of NF-&#954;B in platelets and highlight this molecule as a potential target to prevent platelet activation in inflammatory or infectious diseases.","palabras_clave":"PLATELETS|TLR|NF-KB|INFLAMMATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38449,"idioma_id":4,"titulo":"PNPLA3, the history of an orphan gene of the potate tuber protein family that found an organ: the Liver. EDITORIAL.","resumen":"' To fall in love is to create a religion that has a fallible god' . Jorge Luis Borges 1952. The patatin-like phospholipase domain containing 3 gene (PNPLA3) was an orphan gene looking for a disease until 2008 when the first GWAS on NAFLD showed the association between the risk of liver fat accumulation and the nonsynonymous rs738409 C\/G variant (1). Months later, the variant was significantly associated with NAFLD disease severity (2) and ALT levels (3), and the role of PNPLA3 as a modifier of the natural history of NAFLD was unequivocally replicated in different populations around the world, from children to adult (4). The enthusiasm about PNPLA3 led to the search for other biologically plausible liver-disease associations, for instance, alcoholic liver disease (ALD) (5-7) and an increased risk of steatosis in patients with chronic hepatitis C (CHC) (8, 9) and B (10). The variant was not only associated with cirrhosis and the occurrence of hepatocellular carcinoma (HCC) (11), but the G allele was also identified as an independent risk factor for death and poor prognosis (12). At last, PNPLA3 found an organ: the Liver. In this issue, Trepo E et al. (13) explored the strength of the association between the rs738409 and the prevalence of HCC in cirrhotic patients by means of a meta-analysis of 2503 individual participant data (IPD) from Europe. The authors found that the risk allele G was significantly associated with HCC (OR per allele=1.77), after adjusting for sex, age, and obesity. Although the association was also found in patients with HCV-related cirrhosis (OR=1.55), in which the variant showed a small but statistically significant effect on the risk of HCC, the effect was more pronounced among patients with ALD (OR=2.20), suggesting that the variant influence is stronger, if not exclusive, on fat-derived HCC. Altogether, these results suggest some reflections: (a) The rs738409 is the most consistent genetic modifier of the natural history of common chronic liver diseases in which inflammation and fibrogenesis are induced by environmental factors (dietary fat, alcohol, or viruses). (b) The rs738409 is consistently associated with disease progression in liver diseases in which liver fat accumulation matters (NAFLD, ALD, and also CHC). Hence, instead of being ?the cause? of the disease in terms of traditional monogenic disorders, the variant seems to be an important link between environmental stressors and the susceptibility of the liver to develop a more aggressive phenotype. (c) From a theoretical perspective, it can be argued that the rs738409 has per se a substantial role in hepatocarcinogenesis because the variant is involved in related histological outcomes, such as steatosis and inflammation (4). Because the report of Trepo et al. is a cross-sectional study, we cannot rule out the possibility that patients enrolled in this meta-analysis have had fatty liver prior to developing cirrhosis, thus, we do not know whether carriers of the G allele that developed HCC were those who had increased susceptibility to steatosis (in other terms, adjustment by steatosis). Considering that IPD is a unique opportunity to have full access of patients´ record, it would have been interesting to know whether the association between the variant and HCV-HCC remained significant after adjusting for well-known risk factors of HCC development, such as viral load and genotype; undoubtedly, this finding should be confirmed in a better than 0.6 powered sample. Moreover, adjustment by insulin resistance would have been desirable in both cohorts. Also, to be generalized these results should be replicated in non European patients.&nbsp;&nbsp; Hence, to fall in love with the idea that PNPLA3 is per se involved in hepatocarcinogenesis is to create a hypothesis that has a priori a fallible biological plausibility. We can envision some questions raised by the readers. For example, clinicians may ask: &nbsp;If I have a patient with cirrhosis who carries the GG genotype, should I make a quick decision to reach an early diagnosis and treatment of HCC?&nbsp; In other words, are the results from PNPLA3 test clinically applicable? According to Trepo et al., the probability with which HCC will occur in carriers of the G variant is ~64% higher per allele (OR 1.77 converted to absolute risk). In terms of personalized medicine, the rs738409 is still not a feasible predictive test that can accurately discriminate between individuals who will develop HCC and those who will not, because very large ORs (probably over 10-200 to increase the AUC in a ROC curve) are typically needed to improve predictive accuracy above that provided by clinical information. People from the genomic world may ask: Why did previous GWAS on HCC not uncover the PNPLA3 association? Although a comprehensive search of markers encompassing the entire genome was previously performed on the risk of CHC-induced HCC (14, 15), SNPs at PNPLA3 were not identified. There are a number of explanations for this lack of association: (i) small effects for which GWAS are underpowered to detect owing to the large number of tested SNPs and the need of multiple testing correction; (ii) spurious associations; (iii) the ?missing heritability? explained by epistasis and gene-environmental interactions, and so forth. The simplest explanation is that hypothesis-driven candidate gene studies still have a place for the understanding of the genetic architecture of complex traits using approaches such as the one described by Trepo et al. Finally, scientists may wonder whether PNPLA3 has another function in addition to the known triacylglycerol lipase and acylglycerol O-acyltransferase activities that explain a putative role in liver injury and carcinogenesis. The identification of the molecular mechanisms by which the rs738409 is linked to hepatocarcinogenesis is certainly challenging because, disappointedly, the mechanisms by which the variant modulates cancer-linked phenotypes, such as inflammation and fibrogenesis, still remain unknown. In silico analysis of interaction pathways of PNPLA3 suggests that some of the genes on the pathway are involved in the release of arachidonic acid and prostaglandin E2 (Fig. 1), a finding previously associated with the transition from steatosis to NASH (16). Nevertheless, there are many things we do not know; for example, the impact of the variant on chromatin structure, and how these changes might impact on the transcriptional machinery that orchestrates PNPLA3- related network. Putative mechanisms associated with PNPLA3, epigenetic changes and hepatocarcinogenesis are depicted in Fig. 1. Finally, we do not know almost anything about the role of PNPLA3 on the liver function beyond its participation in lipid remodeling. A recent report showed that pnpl3 knocking down in zebrafish decreased the expression of hepatic progenitor cells and significantly impacted on liver growth and global homeostasis (17). This finding allows us to speculate that PNPLA3 might exert a phospholipase D6 (PLD6)-like activity, which may modulate the biogenesis of Piwi-interacting RNAs (piRNAs, small RNAs associated with proteins of the Argonaute family) or even regulate the release of phosphatidic acid on the mitochondrial surface (Fig. 1). In summary, we learned that PNPLA3 is associated with increased liver fat accumulation and, consequently, with inflammation and even fibrosis. We need to re-focus our research on both the physiologic role of the PNPLA3 on the human liver and the pathogenic role of the rs738409 on the progression of liver diseases, including liver cancer. ","palabras_clave":"PNPLA3|HEPATOCARCINOMA|POLYMORPHISMS|SYSTEMS BIOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38450,"idioma_id":4,"titulo":"Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals","resumen":"Epidemiological studies suggested that the prevalence and the disease severity of nonalcoholic fatty liver disease (NAFLD) are lower for people who drink modest amounts of alcohol than those who are abstainers. Nevertheless, the evidence is still inconclusive because some recently published studies [1] showed that modest alcohol consumption increases hepatic fat without increasing the risk of advanced fibrosis. Remarkably, we also found in the Argentinean population that modest alcohol consumption (MAC) has a beneficial effect not only on NAFLD but on various components of the metabolic syndrome, including body mass index (BMI), blood pressure, HOMA-IR, and C-reactive protein levels. Accordingly, NAFLD and NASH prevalence, liver enzymes, and inflammatory markers were also lower in subjects who took modest amounts of alcohol than those who are abstainers (Table 1). Hence, we propose to take advantage of meta-analysis to estimate from published data the effect of MAC on the odds of having NAFLD to give a quantitative assessment of this relationship. Thus, we addressed two different relevant clinical questions. Is MAC associated with lower prevalence of NAFLD? Data regarding MAC and NAFLD was extracted from eight heterogeneous (I2:80.7, p&lt;0.0001) studies [1-8] that were meta-analyzed along with our own data; the analysis included 43,175 adult individuals (30,791 non drinkers and 12,384 modest drinkers). The analysis showed that MAC was associated with a significant protection from the odds of having NAFLD in both fixed (OR 0.688, 95% CI: 0.646?0.733, p&lt;10&#8722;8) and random models (OR 0.684, 95% CI: 0.580?0.806, p&lt;10&#8722;5), regardless of studies being general population or hospital-based ones (Figure 1). This beneficial effect seems to be independent of covariates such as BMI (meta-regression analysis showed that this association was independent of BMI (slope= 0.01, p&lt;0.44), but is much influenced by sex. Of note, among women (n: 12,459), the protective effect of MAC on NAFLD was surprisingly higher (about 53%), when compared with men (about 30%). The female paradox is an interesting finding of our study because, while a large body of evidence suggest that women require less amount of alcohol to cause liver toxicity [9], MAC has a stronger protective effect on NAFLD in women.Is MAC associated with lower prevalence of NASH among those with NAFLD?MAC was found to have a significant protective effect on the development of NASH in both fixed and random model (OR 0.501, 95% CI: 0.340?0.740, p&lt;0.0005), without any evidence of heterogeneity (p: NS, I2: 0), data from 822 patients (550 non drinkers and 272 modest drinkers) diagnosed by liver biopsy in our population and 2 additional studies [2;10]. Thus, NAFLD patients who had MAC were more likely to have simple steatosis as opposed to NASH than abstainer patients. In conclusion, quantitative evidence showed that MAC is associated with a significant protective effect of about 31% on the risk of having NAFLD. Even more remarkable, MAC was associated with an average protective effect of about 50% on the risk of developing an advanced disease stage.Future research agenda still remains open, looking for answers from cohort prospective studies elucidating the exact role of modest alcohol consumption on the natural history of NAFLD. In addition, further exploration in future epidemiological studies should answer the question of whether different kinds of beverages are equally beneficial and are equally able to protect against NAFLD. Meanwhile, the deleterious effects of excess drinking must always be highlighted to NAFLD patients, but they might be allowed to drink low amounts of alcohol, including a narrow window between maximum protection and harm, which is not the same in men and women.","palabras_clave":"NAFLD|ALCOHOL|ALT|NASH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38451,"idioma_id":4,"titulo":"Promoter DNA Methylation of Farnesoid X Receptor and Pregnane X Receptor Modulates the Intrahepatic Cholestasis of Pregnancy Phenotype","resumen":"The intrahepatic cholestasis of pregnancy (ICP) is a multifactorial liver disorder which pathogenesis involves the interplayamong abnormal bile acid (BA) levels, sex hormones, environmental factors, and genetic susceptibility. The dynamic natureof ICP that usually resolves soon after delivery suggests the possibility that its pathobiology is under epigenetic modulation.We explored the status of white blood peripheral cells-DNA methylation of CpG-enriched sites at the promoter of targetedgenes (FXR\/NR1H4, PXR\/NR1I2, NR1I3, ESR1, and ABCC2) in a sample of 88 ICP patients and 173 healthy pregnant women inthe third trimester of their pregnancies. CpG dinucleotides at the gene promoter of nuclear receptors subfamily 1 membersand ABCC2 transporter were highly methylated during healthy pregnancy. We observed significant differences at the distal(21890) and proximal promoter (2358) CpG sites of the FXR\/NR1H4 and at the distal PXR\/NR1I2 (21224) promoter, whichwere consistently less methylated in ICP cases when compared with controls. In addition, we observed that methylation atFXR\/NR1H4, PXR\/NR1I2, NR1I3, ESR1, and ABCC2) in a sample of 88 ICP patients and 173 healthy pregnant women inthe third trimester of their pregnancies. CpG dinucleotides at the gene promoter of nuclear receptors subfamily 1 membersand ABCC2 transporter were highly methylated during healthy pregnancy. We observed significant differences at the distal(21890) and proximal promoter (2358) CpG sites of the FXR\/NR1H4 and at the distal PXR\/NR1I2 (21224) promoter, whichwere consistently less methylated in ICP cases when compared with controls. In addition, we observed that methylation atABCC2 transporter were highly methylated during healthy pregnancy. We observed significant differences at the distal(21890) and proximal promoter (2358) CpG sites of the FXR\/NR1H4 and at the distal PXR\/NR1I2 (21224) promoter, whichwere consistently less methylated in ICP cases when compared with controls. In addition, we observed that methylation at21890) and proximal promoter (2358) CpG sites of the FXR\/NR1H4 and at the distal PXR\/NR1I2 (21224) promoter, whichwere consistently less methylated in ICP cases when compared with controls. In addition, we observed that methylation atFXR\/NR1H4-1890 and PXR\/NR1I2-1224 promoter sites was highly and positively correlated with BA profiling, particularly,conjugated BAs. Conversely, methylation level at the proximal FXR\/NR1H4-358 CpG site was significantly and negativelycorrelated with the primary cholic and secondary deoxycholic acid. In vitro exploration showed that epiallopregnanolonesulfate, a reported FXR inhibitor, regulates the transcriptional activity of FXR\/NR1H4 but seems to be not involved in themethylation changes. In conclusion, the identification of epigenetic marks in target genes provides a basis for theunderstanding of adverse liver-related pregnancy outcomes, including ICP.\/NR1H4-1890 and PXR\/NR1I2-1224 promoter sites was highly and positively correlated with BA profiling, particularly,conjugated BAs. Conversely, methylation level at the proximal FXR\/NR1H4-358 CpG site was significantly and negativelycorrelated with the primary cholic and secondary deoxycholic acid. In vitro exploration showed that epiallopregnanolonesulfate, a reported FXR inhibitor, regulates the transcriptional activity of FXR\/NR1H4 but seems to be not involved in themethylation changes. In conclusion, the identification of epigenetic marks in target genes provides a basis for theunderstanding of adverse liver-related pregnancy outcomes, including ICP.FXR\/NR1H4-358 CpG site was significantly and negativelycorrelated with the primary cholic and secondary deoxycholic acid. In vitro exploration showed that epiallopregnanolonesulfate, a reported FXR inhibitor, regulates the transcriptional activity of FXR\/NR1H4 but seems to be not involved in themethylation changes. In conclusion, the identification of epigenetic marks in target genes provides a basis for theunderstanding of adverse liver-related pregnancy outcomes, including ICP.FXR\/NR1H4 but seems to be not involved in themethylation changes. In conclusion, the identification of epigenetic marks in target genes provides a basis for theunderstanding of adverse liver-related pregnancy outcomes, including ICP.","palabras_clave":"INTRAHEPATIC CHOLESTASIS OF PREGANCY|FXR|DNA METHYLATION|BILIARY ACID|PXR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38452,"idioma_id":4,"titulo":"Genetic and Epigenetic Associations with NAFLD: Focus on Clinical Decision Making and Novel Concepts in Disease Pathogenesis","resumen":"Nonalcoholic fatty liver disease (NAFLD) is a complex liver disease with worldwide prevalence. Its development involves a myriad of factors, including genetic susceptibility and environmental insults. In this review, we summarize new findings about current genome-wide association studies on NAFLD. In addition, we used a strategy of functional enrichment analysis to integrate all the newly discovered loci into common biological pathways and to explore their role in the pathogenesis of NAFLD. Controversies on the application of genetic testing to predict disease severity are discussed and specifically the role of rs738409 in clinical decision making. Finally, we highlighted significant trends and developments in epigenetic changes and microRNAs associated with disease progression.","palabras_clave":"GENETICS|EPIGENETICS|NAFLD|PERSONALIZED MEDICINE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38453,"idioma_id":4,"titulo":"Accuracy of the composite somatic cell count to detect intra-mammary infection in dairy cows using latent class analysis","resumen":"The somatic cell count (SCC) is considered an important indicator of intramammary infection (IMI). The purpose of this study was to determine the accuracy of both SCC and culture to detect IMI and their conditional dependence by means of latent class methods. This study involved 175 dairy cows from 2 herds with different udder infection prevalences. Quarter and composite milk samples were collected for SCC and bacteriological culture. Latent-class models using Bayesian methods were used to estimate test sensitivity (Se) and specificity (Sp) and population prevalence. The models ran involved only major mastitis pathogens and composite SCC (CSCC). Five thresholds between 100,000 and 300,000 cells\/ml were evaluated and the receiver operating characteristics (ROC) curve analysis was performed. Fifty five percent of the cows had CSCC &#8805;200,000 cells\/mL and 95.4% of the cows had at least one infected quarter either with minor or major pathogens. Considering a threshold of 150,000 cells\/mL, the estimated Se and Sp for the CSCC were, 0.80 (95% CrI 0.71-0.88) and 0.57 (95% CrI 0.44-0.71), respectively. The estimated culture Se and Sp were 0.83 95% CrI 0.73-0.93) and 0.89 (95% CrI 0.74-0.98), respectively. There was no evidence of dependence between CSCC and culture. The area under curve for CSCC was 0.72. To the best of our knowledge, this is the first report of the CSCC accuracy to detect IMI for major pathogens considering the effect of culture misclassification. The estimates provided here could help to examine the performance of sampling schemes based on CSCC to manage udder health.","palabras_clave":"test validation|somatic cell count |mastitis|bayesian methods"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38454,"idioma_id":4,"titulo":"Modified b-Cyclodextrin Inclusion Complex to Improve the Physicochemical Properties of Albendazole. Complete In Vitro Evaluation and Characterization","resumen":"The potential use of natural cyclodextrins and their synthetic derivatives have been studied extensively in pharmaceutical  research and development to modify certain properties of hydrophobic drugs. The ability of these host molecules of  including guest molecules within their cavities improves notably the physicochemical properties of poorly soluble drugs,  such as albendazole, the first chosen drug to treat gastrointestinal helminthic infections. Thus, the aim of this work was to  synthesize a beta cyclodextrin citrate derivative, to analyze its ability to form complexes with albendazole and to evaluate its  solubility and dissolution rate. The synthesis progress of the cyclodextrin derivative was followed by electrospray mass  spectrometry and the acid-base titration of the product. The derivative exhibited an important drug affinity. Nuclear  magnetic resonance experiments demonstrated that the tail and the aromatic ring of the drug were inside the cavity of the  cyclodextrin derivative. The inclusion complex was prepared by spray drying and full characterized. The drug dissolution  rate displayed exceptional results, achieving 100% drug release after 20 minutes. The studies indicated that the inclusion  complex with the cyclodextrin derivative improved remarkably the physicochemical properties of albendazole, being a  suitable excipient to design oral dosage forms.","palabras_clave":"Modified b-Cyclodextrin  |Inclusion Complex |Albendazole|In Vitro Evaluation|Complete  and Characterization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38455,"idioma_id":4,"titulo":"-  Role of angiotensin II and oxidative stress on renal aquaporins expression in hypernatremic rats.","resumen":"he aim of this study was to assess whether endogenous Ang II and   oxidative stress produced by acute hypertonic sodium overload may   regulate the expression of aquaporin-1 (AQP-1) and aquaporin-2 (AQP-2)   in the kidney. Groups of anesthetized male Sprague-Dawley rats were   infused with isotonic saline solution (control) or with hypertonic   saline solution (Na group, 1&nbsp;M NaCl), either alone or with losartan   (10&nbsp;mg&nbsp;kg(-1)) or tempol (0.5&nbsp;mg&nbsp;min(-1)&nbsp;kg(-1)) during 2&nbsp;h. Renal   function parameters were measured. Groups of unanesthetized animals were   injected intraperitoneally with hypertonic saline solution, with or   without free access to water intake, Na+W, and Na-W, respectively. The   expression of AQP-1, AQP-2, Ang II, eNOS, and NF-kB were evaluated in   the kidney by Western blot and immunohistochemistry. AQP-2 distribution   was assessed by immunofluorescence. Na group showed increased   natriuresis and diuresis, and Ang II and NF-kB expression, but decreased   eNOS expression. Losartan or tempol enhanced further the diuresis, and   AQP-2 and eNOS expression, as well as decreased Ang II and NF-kB   expression. Confocal immunofluorescence imaging revealed labeling of   AQP-2 in the apical plasma membrane with less labeling in the   intracellular vesicles than the apical membrane in kidney medullary   collecting duct principal cells both in C and Na groups. Importantly,   our data also show that losartan and tempol induces a predominantly   accumulation of AQP-2 in intracellular vesicles. In unanesthetized rats,   Na+W group presented increased diuresis, natriuresis, and AQP-2   expression (112&#8201;±&#8201;25 vs 64&#8201;±&#8201;16; *p&#8201;&lt;&#8201;0.05). Water deprivation   increased plasma sodium and diuresis but decreased AQP-2 (46&#8201;±&#8201;22 vs   112&#8201;±&#8201;25; §p&#8201;&lt;&#8201;0.05) and eNOS expression in the kidney. This study is   a novel demonstration that renal endogenous Ang II-oxidative stress,   induced in vivo in hypernatremic rats by an acute sodium overload,   regulates AQP-2 expression.","palabras_clave":"ANGIOTENSIN II|SODIUM OVERLOAD|AQUOPORIN|OXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38456,"idioma_id":4,"titulo":"Thermoluminescent kinetics for negligible retrapping: Its application to the analysis of the glow curve of Y2O3: Eu+3","resumen":"In this article a novel algorithm for analysing glow peaks resulting from traps having negligible retrapping is reported. The algorithm features two advantages: (1) an expression for the light intensity has been derived without resorting to the quasi-equilibrium approximation, and (2) no differential equation has to be integrated. The algorithm has been employed for analysing the main glow peak of Y2O3: Eu+3.","palabras_clave":"THERMOLUMINESCENCE|KINETICS|GLOW CURVE DECONVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38457,"idioma_id":4,"titulo":"Atheroprotective remodelling of vascular dermatan sulphate proteoglycans in response to hypercholesterolaemia in a rat model","resumen":"  Abstract: Proteoglycan accumulation within the arterial intima has been implicated in lipoprotein retention and atherosclerosis progression in humans. Nevertheless, hypercholesterolemia is unable to induce intimal thickening and atheroma plaque development in rats. The present study was performed to analyze quantitative and structural modification of proteoglycans in rats fed with a high-cholesterol diet, to understand whether vascular wall remodeling protects against atheroma lesion. Serial sections obtained from rat aortas showed normal features, in terms of intimal-to-media ratio and lipid accumulation. However, focal endothelial hyperplasia and neointima rearrangement were observed in the animals fed the high-cholesterol diet. In addition, hypercholesterolemia induced an increase in tumor necrosis factor alpha messenger RNA. We also determined the expression of proteoglycans (decorin, biglycan, versican and perlecan) from isolated aortic cells by Western blot and observed a diminished expression of dermatan sulfate proteoglycans (decorin and biglycan) in high-cholesterol animals compared with the control group (p&lt; 0.01and p&lt;0.05; respectively). Versican was increased in high-cholesterol animals (p&lt;0.05), whereas perlecan expression showed no differences. No modification of the total content of glycosaminoglycans was found between the two experimental groups. In contrast, the chondroitin sulfate \/dermatan sulfate ratio was increased in the highcholesterol group as compared to the control group (0.56 and 0.34, respectively). Structural alterations in the disaccharides composition of galactosaminoglycans were also detected by HPLC, as the ratio of 6-sulfate to 4-sulfate disaccharides was increased in high-cholesterol animals (p&lt; 0.05). Our results suggest that attenuation of decorin and biglycan expression might be an effective strategy to inhibit the irst step in atherogenesis, although specific glycosaminoglycan structural modification associated with the development of vascular disease took place. These findings support an early response of aortic cells to hypercholesterolemia and emphasize the potential application of therapies based on vascular matrix remodeling to treat atherosclerosis.","palabras_clave":"ATHEROSCLEROSIS|ENDOTHELIAL CELLS|SMOOTH MUSCLE CLLS|EXTRACELLULAR MATRIX|PROTEOGLYCANS|GLYCOSAMINOGLYCANS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38458,"idioma_id":4,"titulo":"cDNA isolation and characterization of two vitellogenin genes in the Chagas disease vector Triatoma infestans (Hemiptera, Reduviidae)","resumen":"Two vitellogenin genes (Vg1 and Vg2) were identified in the Chagas´ disease vector Triatoma infestans. The putative coding sequence corresponding to Vg2 was found to be 5553 bp long, encoding 1851 amino acids in a single open reading frame. The comparative analysis of the deduced amino acid sequences from Vg1 and Vg2 cDNA fragments of T. infestans revealed 58.94% of identity with 76.43% of homology. The phylogenetic tree based on the complete Vg amino acid sequences of hemimetabolous insects unambiguously supported two clusters, one consisting of Vg sequences from dictyopteran and the other containing Vg sequences of hemipteran. The Vg1 and Vg2 mRNAs were detected in fat bodies and ovaries of adult females with the highest levels of both Vg transcripts in the first tissue. Quantitative PCR showed low expression of Vg2 in head and muscle of adult females, while the Vg1 transcript was not present in these organs. Neither Vg1 nor Vg2 was expressed in fifth  instar nymph fat bodies or in adult male fat bodies, heads, and muscles.","palabras_clave":"vitellogenin |chagas|triatoma infestans"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38459,"idioma_id":4,"titulo":"Set of Classical PCR Reactions for the Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance.","resumen":"Clinical echinocandin resistance is increasing among Candida glabrata especially in US. Antifungal susceptibility testing is considered mandatory to guide therapeutic decisions. However, these methodologies are not routinely performed in the hospital setting due to its complexity and the time needed to obtain reliable results. Echinocandin failure in C. glabrata is linked exclusively to Fks1p and Fks2p amino acid substitutions and its detection would serve as surrogate marker to identify resistant isolates. In this work, we report an inexpensive, simple and quick classical PCR set of reactions able to objectively detect the most common mechanisms of echinocandin resistance in C. glabrata within four hours. The usefulness of this assay was assessed using a blinded collection of 50 C. glabrata strains including 16 FKS1 and\/or FKS2 mutants. ","palabras_clave":"CANDIDA|GLABRATA|RESISTENCIA|EQUINOCANDINAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38460,"idioma_id":4,"titulo":"Morfological indicators of initial reproductive commitment in Mustelus schmitti (Chondrichthyes, Triakidae): folliculogenesis and ovarian structure along the life cycle","resumen":"This work provides information about the sexual commitment and the folliculogenesis of the gatuzo, Mustelus schmitti. A total of 112 females of all maturity stages were fished in the Bahía Blanca estuary, between 2009 and 2010. The oogonia were present all along the life cycle of the animals. The folliculogenesis follows a pattern similar to other elasmobranchs. The granulosa layer keeps monolayered throughout the folliculogenesis, but with two cell types in the vitellogenic follicle. The zona pellucida forms in the primordial follicles. The thecal system shows a connective inner layer and a glandular outer sheath. The microscopic beginning of the sexual commitment, indicated by the vitello hoarding, takes place in follicles from 500 micrometers, while the macroscopic evidence appears in follicles of 2500-3000 micrometers. The results presented in this study suggest that the fishery pressure may affect a susceptible range of sizes of the species, not previously considered and provides a biological framework for the development of fisheries police.","palabras_clave":"Chondrichthyes|Mustelus schmitti|ovary"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38461,"idioma_id":4,"titulo":"Second order multivariate curve resolution of Fourier Transform Infrared Spectroscopic data of the photo-induced crosslinking of thymine functionalized polymers","resumen":"A meaningful characterization of the photo-induced curing process of materials based on styrene   monomers functionalized with thymine and charged ionic groups was accomplished using FT-IR   spectroscopy in combination with second-order multivariate calibration algorithms. The polymer   composition as well as the irradiation dose effects on the photo-crosslinking of copolymer films was   experimentally determined. Each FT-IR absorption spectra was decomposed into the contribution of   individual species by means of chemometric algorithms. A second-order strategy involving a three-  way array for each sample and analyzing all arrays simultaneously was used. Temperature and   solvent frequently have a strong influence on the FT-IR peak producing shifts and trilinearity lost. A   new methodology to properly pre-align the spectroscopic matrix data is used based on the   decomposition of a three-way array via a suitably initialized and constrained PARAFAC model. The   chemical reaction mechanism describing the underlying process in terms of identifiable steps was   determined. Associated key parameters and equilibrium rate constants that characterize the   interconversion and stability of diverse species were predicted. Additionally, it was possible to   quantify all the species even in the presence of a non-calibrated compound.","palabras_clave":"THYMINE|MCR-ALS|FT-IR|SECOND ORDER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38462,"idioma_id":5,"titulo":"La Educación en Derechos Humanos en el nivel superior.  Apuntes del presente","resumen":"                    El artículo refleja el trabajo llevado a cabo por el equipo de investigación del Centro de DDHH de la Universidad Nacional de Quilmes hasta este momento -y que cuenta con sus inicios hace ya más de 10 años atrás- sobre  las actividades curriculares y extracurriculares y la propuesta pedagógica que  ofrecen las distintas universidades nacionales sobre aspectos inherentes a la educación en derechos humanos.  Se trata de construir un mapa del conocimiento sobre la temática y analizar los  contenidos y supuestos, así como la ubicación relativa que tienen los diferentes abordajes dentro del  sistema educativo público y universitario. De este modo, se busca dar cuenta del estado real de  la enseñanza de derechos humanos en contextos muy heterogéneos y con gestiones universitarias no siempre articuladas.  ","palabras_clave":"EDUCACION|DERECHOSHUMANOS|UNIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38463,"idioma_id":4,"titulo":"Porous mullite ceramics formed by direct consolidation using native and granular cold-water-soluble starches","resumen":"In this article, the processing and microstructures of porous mullite bodies prepared by modifying the conventional route of the starch consolidation casting method were studied. The proposed route, called the 'soluble route', involves the use of native starches (i.e., potato, cassava, and corn starches) and a synthesized granular cold-water-soluble (GCWS) starch. Stable aqueous mullite-starch suspensions (0.25 starch volume fraction of 40 vol% total solids) were prepared by mixing. The total starch content was a mixture of ungelatinized native starch and GCWS starch with a 1:10 ratio of GCWS starch to total starch. Steady-state shear flow properties of the suspensions were analyzed by measuring viscosity. The addition of CGWS starch increased the starting suspension viscosity and thus prevented the particle segregation. Porous mullite bodies were obtained by heating (80°C, 2 h) the suspensions in metallic molds and by drying (40°C, 24 h) and sintering (1650°C, 2 h) the green disks after burning out the starch (650°C, 2 h). Green bodies obtained before and after the burning-out process, and the sintered disks were characterized with density and porosity measurements (Archimedes method) and microstructural analysis by scanning electron microscopy. The phases generated after the sintering process were determined by X-ray diffraction analysis, and pore size distributions were studied by Hg-porosimetry. The obtained results showed that the use of the GCWS starch made the shaping of homogeneous mullite bodies without cracks or deformations possible along with the development of controlled porous microstructures. © 2014 The American Ceramic Society.","palabras_clave":"Starch direct consolidation|Granular cold-water-soluble starch |Porous ceramics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38464,"idioma_id":4,"titulo":"Analysis of the discrepancies between the vertical reference frames of Argentina and Brazil","resumen":"The vertical reference frames for Argentina and Brazil present discrepancies due to their diferent datums and realizations. Thus, since 2008, we have started a series of activities with the aim of unifying the Argentine and Brazilian national vertical networks (NVNs). To achieve this goal, we have connected the two NVNs at three border points by using the geodetic levelling approach. Additionally, the gravity field approach was also applied, based on a suitable representation of the geoid by considering the Earth Gravitational Model (EGM2008) in its full resolution. In this regard, 1266 co-located Global Positioning System (GPS) and levelling benchmarks regularly distributed over Argentina (612) and Brazil (654) were considered. The geodetic levelling approach shows an offset value of 54 cm, which implies that the Argentine vertical reference frame is above that of the Brazilian vertical reference frame. However, the result of the gravimetric approach shows an offset of 57 cm, which implies a difference&nbsp;of approximatelly 3 cm between both methods.Hence, since Brazil and Argentina represent a significant part of South America, the solution to the datum problem between both countries could point towards a common vertical reference frame for the Atlantic side.","palabras_clave":"ARGENTINE AND BRAZILIAN LEVELLING NETWORKS|GEODETIC LEVELLING APPROACH|GRAVITY FIELD APPROACH|VERTICAL DATUM CONNECTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38465,"idioma_id":4,"titulo":"COLLABORATIVE ASTEROID PHOTOMETRY AND LIGHTCURVE ANALYSIS AT OBSERVATORIES OAEGG, OAC, EABA, AND OAS","resumen":"P { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 0); }P.western { font-family: 'Times New Roman',serif; font-size: 12pt; }P.cjk { font-family: 'DejaVu Sans',sans-serif; font-size: 12pt; }P.ctl { font-family: 'Lohit Hindi','Times New Roman'; font-size: 12pt; }A:link {  }              Synodic rotation periods and amplitudes are reportedfor: 1874 Kacivelia, 15.951 ± 0.001 h, 0.21 ± 0.02 mag;2055 Dvorak, 4.4052 ± 0.0003 h, 0.17 ± 0.04 mag; 2185Guangdong, 21.089 ± 0.002 h, 0.19 ± 0.02 mag; and8059 Deliyannis, 6.0041 ± 0.0003 h, 0.39 ± 0.04 mag.The absolute magnitude (H) and\/or slope parameter (G)for some of these asteroids are also reported.","palabras_clave":"Kacivelia|Delyannis|Dvorak|Guagdong"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38466,"idioma_id":4,"titulo":"Sorptional behaviour of rosehip leather formulations added with sucrose or polydextrose","resumen":"The sorptional behaviour of two formulations intended to develop rosehip leathers, both based on rosehip fruit pulp, was assessed experimentally. One formulation had sucrose added, while polydextrose was added to the other to reduce the calorie intake. Isotherms were measured by the static gravimetric method at 10, 20, 40 and 60 °C. The GAB equation and a model proposed by Leiva Díaz, Giannuzzi, and Giner (2009) gave the best representation of data for sucrose- and polydextrose-added formulations, respectively. A detailed statistical analysis revealed an interaction between composition and temperature effects on isotherms. Sucrose proved to be more effective than polydextrose to lowering the water activity of the formulation, except in conditions that favour the formation of sucrose crystals. In general, the water activity of the polidextrose-added formulation, which did not experience crystallisation, increased with increasing temperature for a given moisture content. However, the temperature effect on the isotherms of the sucrose-added matrix was more complex, possibly being affected by crystallisation.","palabras_clave":"ROSEHIP|SUCROSE|POLYDEXTROSE|ISOTHERM|WATER ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38467,"idioma_id":4,"titulo":"Surface behavior of sphingomyelins with very long chain polyunsaturated fatty acids and effects of their conversion to ceramides","resumen":"Molecular species of sphingomyelin (SM) with nonhydroxy (n) and 2-hydroxy (h) verylong-chain polyunsaturated fatty acids (n- and h-28:4, 30:5 and 32:5) abound in rat spermatogenic cells and spermatozoa. These SMs are located on the sperm head,where they are converted into the corresponding ceramides (Cer) after completion of the acrosomal reaction, as induced in vitro. The aim of this study was to look into the surface properties of these unique SM species and how these properties change by the SM&#8594;Cer conversion. After isolation by HPLC, these SMs were organized in Langmuir  films and studied alone, in combination with different proportions of Cer, and during their conversion into Cer by sphingomyelinase. Compression isotherms for all six SMs under study were compatible with a liquid-expanded (LE) state and showed large molecular areas. Only the longest SMs (n-32:5 and h-32:5 SM) underwent a phase transition upon cooling. On the other hand, the abundant h-28:4 Cer exhibited an  unusual highly compressible liquid-condensed (LC) phase, compatible with a high conformational freedom of Cer molecules but with the characteristic low diffusional properties of the LC phase. In mixed films of h-28:4 SM \/ h-28:4 Cer, the components showed a favourable mixing in the LE phase. The monolayer exhibited h-28:4 Cer-rich domains both in premixed films and when formed by the action of sphingomyelinase on  pure h-28:4 SM films. In conclusion, while the SMs from sperm behaved in a way similar to shorter acylated SMs, the corresponding Cers showed atypical rheological properties that may be relevant for the membrane structural rearrangements that take place on the sperm head after completion of the acrosomal reaction.","palabras_clave":"2-hydroxy fatty acids|Brewster angle microscopy|single particle tracking|Langmuir monolayers"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38468,"idioma_id":4,"titulo":"Towards the Use of Video Games for Learning: A Survey about Video Games  Preferences of Engineering Students","resumen":"Video games are now a widespread cultural practice, especially among young people, making them an ideal medium for the design of learning processes. In order to design educational technologies that provide teaching support we must first understand the practices developed by the young with computers and especially with video games. The aim of the present study is therefore to learn about the experience and expectations about video games among students, particularly engineering students. The results are going to be considered in the design of educational technologies based on interactive virtual environments that mediate the learning processes, particularly in physics course of engineering studies.","palabras_clave":"videojuegos|educacion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38469,"idioma_id":4,"titulo":"Morphological and immunochemical characterization of the pollen grains of Chenopodium album L. (Chenopodiaceae) in a temperate urban area in Argentina","resumen":"Chenopodium album es una hierba cosmopolita, anual,muy polimórfica, que crece en forma espontánea en baldíos con suelosmodificados de los barrios periféricos de Bahía Blanca. En estaciudad, el periodo de floración es principalmente entre febrero y marzo,que coincide con la mayor concentración de este tipo de polen enla atmósfera. El objetivo de este estudio fue caracterizar morfológicae inmunoquímicamente a los granos de polen de Chenopodium albumobtenidos en diferentes zonas del área urbana de la Bahía Blanca. Lasmuestras fueron colectadas en tres zonas de la ciudad. La estructura yla morfología de los granos fueron analizados con microscopía ópticay electrónica. Los perfiles proteicos y antigénicos fueron estudiadosmediante Tricine-SDS-PAGE y western blot, empleando un sueropoliclonal obtenido en conejo. El análisis morfológico mostró diferenciassignificativas en relación al diámetro de los granos de polenen una de las áreas estudiadas. En esa misma área se encontraron diferenciasen la expresión de proteínas, aunque el perfil antigénico fueconservado. Estas variaciones en la morfología y en el perfil proteicopodrían ser causadas por los efectos de las condiciones ambientalessobre el polen y la presencia de contaminantes urbanos provenientesdel tráfico vehicular.","palabras_clave":"CHENOPODIUM ALBUM L.|TRICINE-SDS-PAGE|WESTERN BLOT|PERFIL ANTIGÉNICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38470,"idioma_id":4,"titulo":"Spontaneous genetic damage in the tegu lizard (Tupinambismerianae): The effect of age","resumen":"Several studies indicate that certain factors such as age, sex or  nutritional status among others, may affect the level of DNA damage, both induced and spontaneous, so it is very important to consider them for a more accurate interpretation of the findings. The aim of this study was to analyze the influence of age, sex, and nest of origin on spontaneous genetic damage of Tupinambis merianae determined by the comet assay (CA) and the micronucleus (MN) test, in order to improve reference data for future in vivo studies of xenobiotics exposure in this species. Sixty-five tegu lizards of three different ages:newborns (NB), juveniles (JUV) and adults (AD), both sexes and from different nests of origin were used.Blood samples were collected from the caudal vein of all animals and the MN test and CA were applied on peripheral blood erythrocytes to determine basal frequency of MN (BFMN) and basal damage index(BDI). The comparison between age groups showed statistically significant differences in the BFMN and BDI (p  0.05). A weak negative relationship was found only between BFMN and weight of NB tegu lizard (p = 0.014; R2= 0.245). Basal values of genetic damage obtained with both biomarkers in the tegu lizard evidenced that age is an intrinsic factor that should be taken into account to avoid misunderstanding of the results in future biomonitoring studies.","palabras_clave":"BASAL GENETIC DAMAGE|COMET ASSAY|MICRONUCLEUS TEST|AGE|MONITORING|TEGU LIZARD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38471,"idioma_id":4,"titulo":"DNA Repair Activity of Ilex paraguariensis in Human Cells In Vitro","resumen":"Yerba mate (Ilex paraguariensis) has been consumed as popular infusions in South America for centuries, with potential beneficial effects on health. The aim of this study was to evaluate yerba mate antioxidant properties in human leucocytes exposed in vitro to oxidative damage, using the Comet assay.  Human cells were exposed to 10 &#956;M H2O2 and then allowed to repair with increasing concentrations of two different yerba mate infusions: 10 &#956;l\/mL, 100 &#956;l\/mL and 1000 &#956;l\/mL. Damage Index (DI) and the percentage  of damage reduction (%DR) were calculated. DI showed that both infusions produced similar protective effects (p > 0.05) and the %DR indicated a decreased in oxidative damage as infusion concentration increases (p < 0.05). The greatest protective effects were found using the highest concentration of mate (1000 &#956;l\/mL). Thus, we conclude that the regular ingestion of Ilex paraguariensis infusions could contribute to antioxidant defense on humans.","palabras_clave":"ILEX PARAGUARIENSIS|COMET ASSAY|ANTIOXIDANTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38472,"idioma_id":4,"titulo":"Dual therapy with lopinavir and ritonavir plus lamivudine versus triple therapy with lopinavir and ritonavir plus two nucleoside reverse transcriptase inhibitors in antiretroviral-therapy-naive adults with HIV-1 infection: 48 week results of the randomise","resumen":"Daily oral triple therapy is effective at halting HIV disease progression, but can have toxic effects and is costly. We investigated whether dual therapy with lopinavir and ritonavir plus lamivudine is non-inferior to standard triple therapy.","palabras_clave":"THERAPY|HIV"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38473,"idioma_id":4,"titulo":"Recombinant protein expression in Escherichia coli: advances and challenges","resumen":"Escherichia coli is one of the organisms of choice for the production of recombinant proteins. Its use as a cell factory is well-established and it has become the most popular expression platform. For this reason, there are many molecular tools and protocols at hand for the high-level production of heterologous proteins, such as a vast catalog of expression plasmids, a great number of engineered strains and many cultivation strategies. We review the different approaches for the synthesis of recombinant proteins in E. coli and discuss recent progress in this ever-growing field.","palabras_clave":"Expresión de proteínas|Proteínas heterólogas|Plásmidos de expresión|Escherichia coli"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38474,"idioma_id":4,"titulo":"Experimental selection of long-term intracellular mycobacteria","resumen":"Some intracellular bacteria are known to cause long-term infections that last decades without compromising the viability of the host. Although of critical importance, the adaptations that intracellular bacteria undergo during this long process of residence in a host cell environment remain obscure. Here, we report a novel experimental approach to study the adaptations of mycobacteria imposed by a long-term intracellular lifestyle. Selected Mycobacterium bovis&#8197;BCG through continuous culture in macrophages underwent an adaptation process leading to impaired phenolic glycolipids (PGL) synthesis, improved usage of glucose as a carbon source and accumulation of neutral lipids. These changes correlated with increased survival of mycobacteria in macrophages and mice during re-infection and also with the specific expression of stress- and survival-related genes. Our findings identify bacterial traits implicated in the establishment of long-term cellular infections and represent a tool for understanding the physiological states and the environment that bacteria face living in fluctuating intracellular environments.","palabras_clave":"persistence|BCG|tuberculosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38475,"idioma_id":4,"titulo":"Protective axis of the renin-angiotensin system in the brain","resumen":"The RAS (renin-angiotensin system) is composed of two arms: the pressor arm containing AngII (angiotensin II)\/ACE (angiotensin-converting enzyme)\/AT1Rs (AngII type 1 receptors), and the depressor arm represented by Ang-(1-7) [angiotensin-(1-7)]\/ACE2\/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1-7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1-7) is injected into the nucleus of the solitary tract, caudal ventrolateral medulla, paraventricular nucleus or anterior hypothalamic area, a reduction in BP occurs; however, when injected into the rostral ventrolateral medulla, Ang-(1-7) stimulates an increase in BP. In contrast with AngII, Ang-(1-7) improves baroreflex sensitivity and has an inhibitory neuromodulatory role in hypothalamic noradrenergic neurotransmission. Ang-(1-7) not only exerts effects related to BP regulation, but also acts as a cerebroprotective component of the RAS by reducing cerebral infarct size and neuronal apoptosis. In the present review, we provide an overview of effects elicited by Ang-(1-7) in the brain, which suggest a potential role for Ang-(1-7) in controlling the central development of hypertension.","palabras_clave":"ANGIOTENSIN-(1-7)|MAS|BRAIN|RENIN-ANGIOTENSIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38476,"idioma_id":5,"titulo":"Urbanos e iluminados","resumen":"Urbanos e iluminados  Leds y otras variantes económicas y sustentables han inundado la renovación del alumbrado público y las fachadas de nuestros  edificios más significativos, intentando construir una nueva mirada sobre la ciudad de siempre ahora desde la nocturnidad.  Estas propuestas novedosas que implican distintos modos de ver lo permanente, que aportan a los ?city by night?, fórmula turística de nocturnos recorridos urbanos entre edificios\/sectores\/ conjuntos\/rutas pensada para aquellos curiosos y noctámbulos, que son un sustancioso target del turismo cultural urbano, constantes e imprescindibles en aquellas ciudades consagradas turísticamente. Este recorrido nocturno ha logrado con sus novedades incrementar el tiempo de permanencia del turista en algunos destinos, que compiten entre sí en su afán de atraer y prolongar las visitas y concomitantemente sus gastos en la ciudad.   Es que a partir de la tendencia detectada en la reorganización de los tiempos del ocio, el tiempo libre y la recreación, preanunciada en los setenta por la OMT (Organización Mundial del Turismo www2.unwto.org\/es)  y concretada en la actualidad en dónde, del anterior mes familiar de descanso anual, generalmente de sol y playa, los turistas han pasado a distribuir sus períodos vacacionales en varios fines de semana largos distribuidos durante el año, con lo que el turismo urbano se ve favorecido en el corto plazo y  ha crecido sostenidamente desde entonces.  Es así que el caso de la ciudad de Girona, Cataluña, España, aclara a qué nos referimos. La planificadora en turismo catalana Marta Ministral i Masgrau, en un congreso de arquitectura y turismo en el año 2001, desarrollaba su relato acerca de la gran afluencia de turistas que provoca su bella Catedral románica y de cómo los planificadores pensaron, de acuerdo a estas tendencias señaladas anteriormente qué estrategia de marketing habría que implementar para aprovechar su encanto en otro producto turístico a diseñar y poner en mercado. Es entonces que a partir de una investigación que planteaba entre otras acciones entrevistas con los feligreses de la Catedral, se vieron sorprendidos por la cantidad de pequeñas historias que recabaron acerca de la misma, la mayoría de aparecidos y otras terroríficas cuestiones. Con ellas se desarrolló un discurso orientativo para los guías que reforzado por el diseño de la iluminación teatral temática, hicieron que la magia se produjera y la novedad fuera ampliamente aceptada por los turistas incrementando su permanencia en la ciudad.   Este relato viene a echar luz sobre aquellos eventos que necesitan de la oscuridad y por ello de la noche para poder desarrollarse, sin duda se requiere de una planificada elección de los sitios, ubicaciones y tipos de artefactos, colores, intensidad y relaciones entre el todo y las partes, para que como en Girona, la oferta sea coherente con la idea general del abordaje turístico y obviamente se manifieste a la altura y riqueza de los bienes a iluminar que generalmente son las fachadas de los monumentos patrimoniales.   ¿Quién desarrolla en nuestras ciudades los proyectos de iluminación arquitectónica mencionados?, es más ¿lo hace algún especialista o queda librado a las intenciones no profesionales? Y de ser así, ¿el desarrollador contempla sólo una cuestión técnico-práctica repetitiva o la novedad en el diseño también tracciona nuevos desafíos para la industria? Más aún, ¿se sustentan los proyectos lumínicos en la coherencia y claros conceptos interpretativos que ayuden a que el turista vea satisfecha su motivación al comprar el mencionado ?city by night?? Y finalmente, ¿hay alguna política pública en las ciudades que normatice esta práctica? O como dice ICOMOS (Consejo Internacional de Monumentos y Sitios www.icomosargentina.org ) y nos sumamos al preguntar: ¿el estado municipal ?? propicia su desarrollo coherente y adaptación armoniosa a la vida moderna.??  El control de la iluminación artística en monumentos y lugares urbanos significativos a través del más utilizado, el protocolo DMX (Digital Múltiple X), dispositivo usado en luminotecnia y control de efectos especiales, permite generar una muy peligrosa variedad y combinación de colores. En manos inexpertas o imaginaciones febriles, ello sería poco selecto haciendo escaso favor al bien alumbrado, ya que la iluminación de monumentos históricos debe cuidar aspectos que no sólo refieren al uso de tecnología de punta a través de LEDs, también al ocultamiento de las luminarias y artefactos en el edificio o sus jardines, a la cuidadosa planificación y organización temporal de los efectos y sobre todo a la coherencia entre la cromaticidad a plantear y la del propio bien a iluminar, un claro ejemplo es la acertada iluminación nocturna propuesta y desarrollada para la cúpula del Planetario de la Ciudad Autónoma de Buenos Aires, inaugurada en 2011.   Y la polémica recién empieza, polémica entre quienes conscientes del patrimonio y sus valores en cuanto a ayudar a la construcción de ciudadanía y al sentido y orgullo de pertenencia, entre los más destacables, aquellos que estamos a favor de la preservación de los bienes y su sostenimiento a lo largo del tiempo, preferimos los discretos tonos neutros que si bien son conservadores, no atentan contra una buena lectura del monumento como sí lo hace la parafernalia colorística a veces implantada.  Finalmente que ese proyecto lumínico no sea una cuestión puntual y aislada, sino que se articule a un proceso cultural más amplio que además y básicamente sea planificado integralmente.","palabras_clave":"PATRIMONIO|ARQUITECTURA|TECNOLOGÍA|TURISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38477,"idioma_id":4,"titulo":"Effect of acclimation medium on cell viability, membrane integrity and ability to consume malic acid in synthetic wine by oenological Lactobacillus plantarum strains","resumen":"Abstract  Aims: The aim of this work was to evaluate the effect of acclimation on the viability, membrane integrity  and technological properties of three oenological strains of Lact. plantarum exposed to wine conditions.   Methods and Results Cultures in the exponential phase were inoculated in an acclimation medium containing 6 and  10 % v\/v ethanol and incubated 48 hours at 28 °C. After incubation, cells were harvested by centrifugation and  inoculated in a synthetic wine, containing 14 % v\/v ethanol and pH 3.5. The membrane integrity was measured  determining the propidium iodide (PI) uptake by flow cytometry. Strains previously acclimated were inoculated in  synthetic wine, and incubated at 28 ºC without shaking. Bacterial growth and L-malic acid was monitored during 15  days.   In non-acclimated strains, the damage of bacterial membranes produced a rapid increase of PI uptake. At the same  time, a noticeable decrease of microbial viability was observed. Acclimation in both 6 % v\/v and 10 % v\/v ethanol,  noticeable increased the microbial viability of all the strains in synthetic wine.   Acclimation contributed to maintain the membrane integrity although the efficiency was strain dependent and  determined by the acclimation conditions.  Finally, the evolution of the viability and malolactic activity of acclimated strains grown in synthetic wine for 15  days could be correlated with the membrane integrity.  Conclusion: acclimation of oenological strains in media containing ethanol prior to inoculation of wines  significantly improves the viability and decreases the membrane damage in the harsh wine conditions. The role of  membrane integrity is crucial to guaranty the success of malolactic fermentation.  Significance and Impact of the Study: The efficiency of flow cytometry in monitoring membrane damage exposed  to the harsh wine conditions has a strong impact on winemaking because it represents a useful tool for a quick and  highly reliable evaluation of oenological parameters.","palabras_clave":"Acclimation medium|Ethanol stress|Lactobacillus plantarum|Malic acid consumptiom|Membrane damage|Wine"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38478,"idioma_id":4,"titulo":"Protection induced by a glycoprotein E-deleted bovine herpesvirus type 1 marker strain used either as an inactivated or live attenuated vaccine in cattle","resumen":"    BACKGROUND:     Bovine herpesvirus type 1 (BoHV-1)   is the causative agent of respiratory and genital tract infections;   causing a high economic loss in all continents. Use of marker vaccines   in IBR eradication programs is widely accepted since it allows for   protection of the animals against the disease while adding the   possibility of differentiating vaccinated from infected animals.The aim   of the present study was the development and evaluation of safety and   efficacy of a glycoprotein E-deleted (gE-) BoHV-1 marker vaccine strain   (BoHV-1&#916;gE&#946;gal) generated by homologous recombination, replacing the   viral gE gene with the &#946;-galactosidase (&#946;gal) gene.    RESULTS:     In   vitro growth kinetics of the BoHV-1&#916;gE&#946;gal virus was similar to BoHV-1   LA. The immune response triggered by the new recombinant strain in   cattle was characterized both as live attenuated vaccine (LAV) and as an   inactivated vaccine. BoHV-1&#916;gE&#946;gal was highly immunogenic in both   formulations, inducing specific humoral and cellular immune responses.   Antibody titers found in animals vaccinated with the inactivated vaccine   based on BoHV-1&#916;gE&#946;gal was similar to the titers found for the control   vaccine (BoHV-1 LA). In the same way, titers of inactivated vaccine   groups were significantly higher than any of the LAV immunized groups,   independently of the inoculation route (p&#8201;&lt;&#8201;0.001). Levels of IFN-&#947;   were significantly higher (p&#8201;&lt;&#8201;0.001) in those animals that received   the LAV compared to those that received the inactivated vaccine.   BoHV-1&#916;gE&#946;gal exhibited an evident attenuation when administered as a   LAV; no virus was detected in nasal secretions of vaccinated or sentinel   animals during the post-vaccination period. BoHV-1&#916;gE&#946;gal, when used in   either formulation, elicited an efficient immune response that   protected animals against challenge with virulent wild-type BoHV-1.   Also, the deletion of the gE gene served as an immunological marker to   differentiate vaccinated animals from infected animals. All animals   vaccinated with the BoHV-1&#916;gE &#946;gal strain were protected against disease   after challenge and shed significantly less virus than control calves,   regardless of the route and formulation they were inoculated.    CONCLUSIONS:     Based   on its attenuation, immunogenicity and protective effect after   challenge, BoHV-1&#916;gE&#946;gal virus is an efficient and safe vaccine   candidate when used either as inactivated or as live attenuated forms.","palabras_clave":"BoHV-1&#916;gE&#946;gal|BoHV-1 marker vaccine|Inactivated\/live attenuated vaccine|bovines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38479,"idioma_id":4,"titulo":"Docking applied to the prediction of the affinity of compounds to P- Glycoprotein","resumen":"P-Glycoprotein (P-gp) is involved in the transport of xenobiotic compounds and responsible for the decrease of the drug accumulation in multi drug-resistant cells. In this investigation we compare several docking algorithms in order to find the conditions that are able to discriminate P-gp binders and non-binders. We built a comprehensive data set of binders and non-binders based on a careful analysis of  the experimental data available in the literature, trying to overcome the  discrepancy noticeable in the experimental results. We found that Autodock Vina  flexible docking is the best choice for the tested options. The results will be useful to filter virtual screening results in the rational design of new drugs that are not  expected to be expelled by P-gp.","palabras_clave":"Glicoproteina P|Refractory Epilepsy|Docking"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38480,"idioma_id":4,"titulo":"Spatio-temporal dynamics of dengue 2009 outbreak in Córdoba City, Argentina","resumen":"During 2009 the biggest dengue epidemic to date occurred in Argentina, affecting almost half the country. We studied the spatio-temporal dynamics of the outbreak in the second most populated city of the country, Córdoba city. Confirmed cases and the results of an Aedes aegypti monitoring during the outbreak were geolocated. The imported cases began in January, and the autochthonous in March. Thirty-three percent of the 130 confirmed cases were imported, and occurred mainly in the center of the city. The autochthonous cases were more frequent in the outskirts, specially in the NE and SE. Aedes aegypti infestation showed no difference between neighborhoods with or without autochthonous cases, neither between neighborhoods with autochthonous vs. imported cases. The neighborhoods with imported cases presented higher population densities. The majority of autochthonous cases occurred at ages between 25 and 44 years old. Cases formed a spatio-temporal cluster of up to 20 days and 12 km. According to a mathematical model that estimates the required number of days needed for transmission according to daily temperature, the number of cases begun to fall when more than 15.5 days were needed. This may be a coarse estimation of mean mosquito survival in the area, provided that the study area is close to the global distribution limit of the vector, and that cases prevalence was very low.","palabras_clave":"DENGUE OUTBREAK|AEDES AEGYPTI|CORDOBA|ARGENTINA|GEOGRAPHIC INFORMATION SYSTEM (GIS)"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38481,"idioma_id":4,"titulo":"Technological and probiotic characterisation of Lactobacillus casei \/ paracasei strains and their phage resistant mutants","resumen":"Technological, biological and functional attributes of two groups of spontaneous bacteriophage-resistant mutants were investigated to verify features similar to those of their respective phage-sensitive parent probiotic strains (Lactobacillus casei\/paracasei). A derivative from each group was challenged with phages in simulated probiotic product fermentation. Technological performance, compared with the original strains, was demonstrated. Minimal variations were detected in acidifying and enzymatic profiles. No &#946;-glucuronidase activity was observed, but very high &#945;-glucosidase and &#946;-galactosidase activities were recorded. Low proteolytic activities and inability to ferment prebiotics were observed. Within one group, significant differences throughout simulated gastrointestinal-transit were observed. Neither of the strains deconjugated bile salts, but all showed inhibitory activity against four pathogens. Both mutants increased IgA-producing cell numbers in vivo in a manner similar to that of the parent strains. Two derivatives demonstrated improved phage-resistance phenotype compared with the parental strains, resulting in alternatives for industrial rotation schemes.","palabras_clave":"LACTOBACILLUS CASEI\/PARACASEI|RESISTANT MUTANTS|CHARACTERISATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38482,"idioma_id":4,"titulo":"Mycotoxins and Mycotoxigenic Fungi in Poultry Feed for Food-Producing Animals","resumen":"The intake of microbiological and\/or mycotoxin-contaminated feed has adverse effects on animal health and productivity. The presence of pathogenic microorganism can affect directly or indirectly human health. Mycotoxins may be carried over into meat and eggs when poultry are fed with contaminated feed. Feedstuff used for poultry nutrition in Argentina were analyzed for fungal flora, mycotoxins natural levels, and bacteriological and nutritional quality. Ten mold genera were recovered, six of them known to be mycotoxigenic. More than 28 species were determined. Fumonisins were detected in all the samples (median 1,750 ppb). Forty four out of 49 samples (90%) were contaminated with DON (median 222 ppb) and OTA (median 5 ppb). Also, 44 out of 49 samples were contaminated with aflatoxins (median 2.685 ppb), 42 samples (86%) with ZEA (median 50 ppb) and 38 samples (78%) with T2-toxin (median 50 ppb). All samples were negative for E. coli and counts for S. aureus were &gt;10 CFU\/g. Only one out of 49 samples was positive for Salmonella. Ninety percent of the samples had at least one type of nutritional deficiency. This kind of studies are relevant in order to feed animals for optimal performance ensuring the safety and nutritional quality of food.","palabras_clave":"ANIMAL FEEDS|MYCOTOXINS|MICROBIOLOGICAL QUALITY|NUTRITIONAL QUALITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38483,"idioma_id":4,"titulo":"Leuconostoc citreum MB1 as biocontrol agent of Listeria monocytogenes in milk","resumen":"Cell-free supernatant from Leuconostoc citreum MB1 revealed specific antilisterial activity. Preliminary studies demonstrated the proteinaceous, heat-stable, bacteriocin-like trait of the antimicrobial components present in the supernatant. Determination of the genes encoding bacteriocins by PCR and DNA sequencing led to amplification products highly homologous with leucocin A (found in diverse Leuconostoc species) and UviB (found in Leuc. citreum KM20) sequences. Additionally, antimicrobial activity of cell-free supernatant from Leuc. citreum MB1 was revealed by an inhibition halo of the SDS-PAGE gel subjected to a direct detection using Listeria monocytogenes as indicator strain. Different assays were carried out to assess the capacity of Leuc.citreum MB1 to control List. monocytogenes growth: i) inactivation kinetics of the pathogen by antilisterial compounds present in concentrated cell-free supernatant from Leuc. citreum MB1, ii) evaluation of optimal Leuc. citreum MB1 initial concentration to obtain maximum List. monocytogenes ATCC 15313 inhibition, and iii) biocontrol of List. monocytogenes ATCC 15313 with Leuc. citreum MB1 during growth in milk at refrigeration temperature. According to our results, it is unquestionable that at least one bacteriocin is active in Leuc. citreum MB1, since important antilisterial activity was verified either in its cell-free supernatant or in co-culture experiments. Co-culture tests showed that ~107 CFU\/ml Leuc. citreum MB1 was the optimal initial concentration to obtain maximum pathogen inhibition. Moreover, Leuc. citreum MB1 was able to delay List. monocytogenes growth at refrigerated temperature.","palabras_clave":"LEUCONOSTOC|BACTERIOCIN|ANTILISTERIAL ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38484,"idioma_id":4,"titulo":"FTIR spectroscopic metabolome analysis of lyophilized and fresh Saccharomyces cerevisiae yeast cells","resumen":"The yeast Saccharomyces cerevisiae is widely used as a biological eukaryotic model and also serves as a biotechnology production organism. One of the methods used to avoid degradation of the yeast cells content is lyophilisation. The use of lyophilized yeast cells has several advantages over fresh ones: samples can be easily transported and\/or stored and variations of their metabolomic profiles do not occur during transport or storage. Fourier transform infrared (FTIR) spectroscopy is one of the most emerging approaches in modern biology that permits to operate on very small quantities of whole cells without the need of extractions or purifications. This technique is very sensitive and not only allows the discrimination between different cell genotypes but also between different growth conditions. FTIR spectra provide interesting data on the metabolic status of the whole cell. Modern multivariate data processing was applied to analyse live fresh or lyophilized S. cerevisiae cells from different growth media. This study clearly demonstrate that yeast cells coming from an identical biological medium can be used indiscriminately for FTIR analysis whether they are analysed directly as live fresh cells or after lyophilization which is a freeze-drying process. Moreover, FTIR data obtained using lyophilized cells showed less variability.","palabras_clave":"YEAST|FTIR|FREEZE DRYING|PLS-DA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38485,"idioma_id":4,"titulo":"Organic farming fosters agroecosystem functioning in Argentinian temperate soils: evidence from litter decomposition and soil fauna.","resumen":"Benefits of organic farming on soil fauna have been widely observed and this has led to consider organic farming as a potential approach to reduce the environmental impact of conventional agriculture. How-ever, there is still little evidence from field conditions about direct benefits of organic agriculture on soil ecosystem functioning. Hence, the aims of this study were to compare the effect of organic farming versus conventional farming on litter decomposition and to study how this process is affected by soil meso- and macrofauna abundances. Systems studied were: (1) organic farming with conventional tillage (ORG), (2)conventional farming with conventional tillage (CT), (3) conventional farming under no-tillage (NT), and(4) natural grassland as control system (GR). Decomposition was determined under field conditions by measuring weight loss in litterbags. Soil meso- and macrofauna contribution on decomposition was evaluated both by different mesh sizes and by assessing their abundances in the soil. Litter decomposition was always significantly higher after 9 and 12 months in ORG than in CT and NT (from 2 to 5 times in aver-age), regardless decomposer community composition and litter type. Besides, mesofauna, macrofauna and earthworm abundances were significantly higher in ORG than in NT and CT (from 1.6 to 3.8, 1.7 to 2.3and 16 to 25 times in average, respectively for each group). These results are especially relevant firstly because the positive effect of ORG in a key soil process has been proved under field conditions, being the first direct evidence that organic farming enhances the decomposition process. And secondly because the extensive organic system analyzed here did not include several practices which have been recognized as particularly positive for soil biota (e.g. manure use, low tillage intensity and high crop diversity). So, this research suggests that even when those practices are not applied, the non-use of agrochemicals is enough to produce positive changes in soil fauna and so in decomposition dynamics. Therefore, the adoption of organic system in an extensive way can also be suggested to farmers in order to improve ecosystem functioning and consequently to achieve better soil conditions for crop production.","palabras_clave":"ECOSYSTEM SERVICES|ORGANIC AGRICULTURE|CONVENTIONAL AGRICULTURE|LITTER DECOMPOSITION|SOIL MACROFAUNA|SOIL MESOFAUNA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38486,"idioma_id":4,"titulo":"Green Synthesis of ZSM-5 Zeolite Prepared by Hydrothermal Treatment of Perlite. Effect of Chemical Composition and Characterization of the Product","resumen":"We studied the influence of the chemical composition of the starting synthesis gel (SiO2\/Al2O3, H2O\/SiO2, amount of seed and pH) on the preparation of ZSM-5 zeolite by hydrothermal treatment of expanded perlite.Gels with molar compositions of SiO2\/Al2O3 = 20?55 and H2O\/SiO2= 25?45, formed at pH values varying from 10.1 to 10.5, produced ZSM-5 zeolite, crystallizing at 453 K for 24 h in a seeded system. Compared with the conventional autoclave treatment, this method avoids the use of environmental-toxic organic structure directing agents. The highly crystalline ZSM-5 zeolite obtained was characterized employing a variety of analytical techniques, including X-ray powder diffraction, scanning electron microscopy, nitrogen adsorption-desorption isotherms, Fourier transform infrared spectroscopy (FTIR), infrared studies of pyridine sorption, 27Al MAS NMR,29Si MAS NMR and thermogravimetric analysis. At pH values of 13.0 and 13.3, the MFI phase changed to Phillipsite and Analcime, with intermediate formation of amorphous phase at pH 12.0, rearranging the 5?5?1 elements into S4R and S6R units. It was found that the use of an amorphous and low-cost silicoaluminate as starting material can lead, through an inexpensive methodology, to a highly valuable microporous material with many potential applications.","palabras_clave":"Molecular Sieves|Zeolites|ZSM-5|Expanded Perlite|Hydrothermal Treatment."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38487,"idioma_id":4,"titulo":"Incorporation of Lactobacillus delbrueckii subsp lactis (CIDCA 133) in cold-set gels made from high pressure treated soybean proteins","resumen":"The ability of freeze-dried high pressure-treated soybean proteins to form cold-set gels and their aptitudeto act as a protective matrix to Lactobacillus delbrueckii subsp lactis strain CIDCA 133 were evaluated.Gels were obtained by dispersing denatured soybean protein isolates (SPI) in water or in a lactobacillisuspensions, and further incorporation of calcium. When SPI were dispersed in water, ordered, adhesive,and with high water holding capacity gels were obtained at a calcium concentration of 0.015 mol L1.Increase in calcium concentration to 0.020 mol L1 increased elastic modulus (small deformationrheology) and maximum force (texture profile) and made gels become opaque. When protein concentrationwas90 g L1, and denaturation of SPI was carried out at 600 MPa gels with higher values of elasticmodulus were obtained as compared with those from gels denatured at 400 MPa. After dispersing denaturedSPI in lactobacillus suspensions the gels were turbid and with a pink-like color. Elastic modulusand tan d of gels prepared in lactobacilli suspensions were higher than those dispersed in water,revealing that matrix was modified by lactobacilli presence. The lactobacilli included in these cold-setgels survived better than in coagulated milk to a modeled gastric challenge. Moreover, bacteriaremained viable without damaging the matrix during a 28-days storage at 4 C. The high soybean proteinconcentration would be responsible for lactobacilli protection. Our results suggest that SPI cold-set gelsmay be used as carriers for lactobacilli protecting them from the effect of simulated gastric juice andenabling their incorporation in functional foods.","palabras_clave":"Lactobacillus|cold-set gels|soybean proteins"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38488,"idioma_id":4,"titulo":"Self assembly of the second-generation of nitroaryl-ended dendrons onto carbon","resumen":"We report theself-assembly of the second-generation of nitroaryl-ended dendrons onto carbonsurfaces. Theimmobilized layer was characterized by cyclic voltammetry (CV)electrochemical impedance spectroscopy and atomic force microscopy (AFM). Theresponse was analyzed in comparison to the first-generation dendronbehavior. Reductionof both layers generates the hydroxylamine product. The resulting redox-activelayer exhibits a well-behaved redox response for the adsorbednitroso\/hydroxylamine couple. The thermodynamic of theadsorption of both dendrons on glassy carbon electrodes was also studied by CV.The Frumkin adsorption isotherm was the best to describe the speci&#64257;cinteractions. The AFM images showed a network film formation with embeddedaggregates that completely covered the carbon surface. The average heightsuggests a tilted preferential adsorption for both molecules.","palabras_clave":"second-generation dendron|self-assembly|dendronized electrodes|Frumkin adsorption"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38489,"idioma_id":4,"titulo":"Effect of carbonylcyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) on the interaction of 1-anilino-8-naphthalene sulfonate (ANS) with phosphatidylcholine liposomes","resumen":"The weak hydrophobic acid carbonylcyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) is a  protonophoric uncoupler of oxidative phosphorylation in mitochondria. It dissipates the electrochemical  proton gradient (ÄìH  +) increasing the mitochondrial oxygen consumption. However, at concentrations higher  than 1 ìM it exhibits additional effects on mitochondrial energy metabolism, which were tentatively related to  modifications of electrical properties of the membrane. Here we describe the effect of FCCP on the binding of  1-anilino-8-naphthalene sulfonate (ANS) to 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-  dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) unilamellar vesicles. FCCP inhibited the binding of ANS to  liposomes either in the gel or in the liquid crystalline phase, by increasing the apparent dissociation constant  of ANS. Smaller effect on the dissociation constant was observed at high ionic strength, suggesting that the  effect of FCCP is through modification of the electrostatic properties of the membrane interface. In addition,  FCCP also decreased (approximately 50 %) the quantum yield and increased the intrinsic dissociation  constant of membrane-bound ANS, results that suggest that FCCP makes the environment of the ANS  binding sites more polar. On those grounds we postulate that the binding of FCCP: i) increases the density of  negative charges in the membrane surface; and ii) distorts the phospholipid bilayer, increasing the mobility of  the polar headgroups making the ANS binding site more accessible to water.","palabras_clave":"ANS binding|FCCP|Surface potential|Liposomes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38490,"idioma_id":4,"titulo":"Early to Middle Holocene transition in the Pastos Chicos record, dry Puna of Argentina","resumen":"This paper presents a multi-proxy record and its paleoenvironmental interpretation from Pastos Chicos  (23 400 2900 S; 66 250 3200 W; 3781 m asl), Susques, Jujuy province, Argentina. The analysis includes  a study of fluvial sediments and geomorphology, and the contained diatoms and pollen record at  centenary resolution. Two main environmental phases characterize the 9000e4200 BP interval. The  first phase was a humid period between 9000 and 7300 BP (circa 10,000e8100 cal. BP) which showed  organic soils formation in a floodplain broadly vegetated by grasses with a high and stable water table  level. The second phase developed between 7300 and 6000 BP (w8100e6800 cal. BP) and showed  a moderately drier environment interrupted by punctuated humid events such as those around 7000 and  6300 BP. This environment could be interpreted as a permanently existing meandering river with  a floodplain with shallow oxbow lakes, bordered by a diverse shrub steppe. After 6000 BP, the fluvial  system turned into a braided river situated in a sandy floodplain with dunes and ephemeral ponds. At the  end of the sequence (i.e. post 4200 BP), salt crusts developed and the river lowered its base level by  8 m. These results seem to show that the Pastos Chicos river basin evolved from low energy and more  humid conditions established during the Early and the first part of the Middle Holocene, to drier ones in  a system with more energy during some events of the second part of the latter period. The start of this  aridization process at 6000 BP in the basin, seems to be substantially later than other observations in  local records of the Andean area. This could be due to physiographic control of the moisture by the  catchment area (1000 km2) that generates a catchment-averaged regional scale signal of smaller  amplitude, which is delayed for individual tributaries. These studies, with other ongoing analysis, will  improve the accuracy of the models of resource structure in the area in several spaceetime scales and,  consequently, advance knowledge concerning the organizational pattern of human societies in the past.","palabras_clave":"Paleoambiente|Puna de Jujuy|Holoceno|Arqueología"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38491,"idioma_id":4,"titulo":"Cytoprotective mechanisms in rats lung parenchyma with zinc deprivation","resumen":"Suboptimal intake of Zinc (Zn) is one of  the most common worldwide nutritional problems.  The aim of this study is to provide new evidence on the  relation between moderate Zn restriction, and cytoprotective  functions in airway epithelium. We analyzed  the effect of moderate Zn deficiency (ZD) on the  expression of several pro and anti-apoptotic proteins  and cytoprotective factors (Hsp27 and Hsp 70i), as  well as the effect of restoring Zn during the refeeding  period. Adult male rats were divided into three groups:  Zn-adequate control group, Zn-deficient group and  Zn-refed group. Our previous findings showed an  important oxidative and nitrosative stress during ZD,  this situation is accompanied by inflammation and  alterations in the expression of matrix extracellular  proteins. We observed a strong immunopositive area  of anti and pro-apoptotics proteins in ZD groups.  The mRNA levels of Nrf-2, Bax and Bad were  increased in ZD, while in ZD refed group its levels  were similar to the control values. The increased  expression of Nrf-2 is likely to be critical for  protection of lung under inflammatory process triggered  during ZD. Hsp27 and Hsp 70i showed an  increase of immunostaining area but they were not  significant. During the supplementation period, heatshock  proteins increased significantly. In conclusion,  our results provide further evidence of the pathways  involved in cytoprotection and apoptosis caused by  ZD. Additional studies are required in order to  investigate whether Hsp27 and Hsp70 are consistently  associated with cellular stress and inflammation in  lung. There may be a beneficial role for improved Zn  nutrition or Zn supplements early in lung pathology.","palabras_clave":"CELL STRESS|HEAT SHOCK PROTEINS|ZINC|CYTOPROTECTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38492,"idioma_id":4,"titulo":"Restoration of high altitude forests in an area affected by a wildfire: Polylepis australis Bitt. seedlings performance after soil inoculation","resumen":"Polylepis forests are one of the most endangered high mountain ecosystems of South America and reforestation with native Polylepis species has been recommended. To determine whether native soil inoculation could help in reforestation success, a field trial was set up to evaluate the response of outplanted P. australis seedlings to the inoculation with soils from three vegetation types (a grassland, a mature forest and a degraded forest) and a sterile soil, used as control. We evaluated seedlings performance: growth and survival for 18 months, root\/shoot ratio, phosphorous content and arbuscular mycorrhizal fungal (AMF) colonization. To interpret performance patterns we evaluated the colonization potential of the three inoculum soils and the changes of the AMF community composition of the seedlings rhizosphere in relation to inoculation treatment and season. Our main results showed no significant differences in seedlings survival and growth between treatments. The colonization potential of grassland and degraded forest soils was approximately 25 times greater than mature forest soil and specific spore density of some morphospecies varied with season. However, AMF spore community of seedlings rhizosphere became homogenized after outplanting and was similar between treatments after 12 months. Therefore, we conclude that soil inoculation was not essential for outplanted P. australis survival and increase in height, and thus all the tested soils could be used as inocula, including grassland soils which in practice are the easiest to collect.","palabras_clave":"MOUNTAIN FOREST|REFORESTATION|PERFORMANCE|NATURAL SOIL INOCULA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38493,"idioma_id":4,"titulo":"STABILITY OF FREEZE-DRIED LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS IN THE PRESENCE OF GALACTO-OLIGOSACCHARIDES AND LACTULOSE AS DETERMINED BY NEAR INFRARED SPECTROSCOPY","resumen":"The ability of two types of galacto-oligosaccharides (GOS) and lactulose to protect Lactobacillus delbrueckii subsp. bulgaricus upon freeze-drying was evaluated on the bases of their capacity to form glassy structures, using Near Infrared Spectroscopy (NIRS).  After freeze-drying in the presence of cryoprotectants, microorganisms were stored at 4 oC at different relative humidities (RH) (from 11 to 80 %) up to 21 days. The loss of viability was determined by plate count and referred to viability before freeze-drying. For each storage condition, vitreous transition temperatures (Tg) were determined by differential scanning calorimetry (DSC). In parallel, near infrared (NIR) spectra registered in the 900-1700 nm region provided information regarding viability and RHs that could be correlated with the results obtained from plate counts and DSC.  The comparison of NIR spectra of freeze-dried samples stored at the same RH but differing in the time of storage allowed the identification of spectral features related with viability.  The spectral differences observed on samples stored in the same conditions (same time of storage and same cryoprotectant), but differing in RHs, were related with the amorphous and rubbery states.  Based on the spectral information, a multivariate based classification model (PLS-DA) was defined to determine whether samples are in a rubbery or an amorphous state. The accuracy of the defined model supports the use of NIRS to classify the correct storage of unknown freeze-dried samples in a short time-consuming procedure. As the only information required is that contained in the NIR spectra, this model may result in a useful method at an industrial level, where the save of time is much appreciated.","palabras_clave":"L. bulgaricus|NIR|freeze-drying"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38494,"idioma_id":4,"titulo":"Characterization and bacterial adhesion of chitosan-perfluorinatedacid films","resumen":"tWe reported herein the study and characterization of films obtained by casting of chitosan solutionsin perfluorinated acids, trifluoroacetic (TFA), perfluoropropionic (PFPA), and perfluorooctanoic (PFOA).The films were characterized by FTIR, solid state13C NMR, X-ray, AFM, contact angle, thermogravimetriceffluent analysis by mass spectrometry, and rheology. The results showed a marked influence of chainlength of the perfluorinated acids on the hydrophobic\/hydrophilic ratio of the modified chitosan filmswhich was evidenced by the different characteristics observed.The material that showed greater surface stability was chitosan-PFOA. Chitosan film with the additionof PFOA modifier became more hydrophobic, thus water vapor permeability diminished compared tochitosan films alone, this new material also depicted bacterial adhesion which, together with the featuresalready described, proves its potential in applications for bioreactor coating.","palabras_clave":"CHITOSAN|PERFLUORINATE ACIDS|THERMAL DEGRADATION|RHEOLOGY|MICROBIOLOGICAL  ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38495,"idioma_id":4,"titulo":"Effect of ethylcellulose on the structure and stability of non-aqueous oil based propylene glycol emulsions","resumen":"The hydrophobic polymer ethylcellulose (EC) has been used to structure vegetable oils and  as stabilizer of oil\/water (o\/w) emulsions, among other non food uses. In this work we show that EC  dissolved in medium chain triglycerides (MCT) or soybean oil (SO) is able to stabilize non-aqueous  emulsions of propylene glycol (PG) as dispersed phase. Cream-like emulsions can be obtained at low  and high homogenization speeds which show a very good stability for at least one month without the  requirement of co-surfactants. PG-in-oil emulsions at concentrations of EC below 5 % (w\/w) have  pseudoplastic behavior and greater viscosity than the respective solutions of the polymer in MCT or  SO. However, at concentrations of EC above 5 % (w\/w) firm gels are formed in MCT or SO and after the  addition of PG, the emulsions formed have lower viscosity than the original solutions of the polymer in  MCT or SO. Such effects were independent on the mean molecular weight (MMW) of the EC at high  shear stress and inversely proportional at low shear stress. These results indicate that the stabilizing  effect of EC in PG-in-oil emulsions might not be due mainly to an increase in viscosity of the continuous  phase. Comparing all the results obtained, we can infer that EC, despite being insoluble in PG, is  promoting interactions which are responsible of the observed effects.  These PG-in-oil emulsions have interesting structural and flow properties which make them attractive  to be used in food formulations, either as emulsions themselves or as potential vehicles for active  ingredients.","palabras_clave":"ETHEYLCELLULOSE |NON-AQUEOUS EMULSION|OLEOGELS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38496,"idioma_id":4,"titulo":"Opioid modulation of prolactin secretion induced by stress during late pregnancy. Role of ovarian steroids","resumen":"OPIOID MODULATION OF PROLACTIN SECRETION INDUCED BY STRESS DURING LATE PREGNANCY. ROLE OF OVARIAN STEROIDSAbstractBackground:&nbsp; The opioid system modulates prolactin release during late pregnancy. Its role and the participation of ovarian hormones in this modulation are explored in ether stress-induced prolactin release. Methods\/Results: Estrous, 3-day and 19-day pregnant rats were used. We administered the antagonist mifepristone (Mp) and tamoxifen to evaluate progesterone and estradiol action in naloxone (NAL, opioid antagonist) or saline treated rats. Ether stress had no effect on serum prolactin levels in controls but increased prolactin release in NAL-treated rats. Prolactin response to stress in NAL-treated rats was blocked by L-DOPA administration. Mp treatment on day 18 of pregnancy increased prolactin levels after stress without alterations by NAL. Tamoxifen on days 14 and 15 of pregnancy completely blocked Mp and NAL effects on prolactin release at late pregnancy. In contrast, stress significantly increased prolactin levels in estrous rats and pretreatment with NAL prevented this. On day 3 of pregnancy, at 06.00 p.m., stress and NAL treatment inhibited prolactin levels in saline-treated rat. No effect of stress or NAL administration was detected on day 3 of pregnancy at 09.00 a.m. I.c.v. administration of specific opioids antagonist, B-Funaltrexamine but not Nor-Binaltorphimine or Naltrindole, caused a significant increase in stress-induced prolactin release.Conclusions: Opioid system suppression of prolactin stress response during late pregnancy was observed only after progesterone withdrawal, involving a different opioid mechanism from its well-established stimulatory role. This mechanism acts through a mu opioid receptor and requires estrogen participation. The opioid system and progesterone may modulate stress-induced prolactin release, probably involving a putative prolactin-releasing factor.","palabras_clave":"PROLACTIN|STRESS|MIFEPRISTONE|NALOXONE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38497,"idioma_id":4,"titulo":"Physiopathological effects of Escherichia coli O157:H7 inoculation in weaned calves fed with colostrum containing antibodies to EspB and Intimin.","resumen":"Escherichia coli O157:H7 is responsible for severe intestinal disease and hemolytic uremic syndrome (HUS), a serious systemic complication which particularly affects children. Cattle are the primary reservoir for E. coli O157:H7 and the main source of infection for humans. In this study, we evaluated the ability of transferred maternal colostral antibodies against &#947;-Intimin C280 and EspB, to protect young weaned calves from E. coli O157:H7 infection. Hyperimmune colostra were obtained by immunization of pregnant cows with a mix of the mentioned antigens. All vaccinated cows mounted a significant IgG response against &#947;-Intimin C280, and EspB in sera and colostra. Colostrum-fed calves also exhibited high serum IgG titers against &#947;-Intimin C280 and EspB along with a rise in mucosal &#947;-Intimin C280-specific IgG antibodies at recto-anal junction and ileum. Additionally, 70 day-old calves received a challenge with E. coli O157:H7 but no reduction in total bacterial shedding or frequency of E. coli O157:H7 excretion from these calves was observed. Most tissue samples showed granulocyte focal infiltrations of the lamina propria and enterocyte erosion. In conclusion, up to the 70th day, the passively acquired &#947;-Intimin-C280 and EspB-IgG antibodies present in sera and recto-anal mucosa reached a titer insufficient to reduce EHEC O157 shedding and damages of experimentally inoculated young calves.","palabras_clave":"CALVES|COLOSTRUM|EHEC O157:H7|IGG|VACCINE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38498,"idioma_id":4,"titulo":"EFFECTS OF PYRUVATE ON THE ENERGETICS OF  RAT VENTRICLES STUNNED BY  ISCHEMIA-REPERFUSION","resumen":"ABSTRACT: Pyruvate (Pyr) was proposed as an additive to cold high-K+?low-Ca2+ cardioplegia (CPG) to protect the heart during surgery. We explored whether Pyr and CPG would work synergistically to protect rat hearts from stunning during ischemia? reperfusion (I\/R). We measured the heat release and contractility of perfused ventricles during I\/R, and the cytosolic and mitochondrial [Ca2+] in cardiomyocytes. We found that under cold-CPG (30 °C), 10 mmol?L&#8722;1 Pyr reduced the post-ischemic contractile recovery (PICR) as well as muscle economy, when added either before I or during I\/R, which was reversed by blockade of UCam. In noncardioplegic hearts, Pyr was cardioprotective when it was present during I\/R, more so at 37 °C than at 30 °C, with improved economy. In cardiomyocytes, the addition of Pyr to CPG slightly increased the mitochondrial [Ca2+] but decreased cytosolic [Ca2+]. The results suggest that Pyr only protects hearts from stunning when present before ischemia and during reperfusion, and that it dampens the cardioprotective properties of CPG. The mechanisms underlying such different behavior depend on the dynamic balance between Pyr stimulation of the energetic state and mitochondrial Ca2+ uptake. Our results support the use of Pyr in stunned hearts, but not in cold high-K+ cardioplegia.","palabras_clave":"PYRUVATE|HEART|ISCHEMIA-REPEFUSION|CARDIOPLEGIA|CALORIMETRY|CA2+"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38499,"idioma_id":4,"titulo":"Evaluation of Urinary N-Acetyl-beta-D-Glucosaminidase as a marker of early renal damage in patients with type 2 Diabetes Mellitus","resumen":"Objective: To evaluate the clinicalusefulness of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion for thedetection of early tubular damage in type 2 diabetes mellitus (T2DM). Subjects and methods: Thirty sixpatients with T2DM were divided into two groups based on urinary albumin tocreatinine ratio (ACR): normoalbuminuria (ACR &lt;30 mg\/g; n=19) andmicroalbuminuria (ACR= 30-300 mg\/g; n=17). The following parameters were determinedin both groups: urinary NAG and albumin, serum and urine creatinine, fastingplasma glucose and glycated hemoglobin (HbA1c). Results: Urinary NAG levels [Units\/g creatinine; median (range)] weresignificantly increased in microalbuminuria group [17.0 (5.9 - 23.3)] compared tonormoalbuminuria group [4.4 (1.5 - 9.2)] (P&lt;0.001). No differences betweengroups were observed in fasting glucose, HbA1c and serum creatininelevels. Urinary NAG positively correlated with ACR (r= 0.628; P&lt;0.0001),while no significant association was observed between NAG and glycemia, HbA1c&nbsp; and serum creatinine. Conclusions: The increase of urinaryNAG at the microalbuminuria stage of diabetic nephropathy (DN) suggest thattubular dysfunction is already present in this period. The significant positiveassociation between urinary NAG excretion and ACR indicates the possibleclinical application of urinary NAG as a complementary marker for earlydetection of DN in T2DM. ","palabras_clave":"URINARY n-ACETYL-BETA-D-GLU8COSAMINIDASE|EARLEY TUBULAR DAMAGE|TIYPE 2 DIABETES MELLITUS|MICROALBUMINURIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38500,"idioma_id":4,"titulo":"HARD SURFACES DECONTAMINATION OF ENTEROPATHOGENIC AND SHIGA TOXIN-PRODUCING Escherichia coli USING BACTERIOPHAGES","resumen":"Three Myoviridae phages (DT1, DT5 and DT6) specific for pathogenic Escherichia coli were studied, either individually or as cocktails, for their lytic activity on in vitro challenge tests. Also, cocktail ability to reduce artificial contamination on hard surfaces (glass coverslips and stainless steel coupons) by three pathogenic Escherichia coli strains (EPEC920, non-O157 STEC ARG4827 and O157:H7 STEC464) was tested. Assays of phage stability during refrigerated storage showed that the three phages evaluated retained a high viability after two months at 4 °C. Challenge tests showed high reductions in viable cells, of up to 6.4 log CFU ml&#8722;1, for all tested strains at 37 °C. Efficiency was somewhat lower at 4 °C, though biocontrol levels were still good, reaching values of up to 3.8 log CFU ml&#8722;1. Considering only results obtained at 37 °C, phage cocktails produced the highest reduction in most cases. Treatments with phage cocktails produced complete inactivation (ca. 5?6 log CFU ml&#8722;1) of EPEC920 and O157:H7 STEC464 on glass coverslips, and of EPEC920, non-O157 STEC ARG4827 and O157:H7 STEC464 on stainless steel coupons, at both temperatures (4 °C and 37 °C) and multiplicity of infection (ca. 103 and 107) tested. However, some strains not detected at 3 h were sometimes detected at 24 h, and inactivation of non-O157 STEC ARG4827 on glass coverslips was never accomplished; viable cell reductions in all these cases ranged from 1.2 to 5.4 log CFU ml&#8722;1. Our results suggest that lytic phages, either individually or as a cocktail, may be useful for reducing contamination on hard materials used in food processing surfaces. To our knowledge, this is the first study focused on the use of bacteriophages to reduce contamination of food processing surfaces by EPEC and non-O157 STEC strains.","palabras_clave":"Escherichia coli|Bacteriophage|Hard surface|Decontamination"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38501,"idioma_id":4,"titulo":"Macromolecular oxidation in planktonic population and biofilms of Proteus mirabilis exposed to ciprofloxacin","resumen":"Abstract Diverse chemical and physical agents can alter  cellular functions associated with the oxidative metabolism,  thus stimulating the production of reactive oxygen  species (ROS). Proteins and lipids may be important targets  of oxidation, and this may alter their functions in planktonic  bacterial physiology. However, more research is  necessary to determine the precise role of cellular stress  and macromolecular oxidation in biofilms. The present  study was designed to evaluate whether ciprofloxacin (CIP)  could oxidize the lipids to malondialdehyde (MDA) and  the proteins to carbonyl residues and to advanced oxidation  protein products (AOPP) in planktonic populations and  biofilms of Proteus mirabilis. Incubation with CIP generated  an increase of lipid and protein oxidation in planktonic  cells, with a greater effect found in sensitive strains than  resistant ones. Biofilms showed higher basal levels of  oxidized macromolecules than planktonic bacteria, but  there was no significant enhancement of MDA, carbonyl,  or AOPP with antibiotic. The results described in this  article show the high basal levels of MDA, carbonyls, and  AOPP, with aging and loss of proliferation of biofilms  cells. The low response to the oxidative stress generated by  CIP in biofilms helps to clarify the resistance to antibiotics  of P. mirabilis when adhered to surfaces.","palabras_clave":"OXIDATION|BIOFILM|PLANTONIC|MACROMOLECULES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38502,"idioma_id":4,"titulo":"Removal of humic acid by organo-montmorillonites: Influence of surfactant loading and chain length of alkylammonium cations","resumen":"In this study, the characterization and adsorption  properties of montmorillonite (MMT) and  organomontmorillonites with different surfactant\/  cationic exchange capacity (CEC) ratios (1 and 2) of  tetradecyl trimethylammonium (TDTMA+) and  hexadecyl trimethylammonium (HDTMA+) cations were  evaluated. The particle apparent diameter, determined by  laser and scanning electron microscopy showed aggregate  formation, which varied with loading and cation  length of the surfactant used. X-ray diffraction analysis  revealed the formation of a pseudotrilayer arrangement of  both surfactants in the interlayer space, FTIR showed the  characteristic bands of the surfactants and micelle formations,  and zeta potential determinations indicated neutral  or negative surface charge values, except for sample  obtained with one CEC concentration exchanged with  HDTMA+ (HDTMA1-MMT) where a charge reversal to  positive was found. Higher adsorption amounts of humic  acid (HA) were found for HDTMA1-MMT and  TDTMA1-MMT samples than for MMT sample, while  the increase in the loading of both surfactants decreased  the amounts of HA adsorbed could be assigned to a  higher micelle formation and different packing density  of alkyl chain, in the external surface. The correlation  found between the total surface area and negative zeta  potential values and the HA adsorption rate, within each  surfactant, indicated the strong influence that these properties  have on HA adsorption.","palabras_clave":"Humic acid|Organo-montmorillonites|HDTMA+ surfactants|TDTMA+ surfactants"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38503,"idioma_id":4,"titulo":"Matrix Photochemical Study and Conformational Analysis of CH3C(O)NCS and CF3C(O)NCS","resumen":"ABSTRACT: The vapor of acetyl isocyanide, CH3C(O)NCS, and tri&#64258;uoroacetyl isocyanide, CF3C(O)NCS, were isolated in solid Ar at 15 K. The existence of rotational isomerism was  con&#64257;rmed when the matrixes were irradiated with broad-band UV&#8722;vis light (200 &#8804; &#955; &#8804; 800 nm) and also by temperature dependent Ar-matrix IR spectroscopy. The initial spectra showed the vapor of CH3C(O)NCS and CF3C(O)NCS consist of two conformers syn&#8722;syn and syn&#8722;anti (with the C=O bond syn with respect to the C&#8722;H or C&#8722;F bond and syn or anti with respect to the N=C double bond). When CH3C(O)NCS is irradiated, simultaneously with the randomization process, H2CCO and HSCN are produced. In the case of the photolysis of CF3C(O)NCS, the main products are CF3NCS and CO.  The assignment of the IR bands to the di&#64256;erent photoproducts was made on the basis of the usual criteria, taking account reported antecedents in the literature.","palabras_clave":"Photochemistry|Quantum Chemical Calculations|Conformational Analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38504,"idioma_id":4,"titulo":"Rheological properties of bread dough formulated with wheat flour organic calcium salts-FOS enriched inulin systems.","resumen":"The objective of this work was to study the effect oforganic calcium salts?fructooligosaccharide (FOS)-enrichedinulin systems on dough structure and rheological propertiesof wheat flour dough. Wheat flour was enriched with calciumlactate (CaLa2) or calcium citrate (Ca3Ci2) (from 1,080 to2,520 ppm Ca) and FOS-enriched inulin (In) (from 0 to13 %, w\/w flour basis). Alveographic, texture, relaxation,and viscoelasticity properties of dough were analyzed. Wetand dry gluten quantity, related to scanning electron microscopystructure, was also determined. Tenacity, extensibility,and deformation energy of dough decreased with the incrementof In content. When CaLa2 was employed, they changedmainly with fiber, hiding the effect of lactate; whereas withCa3Ci2, these parameters were not only affected by the fiber, but also by the salt. At In 6.5 %, high calcium content (2,520 ppm Ca) produces an increase in hardness and a decrease in cohesiveness for citrate ion; the opposite effect was detected with lactate ion. These parameters decreased at high content of In (13 %). Adhesiveness was dependent only on In level; more adhesive dough at In&gt;6.5 % were obtained, mainly in the case of CaLa2. Ca3Ci2 prevents the decrease in adhesiveness at In&gt;12 %. At high calcium levels, high In produced more elastic dough only in the presence of citrate; for lactate, the predominant factor was In. Lactate anion destabilizes protein structure, and together with In favors formation of a less elastic gluten network. On the other hand, the stabilizing effect of citrate ion in a firm network was enhanced by FOS-enriched inulin.","palabras_clave":"calcium lactate|calcium citrate|fructo-oligosaccharides \/inulin|wheat flour|dough rheology."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38505,"idioma_id":4,"titulo":"Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia: Involvement of mitochondrial aquaporin-8","resumen":"We recently reported that hepatocyte mitochondrial aquaporin-8 (mtAQP8) channels facilitate the uptake of ammonia and its metabolism into urea. Here we studied the effect of bacterial lipopolysaccharides LPS) on ammonia-derived ureagenesis. In LPS-treated rats, hepatic mtAQP8 protein expression and diffusional ammonia permeability (measured utilizing ammonia analogues) of liver inner mitochondrial membranes were downregulated. NMR studies using 15 N-labeled ammonia indicated that basal and glucagon-induced ureagenesis from ammonia were significantly reduced in hepatocytes from LPS-treated rats. Our data suggest that hepatocyte mtAQP8-mediated ammonia removal via ureagenesis is impaired by LPS, a mechanism potentially relevant to the molecular pathogenesis of defective hepatic ammonia detoxification in sepsis.","palabras_clave":"LIPOPOLYSACCHARIDE|UREA SYNTHESIS|MITOCHONDRIAL AMMONIA TRANSPORT|AQUAPORIN 8"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38506,"idioma_id":5,"titulo":"Determinacion de tensiones residuales en válvulas de motores de combustión interna","resumen":"Los gradientes térmicos que se  presentan durante el servicio de ciertos componentes de máquinas térmicas  alcanzan en ocasiones magnitud suficiente como para generar deformaciones  inelásticas que influyen sobre el estado tensional en condiciones de servicio,  y se manifiestan como tensiones residuales al enfriar las piezas hasta  temperatura ambiente.      Una situación similar se  presenta en piezas que son sometidas a tratamientos térmicos o fusión y  solidificación localizados, tales como soldadura, aportes de metal fundido,  temple por inducción, etc.      Para determinar el estado  tensional efectivo y la aptitud de la pieza para el servicio, es imprescindible  conocer la magnitud de estas deformaciones inelásticas y sus tensiones  residuales asociadas.      Algunas de las técnicas  experimentales disponibles en la actualidad (Difracción de Rayos X o neutrones,  Ruido de Barkhäusen) solo brindan información respecto del estado tensional en  la superficie de las piezas. Otras, tales como las rosetas de galgas extensométricas,  no pueden ser aplicadas con precisión en piezas de forma complicada.       En este trabajo se presenta una  metodología de remoción de capas para determinar tensiones residuales en piezas  axisimétricas utilizando instrumental de metrología dimensional de uso  corriente en la industria de autopartes, en conjunto con técnicas de cálculo  numérico.   Como caso de aplicación, se describe el análisis de tensiones efectivas  durante el servicio de una válvula  de un  motor de combustión interna, evaluando previamente las tensiones residuales de  origen térmico","palabras_clave":"TENSION RESIDUAL|REMOCION CAPAS|DEFORMACION INELASTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38508,"idioma_id":4,"titulo":"Monocytes from Sjögren syndrome patients display increased VPAC2 expression and impaired apoptotic cell phagocytosis","resumen":"Sjögren´s syndrome (SS) is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction. Clinical observations and results from animal models of SS support the role of aberrant epithelial cell apoptosis and immune homeostasis loss in the glands as triggering factors for the autoimmune response. Vasoactive intestinal peptide promotes potent anti-inflammatory effects in several inflammatory and autoimmune disease models including the non obese diabetic (NOD) mouse model of SS. On the knowledge that VIP modulates monocyte function through VPAC receptors and that immune homeostasis maintenance strongly depends on a rapid and immunosuppressant apoptotic cell clearance by monocytes\/macrophages, here we explored VPAC expression on monocytes from primary SS (pSS) patients and the ability of VIP to modulate apoptotic cell phagocytic function and cytokine profile. Monocytes isolated from individual pSS patients showed an increased expression of VPAC2 subtype of VIP receptors, absent in monocytes from control subjects, with no changes in VPAC1 expression. VPAC2 receptor expression could be further induced with LPS in pSS monocytes and VIP inhibited the effect. Moreover, monocytes from pSS patients showed an impaired phagocytosis of apoptotic epithelial cells as evidenced by reduced engulfment ability and the failure to promote an immunosuppressant cytokine profile. However, VIP neither modulated monocyte\/macrophage phagocytic function nor did it reverse their inflammatory profile. We conclude that monocytes from pSS patients express high levels of VPAC2 and display a deficient clearance of apoptotic cells that is not modulated by VIP.","palabras_clave":"VPAC|MONOCYTES|SJOGREN'S SYNDROME"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38509,"idioma_id":4,"titulo":"Transcriptional regulators of legume-rhizobia symbiosis Nuclear Factors Ys and GRAS are two for tango","resumen":"Transcription factors are DNA binding proteins that regulate gene   expression. The nitrogen fixing symbiosis established between legume   plants and soil bacteria is a complex interaction, in which plants need   to integrate signals derived from the symbiont and the surrounding   environment to initiate the developmental program of nodule   organogenesis and the infection process. Several transcription factors   that play critical roles in these processes have been reported in the   past decade, including proteins of the GRAS and NF-Y families. Recently,   we reported the characterization of a new GRAS domain   containing-protein that interacts with a member of the C subunit of the   NF-Y family, which plays an important role in nodule development and the   progression of bacterial infection during the symbiotic interaction.   The connection between transcription factors of these families   highlights the significance of multimeric complexes in the fabulous   capacity of plants to integrate and respond to multiple environmental   stimuli.","palabras_clave":"root development|nitrogen fixation|nodulation|transcription factors"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38510,"idioma_id":4,"titulo":"A nuclear factor Y interacting protein of the GRAS family is required for nodule organogenesis, infection thread progression, and lateral root growth","resumen":"A C subunit of the heterotrimeric nuclear factor Y (NF-YC1) was shown to   play a key role in nodule organogenesis and bacterial infection during   the nitrogen fixing symbiosis established between common bean (Phaseolus   vulgaris) and Rhizobium etli. To identify other proteins involved in   this process, we used the yeast (Saccharomyces cerevisiae) two-hybrid   system to screen for NF-YC1-interacting proteins. One of the positive   clones encodes a member of the Phytochrome A Signal Transduction1   subfamily of GRAS   (for Gibberellic Acid-Insensitive (GAI), Repressor of GAI, and   Scarecrow) transcription factors. The protein, named Scarecrow-like13   Involved in Nodulation (SIN1), localizes both to the nucleus and the   cytoplasm, but in transgenic Nicotiana benthamiana cells, bimolecular   fluorescence complementation suggested that the interaction with NF-YC1   takes place predominantly in the nucleus. SIN1 is expressed in aerial   and root tissues, with higher levels in roots and nodules.   Posttranscriptional gene silencing of SIN1 using RNA interference (RNAi)   showed that the product of this gene is involved in lateral root   elongation. However, root cell organization, density of lateral roots,   and the length of root hairs were not affected by SIN1 RNAi. In   addition, the expression of the RNAi of SIN1 led to a marked reduction   in the number and size of nodules formed upon inoculation with R. etli   and affected the progression of infection threads toward the nodule   primordia. Expression of NF-YA1 and the G2\/M transition cell cycle genes   Cyclin B and Cell Division Cycle2 was reduced in SIN1 RNAi roots. These   data suggest that SIN1 plays a role in lateral root elongation and the   establishment of root symbiosis in common bean.","palabras_clave":"Gras transcription factor|common bean|Symbiosis|Rhizobium"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38511,"idioma_id":5,"titulo":"Estilos parentales en niños y niñas con TDAH","resumen":": Introducción: el Trastorno por Déficit de Atención e Hiperactividad   (TDAH) es una de las alteraciones neuroconductuales más frecuentes en la infancia. La   disfuncionalidad familiar es una variable de riesgo sobre la evolución de los síntomas. El objetivo   fue analizar y comparar los estilos parentales en niños con y sin TDAH. Metodología: diseño expo   facto con dos grupos, uno cuasi control. Se aplicaron dos escalas que evalúan estilos parentales.   Resultados: tanto los niños con TDAH como sus padres perciben al estilo parental más rígido e   indulgente y menos inductivo, caracterizado por una tendencia a manifestar mayor crítica y menor   aceptación y afectuosidad por parte de los padres. Conclusiones: los hallazgos permiten el desarrollo   de técnicas efectivas de disciplina y comunicación en la intervención clínica con familias de niños   con TDAH","palabras_clave":"trastornos de la atención|niños|TDAH|estilos parentales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38513,"idioma_id":4,"titulo":"HISTOLOGY OF THE OVARY OF CHINCHILLA LANIGERA IN CAPTIVITY","resumen":"Chinchilla, the lanigera variety in particular, is one of the most valuable rodents in the fur industry. The chinchilla ovary is morphologically similar to that of other South American hystricognath rodents, especially as regards its anatomy and, to a lesser degree, its histology.The presence of numerous primary follicles throughout the annual cycle suggests that a few of them are recruited to initiate growth and differentiation during folliculogenesis. Primary follicles with two or more oocytes are common; this is not the case with follicles at more advanced stages, suggesting that they do not develop.Only one or two large corpora lutea (CL) and three to five small or accessories CL were observed but no corpora albicans. The presence of accessory CL may reflect the importance of continuous hormonal production to support prolonged gestation. Atretic CL were also present, showing signs of degeneration in luteal cells. The interstitial cells distributed throughout the cortex were the main histological feature shared with other species, as stated in previous reports. Antral atresia was observed in all sizes of antral follicles while basal atresia was confined exclusively to smaller follicles.","palabras_clave":"OVARY|HISTOLOGY|CHINCHILLA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38514,"idioma_id":4,"titulo":"EFFECT OF DIFFERENT TYPES OF SESQUITERPENE LACTONES ON THE MATURATION OF Rhinella arenarum OOCYTES","resumen":"Sesquiterpene lactones (STLs) constitute agreat class of plant secondary metabolites generally found in Asteraceaefamily, with high diversity with respect to chemical structure as well asbiological activity. STLs have been classified into different groups such asguaianolides, germacranolides, melampolides, etc, according to their carboxylic skeleton.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Inamphibians, fully grown ovarian oocytes are arrested at the beginning ofmeiosis I, in the G2\/M of the cell cycle. Under stimulus of progesterone, thismeiotic arrest is released and meiosis progresses to metaphase II, a process knownas oocyte maturation. There are antecedents of the inhibitory effect on theprogression of meiosis of dehydroleucodine a lactone of guaianolide group.The purpose of this work was to determinewhether sesquiterpene lactones from the germacranolide and melampolide groupsmight act as G2\/M inhibitor agents on the meiosis of amphibian oocytes in vitro.Results indicated that the germacranolides: deoxyelephantopins caused highpercentages of inhibition, minimolide showed a moderate inhibitory effect and glaucolide A is inactive. In addition at the assayed dose (24 &#956;M) did no affect the viability ofthe oocytes, suggesting that these lactones are not toxic in our experimentalconditions. Results with melampolides(uvedalin, ehydrin,polymatin A, polymatin B) show inhibitory effects, however polymatin A andpolymatin B are toxic. In the case of enhydrin and uvedalin, the results showedinhibitory effect at the higher concentrations assayed (89% with 12µM and 98%with 24µM). However, in the reversibility assay, enhydrin showed low toxicitywith 7% of dead oocytes.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The results of this study suggest that the inhibitory activity on meiosis of Rhinella arenarum oocytes of sesquiterpene lactones tested, doesnot depend on which group they belong, ie the carboxylic skeleton, but probably to the arrangement and type of function groups present in the molecules.With respect to toxicity, all the lactones in thegermacranolide group assayed showed low toxicity. In contrast, in the lactonesof the melampolide group, important differences in toxicity were observed.While enhidryn and uvedalin showed low toxicity, polymatin A and B are highlytoxic.","palabras_clave":"OOCYTE MATURATION|SESQUITERPENE LACTONES|ANPHIBIAN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38515,"idioma_id":4,"titulo":"Taguchi's Methodology for Determining Optimum Operating Conditions in Hydrothermal Pretreatments Applied to Canola Seeds","resumen":"The aim of the present work was to determine the optimum operating conditions in hydrothermal pretreatments applied to canola seeds. The effect of these pretreatments on the canola oil extraction yield and quality was evaluated. Samples were characterized by proximate analysis. Acidity and peroxide value were studied as parameters for the determination of oil quality. Seeds were exposed to direct steam contact in an autoclave. Pretreatments were carried out using different temperatures (100, 120 and 130 8C), exposition times (5, 15 and 30 min) and seed granulometry (ground seeds, with a particle size in a range from 0.420 to 1.000mm; broken seeds, with a particle size ranging from 1.000 to 1.410mm, and entire seeds). After each hydrothermal pretreatment, oil extraction was carried out by the Soxhlet method (hexane). The Taguchi method was followed in order to explore the optimum operating conditions by using an L9 experimental design, and select the most favourable levels of each variable. Initial oil content was 44.2% dry basis (db). The selected optimum experiment, using a temperature of 120 8C, a time of 5 min and broken seeds, generated an oil yield increase of 20% compared with non?]hydrothermally treated seeds, whereas quality parameters remained within the accepted values for trade standards.","palabras_clave":"Taguchi's methodology| hydrothermal pretreatment|canola |oil yield and quality"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38516,"idioma_id":5,"titulo":"Sistematizando las prácticas: un hito en la construcción  de demandas en torno a la lucha por la vivienda en el barrio de La Boca.","resumen":"Se presenta una experiencia de trabajo desarrollada por el Grupo de Vivienda y Hábitat de la Boca, que tuvo por objetivo sistematizar colectivamente las prácticas que este grupo realizó en el devenir de la construcción de demanda social por las condiciones habitacionales de este barrio en contexto de pobreza en la Ciudad de Buenos Aires (Argentina). Esta intervención se realizó desde una perspectiva de animación sociocultural, educación y comunicación popular, enmarcadas en una concepción de educación permanente. El proceso de sistematización colectiva concretó una instancia de recuperación de la experiencia desde la reflexión crítica sobre la práctica y se conformó como un espacio de producción de conocimiento enmacipador y de fortalecimiento de la organización grupal y participación comunitaria. Se hizo hincapié en instancias que permitieran dar la voz a los sujetos participantes, logrando su empoderamiento, aumento de su autonomía y del acceso a la ciudadanía. ","palabras_clave":"Educación Popular|Demandas sociales|Derechos|Vivienda"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38517,"idioma_id":4,"titulo":"Detection and characterization of Shiga toxin producing Escherichia coli, Salmonella spp and Yersinia strains from human, animal and food samples in San Luis, Argentina.","resumen":"Shiga toxin producing Escherichia coli (STEC), Salmonella spp., and Yersinia species was investigated in humans, animals, and foods in San Luis, Argentina. A total of 453 samples were analyzed by culture and PCR. The antimicrobial susceptibility of all the strains was studied, the genomic relationships among isolates of the same species were determined by PFGE, and the potential virulence of Y. enterocolitica strains was analyzed. Yersinia species showed higher prevalence (9\/453, 2.0%, 95% CI, 0.7?3.3%) than STEC (4\/453, 0.9%, 95% CI, 0?1.8%) and Salmonella spp. (3\/453, 0.7%, 95% CI, 0?1.5%). Y. enterocolitica and Y. intermedia were isolated from chicken carcasses (6\/80, 7.5%, 95% CI, 1.5?13.5%) and porcine skin and bones (3\/10, 30%, 95% CI, 0?65%). One STEC strain was recovered from human feces (1\/70, 1.4%, 95% CI, 0?4.2%) and STEC stx1\/stx2 genes were detected in bovine stools (3\/129, 2.3%, 95% CI, 0?5.0%). S. Typhimurium was isolated from human feces (1\/70, 1.4%, 95% CI, 0?4.2%) while one S. Newport and two S. Gaminara strains were recovered from one wild boar (1\/3, 33%, 95% CI, 0?99%).The knowledge of prevalence and characteristics of these enteropathogens in our region would allow public health services to take adequate preventive measures.","palabras_clave":"DETECTION |CHARACTERIZATION|STEC|SALMONELLA|YERSINIA|FOOD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38518,"idioma_id":4,"titulo":"Synergy between Graphene and Au Nanoparticles (Heterojunction) towards Quenching, Improving Raman Signal, and UV Light Sensing","resumen":"Here, we developed a simple method for obtaining a   heterojunction composed of graphene (G) and surfactant-coated Au   nanoparticles (NPs) to measure the film conductivity and surface   enhanced Raman scattering (SERS). Monolayer G is obtained by chemical   vapor deposition (CVD) and transferred via poly(methyl methacrylate)   (PMMA) to microfabricated Au electrodes, glass, and silicon.   Post-synthesis treatments of G with PMMA and ozone (O3) showed 1 and 6   orders of magnitude decrease in the conductivity, respectively. The   heterojunction formation with Au NPs had no major effect on G   conductivity. In this work is demonstrated that G quenches more than 90%   of the combined photoluminescence and fluorescence of Au NPs and Rhodamine B (RhB), respectively. Signal quenching permitted quantitative analysis of SERS of RhB on various substrates including as-transferred graphene, oxidized graphene (OG), and the heterojunction. While G is mainly responsible for quenching photoluminescence and fluorescence, around 3 orders of magnitude increase SERS activity for RhB was accomplished by the heterojunction. Finally, we wanted to correlate changes in the current during UV light sensing experiments. We found striking differences in the sensing pro!les at different UV energies. KEYWORDS: graphene, nanoparticles, heterojunction, surface enhanced-Raman scattering, quenching, photoluminescence, and fluorescence.","palabras_clave":"Graphene|Nanoparticles|heterojunction|SERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38519,"idioma_id":4,"titulo":"Risk genes in head and  neck cancer: a systematic review and meta-analysis of last 5 years.","resumen":"The aim of this work was to identify risk genes related to the development and progression of squamouscell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates. Eligible gene\/polymorphismstudies were identified by electronic searches. Individual participant data of 8540 patientswith HNC and 9844 controls from 19 genetic studies were analyzed, yielding adjusted (tobacco, gender,age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls. Ameta-analysis was done on the studies that applied fixed and random models. People have an increaseof polymorphism expression related to inflammation (NFKB1-294-ATTG, TNFa308-A2A2\/A2A1, andTNFb252- B2B2\/B2B1) or carcinogenic metabolism (GSTM1 null, and CYP1A1 m1\/m1), representativeof malignancy development. Furthermore, the increased expression of genes associated with the stabilizationand repair of the cellular (OGG1-Asp267Asn, Ser279Gly Ile253Phe, 1578A > T, 1582C > T Ala399-Glu (1542C > A) 1582insG 1543_1544delCT), and genes associated with the regulation of proliferation,apoptosis or tumor survival (miRNA499-CT\/CC, CRYABC802G-CG\/GG) are considered as risk factors. Inthis scheme, only the polymorphisms of ADH7A92G-GG and DEC1606-T\/C genes are protective againstmalignancy transformation. The TP53, GSTM1 and CYPA1genes have been evaluated in more than onestudy and analyzed for homogeneity in each genotype. The meta-analysis showed no significant associationbetween different allelic variants of Arg72Pro rs1042522 and SCCHN risk.In a model of tumorigenesis, an increased risk of SCCHN is associated with DNA repair and DNA stabilizationgenes. In addition, the polymorphisms involved in inflammation and carcinogenic metabolismprocesses represent an increased risk of SCCHN.","palabras_clave":"Head|Neck|Cancer|Meta-analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38520,"idioma_id":4,"titulo":"Synergy between glyphosate- and cypermethrin-based pesticides during acute exposures in tadpoles of the common South American Toad Rhinella arenarum","resumen":"The herbicide glyphosate and the insecticide cypermethrin are key pesticides of modern management in  soy and corn cultures. Although these pesticides are likely to co-occur in ephemeral ponds or aquatic  systems supporting amphibian wildlife, the toxicological interactions prevailing in mixtures of these  two pesticides have been little studied. The current study evaluated the toxicity of equitoxic and nonequitoxic  binary mixtures of glyphosate- and cypermethrin-based pesticides to tadpoles of the common  South American toad, Rhinella arenarum. Two different combinations of commercial products were  tested: glyphosate Glifosato Atanor + cypermethrin Xiper and glyphosate Glifoglex + cypermethrin  Glextrin. When tested individually, the formulations presented the following 96 h-LC50s: Glifosato  Atanor 19.4 mg ae L1 and Glifoglex 72.8 mg ae L1, Xiper 6.8 mg L1 and Glextrin 30.2 mg L1.  Equitoxic and non-equitoxic mixtures were significantly synergic in both combinations of commercial  products tested. The magnitude of the synergy (factor by which toxicity differed from concentration  addition) was constant at around twofold for all tested proportions of the glyphosate Glifoglex +  cypermethrin Glextrin mixture; whereas the magnitude of the synergy varied between 4 and 9 times  in the glyphosate Glifosato Atanor + cypermethrin Xiper mixture. These results call for more research  to be promptly undertaken in order to understand the mechanisms behind the synergy observed and to  identify and quantify the extent of its environmental impacts.","palabras_clave":"PESTICIDES|AMPHIBIANS|MIXTURES|CYPERMETHRIN|GLYPHOSATE|AGRICULTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38521,"idioma_id":4,"titulo":"Minimizing the total cost of multi effect evaporation systems for seawater desalination","resumen":"A mathematical model developed recently by the authors is extended into a non linear mathematical programmingproblemto determine the nominal optimal sizing of equipment (heat transfer area) and optimal operationconditions that satisfy a fixed nominal production of freshwater at minimumtotal annual cost. Relativemarginalvalues computed fromthe optimized results and a global sensitivity analysis are then used to rank the process parametersaccording to their influences on the total cost. Once the nominal design and operating conditions are determined,a new optimization problem is stated: Is it possible to increase (using the nominal optimal design) thewater production over the nominal capacity of production? Thus, the new optimization problem consists of themaximization of the distillate production. Optimization results for both design problems are presented anddiscussed in detail. One of the obtained results reveals that the increase of the distillate production in 20% overthe nominal capacity (200 kg\/s), leads to increases in the total operating cost from 10.8 to 11.4 million US$\/yrwhile the seawater flow rate and the steam temperature increase about 23 and 5%, respectively.","palabras_clave":"DESALINATION OPTIMIZATION|WATER PRODUCTION|OPTIMAL COSt"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38522,"idioma_id":4,"titulo":"Cerulenin inhibits unsaturated fatty acids synthesis in Bacillus subtilis by modifying the input signal of DesK thermosensor","resumen":"Bacillus subtilis responds to a sudden decrease in temperature by transiently inducing the expression of the des gene encoding for a lipid desaturase, delta 5-Des, which introduces a double bond into the acyl chain of preexisting membrane phospholipids. This delta 5-Des-mediated membrane remodeling is controlled by the cold-sensor DesK. After cooling, DesK activates the response regulator DesR, which induces transcription of des. We show that inhibition of fatty acid synthesis by the addition of cerulenin, a potent and specific inhibitor of the type II fatty acid synthase, results in increased levels of short-chain fatty acids (FA) in membrane phospholipids that lead to inhibition of the transmembrane-input thermal control of DesK. Furthermore, reduction of phospholipid synthesis by conditional inactivation of the PlsC acyltransferase causes significantly elevated incorporation of long-chain FA and constitutive upregulation of the des gene. Thus, we provide in vivo evidence that the thickness of the hydrophobic core of the lipid bilayer serves as one of the stimulus sensed by the membrane spanning region of DesK","palabras_clave":"MEMBRANE THICKNESS|TWO-COMPONENT SYSTEM|BACILLUS|SIGNAL TRANSDUCTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38523,"idioma_id":4,"titulo":"Using a Microbial Physiologic and Genetic Approach to Investigate How Bacteria Sense Physical Stimuli.","resumen":"A laboratory exercise was designed to illustrate how physical stimuli such as temperature and light are sensed and processed by bacteria to elaborate adaptive responses. In particular, we use the well-characterized Des pathway ofBacillus subtilis to show that temperature modulates gene expression, resulting ultimately in modification of the levels of unsaturated fatty acids required to maintain proper membrane fluidity at different temperatures. In addition,we adapt recent findings concerning the modulation by light of traits related to virulence such as motility and biofilm formation in the chemotropic bacterium Acinetobacter baumannii. Beyond the theoretical background that this activity provides regarding sensing of environmental stimuli,the experimental setup includes approaches derived from classic genetics, microbiology, andbiochemistry. The incorporation of these kind of teaching and training activitiesin middle-advanced Microbiology or Bacterial Genetics courses promotes acquisition of general and specific techniques and improves student?s comprehension of scientificliterature and research. VC 2014 by The International Unionof Biochemistry and Molecular Biology, 42(4):305?322,2014","palabras_clave":"Microbial |Genetic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38524,"idioma_id":4,"titulo":"Synthesis, Spectroscopic characterization and Theoretical calculations of ClF2CC(O)N=PCl3 ([chloro(difluor)acetyl]phosphorimidic trichloride)","resumen":"      &nbsp; Thesynthesis of [chloro(difluor)acetyl]phosphorimidic trichloride&nbsp; (ClF2CC(O)N=PCl3),together with a tentative assignment of the vibrational, NMR and mass spectra, arereported. Quantum chemical calculations (MP2 and B3LYP methods with 6-311+G(d)and 6&#8209;311+G(2df,p) basis sets) predict three stable conformers in the gas phase(syn, gauche and anti, definedaccording to the rotation around both the Cl&#8209;C&#8209;C&#8209;N and the C&#8209;C&#8209;N&#8209;P dihedralangles). However, only a single C1symmetry conformer is observed in the liquid phase, possessing the C=O doublebond in synperiplanar orientation with respect to the P=N double bond,and the Cl-C bond distorted from the plane defined by the CC(O)NP entity. ANatural bond orbital (NBO) analysis was carried out for the title compound andrelated molecules in order to provide an explanation about the electronic properties","palabras_clave":"Análisis Vibracional"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38525,"idioma_id":4,"titulo":"From new simple aliphatic to aromatic heterocycles built from 2- chloroethylisocyanate","resumen":"New routes for gas phase thermal reactions of 2-chloroethylisocyanate are presented. They can be tuned by simply changing the material of the reactor and the temperature. Many interesting products are formed, including pyrazines and novel imidazolidine-2-ones. A comprehensive analysis that included high level ab-initio calculations have been carried out. Beyond the general agreement found with experimental results, the most relevant information is that, irrespective of the material of the reactor, all the products can be explained through a common unique key intermediate.","palabras_clave":"heterocycles"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38526,"idioma_id":4,"titulo":"Deleterious effects of wastewater on the health status of fish: A field caging study","resumen":"We carried out a caging field experiment to assess the potential effects of an untreated sewage effluent          on the health status of Prochilodus lineatus. We analyzed multiple biomarker responses, which included          morphological indices, biochemical and hematological parameters as well as oxidative stress markers.          In addition, we investigated the energetic demand of that exposure. Our findings showed that fish          caged at the effluent showed a differential physiologic profile, suggesting a strong impact on fish health.          Particularly, mortality, monocytosis, transaminase increase, antioxidant enzyme activation, lipid oxidative          damage in several tissues and hepatic and muscle glycogen depletion were observed. According to          multivariate analysis, oxidative stress markers and metabolic parameters were key biomarkers to contribute          in separating fish caged at effluent site from those caged at upstream and downstream sites.          So, these biomarkers allied to a caging strategy are recommended for future environmental monitoring          assessments.    ","palabras_clave":"BIOMARKERS|BIOMONITORING|PROCHILODUS LINEATUS|SEWAGE EFFLUENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38527,"idioma_id":5,"titulo":"How Can Network-Pharmacology Contribute to Antiepileptic  Drug Development?","resumen":"Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are often involved in multiple diseases and frequently present co-expression patterns. Therefore, useful therapeutic information can be drawn from network representations of drug targets. Here, we discuss potential applications of drug-target networks in the field of antiepileptic drug development.","palabras_clave":"DRUG-PROTEIN NETWORKS|NETWORK ANALYSIS|EPILEPSY|DRUG REPOSITIONING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38528,"idioma_id":4,"titulo":"Heteromerization of PIP aquaporins affects their intrinsic permeability","resumen":"Abstract  The plant aquaporin plasma membrane intrinsic proteins (PIP) subfamily represents one of the main gateways for water exchange at the plasma membrane (PM). A fraction of this subfamily, known as PIP1, does not reach the PM unless they are coexpressed with a PIP2 aquaporin. Although ubiquitous and abundantly expressed, the role and properties of PIP1 aquaporins have therefore remained masked. Here, we unravel how FaPIP1;1, a fruit-specific PIP1 aquaporin from Fragaria x ananassa, contributes to the modulation of membrane water permeability (Pf) and pH aquaporin regulation. Our approach was to combine an experimental and mathematical model design to test its activity without affecting its trafficking dynamics. We demonstrate that FaPIP1;1 has a high water channel activity when coexpressed as well as how PIP1?PIP2 affects gating sensitivity in terms of cytosolic acidification. PIP1?PIP2 random heterotetramerization not only allows FaPIP1;1 to arrive at the PM but also produces an enhancement of FaPIP2;1 activity. In this context, we propose that FaPIP1;1 is a key participant in the regulation of water movement across the membranes of cells expressing both aquaporins.","palabras_clave":"Aquaporins|PIP1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38529,"idioma_id":5,"titulo":"Propuesta de evaluaciones parciales para el fortalecimiento de la construcción de conocimientos","resumen":"Eltrabajo aborda unaexperiencia innovadora en la evaluación de los conocimientos en unaasignatura de matemática aplicada y los resultados obtenidos en los variosciclos lectivos sucesivos. Su propósito es fortalecer la construcción deconocimientos de los estudiantes para resolver abstracciones de problemasutilizando la técnica de modelado y simulación. ","palabras_clave":"matemática aplicada,| construcción del conocimiento,| evaluaciones parciales. | integración curricular,"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38530,"idioma_id":5,"titulo":"?Mediaciones tecnológicas ¿Nuevas prácticas artísticas??","resumen":"En este trabajo analizamos algunas vinculaciones entre las producciones artísticas enmarcadas en las 'Nuevas tecnologías de la información y la comunicación' (TICs y las prácticas de producción y educación artística. Nos preguntamos por un lado, cómo impactan las nuevas tecnologías tanto en las producciones artísticas como en la educación artística.","palabras_clave":"TICs |Educación Artística|Cultura juvenil|herramientas culturales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38531,"idioma_id":5,"titulo":"Sistema de ayuda a la enseñanza de la Informática en Geografía basado en Moodle","resumen":"En la so cie dad al gu nos de los de sa fíos pre sen tes como la eco no mía mun dial ba sa da en conoci mien to, y la ar ti cu la ción en tre in no va ción, cien cia y tec no lo gía, de man dan a las Uni ver si dadesdar res pues ta de edu ca ción acor de a los tiem pos. El ar ti cu lo des cri be la im ple menta ción prelimi nar de un pro to ti po de sis te ma in for má ti co con tem plan do las ca rac te rís ti cas y fun cio nes delos En tor nos Vir tua les de En se ñan za Apren di za je, orien ta do a ges tio nar co no ci miento del ámbito de la Edu ca ción Su pe rior, es pe cí fi ca men te en la asig na tu ra In tro duc ción a la Com pu ta ción,de la Li cen cia tu ra en Geo gra fía. Se de sa rro lló bajo la pla ta for ma Mood le con el pro pó si to de utilizar lo como he rra mien ta com ple men ta ria en el pro ce so de en se ñan za- a pren di za je, mo de li zandola in te rac ción del es tu dian te, in gre san te a los es pa cios de Edu ca ción Su pe rior. El tra ba jo secom po ne de cua tro sec cio nes: la pri me ra re su me los fun da men tos abor da dos, en la se gun da sede ta lla la me to do lo gía uti li za da pro fun di zan do en la es pe ci fi ca ción de re que rimien tos fun cio nales,se adap tó la pla ta for ma Mood le en su ver sión 2.2 y se con tem pla ron los dis tin tos per fi les deusua rio. En la ter ce ra sec ción se des cri be el pro to ti po, se ca rac te ri za a los alum nos y sus co no cimientos pre vios. Los re sul ta dos pre li mi na res ob te ni dos, de mues tran que el uso de los re cur sosde en se ñan za me dia dos por Tec no lo gías de In for ma ción y la Co mu ni ca ción, la pro mo ción de actitu des de co o pe ra ción y co la bo ra ción y el for ta le ci mien to del vín cu lo do cen te-a lum no, ge ne rain for ma ción de re troa li men ta ción para avan zar en la im ple men ta ción de mo de los b- lear ning.Para fi na li zar, en la cuar ta sec ción, se pre sen tan al gu nas fu tu ras lí neas de tra ba jo","palabras_clave":"entorno virtual de aprendizaje|TIC|gestión del conocimiento|educación superior"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38532,"idioma_id":5,"titulo":"Algunas experiencias de generación de software de gestión","resumen":"Las innovaciones generadas por la implementación de sistemas de información son relevantes para la conformación de la sociedad del conocimiento. El trabajo consta de cuatro secciones. La primera contextualiza el ámbito en el cual se desarrollan los sistemas de información generados. En la segunda sección se sintetiza la metodología aplicada en el proceso de desarrollo de los mismos. La tercera describe algunas experiencias desarrolladas y orientadas a satisfacer requerimientos de empresas en el ámbito local. Finalmente se exponen las conclusiones y las futuras líneas de trabajo, con el propósito de aportar desde la Universidad a su contexto de influencia.","palabras_clave":"SOFTWARE|DESARROLLO WEB|TECNOLOGÍAS WEB|SOLUCIONES INFORMÁTICAS|EXPERIENCIAS EN EL MEDIO LOCAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38533,"idioma_id":4,"titulo":"Proline modulates the Trypanosoma cruzi resistance to reactive oxygen species and drugs through a novel D, L-proline transporter","resumen":"Trypanosoma cruzi, the etiological agent of Chagas´ disease, has a metabolism largely based on the consumption of glucose and proline. This amino acid is essential for host cells infection and intracellular differentiation. In this work we identified a proline transporter (TcAAAP069) by yeasts complementation assays and overexpression in Trypanosoma cruzi epimastigotes. TcAAAP069 is mono-specific for proline but presents an unusual feature; the lack of stereospecificity, because it is competitively inhibited by the D- enantiomer. Parasites overexpressing TcAAAP069 have an increased intracellular proline concentration, 2.6-fold higher than controls, as a consequence of a higher proline transport rate. Furthermore, augmented proline concentration correlates with an improved resistance to trypanocidal drugs and also to reactive oxygen species including hydrogen peroxide and nitric oxide, emulating natural physiological situations. The IC50s for nifurtimox, benznidazole, H2O2 and NO. were 125%, 68%, 44% and 112% higher than controls, respectively. Finally, proline metabolism generates a higher concentration (48%) of ATP in TcAAAP069 parasites. Since proline participates on essential energy pathways, stress and drug resistance responses, these results provide a novel target for the development of new drugs for the treatments for Chagas´ disease.","palabras_clave":"TRYPANOSOMA|PROLINE|RESISTANCE|STRESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38535,"idioma_id":4,"titulo":"Assessment of fine and sub-micrometer aerosols at an urban environment of Argentina","resumen":"Bulk aerosol samples collected during 2010 and 2011 at one receptor site in Córdoba City, Argentina, have been quantitatively analyzed to determine aerosol elemental composition by using SR-XRF. A receptor model analysis has been applied to ambient PM2.5 measurements. Four sources have been identified being their contributions: traffic: (13 ± 2) &#956;g m-3, SO4 2-\/combustion processes, including biomass burning: (15 ±1) &#956;g m-3, mineral dust: (7 ±2) &#956;g m-3 and industry: (8 ±1) &#956;g m-3. Source identification was carried out by inspection of key species in source profiles, seasonality of source contributions, comparison with literature data and the knowledge of the city; for the biomass burning contribution the MODIS burned area daily product was used to confirm wildfire events along the year. In addition, from May to August 2011, aerosols were collected in two additional size fractions (PM0.25-0.5, PM0.5-1) to investigate the toxic metal contributions to the finer fractions. An important result of this work is that toxic metals make an important contribution to the finest (PM0.25-0.5) size fraction. The results of the present analysis can help to demonstrate to local and national authorities the urgent need to carry out emission inventories, to implement air quality monitoring systems and to set regulations for PM2.5.","palabras_clave":"PM2.5, PM0.5-1 and PM0.25-0.5|Chemical Elements|PMF model|SR-XRF"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38536,"idioma_id":4,"titulo":"Robust Estimators for Generalized Linear Models","resumen":"In this paper we propose a family of robust estimators for generalized linear models. The  basic idea is to use an M-estimator after applying a variance stabilizing transformation to  the response. We show the consistency and asymptotic normality of these estimators. We  also obtain a lower bound for their breakdown point. A Monte Carlo study shows that the  proposed estimators compare favorably with respect to other robust estimators for  generalized linear models with Poisson response and log link.","palabras_clave":"M-estimators|Transformations|Breakdown point"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38537,"idioma_id":4,"titulo":"1-methyl-5-(trifluoromethyl)azafulvenium methide, an intermediate that leads the reactions through the 'unusual' cis-exo 1,3 and trans-exo 1,7 cycloadditions","resumen":"The generation and reactivity of a novel 1-methyl-5-trifluoromethyl-azafulvenium methide is described. Under microwave induced pyrolysis this intermediate could be trapped by dipolarophiles acting as a 4&#960; as well as 8&#960; dipole. Quantum chemical calculations carried out at the DFT level of theory allowed the rationalization of the results observed in the cycloaddition of 1-methyl-5-trifluoromethyl-azafulvenium methide with N-substituted maleimides. The study revealed that for 1,7-cycloadducts, the major products are obtained in trans- configuration from the unusual exo-cycloaddition mode, while for 1,3-cycloadducts, the cis-counterparts are obtained from this unexpected approach.  In addition, under flash vacuum pyrolysis or conventional thermolysis 1-methyl-5-trifluoromethyl-azafulvenium methide undergoes an allowed suprafacial sigmatropic [1,8]H shift leading to the formation of 2-methyl-3-trifluoromethyl-1vinyl-1H-pyrrole.","palabras_clave":"cycloadditions"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38539,"idioma_id":5,"titulo":"Entre cebiles, cuevas y pinturas. Una mirada a la estética antropomorfa del arte rupestre de La Tunita, Catamarca, Argentina","resumen":"En este trabajo realizamos una primera aproximación a la estética del arte rupestre prehispánico del sitio arqueológico La Tunita, en la Sierra de Ancasti (Provincia de Catamarca, Noroeste Argentino). Para ello se analizan las pinturas antropomorfas desde una perspectiva morfológica, material y contextual y se evalúan diferentes interpretaciones sobre el rol que estas figuras podrían haber desempeñado en la producción de determinadas experiencias sensoriales en el marco de posibles actividades rituales desarrolladas en estos espacios. Así, planteamos que el arte rupestre de La Tunita es el producto de un trabajo pautado y colectivo de preparación y confección de los motivos, atendiendo a todo lo que pueda interferir, aumentar o modificar el efecto estético. ","palabras_clave":"ARTE RUPESTRE|SIERRA DE ANCASTI|LA TUNITA|CATAMARCA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38540,"idioma_id":4,"titulo":"pH-responsive hydrogels to protect IgY from gastric conditions: in vitro evaluation","resumen":"AbstractOral administration of specific egg yolk immunoglobulin (IgY) is effective against a number of gastrointestinal  pathogens. However, the activity of orally administered IgY is  reduced rapidly, since IgY is sensitive to pepsin and low pH.  In this study, hydrogels containing acrylamide and acrylic  acid were synthesized and used to encapsulate IgY. The  capacity of these structures to load, protect and release IgY  and the interaction between IgY and hydrogels by FTIR  spectroscopy were studied. The particle size and swelling  percentage of hydrogels were highly dependent on the pH of  the buffer solution. As expected, pH-sensitive hydrogels had a  high IgY loading percentage (99.2±12.9 mg IgY\/mg hydrogel)  at pH 7.4. It means that each gel piece incorporated approximately 8.4±1.1 mg IgY. The results showed that the hydrogels  could efficiently incorporate IgY and retain it inside the polymer network at pH <2.2. However, IgY was slowly released at  basic pH and a high percentage remained inside. The IR  spectra show that IgY interacts with the hydrogel in its network  with extended hydrogen bonds. The present study demonstrates that hydrogels particles can efficiently incorporate the  IgY but cannot show a controlled and sustained release of IgY  in simulated intestinal fluid probably due to hydrophobic  interactions with the polymer network. The stability of IgY in  simulated gastric fluid was greatly improved by encapsulation  in hydrogels. This approach provides information about a  novelty method for delivery of IgY for the prevention and  control of enteric diseases.","palabras_clave":"EGG YOLK IMMUNOGLOBULIN|pH-SENSITIVE HYDROGELS|DELIVERY|FT-IR SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38541,"idioma_id":4,"titulo":"The role of lactate on the immunomodulatory properties of the nonbacterial fraction of kefir","resumen":"The identification of components responsible for the bioactive properties of functional foods is of central interestin the food industry. In particular, fermented dairy products that are of a health benefit to the consumer mayexert those salutary effects through the constituent microorganisms per se and\/or through other bioactivecomponents. Kefir is a beverage obtained by the fermentation of milk with kefir grains containing differentlactic- and acetic-acid bacteria plus yeasts. We studied the immunomodulatory capacity of the nonbacterialfraction of kefir through approaches involving biochemistry and cell biology. Lactate, a major microbialmetabolicproduct, was identified as the component responsible for the modulation of certain innate immune epithelialresponse: At the concentrations found in kefir-fermented milk, lactate inhibits the activation of intestinalepithelial cells triggered by interleukin-1&#946;, tumor necrosis factor-&#945;, or flagellin. Lactate treatment furthermoreabrogates NF-&#954;B signaling in the cells, whose action could be responsible for the observed modulation of theinflammatory response. These findings provide a new perspective in the analysis of the biologic properties ofkefir-fermented-milk products.","palabras_clave":"Kefir|Lactate|Immunomodulation|Intestinal epithelium|Innate response"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38542,"idioma_id":4,"titulo":"Fear-potentiated behaviour is modulated by central amygdala angiotensin II AT1 receptors stimulation","resumen":"Central nucleus of the amygdala (CeA) is one of the most important regulatory centres for the emotional processes. Among the different neurotransmitter systems present in this nucleus, AT1 receptors have been also found, but their role in the generation and modulation of emotions is not fully understood. The present work evaluated the effect of intra-amygdalar injection of losartan (AT1 receptor antagonist) and angiotensin II (Ang II) in the anxiety state induced by fear-potentiated plus maze in male Wistar rats. Fear in the elevated plus maze can be potentiated by prior inescapable footshock stress. The decrease in the time spent in the open arms induced by the inescapable footshock was totally prevented by losartan (4 pmol) administration in CeA. It was also found that Ang II (48 fmol) administration decreased the time spent in the open arms in animals with or without previous footshock exposure. The locomotor activity and grooming behaviour were also evaluated. The results obtained from the different parameters analyzed allowed us to conclude that the Ang II AT1 receptors in CeA are involved in the anxiety state induced by stress in the fear-potentiated plus-maze behaviour.","palabras_clave":"Central |Nucleus |Amygdala |Anxiety |Angiotensin |Losartan |AT1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38543,"idioma_id":4,"titulo":"DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations","resumen":"              Background:  The brain is a common target of metastases for melanoma patients. Little is known  about the genetic and epigenetic alterations in melanoma brain metastases (MBMs).  Unraveling these molecular alterations is a key step in understanding their  aggressive nature and identifying novel therapeutic targets.               Methods:  Genome-wide DNA methylation analyses of MBMs (n=15) and normal brain tissues(n=91)  and simultaneous multigene DNA methylation and gene deletion analyses of  metastatic melanoma tissues(99 MBM and 43 extra-cranial metastases) were  performed. BRAF and NRAS mutations were evaluated in MBMs by targeted sequencing.              Results:  MBMs showed significant epigenetic heterogeneity. RARB, RASSF1, ESR1, APC, PTEN and CDH13 genes were frequently  hypermethylated. Deletions were frequently detected in the CDKN2A\/B locus. 46.1% and 28.8% of MBMs had BRAF and NRAS missense  mutations, respectively. Compared to lung and liver metastases, MBMs exhibited  higher frequency of CDH13  hypermethylation and CDKN2A\/B locus  deletion. Mutual exclusivity between hypermethylated genes and CDKN2A\/B locus deletion identified two  clinically-relevant molecular subtypes of MBMs. CDKN2A\/B deletions were associated with multiple MBMs and frequently  hypermethylated genes with shorter time to brain metastasis.               Conclusions:  Melanoma cells that colonize the brain harbor numerous genetically and  epigenetically altered genes. This study presents an integrated genomic and  epigenomic analysis that reveals MBM-specific molecular alterations and  mutually exclusive molecular subtypes.   ","palabras_clave":"CANCER PROGRESSION|GENE DELETION|GENOME-WIDE DNA METHYLATION|MELANOMA BRAIN METASTASIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38544,"idioma_id":4,"titulo":"Fossil localities of the Santa Cruz Formation (Early Miocene, Patagonia, Argentina) prospected by Carlos Ameghino in 1887 revisited and the location of the Notohippidian","resumen":"Between January and September of 1887 Carlos Ameghino carried out his first geologic and paleontological expedition to the Río Santa Cruz, Patagonia. Based on the fossils and geologic information compiled, in 1887 and 1889, Florentino Ameghino named more than 120 new species of extinct mammals and his Formación Santacruceña and Piso Santacruceño (Santacrucian stage). Data published by both brothers state that the specimens were collected in outcrops by the Río Santa Cruz, between 90 and 200 km west of its mouth. However, information in the posthumously published letters and Travel Diary of C. Ameghino allows us to recognize a fourth locality, Río Bote, at about 50 km further southwest. In 1900, 1902, F. Ameghino divided the Piso Santacruceño in a younger étage Santacruzienne and older étage Notohippidéen, restricting the geographical distribution of the latter to Kar Aiken locality, northeast of Lago Argentino. However, 15 of the 54 species that F. Ameghino listed as exclusively Notohippidian stage already had been named on specimens collected South to the Río Santa Cruz in 1887, two year prior to C.Ameghino?s first visit to Kar Aiken. Based on historical information and several expeditions to the Río Santa Cruz and its environs, in this contribution we establish the geographical locations of the 1887 localities, formalize their names, evaluate the stratigraphic position of the fossil-bearing levels, and analyze the geographic extension of the Notohippidian, inferring that Río Bote is where C. Ameghino first collected species that came to define the Notohippidian.","palabras_clave":"Carlos Ameghino|Río Santa Cruz|Fossil Mammals|Sntacrucian|Nothoippidian"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38545,"idioma_id":4,"titulo":"'Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice'","resumen":"Purpose: Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality. C-terminal-binding protein 1 (CtBP1) is a transcription repressor of tumor suppressor genes and is activated by NADH binding. High calorie intake decreases intracellular NAD+\/NADH ratio. The aim of this work was to assess the effect of high-fat diet (HFD) and CtBP1 expression modulation over prostate xenograft growth. Experimental Design: We developed a metabolic syndrome-like disease in vivo model by feeding male nude mice with HFD during 16 weeks. Control diet (CD)-fed animals were maintained at the same conditions. Mice were inoculated with PC3 cells stable transfected with shCtBP1 or control plasmids. Genome-wide expression profiles and Gene Set Enrichment Analysis (GSEA) were performed from PC3. shCtBP1 versus PC3.pGIPZ HFD-fed mice tumors. Results: No significant differences were observed in tumor growth on CD-fed mice; however, we found that only 60% of HFD-fed mice inoculated with CtBP1-depleted cells developed a tumor. Moreover these tumors were significantly smaller than those generated by PC3.pGIPZ control xenografts. We found 823 genes differentially expressed in shCtBP1 tumors from HFD-fed mice. GSEA from expression dataset showed that most of these genes correspond to cell adhesion, metabolic process, and cell cycle. Conclusions: Metabolic syndrome-like diseases and CtBP1 expression cooperate to induce prostate tumor growth. Hence, targeting of CtBP1 expression might be considered for prostate cancer management and therapy in the subset of patients with metabolic syndromes. © 2014 American Association for Cancer Research.","palabras_clave":"cáncer de próstata|CtBP1|síndrome metabólico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38546,"idioma_id":4,"titulo":"Seasonal Changes in Plasma Levels of Sex Hormones in the Greater Rhea (Rhea americana), a South American Ratite with a Complex Mating System","resumen":"Seasonal rhythm in sex hormones has been extensively studied in birds, as well as its relationship with the type of mating system. The Greater Rhea (Rhea americana), a South American ratite species, reproduces seasonally and has a complex mating system: female-defense polygyny and sequential polyandry. The present study aimed at analyzing the endocrine basis of reproduction in this species and its relationship with its mating system. We used HPLC and electrochemiluminescence techniques to identify and measure plasma testosterone and estradiol levels. Annual oscillations in sex hormones, testosterone and estradiol, in adult males and females were observed. Lower levels of these hormones were exhibited during the non reproductive season (February to July), whereas their maximum values were reached in September for males and November-December for females. These fluctuations reflect the seasonal changes in gonadal function. By contrast, no significant sex hormones oscillations were observed in juvenile males and females (negative control of seasonal changes).  Greater rheas maintain high testosterone and estradiol levels throughout the reproductive period. The high testosterone levels during incubation and chick rearing did not inhibit parental behavior in males, which appears not to conform to the ??Challenge Hypothesis??. In females, the high estradiol levels throughout the reproductive season would be needed to sustain their long egg-laying period.","palabras_clave":"RHEA AMERICANA|SEX HORMONES|MATING SYSTEM|CHALLENGE HYPOTHESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38547,"idioma_id":4,"titulo":"Volatile Profile Characterization of Extra Virgin Olive Oils from Argentina by HS-SPME\/GC-MS and Multivariate Pattern Recognition Tools","resumen":"The distinctive aroma of virgin olive oil is attributed to a large number of chemical compounds of different classes such as aldehydes, alcohols, esters, hydrocarbons, ketones, furans, and other volatile compounds that are not yet identified. The aim of the present study lies in the characterization of compound volatile profile of the most representative olive oil cultivars produced in Argentina. The methodology proposed was based on the development of headspace (HS)-SPME\/GC-MS with the subsequent analysis of the chemical fingerprints using a discriminant analysis method and a principal component analysis data compression strategy to distinguish olive oils from different varietal origins. Carboxen\/polydimethylsiloxane (75 &#956;m) fiber was the most efficient to trap volatile compounds. Optimization of the SPME conditions was also carried out using multivariate methods. To avoid the influence of factors other than the cultivar, olive trees were cultivated under the same agronomic and pedoclimatic conditions; olive fruits were picked at the same stage of ripeness, and their oils were extracted with the same processing system. Volatile fractions from oils of the analyzed cultivars consisted of a complex mixture of more than 40 compounds. Both quantitative and qualitative differences were found among cultivars. The analytical data association with multivariate analysis constitutes a reliable analytical tool with potential ability to discriminate monovarietal extra virgin olive oil from Argentina.","palabras_clave":"GC-MS|SPME|OLIVE OIL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38548,"idioma_id":4,"titulo":"Non-linear aeroelasticity: an approach to compute the response of three-blade large-scale horizontal-axis wind turbines","resumen":"In this work, we present an aeroelastic model intended for three-blade large-scale horizontalaxis wind turbines. This model results from the coupling of an existing aerodynamic model and a structural model based on a segregated formulation derived in an index-based notation that enables combining very dierent descriptions such as rigid-body dynamics, assumed-modes techniques and nite element methods. The developed structural model comprises a supporting tower, a nacelle, which contains the electrical generator, power electronics and control systems, a hub in which the blades are connected to a rotating shaft, and three blades which extract  energy from the wind. Flexible blades are discretized into beam finite  elements and the exible tower is discretized into assumed modes. The nacelle and hub are considered rigid. To illustrate the exibility of the structural modeling, the tower, nacelle and hub are modeled as a single  kinematic chain and each blade is modeled separately. To establish the blade-hub attachments, we use constraint equations. Thus, the resulting equations are dierential algebraic. We also expose a general procedure for connecting the non-matching structural and aerodynamic meshes.  Finally, we present results, some of them are validations, which prove that our new approach is reliable and does have capability to capture non-linear phenomena such as centrifugal stiening, flutter and large yaw errors, and the remaining correspond to the aeroelastic response of a wind turbine during a start-up maneuvering.","palabras_clave":"Three-blade large-scale horizontal-axis wind turbines|segregated structural formulation|non-linear-unsteady vortex-lattice method|inter-model combination|non-linear aeroelasticity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38549,"idioma_id":4,"titulo":"SANDWICH-CULTURED RAT HEPATOCYTES AS AN IN VITRO MODEL TO STUDY CANALICULAR TRANSPORT ALTERATIONS IN CHOLESTASIS","resumen":"At present, it has not been systematically evaluated whether the functional alterations induced by cholestatic  compounds in canalicular transporters involved in bile formation can be reproduced in sandwich cultured rat  hepatocytes (SCRHs). Here, we focused on two clinically relevant cholestatic agents, such as estradiol 17&#946;-Dglucuronide  (E17G) and taurolithocholate (TLC), also testing the ability of dibutyryl cyclic AMP (DBcAMP) to  prevent these cholestatic effects. SCRHs were incubated with E17G (200 &#956;M) or TLC (2.5 &#956;M) for 30 min, with  or without pre-incubation with DBcAMP (10 &#956;M) for 15 min. Then, the increase in glutathione methyl fluorescein  (GS-MF)-associated fluorescence inside the canaliculi was monitored by quantitative time-lapse imaging and  Mrp2 transport activity was calculated by measuring the slope of the time-course fluorescence curves during the  initial linear phase, which was considered to be the Mrp2-mediated initial transport rate (ITR). E17G and TLC  impaired canalicular bile formation, as evidenced by a decrease in both the bile canaliculus volume and the bile  canaliculus width, estimated from 3D and 2D confocal images, respectively. These compounds also decreased ITR  and induced retrieval of Mrp2, a main pathomechanism involved in their cholestatic effects. Finally, DBcAMP  prevented these cholestatic manifestations, and its well-known choleretic effect was evident from the increase in  the canalicular volume\/width values; this choleretic effect is associated in part with its capability to increase Mrp2  activity, evidenced here by the increase in ITR of GS-MF. Our results support the use of SCRHs as an in vitro  model for studies on the mechanisms of cholestasis and choleresis.","palabras_clave":"SANDWICH-CULTURED RAT HEPATOCYTES|CHOLESTASIS|MRP2|E17G"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38550,"idioma_id":4,"titulo":"Detecting Broken Rotor Bars With Zero-Settings Protection","resumen":"Broken rotor bars in induction motors can be dependably detected by analyzing the current signatures under sufficient motor load conditions. Detection becomes less dependable under light motor load conditions. There are also cases in which tolerable motor operating conditions generate current signatures similar to those of motors with broken rotor bars. These cases may present security concerns when the detection element is set to trip the motor and to send alarms.  In this paper, we:  Show how broken rotor bars cause characteristic current signatures.  Show how to detect broken rotor bars with a zero-setting protection element, which uses the current signature method.  Use cases with different motor operating and fault conditions to analyze the performance of the zero-setting broken bar protection element.  Identify cases when the current signature method is dependable and cases when security is a concern.  Present solutions to address security concerns.","palabras_clave":"Induction motor protection|broken rotor bars|squirrel cage rotor|induction motor relaying"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38551,"idioma_id":4,"titulo":"Brokers Beyond Clientelism: A New Perspective Through the Argentine Case","resumen":"Party machines and brokers have been widely researched in political science since 1950, yet a full description of brokers roles is still missing. This article contributes by describing in detail the many roles brokers perform for their parties and explaining why each broker performs all these roles. In particular, it shows that besides fulfilling clientelistic strategies, brokers perform important executive governability functions once their party is in power. Brokers multitask because they have the neighborhood knowledge required to successfully perform political activities at the local level. Moreover, performing nonclientelistic roles prepares brokers to perform clientelistic strategies. The article also presents a novel theoretical account for why voters abide by the clientelistic deal. Based on interviews with 120 brokers, it analyzes the complete set of brokers strategies, and detailed narrative accounts show the clientelistic machine at work.","palabras_clave":"brokers|clientelism|subnational politics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38552,"idioma_id":4,"titulo":"IDO is highly expressed in breast cancer and breast cancer-derived circulating microvesicles and associated to aggressive types of tumors by in silico analysis","resumen":"Indoleamine-2,3-dioxygenase (IDO) has been established as a normal   mechanism of peripheral tolerance and immunosuppression. Besides,   malignant tumors release microvesicles (MV) related with tumor   dissemination. The aims of this study were to determine the expression   of IDO in breast cancer and circulating microvesicles from breast cancer   patients and to perform an in silico analysis to find genes   co-expressed to IDO. One hundred and twenty-two tissue and serum breast   samples (91 malignant, 21 benign, and 10 normal), and MCF7, MDA-MB-231,   and T47D breast cancer cell lines were included. Standard   immunohistochemistry (IHC), immunocytochemistry (ICC), Western blot   (WB), and RT-PCR were employed. Microvesicle isolation from plasma   samples was obtained by serial centrifugation and ultracentrifugation.   By IHC, 60 % breast cancer, 43 % benign, and 20 % normal samples were   positive. Significant differences were found among normal, benign, and   malignant samples. Breast cancer stages I, II, and III expressed IDO in   42, 66, and 71 % of samples, respectively, while breast cancer cell   lines also reacted; by WB, 9\/25 microvesicles fractions showed bands at   42 kD. In silico analysis of IDO 1 gene expression in breast cancer   showed its association with several genes related to immune response and   apoptosis. Moreover, IDO and co-expressed genes were found   predominately in basal and erbB2 subtypes. The cumulative data indicate a   high expression of IDO in breast cancer which increased with higher   stages. Furthermore, IDO was found in association with circulating   breast cancer MV, while experimental and in silico gene expression   revealed that IDO was mainly expressed in a triple-negative subgroup.","palabras_clave":"Breast|Cancer|IDO|Exosomes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38553,"idioma_id":4,"titulo":"A theory of 2-pro-objects","resumen":"In [1], Grothendieck develops the theory of pro-objects  over a category C . The fundamental property of the category  Pro(C) is that there is an embedding c: C -->Pro(C) , the category  Pro(C) is closed under small cofiltered limits, and these limits are  free in the sense that for any category E closed under small cofiltered  limits, pre-composition with c determines an equivalence of  categories Cat(Pro(C); E)_+ ~= Cat(C; E) , (where the '+' indicates  the full subcategory of the functors preserving cofiltered limits).  In this paper we develop a 2-dimensional theory of pro-objects.  Given a 2-category C , we define the 2-category 2-Pro(C) whose  objects we call 2-pro-objects. We prove that 2-Pro(C) has all the  expected basic properties adequately relativized to the 2-categorical  setting, including the universal property corresponding to the one  described above. We have at hand the results of Cat -enriched  category theory, but our theory goes beyond the Cat -enriched case  since we consider the non strict notion of pseudo-limit, which is  usually that of practical interest.","palabras_clave":"2-PRO-OBJECT|2-FILTERED|PSEUDO-LIMIT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38555,"idioma_id":4,"titulo":"CONTROL OF ANGIOGENESIS BY GALECTINS INVOLVES THE RELEASE OF PLATELET-DERIVED PRO-ANGIOGENIC FACTORS","resumen":"Platelets contribute to vessel formation through the release of   angiogenesis-modulating factors stored in their alpha-granules. Galectins, a   family of lectins that bind beta-galactoside residues, are up-regulated in   inflammatory and cancerous tissues, trigger platelet activation and   mediate vascularization processes. Here we aimed to elucidate whether   the release of platelet-derived proangiogenic molecules could represent   an alternative mechanism through which galectins promote   neovascularization. We show that different members of the galectin   family can selectively regulate the release of angiogenic molecules by   human platelets. Whereas Galectin (Gal)-1, -3, and -8 triggered vascular   endothelial growth factor (VEGF) release, only Gal-8 induced endostatin   secretion. Release of VEGF induced by Gal-8 was partially prevented by   COX-1, PKC, p38 and Src kinases inhibitors, whereas Gal-1-induced VEGF   secretion was inhibited by PKC and ERK blockade, and Gal-3 triggered   VEGF release selectively through a PKC-dependent pathway. Regarding   endostatin, Gal-8 failed to stimulate its release in the presence of   PKC, Src and ERK inhibitors, whereas aspirin or p38 inhibitor had no   effect on endostatin release. Despite VEGF or endostatin secretion,   platelet releasates generated by stimulation with each galectin   stimulated angiogenic responses in vitro including endothelial cell   proliferation and tubulogenesis. The platelet angiogenic activity was   independent of VEGF and was attributed to the concerted action of other   proangiogenic molecules distinctly released by each galectin. Thus,   secretion of platelet-derived angiogenic molecules may represent an   alternative mechanism by which galectins promote angiogenic responses   and its selective blockade may lead to the development of therapeutic   strategies for angiogenesis-related diseases.","palabras_clave":"PLATELETS|VEGF|ENDOTHELIUM|ANGIOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38556,"idioma_id":4,"titulo":"Outliers Detection in Audit Logs for Application Systems","resumen":"An outlier is defined as an observation that is significantly different from other data in its set. The auditor will employ many techniques, processes and tools to this end. Data mining is one of the media through which the auditor analyzes information. The enormous amount of information contained within transaction processing systems´ logs means auditors must employ automated systems for anomalous data detection. Several data mining algorithms were tested, especially those that deal specifically with classification and outlier detection. A group of these was selected to design and develop a process that makes utilization of them all in order to assist the auditor in anomalous data detection within audit logs. We have been successful in creating and ratifying an outlier detection process which works on alphanumeric fields in audit logs from an information system, thus making it a useful tool for system auditors performing data analysis tasks.","palabras_clave":"Outliers Detection|Audit Logs|Information Mining|Information Mining Process|Data Mining"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38557,"idioma_id":4,"titulo":"Monty Hall game: A host with limited budget","resumen":"In this paper we introduce a new version of the classical Monty Hall problem, where the host is trying to maximize the audience while restricted in its budget. This problem is related to the design of games with a predetermined outcome and decision-making process under uncertainty when the agent does not know if the received advice is favorable or not.","palabras_clave":"MONTY HALL|PROBABILITY|GAME THEORY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38558,"idioma_id":5,"titulo":"¿Cada voto cuenta igual? Una medición de irregularidades en los telegramas de la elección presidencial de 2011 en Argentina","resumen":"Este trabajo presenta los resultados que surgen al analizar una muestra aleatoria de más de seis mil telegramas de votación de mesas ubicadas en el conurbano bonaerense durante la elección presidencial de 2011. En más de un tercio de las mesas se observan irregularidades, que si bien no implican necesariamente la existencia de errores en el cómputo oficial de votos, son indicio indirecto del problema. Adicionalmente, se observa que las irregularidades son particularmente frecuentes en los municipios más pobres, lo cual sugiere que la voluntad política de un ciudadano de bajo ingreso es menos factible de ser respetada que la de un ciudadano rico.","palabras_clave":"elecciones|irregularidades|ciudadanía"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38559,"idioma_id":5,"titulo":"Organización y lucha obrera en la Argentina contemporánea:  La experiencia del Sindicato Marítimo de Pescadores (2000-2012)","resumen":"      En el presente artículo buceamos en las múltiples  experiencias de organización y lucha de los trabajadores del mar agrupados en  torno del Sindicato Marítimo de Pescadores (SIMAPE) entre 2000 y 2012. Para  llevar a cabo este sondeo nos hemos servido de diversas fuentes: entrevistas a  dirigentes sindicales, delegados y trabajadores, estatutos, convenios  colectivos, prensa escrita, expedientes ministeriales, observación de campo,  volantes y panfletos, listas de candidatos a elecciones, publicaciones de los  gremios, entre otras. El resultado de esta indagación está estructurada en una  introducción, tres apartados y una conclusión. En la introducción presentamos  los principales lineamientos interpretativos sobre la ?revitalización? sindical  y sus problemáticas asociadas. En el primer apartado realizamos una  contextualización histórica del proceso genético del SIMAPE. En el segundo apartado  nos ocupamos de presentar los rasgos principales de la estructura formal del  SIMAPE, así como de las prácticas organizativas concretas y cotidianas. En el  tercero y último apartado analizamos la participación de los trabajadores  marineros en la vida gremial, puntualizando en las elecciones, las protestas y  las negociaciones. Finalmente, presentamos las conclusiones de nuestra  investigación en forma de reflexiones y nuevas conjeturas que permiten revisar  nuestro acostumbrado y rutinizado abordaje de las experiencias sindicales.  ","palabras_clave":"SIMAPE|organización obrera,|reactivación sindical|marineros pescadores"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38561,"idioma_id":5,"titulo":"Supervivencia de VTEC O157 y no-O157 en agua de bebederos y materia fecal de bovinos","resumen":"Escherichia coli productor de verotoxina [verotoxin-producing E. coli (VTEC)] es el agente causal del síndrome urémico hemolítico (SUH), enfermedad que afecta principalmente a niños de edades comprendidas entre 6 meses y 5 años. La transmisión se produce por el consumo de alimentos contaminados, por el contacto directo con animales o con el medio ambiente y de persona a persona. En trabajos anteriores hemos determinado que el medio ambiente del tambo es un reservorio no animal de VTEC, por lo cual nos propusimos estudiar la supervivencia de 4 aislamientos VTEC (O20:H19; O91:H21; O157:H7 y O178:H19) en agua estéril de bebederos y en materia fecal de bovinos mediante el recuento de bacterias viables y la detección de genes de virulencia por PCR. Se demostró que la supervivencia de los distintos aislamientos VTEC (O157 y no-O157) varía en función de sus características intrínsecas y de las condiciones del medio ambiente en el que se encuentran. Las principales diferencias entre los aislamientos fueron el tiempo de supervivencia en los microcosmos y los recuentos máximos alcanzados. La capacidad para adaptarse y sobrevivir de estos microorganismos aumenta el riesgo de transmisióna las personas que trabajan en los establecimientos ganaderos o que se encuentran de visita en ellos, así como el riesgo de reinfección de los animales y de contaminación de los alimentos.","palabras_clave":"ESCHERICHIA COLI VEROTOXIGENICO|MEDIO AMBIENTE|TAMBO|AGUA|SUPERVIVENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38562,"idioma_id":4,"titulo":"Biological and probiotic characterization of  spontaneous phage-resistant mutants of Lactobacillus plantarum","resumen":"Four spontaneous phage-resistant mutants, previously isolated from Lactobacillus plantarum ATCC 8014 using a phage cocktail (ATCC 8014-B1 and ATCC 8014-B2), were characterized about their probiotic potential. Phage-resistant mutants exhibited, in general, the same properties as those found for Lb. plantarum ATCC 8014 strain. However, mutant M1 evidenced a remarkably high resistance to gastrointestinal passage. Low values of either &#946;-galactosidase activity or hydrophobicity were observed. Antimicrobial activity against Gram-negative and Gram-positive bacteria was evidenced and lactulose was the most fermented carbohydrate. Strains were sensitive to gentamicin, erythromycin, ampicillin and chloramphenicol, whereas production of biogenic amines was not observed. Finally, a selected phage-resistant mutant (M1) produced the same immunological response as the sensitive strain in mice fed for 10 consecutive days. These natural mutants, with similar or improved potentially probiotic characteristics regarding their sensitive strain, could be used during fermented food manufacture to minimize the phage attacks.","palabras_clave":"Lactobacillus plantarum|PHAGE COCKTAILS|PHAGE-RESISTANT MUTANTS|BIOLOGICAL RESISTANCE|PROBIOTIC POTENTIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38563,"idioma_id":4,"titulo":"Enhanced IRES activity by the 3' UTR element determines the virulence of FMDV isolates","resumen":"A reverse genetics approach was used to identify viral genetic determinants of the differential virulence displayed by two field foot-and-mouth disease virus (FMDV) strains (A\/Arg\/00 and A\/Arg\/01) isolated in Argentina during the 2000-2001 epidemics. A molecular clone of A\/Arg\/01 strain and viral chimeras containing the S-fragment or the internal ribosome entry site (IRES) of A\/Arg\/00 in the A\/Arg\/01 backbone were constructed and characterized. The IRES appeared as a determining factor of the lower level of A\/Arg\/00 replication in cell culture. High-throughput RNA probing revealed structural differences between both IRESs. Translation experiments using either synthetic viral RNAs (in vitro) or bicistronic plasmids (in vivo) showed that these IRESs´ activities differ when the viral 3´ untranslated region (UTR) is present, suggesting that their function is differentially modulated by this region. This work provides experimental evidence supporting the role of the IRES-3´UTR modulation in determining the level of FMDV replication in field strains.","palabras_clave":"FMDV,, , , , , | IRES|HSHAPE|RNA STRUCTURE|3?UTR|VIRULENCE|INFECTIOUS CDNA CLONE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38564,"idioma_id":4,"titulo":"Growth hormone administration patterns differently regulate epidermal growth factor signaling","resumen":"Current GH administration protocols imply frequent s.c. injections, resulting in suboptimalcompliance. Therefore, there is interest in developing delivery systems for sustained releaseof the hormone. However, GH has different actions depending on its continuous or pulsatileQ2 plasma concentration pattern. GH levels and circulating concentration patterns would beinvolved in the regulation of epidermal growth factor receptor (EGFR) expression in liver.Aberrant expression of this receptor and\/or its hyperactivation has been associated with thepathogenesis of different types of carcinoma. Considering that one of the adverse effectsassociated with GH overexpression and chronic use of GH is the increased incidence ofmalignancies, the aim of this study was to analyze the effects of GH plasma concentrationpatterns on EGFR expression and signaling in mice liver. For this purpose, GH was administered by s.c. daily injections to produce an intermittent plasma pattern or by osmoticpumps to provoke a continuous GH concentration. Results showed that intermittentinjections of GH induced an upregulation of liver EGFR content, augmented the response toEGF, and the induction of proteins involved in cell proliferation promotion in female mice.On the contrary, continuous GH delivery in male mice was associated with diminishedEGFR liver content and decreased EGF-induced signaling and expression of early genes.Results suggest that sustained delivery systems that allow continuous GH plasma patternswould be beneficial in terms of treatment safety referred to its actions on EGFR signaling and its promitogenic activity.","palabras_clave":"epidermal growth factor|growth hormone|administration patterns"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38565,"idioma_id":4,"titulo":"TMV-Cg Coat Protein stabilizes DELLA proteins","resumen":"    Background: Plant viral infections disturb defense regulatory networks during tissue invasion. Emerging evidence                demonstrates that a significant proportion of these alterations are mediated by hormone imbalances. Although the        DELLA proteins have been reported to be central players in hormone cross-talk, their role in the modulation of hormone        signaling during virus infections remains unknown.            Results: This work revealed that TMV-Cg coat protein (CgCP) suppresses the salicylic acid (SA) signaling pathway        without altering defense hormone SA or jasmonic acid (JA) levels in Arabidopsis thaliana. Furthermore, it was observed                that the expression of CgCP reduces plant growth and delays the timing of floral transition. Quantitative RT-qPCR        analysis of DELLA target genes showed that CgCP alters relative expression of several target genes, indicating that the        DELLA proteins mediate transcriptional changes produced by CgCP expression. Analyses by fluorescence confocal        microscopy showed that CgCP stabilizes DELLA proteins accumulation in the presence of gibberellic acid (GA) and that        the DELLA proteins are also stabilized during TMV-Cg virus infections. Moreover, DELLA proteins negatively modulated        defense transcript profiles during TMV-Cg infection. As a result, TMV-Cg accumulation was significantly reduced in the        quadruple-DELLA mutant Arabidopsis plants compared to wild type plants.            Conclusions: Taken together, these results demonstrate that CgCP negatively regulates the salicylic acid-mediated        defense pathway by stabilizing the DELLA proteins during Arabidopsis thaliana viral infection, suggesting that CgCP                alters the stability of DELLAs as a mechanism of negative modulation of antiviral defense responses.","palabras_clave":"Defense response|TMV-Cg, Coat protein|DELLA proteins|SA signaling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38566,"idioma_id":4,"titulo":"ISCHEMIC POSTCONDITIONING REDUCES INFARCT SIZE THROUGH THE &#945;-1 ADRENERGIC RECEPTOR PATHWAY","resumen":"          The &#945;1-adrenergic  receptors (&#945;1-ARs)  are involved in preconditioning. Given that certain intracellular pathways appear  to be shared by preconditioning and postconditioning, it is possible that  postconditioning could be also mediated by &#945;1-ARs. The objective was to evaluate, by analyzing  infarct size, if &#945;1-ARs  activation could trigger postconditioning; and also determine Akt and glycogen  synthase kinase-3&#946; (GSK-3&#946;)  phosphorylation. Langendorff-perfused rat hearts were subjected to 30 minutes  of ischemia and 120 minutes of reperfusion (I\/R; n=8). After 30 min of global  ischemia, we performed 6 cycles of reperfusion\/ischemia of 10 sec each,  followed by 120 min of reperfusion (postcon; n=9). In another postcon group, we  administered prazosin during postcon protocol (postcon + prazosin; n=7).  Finally, we repeated the I\/R group but prazosin (prazosin; n=7), phenylephrine  (PE; n=5) and clonidine (CL; n=6), were administered during the first 2 minutes  of reperfusion. Infarct size was measured using the triphenyltetrazolium  chloride technique. Total and phosphorylated Akt and mitochondrial GSK-3&#946; expression  were measured by Western blot. Infarct size was 58.1±5.1% in I\/R. Postcon and  PE reduced infarct size to 40.1±2.9% and 35.3±5.5% respectively (p&lt;0.05 vs.  I\/R). Postcon + prazosin administration abolished the beneficial effect on  infarct size (61.6±4.5%; p&lt;0.05 vs. postcon). Cytosolic Akt phosphorylation  and mitochondrial GSK-3&#946;  phosphorylation were higher in the postcon and PE groups compared with the I\/R  and postcon + prazosin groups. Prazosin or clonidine administration did not modify  neither protein expression nor infarct size. Our data demonstrate that  postconditioning decrease infarct size by activation of the &#945;1-AR pathway  through Akt and GSK-3&#946;  phosphorylation.  ","palabras_clave":"ISCHEMIC POSTCONDITIONING|ALPHA-1 ADRENERGIC RECEPTOR|INFARCT SIZE|GLYCOGEN SYNTHASA KINASE 3-&#946;"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38567,"idioma_id":5,"titulo":"REVISIÓN SISTEMÁTICA Y TAXONÓMICA DEL GÉNERO SCELIDOTHERIUM OWEN, 1839 (XENARTHRA, PHYLLOPHAGA, MYLODONTIDAE)","resumen":"The subfamily Scelidotheriinae (Xenarthra, Phyllophaga,Mylodontidae) has been recorded since the ?Friasian? sensu lato (middle Miocene) to Lujanian (late Pleistocene-early Holocene).For the Quaternary four genera: Scelidotherium, Valgipes, Scelidodon and Catonyx are recognized and recorded in Argentina,Bolivia, Chile, Ecuador, Peru and Uruguay. The authors performed a systematic and taxonomic study of the genus Scelidotheriumsensu lato (middle Miocene) to Lujanian (late Pleistocene-early Holocene).For the Quaternary four genera: Scelidotherium, Valgipes, Scelidodon and Catonyx are recognized and recorded in Argentina,Bolivia, Chile, Ecuador, Peru and Uruguay. The authors performed a systematic and taxonomic study of the genus ScelidotheriumScelidotherium, Valgipes, Scelidodon and Catonyx are recognized and recorded in Argentina,Bolivia, Chile, Ecuador, Peru and Uruguay. The authors performed a systematic and taxonomic study of the genus ScelidotheriumScelidotheriumOwen of Argentina. Two valid species are recognized: (i) S. bravardi Lydekker presents records in the provinces of BuenosAires during the Ensenadan (ca. 1 My - 0.4 My BP; early Pleistocene-middle Pleistocene) and in the Pleistocene of the provinceof San Luis, and (ii) S. leptocephalum Owen presents records during Bonaerian and Lujanian (ca. 0.4 My - 8.5 ky BP; middlePleistocene-early Holocene) in the Province of Buenos Aires, in the Lujanian of the provinces of Córdoba, Corrientes, Salta yFormosa; outside Argentine territory S. leptocephalum is recorded in the late Pleistocene of Uruguay.S. bravardi Lydekker presents records in the provinces of BuenosAires during the Ensenadan (ca. 1 My - 0.4 My BP; early Pleistocene-middle Pleistocene) and in the Pleistocene of the provinceof San Luis, and (ii) S. leptocephalum Owen presents records during Bonaerian and Lujanian (ca. 0.4 My - 8.5 ky BP; middlePleistocene-early Holocene) in the Province of Buenos Aires, in the Lujanian of the provinces of Córdoba, Corrientes, Salta yFormosa; outside Argentine territory S. leptocephalum is recorded in the late Pleistocene of Uruguay.ca. 1 My - 0.4 My BP; early Pleistocene-middle Pleistocene) and in the Pleistocene of the provinceof San Luis, and (ii) S. leptocephalum Owen presents records during Bonaerian and Lujanian (ca. 0.4 My - 8.5 ky BP; middlePleistocene-early Holocene) in the Province of Buenos Aires, in the Lujanian of the provinces of Córdoba, Corrientes, Salta yFormosa; outside Argentine territory S. leptocephalum is recorded in the late Pleistocene of Uruguay.S. leptocephalum Owen presents records during Bonaerian and Lujanian (ca. 0.4 My - 8.5 ky BP; middlePleistocene-early Holocene) in the Province of Buenos Aires, in the Lujanian of the provinces of Córdoba, Corrientes, Salta yFormosa; outside Argentine territory S. leptocephalum is recorded in the late Pleistocene of Uruguay.S. leptocephalum is recorded in the late Pleistocene of Uruguay.","palabras_clave":"sloths|South America,|Quaternary|systematic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38568,"idioma_id":4,"titulo":"Increased Levels of Hyaluronic Acid in Bronchoalveolar Lavage from Patients with Interstitial Lung Diseases, Relationship with Lung Function and Inflammatory Cells Recruitment","resumen":"Purpose: Interstitial Lung Diseases (ILD) arecharacterized by inflammation and fibrosis. It described the role of hyaluronicacid (HA) as an immune-regulator. It is not known if HA contributes to the recruitment of inflammatory cells associated with ILD. If this hypothesis was correct, then concentrations of HA in bronchoalveolar lavage (BAL) should correlate with the severity of ILD. Methods: We collected BAL from 22 ILD patients and 15 control subjects. We determined HA and cytokine levels by ELISA. In vitro chemotaxis assays were performed by using a transwell system. Results: We found that ILD patients showed a significant increase in HA, IL-6 levels and the amount of cells in BAL compared to control subjects. We detected a significant positive correlation between HA and IL-6 levels (r =0.53 and p &lt; 0.001) and an inverse relationship between HA levels and diffusion capacity (r = &#8722;0.59, p &lt; 0.01). In vitro, HA induced migration of macrophages and monocytes through a CD44-dependent process. BAL from patients with ILD stimulated macrophage migration and this was abrogated by hyaluronidase. Conclusions: Our results support the hypothesis that HA contributes to the recruitment of monocytes towards the alveolar space, leading to exacerbation of lung inflammation in ILD patients.","palabras_clave":"HYALURONIC ACID|BRONCHOALVEOLAR LAVAGE|INTERSTITAL LUNG DESEASES|INFLAMMATORY CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38569,"idioma_id":4,"titulo":"Tuning the Molecular Sensitivity of Conductive Polymer Resistive Sensors by Chemical Functionalization","resumen":"Polyaniline thin films are chemically functionalized by nucleophilic addition of thiols beareing different functional groups: carboxylic, amine, -dodecyl and sulfonic. The modification is tested using FTIR and XPS spectroscopy. Then, the films are used as resistive sensors for different volatile organic compounds in a static measuring system. The sensitivity of conducting polymers to alcohols and heptane is strongly affected by the chemical functionalization of the materials. Polyaniline show an increasing signal when the chain length of different alcohols is increased. The incorporation of hydrophilic groups on the PANI chains seems to maintain the trend. On the other hand, the polymer modified with a long alkyl chain (PANI-DOT) show negative response for methanol and the signal increases up to propanol to decrease for longer chains. PANI-DOT show the largest signal for heptane of all polymers tested. Therefore, the functional group attached to the conductive polymer chain can be used to tune the molecular sensitivity of the resistive sensor","palabras_clave":"POLYMERS|SENSORS|FUNCTIONALIZACTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38570,"idioma_id":4,"titulo":"extracting kinetic parameters of aniline polymerization from thermal data of a batch reactor. simulation of the thermal behavior of a reactor","resumen":"The temperature-time profile in a cooled agitated batch reactor during aniline polymerization is monitored and fitted taking into account the heat production and heat dissipation. The rate equation includes the rate constant in absence of polymer (k1) and a rate constant in presence of polymer (k2). Using thermal parameters, such as the heat transfer coefficient and reaction enthalpy (measured experimentally) it is possible to fit the temperature-time profile with rate constants as adjustable parameters. Moreover it is possible to incorporate two constants a and b to the kinetics constants (k2, k1) to correct the influence of the concentration of the acid in the temperature time profile. The simulation shows an induction time in the reaction which increases when k1 and\/or k2 decrease and a temperature peak which height decreases with k2 and is not affected by k1. The temperature profile theoretically obtained are in complete agreement with the experimental temperature profile, ensure that the model proposed is adequate to evaluate PANI polymerization synthesis. The method proposed in this research allow to calculate both rate constants (k1 and k2) evaluating the experimental temperature-time curve for different synthesis conditions. Additionally, the reactor temperatures can be simulated to adjust the polymerization parameters to avoid degradation reactions.","palabras_clave":"POLYANILINE|POLIMERIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38571,"idioma_id":4,"titulo":"Acidic preconditioning improves the proangiogenic responses of endothelial colony forming cells","resumen":"Objective: Acidosis is present in several pathological conditions where vasculogenesis takes place including ischemia, tumor growth and wound healing. We have previously demonstrated that acidosis induces human CD34+ cell apoptosis. Considering that endothelial colony-forming cells (ECFC) are a subpopulation of CD34+ cells and key players in vasculogenesis, in the present study we investigated the effect of acidosis on the survival and functionality of ECFC.Approach and Results: ECFC, obtained by differentiation of human cord blood CD34+ cells in EGM2 for 14-21 days, were exposed at pH 7.4, 7.0 or 6.6. We found that acidosis failed to induce ECFC apoptosis and, although an early reduction in proliferation, chemotaxis, wound healing and capillary-like tubule formation was observed, once the medium pH was restored to 7.4, ECFC proliferation and tubulogenesis were augmented. SDF1-driven migration and CXCR4 surface expression were also increased. The maximal proangiogenic effect exerted by acidic preconditioning was observed after 6 h at pH 6.6. Furthermore, preconditioned ECFC showed an increased ability to promote tissue revascularization in a murine model of hind limb ischemia. Immunoblotting assays showed that acidosis activated AKT and ERK1\/2 and inhibited p38 pathways. Proliferation rises triggered by acidic preconditioning were no longer observed after AKT or ERK1\/2 inhibition, whereas p38 suppression not only mimicked but also potentiated the effect of acidosis on ECFC tubule formation abilities.Conclusions: These results demonstrate that acidic preconditioning greatly increases ECFC-mediated angiogenesis in vitro including ECFC proliferation, tubulogenesis and SDF1-driven chemotaxis and is a positive regulator of microvessel formation in vivo.","palabras_clave":"Endothelial colony-forming cells|vasculogenesis|acidic preconditioning|acidosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38572,"idioma_id":5,"titulo":"Edad, tamaño corporal en la madurez sexual, longevidad y potencial reproductivo de Leptodactylus latinasus y Leptodactylus mystacinus en un cultivo de soja y un bosque nativo del centro este de Argentina","resumen":"Population dynamics and skeletochronology in Leptodactylus latinasus and L.mystacinus in soybean fields from mideastern Argentina. We haveanalyzed diversity, richness of anurans in an agroecosystem (CS) and in anatural reserve Parque General San Martín (PGSM) as reference site (EntreRíos-Argentina). All individuals were captured, measured snout-vent length and released in situ. Leptodactylus mystacinus and Leptodactyluslatinasus had a phalange cut in order to determine its age. Twelve speciescorresponding to the families Bufonidae, Leptodactylidae, Odontophrynidae y Microhylidaewere registered. No statistical differences were found among the sites studied(p&gt;0.05) regarding species richness although dominance was significant(p&lt;0.05). Average age among sites was different in L. latinasus (p&lt;0.01), but not in L. mystacinus (p&gt;0.05). Sexual maturity was not observed in L. latinasus from CS while in L. mystacinus? it was reached at the ageof 3 inPGSM and 4 at CS. These results could indicate that individuals from PGSMachieve sexual maturity earlier in PGSM than in CS. Also, a higher longevityand average age in L. latinasus fromPGSM could suggest that environmental factors have an important role in agestructure of its populations but not in L.mystacinus. Further studies are needed to clarify if agroecosystems have arelevant effect over population demography.&nbsp;","palabras_clave":"amfibios |agroecoisistemas|osteocronobiología|madurez sexual"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38573,"idioma_id":4,"titulo":"Induction of micronuclei and nuclear  abnormalities in common toad tadpoles (Rhinella arenarum) treated with Liberty®  and glufosinate ammonium.","resumen":"The detection of micronucleated erythrocytes (ME) in blood represents a widely29 used method for the detection of chromosome damage by chemical water contaminants30 such as herbicides. We investigated the changes in some circulating blood cell31 parameters of common toad (Rhinella arenarum) tadpoles that were exposed to three32 sublethal doses (3.75, 7.5, and 15 mg\/L) of a commercial formulation of a glufosinateammonium(GLA)-based herbicide (Liberty®, LY®33 ) as well as to the corresponding34 active ingredient GLA for 48 and 96 h. The frequency of ME and other erythrocyte35 nuclear abnormalities (ENAs, i.e., lobed nuclei, binucleates or segmented nuclei, kidney36 shaped nuclei, notched nuclei, and picnotic nuclei) were evaluated and compared with37 positive (cyclophosphamide, CP, 40 mg\/L) and negative (dechlorinated tap water)38 controls. The results reported in the present study indicate that the exposure of R.arenarum tadpoles to LY® 39 and GLA induces a concentration-dependent increase in ME40 frequency. The ENAs frequency also increased significantly at 48 h in all the chemicalsassayed (CP, LY® 41 and GLA) respect to the negative control, whereas at 96 h,42 differences in ENAs were found between CP and GLA (7.5 mg\/L) respect to the43 negative control. Our study demonstrates that the commercial formulation of a GLA44based herbicide induces micronuclei formation in R. arenarum tadpoles, in contrast with45 the active ingredient. According to these results, the inert ingredients of the commercial46 formulation played an important role in the production of this genotoxic damage in47 erythrocytes of amphibian tadpoles.","palabras_clave":"micronuclei|erythrocyte nuclear abnormalities|herbicides"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38574,"idioma_id":5,"titulo":"Representaciones Sociales de la Historia: creencias, sentimientos e importancia de figuras de la historia argentina","resumen":"El proceso individual  de recordar está influenciado por el contexto social, que determina y  condiciona la manera en que se percibe e interpreta la realidad. El estudio de  las Representaciones Sociales de la historia (RSH) incluyen un sistema de  valores que ordenan el mundo y propone un código compartido de significaciones  (Farr, 1986). El objetivo general del presente trabajo es explorar en las RSH, en los personajes que un grupo de población general menciona como más  importantes al contar la historia argentina. Para ello se  administró una versión modificada del cuestionario diseñado por Liu et al.  (2005) a una muestra intencional compuesta por 262 participantes residentes en  la Ciudad de Buenos Aires. Los resultados obtenidos verifican la presencia de sesgos  bélicos y nostálgicos; la  evocación de figuras asociadas al liderazgo político, y un perfil de valores en  los participantes orientado a lo social por sobre lo  individual.","palabras_clave":"REPRESENTACIONES SOCIALES|HISTORIA ARGENTINA|VALORES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38575,"idioma_id":4,"titulo":"Development of naturally activated edible films with antioxidant properties prepared from red seaweed Porphyra columbina biopolymers","resumen":"The aim of this work was to study the physicochemical and antioxidant properties of phycobiliproteins?phycocolloids-based films, obtained from mixtures of two aqueous fractions extracted from Porphyra columbina red seaweed, one enriched in phycocolloids (PcF) and the other in phycobiliproteins (PF). Films with different ratios of PF:PcF (0, 25, 50, 75, 100% [w\/w]) and without plasticizer addition were prepared by casting. PcF films had excellent mechanical properties (tensile strength &#8764;50 MPa, elongation at break &#8764;3% and an elastic modulus &#8764;17.5 MPa). The addition of PF to formulations exerted a plasticizing effect on the PcF matrix, which was manifested in moisture content, water solubility and mechanical properties of the resulting films but not in its water vapour permeability. The antioxidant capacity (TEAC) of the PcF films was significantly increased by the addition of PF and a direct relationship between TEAC and the total phenolic compounds (r2 = 0.9998) and R-phycoerythrin (r2 = 0.9942) was observed.","palabras_clave":"EDIBLE FILMS|RED SEAWEEDS|PHYCOBILIPROTEINS|PHYCOCOLLOIDS|r-PHYCOERYTHRIN|ANTIOXIDANT PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38576,"idioma_id":4,"titulo":"Definability for Downward and Vertical XPath on Data Trees","resumen":"We study the expressive power of the downward and vertical  fragments of XPath equipped with (in)equality tests over data trees. We  give necessary and sufficient conditions for a class of pointed data trees  to be definable by a set of formulas or by a single formula of each of  the studied logics. To do so, we introduce a notion of saturation, and  show that over saturated data trees bisimulation coincides with logical  equivalence.","palabras_clave":"XPATH|DATA TREE|BISIMULATION|DEFINABILITY|FIRST-ORDER LOGIC|ULTRAPRODUCT|SATURATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38577,"idioma_id":4,"titulo":"Evaluation of the satiating properties of a nutraceutical product containing Garcinia cambogia and Ascophyllum nodosum extracts in healthy volunteers","resumen":"A nutraceutical product composed of a combination of Garcinia cambogia, L-carnitine and a seaweedextract of Ascophyllum nodosum has been recently developed. The aim of the present study was tocharacterize its effects on subjective satiety sensations and food preferences in healthy volunteers. In acrossover design, 28 subjects (21 females and 7 males, aged 31  5, BMI 22.6  1.7) were randomlyassigned to receive the active treatment (LIS) or placebo (PL) over one week. At the end of eachtreatment period, subjects were instructed to consume ad libitum a test meal. Food preferences andappetite sensations were evaluated by means of the Leeds Food Preferences Questionnaire and visualanalog scales, before and after meal, over three hours. There were no differences in energy intakebetween study groups. LIS was associated with a reduction in subjective hunger sensations (p ¼ 0.018)and to an increase in satiety (p ¼ 0.02) and fullness (p ¼ 0.01) ratings. The preference for high fat foodswas reduced after consuming the test meal in both study groups. There was a significant effect of LIStreatment on food explicit liking and implicit wanting, as evidenced by an increase in preference forsweet foods (relative to savory foods; p ¼ 0.03 and p ¼ 0.004, respectively), but no differences wereobserved regarding the preference for low or high fat foods (NS). These results provide proof of principlefor the satiating properties of a nutraceutical containing Garcinia cambogia, Ascophyllum nodosumextract and L-carnitine and suggest that it might be useful as an appetite modulator.","palabras_clave":"sss|fff"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38578,"idioma_id":4,"titulo":"Eutetrarhynchid trypanorhynchs from elasmobranchs off Argentina, including the description of Dollfusiella taminii sp. n. and Parachristianella damiani sp. n., and amended description of Dollfusiella vooremi (São Clemente et Gomes, 1989)","resumen":"During a parasitological survey of teleosts and elasmobranchs in the Argentine Sea, 3 species of eutetrarhynchids were collected from the batoids Myliobatis goodei Garman and Psammobatis bergi Marini, and the shark Mustelus schmitti Springer. The specimens collected from Mu. schmitti were identified as D. vooremi, whereas the specimens from My. goodei and Ps. bergi resulted in new species of Dollfusiella and Parachristianella, respectively. Dollfusiella taminii sp. n. from Ps. bergi is characterized by a distinct basal armature with basal swelling and a heteroacanthous homeomorphous metabasal armature with 7?9 falcate hooks per principal row. Parachristianella damiani sp. n. from My. goodei lacks a distinct basal armature, having 2?3 initial rows of uncinate hooks, a heteroacanthous heteromorphous metabasal armature with the first principal row of small hooks, followed by rows with 10?14 large hooks. This is the first record of Parachristianella in the southwestern Atlantic. The amended description of D. vooremi includes the detailed description of the tentacular armature, including SEM micrographs of all tentacular surfaces. This species is characterized by a basal armature consisting of rows of uncinate and falcate hooks, a basal swelling and a metabasal armature with billhooks on the antibothrial surface and uncinate hooks on the bothrial surface. The scolex peduncle of D. vooremi is covered with enlarged spinitriches. This species is restricted to carcharhiniform sharks, since the report of D. vooremi in Sympterygia bonapartii Müller et Henle off Bahía Blanca (Argentina) is dubious.","palabras_clave":"MYLIOBATIS GOODEI|PSAMMOBATIS BERGI|MUSTELUS SCHMITTI|TAPEWORMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38579,"idioma_id":4,"titulo":"Synthesis of Phenanthrenol Derivatives Through Polar Diels-Alder Reactions Employing Nitronaphthalenes and (E)-1-(Trimethylsilyloxy)-1,3- butadiene. Theoretical Calculations","resumen":"The cycloaddition reactions between dinitronaphthalenes and (E)-1-trimethylsilyloxy-1,3-butadiene produce nitrophenanthrenol derivatives as principal products. The primary adducts suffer the irreversible lost of nitrous acid and, consequently, the aromatization. In these reactions it is frequent to observe the presence of naphthalenyl-1H-pyrrole derivatives as a result of a hetero Diels-Alder process, which is competitive with the normal way. The global electrophilic character of the dienophile is responsible of these results. Other dienes (or dienophiles\/electrophiles) with electron donor substitution in C-1 show a different behavior in which the hetero Diels-Alder products prevail. In the series explored only the substrate 1-cyano-4-nitronaphthalene produces the naphthalenyl-1H-pyrrole derivative as principal product, probably as a consequence of its charge distribution. A combination between stereoelectronic effects in the electrophile and the type of substitution joint to the nucleophilicity of the diene is responsible of the results and regioselectivity observed in these polar cycloaddition reactions. In all the cases studied the regioselectivity expected by theoretical calculations corresponds with the ones obtained experimentally.","palabras_clave":"PHENANTHRENOLS|DIELS-ALDER REACTION |NITRONAPHTHALENES|ELECTROPHILES|THEORETICAL CALCULATIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38580,"idioma_id":4,"titulo":"Spatial and Seasonal Dynamic of Abundance and Distribution of Guanaco and Livestock: Insights from using Density Surface and Null Models","resumen":"Monitoring species abundance and distribution is a prerequisite when assessing species status and population viability, a difficult task to achieve for large herbivores at ecologically meaningful scales. Co-occurrence patterns can be used to infer mechanisms of community organization (such as biotic interactions), although it has been traditionally applied to binary presence\/absence data. Here, we combine density surface and null models of abundance data as a novel approach to analyze the spatial and seasonal dynamics of abundance and distribution of guanacos (Lama guanicoe) and domestic herbivores in northern Patagonia, in order to visually and analytically compare the dispersion and co-occurrence pattern of ungulates. We found a marked seasonal pattern in abundance and spatial distribution of L. guanicoe. The guanaco population reached its maximum annual size and spatial dispersion in spring-summer, decreasing up to 6.5 times in size and occupying few sites of the study area in fall-winter. These results are evidence of the seasonal migration process of guanaco populations, an increasingly rare event for terrestrial mammals worldwide. The maximum number of guanacos estimated for spring (25951) is higher than the total population size (10000) 20 years ago, probably due to both counting methodology and population growth. Livestock were mostly distributed near human settlements, as expected by the sedentary management practiced by local people. Herbivore distribution was non-random; i.e., guanaco and livestock abundances co-varied negatively in all seasons, more than expected by chance. Segregation degree of guanaco and small- livestock (goats and sheep) was comparatively stronger than that of guanaco and large-livestock, suggesting a competition mechanism between ecologically similar herbivores, although various environmental factors could also contribute to habitat segregation. The new and compelling combination of methods used here is highly useful for researchers who conduct counts of animals to simultaneously estimate population sizes, distributions, assess temporal trends and characterize multi-species spatial interactions.","palabras_clave":"Density surface model|Null models|Abundance|Spatial distribution|Large herbivores"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38581,"idioma_id":4,"titulo":"Quantitative trait loci affecting reproductive phenology in peach","resumen":"Background  The reproductive phenology of perennial plants in temperate climates is largely conditioned by the duration of bud dormancy, and fruit developmental processes. Bud dormancy release and bud break depends on the perception of cumulative chilling and heat during the bud development. The objective of this work was to identify new quantitative trait loci (QTLs) associated to temperature requirements for bud dormancy release and flowering and to fruit harvest date, in a segregating population of peach.   Results  We have identified QTLs for nine traits related to bud dormancy, flowering and fruit harvest in an intraspecific hybrid population of peach in two locations differing in chilling time accumulation. QTLs were located in a genetic linkage map of peach based on single nucleotide polymorphism (SNP) markers for eight linkage groups (LGs) of the peach genome sequence. QTLs for chilling requirements for dormancy release and blooming clustered in seven different genomic regions that partially coincided with loci identified in previous works. The most significant QTL for chilling requirements mapped to LG1, close to the evergrowing locus. QTLs for heat requirement related traits were distributed in nine genomic regions, four of them co-localizing with QTLs for chilling requirement trait. Two major loci in LG4 and LG6 determined fruit harvest time.   Conclusions  We identified QTLs associated to nine traits related to the reproductive phenology in peach. A search of candidate genes for these QTLs rendered different genes related to flowering regulation, chromatin modification and hormone signalling. A better understanding of the genetic factors affecting crop phenology might help scientists and breeders to predict changes in genotype performance in a context of global climate change.","palabras_clave":"PEACH|QTL|IMPROVEMENT|DORMANCY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38582,"idioma_id":4,"titulo":"INFILTRATION AND DRAINAGE ANALYSIS IN A HETEROGENEOUS SOIL BY  ELECTRICAL RESISTIVITY TOMOGRAPHY","resumen":"Petrocalcic horizons are a common feature of soils in many regions. As a result of their presence, the soils acquire a noticeable stratified profile that may severely restrict water infiltration. Therefore, assessing infiltration and drainage becomes a complex task due to the heterogeneous nature of this kind of soils. In the present study, infiltration and drainage were evaluated by means of electrical resistivity tomography (ERT), in a Paleudol soil with a petrocalcic horizon at 90 cm depth. A field infiltration test was carried out on an 11.2 m-long transect that was implemented with tensiometers and time domain reflectometry (TDR) probes. Successive measurements using ERT allowed determining resistivity changes as infiltration progressed. Resistivity values were converted into soil water content values by means of functions obtained after laboratory experiments. The soil water contents calculated were validated with the numerical modeling of pressure heads and with TDR water contents. The results showed soil horizon heterogeneities and the behavior of the preferential flow of water. These results further demonstrated the strong control that petrocalcic horizon heterogeneities exert on the water flow at field scale. Less indurated zones favored preferential flow to develop.","palabras_clave":"Infiltration|drainage|electric tomography"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38583,"idioma_id":4,"titulo":"Myeloid-derived suppressor cells are key players in the resolution of inflammation during a model of acute infection","resumen":"Myeloid-derived suppressor cells (MDSCs) are key players in the immune suppressive network. During acute infection with the causative agent of Chagas disease, Trypanosoma cruzi, BALB\/c mice show less inflammation and better survival than C57BL\/6 (B6) mice. In this comparative study, we found a higher number of MDSCs in the spleens and livers of infected BALB\/c mice compared with infected B6 mice. An analysis of the two major MDSCs subsets revealed a greater number of granulocytic cells in the spleens and livers of BALB\/c mice when compared with that in B6 mice. Moreover, splenic MDSCs purified from infected BALB\/c mice inhibited ConA-induced splenocyte proliferation. Mechanistic studies demonstrated that ROS and nitric oxide were involved in the suppressive activity of MDSCs, with a higher number of infected CD8+ T cells suffering surface-nitration compared to uninfected controls. An upregulation of NADPH oxidase p47 phox subunit and p-STAT3 occurred in MDSCs and infected IL-6 KO mice showed less recruitment of MDSCs and impaired survival. Remarkably, in vivo depletion of MDSCs led to increased production of IL-6, IFN-&#947;, and a Th17 response with very high parasitemia and mortality. These findings demonstrate a new facet of MDSCs as crucial regulators of inflammation during T. cruzi infection.","palabras_clave":"INFLAMMATION|MDSCs|NITRIC OXIDE |TRYPANOSOMA CRUZI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38584,"idioma_id":4,"titulo":"Antioxidant enzyme activities and gene expression patterns in peanut nodules during a drought and rehydration cycle","resumen":"Drought stress is one of the most important environmental factors that affect plant growth and limit biomassproduction. Most studies focus on drought stress development but the reversibility of the effects receives less attention.Therefore, the present work aims to explore the biological nitrogen fixation (BNF) of the symbiotic association betweenpeanut (Arachis hypogaea L.) and Bradyrhizobium sp. during a drought?recovery cycle with a focus on the response ofenzyme activity and gene expression of the antioxidant system. Peanuts exposed to drought stress had impaired BNF, asindicated by lower nitrogenase activity, and decreased leghaemoglobin content; the latter was reversed to control valuesupon rehydration. Previous results demonstrated that reactive oxygen species (O2 and H2O2) were accumulated asa consequence of drought stress, suggesting that nodules experience oxidative stress. In addition, marker transcriptsresponsive to drought, abscisic acid and H2O2 were upregulated. Increased transcript levels of glutathione reductase wereassociated with an increased enzyme activity but superoxide dismutase and glutathione S-transferase activities wereunchanged, despite upregulated gene transcription. In contrast, increased activity of ascorbate peroxidase (APX) wasunrelated with changesin cytosolic APXtranscript levels suggestingisogene specificity. In conclusion,the work exemplarilydemonstrates the efficient and dynamic regulation of antioxidant enzymes and marker compounds during drought cycling,which is likely to be a prerequisite for functional optimisation of nodule metabolism.","palabras_clave":"ANTIOXIDANT SYSTEM|ARACHIS HYPOGAEA|BIOLOGICAL NITROGEN FIXATION|OXIDATIVE STRESS|REACTIVE OXYGEN SPECIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38585,"idioma_id":5,"titulo":"Dispuestos a trabajar. Aproximación a la visión de los agentes estatales de un programa de empleo para jóvenes en Argentina","resumen":"El presente artículo propone un análisis de los discursos, diagnósticos y lógicas de funcionamiento  que estructuran el Programa Jóvenes con Más y Mejor Trabajo en un barrio popular  de Córdoba, Argentina. El texto indaga sobre la manera en la que este programa (a partir  de sus diferentes dimensiones e instancias) participa en la configuración de la ?cultura del  trabajo? de jóvenes de clases populares. A partir de esto, describimos los sentidos y reformulaciones  de algunos ejes conceptuales del programa y su puesta en práctica por agentes  estatales. De esta manera, mostramos el entrecruzamiento de la producción de legitimidades  del Estado (autoridad moral) y legitimidades de los beneficiarios del programa (mérito y  dignidad social), en un proceso móvil cuya regulación hegemónica lo constituye en marco  discursivo común para la diferenciación social.","palabras_clave":"cultura del trabajo|jóvenes|políticas de empleo|clases populares"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38586,"idioma_id":4,"titulo":"Intrastriatal 6-OHDA lesion differentially affects dopaminergic neurons in the ventral tegmental area of prenatally stressed rats","resumen":"Exposure to a variety of stressful events during the  last week of pregnancy in rats interferes with the correct progeny development,  which in turn leads to delays in motor development, impaired adaptation to  stressful conditions, altered sexual behaviour, learning deficits, neuronal  development and brain morphology. Many of these alterations have been  attributed to changes in dopamine (DA) neurotransmission and occur primarily in  the mesolimbic system. We  found that prenatally stressed offspring showed higher levels of cells  expressing tyrosine hydroxylase (TH) in the ventral tegmental area (VTA) and  that these cells were more susceptible to a neurochemical insult with  6-hydroxydopamine (6-OHDA) in adulthood. Moreover, prenatally stressed rats  presented differences in terms of the number and asymmetry of neuronal nitric  oxide synthase-expressing cells in the VTA and nucleus accumbens, respectively.  Similar to the results described for TH-expressing cells, the nitrergic systems  were differentially regulated after 6-OHDA lesion in control and prenatally  stressed rats. These results indicated that prenatal stress affects the  dopaminergic and nitrergic systems in the mesolimbic pathway. In addition, we  propose that the mesolimbic areas are more susceptible than the motor areas to  a neurochemical insult during adult life. ","palabras_clave":"RESTRAINT STRESS|LIMBIC AREAS|NEUROCHEMICAL INSULT|DOPAMINE|NITRIC OXIDE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38587,"idioma_id":4,"titulo":"Quantum non-Markovian behavior at the chaos border","resumen":"In this work we study the non-Markovian behavior of a qubit coupled to an environment in which the corresponding classical dynamics change from integrable to chaotic. We show that in the transition region, where the dynamics has both regular islands and chaotic areas, the average non-Markovian behavior is enhanced to values even larger than those in the regular regime. This effect can be related to the non-Markovian behavior as a function of the initial state of the environment, where maxima are attained at the regions dividing separate areas in classical phase space, particularly at the borders between chaotic and regular regions. Moreover, we show that the fluctuations of the fidelity of the environment?which determine the non-Markovianity measure?give a precise image of the classical phase portrait.","palabras_clave":"Mecánica Cuántica|No-Markovianidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38588,"idioma_id":5,"titulo":"Los programas de mano: una forma particular de la crítica de cine","resumen":"El despuntar de los años sesenta se encuentra con movimientos renovadores en el arte, y el cine no es ajeno a este clima. La movilización en el campo dela producción es paralela a la que se observa en la teoría y en la crítica. En Argentina, tiene lugar un fuerte impulso al cine que se entiende como arte. Este se expresa en diferentes espacios: se afianzan las revistas especializadas y los cine-clubes, surgen las salas de cine-arte, y los medios no especializados comienzan a otorgar al cine un lugar privilegiado en las áreas dedicadas al consumo cultural. El dossier intenta dar cuenta de las líneas críticas que se destacan en algunos medios que se ha considerado ponen más en evidencia las nuevas lecturas que recibe el cine.","palabras_clave":"CRÍTICA DE ARTES|METACRÍTICA|CINE|AÑOS 60"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38589,"idioma_id":4,"titulo":"Comparative effectiveness of two metronomic chemotherapy schedules-our experience in the preclinical field","resumen":"Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic.","palabras_clave":"Metronomic chemotherapy|Combined treatment|Cyclophosphamide|Doxorubicin|Celecoxib|Mammary adenocarcinoma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38590,"idioma_id":4,"titulo":"A MAMMARY ADENOCARCINOMA MURINE MODEL SUITABLE FOR THE STUDY OF CANCER IMMUNOEDITING","resumen":"Cancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune system throughout tumor development. Animal models are useful tools for studying diseases such as cancer. The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi? and CBi\/L inbred mice lines.","palabras_clave":"inmunoedición tumoral|cáncer de mama|modelos animales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38591,"idioma_id":4,"titulo":"A MODEL BASED IN THE RADIUS OF VESICLES TO PREDICT THE NUMBER OF UNILAMELLAR LIPOSOMES","resumen":"In    particulate  systems  such  as  liposomes,  concentration  units  are    not  enough  to describe  the  drug  distribution,  as  suspensions    are  not  homogeneous.  In  certain  in  vitro assays, exposure to   different number of particles introduces an extra variable regarding to   contact phenomena. The aim is to achieve a rapid estimation of the   number of unilamellar liposomes in a suspension. A simple mathematical   method was developed; variables were the area and molecular weight of    lipids, and  the mean size of  the  liposomes. Unilamellar liposomes   were prepared. Size was determined by dynamic  light scattering, and   then the number of particles were determined by tunable resistive pulse   sensing. There was about a 90% coincidence between the theoretical   results and the number of counted liposomes. This model  could be   useful  for  interpretation of  in  vitro experiments, when  results    could depend on the distribution of actives into different quantities of   liposomes","palabras_clave":"LIPOSOMES|UNILAMELLAR|RADIUS|EQUATION|TPRS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38592,"idioma_id":4,"titulo":"The effect of constant darkness and circadian resynchronization on the recovery of alcohol hangover","resumen":"Alcohol hangover (AH) is a particular state after binge-like drinking. AH begins when ethanol is absent  in plasma and is characterized by a cluster of physical and psychological symptoms. Alcohol disrupts  circadian patterns of behavioral and physiological parameters; however, the involvement of circadian  clock on the recovery of AH was not explored. Our aim was to study the effect of continuous darkness  and the possible involvement of the circadian clock in the recovery time of neuromuscular impairment  and anxiety related-behavior due to AH. Male Swiss mice were habituated to 12:12 L:D or continuous  darkness. Each group was injected i.p. either with saline (control group) or with ethanol (3.8 g\/kg BW)  (hangover group). Motor performance and anxiety phenotype were evaluated at a basal point (ZT0) and  every 2 h up to 20 h after blood alcohol levels were close to zero (hangover onset). A third group was  subjected to a phase advance during which a hangover episode was induced and behavioral tests were  carried out for each group of treatment and resynchronization day. Constant darkness resulted to be  in a faster recovery of both motor and anxiety impairments in AH compared with the recovery pattern  observed under normal light?dark conditions. Mice suffering from a phase shift exhibited behavioral  disruptions due to both AH and phase advance. Results indicated that a synchronized circadian clock is  necessary for an adequate recovery of alcohol hangover symptoms","palabras_clave":"ALCOHOL HANGOVER|CIRCADIAN CLOCK|NEUROMUSCULAR COORDINATION|ANXIETY-LIKE BEHAVIOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38593,"idioma_id":4,"titulo":"Effect of melatonin on motor performance and brain cortex mitochondrial function during ethanol hangover","resumen":"Abstract?Increased reactive oxygen species generationand mitochondrial dysfunction occur during ethanol hangover.The aim of this work was to study the effect of melatoninpretreatment on motor performance and mitochondrialfunction during ethanol hangover. Male mice received melatoninsolution or its vehicle in drinking water during 7 daysand i.p. injection with EtOH (3.8 g\/kg BW) or saline at theeighth day. Motor performance and mitochondrial functionwere evaluated at the onset of hangover (6 h after injection).Melatonin improved motor coordination in ethanol hangovermice. Malate?glutamate-dependent oxygen uptake wasdecreased by ethanol hangover treatment and partially preventedby melatonin pretreatment. Melatonin alone induceda decrease of 30% in state 4 succinate-dependent respiratoryrate. Also, the activity of the respiratory complexeswas decreased in melatonin-pretreated ethanol hangovergroup. Melatonin pretreatment before the hangover preventedmitochondrial membrane potential collapse andinduced a 79% decrement of hydrogen peroxide productionas compared with ethanol hangover group. Ethanol hangoverinduced a 25% decrease in NO production. Melatoninalone and as a pretreatment before ethanol hangover significantlyincreased NO production by nNOS and iNOS as comparedwith control groups. No differences were observed innNOS protein expression, while iNOS expression wasincreased in the melatonin group. Increased NO productionby melatonin could be involved in the decrease of succinatedependentoxygen consumption and the inhibition of complexIV observed in our study. Melatonin seems to act asan antioxidant agent in the ethanol hangover condition butalso exhibited some dual effects related to NO metabolism. 2014 IBRO. Published by Elsevier Ltd. All rights reserved.Key words: melatonin, ethanol hangover, motor coordination,mitochondrial function, mitochondrial membrane potential,oxidative stress.","palabras_clave":"ALCOHOL HANGOVER|BRAIN CORTEX MITOCHONDRIA|FREE RADICALS|MELATONIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38594,"idioma_id":4,"titulo":"The double slit experience with light from Feynman´s Sum of Multiple Paths viewpoint","resumen":"Abstract  This paper presents an analysis of the double slit experience with light, by using concepts of Feynman ?Sum of Multiple Paths? method of quantum mechanics. The advantages of this formulation for the teaching of basic aspects of quantum mechanics in the secondary school are analyzed.","palabras_clave":"Quantum Mechanics Teaching|Secondary school|Physics Didactic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38595,"idioma_id":4,"titulo":"An assessment of growth ring identification in subtropical forests from northwestern Argentina","resumen":"Most subtropical forests in South America are located in regions with a marked seasonality in precipitation, which may induce the formation of annual bands in woody species. Due to the lack of precise information on tree-ring visibility, we evaluated the wood characteristics of 37 tree species in the subtropical Yungas and Chaco forests from northwestern (NW) Argentina. Anatomical features associated with the delimitation of growth bands were examined to establish the presence of tree rings. Different forest types reflect the precipitation gradients and wood anatomical features vary accordingly. Characteristics of wood structure are closely related to the dominant climatic patterns of each forest, revealing a common pattern of anatomical arrangements in terms of water transport and safety. In the Chaco and transitional forests, ring boundaries are related to marginal parenchyma whereas in montane forests growth ring boundary is mostly associated with the presence of thicker fibers at the end of the ring. The largest proportion of species with clearly marked growth rings occurs in the montane forest type of NW Argentina. Clear growth rings is a requisite for dendrochronological applications, hence the present work represents the first regional attempt to address the potential of subtropical species in South America to be used in dendrochronological studies.","palabras_clave":"Tree rings|Wood anatomy|Montane forests|Transitional forests|Chaco|Yungas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38596,"idioma_id":4,"titulo":"The genetic diversity of wild rescuegrass is associated with precipitation levels","resumen":"Bromus catharticus Vahl, also known as rescuegrass, is&nbsp; indigenous to the Pampean region of Argentina. In recent&nbsp; decades, the production of this forage species has increased&nbsp; dramatically around the humid temperate regions of the&nbsp; world. However, since no public collection of wild&nbsp; rescuegrass is yet available, the genetic diversity of this&nbsp; species remains unclear. The aim of this study was to&nbsp; present and analyze a novel collection of wild rescuegrass.&nbsp; To this end, we investigated the genetic diversity of 67&nbsp; accessions of wild rescuegrass, by analyzing 17 polymorphic&nbsp; SSR markers by capillary electrophoresis. These molecular&nbsp; markers allowed us to detect a total of 130 alleles. The&nbsp; number of alleles per locus varied between 2 and 23, and the&nbsp; values of polymorphic information content ranged from 0.07&nbsp; to 0.36. The genetic diversity analysis showed that the&nbsp; accessions can be divided into two main groups associated&nbsp; with different precipitation levels, showing the existence&nbsp; of two distinct rescuegrass populations adapted to humid and&nbsp; semi-arid environments. The accessions derived from the&nbsp; humid environments contributed 96.1% of alleles suggesting a&nbsp; humid origin of rescuegrass. Finally, the public germplasm&nbsp; collection of rescuegrass represents an ideal material for&nbsp; the breeding community to improve cultivars for extended&nbsp; environments. ","palabras_clave":"SSR MARKERS|GENETIC DIVERSITY|FLOW CYTOMETRY|RESCUEGRASS|GENETIC RESOURCES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38597,"idioma_id":4,"titulo":"Artificial microRNAs as antiviral strategy to FMDV: structural implications of target selection","resumen":"RNA&nbsp; interference&nbsp; (RNAi)&nbsp; appears&nbsp; as&nbsp; a&nbsp; promising&nbsp; strategy&nbsp; to&nbsp; control&nbsp; virus&nbsp; replication.&nbsp; While&nbsp; the&nbsp; antiviralpower&nbsp; of&nbsp; short-hairpin&nbsp; RNAs&nbsp; or&nbsp; small-interfering&nbsp; RNAs&nbsp; against&nbsp; FMDV&nbsp; has&nbsp; been&nbsp; demonstrated&nbsp; widely,safer&nbsp; RNAi&nbsp; effectors&nbsp; such&nbsp; as&nbsp; artificial&nbsp; microRNAs&nbsp; (amiRs)&nbsp; have&nbsp; not&nbsp; been&nbsp; evaluated&nbsp; extensively.&nbsp; In&nbsp; thiswork,&nbsp; transgenic&nbsp; monoclonal&nbsp; cell&nbsp; lines&nbsp; constitutively&nbsp; expressing&nbsp; different&nbsp; amiRs&nbsp; targeting&nbsp; FMDV&nbsp; 3Dcoding&nbsp; region&nbsp; or&nbsp; 3UTR&nbsp; were&nbsp; established.&nbsp; Certain&nbsp; cell&nbsp; lines&nbsp; showed&nbsp; an&nbsp; effective,&nbsp; sequence-specificamiR-mediated&nbsp; silencing&nbsp; activity&nbsp; that&nbsp; was&nbsp; accomplished&nbsp; by&nbsp; degradation&nbsp; of&nbsp; the&nbsp; target&nbsp; mRNA,&nbsp; as&nbsp; demonstrated&nbsp; in&nbsp; co-transfection&nbsp; experiments&nbsp; of&nbsp; reporter&nbsp; genes&nbsp; fused&nbsp; to&nbsp; FMDV&nbsp; target&nbsp; sequences.&nbsp; However,FMDV&nbsp; replication&nbsp; in&nbsp; these&nbsp; amiR-expressing&nbsp; cells&nbsp; was&nbsp; affected&nbsp; barely.&nbsp; Experiments&nbsp; aimed&nbsp; at&nbsp; elucidatingthe&nbsp; cause&nbsp; of&nbsp; RNAi&nbsp; failure&nbsp; demonstrated&nbsp; limited&nbsp; accessibility&nbsp; of&nbsp; the&nbsp; targeted&nbsp; region&nbsp; in&nbsp; the&nbsp; molecular&nbsp; environment&nbsp; of&nbsp; the&nbsp; viral&nbsp; RNA.&nbsp; Since&nbsp; RNAi&nbsp; is&nbsp; mediated&nbsp; by&nbsp; large-dimension&nbsp; silencing&nbsp; complexes&nbsp; containing&nbsp; thesiRNA&nbsp; and&nbsp; not&nbsp; simply&nbsp; by&nbsp; a&nbsp; linear&nbsp; oligonucleotide,&nbsp; we&nbsp; propose&nbsp; that&nbsp; target&nbsp; selection&nbsp; should&nbsp; consider&nbsp; notonly&nbsp; the&nbsp; local&nbsp; RNA&nbsp; structure&nbsp; but&nbsp; also&nbsp; the&nbsp; global&nbsp; conformation&nbsp; of&nbsp; target&nbsp; RNA.","palabras_clave":"Artificial microRNAs|Antiviral|FMDV|RNA structure"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38598,"idioma_id":4,"titulo":"Environmental fate of Trifluralin, Procymidone , and Chlorpyrifos in small horticultural production units in Argentina","resumen":"Abstract Pesticide biodegradation was studied insoil samples of a representative small periurban productionunit (Moreno District, Argentina). The meanperiods required for the 50% dissipation of chlorpyrifos(16 days±1 day), procymidone (3.7 days±0.6 day), andtrifluralin (3.6 days±0.6 day) were significantly lowerthan those measured for reference soil samples of aclose location, using doses similar to the manufacturer?srecommendation. A preliminary screeningscheme for pesticide-degrading bacteria on horticulturalsoil allowed the isolation of nine culturable bacterialstrains, eight of which belonged to Pseudomonas genus.In order to consider the influence of the variability ofsoil properties on the biodegradation results, humidity,organic matter, conductivity, pH, water retention volume,density, respiration, and total phosphorous contentwere studied for different soil samples, finding no significantdifferences in the performed analysis. Overall,although the horticultural activity alters the natural soil,pesticide contamination effects could be reversed by theautochthonous microbial community","palabras_clave":"environment|fate|chlorpyrifos|procymidone"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38599,"idioma_id":4,"titulo":"Involvement of PI3K\/Akt and p38 MAPK in the induction of COX-2 expression by bacterial lipopolysaccharide in murine adrenocortical cells","resumen":"Previous studies from our laboratory demonstrated the involvement of COX-2 in the stimulation of steroid production by LPS in murine adrenocortical Y1 cells, as well as in the adrenal cortex of male Wistar rats. In this paper we analyzed signaling pathways involved in the induction of this key regulatory enzyme in adrenocortical cells and demonstrated that LPS triggers an increase in COX-2 mRNA levels by mechanisms involving the stimulation of reactive oxygen species (ROS) generation and the activation of p38 MAPK and Akt, in addition to the previously demonstrated increase in NF&#954;B activity. In this sense we showed that: (1) inhibition of p38 MAPK or PI3K\/Akt (pharmacological or molecular) prevented the increase in COX-2 protein levels by LPS, (2) LPS induced p38 MAPK and Akt phosphorylation, (3) antioxidant treatment blocked the effect of LPS on p38 MAPK phosphorylation and in COX-2 protein levels, (4) PI3K inhibition with LY294002 prevented p38 MAPK phosphorylation and, (5) the activity of an NF&#954;B reporter was decreased by p38 MAPK or PI3K inhibition. These results suggest that activation of both p38 MAPK and PI3K\/Akt pathways promote the stimulation of NF&#954;B activity and that PI3K\/Akt activity might regulate both p38 MAPK and NF&#954;B signaling pathways. In summary, in this study we showed that in adrenal cells, LPS induces COX-2 expression by activating p38 MAPK and PI3K\/Akt signaling pathways and that both pathways converge in the modulation of NF&#954;B transcriptional activity.","palabras_clave":"COX|MAPK"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38600,"idioma_id":5,"titulo":"Physaloptera maxilaris (Molina 1860) en Conepatus chinga (Zorrino común. Molina1782)capturado en Hilario Ascasubi, Provincia de Buenos Aires. Argentina.","resumen":"El Physaloptera maxilaris (Spirurida: Physalopteridae) es un nematodo que parasita elestómago de anfibios, reptiles,aves y una gran variedad de mamíferosinsectívoros y omnívoros en todo el mundo. El objetivo de este trabajo es describir la infección con P. maxilaris en un Conepatus chinga capturado en Ascasubi,provincia de Buenos Aires, Argentina. Desde el interior del estómago, se recolectó un total de 375 nematodos en diferentes etapas de desarrollo. Las muestras se identificaron como P. maxilarisen base a características morfológicas,tales como disposición cefálica; distancia de la vulva al extremo anterior de lahembra; número, tamaño y posiciónde las papilas caudales en machos; ornamentación cuticularde la parte ventral de la cola de correo; forma y tamañode espículas. ","palabras_clave":"PHYSALOPTERA MAXILARIS|CONEPATUS CHINGA|ZORRINO COMUN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38601,"idioma_id":5,"titulo":"Que es lo nuevo en la evolución morfologica?","resumen":"En este trabajo presentamos una revisión de conceptos y definiciones muy usados en estudios de Morfología Comparada, Biología Evolutiva y Evolución del Desarrollo (Evo-Devo). Para ello, partimos de información publicada sobre la variación morfológica de un linaje monofilético de anuros, los Ceratophryidae. Utilizamos el conjunto de apomorfías morfológicas propuestas para diagnosticar esta familia (formada por Ceratophrys, Chacophrys y Lepidobatrachus) y sus agrupaciones como casos de análisis. Distinguimos procesos evolutivos con consecuencias morfológicas (reducción, pérdida, reversión, aparición, duplicación), el origen de la variación(heterocronía, heterotopía, heterometría y heterotipia) y la novedad morfológica en sentido estricto. Desde la perspectiva de la Evolución del Desarrollo, analizamos el cambio de función y la aparición de morfologías únicas y viables en el linaje de los Ceratophryidae. La reducción de las diferencias morfológicas, fisiológicas y&nbsp; ecológicas entre larvas y adultos en Lepidobatrachus hacen de este un excelente organismo para aprender y discutir conceptos clásicos y novedosos con enfoques integrados desde diferentes disciplinas de trabajo (morfología, genética del desarrollo,ecología, fisiología).","palabras_clave":"NEOFORMACIÓN|VARIACIÓN|NOVEDAD|MORFOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38602,"idioma_id":4,"titulo":"Exposure variability of fosfomycin administered to pigs in food or water: Impact of social rank","resumen":"The aim of this trial was to document the effect of social rank on the internal exposure of pigs  54 to an antibiotic administered either in food or in drinking water in a commercial setting. Prior  55 to performing a farm-based study, conventional pharmacokinetic studies to validate  56 fosfomycin as a probe for the present investigation were carried out to interpret the disposition  57 of this antibiotic when administered in two different vehicles: water and food.","palabras_clave":"Administration in foodwater|Exposure variability|Fosfomycin|Pigs|Social rank"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38603,"idioma_id":4,"titulo":"Plasticity of altruistic behavior in children","resumen":"The present study investigates the plasticity of altruistic behavior in children, analyzing the effect of a short intervention on 6-7 year olds. After a 10-session intervention performed in a school context, altruism significantly increased. The intervention, which included relaxation practices, cooperative activities and emotional security priming, positively modulated altruistic behavior in children, beyond reciprocation and reputation. The experiences of collaborating, feeling emotional security and attaining moments of relaxation increased participants? awareness of themselves and of others, favoring the emergence of intrinsic altruism. These results are in line with our hypothesis that altruism is an embodied human resource, highly susceptible to experience within social contexts.","palabras_clave":"ALTRUISM|ATTACHMENT SECURITY|MIND-BODY INTEGRATION|EMBODIMENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38604,"idioma_id":4,"titulo":"Stress management in children: a pilot study in 7-9 year olds","resumen":"Objective:  At present, school-age children suffer high levels of chronic stress that could produce potentially long-lasting effects. The aim of this pilot study was to evaluate the effects of mind-body integration practices and cooperative activities on stress levels and social interaction in 7- to 9-year-old children.  Methods:  We performed an intervention program once a week during 2 months in which children performed mind-body integration practices and cooperative activities.  Results:  Our findings showed that these practices reduced cortisol levels and increased social connectedness. Moreover, we found that most of the children used the learned mind-body integration practices in stressful situations in their homes, even 5 months after the intervention.  Conclusions:  Our results demonstrated the positive impact of these helpful tools and the great plasticity of children´s behavior, which enabled them to incorporate healthy habits. Overall, the intervention enhanced health at an individual level and favored social network diversity at a group level. Our research illustrates how children can incorporate techniques that help them cope with stressful moments and reveals the effectiveness of this experience in reducing cortisol levels. This study contributes to the understanding of how mind-body integration practices and social connectedness can be helpful in reducing chronic stress, a topic that, to the best of our knowledge, has been little studied in children.","palabras_clave":"CHILDREN'S CHRONIC STRESS|SALIVARY CORTISOL|STRESS COPING|MIND-BODY INTEGRATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38605,"idioma_id":5,"titulo":"Estrategias argumentativas en niños pequeños: Un estudio a partir de las disputas durante el juego en contextos escolares","resumen":"En este trabajo se pone a prueba un sistema de categorías para analizar las estrategiasargumentativas que despliegan niños en situaciones de juego en el contexto educativo. Se indaga si el sistema resulta adecuado para describir y evaluar las estrategias argumentativas de niños de 3, 4 y 5 años en el contexto del jardín de infantes. El estudio empírico se desarrolla a partir de la observación de interacciones de niños en situaciones naturales de juego en jardines de infantes de la Ciudad de Buenos Aires. El estudio ha permitido concluir la validez del sistema para contextos institucionales. Asimismo, el análisis muestra que los niños producen mayormente expresiones de oposición argumentativa sin desplegar argumentos estructurados (razón-conclusión), lo que podría ser característico de una fase protoargumentativa, y que entre los niños de 5 años se observa un uso más recurrente del esquema argumentativo de apelación a la mayoría.Revista indexada  en: Social Sciences  Citation Index y Arts &amp; Humanities - Citation Index - Thomson Scientific,  ISI web of Knowledge; Scientific Electronic Library Online ? Cielo; SciVerse  Scopus; Internationale Biblio¬graphie der geistes- und sozialwissenschaftlichen  Zeitschriftenliteratur ? IBZ; Internationale Bibliographie der Rezensionen  geistes- und sozialwissenschaftlicher Literatur ? IBR; Modern Language  Association; International Bibliography ? MLA; LATINDEX  ","palabras_clave":"ARGUMENTACIÓN|JUEGO|NIÑOS|OPOSICIÓN|PUNTO DE VISTA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38606,"idioma_id":4,"titulo":"Factors reflecting children's use of temporal terms as a function of social group","resumen":"The study analyses the relationship between the temporal terms used by four year-old children from different socio-economic backgrounds - marginalized urban neighborhoods and middle-income families- and the use of these terms in the spontaneous situations in which they participate in family and community contexts. The analysis assumes that the child develops knowledge about temporal expressions as they are used by others and as the child uses them herself (Nelson 2007; Tomasello 2003). Findings show that children from marginalized urban neighborhoods use fewer temporal terms than children from middle-income backgrounds. These differences correlate with differences in the input of both groups. The analysis shows differences in the interactional and discursive patterns of use of the terms in the homes of both groups of children.  Publicación indexada en: Language Abstracts, LLBA, MLA, LB, Scopus.","palabras_clave":"TEMPORAL VOCABULARY|LEXICAL INPUT|SOCIOCULTURAL DIFFERENCES|INTERACTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38607,"idioma_id":4,"titulo":"Determination of the total and extractable fraction of Ni in lake sediments and natural waters of San Luis (Argentina) by FAAS using a simple solid phase extraction system","resumen":"An on-line nickel preconcentration and determination system implemented with flame atomic absorption spectrometry (FAAS) was developed. The nickel was retained on the inner walls of a column filled with ethyl vinyl acetate (EVA). The EVA was used as sorbent material for on-line solid-phase extraction (SPE) in the absence of complexing agent. The effects of sampling volume, elution conditions, sample pH and flow rate on the Ni extraction were studied. The analytical efficiency parameters obtained with this methodology were: enrichment factor (EF) of 46 times for a preconcentration time of 120s, the limit of detection (LOD) was 3.78&#956;gL-1, and the precision for six replicate determinations (repeatability conditions) at 20&#956;gL-1 Ni concentration was 4.38% relative standard deviation. The sampling frequency for the proposed system was about 20samples\/h. The optimized procedure was applied to the determination of Ni in natural water and lake sediment samples. © 2014 Elsevier B.V.","palabras_clave":"EVA|FAAS|LAKE SEDIMENTS|NICKEL DETERMINATION|ON-LINE PRECONCENTRATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38608,"idioma_id":4,"titulo":"Children Interactions in Literacy Tutoring Situations.  A Study with Urban Marginalized Populations in Argentina","resumen":"The study analyzed the conversational exchanges through which child tutors mediated literacy abilities and knowledge with young children in the framework of the project ?From Child to Child: A Tutor-Child   Literacy Program,? that is being conducted in Buenos Aires, Argentina. The analysis considered the conversational moves deployed by both participants in the dyad, as well as the relationship between the   tutor and the tutee. Likewise, it examined longitudinal variations in the interactions registered between the first tutoring sessions and the tutoring sessions that occurred after one year of the program. The   tutoring sessions were video-taped and the different conversational moves deployed by the tutor and tutee were analyzed using an especially developed system of categories. Subsequently, the distribution of   the categories of the tutee and tutor?s interactional moves in the corpus was analyzed quantitatively.   Results showed significant longitudinal differences in the quantity of conversational moves: the tutors and the tutees increased their participation in the performance of the activities. The results demonstrated an increase in all the conversational moves the tutors utilized to promote the learning of the younger child tutee and a decrease in those conversational moves that do not promote learning.","palabras_clave":"child tutors|conversational movements|early literacy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38609,"idioma_id":4,"titulo":"Cross transferability of SSR markers to endangered Cedrela species that grow in Argentinean subtropical forests, as a valuable tool for population genetic studies","resumen":"Species of Cedrela with a high economic value from Northwest and Northeastern Argentina  are severely exploited. This work evaluates whether 51 nuclear SSRs, developed to study  phylogenetically close species in the Meliaceae family (Cedrela odorata, Cedrela fissilis,  Swietenia humilis and Swietenia macrophylla), can be used to study C. fissilis, Cedrela balansae,  Cedrela saltensis and Cedrela angustifolia. A 62.8% of the total of 194 SSRs\/species  combinations showed a successful, homologous and cross-species amplification. As expected,  a great success in SSRs transferability among Cedrela species was observed.  Twenty-one screened SSRs showed a successful amplification pattern in all target species  and many of them were polymorphic (9, 13, 13 and 7 SSRs for C. fissilis, C. balansae, C. saltensis and C. angustifolia, respectively). The high number of evaluated SSRs from the  Cedrela genus and Meliaceae family, allowed us to obtain a suitable set of validated  markers that are highly variable and easily scored, and also identify those which were less  sturdy. We were able to retain a useful set of markers for three of the target species, but  not for C. angustifolia. This could be due to its greater phylogenetic and morphological  distances to the other three species. The lack of SSRs developed for our target species,  transforms the transferred SSRs reported here in a valuable tool to monitor the genetic  consequences of forest overexploitation on Cedrela species.","palabras_clave":"CEDRELA|MELIACEAE|MICROSATELLITE|TRANSFERABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38610,"idioma_id":4,"titulo":"Optimization of Fe-15Mn-5Si-9Cr- 5Ni Shape Memory Alloy","resumen":"We investigated whether Fe-Mn-Si shape memory alloys could be manufactured into machine parts and devices, in particular pipe and shaft couplings. Accounting for the optimal parameters affecting shape memory properties, i.e., the chemical composition, the amount of processing deformation, the annealing temperature, and the correlation between the reversibility of the martensitic transformation and the conditions of the microstructure (particularly the role of crystal defects), we found that maximum recovery in a Fe-15Mn-5Si-9Cr-5Ni alloy is achieved by rolling at 800 C followed by annealing at 650 C. Furthermore, we investigated certain properties that establish technological feasibility limits to industrial production, including alloy weldability and mechanical response. Bending and tensile specimen tests determinate the expected behavior of parts joined by welding. We also developed an original process to produce the couplings. The degree of shape recovery of the couplings manufactured by this method depends on the annealing temperature after welding. The couplings annealed at 800 C recovered 83% of a 3.6% permanentdiametrical expansion.","palabras_clave":"Fe-Mn-Si|SHAPE|MEMORY|COUPLINGS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38611,"idioma_id":4,"titulo":"Differences in sperm storage and remating propensity between adult females of two morphotypes of the Anastrepha fraterculus (Diptera: Tephritidae) cryptic species complex","resumen":"The South American fruit fly, Anastrephafraterculus, is a complex of cryptic species composed by at least sevenmorphotypes. Some of them, such as thePeruvian and Brazilian 1 morphotypes (which includes Argentinean populations),exhibit strong pre-copulatory isolation, yet it is possible to obtainheterotypic crosses when forcing copulation of adults under laboratoryconditions. The cross involving Peruvian males and Argentinean females producesF1 offspring with reduced viability in terms of egg hatch. This lowhatchability could be caused by a reduced amount of sperm transferred to and storedby females mated with heterotypic males, which in turn could affect theirpost-copulatory behavior. To test these hypotheses, we investigated spermtransfer and female mating and remating behaviour for homotypic and heterotypiccrosses between adults of two morphotypes (Brazilian 1 [Argentina] and Peruvian[Peru]) of the A. fraterculus crypticspecies complex. As reported before, Argentinean males and females matedearlier in the day than the other three mating combinations. Peruvian femalesengaged in shorter copulation times than Argentinean females. Peruvian femalestended to store smaller quantities of sperm than Argentinean females, andalmost a half of the crosses involving Argentinean males and Peruvian femaleswere unsuccessful (no sperm transfer). However, there was no evidence that the cross betweenPeruvian males and Argentinean females resulted in storage of a criticallysmall amount of sperm. Argentinean females were more willing to remate than Peruvian females,irrespective of male morphotype, but latency to remating was not affected bymale or female morphotype. This study shows that mating behavior differs between some of the A. fraterculus complex morphotypes, with femalebut not male morphotype determing female likelihood to remate.","palabras_clave":"Sexual isolation|South American fruit fly|remating behaviour|cryptic species complex"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38612,"idioma_id":4,"titulo":"Electrochemical synthesis of hydrogen peroxide with a three-dimensional rotating cylinder electrode","resumen":"BACKGROUND: This work analyzes the synthesis of H2O2 from dilute NaOH solutions under 0.1 MPa O2 using a batch reactor with a three-dimensional rotating cylinder electrode. The centrifugal force produces a radial co-current flow of the gas and liquid phases. Thus, good mass transfer conditions are achieved and the O2 reduced to H2O2 is easily replenished in the liquid phase.                                          &nbsp;                          RESULTS: Experiments with a glassy carbon rotating disc electrode identified 0.5 mol L-1 NaOH at 30ºC as suitable operating conditions. Galvanostatic experiments with three-dimensional rotating electrodes concluded that the best performance was obtained for a reticulated vitreous carbon structure of 100 ppi, at 40 mA cm-2 of macrokinetic current density and 1000 rpm rotation speed. Long term experiments showed 79% current efficiency and 8.2 kWh kg-1 specific energy consumption until 6 h of electrolysis, with 8.4 g L-1 H2O2 concentration. However, the current efficiency decreases at higher electrolysis times and consequently the specific energy consumption is increased. Thus after 10 h electrolysis the concentrations were H2O2 10.4 g L-1 and NaOH 1.41 mol L-1.                                                      &nbsp;                          CONCLUSION: A three-dimensional rotating cylinder electrode with co-current oxygen and liquid flows inside the structure showed promising performance for H2O2&nbsp; production.                          ","palabras_clave":"HYDROGEN PEROXIDE|ELECTROCHEMICAL REACTOR|THREE-DIMENSIONAL ELECTRODE|OXYGEN REDUCTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38613,"idioma_id":4,"titulo":"Age-distribution and genotype-phenotype correlation for N-acetyltransferase in Argentine children under isoniazid treatment","resumen":"Metabolic clearance of isoniazid (INH) may be up to 10 times faster   in individuals who are rapid acetylators compared with slow acetylators.   In addition, the acetylation phenotype has been suggested to change   with age. A better knowledge of the age distribution of the acetylation   genotype and phenotype in children requiring INH for tuberculosis   treatment or prevention could be important to optimize safety and   efficacy of INH use.  OBJECTIVES:   The aim of the present   study was to evaluate the genotype and phenotype of NAT2 in an   Argentinean pediatric population rom Buenos Aires. In addition, we   wanted to describe genotype-phenotype correlation, as well as its   distribution at different ages.  METHODOLOGY:   NAT2   genotyping was performed by RFLP technique, searching for common   polymorphisms. Acetylisoniazid and isoniazid concentrations were   measured by HPLC and NAT2 phenotype was defined from the ratio of both   concentrations (Metabolic Ratio, MR).  RESULTS:   Almost   half of the patients (46.02%) possessed wild-type haplotype, with 17.05%   of individuals having two fully functional alleles, 57.95% one fully   functional allele and 25% with no fully functional allele. According to   phenotype, most children (96.59%) were classified as fast acetylators,   whereas 1.14% of the cases were intermediate and 2.27% slow acetylators.   There was a positive association between age and MR (R = 0.52985, p   &lt; 0.000001) with a significant MR difference between age categories   (p &lt; 0.001).  CONCLUSIONS:   We found a high proportion   of rapid acetylators compared with other populations. Acetylator   phenotype showed a positive correlation with age, with a significant   change around the 4th year of life.","palabras_clave":"METABOLIC|CLEREANCE|GENOTYPE|PHENOTYPE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38614,"idioma_id":4,"titulo":"Effects of arsenate on tobacco hairy root and seedling growth and its removal","resumen":"        Arsenic  (As) is a highly toxic environmental contaminant to which  most living organisms are exposed. Plants have  evolved several mechanisms to cope with this toxic metalloid;  however, these mechanisms are only partially understood. The  response of plants to As phytotoxicity is highly complex,  with considerable variation among species. In this study,  arsenate (As+5) effects on germination and early root development  of tobacco (Nicotiana tabacum) seedlings were investigated.  Also, As+5 tolerance and removal efficiency of tobacco  hairy roots (HRs) and seedlings were assessed and compared.  Total seed germination capacity was not affected by 10 to  200 &#956;M As+5, while  primary root length and root branching  were reduced by As+5 concentrations that were at or above 100 &#956;M. Both systems were able to  tolerate As+5 concentrations  of 10 &#956;M since no  growth inhibition was detected.  For higher As+5 concentrations, phytotoxicity increased, but it was  mitigated by higher phosphate (Pi) availability. Under the  studied conditions, As+5 removal efficiency of HRs  greatly exceeded that of seedlings. Further, tobacco HRs were  able to accumulate As in their tissues. These results justify  further investigations on As tolerance and detoxification mechanisms  in tobacco, an easy-to-transform crop species with high  biomass, which could allow evaluation of the possible  application of wild type or alternatively transgenic.  ","palabras_clave":"ARSENATE|REMOVAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38615,"idioma_id":4,"titulo":"An image analysis method to quantify CFTR subcellular localization","resumen":"Aberrant protein subcellular localization caused by mutation is a prominent feature of many  human diseases. In Cystic Fibrosis (CF), a recessive lethal disorder that results from dysfunction of the  Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the most common mutation is a  deletion of phenylalanine-508 (pF508del). Such mutation produces a misfolded protein that fails to  reach the cell surface. To date, over 1900 mutations have been identified in CFTR gene, but only a  minority has been analyzed at the protein level. To establish if a particular CFTR variant alters its  subcellular distribution, it is necessary to quantitatively determine protein localization in the  appropriate cellular context. To date, most quantitative studies on CFTR localization have been based  on immunoprecipitation and western blot. In this work, we developed and validated a confocal  microscopy-image analysis method to quantitatively examine CFTR at the apical membrane of  epithelial cells. Polarized MDCK cells transiently transfected with EGFP-CFTR constructs and stained  for an apical marker were used. EGFP-CFTR fluorescence intensity in a region defined by the apical  marker was normalized to EGFP-CFTR whole cell fluorescence intensity, rendering 'apical CFTR ratio'.  We obtained an apical CFTR ratio of 0.67 +\/- 0.05 for wtCFTR and 0.11 +\/- 0.02 for pF508del. In  addition, this image analysis method was able to discriminate intermediate phenotypes: partial rescue  of the pF508del by incubation at 27°C rendered an apical CFTR ratio value of 0.23 +\/- 0.01. We  concluded the method has a good sensitivity and accurately detects milder phenotypes. Improving  axial resolution through deconvolution further increased the sensitivity of the system as rendered an  apical CFTR ratio of 0.76 +\/- 0.03 for wild type and 0.05 +\/- 0.02 for pF508del. The presented  procedure is faster and simpler when compared with other available methods and it is therefore  suitable as a screening method to identify mutations that completely or mildly affect CFTR processing.  Moreover, it could be extended to other studies on the biology underlying protein subcellular  localization in health and disease.","palabras_clave":"CYSTIC FIBROSIS|APICAL|DECONVOLUTION|IMAGE ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38616,"idioma_id":4,"titulo":"Genome sequence of the native apiculate wine yeast Hanseniaspora vineae T02\/19AF","resumen":"The use of novel yeast strains for winemaking improves the quality and provides varietyincluding subtle characteristic differences in fine wines. Here we report the first genome of a yeast strain native to Uruguay, Hanseniaspora vineae T02\/19AF, which has been shown to positively contribute to aroma and wine quality.","palabras_clave":"LEVADURAS|VINO|FERMENTACION|GENOMA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38617,"idioma_id":5,"titulo":"Selección de Condiciones de Cultivo Óptimas para la Secreción de Endoglucanasas por Cepas de Trichoderma Nativas de Misiones","resumen":"Algunas especies de Trichoderma pueden producir grandes cantidades de enzimas hidrolíticas, tales como celulasas, las cuales poseen múltiples aplicaciones industriales y biotecnológicas. El objetivo del presente trabajo fue seleccionar las condiciones de cultivo en medio líquido que favorezcan la secreción de endoglucanasas por cepas del género Trichoderma nativas de la provincia de Misiones. Se llevaron a cabo experimentos utilizando carboximetilcelulosa 0,5% (p\/v) como fuente de carbono y medio Mandels como complejo nitrogenado completo y se ensayaron diferentes condiciones de cultivo utilizando como variables el tiempo de incubación, la forma de inóculo y el sistema de control del pH del medio de cultivo. El presente trabajo permitió establecer que la inoculación en forma de suspensión de esporas y el tamponado del medio con buffer succinato de sodio pH 4,8 representan las condiciones de cultivo en medio líquido más adecuadas para la secreción de endoglucanasas por cepas nativas de T. harzianum y T. koningiopsis.","palabras_clave":"Trichoderma|Condiciones de cultivo|Celulasas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38618,"idioma_id":4,"titulo":"Effect of Co-solvents in the  Enantioselective Esterification of (R\/S)-ibuprofen with Ethanol","resumen":"The commercial biocatalyst Novozym 435 was used for the kinetic resolution of (R\/S)-ibuprofen by esterification with short chain alcohols (ethanol, 1-propanol and 2-propanol) in the absence of organic co-solvent. The best performance enzymatic was obtained by employing ethanol as reagent and solvent. Due to deleterious effect of this alcohol on the integrity of commercial biocatalyst previously reported are used different organic co-solvents (isooctane, n-hexane, carbon tetrachloride, ethyl acetate, acetonitrile and tetrahydrofuran) that allowed reducing the volume of ethanol to be used. Thus, was evaluated the effect of the chemical nature of the co-solvent on enantioselective esterification of (R\/S)-ibuprofen with ethanol. The results show that the best performance was obtained with the reaction system without co-solvent added, importantly for their sustainability and eco-compatibility. Also demonstrated the need to take into account multiple physic-chemical properties of the solvents to analyze their effects on biocatalysis.","palabras_clave":"LIPASES|CO-SOLVENTS|KINETIC RESOLUTION|ESTERIFICATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38619,"idioma_id":4,"titulo":"Magnetite NPs@C with highly-efficient peroxidase-like catalytic activity as an  improved biosensing strategy for selective glucose detection","resumen":"This work reports the novel application of carbon-coated magnetite nanoparticles (mNPs@C) as catalytic nanomaterial included in a composite electrode material (mNPs@C\/CPE) taking advantages of their intrinsic peroxidase-like activity. The nanostructured electrochemical transducer reveals an enhancement of the charge transfer for redox processes involving hydrogen peroxide. Likewise, mNPs@C\/CPE demonstrated to be highly selective even at elevated concentrations of ascorbic acid and uric acid, the usual interferents of blood glucose analysis. Upon these remarkable results, the composite matrix was further modified by the addition of glucose oxidase as biocatalyst, in order to obtain a biosensing strategy (GOx\/mNPs@C\/CPE) with enhanced properties for the electrochemical detection of glucose. GOx\/mNPs@C\/CPE exhibit a linear range up to 7.5×10&#8722;3&#8197;mol&#8201;L&#8722;1 glucose, comprising the entirely physiological range and incipient pathological values. The average sensitivity obtained at &#8722;0.100&#8197;V was (1.62±0.05)×105&#8197;nA&#8201;L&#8201;mol&#8722;1 (R2=0.9992), the detection limit was 2.0×10&#8722;6&#8197;M while the quantification limit was 6.1×10&#8722;6&#8197;mol&#8201;L&#8722;1. The nanostructured biosensor demonstrated to have an excellent performance for glucose detection in human blood serum even for pathological values.","palabras_clave":"Carbon-coated magnetite nanoparticles|Electrochemical glucose biosensor|Glucose oxidase|Modified-carbon paste electrode|Peroxidase-like activity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38620,"idioma_id":4,"titulo":"Crystallization in PHB\/DGEBA blends","resumen":"Real-time experiments using small-angle X-ray scattering and differential scanning calorimetry on blends of the semicrystalline polyester poly(3-hydroxybutyrate) (PHB) and amorphous monomer epoxy DGEBA (diglycidyl ether of bisphenol A) were performed. Differences in the processes of melting and recrystallization were observed in blends relative to pure PHB. The results obtained in this study indicated that re-crystallization is more important in blends with 50% DGEBA than in pure PHB. Moreover, segregation toward the interfibrillar region would facilitate re-crystallization.","palabras_clave":"BLENDS|CRISTALLIZATION|SAXS|POLY(3-HYDROXYBUTYRATE)|SEGREGATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38621,"idioma_id":4,"titulo":"The IBMAP approach for Markov network structure learning","resumen":"In this work we consider the problem of learning the structure of Markov networks from data. We present an approach for tackling this problem called IBMAP, together with an efficient instantiation of the approach: the IBMAP-HC algorithm, designed for avoiding important limitations of existing independence-based algorithms. These algorithms proceed by performing statistical independence tests on data, trusting completely the outcome of each test. In practice tests may be incorrect, resulting in potential cascading errors and the consequent reduction in the quality of the structures learned. IBMAP contemplates this uncertainty in the outcome of the tests through a probabilistic maximum-a-posteriori approach. The approach is instantiated in the IBMAP-HC algorithm, a structure selection strategy that performs a polynomial heuristic local search in the space of possible structures. We present an extensive empirical evaluation on synthetic and real data, showing that our algorithm outperforms significantly the current independence-based algorithms, in terms of data efficiency and quality of learned structures, with equivalent computational complexities. We also show the performance of IBMAP-HC in a real-world application of knowledge discovery: EDAs, which are evolutionary algorithms that use structure learning on each generation for modeling the distribution of populations. The experiments show that when IBMAP-HC is used to learn the structure, EDAs improve the convergence to the optimum.","palabras_clave":"MARKOV NETWORK|STRUCTURE LEARNING|INDEPENDENCE TESTS|KNOWLEDGE DISCOVERY|EDAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38622,"idioma_id":4,"titulo":"A sulfated galactan from the mucilaginous sheath of the red filamentous alga Chroodactylon ornatum (Stylonematophyceae, Rhodophyta)","resumen":"The pseudofilamentous red alga Chroodactylon ornatum was grown in f\/2 culture medium with the addition of 10, 34, and 100 &#956;M (nominal concentration) cupric sulfate. The bioassays were terminated at two selected end points (days 4 and 12). Growth inhibition, changes in pigment composition, and oxidative stress indicators such as phenolic compounds and lipid peroxidation (dosed as thiobarbituric reactive substances) were observed in cultures with 34 and 100-&#956;M cupric sulfate.  Quinacrine (Atebrin) and chlorotetracycline fluorochromes showed abundant vacuoles of acidic content, related with mucilage secretion. Structural analyses by methylation, desulfation-methylation, alkaline treatment, and NMR spectroscopy revealed that the mucilaginous sheath of C. ornatum contains a sulfated galactan with a backbone of alternating 3-linked beta-D-galactopyranose and 4-linked alpha-L-galactopyranose moieties, i.e., an agaran. The absence of 3,6-anhydrogalactose and of its precursor unit (alpha-galactose 6-sulfate) were confirmed. The highly sulfated polysaccharide contained these ester groups on the C-2 and C-4 hydroxyl groups of the 3-linked unit and on C-3 of the 4-linked units. The large proportion of sulfate esterification in this polysaccharide can be related to the extracellular biosorption of copper divalent cation (2.5±0.4 mg per gram of dry weight) and to copper tolerance in bioassays.","palabras_clave":"Chroodactylon ornatum|Mucilage|Sulfated galactan|Copper bioassays"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38623,"idioma_id":4,"titulo":"Biodistribution of the boron carriers boronophenylalanine (BPA) and\/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases","resumen":"BNCT was proposed for the treatment of diffuse,non-resectable tumors in the lung.We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPAand\/orGB-10 in an experimental model of disseminated lung metastases in rats.All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung.Absolute tumor boron concentration values were therapeutically useful(25?76ppm)for 3 protocols.Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.","palabras_clave":"biodistribution|BPA|GB-10|BNCT|lung metastases"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38624,"idioma_id":4,"titulo":"Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA","resumen":"Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70?85 ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSHþBPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.","palabras_clave":"oral cancer|BNCT|hamster cheek pouch |BSH|precancerous tissue"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38625,"idioma_id":4,"titulo":"Therapeutic Efficacy of Boron Neutron Capture Therapy Mediated by Boron Rich Liposomes for Oral Cancer in the Hamster Cheek Pouch Model","resumen":"The application of boron neutron capture therapy (BNCT) mediated by liposomes containing 10Benriched polyhedral borane and carborane derivatives for the treatment of head and neck cancer in the hamster cheek pouch oral cancer model is presented. These liposomes are composed of an equimolar ratio of cholesterol and 1,2-distearoyl-sn-glycero-3-phosphocholine, incorporating K[nido-7-CH3(CH2)15-7,8-C2B9H11] (MAC) in the bilayer membrane while encapsulating the hydrophilic species Na3[ae-B20H17NH3] (TAC) in the aqueous core. Unilamellar liposomes with a mean diameter of 83 nm were administered intravenously in hamsters. After 48h, the boron concentration in tumorswas 67±16 ppm while the precancerous tissue contained 11±6 ppm, and the tumor\/normal pouch tissue boron concentration ratio was 10:1. Neutron irradiation giving a 5 Gy dose to precancerous tissue (corresponding to 21 Gy in tumor) resulted in an overall tumor response of 70% after 4 weeks post-treatment period. In contrast, the beam-only protocol gave an overall tumor response of only 28%. Once repeated BNCT treatment with readministration of liposomes at an interval of 4, 6 or 8 weeks resulted in the overall tumor response of 70-88%, out of which the complete response ranged from 37 to 52%. Due to good therapeutic outcome, it was possible to extend the follow-up of BNCT treatment groups to 16 weeks after the first treatment. No radiotoxicity to normal tissue was observed. A salient advantage of these liposomes was that only mild mucositis in dose-limiting precancerous tissue was associated with a sustained tumor response of 70-88%.","palabras_clave":"ONCOLOGY|NEUTRON RADIATION|CANCER|BORONATED LIPOSOMES|BNCT|HAMSTER CHEEK POUCH ORAL CANCER MODEL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38626,"idioma_id":4,"titulo":"Critical Nitrogen Concentration Declines with Soil Water Availability in Tall Fescue","resumen":"The diagnosis of the N status of crops is based on the concept of critical N concentration (Ncr), which is the minimum N concentration in shoot biomass (SB) required for maximizing growth. A reference curve of Ncr decrease (Ref-Ncr) with SB increase proposed for C3 species (Ref-Ncr=48 SB-0.32) was validated for several crops growing without water deficiency in different sites and seasons; however, the validity of Ref-Ncr is uncertain when water is limiting. The objective was to assess whether water stress affects Ncr. Five regrowths of a temperate-type tall fescue [Lolium arundinaceum (Schreb.) Darbysh.] were followed during autumn, spring, and summer in Balcarce, Argentina. Several N rates were applied and SB accumulation and N concentration were measured in each of four to six sequential SB harvests performed at every regrowth. SB, Ncr, available soil water, reference evapotranspiration (ET0), and real evapotranspiration (RET) were estimated. Ncr agreed well with Ref-Ncr when soil water was nonlimiting, but it was consistently lower than Ref-Ncr whenever crop RET was reduced (RET\/ET0<1). Indeed, crop average Ncr during an entire regrowth scaled linearly with the average level of water stress in the period: (Ncr\/Ref-Ncr)avg = 0.83 (RET\/ET0)avg + 0.22 (R2 = 0.90, p < 0.0001). Hence, while Ref-Ncr remains appropriate for assessing crop N status under adequate water availability conditions, the N nutrition management of water stressed crops should be guided by their actualNcr.","palabras_clave":"N concentration of reference|water stress|NNI|diagnosis|fertilization|crop growth modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38627,"idioma_id":4,"titulo":"The allocation of assimilated carbon to shoot growth: in situ assessment in natural grasslands reveals nitrogen effects and interspecific differences","resumen":"In grasslands, sustained nitrogen loading would increase the proportion of assimilated carbon allocated to shoot growth (A shoot), because it would decrease allocation to roots and also encourage the contribution of species with inherently high A shoot. However, in situ measurements of carbon allocation are scarce. Therefore, it is unclear to what extent species that coexist in grasslands actually differ in their allocation strategy or in their response to nitrogen. We used a mobile facility to perform steady-state 13C-labeling of field stands to quantify, in winter and autumn, the daily relative photosynthesis rate (RPR~tracer assimilated over one light-period) and A shoot (~tracer remaining in shoots after a 100 degree days chase period) in four individual species with contrasting morpho-physiological characteristics coexisting in a temperate grassland of Argentina, either fertilized or not with nitrogen, and either cut intermittently or grazed continuously. Plasticity in response to nitrogen was substantial in most species, as indicated by positive correlations between A shoot and shoot nitrogen concentration. There was a notable interspecific difference: productive species with higher RPR, enhanced by fertilization and characterized by faster leaf turnover rate, allocated ~20 % less of the assimilated carbon to shoot growth than species of lower productivity (and quality) characterized by longer leaf life spans and phyllochrons. These results imply that, opposite to the expected response, sustained nitrogen loading would change little the A shoot of grassland communities if increases at the species-level are offset by decreases associated with replacement of ?low RPR-high A shoot? species by ?high RPR-low A shoot? species.","palabras_clave":"Carbon partitioning|Carbon storage|Structural tissue|Nitrogen loading|Carbon use efficiency"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38628,"idioma_id":5,"titulo":"LONGITUD DE LA VAINA COMO DETERMINANTE DE LA CALIDAD DE HOJAS DE Festuca arundinacea DURANTE UN PERÍODO DE REBROTE","resumen":"Se evaluó la calidad nutritiva de las láminas de  rebrotes de Festuca arundinacea  provenientes de dos tratamientos de corte de distinta altura de remanentes (40 mm y 100 mm). El experimento se  realizó en 500 macetas al aire libre sin limitantes hídricas ni de N y P, en un diseño completamente aleatorizado (n=3) en la primavera-verano 2011-2012. Se midió la tasa de elongación foliar (TEF), intervalo de aparición de hoja (IAH),  vida media foliar (VMF), número de hojas vivas (NHV) y largo de lámina y vaina  en 15 macollos marcados por tratamiento. Paralelamente, se realizaron tres cosechas destructivas de 6 macetas\/tratamiento\/repetición, cuando la pastura tenía 2, 3 y 4 hojas acumuladas por macollo (2H, 3H  y 4H, respectivamente). En las láminas se determinó el contenido de fibra detergente neutro (FDN), la digestibilidad  de la FDN (DFDN)  y la digestibilidad aparente de la materia seca (DAMS) a 24 h de incubación in  vitro (digestor DaisyII, ANKOM). Las variables de morfogénesis se analizaron como  medidas repetidas en el tiempo, y las de calidad ajustando funciones de  regresión con la edad y largo foliar. Las comparaciones se realizaron mediante  análisis de variables Dummy y ANVA (Tukey). La temperatura media diaria del  rebrote fue de 19,7±3°C. La altura del remanente afectó la morfogénesis, estructura foliar y la  calidad de las láminas del rebrote. El remanente más bajo produjo un rebrote  con vainas más cortas (65 vs 130   mm), láminas de menor longitud (444 vs 629 mm), de menor TEF (16 vs 25 mm.día-1) e IAH  (275 vs 354°Cd), sin diferenciarse en VMF (629±34 GDC). También tuvo más hojas  vivas por macollo (2,5 vs 2,0 hojas vivas.macollo-1) y láminas de  mayor calidad. Estas tuvieron un aumento del 16% en la DFDN, de 9% en la DAMS y similar FDN (62,3±0,6%).  Se concluye que los cambios ocasionados por la reducción del tubo de vainas en  la morfogénesis, estructura foliar y en la digestibilidad de la fibra favorecen  la calidad del rebrote. ","palabras_clave":"REMANENTE|VMF|DFDN|LARGO FOLIAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38629,"idioma_id":4,"titulo":"Live-shearing effects on population parameters and movements in sedentary and migratory populations of guanacos","resumen":"Live capture and shearing of wild guanacos may affect their reproductive success and population resilience, so it is important to evaluate these impacts to assess the biological sustainability of fiber production. We evaluated the use effects on survival and reproduction, population density and structure, daily movements, ranging behaviour and spatial distribution in a sedentary and a migratory population. We assessed these population variables using radiotelemetry and line-transect surveys before and after capture. We estimated high post-shearing survival rates in both populations and yearling production was similar in sheared and non-sheared females. We did not find significant variations in density and population structure before and after management in the sedentary population, while density declined and population structure changed significantly after assembly of the capture structure in the migratory population. Average distance moved by radiocollared guanacos during the first two days after shearing was 3 times longer than the average daily distance moved during the following 30 days, with high variability in daily movements among individuals. Average home-range size of shorn guanacos was 25 to 35% smaller during the two months immediately after shearing than during the same period the following year. In the sedentary population the handling modifies the spatial distribution pattern. Conversely, we did not observe significant differences in the spatial distribution pattern in the migratory population. Management of wild guanaco, if closely monitored, may contribute to develop a productive activity that complements livestock production, increasing tolerance towards guanacos and promoting conservation of wildlife and habitats.","palabras_clave":"Arid ecosystem|biodiversity conservation|Lama guanicoe|management effec"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38630,"idioma_id":4,"titulo":"Clinical signs suggestive of mange infestation in a free-ranging maned wolf (Chrysocyon brachyurus) in the Moxos savannahs of Beni, Bolivia","resumen":"Sarcoptic mange is usually endemic in wild canid populations. Several other infectious and parasitic disease agents have been reported for free-ranging maned wolves (Chrysocyon brachyurus). This field report documents the sighting of a free-ranging maned wolf in the Beni department of Bolivia with clinical signs sug- gestive of sarcoptic mange-like infestation. The constant threat of transmission of mange from domestic dogs as well as other species of wild canids could have detrimental effects on the population.","palabras_clave":"Bolivia|Canidae|mane wolf|Moxos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38631,"idioma_id":5,"titulo":"Google Earth + Sistemas de Información Geográfica. Proyecto y práctica geoinformática en la escuela media","resumen":"El presente trabajo desarrolla la línea de investigación orientada a la aplicación de tecnologías geoinformáticas como transferencia del ámbito universitario a la enseñanza media formuladas en el GESIG desde el año 2011. El proyecto tiene como título Aplicación de Sistemas de Información Geográfica (SIG) para la educación en Tecnologías de la Información y la Comunicación (TIC) en la escuela secundaria. Aportes de la Geografía para el apoyo al desarrollo de la perspectiva espacial a través del modelado cartográfico digital y se ha desarrollado en una serie de etapas: 1° 2011 (concluida): Producción de material didáctico. 2° 2012-2013 (concluida): Implementación en asignaturas universitarias. 3° 2014 (en formulación): Implementación en la enseñanza media. En las páginas siguientes se detallarán las acciones realizadas en el GESIG y la participación de sus integrantes. Se detallarán los objetivos y resultados obtenidos en cada etapa y la formulación de las tareas para el año 2014 tendientes a su finalización. Asimismo se incluyen los dos trabajos prácticos que presentan técnicamente la relación entre Google Earth y Sistemas de Información Geográfica como modelo a ser aplicado en el área de estudio de la escuela de enseñanza media en donde se implementará la última etapa el proyecto. ","palabras_clave":"Google Earth|Sistemas de Información Geográfica|Educación Geográfica|Geoinformática"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38632,"idioma_id":4,"titulo":"Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP","resumen":"The development of selective agents capable of discriminating between protein kinase C (PKC) isoforms and other diacylglycerol (DAG)-responsive C1 domain-containing proteins represents an important challenge. Recent studies have highlighted the role that Ras guanine nucleotide-releasing protein (RasGRP) isoforms play both in immune responses as well as in the development of prostate cancer and melanoma, suggesting that the discovery of selective ligands could have potential therapeutic value. Thus far, the N-methyl-substituted indololactone 1 is the agonist with the highest reported potency and selectivity for RasGRP relative to PKC. Here we present the synthesis, binding studies, cellular assays and biophysical analysis of interactions with model membranes of a family of regioisomers of 1 (compounds 2?5) that differ in the position of the linkage between the indole ring and the lactone moiety. These structural variations were studied to explore the interaction of the active complex (C1 domain-ligand) with cellular membranes, which is believed to be an important factor for selectivity in the activation of DAG-responsive C1 domain containing signaling proteins. All compounds were potent and selective activators of RasGRP when compared to PKCá with selectivities ranging from 6 to 65 fold. However, the parent compound 1 was appreciably more selective than any of the other isomers. In intact cells, modest differences in the patterns of translocation of the C1 domain targets were observed. Biophysical studies using giant vesicles as model membranes did show substantial differences in terms of molecular interactions impacting lipid organization, dynamics and membrane insertion. However, these differences did not yield correspondingly large changes in patterns of biological response, at least for the parameters examined.","palabras_clave":"Indolo-lactones|C1 domain|RasGRP|Cancer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38633,"idioma_id":4,"titulo":"A Sunflower Lectin with Antifungal Properties and Putative Medical Mycology Applications","resumen":"Lectins are carbohydrate-binding proteins with a high specificity for a variety of glycoconjugate sugar motifs. The jacalin-related lectins (JRLs) are considered to be a small sub-family composed of galactose- and mannose-specific members. Using a proteomics approach, we have detected a 16 kDa protein (Helja) in sunflower seedlings that was further purified by mannose-agarose affinity chromatography. The aim of this work was to characterize the biological activity of Helja and to explore potential applications for the antifungal activity of this plant lectin against medically important yeasts. To initially assess the agglutination properties of the lectin, Saccharomyces cerevisiae cells were incubated with increasing concentrations of the purified lectin. At a concentration of 120 µg\/ml, Helja clearly agglutinated these cells. The ability of different sugars to inhibit S. cerevisiae cell agglutination determined its carbohydrate-specificity. Among the monosaccharides tested, D-mannose had the greatest inhibitory effect, with a minimal concentration of 1.5 mM required to prevent cell agglutination. The antifungal activity was evaluated using pathogenic fungi belonging to the Candida and Pichia genera. We demonstrate that 200 µg\/ml of Helja inhibited the growth of all yeasts, and it induced morphological changes, particularly through pseudohyphae formation on Candida tropicalis. Helja alters the membrane permeability of the tested fungi and is also able to induce the production of reactive oxygen species in C. tropicalis cells. We concluded that Helja is a mannose-binding JRL with cell agglutination capabilities and antifungal activity against yeasts. The biological properties of Helja may have practical applications in the control of human pathogens. ","palabras_clave":"LECTIN|PROTEIN CHEMISTRY|MOLECULAR MICROBIAL BIOCHEMISTRY|BIOTECHNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38634,"idioma_id":4,"titulo":"Creation of the Argentina-Alzheimer's disease neuroimaging initiative","resumen":"The Alzheimer´s Disease Neuroimaging Initiative (ADNI) is a multisite, longitudinal study that assesses clinical, imaging, genetic, and biospecimen biomarkers through the process of normal aging to mild cognitive impairment and dementia. We present the creation of the Argentina-ADNI - the first South American ADNI - and its effort to acquire data comparable with those gathered in other worldwide ADNI centers.","palabras_clave":"Alzheimer disease|imaging|genetics|biomarkers"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38635,"idioma_id":4,"titulo":"Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia","resumen":"Measures of social competence are closely related to actual community functioning in patients with schizophrenia. However, the neurobiological mechanisms underlying competence in schizophrenia are not fully understood. We hypothesized that social deficits in schizophrenia are explained, at least in part, by abnormally lateralized patterns of brain activation in response to tasks engaging social cognition, as compared to healthy individuals. We predicted such patterns would be partly heritable, and therefore affected in patients´ nonpsychotic siblings as well. We used a functional magnetic resonance image paradigm to characterize brain activation induced by theory of mind tasks, and two tests of social competence, the Test of Adaptive Behavior in Schizophrenia (TABS), and the Social Skills Performance Assessment (SSPA) in siblings discordant for schizophrenia and comparable healthy controls (n  14 per group). Healthy individuals showed the strongest correlation between social competence and activation of right hemisphere structures involved in social cognitive processing, whereas in patients, the corre- lation pattern was lateralized to left hemisphere areas. Unaffected siblings of patients exhibited a pattern intermediate between the other groups. These results support the hypothesis that schizophrenia may be characterized by an abnormal functioning of nondominant hemisphere structures involved in the pro- cessing of socially salient information.","palabras_clave":"schizophrenia|siblings|social functioning|cognition"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38636,"idioma_id":4,"titulo":"Strong differences in the CH4 emission from feces of grazing steers submitted to different feeding schedules","resumen":"When studying the effects of changing the feeding schedule of Holstein steers grazing in a pure oat field, it was observed that the fecal matter of animals grazing in the morning emitted much more methane than that of steers grazing in the afternoon. Feces from two groups of 10 steers with different feeding schedules were collected on the same day and separately mixed to form two composite samples. Then, five sub-samples of each composite sample were randomly placed on the oat field and CH4 emissions were measured after deposition for 27 days. The difference in the emissions was in qualitative agreement with the pronounced loss of organic matter from the morning samples during the experimental period.","palabras_clave":"FECAL MATTER|METHANE EMISSION|OAT PASTURE|GRAZING STEERS|GRAZING SCHEDULES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38637,"idioma_id":4,"titulo":"Invertible bimodule categories over the representation category  of a Hopf algebra","resumen":"For any finite-dimensional Hopf algebra H we construct a group homomorphism $iga(H)\to \text{BrPic}(Rep(H))$, from the group of equivalence classes of $H$-biGalois objects to the group of equivalence classes of invertible exact $Rep(H)$-bimodule categories. We discuss the injectivity of this map. We exemplify in the case $H=T_q$ is a Taft Hopf algebra and for this we classify all exact indecomposable $Rep(T_q)$-bimodule categories.","palabras_clave":"Categoría tensorial|Álgebra de Hopf"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38638,"idioma_id":4,"titulo":"Testes Mass, but Not Sperm Length, Increases with Higher Levels of Polyandry in an Ancient Sex Model","resumen":"There is strong evidence that polyandrous taxa have evolved relatively larger testes than monogamous relatives. Sperm size may either increase or decrease across species with the risk or intensity of sperm competition. Scorpions represent an ancient direct mode with spermatophore-mediated sperm transfer and are particularly well suited for studies in sperm competition. This work aims to analyze for the first time the variables affecting testes mass, ejaculate volume and sperm length, according with their levels of polyandry, in species belonging to the Neotropical family Bothriuridae. Variables influencing testes mass and sperm length were obtained by model selection analysis using corrected Akaike Information Criterion. Testes mass varied greatly among the seven species analyzed, ranging from 1.661.1 mg in Timogenes dorbignyi to 16.364.5 mg in Brachistosternus pentheri with an average of 8.465.0 mg in all the species. The relationship between testes mass and body mass was not significant. Body allocation in testes mass, taken as Gonadosomatic Index, was high in Bothriurus cordubensis and Brachistosternus ferrugineus and low in Timogenes species. The best-fitting model for testes mass considered only polyandry as predictor with a positive influence. Model selection showed that body mass influenced sperm length negatively but after correcting for body mass, none of the variables analyzed explained sperm length. Both body mass and testes mass influenced spermatophore volume positively. There was a strong phylogenetic effect on the model containing testes mass. As predicted by the sperm competition theory and according to what happens in other arthropods, testes mass increased in species with higher levels of sperm competition, and influenced positively spermatophore volume, but data was not conclusive for sperm length.","palabras_clave":"SPERM COMPETITION|MATING SYSTEM|SCORPIONES|TESTES MASS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38639,"idioma_id":4,"titulo":"Harmonics Measurement With a Modulated Sliding Discrete Fourier Transform Algorithm","resumen":"Accurate harmonics estimation has become a key issue in power quality assessment. This paper deals with a discrete Fourier transform (DFT)-based measurement technique,which can be easily employed to accurately determine theharmonic components of a distorted signal, i.e., voltage or  current. The proposed method is based on a modulated sliding DFT algorithm, which is unconditionally stable and does not accumulate errors due to finite precision representation, and a variable sampling period technique (VSPT) to achieve a frequency adaptive mechanism. It is worth noting that the VSPT changes the sampling period for a variable grid frequency condition, leading to a constant sampling frequency under steady-state conditions. The proposed method provides: 1) high degree of  accuracy; 2) structural\/performance robustness; and 3) frequency  adaptability. Given the modular nature of the method, it is implemented on a field programmable gate array. Simulations and experimental tests are shown to verify the performance of the proposed method.","palabras_clave":"DFT|FPGA|harmonics measurement|power quality|signal processing|variable sampling period"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38640,"idioma_id":4,"titulo":"Repetitive Control With Adaptive Sampling Frequency for Wind Power Generation Systems","resumen":"This paper presents a novel repetitive control (RC) for wind power generation systems (WPGS), which achieves optimal performance in steady-state conditions due to a variable sampling\/switching period technique (VSPT). The main objective of VSPT is to obtain an integer number of samples per grid period, which solves the main problem of RC, i.e., the loss of rejection to periodic disturbances due to grid frequency drift. The sampling\/switching frequency is adjusted with a variable sampling period filter phase-locked loop, which also adds robustness to the system due to its inherent tolerance to grid voltage distortion and unbalances, and events such as frequency steps and faults. The control and synchronism subsystems are described, designed, and verified experimentally in a 10-kW WPGS. The results obtained prove the accuracy of the proposed control even under severe disturbances, typical in grids with high WPGS penetration, providing ancillary functions to enhance reliability and reduce operational costs.","palabras_clave":"Grid-tie current-controlled three-phase inverters|power quality|repetitive control|wind energy|wind power generation systems"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38641,"idioma_id":4,"titulo":"ELECTROCHEMICAL CHARACTERIZATION OF CHROMATE FREE CONVERSION COATINGS ON ELECTROGALVANIZED STEEL","resumen":"The  chromate conversion treatment is widely used, but it requires highly toxic  chromic acid solutions with the consequent effluent disposal and ecological  problems. The removal of these toxic chemicals is considered a priority within  European Union. The corrosion resistance of three alternative treatments  applied on electrogalvanised steel, and immersed in aerated 0.3 M Na2SO4 solution,  pH 10, at 25 °C, was investigated using electrochemical techniques. Their  performance was compared with the obtained using the traditional Cr6+-based treatment in the same conditions. The achieved  results show that the alternative coatings exhibited discrete protective  properties in the sulphate solution. The nitro-cobalt chemical conversion  treatment showed similar protective properties than the traditional Cr6+-based treatment, while with the Cr3+-based treatment those were very poor. The phosphate treatment  initially performed acceptably but as the time elapsed, its protective  properties decreased.","palabras_clave":"conversion coatings|electrodeposition|electrochemical techniques|corrosion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38642,"idioma_id":5,"titulo":"HERRAMIENTAS INFORMÁTICAS: USO EN PROCESOS DE ENSEÑANZA-APRENDIZAJE DE ENTORNOS VIRTUALES","resumen":"En el presente estudio se propuso indagar sobre las herramientas  virtuales que permiten aplicar estrategias didácticas con miras a facilitar un aprendizaje significativo dentro de la plataforma virtual. A su vez se identifican las estrategias utilizadas por los docentes de una universidad de Argentina en el campus virtual. La intención del estudio fue identificar si se dan patrones de uso de las herramientas virtuales o de estrategias didácticas relacionadas con diferentes variables, tales como el ámbito disciplinario o la capacitación recibida. La finalidad fue explorar las herramientas que asisten apropiadamente a las estrategias implementadas por los docentes. Se pretende proyectar a una cantidad significativa de docentes de la institución hacia las desafiantes tendencias que proponen las tecnologías informáticas virtuales.","palabras_clave":"Educación|Plataforma virtual|Técnicas de aprendizaje|Herramientas de aprendizaje"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38643,"idioma_id":5,"titulo":"La  colección de preparados palinologicos de la  cátedra  de Palinologia de la Facultad de Ciencias Naturales y Museo (FCNyM), Universidad Nacional de La Plata (UNLP), Buenos Aires, Argentina.","resumen":"Se da a conocer la colección de preparados palinológicos de la Cátedra de Palinología, de la Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata. Se menciona la historia de la colección, material tipo y proyectos de investigación que se desarrollan actualmente en la cátedra.&nbsp;","palabras_clave":"Palinoteca|Colecciones|Universidad Nacional de La Plata|Museo de La Plata"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38644,"idioma_id":4,"titulo":"The successive projections algorithm for interval selection in trilinear partial least-squares with residual bilinearization","resumen":"In this work the Successive Projection Algorithm is presented for intervals selection in N-PLS for three-way  data modeling. The proposed algorithm combines noise-reduction properties of PLS with the possibility  of discarding uninformative variables in SPA. In addition, second-order advantage can be achieved by the  residual bilinearization (RBL) procedure when an unexpected constituent is present in a test sample. For  this purpose, SPA was modified in order to select intervals for use in trilinear PLS. The ability of the proposed  algorithm, namely iSPA-N-PLS, was evaluated on one simulated and two experimental data sets,  comparing the results to those obtained by N-PLS. In the simulated system, two analytes were quantitated  in two test sets, with and without unexpected constituent. In the first experimental system, the determination  of the four fluorophores (l-phenylalanine; l-3,4-dihydroxyphenylalanine; 1,4-dihydroxybenzene  and l-tryptophan) was conducted with excitation-emission data matrices. In the second experimental  system, quantitation of ofloxacin was performed in water samples containing two other uncalibrated  quinolones (ciprofloxacin and danofloxacin) by high performance liquid chromatography with UV?vis  diode array detector. For comparison purpose, a GA algorithm coupled with N-PLS\/RBL was also used in  this work. In most of the studied cases iSPA-N-PLS proved to be a promising tool for selection of variables  in second-order calibration, generating models with smaller RMSEP, when compared to both the global  model using all of the sensors in two dimensions and GA-NPLS\/RBL","palabras_clave":"MULTIWAY DATA|VARIABLE SELECTION|SECOND ORDER CALIBRATION|SECON ORDER ADVANTAGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38645,"idioma_id":4,"titulo":"Towards bond selective chemistry from first principles: Methane on metal surfaces","resumen":"Controlling bond-selective chemical reactivity is of great importance and has a broad range of applications. Here, we present a molecular dynamics study of bond selective reactivity of methane and its deuterated isotopologues (i.e. CH_{4&#8722;x}D_x, x=0,1,2,3,4) on Ni(111) and Pt(111) from first principles calculations. Our simulations allow for reproducing the full C-H bond selectivity recently achieved experimentally via mode-specific vibrational excitation and explain its origin. Moreover,  we also predict the hitherto unexplored influence of the molecular translational energy on such a selectivity as well as the conditions under which the full selectivity can be realized for the a priori  less active C-D bond.","palabras_clave":"Methane|Adsorption|DFT|Forcefields"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38646,"idioma_id":4,"titulo":"Study of the potential value of Ilex affinis (Aquifoliaceae) as a novel source for the food and pharmaceutical  industries?","resumen":"Ilex paraguariensis St. Hilaire (Aquifoliaceae) is processed industrially to produce the commercial product ?yerba mate? which is used as a tea-like beverage. It is one of the most commercialized plants of South America. It is exported to the US, Europe and Asia as vegetal drug or extracts used in complementary and alternative medicine and in formulations for functional foods due to its properties as a CNS stimulant, diuretic, weight reducing, antioxidant and antihypercholesterolemic, among others. Ilex affinis grows in the same habitat and is used as substitute or adulterant of I. paraguariensis. This species was never investigated before. The objective of this work was to assess the phytochemical composition and to determine the pharmacological activity, according with the major compounds present in it. The results showed small quantities of caffeine and theobromine, but a considerable amount of polyphenols, especially chlorogenic acid and isochlorogenic acid. I. affinis extracts presented scavenging activity on free radical DPPH in a concentration-dependent manner. Antiproliferative action on lymphoma cell line exerting both cytostatic and cytotoxic activities was also demonstrated.","palabras_clave":"Ilex affinis|Antioxidant |antiproliferative|Phytochemistry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38647,"idioma_id":4,"titulo":"Metallothionein 1G and Zinc Sensitize Human Colorectal Cancer Cells to Chemotherapy","resumen":"Metallothioneins (MT) are a family of low molecular weight proteins that are silenced during colorectal cancer progression, mainly through epigenetic mechanisms, and this loss is associated with poor survival. In this article, we show that overexpression of the MT1G isoform sensitizes colorectal cell lines to the chemotherapeutic agents oxaliplatin (OXA) and 5-fluorouracil (5-FU), in part through enhancing p53 and repressing NF-&#954;B activity. Despite being silenced, MTs can be reinduced by histone deacetylase inhibitors such as trichostatin A and sodium butyrate. In fact, this induction contributes to the cytotoxicity of these agents, given that silencing of MTs by siRNAs reduces their growth-inhibitory activities. Zinc ions also potently enhance MT expression and are cytotoxic to cancer cells. We show for the first time that OXA and 5-FU induce higher levels of intracellular labile zinc, as measured using the fluorescent probe FLUOZIN-3, and that such zinc contributes to the activation of p53 and repression of NF-&#954;B. Addition of zinc enhanced growth inhibition by OXA and 5-FU, and was also capable of resensitizing 5-FU-resistant cell lines to levels comparable with sensitive cell lines. This effect was MT independent because silencing MTs did not affect zinc cytotoxicity. In conclusion, we show that MT induction and zinc administration are novel strategies to sensitize colorectal cancer cells to presently utilized chemotherapeutic agents.","palabras_clave":"metallothioneins|zinc|colorectal cancer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38648,"idioma_id":5,"titulo":"La diversidad floral del borde afecta la riqueza y abundancia de  visitantes florales nativos en cultivos de girasol","resumen":"La declinación en la diversidad y abundancia de polinizadores relacionada a diversos tipos de  disturbios de origen antrópico es un tema de debate en el contexto del cambio en el uso de la tierra. Dentro  de este debate se ha enfatizado la importancia de los remanentes de hábitats naturales y semi-naturales  como reservorios de polinizadores para cultivos dependientes de ellos. El sudeste de la Provincia de Buenos  Aires constituye una zona agrícolo-ganadera con un alto grado de uso y alteración de la tierra. Sin embargo,  los márgenes de cultivos asociados a los bordes de caminos pueden proveer recursos florísticos y sitios de  nidificación para una gran diversidad de polinizadores, los que podrían, eventualmente, incrementar la  polinización y la productividad de muchos cultivos aledaños dependientes de ellos. Aquí evaluamos el  efecto de la diversidad floral de los bordes de cultivos sobre la riqueza y abundancia de los visitantes florales  en 17 lotes de girasol en la zona de Balcarce y Lobería. Nuestros resultados indican que la diversidad floral  del borde tuvo un efecto positivo sobre la riqueza y abundancia de visitantes florales nativos en el cultivo  adyacente. En consecuencia, los servicios de polinización en estos agroecosistemas podrían ser promovidos  por un incremento en la cantidad y diversidad de estos hábitats marginales.","palabras_clave":"VISITANTES FLORALES|DIVERSIDAD|AGROECOSISTEMAS|GIRASOL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38649,"idioma_id":4,"titulo":"Differential and total cross sections of non-capture breakup reactions in the  6Li+ 144Sm system","resumen":"The breakup of the projectile-like fragments in reactions induced by 6Li beams on a 144Sm target at energies close to the Coulomb barrier has been measured through the coincident detection of the emitted light particles. The emphasis of the measurements and the data analysis were placed in the complete  characterization of the alpha-deuteron breakup mode by means of the identification of the breakup fragments and the determination of the total Q value, relative energy of the breakup products, and the angular distribution of their emission. Within the ranges of these variables covered by the present measurements, the results for the 6Li -> d+alpha mode show a clear dominance of the resonant channel through the 3+ state at 2.186 MeV over other resonant and nonresonant channels. Differential cross sections as a function of the center-of-mass angles of the intermediate binary collision and of the breakup emission, as well as integrated cross sections as a function of energy, have been obtained. The data are compared with those measured for competing processes in the same system and with the results of calculations based on a dynamic classical model that describes noncapture breakup, incomplete fusion, and complete fusion.","palabras_clave":"6LI+144SM|BREAKUP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38650,"idioma_id":4,"titulo":"Experimental study of linear and non linear regimes of density driven instabilities induced by CO2 dissolution in water","resumen":"Density driven instabilities produced by CO2 (gas) dissolution in water containing a color indicatorwere studied in a Hele Shaw cell. The images were analyzed and instability patterns werecharacterized by mixing zone temporal evolution, dispersion curves, and the growth rate for differentCO2 pressures and different color indicator concentrations. The results obtained from an exhaustiveanalysis of experimental data show that this system has a different behaviour in the linear regime ofthe instabilities (when the growth rate has a linear dependence with time), from the nonlinear regimeat longer times. At short times using a color indicator to see the evolution of the pattern, the imagesshow that the effects of both the color indicator and CO2 pressure are of the same order ofmagnitude: The growth rates are similar and the wave numbers are in the same range (0?30 cm1)when the system is unstable. Although in the linear regime the dynamics is affected similarly by thepresence of the indicator and CO2 pressure, in the nonlinear regime, the influence of the latter isclearly more pronounced than the effects of the color indicator.VC 2014 AIP Publishing LLC.","palabras_clave":"instabilities|CO2 dissolution"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38651,"idioma_id":4,"titulo":"Rapid and sensitive detection of Candidatus Liberibacter asiaticus by loop mediated isothermal amplification combined with a lateral flow dipstick","resumen":"Abstract  Background: Citrus Huanglongbing (HLB) is the most devastating bacterial citrus disease worldwide. Three  Candidatus Liberibacter species are associated with different forms of the disease: Candidatus Liberibacter asiaticus,  Candidatus Liberibacter americanus and Candidatus Liberibacter africanus. Amongst them, Candidatus Liberibacter  asiaticus is the most widespread and economically important. These Gram-negative bacterial plant pathogens are  phloem-limited and vectored by citrus psyllids. The current management strategy of HLB is based on early and  accurate detection of Candidatus Liberibacter asiaticus in both citrus plants and vector insects. Nowadays, real time  PCR is the method of choice for this task, mainly because of its sensitivity and reliability. However, this methodology  has several drawbacks, namely high equipment costs, the need for highly trained personnel, the time required to  conduct the whole process, and the difficulty in carrying out the detection reactions in field conditions.  Results: A recent DNA amplification technique known as Loop Mediated Isothermal Amplification (LAMP) was  adapted for the detection of Candidatus Liberibacter asiaticus. This methodology was combined with a Lateral Flow  Dipstick (LFD) device for visual detection of the resulting amplicons, eliminating the need for gel electrophoresis.  The assay was highly specific for the targeted bacterium. No cross-reaction was observed with DNA from any of the  other phytopathogenic bacteria or fungi assayed. By serially diluting purified DNA from an infected plant, the  sensitivity of the assay was found to be 10 picograms. This sensitivity level was proven to be similar to the values  obtained running a real time PCR in parallel. This methodology was able to detect Candidatus Liberibacter asiaticus  from different kinds of samples including infected citrus plants and psyllids.  Conclusions: Our results indicate that the methodology here reported constitutes a step forward in the  development of new tools for the management, control and eradication of this destructive citrus disease. This  system constitutes a potentially field-capable approach for the detection of the most relevant HLB-associated  bacteria in plant material and psyllid vectors","palabras_clave":"HUANGLONGBING|CANDIDATUS LIBERIBACTER ASIATICUS|DIAPHORINA CITRI|MOLECULAR DIAGNOSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38652,"idioma_id":5,"titulo":"Tecnologías de la Información y la Comunicación (TIC) y docencia: nuevos desafíos para la educación actual","resumen":"A pesar de que cada vez, con más énfasis y frecuencia, se pregonan las bondades de la incorporación de las Tecnologías de la Información y las Comunicaciones (TIC) en la enseñanza, la realidad está muy lejos de lo que se enuncia. En este trabajo el objetivo ha sido indagar sobre las concepciones que los\/las docentes tienen sobre las TIC y la manera en que las aplican en el salón de clases. Para examinar estas cuestiones, se realizó un Análisis del Discurso (AD) de las opiniones de tres docentes de ciencias exactas y naturales, sobre la importancia que le asignan a las TIC, y los nuevos desafíos de la educación en la sociedad actual. Los resultados del análisis muestran que, si bien desde el discurso se enfatiza la necesidad de las TIC en la escuela, la realidad es que a los\/as docentes les cuesta mucho aplicarlas en el aula.","palabras_clave":"TECNOLOGÍAS DE LA INFORMACIÓN|CAPACITACIÓN DOCENTE|SOCIEDAD DE LA INFORMACIÒN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38653,"idioma_id":4,"titulo":"- A lipid-mediated conformational switch modulates the thermosensing activity of DesK","resumen":"The thermosensor DesK is a multipass transmembrane protein that allows the bacterium Bacillus subtilis to adjust the levels of unsaturated fatty acids required to optimize membrane lipid fluidity. The cytoplasmic catalytic domain of DesK behaves as kinase at low temperature and as phosphatase at high temperature. Temperature sensing involves a built-in instability caused by a group of hydrophilic residues located near the amino terminus of the first transmembrane (TM) segment. These residues are buried in the lipid phase at low temperature and partially buoy to the aqueous phase at higher temperature with the thinning of the membrane, promoting the required conformational change. Nevertheless, the core question: how is the information sensed by the transmembrane region converted into a rearrangement in the cytoplasmic catalytic domain to control DesK activity? remains poorly understood. Here we identify a linker region (KSRKERERLEEK) that connects the TM sensor domain with the cytoplasmic catalytic domain involved in signal transmission. The linker adopts two conformational states in response to temperature-dependent membrane thickness changes: i) random coiled and bound to the phospholipid head groups at the water-membrane interface, promoting the phosphatase state or ii) unbound and forming a continuous helix spanning a region from the membrane to the cytoplasm, promoting the kinase state. Our results uphold the view that the linker is endowed with a helix\/random coil conformational duality that enables it to behave as a transmission switch, with helix disruption decreasing the kinase\/phosphatase activity ratio, as required to modulate the DesK output response.","palabras_clave":"SIGNAL TRANSDUCTION|TRANSMEMBRANE SENSOR|CONFORMATIONAL SWITCH|KINASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38654,"idioma_id":4,"titulo":"Integrable systems on semidirect product Lie groups","resumen":"We study integrable systems on the semidirect product of a Lie group and its Lie algebra as the representation space of the adjoint action. Regarding the tangent bundle of a Lie group as phase space endowed with this semidirect product Lie group structure, we construct a class of symplectic submanifolds equipped with a Dirac bracket on which integrable systems (in the Adler?Kostant?Symes sense) are naturally built through collective dynamics. In doing so, we address other issues such as factorization, Poisson?Lie structures and dressing actions. We show that the procedure becomes recursive for some particular Hamilton functions, giving rise to a tower of nested integrable systems.","palabras_clave":"Integrable systems|Semidirect product Lie groups|Adler-Kostant-Symes theory|Dirac method"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38655,"idioma_id":4,"titulo":"Classification of integral modular categories of Frobenius-Perron   dimension $pq^4$ and $p^2q^2$","resumen":"We classify integral modular categories of dimension $pq^4$ and $p^2q^2$ where p andq are distinct primes. We show that such categories are always group-theoretical except forcategories of dimension $4q^2$. In these cases there are well-known examples of non-grouptheoretical categories, coming from centers of Tambara-Yamagami categories and quantumgroups. We show that a non-group-theoretical integral modular category of dimension $4q^2$is equivalent to either one of these well-known examples or is of dimension 36 and is twistequivalentto fusion categories arising from a certain quantum group.","palabras_clave":"fusion category|modular category|group-theoretical fusion category"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38656,"idioma_id":4,"titulo":"Nothofagus forest dynamics and palaeoenvironmental variations during the mid and late Holocene, in southwest Patagonia","resumen":"Southern Patagonia intersects the core of the Southern Westerlies, providing a unique opportunity for palaeo-reconstructions and the implication of past wind variations. There is a strong link between the strength of the westerlies and precipitation, which impacts vegetation communities. The palaeoenvironmental changes that occurred since the middle Holocene to present days are reconstructed from a peat record recovered in Peninsula Avellaneda (50°15&#8242;57&#8243;S; 72°50&#8242;33&#8243;W). Interpretations are based on pollen, charcoal and sediment analyses. Closed Nothofagus forest together with low fire activity characterized the region during the period c. 5500?3500 cal. yr BP, related to an increased in precipitation through an intensification of the  westerlies. After 3500 cal. yr BP, shrub and grass communities became dominant at the expense of Nothofagus forest, suggesting a climatic shift to dry conditions, as a result of weaker westerlies. This patchy forest-steppe vegetation has favoured the occurrence of fire events. Subsequently, Nothofagus forest recovered for a short period between 2000 and 400 cal. yr BP. Then, major vegetation changes took place with the re-establishment of an open landscape. The calculated moisture balance index allowed us to hypothesize about the relationship between westerlies fluctuation and El Niño Southern Oscillation (ENSO) anomalies during the mid and late Holocene.","palabras_clave":"FIRE REGIME, |MIDLATE HOLOCENE, |POLLEN ANALYSIS|PALAEOENVIRONMENTAL RECONSTRUCTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38657,"idioma_id":4,"titulo":"First record of the invasive red alga Polysiphonia morrowii Harvey (Rhodomelaceae, Rhodophyta) on the Patagonian shores of the Southwestern Atlantic","resumen":"Seaweed invasions are recognized as one of the  major threats to biological diversity and coastal resources.  Nevertheless, the number of introduced macroalgae has  been underestimated due to the increasing number of  cryptic invasions. Polysiphonia morrowii is native to the  North Pacific and several cryptic introductions of this  species have been reported over the past decade. In this  study, we recorded the presence of the invasive P. morrowii  in the Southwestern Atlantic (Patagonia Argentina)  using a morphological and molecular approach for  the identification at species level. Polysiphonia morrowii  specimens from Argentina showed no morphological differences  from members of invasive populations in France.  We found two different haplotypes, suggesting that P. morrowii  was probably introduced into this area by multiple  introduction events. The increasing number of shipping  and aquaculture activities worldwide and the ability of  this species to be a successful invader suggest that P. morrowii  is likely to be a cosmopolitan invasive species and  that further management planning is required for its early  detection and control.","palabras_clave":"CRYPTIC INVASIONS|POLYSIPHONIA MORROWII|SOUTHWESTERN ATLANTIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38658,"idioma_id":4,"titulo":"Mycobacterium tuberculosis Multidrug Resistant Strain M Induces an Altered Activation of Cytotoxic CD8+ T Cells","resumen":"In human tuberculosis (TB), CD8+ T cells contribute to host defense by the release of Th1 cytokines and the direct killing of Mycobacterium tuberculosis (Mtb)-infected macrophages via granule exocytosis pathway or the engagement of receptors on target cells. Previously we demonstrated that strain M, the most prevalent multidrug-resistant (MDR) Mtb strain in Argentine, is a weak inducer of IFN-&#947; and elicits a remarkably low CD8-dependent cytotoxic T cell activity (CTL). In contrast, the closely related strain 410, which caused a unique case of MDR-TB, elicits a CTL response similar to H37Rv. In this work we extend our previous study investigating some parameters that can account for this discrepancy. We evaluated the expressions of the lytic molecules perforin, granzyme B and granulysin and the chemokine CCL5 in CD8+ T cells as well as activation markers CD69 and CD25 and IL-2 expression in CD4+ and CD8+ T cells stimulated with strains H37Rv, M and 410. Our results demonstrate that M-stimulated CD8+ T cells from purified protein derivative positive healthy donors show low intracellular expression of perforin, granzyme B, granulysin and CCL5 together with an impaired ability to form conjugates with autologous M-pulsed macrophages. Besides, M induces low CD69 and IL-2 expression in CD4+ and CD8+ T cells, being CD69 and IL-2 expression closely associated. Furthermore, IL-2 addition enhanced perforin and granulysin expression as well as the degranulation marker CD107 in M-stimulated CD8+ T cells, making no differences with cells stimulated with strains H37Rv or 410. Thus, our results highlight the role of IL-2 in M-induced CTL activity that drives the proper activation of CD8+ T cells as well as CD4+ T cells collaboration.","palabras_clave":"MYCOBACTERIUM TUBERCULOSIS| IL-2|CD8+ T cells|MULTIDRUG RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38659,"idioma_id":5,"titulo":"Rat liver antioxidant response to iron and copper overloads","resumen":"Abstract  The rat liver antioxidant response to Fe and Cu overloads (0-60 mg\/kg) was studied. Doseand  time-responses were determined and summarized by t1\/2 and C50, the time and the liver  metal content for half maximal oxidative responses. Liver GSH (reduced glutathione) and  GSSG (glutathione disulfide) were determined. The GSH content and the GSH\/GSSG ratio  markedly decreased after Fe (58-66%) and Cu (79-81%) loads, with t1\/2 of 4.0 and 2.0 h.  The C50 were in a similar range for all the indicators (110-124 &#956;g Fe\/g and 40-50 &#956;g Cu\/g)  and suggest a unique free-radical mediated process. Hydrophilic antioxidants markedly  decreased after Fe and Cu (60-75%; t1\/2: 4.5 and 4.0 h). Lipophilic antioxidants were also  decreased (30-92%; t1\/2: 7.0 and 5.5 h after Fe and Cu. Superoxide dismutase (SOD)  activities (Cu,Zn-SOD and Mn-SOD) and protein expression were adaptively increased  after metal overloads (Cu,Zn-SOD: t1\/2: 8-8.5 h and Mn-SOD: t1\/2: 8.5-8.0 h. Catalase  activity was increased after Fe (65%; t1\/2: 8.5 h) and decreased after Cu (26%; t1\/2: 8.0 h),  whereas catalase expression was increased after Fe and decreased after Cu overloads.  Glutathione peroxidase activity decreased after metal loads by 22-39% with a t1\/2 of 4.5 h  and with unchanged protein expression. GSH is the main and fastest responder antioxidant  in Fe and Cu overloads. The results indicate that thiol (-SH) content and antioxidant  enzyme activities are central to the antioxidant defence in the oxidative stress and damage  after Fe and Cu overloads.","palabras_clave":"Iron|Copper|Glutathione|Antioxidants|Liver chemiluminescence|oxidative damage."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38660,"idioma_id":4,"titulo":"A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice","resumen":"Epilepsy is recognized as one of the most common and serious neurological disorder affecting 1-2% of the world?s population. The present study demonstrates that systemic administration of N-butyl-1,2,3-oxathiazolidine-4-one-2,2-dioxide (DIOXIDE), a synthetic compound bioisoster of trimethadione and phenytoin (classical anticonvulsants), elicits a dose dependent anticonvulsant response in mice submitted to the subcutaneous pentylenetetrazole seizure test (scPTZ). Among various factors supposed to play role in epilepsy, oxidative stress and reactive species in seizure disorders have recently emerged. The protection exerted by DIOXIDE over the extent of brain oxidative damage produced by PTZ was determined, by measuring the levels of lipid peroxidation and reduced glutathione and the activity of Na+\/K+-ATPase.  Psychiatric disorders represent frequent comorbidities in persons with epilepsy. In this report, the potential anxiolytic and antidepressant activities of DIOXIDE were evaluated in several widely used models for assessing anxiolytic and antidepressant activities in rodents. Although DIOXIDE did not evidence anxiolytic activity at the doses tested, it revealed an outstanding antidepressant effect. Preliminary studies of its mechanism of action, by means of its capacity to act via the GABAA receptor (using the [3H]flunitrazepam binding assay in vitro and the picrotoxin test in vivo) and the Na+ channel (using the alkaloid veratrine, a voltage-Na+ channel agonist) demonstrated that the anticonvulsant effect is not closely related to the GABAergic pathway and the antidepressant-like effect could be due to its Na+ channel blocking properties.  DIOXIDE is a new anticonvulsant-antioxidant and antidepressant compound that deserves further investigation.","palabras_clave":"3-BUTYL-5,5-DIMETHYL-1,2,3-OXATHIAZOLIDINE-4-ONE-2,2-DIOXIDE|ANTICONVULSANT|OXIDATIVE DAMAGE|ANTIDEPRESSANT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38661,"idioma_id":5,"titulo":"CAMINOS PARA SEDUCIR A HELENA. O LAS PROPUESTAS RETÓRICAS DE GORGIAS, PLATÓN Y ARISTÓTELES","resumen":"En el presente trabajo intento mostrar cómo la disputa de posiciones entre Gorgias y Platón por el lugar del &#955;&#8057;&#947;&#959;&#962;, su potencia y el derecho a su uso se articulan en dos textos clave (especial pero no exclusivamente): Encomio de Helena y Fedro, respectivamente. Para ello será analizado que el papel que adjudican a los elementos emotivos-afectivos resulta la piedra de toque a partir de la cual la retórica sofística gorgiana y la retórica filosófica platónica mostrarán claramente sus divergencias. Por último, haré alusión a la postura que asume Aristóteles frente a esta herencia en Retórica a través de su planteo de tres medios de prueba (&#7974;&#952;&#959;&#962;, &#960;&#8049;&#952;&#959;&#962;, &#955;&#8057;&#947;&#959;&#962;), de igual importancia para lograr persuasión.","palabras_clave":"RETÓRICA|GORGIAS|PLATÓN|ARISTÓTELES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38662,"idioma_id":4,"titulo":"TOPPING PROCESS USING DIFFERENT METHODOLOGIES","resumen":"The first process which crude oil undergoes in a refinery is the atmospheric distillation o topping, whose aim is to fraction the crude oil in their products: naphtha, kerosene, gas oil, etc. The stages involved are: process analysis, carrying out laboratory analysis, identification of parameters, determination of operating conditions and analysis of operating procedures, data processing, stationary simulation and development of results. The column to simulate consists of a rectification column with three side separators and a condenser. For  modeling this process a conventional procedure was performed using the Excel spreadsheet. And for simulating stationary was used HYSYS software. First the crude was characterized by laboratory analysis. Starting from   these analyses, the TBP curve was built and global properties of crude were defined. Resolved the crude oil physicochemical, a model of the column was built. The stationary states found from simulation were compared with the results of the conventional procedure; the comparison had an acceptable degree of consistency. Finally,  a series of alternatives were studied for the design and operating conditions. By resolving the designing process of the topping column, the advantages and disadvantages of a simulator can be compared with a conventional  resolution method.","palabras_clave":"Atmospheric Distillation|Crude Oil Plant|HYSYS|Model Simulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38663,"idioma_id":5,"titulo":"Etanol e Isopropanol: genotoxicidad y teratogénesis evaluada aplicando el modelo de Drosophila melanogaster","resumen":"Resumen: El etanol y el isopropanol son, de los alcoholes alifáticos de cadena corta, los más frecuentemente asociados a la actividad humana tanto a nivel industrial como en el entorno doméstico. En este trabajo se presentan los principales hallazgos reportados en la literatura para ensayos de genotoxicidad y teratogénesis en modelos experimentales de distinto nivel de complejidad, con especial énfasis en Drosophila melanogaster. El metabolismo de estos alcoholes es semejante en Drosophila y en humanos por lo cual la mosca es un buen modelo in vivo para la evaluación de sus potenciales efectos tóxicos, genotóxicos y teratogénicos. Palabras clave: Etanol; Isopropanol; Genotoxicidad, Teratogénesis;  Abstract: Ethanol and isopropanol are two of the short chain aliphatic alcohols more frequently associated to the human environment, both in the industrial and domestic conditions. The aim of this work is to present the main findings reported in the literature about their genotoxicity and teratogenicity in experimental models of different level of complexity, with special emphasis in Drosophila melanogaster. Taking into account that the metabolism of both alcohols in Drosophila and humans is similar, the fly is a good model for the evaluation of their potentially toxic, genotoxic and teratogenic effects.","palabras_clave":"EThANOL|ISOPROPANOL| GENOTOXICITY|TERATOGENICITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38664,"idioma_id":4,"titulo":"Multiple sex chromosome systems in howler monkeys (Platyrrhini, Alouatta)","resumen":"In light of the multiple sex chromosome systems observed in howler monkeys (Alouatta Lacépède,   1799) a combined cladistic analysis using chromosomal and molecular   characters was applied to discuss the possible origin of these systems.   Mesoamerican and South American howlers were karyologically compared.   FISH analysis using the chromosome painting probes for the #3 and #15   human chromosomes was applied to corroborate the homeology of the sexual   systems. We found that the HSA3\/15 syntenic association, present in the   sex chromosome systems of South American Howlers, is not present in   those of Mesoamerican ones. The autosomes involved in the translocation   that formed the sexual systems in the Mesoamerican and South American   species are different, thus suggesting an independent origin. Parsimony   analysis resolved the phylogenetic relationships among howler species,   demonstrating utility of the combined approach. A hypothesis for the   origin of the multiple sex chromosome systems for the genus is proposed.","palabras_clave":"MULTIPLE SEX CHROMOSOME SYSTEMS|COMBINED PHYLOGENETICS ANALYSIS|NEOTROPICAL PRIMATES|ALOUATTA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38665,"idioma_id":4,"titulo":"Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis","resumen":"Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the causative agent of human tuberculosis, has developed several strategies involving proteins and other compounds known collectively as virulence factors to subvert human host defences and invade the human host. The Mce proteins are among these virulence-related proteins and are encoded by the mce1, mce2, mce3 and mce4 operons in the genome of M.&nbsp;tuberculosis. It has been proposed that these operons encode ABC-like lipid transporters; however, the nature of their substrates has only been revealed in the case of the Mce4 proteins. Here we found that the knockout of the mce1 operon alters the lipid profile of M.&nbsp;tuberculosis H37Rv and the uptake of palmitic acid. Thin layer chromatography and liquid chromatography-mass spectrometry analysis showed that the mce1 mutant accumulates more mycolic acids than the wild type and complemented strains. Interestingly, this accumulation of mycolic acid is exacerbated when bacteria are cultured in the presence of palmitic acid or arachidonic acid. These results suggest that the mce1 operon may serve as a mycolic acid re-importer","palabras_clave":"Lipids|Mycobacterium tuberculosis|mycolic acids |Mce proteins"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38666,"idioma_id":4,"titulo":"Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by  estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced  cytotoxicity.","resumen":"ABC transporters including MRP2, MDR1 and BCRP play a major role in tissue defense. Epidemiological and experimental studies suggest a cytoprotective role of estrogens in intestine, though the mechanism remains poorly understood. We evaluated whether pharmacologic concentrations of ethynylestradiol (EE, 0.05pM to 5nM), or concentrations of genistein (GNT) associated with soy ingestion (0.1-10&#956;M), affect the expression and activity of multidrug resistance proteins MRP2, MDR1 and BCRP using Caco-2 cells, an in vitro model of intestinal epithelium. We found that incubation with 5pM EE and 1&#956;M GNT for 48h increased expression and activity of both MRP2 and MDR1. Estrogens did not affect expression of BCRP protein at any concentration studied. Irrespective of the estrogen tested, up-regulation of MDR1 and MRP2 protein was accompanied by increased levels of MDR1 mRNA, whereas MRP2 mRNA remained unchanged. Cytotoxicity assays demonstrated association of MRP2 and MDR1 up-regulation with increased resistance to cell death induced by 1-chloro-2,4-dinitrobenzene, an MRP2 substrate precursor, and by paraquat, an MDR1 substrate. Experiments using an estrogen receptor (ER) antagonist implicate ER participation in MRP2 and MDR1 regulation. GNT but not EE increased the expression of ER&#946;, the most abundant form in human intestine and in Caco-2 cells, which could lead in turn to increased sensitivity to estrogens. We conclude that specific concentrations of estrogens can confer resistance against cytotoxicity in Caco-2 cells, due in part to positive modulation of ABC transporters involved in extrusion of their toxic substrates. Although extrapolation of these results to the in vivo situation must be cautiously done, the data could explain tentatively the cytoprotective role of estrogens against chemical injury in intestine.","palabras_clave":"ETHYNYLESTRADIOL|GENISTEIN|MULTIDRUG RESISTANCE|CACO-2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38667,"idioma_id":4,"titulo":"Genetic diversity and population structure of the mistletoe Tristerix corymbosus (Loranthaceae)","resumen":"The genetic structure of a plant species is influenced by life-history traits, geographical range and ecological interactions that shape gene flow. We examined the genetic structure of the South American mistletoe Tristerix corymbosus using random amplification of polymorphic DNA (RAPD).&nbsp; This species is found mainly in Chile and inhabits two biomes, the Chilean matorral and the temperate forest.&nbsp; The main pollinator agent, a hummingbird, is the same across the whole range, but the disperser assemblage varies between biomes. We selected 22 populations, eight of which were located in the Chilean matorral, where fruits are yellow and birds act as seed dispersers, and 14 populations in the temperate forest, where fruits are green and a marsupial disperses the mistletoe seeds. A total of 10 primers were used to generate amplification products for 121 individuals (ca. six individuals per population) and 91 bands were scored. Results show that this mistletoe species is highly variable with 81% of the bands polymorphic and a Shannon´s diversity index among populations of 0.634. The temperate forest shows slightly higher diversity indices than the Chilean matorral. The central region of the mistletoe geographic range was more variable than the north and the south regions, suggesting that it is a genetically mixed zone. It is likely that gene flow occurs mainly via hummingbirds moving pollen between biomes and birds moving seeds from north to south during spring migrations.","palabras_clave":"SEED DISPERSER|CHILEAN MATORRAL|GENETIC VARIATION|PARASITIC PLANT|POPULATION GENETICS|RAPD|TEMPERATE FOREST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38668,"idioma_id":4,"titulo":"Interactions of the fatty acid-binding protein ReP1-NCXSQ with lipid membranes. Influence of the membrane electric field on binding and orientation","resumen":"The regulatory protein of the squid nerve sodium calcium exchanger (ReP1-NCXSQ) is a 15 kDa soluble, intracellular protein that regulates the activity of the Na+\/Ca 2+ exchanger in the squid axon. It is a member of the cellular retinoic acid-binding proteins family and the fatty acid-binding proteins superfamily. It is composed of ten beta strands defining an inner cavity and a domain of two short alpha helix segments. In this work, we studied the binding and orientation of ReP1-NCXSQ in anionic and zwitterionic lipid membranes using molecular dynamics (MD) simulations. Binding to lipid membranes was also measured by filtration binding assay. ReP1-NCXSQ acquired an orientation in the anionic membranes with the positive end of the macrodipole pointing to the lipid membrane. Potential of mean force calculations, in agreement with experimental measurements, showed that the binding to the anionic interfaces in low ionic strength was stronger than the binding to anionic interfaces in high ionic strength or to zwitterionic membranes. The results of MD showed that the electrostatic binding can be mediated not only by defined patches or domains of basic residues but also by a global asymmetric distribution of charges. A combination of dipole?electric field interaction and local interactions determined the orientation of ReP1-NCXSQ in the interface.","palabras_clave":"Protein Lipid Interaction|Molecular Dinamics Simulations|Electrostatic Interaction|Dipole Moment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38669,"idioma_id":4,"titulo":"Inoculation with Pseudomonas putida PCI2, a phosphate solubilizing rhizobacterium,  stimulates the growth of tomato plants.","resumen":"The use of phosphate solubilizing plant growth-promoting microorganisms as inoculants assists in the hydrolysis of insoluble forms of phosphorus leading to increased plant growth. Pseudomonas putida PCI2 was evaluated for phosphatase activity and solubilization of AlPO4 and FePO4. The effect of different incubation temperatures, concentrations of NaCl and different pH on growth of PCI2 and P solubilization was studied. PCI2 proved to be positive for phosphatase activity, solubilized AlPO4 and hydrolyzed Ca3(PO4)2 even in medium with 5% NaCl. In addition, PCI2 produced 45% units of siderophores. The production of IAA by PCI2 was stimulated in vitro by the addition of different concentrations of L-tryptophan to the culture medium. Assays with tomato seedlings showed that the length of the root was reduced as the concentration of IAA increased. On the other hand, inoculation with PCI2 caused a clear growth-promoting effect on shoot growth in the presence of L-tryptophan. P. putida PCI2 is adapted to different environmental conditions and has potential to be developed and used as an inoculant for increasing the growth of tomato plants.","palabras_clave":"PSEUDOMONAS PUTIDA PCI2|PHOSPHATE SOLUBILIZATION|DIFFERENT ENVIRONMENTAL CONDITIONS|INDOLE-3-ACETIC ACID|TOMATO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38670,"idioma_id":4,"titulo":"Neuronal and glial alterations, increased anxiety and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer?s disease","resumen":"In the context of Alzheimer´s disease (AD), hippocampal alterations have been well described in advanced stages of the pathology, when amyloid deposition, inflammation and glial activation occur, but less attention has been directed to studying early brain and behavioral changes. Using an animal model of AD, the transgenic PDAPP-J20 mouse at 5 months of age, when no amyloid plaques are present and low cerebral levels of amyloid peptides are detectable, we found structural, morphological, and cellular alterations in the hippocampus. Young transgenic mice showed a reduced hippocampal volume with less number of pyramidal and granular neurons, which additionally exhibited cell atrophy. The neurogenic capability in this zone, measured as DCX+ cells, was strongly diminished and associated to alterations in cell maturity. A decrease in presynaptic synaptophysin optical density was detected in mossy fibers reaching CA3 subfield but not in Golgi stained- CA1 dendritic spine density. Employing confocal microscopy and accurate stereological tools we also found a reduction in the number of GFAP+ cells, along with decreased astrocyte complexity, suggesting a potential detriment of neural support. According with untimely neuroglial alterations, young PDAPP mice failed in the novel location recognition test, that depends on hippocampal function. Moreover, multivariate statistical analysis of the behavioral outcome in the open-field test evidenced an elevated anxiety score in Tg mice compared with age-matched control mice. In line with this, the transgenic group showed a higher number of c-Fos+ nuclei in central and basolateral amygdala, a result that supports the early involvement of the emotionality factor in AD pathology. Applying an integrative approach, this work focuses on early structural, morphological and functional changes and provides new and compelling evidence of behavioral alterations that precede manifest AD.","palabras_clave":"Alzheimer|Glia|Hippocampus|Memory"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38671,"idioma_id":5,"titulo":"ALTERACIONES HIPOCAMPALES Y CAMBIOS COGNITIVOS PRECEDEN AL DEPOSITO DE PLACAS AMILOIDES EN UN MODELO DE LA ENFERMEDAD DE ALZHEIMER*","resumen":"Existen múltiples evidencias de alteraciones neuronales y gliales en etapas avanzadas de la enfermedad de Alzheimer con abundantes depósitos cerebrales de beta amiloide, aunque hay pocos datos de cambios tempranos que podrían contribuir al desarrollo de la enfermedad. Evaluamos alteraciones morfológicas neuronales y gliales y cambios cognitivos y emocionales tempranos en ratones transgénicos PDAPP-J20 (Tg), portadores del gen humano de APP mutado, a los 5 meses de edad, aún sin depósitos amiloides en el hipocampo y con niveles bajos de péptidos amiloides cerebrales. Mediante inmunohistoquímica para NeuN, los Tg presentaron menor número de neuronas piramidales y granulares en el hipocampo, junto con un menor volumen de la estructura, en comparación con los controles no transgénicos. La neurogénesis se encontró afectada, evidenciada por un reducido número de neuronas DCX+ en el giro dentado. En la región CA3, hay una menor densidad de sinaptofisina sugiriendo alteraciones sinápticas entre neuronas granulares y piramidales, sin cambios en la densidad de espinas dendríticas en CA1. Utilizando microscopía confocal, observamos una disminución del número de astrocitos GFAP+ junto con una reducción de la complejidad celular, sugiriendo atrofia glial. Se detectó un déficit cognitivo (reconocimiento de localización novedosa de un objeto) y un aumento de la ansiedad (campo abierto) en los Tg, con aumento en los núcleos c-Fos+ en amígdala, evidenciando el papel de la emocionalidad en los inicios de la enfermedad. El estudio de las alteraciones iniciales en la enfermedad amiloide podría contribuir al desarrollo de métodos de diagnóstico temprano y de terapéutica preventiva.","palabras_clave":"Enfermedad de Alzheimer|Hipocampo|Glía|Memoria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38672,"idioma_id":4,"titulo":"An algorithm for the robust exponential stabilization of a class of switched systems","resumen":"In this paper, we consider continuous-time switched systems whose   subsystems are linear, or, more generally, homogeneous of degree one.   For that class of systems, we present a control algorithm that under   certain conditions generates switching signals that globally   exponentially stabilizes the switched system, even in the case in which   there are model uncertainties and\/or measurement errors, provided that   the bounds of that uncertainties and errors depend linearly on the norm   of the state of the system and are small enough in a suitable sense. We   also show that in the case in which the measurement errors and the model   uncertainties are bounded, the algorithm globally exponentially   stabilizes the system in a practical sense, with a final error which   depends linearly on the bounds of both the model uncertainties and the   measurement errors. In other words, the closed-loop system is   exponentially input-to-state-stable if one considers the perturbations   and output measurements bounds as inputs. For switched linear systems,   under mild observability conditions, we design an observer whose   state-estimation drives the control algorithm to exponentially stabilize   the system in absence of perturbations and to stabilize it in an   ultimately bounded way when the perturbations and the output measurement   errors are bounded. Finally, we illustrate the behavior of the   algorithm by means of simulations.","palabras_clave":"ISS|OBSERVERS|STABILIZATION|SWITCHED SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38673,"idioma_id":4,"titulo":"SYNTHESIS, PHYSICOCHEMICAL CHARACTERIZATION, DFT CALCULATION AND BIOLOGICAL ACTIVITIES OF FE (III) AND CO (II) OMEPRAZOLE COMPLEXES. POTENTIAL APPLICATION IN THE HELICOBACTER PYLORI ERADICATION","resumen":"The reaction between the antiulcer agent omeprazole (OMZ) with Fe(III) and Co(II) ions was studied, observing a high ability to form metal complexes. The isolated microcrystalline solid complexes were characterized by elemental analysis, X-ray powder diffraction (XRPD), Scanning Electron Microscopy (SEM), magnetic measurements, thermal study, FTIR, UV?Visible, Mössbauer, electronic paramagnetic resonance (EPR), and DFT calculations. The metal?ligand ratio for both complexes was 1:2 determined by elemental and thermal analysis. FTIR spectroscopy showed that OMZ acts as a neutral bidentate ligand through the pyridinic nitrogen of the benzimidazole ring and the oxygen atom of the sulfoxide group, forming a five-membered ring chelate. Electronic, Mössbauer, and EPR spectra together with magnetic measurements indicate a distorted octahedral geometry around the metal ions, where the coordination sphere is completed by two water molecules. SEM and XRPD were used to characterize the morphology and the crystal nature of the complexes. The most favorable conformation for the Fe(III)?OMZ and Co(II)?OMZ complexes was obtained by DFT calculations by using B3LYP\/6-31G(d)&amp;LanL2DZ\/\/B3LYP\/3-21G(d)&amp;LanL2DZ basis set. Studies of solubility along with the antibacterial activity against Helicobacter pylori for OMZ and its Co(II) and Fe(III) complexes are also reported. Free OMZ and both metal complexes showed antibacterial activity against H. pylori. Co(II)?OMZ presented a minimal inhibitory concentration 32 times lower than that of OMZ and 65 lower than Fe(III)?OMZ, revealing its promising potential use for the treatment of gastric pathologies associated with the Gram negative bacteria. The morphological changes observed in the cell membrane of the bacteria after the incubation with the metal-complexes were also analyzed by SEM microscopy. The antimicrobial activity of the complexes was proved by the viability test.","palabras_clave":"Metal-drug complexes|Omeprazole|Iron(III)|Cobalt(II)"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38674,"idioma_id":4,"titulo":"Globular Clusters: DNA of Early-Type galaxies?","resumen":"This paper explores if the mean properties of Early-Type Galaxies (ETG) can be reconstructed from ?genetic? information stored in their GCs (i.e., in their chemical abundances, spatial distributions and ages). This approach implies that the formation of each globular occurs in very massive stellar environments, as suggested by some models that aim at explaining the presence of multi-populations in these systems. Theassumption that the relative number of globular clusters to diffuse stellar mass depends exponentially on chemical abundance, [Z\/H], and the presence of two dominant GC sub-populations (blue and red), allows the mapping of low metallicity halos and of higher metallicity (and more heterogeneous) bulges. In particular, the masses of the low-metallicity halos seem to scale up with dark matter mass through a constant.We also find a dependence of the globular cluster formation efficiency with the mean projected stellar mass density of the galaxies within their effective radii. The analysis is based on a selected sub-sample of galaxies observed within the ACS Virgo Cluster Survey of the Hubble Space Telescope. These systems were grouped, according to their absolute magnitudes, in order to define composite fiducial galaxies and look for aquantitative connection with their (also composite) globular clusters systems. The results strengthen the idea that globular clusters are good quantitative tracers of both baryonic and dark matter in ETGs.","palabras_clave":"galaxies|globular clusters|halos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38675,"idioma_id":4,"titulo":"Composite Retrieval of Diverse and Complementary Bundles","resumen":"Users are often faced with the problem of finding complementary items that together achieve a single common goal (e.g., a starter kit for a novice astronomer, a collection of question\/answersrelated to low-carb nutrition, a set of places to visit on holidays).In this article, we argue that for some application scenarios returning item bundles is more appropriate than ranked lists. Thus we define composite retrieval as the problem of finding k bundles of complementary items. Beyond complementarity of items, the bundles must be valid w.r.t. a given budget, and the answer set of k bundles must exhibit diversity.We formally define the problem and characterize its complexity. We prove that the problem in its general form is NP-hard and that also the special cases in which each bundle is formed by only one item, or only one bundle is sought, are hard. Our characterization however suggests us how to adopt a two-phase approach (Produceand-Choose, or PAC) in which we first produce many valid bundles, and then we choose k among them. For the first phase we devise two ad-hoc clustering algorithms, while for the second phase we adapt heuristics with approximation guarantees for a related problem.We also devise another approach which is based on first finding a k-clustering and then selecting a valid bundle from each of the produced clusters (Cluster-and-Pick, or CAP).We compare experimentally the proposed methods on two realworld datasets, exploring their performance under a variety of settings.The first dataset is given by a sample of touristic attractions in ten large European cities, while the second is a large database of user-generated restaurant reviews from Yahoo! Local. Our experiments show that when diversity is highly important, CAP is the best option, while when diversity is less important, a PAC approach constructing bundles around randomly chosen pivots, is better.","palabras_clave":"COMPOSITE RETRIEVAL|COMPLEMENTARITY|DIVERSITY|MAXIMUN EDGE SUBGRAPH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38676,"idioma_id":4,"titulo":"Spectroscopic and DFT study of solvent effects on the electronic absorption spectra of sulfamethoxazole in neat and binary solvent mixtures","resumen":"The solvatochromic behavior of sulfamethoxazole (SMX) was investigated using UV?vis spectroscopy and DFT methods in neat and binary solvent mixtures. The spectral shifts of this solute were correlated with the Kamlet and Taft parameters (a, b and p). Multiple lineal regression analysis indicates that both specific hydrogen-bond interaction and non specific dipolar interaction play an important role in the position of the absorption maxima in neat solvents. The simulated absorption spectra using TD?DFT methods were in good agreement with the experimental ones. Binary mixtures consist of cyclohexane (Cy)-ethanol (EtOH), acetonitrile (ACN)-dimethylsulfoxide (DMSO), ACN?dimethylformamide (DMF), and aqueous mixtures containing as co-solvents DMSO, ACN, EtOH and MeOH. Index of preferential solvation was calculated as a function of solvent composition and non-ideal characteristics are observed in all binary mixtures. In ACN?DMSO and ACN?DMF mixtures, the results show that the solvents with higher polarity and hydrogen bond donor ability interact preferentially with the solute. In binary mixtures containing water, the SMX molecules are solvated by the organic co-solvent (DMSO or EtOH) over the whole composition range. Synergistic effect is observed in the case of ACN?H2O and MeOH?H2O, indicating that at certain concentrations solvents interact to form association complexes, which should be more polar than the individual solvents of the mixture.","palabras_clave":"Sulfamethoxazole|UVvis spectroscopy|Solvatochromism|LSER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38677,"idioma_id":4,"titulo":"UV-vis spectroscopic study and DFT calculation on the solvent effect of trimethoprim in neat solvents and aqueous mixtures","resumen":"The solvatochromic behavior of trimethoprim (TMP) was analyzed using UV?Vis spectroscopy and DFT methods in neat and binary aqueous solvent mixtures. The effects of solvent dipolarity\/polarizability and solvent?solute hydrogen bonding interactions on the absorption maxima were evaluated by means of the linear solvation energy relationship concept of Kamlet and Taft. This analysis indicated that both interactions play an important role in the position of the absorption maxima in neat solvents. The simulated absorption spectra of TMP and TMP:(solvent)n complexes in ACN and H2O using TD-DFT methods were in agreement with the experimental ones. Binary aqueous mixtures containing as co-solvents DMSO, ACN and EtOH were studied. Preferential solvation was detected as a nonideal behavior of the wavenumber curve respective to the analytical mole fraction of co-solvent in all binary systems. TMP molecules were preferentially solvated by the organic solvent over the whole composition range. Index of preferential solvation, as well as the influence of solvent parameters were calculated as a function of solvent composition.","palabras_clave":"Trimethoprim|UV?Vis spectroscopy|Solvatochromism|TD-DFT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38678,"idioma_id":4,"titulo":"Differential Migration and Activation Profile of Monocytes after Trophoblast Interaction","resumen":"Macrophages at the maternal-placental interface coordinate opposite demands under the control of trophoblast cells such as the response against pathogens on one hand, and apoptotic cell clearance and wound healing with the production of suppressor cytokines. Here, we investigated whether trophoblast cells induce maternal monocyte activation towards an alternative activated macrophage profile and whether bacterial or viral stimuli modulate their migratory properties. We used an in vitro model of the maternal-placental interface represented by co-cultures of CD14+ cells isolated from fertile women with first trimester trophoblast cell line (Swan-71 cells) in the presence or absence of pathogen associated molecular pattern (PAMP) stimuli lipopolysaccharide (LPS), peptidoglycan (PGN) or poly [I:C]). Maternal CD14+ cells showed increased CD16 and CD39 expression, both markers associated to an alternative activation profile, with no changes in CD80 expression after trophoblast cell interaction. These changes were accompanied by increased IL-10 and decreased IL-12 production by CD14+ cells. After stimulation with LPS, PGN or poly [I:C], monocytes co-cultured with trophoblast cells had lower production of TNF-a and IL-1b compared with non co-cultured monocytes. Interestingly, monocyte migration towards trophoblast cells was prevented in the presence of LPS or PGN but not after 24h of stimulation with poly [I:C]. LPS or PGN also decreased CCR5, CXCL-8 and CCL5 expression. Finally, trophoblast cells co-cultured with monocytes in the presence of pathological stimuli failed to increase chemokine expression, indicating a bidirectional effect. In conclusion, trophoblast might ?instruct? maternal monocytes to express an alternative activation profile and restrain their early recruitment under pathological threats as one of the first strategies to avoid potential tissue damage at the maternalplacental interface","palabras_clave":"CHEMOKINES|TROPHOBLAST CELLS|INFLAMMATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38679,"idioma_id":4,"titulo":"Central - and -thujone: similar anxiogenic-like effects and differential modulation on gaba a receptors in neonatal chicks","resumen":"The convulsant effects of &#945;-thujone are attributed to inhibitory actions on the GABAA receptor. We investigated, for the first time, the effects of &#945;-thujone or &#946;-thujone administrated centrally on the fear\/anxiety behaviour of 3-day-old chicks in an Open Field and their modulation on the GABAA receptor. Higher doses were convulsant by eliciting a toxic and excitatory action, with the results showing that a dose of 78 nmol of either of the two diastereoisomers had an anxiogenic-like effect observed as an increased latency to ambulate and a reduced locomotor activity in an Open Field. Nevertheless, only the central administration of &#945;-thujone reversed the increase induced by acute stress in the flunitrazepam-sensitive GABAA receptor recruitment. These findings demonstrated that &#945;-thujone, when intracerebroventricularly administered, suppressed the GABAA receptor recruitment induced by acute stress, maybe due to &#945;-thujone blocking the benzodiazepine binding site or another site of the GABAA complex. However, it should not be discarded that acute stress associated with novelty may have induced the recruitment of a subpopulation of GABAA receptors more sensitive to &#945;-thujone than to the constitutive receptors, or that this monoterpene could have inhibited any protein or enzyme trafficking that modulated the phosphorylation of the receptor involved in the turnover of GABAA receptor. &#946;-thujone showed behavioural effects similar to its diastereoisomer &#945;-thujone. However, its action mechanism may have been mediated by other neurotransmitter systems, such as the serotonergic one or by a different biological effectiveness due to a distinct stereochemistry at the specific site of the GABAA receptor.","palabras_clave":"alpha-thujone|beta-thujone|anxiety|GABAA receptorrecruitment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38680,"idioma_id":4,"titulo":"Poly (vinyl alcohol)\/ Cellulose Nanowhiskers nanocomposite hydrogels for potential wound dressings","resumen":"Polyvinyl alcohol (PVA)\/Cellulose nanowhiskers (CNW) nanocomposite hydrogels to be used for wound dressing were obtained by freezing-thawing technique and characterized by means of morphological, physical, thermal, mechanical, barrier and antimicrobial properties. First, cellulose nanowhiskers were obtained by the acid hydrolysis of commercial crystalline microcellulose (MCC) and characterized by its size, shape, morphological, structural and thermal properties. Then, PVA\/CNW nanocomposites with several CNW contents (0, 1, 3, 5 and 7 wt.%) were obtained. Morphological, thermal, chemical and physical characterization of the PVA\/CNW nanocomposite hydrogels was carried out. It was found that the addition of CNW to the hydrogel allows controlling the pore morphology of the samples. On the other hand, the transparency of the samples was maintained, the thermal stability was increased, the mechanical properties were improved and the water vapor transmission rate was in the range of wound dressing applications after CNW incorporation inside the PVA hydrogel matrix. The evaluation of microbial penetration showed that the prepared hydrogels can be considered as a good barrier against different microorganisms. All obtained results indicate that the PVA\/CNW materials are promising to be used as wound dressing.","palabras_clave":"Polymer-Matrix Composites|Nanocomposites|Nano Particles|Composite Hydrogel"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38681,"idioma_id":5,"titulo":"Estudiantes, militantes, activistas. Nuevas agendas de las agrupaciones universitarias en torno al género y la diversidad sexual","resumen":"Perfiles Educativos (México). Indexada en Latindex-Catálogo, Latindex-Directorio, Clase, Conacyt, DIALNET, Directory of Open Access Journals (DOAJ), Iresie, Red ALyC, SciELO y Ulrich´s: http:\/\/www.latindex.unam.mx\/buscador\/ficRev.html?opcion=1&amp;folio=14501 \/\/        El presente artículo analiza la incorporación en la última década de demandas y reivindicaciones provenientes de  los movimientos feministas y de la diversidad sexual en las agendas de las agrupaciones universitarias. Se detiene en los cambios y permanencias en las prácticas políticas estudiantiles, en las estrategias de intervención y en los efectos que esta discursividad política produce en la experiencia estudiantil. Centralmente, esta nueva agenda posibilita la circulación temas que se encuentran por fuera del repertorio instituido por las currículas y los procesos de transmisión del conocimiento, y propicia una crítica a la formación universitaria. Al mismo tiempo, habilita una reflexividad de la dimensión genérica y sexuada de la condición de estudiante que lleva a cuestionar la normatividad sexo genérica en las instituciones universitarias. Este trabajo es el resultado de una investigación desarrollada en las facultades de Psicología y de Ciencias Exactas y Naturales de la Universidad de Buenos Aires.","palabras_clave":"POLITICA|UNIVERSIDAD|GENERO Y SEXUALIDAD|ESTUDIANTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38682,"idioma_id":4,"titulo":"Chirikov and Nekhoroshev diffusion estimates: bridging  the two sides of the river","resumen":"We   present theoretical and numerical results pointing towards a strong     connection between the estimates for the diffusion rate along simple     resonances in multidimensional nonlinear Hamiltonian systems that can     be obtained using the heuristic theory of Chirikov and a more formal     one due to Nekhoroshev. We show that, despite a wide-spread impression,     the two theories are complementary rather than antagonist.   Indeed,   although Chirikov´s 1979 review has thousands of citations,  almost all   of them refer to topics such as the resonance overlap  criterion, fast   diffusion, the Standard or Whisker Map, and not  to the constructive   theory providing a formula to measure diffusion  along a single   resonance. However, as will be demonstrated explicitly  below,   Chirikov´s formula provides values of the diffusion coefficient  which   are quite well comparable to the numerically computed ones,  provided   that it is implemented on the so-called 'optimal normal  form'   derived as in the analytic part of Nekhoroshev´s theorem.  On the other   hand, Chirikov´s formula yields unrealistic values  of the diffusion   coefficient, in particular for very small values  of the perturbation,   when used in the original Hamiltonian instead  of the optimal normal   form.} In the present paper, we take advantage  of this complementarity   in order to obtain accurate theoretical   predictions for the local   value of the diffusion coefficient along a resonance   in a specific   3DoF nearly integrable Hamiltonian system. Besides, we   compute   numerically the diffusion coefficient and a full comparison of  all   estimates is made for ten values of the perturbation  parameter, showing   a very satisfactory agreement.","palabras_clave":"NEKHOROSHEV'S AND CHIRIKOV'S DIFFUSION THEORIES|CHAOS|INSTABILITIES|DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38683,"idioma_id":4,"titulo":"Stochastic approach to diffusion inside the chaotic layer of a resonance","resumen":"We model chaotic di&#64256;usion, in a symplectic 4D map by using the result of a theorem that was  developed for stochastically perturbed integrable Hamiltonian systems. We explicitly consider a map  de&#64257;ned by a free rotator (FR) coupled to a standard map (SM). We focus in the di&#64256;usion process  in the action, I, of the FR, obtaining a semi?numerical method to compute the di&#64256;usion coe&#64259;cient.  We study two cases corresponding to a thick and a thin chaotic layer in the SM phase space and  we discuss a related conjecture stated in the past. In the &#64257;rst case the numerically computed  probability density function for the action I is well interpolated by the solution of a Fokker-Planck  (F-P) equation, whereas it presents a non?constant time delay respect to the concomitant F-P  solution in the second case suggesting the presence of an anomalous di&#64256;usion time scale. The  explicit calculation of a di&#64256;usion coe&#64259;cient for a 4D symplectic map can be useful to understand  the slow di&#64256;usion observed in Celestial Mechanics and Accelerator Physics.","palabras_clave":"CHAOS|DIFFUSION|STOCHASTIC SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38684,"idioma_id":4,"titulo":"'Preparation, anticholinesterase activity and molecular docking of new lupane derivatives'","resumen":"A set of twenty one lupane derivatives (2-22) was prepared from the natural triterpenoid calenduladiol (1) by transformations on the hydroxyl groups at C-3 and C-16, and also on the isopropenyl moiety. The derivatives were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and some structure-activity relationships were outlined with the aid of enzyme kinetic studies and docking modelization. The most active compound resulted to be 3,16,30-trioxolup-20(29)-ene (22), with an IC50 value of 21.5 µM for butyrylcholinesterase, which revealed a selective inhibitor profile towards this enzyme.","palabras_clave":"ALZHEIMER'S DISEASE|CHOLINESTERASE INHIBITORS|LUPANE DERIVATIVES|TRITERPENOIDS|MOLECULAR MODELING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38685,"idioma_id":4,"titulo":"Effects  of  chlorate  on  the  sulfation  process  of  Trypanosoma  cruzi glycoconjugates.  Implication  of  parasite  sulfates  in  cellular  invasion","resumen":"Sulfation, a post-translational modification which plays a key role in various biological processes, is inhibited by competition with chlorate. In Trypanosoma cruzi, the agent of Chagas' disease, sulfated structures have been described as part of glycolipids and we have reported sulfated high-mannose type oligosaccharides in the C-T domain of the cruzipain (Cz) glycoprotein. However, sulfation pathways have not been described yet in this parasite. Herein, we studied the effect of chlorate treatment on T. cruzi with the aim to gain some knowledge about sulfation metabolism and the role of sulfated molecules in this parasite. In chlorate-treated epimastigotes, immunoblotting with anti-sulfates enriched Cz IgGs (AS-enriched IgGs) showed Cz undersulfation. Accordingly, a Cz mobility shift toward higher isoelectric points was observed in 2D-PAGE probed with anti-Cz antibodies. Ultrastructural membrane abnormalities and a significant decrease of dark lipid reservosomes were shown by electron microscopy and a significant decrease in sulfatide levels was confirmed by TLC\/UV-MALDI-TOF-MS analysis. Altogether, these results suggest T. cruzi sulfation occurs via PAPS. Sulfated epitopes in trypomastigote and amastigote forms were evidenced using AS-enriched IgGs by immunoblotting. Their presence on trypomastigotes surface was demonstrated by flow cytometry and IF with Cz\/dCz specific antibodies. Interestingly, the percentage of infected cardiac HL-1 cells decreased 40% when using chlorate-treated trypomastigotes, suggesting sulfates are involved in the invasion process. The same effect was observed when cells were pre-incubated with dCz, dC-T or an anti-high mannose receptor (HMR) antibody, suggesting Cz sulfates and HMR are also involved in the infection process by T. cruzi.","palabras_clave":"Trypanosoma cruzi | chlorate |sulfation|glycoconjugates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38686,"idioma_id":4,"titulo":"Hydrophobicity and geometry: Water at curved graphitic-like surfaces and within model pores in self-assembled monolayers","resumen":"In this work we perform molecular dynamics simulations of water in contact with simple modelhydrophobic surfaces and pores in order to test the role of local geometry on hydrophobicity. Specif-ically, we study different quantities like orientational ordering, density fluctuations and water residencetimes (autocorrelation functions) around graphene sheets, at the exterior of single-walled carbon nano-tubes, at alkane-like self-assembled monolayers (SAMs) and at pores of different sizes carved in suchSAMs. We show that in the case of the convex graphitic-like surfaces, the cuvature does not affect thelocal hydrophobicity. However, significant curvature dependence will be made evident for the concavesurfaces of the pores carved in the SAMs. The geometrically induced dehydration that occurs as the poresize reaches the subnanometric regime might be operative in realistic settings like protein binding siteswhich require water remotion upon ligand binding.","palabras_clave":"HYDROPHOBICITY|WATER|GRAPHENE|NANOTUBES|SAMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38687,"idioma_id":4,"titulo":"Structural order in ultrathin films of the monolayer protected clusters based upon 4 nm gold nanocrystals: an experimental and theoretical study.","resumen":"The structural order in ultrathin films of monolayer protected clusters (MPCs) is important in a number of application areas but can be difficult to demonstrate by conventional methods, particularly when the metallic core dimension, d, is in the intermediate size-range, 1.5 < d < 5.0 nm. Here, improved techniques for the synthesis of monodisperse thiolate-protected gold nanoparticles have made possible the production of dodecane-thiolate saturated ~ 4 ± 0.5 nm Au clusters with single-crystal core structure and morphology. An ultrathin ordered film or superlattice of these nanocrystal-core MPCs is prepared and investigated using aberration corrected scanning\/transmission electron microscopy (STEM) which allowed imaging of long-range hexagonally ordered superlattices of the nanocrystals, separated by the thiolate groups. The lattice constants determined by direct imaging are in good agreement with those determined by small-angle electron diffraction. The STEM image revealed the characteristic grain boundary (GB) with sigma (&#931;) 13 in the interface between two crystals. The formation and structures found are interpreted on the basis of theoretical calculations employing molecular dynamics (MD) simulations and coarse-grained (CG) approach.","palabras_clave":"superlattice|gold nanoparticles|hrtem|simulations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38688,"idioma_id":4,"titulo":"The importance of native and exotic plant identity and dominance on decomposition patterns in mountain woodlands of central Argentina","resumen":"Exotic species can have a strong influence on ecosystem processes, especially when exotic invaders differ from natives in key morpho-functional features. We explored whether exotic species, especially those forming monospecific patches in Chaco montane woodlands, differ from natives in leaf attributes and decomposability. We then evaluated how exotic monospecific patches in that region alter litter decomposability, by weighting leaf trait values and decomposability by species abundance in the communities. In general, native and exotic species from Córdoba Chaco montane woodlands did not differ in leaf attributes (specific leaf area, leaf toughness, and leaf water content), or decomposability. Because of similar trait values and decomposability, we expected to find no differences in litter decomposability between plots dominated by exotic species and those of Native woodland. However, individual species decomposability weighted by species abundance in the communities showed that litter from exotic monospecific plots had slower decomposition than native ones. This pattern was confirmed by the higher decomposability and higher quality of the naturally mixed litter collected from native plots, compared to those collected from exotic plots. Despite the general similarities between most native and exotic species inhabiting Chaco montane woodlands, the overwhelming dominance of some exotic invaders in monospecific stands (and the consequent weight of their attributes on the litter each woodland produces) might be driving differences in decomposition patterns between woodland types. Our results indicate that when estimating the impact of exotic species on ecosystem processes, we should include their relative abundance in the community, as well as the relevance of the traits influencing those processes. Otherwise, we may draw erroneous conclusions.","palabras_clave":"Ligustrum lucidum|Gleditsia triacanthos|Pinnus elliottii|decomposability"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38689,"idioma_id":4,"titulo":"Complete genome sequences of nine mycobacteriophages","resumen":"Genome analyses of a large number of mycobacteriophages, bacterial viruses that infect members of the genus Mycobacterium,yielded novel enzymes and tools for the genetic manipulation of mycobacteria. We report here the complete genome sequencesof nine mycobacteriophages, including a new singleton, isolated using Mycobacterium smegmatis mc2155 as a host strain.","palabras_clave":"GENOME|MYCOBACTERIOPHAGES|COMPLETE SEQUENCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38690,"idioma_id":4,"titulo":"Specificity of Lepidelphax pistiae (Hemiptera: Delphacidae) to Pistia stratiotes (Araceae)","resumen":"The delphacid Lepidelphax pistiae was found on water lettuce in Argentina.Nymphs and adults did not survive past seven days on 29 species of test plants, and no progeny were produced. In contrast, survival and reproduction were high on water lettuce. Results suggest that L. pistiae is monospecific to water lettuce.","palabras_clave":"water lettuce|no-choice tests|aquatic weeds"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38691,"idioma_id":4,"titulo":"Evaluation of intraguild interactions between two species of insect herbivores on Pistia stratiotes","resumen":"Pistia stratiotes L. (Araceae) is an important weed in many waterways around the world. The South American weevil Neohydronomus affinis Hustache (Coleoptera: Curculionidae) is a successful biocontrol agent for this weed but additional agents are needed for some areas. The planthopper Lepidelphax pistiae Remes Lenicov (Hemiptera: Delphacidae) is a specific herbivore of P. stratiotes and is highly damaging in laboratory conditions. A field experiment was designed to evaluate the damage potential of L. pistiae compared to N. affinis and to assess the potential for competition between the two herbivores. Both herbivore species were reared inside floating cages on a P. stratiotes-infested lake. Plant growth indices assessed were clonation levels, biomass and plant diameter. The growth indices of plants exposed to the herbivores, individually and combined, were comparable, and significantly lower than in the control treatments. Population levels of N. affinis inside the cages were not significantly different when alone or together with L. pistae. Conversely, the density of L. pistiae was significantly lower in combination with the weevil. This suggests that L. pistiae is a damaging herbivore that will not reduce the biological control effectiveness of N. affinis.","palabras_clave":"Neohydronomus affinis|Lepidelphax pistiae|Water lettuce|Herbivory"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38692,"idioma_id":4,"titulo":"Analysis of plasmid-mediated quinolone resistance genes in clinical isolates of the tribe Proteeae from Argentina: First report of qnrD in the Americas","resumen":"To analyse the occurrence and prevalence of plasmid-mediated quinolone resistance (PMQR) genes in  the tribe Proteeae, 81 isolates (65 Proteus spp., 12 Morganella morganii and 4 Providencia stuartii)  consecutively collected in 66 hospitals belonging to the WHONET-Argentina Resistance Surveillance  Network were studied. Ofthe 81 isolates, 50 (62%) were susceptible to quinolones [43\/65 (66%) Proteus  spp. and 7\/12 (58%) M. morganii). The remaining 31 isolates (22 Proteus spp., 5 M. morganii and all P.  stuartii) showed high-level resistance to nalidixic acid (NAL) and decreased susceptibility or resistance to  ciprofloxacin. All NAL-resistant isolates harboured mutations associated with quinolone resistance  (MAQRs) in both gyrA (S83I\/R) and parC (S80I\/R), and some also had MAQRs in gyrB (S464Y\/F). The  unique PMQR gene detected was qnrD, which was found in 2\/81 isolates (Proteus mirabilis Q1084 and  Proteus vulgaris Q5169), giving a prevalence of 2.5% in Proteeae. These two isolates were from different  geographical regions and both harboured MAQRs in gyrA and parC. The qnrD genes were located on the  related plasmids pEAD1-1 (2683 bp) and pEAD1-2 (2669 bp). Plasmid pEAD1-1 was 100% identical to  pCGH15 and differed in only three nucleotides from pDIJ09-518a, which were previously found in  clinical isolates of P. mirabilis (China) and Providencia rettgeri (France), respectively, whilst pEAD1-2 was  not previously described. The extended-spectrum b-lactamase CTX-M-2 was found in 27% (22\/81) ofthe  isolates and was significantly associated with quinolone resistance but not with qnrD (only P. mirabilis  Q1084 expressed CTX-M-2). This is the first report of qnrD in the Americas","palabras_clave":"Quinolone|Plasmid-mediated resistance|qnrD|gyrA, gyrB and parC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38693,"idioma_id":4,"titulo":"Electrophoretic Deposition of Gentamicin-Loaded Bioactive Glass\/ 2 Chitosan Composite Coatings for Orthopaedic Implants","resumen":"Despite their widespread application, metallic orthopaedic prosthesis failure still occurs because of lack of adequate bone-bonding and the incidence of post-surgery infections. The goal of this research was to develop multifunctional composite chitosan\/Bioglass coatings loaded with gentamicin antibiotic as a suitable strategy to improve the surface properties of metallic implants. Electrophoretic deposition (EPD) was applied as a single-step technology to simultaneously deposit the biopolymer, bioactive glass particles, and the antibiotic on stainless steel substrate. The microstructure and composition of the coatings were characterized using SEM\/EDX, XRD, FTIR, and TGA\/DSC, respectively. The in vitro bioactivity of the coatings was demonstrated by formation of hydroxyapatite after immersion in simulated body fluid (SBF) in a short period of 2 days. High-performance liquid chromatography (HPLC) measurements indicated the release of 40% of the loaded gentamicin in phosphate buffered saline (PBS) within the first 5 days. The developed composite coating supported attachment and proliferation of MG-63 cells up to 10 days. Moreover, disc diffusion test showed improved bactericidal effect of gentamicin-loaded composite coatings against S. aureus compared to control non-gentamicin-loaded coatings.","palabras_clave":"COATINGS|BIOACTIVE GLASS|CHITOSAN|GENTAMICIN|ELECTROPHORETIC DEPOSITION|DRUG DELIVERY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38694,"idioma_id":4,"titulo":"CORTICOSTERONE AFFECTS THE DIFFERENTIATION OF A NEURONAL CEREBRAL CORTEX-DERIVED CELL LINE THROUGH MODULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR","resumen":"Chronic exposure to stress hormones has an impact on brain structures   relevant to cognition. Nicotinic acetylcholine receptors (AChRs) are   involved in numerous cognitive processes including learning and memory   formation. In order to better understand the molecular mechanisms of   chronic stress-triggered mental disease, the effect of corticosterone   (CORT) on the biology of AChRs was studied in the neuronal cell line   CNh. We found that chronic treatment with CORT reduced the expression   levels of the &#945;7-type neuronal AChR and, to a lesser extent, of &#945;4-AChR.   CORT also delayed the acquisition of the mature cell phenotype in CNh   cells. Chronic nicotine treatment affected the differentiation of CNh   cells and exerted a synergistic effect with CORT, suggesting that AChR   could participate in signaling pathways that control the cell cycle.   Overexpression of &#945;7-AChR-GFP abolished the CORT effects on the cell   cycle and the specific &#945;7-AChR inhibitor, methyllycaconitine, mimicked   the proliferative action exerted by CORT. Whole-cell voltage-clamp   recordings showed a significant decrease in nicotine-evoked currents in   CORT-treated cells. Taken together, these observations indicate that   AChRs, and the &#945;7-AChR in particular, could act as modulators of the   differentiation of CNh cells and that CORT could impair the acquisition   of a mature phenotype by affecting the function of this AChR subtype.","palabras_clave":"nicotine|ion channel|glucocorticoids|cell cycle|stress"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38695,"idioma_id":4,"titulo":".- DIFFUSE LIGHT TRANSMISSION PROFILES OBTAINED USING CW: A COMPARATIVE ANALYSIS WITH TIME RESOLVED EXPERIMENTS","resumen":"In this work, we investigate the CW transmitted light profiles when an inhomogeneity is immersed in highly scattering media slabs. These profiles show an interesting effect whenever the absorption coefficient, &#956;a, of the inclusion happens to be higher than that of the bulk whereas its reduced scattering coefficient, &#956;´s is lower than that of the surrounding medium. For this combination of optical properties, the transmitted light displays a peak of higher intensity at scan positions where the inclusion is located, producing a distinctive ?W? profile. We have investigated this effect by analyzing the temporal windows of the distribution of times of flight at each scan position. In this way we found that the origin of the ?W? profile is due to the contribution of the late photons. Experiments are compared with a theoretical model and with Monte Carlo simulations showing good agreement.","palabras_clave":"TURBID MEDIA|TRANSMITTANCE|INHOMOGENEITIES|TIME RESOLVED TECHNIQUES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38696,"idioma_id":4,"titulo":"Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: role of oxidative stress","resumen":"Abstract: To evaluate whether co-administration of R\/S-alpha-lipoic acid can prevent the development of oxidative stress and metabolic changes induced by a fructose-rich diet (F).METHODS: We assessed glycemia in the fasting state and during an oral glucose tolerance test, triglyceridemia and insulinemia in rats fed with standard diet (control) and fructose without or with R\/S-alpha-lipoic acid. Insulin resistance and hepatic insulin sensitivity were also calculated. In liver, we measured reduced glutathione, protein carbonyl groups, antioxidant capacity by ABTS assay, antioxidant enzymes (catalase and superoxide dismutase 1 and 2), uncoupling protein 2, PPAR delta and PPAR gamma protein expressions, SREBP-1c, fatty acid synthase and glycerol-3-phosphate acyltransferase-1 gene expression, and glucokinase activity.RESULTS: R\/S-alpha-lipoic acid co-administration to F-fed rats a) prevented hyperinsulinemia, hypertriglyceridemia and insulin resistance, b) improved hepatic insulin sensitivity and glucose tolerance, c) decreased liver oxidative stress and increased antioxidant capacity and antioxidant enzymes expression, d) decreased uncoupling protein 2 and PPAR delta protein expression and increased PPAR gamma levels, e) restored the basal gene expression of PPAR delta, SREBP-1c and the lipogenic genes fatty acid synthase and glycerol-3-phosphate acyltransferase, and f) decreased the fructose-mediated enhancement of glucokinase activity. CONCLUSIONS: Our results suggest that fructose-induced oxidative stress is an early phenomenon associated with compensatory hepatic metabolic mechanisms, and that treatment with an antioxidant prevented the development of such changes. GENERAL SIGNIFICANCE: This knowledge would help to better understand the mechanisms involved in liver adaptation to fructose-induced oxidative stress and to develop effective strategies to prevent and treat, at early stages, obesity and type 2 diabetes mellitus.","palabras_clave":"FRUCTOSE|LIVER UNCOUPLING PROTEIN |PPAR REGULATION|GLYCOOXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38697,"idioma_id":4,"titulo":"Image potential state Influence on Charge Exchange in Li+ - Metal Surface Collisions.","resumen":"The energy dependence of the neutral fraction of ions scattered by metal   surfaces is observed to be affected by the presence of energy gaps and   surface states in their surface band structure. The effect is more   dramatic when the ion energy level remains close to the surface Fermi   level of the surface, as it occurs in the scattering of Li positive ions   by Cu and noble metal surfaces. We have incorporated the interaction of   the ion state with the bulk- and surface-like states within an extended   Anderson model and by using an ab initio calculation of the Hamiltonian   terms. In this form we found that the increase of the neutral fraction   at low projectile energies is explained solely by the presence of energy   gaps in the case of Cu(111), while the bonding interaction with the   first image potential state is also important in the Cu(100), Ag(100),   and Ag(111) surfaces.","palabras_clave":"Image States|Charge exchange|Ion-surface collisions"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38698,"idioma_id":4,"titulo":"Genetic Analysis of Tomato Fruit Ripening at Polypeptide Profiles Level through Quantitative and Multivariate Approaches","resumen":"Multivariate analysis became essential in functional and structural Genomics because of the large quantity of biological data provided by these new research areas. Diallel mating design was widely applied to analyze the heritability of quantitative traits but it was recently used for approaching to the inheritance patterns of other levels of gene expression such as transcript profiles. Investigating the inheritance pattern of total polypeptide profiles with a diallel design remains as a vacancy subject. The objective of the present research was to infer the inheritance of total polypeptides profiles from tomato pericarp tissue at four different ripening stages in a diallel mating design including five recombinant inbred lines (RILs) and their ten second cycle hybrids (SCH). To achieve this objective, a multivariate analysis was applied to identify eventual inheritance patterns through a data mining approach and then univariate analyses were used to verify these patterns. Mainly dominance and also overdominance, though in a minor percentage, contributed to the gene actions involved in their genetic basis. Multivariate analysis was efficient in identifying inheritance patterns of total polypeptide profiles through a data mining approach, and univariate analyses largely verified the identified gene actions.","palabras_clave":"Solanum lycopersicum|Plant Genetic Resources|Proteomics|Cluster analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38699,"idioma_id":4,"titulo":"Single-step procedure for trace element determination in synovial fluid by dynamic reaction cell-inductively coupled plasma mass spectrometry","resumen":"A fast and single-step procedure for the dissolution of human synovial fluid in formic acid and further determination by dynamic reaction cell-inductively coupled plasma mass spectrometry (DRC-ICPMS) with a high-efficiency sample introduction system was developed. The samples were collected, treated and analyzed in the same screw-capped tubes. In order to overcome the effect of considerable carbon content, the sample introduction, nebulization and ICP operating conditions were carefully optimized. Furthermore, DRC technology with CH4 as reaction gas was used for the elimination of spectral interferences due to polyatomic ions. The effect of the sample matrix was evaluated and mitigated through comparison of direct calibration against aqueous standards, direct calibration in formic acid media and analyte addition calibration. The recommended procedure involved low dilution and low detection limits (from 0.003ìgL-1 for U to 13.3ìgL-1 for Ti) with adequate precision (from 0.6% for Co to 6.6% for Ti). The proposed method was successfully applied to determine 16 trace elements in concentrations from 0.03ìgL-1 (Cd) to 88.2ìgL-1 (Cu) in human synovial fluid samples. © 2013 Elsevier B.V.","palabras_clave":"Trace elements|Human synovial fluid|Formic acid solubilization|High efficiency sample introduction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38700,"idioma_id":4,"titulo":"Bioreduction of (-)-achalensolide using pure strains of penicillium sp. and rhizopus sp.","resumen":"Natural products and related structures are an important source of  compoundswith biological activity. Biotransformations of organicmolecules  provides the ability to obtain new compounds which can be tested. This  technique has the advantage of enabling functionalized organic compounds  using enzymes in microorganisms through simple reactions, in a regio-and  stereoselective way, in mild conditions and avoiding polluting the  environment. In order to look for new active compounds, pure strains of  phytopatogenic fungi Penicillium sp. and Rhizopus sp., were used to  transform the sesquiterpene lactone (-)-achalensolide in a regio and  streoselective way to obtain one reduced metabolite, 11â,13-  dihydroachalensolide. A two stages standard protocol was used and after  isolation and purification of product, IR, 1H and 13C NMR spectroscopy  allowed to confirmits structure. 1,1-diphenyl-2-picrylhydrazyl and Artemia  salina in vitro assays were done to test starting material and product  obtained. They showed weak similar activity when compared to reference  compounds, so structural modification had no effect on it.","palabras_clave":"BIOTRANSFORMATION| ACHALENSOLIDE|REDUCTION|FUNGI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38701,"idioma_id":4,"titulo":"Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor- &#947; and cyclooxygenase-2 in renal epithelial cells.","resumen":"The peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription  factors involved in lipid metabolism and glucose utilization, in cell growth, differentiation and  apoptosis, and in the regulation of pro-inflammatory genes expression such as cyclooxygenase-2 (COX-  2). PPAR&#947; is the main isoform in the renal inner medulla where it is believed to possess  nephroprotective actions. In this kidney zone, COX-2 acts as an osmoprotective gene and its expression  is modulated by changes in interstitial osmolarity. In the present work we evaluated whether  hyperosmolar-induced COX-2 expression is modulated by PPAR&#947; in renal epithelial cells MDCK  subjected to high NaCl medium. The results presented herein show that ligand-activated PPAR&#947;  repressed COX-2 expression. But more important, the present findings show that hyperosmolar  medium decreased PPAR&#947; protein and increases the PPAR&#947; phosphorylated form, which is inactive.  ERK1\/2 and p38 activation precedes PPAR&#947; disappearance and induced-COX-2 expression. Therefore,  the decrease in PPAR&#947; expression is required for hyperosmotic induction of COX-2. We also found that  PGE2, the main product of COX-2 in MDCK cells, induced these changes in PPAR&#947; protein. Our results  may alert on the long term use of thiazolidinediones (TZD) since they could affect renal medullary  function that depends on COX-2 for cellular protection against osmotic stress.","palabras_clave":"Hyperosmolarity|cyclooxygenase-2|peroxisome proliferator-activated receptor gamma|nephroprotection"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38702,"idioma_id":4,"titulo":"Direct and Indirect Air Particle Cytotoxicity in Human Alveolar Epithelial Cells","resumen":"Air particulate matter has been associated with adverse impact on the respiratory system leading to cytotoxic and proinflammatory effects. The biological mechanisms behind these associations may be initiated by inhaled small size particles, particle components (soluble fraction) and\/or mediators released by particle-exposed cells (conditioned media). The effect of Urban Air Particles from Buenos Aires (UAP-BA) and Residual Oil Fly Ash (ROFA) a surrogate of ambient air pollution, their Soluble Fractions (SF) and Conditioned Media (CM) on A549 lung epithelial cells was examined. After 24 h exposure to TP (10 and 100 &#956;g\/ml), SF or CM, several biological parameters were assayed on cultured A549 cells. We tested cell viability by MTT, superoxide anion (O&#8322;(-)) generation by NBT and proinflammatory cytokine (TNF&#945;, IL-6 and IL-8) production by ELISA. UAP-BA particles or its SF (direct effect) did not modify cell viability and generation of O&#8322;(-) for any of the doses tested. On the contrary, UAP-BA CM (indirect effect) reduced cell viability and increased both generation of O&#8322;(-) and IL-8 production. Exposure to ROFA particles, SF or ROFA CM reduced proliferation and O&#8322;(-) but, stimulated IL-8. It is worth to note that UAP-BA and ROFA depicted distinct effects on particle-exposed A549 cells implicating morphochemical dependence. These in vitro findings support the hypothesis that particle-induced lung inflammation and disease may involve lung-derived mediators","palabras_clave":"A549|Conditioned media| Cytotoxicity| Inflammation| Particulate matter| ROS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38704,"idioma_id":4,"titulo":"Transcriptional regulation of 9-cis-epoxycarotenoid dioxygenase (NCED) gene by putrescine  accumulation positively modulates ABA synthesis and drought tolerance in Lotus tenuis plants.","resumen":"Accumulation of putrescine and increased arginine decarboxylase activity (EC 4.1.1.19) levels in response to osmotic stress has been reported but the biological meaning of this increase remains unclear. To get a new insight into these questions, we have studied the response to drought of transgenic Lotus tenuis line expressing the oatADC gene driving by the stress-inducible pRD29A promoter. This line contains high levels of putrescine with no changes in spermidine and spermine content even under water deficit. Our results indicate that the biochemical and morphological response to dehydration correlates with Put level and provide evidences that Put controls the ABA content in response to drought by modulating ABA biosynthesis at the transcriptional level.","palabras_clave":"DROUGHT|POLYAMINES|ABSCISIC ACID|ARGININE DECARBOXYLASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38705,"idioma_id":4,"titulo":"The communities of tomato (Solanum lycopersicum L.) leaf endophytic bacteria, analyzed by 16S-ribosomal RNA gene pyrosequencing","resumen":"Abstract  Endophytic bacterial communities of tomato leaves were analyzed by 16SrRNA  gene pyrosequencing and compared to rhizosphere communities. Leaf  endophytes mainly comprised five phyla, among which Proteobacteria was the  most represented (90%), followed by Actinobacteria (1,5%), Planctomycetes  (1,4%), Verrucomicrobia (1,1%), and Acidobacteria (0,5%). Gammaproteobacteria  was the most abundant class of Proteobacteria (84%), while Alphaproteobacteria  and Betaproteobacteria represented 12% and 4% of this phylum,  respectively. Rarefaction curves for endophytic bacteria saturated at 80 OTUs,  indicating a lower diversity as compared to rhizosphere samples (> 1700  OTUs). Hierarchical clustering also revealed that leaf endophytic communities  strongly differed from rhizospheric ones. Some OTUs assigned to Bacillus,  Stenotrophomonas, and Acinetobacter, as well as some unclassified Enterobacteriaceae  were specific for the endophytic community, probably representing bacteria  specialized in colonizing this niche. On the other hand, some OTUs  detected in the leaf endophytic community were also present in the rhizosphere,  probably representing soil bacteria that endophytically colonize leaves.  As a whole, this study describes the composition of the endophytic bacterial  communities of tomato leaves, identifying a variety of genera that could exert  multiple effects on growth and health of tomato plants.","palabras_clave":"PLANT ENDOPHYTIC BACTERIA|CULTURE-INDEPENDENT BACTERIAL ANALYSIS|BACTERIAL DIVERSITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38706,"idioma_id":4,"titulo":"Physiological and molecular implications of plant polyamine metabolism during biotic interactions","resumen":"During ontogeny, plants interact with a wide variety of microorganisms. The association with mutualistic microbes results in benefits for the plant. By contrast, pathogens may cause a remarkable impairment of plant growth and development. Both types of interactions provoke notable changes in the polyamine metabolism of the host and\/or the microbe, being each interaction a complex and dynamic process. Regarding this, it has been well documented that the levels of polyamines, mainly putrescine, spermidine, and spermine, and their conjugated forms suffer profound changes in plant tissues interacting with microorganisms. In general, this is correlated with the induction of biosynthetic as well as catabolic enzymes. Interestingly, some evidences suggest that the relative importance of these metabolic pathways may depend on the nature of the microorganism. This concept stems from the fact that these amines, in particular spermine, mediate the activation of plant defense mechanisms. This effect is not only exerted by the polyamine itself, but its catabolism has been likewise demonstrated to make a remarkable contribution to defense. Thus, apoplastic H2O2 generated by the activity of polyamine oxidases induces defense gene expression and elicits plant cell death during the hypersensitive response. In this trend, it was shown that polyamine oxidation favors the infections originated by necrotrophic microorganisms, which fed from dead matter, but protect plants from biotrophic pathogens colonizing living plant tissues. In turn, a precise coordination of general polyamine metabolism would also be required to allow mutualistic interactions to occur. In the last years, a great deal of effort has been devoted to profile plant gene expression in response to invading microorganisms. In addition, the phenotypes of transgenic and mutant plants in polyamine metabolic genes have been assessed. In this review, we integrated the current knowledge on this field and analyze the possible roles of these amines during the interaction of plants with microbes.","palabras_clave":"POLYAMINES|POLYAMINE METABOLISM|BIOTIC INTERACTIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38707,"idioma_id":4,"titulo":"Kaolinitic calcined clays - Portland cement system:  Hydration and properties","resumen":"This paper examines the influence of type of kaolinite in the raw clay on the performance of calcined clays as supplementary cementing materials. two kaolinitic clays were characterized, calcined then ground and uses as partial replacement of portland cement at 15% and 30% by mass.The results show that both kaolinitic calcined clays are an effctive pozzolan with different reaction rate. the reactivity is related to the specific surface area obtained after calcination and it depends on the structure of kaolinite.raw clay containg disordered structure presents a very high pozzolanic activity allowing high replacement levels (30%) in blended cements.","palabras_clave":"calcined clay|kaolinita|blended cement"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38708,"idioma_id":4,"titulo":"Thermal analysis to assess pozzolanic activity of calcined kaolinitic clays","resumen":"Abstract The use of calcined clays as partial replacement of cement is encouraged since it promotes the reduction of the green-house gas emission and the energy requirementof cement-based material, maintaining or enhancing the mechanical properties and the durable performance of these materials. In this paper, the use of thermal methods? DTA\/TG and calorimetry?to select and to evaluate two kaolinitic clays for their use as pozzolanic materials wasexplored. The content and crystallinity of kaolinite in clays can be determined by DTA\/TG analysis, and this technique is also suitable to select the calcination temperature for complete kaolinite dehydroxylation. Calorimetric analysis on blended cements (30 % by mass of replacement) can differentiate the reactivity of calcined kaolinitic clays.Results show that more reactive calcined kaolinitic clay develops the second and third peaks earlier than those of PC with great intensity and high acceleration. The reactivity of calcined clays is associated to raw materials containing kaolinite with high structural disorder that determines calcined clays with large specific surface area, high grindability, and small mean particles size (d50) for the same grinding objective. Finally, the DTA\/TG analysis can determine the type and the amount of hydrated phases obtained at different ages to evaluate the pozzolanic reactionof calcined clay in accordance with the standardized pozzolanic activity index.","palabras_clave":"kaolinita|calcined clay|pozzolanic activity|cement"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38709,"idioma_id":4,"titulo":"Epstein-Barr Virus Down-Regulates Tumor Suppressor DOK1 Expression","resumen":"The DOK1 tumor suppressor gene encodes an adapter protein that acts as a negative regulator of several signaling pathways. We have previously reported that DOK1 expression is up-regulated upon cellular stress, via the transcription factor E2F1, and down-regulated in a variety of human malignancies due to aberrant hypermethylation of its promoter. Here we show that Epstein Barr virus (EBV) infection of primary human B-cells leads to the down-regulation of DOK1 gene expression via the viral oncoprotein LMP1. LMP1 alone induces recruitment to the DOK1 promoter of at least two independent inhibitory complexes, one containing E2F1\/pRB\/DNMT1 and another containing at least EZH2. These events result in tri-methylation of histone H3 at lysine 27 (H3K27me3) of the DOK1 promoter and gene expression silencing. We also present evidence that the presence of additional EBV proteins leads to further repression of DOK1 expression with an additional mechanism. Indeed, EBV infection of B-cells induces DNA methylation at the DOK1 promoter region including the E2F1 responsive elements that, in turn, lose the ability to interact with E2F complexes. Treatment of EBV-infected B-cell-lines with the methyl-transferase inhibitor 5-aza-2&#8242;-deoxycytidine rescues DOK1 expression. In summary, our data show the deregulation of DOK1 gene expression by EBV and provide novel insights into the regulation of the DOK1 tumor suppressor in viral-related carcinogenesis.","palabras_clave":"DOK1 tumor suppressor|EBV|cellular transformation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38710,"idioma_id":5,"titulo":"¿Existen asociaciones entre sociabilidad, aprendizaje y comunicación entre perros y personas?","resumen":"Los perros mantienen un estrecho vínculo con las personas y algunos rasgos como la sociabilidad y la velocidad de aprendizaje podrían modular la comunicación entre ambas especies. El objetivo de este trabajo fue indagar la existencia de asociaciones entre los niveles de sociabilidad, la mirada espontanea a la cara humana para pedir comida inaccesible como respuesta comunicativa y el aprendizaje de inhibir una conducta no social (acercarse a una fuente de comida) para desplegar una respuesta social (acudir al llamado de una persona desconocida). Para ello previamente nos propusimos validar la prueba utilizada para medir sociabilidad evaluando la estabilidad del rasgo de sociabilidad a través de una evaluación-reevaluación de los sujetos. Los resultados sugieren una consistencia en la sociabilidad a través del tiempo. A su vez se hallaron asociaciones entre la sociabilidad y la mirada como respuesta comunicativa pero no con el aprendizaje de inhibición. Tanto la sociabilidad como la respuesta de mirada son fundamentales para el desarrollo de diversas clases de entrenamiento.","palabras_clave":"SOCIABILIDAD|MIRADA|COMUNICACIÓN|PERROS DOMÉSTICOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38711,"idioma_id":5,"titulo":"¿Pueden los perros domésticos (Canis lupus familiaris) reconocer expresiones emocionales humanas? Una revisión crítica de las evidencias","resumen":"Las expresiones emocionales tienen un papel fundamental en las interacciones de especies sociales, brindando información acerca del emisor, las características e importancia del estímulo o situación que desencadena dichas interacciones, y también funcionan regulando los vínculos sociales. Los perros poseen notorias capacidades comunicativas hacia los humanos por lo que resulta interesante estudiar si estas habilidades se extienden al reconocimiento de las expresiones emocionales. Se han realizado diversas investigaciones acerca del reconocimiento de expresiones emocionales humanas en perros exponiendo a los mismos a una situación representada por personas durante la evaluación, así como mediante el uso de imágenes, videos y grabaciones. El análisis de las evidencias permite concluir que los perros podrían distinguir entre distintas emociones humanas ya sea en presencia de modelos en vivo o mediante la observación de imágenes y modulan su conducta conforme a esta discriminación, así como también pueden utilizar esta información como claves en la resolución de problemas. Sin embargo, aún no están claros los mecanismos que subyacen a estas habilidades.","palabras_clave":"EXPRESIONES EMOCIONALES|CLAVES VISUALES|CLAVES VERBALES|RELACION PERRO-HUMANO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38713,"idioma_id":4,"titulo":"Upgrading of diols by gas-phase dehydrogenation and dehydration reactions on bifunctional Cu-based oxides","resumen":"Biomass-derived short chain polyols can be transformed in valuable oxygenates used as building blocks. The gas phase conversion of a model molecule of 1,3-diols (1,3-butanediol) was studied on bifunctional Cu-Mg, Cu-Al and Cu-Mg-Al mixed oxide catalysts that combine surface Cu0 particles and acid-base properties. A series of ZCuMgAl catalysts (Z=0.3-61.2 wt.% Cu, Mg\/Al=1.5 molar ratio) was prepared by coprecipitation and thoroughly characterized by several techniques such as BET surface area, TPR-N2O chemisorption, XRD and TPD of CO2. The ZCuMgAl catalysts promote the upgrading of the diol by a series of dehydrogenation and\/or dehydration reactions proceeding at reaction rates that depend on the copper content (Z). The overall activity increases linearly with the amount of surface Cu0 species thereby confirming participation of metallic sites in rate-limiting steps. Besides, surface Cu0 sites favor the reaction pathway toward 1,3-butanediol dehydrogenation. Thus, the dehydrogenation\/dehydration selectivity ratio increases with Z as a result of the enhanced amount of exposed Cu0 particles. ZCuMgAl catalysts with Z  8wt.% are more active and yield valuable multifunctional C4 oxygenates such as hydroxyketones and to a lesser extent, unsaturated alcohols and ketones. A strongly basic Cu-Mg catalyst promotes the C-C bond cleavage reaction giving short carbon chain oxygenates at low rates; an acidic Cu-Al catalyst converts the diol into the C4 saturated ketone and olefins.","palabras_clave":"DIOL VALORIZATION|DEHYDRATION|DEHYDROGENATION|BIFUNCTIONAL Cu-BASED OXIDES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38714,"idioma_id":4,"titulo":"Effect of limited enzymatic hydrolysis on linoleic acid binding properties of -Lactoglobulin","resumen":"Beta-Lactoglobulin (BLG) is a member of lipocalin family, proteins with ability to bind small hydrophobic ligands, such as retinol, vitamins and fatty acids. Moreover, BLG is susceptible to protease action producing a wide range of polypeptides depending on the hydrolysis degree (HD). In the present work, the effect of limited enzymatic hydrolysis on fatty acid binding properties of BLG was studied. Linoleic acid (LA) was used as a model fatty acid. Limited enzymatic hydrolysis was performed using alpha-chymotrypsin immobilized on agarose microparticles. BLG hydrolysates were produced at HD: 1, 3 and 5%. In order to determine the influence of HD on BLG molecular weight SDS-PAGE was used. BLG structural modification and LA binding properties were monitored by means of fluorescence spectroscopic techniques. The increase in HD produced: (i) a BLG degradation and a molecular weight distribution of BLG hydrolysates and (ii) an increased exposition of buried hydrophobic residues, however it was observed a decrease in surface hydrophobicity possibly due to a deterioration of hydrophobic protein domains. It was observed that enzymatic hydrolysis treatment produced a decrease in BLG ability for binding LA. It was concluded that limited enzymatic hydrolysis could deteriorate the specific site on BLG structure necessary for binding LA.","palabras_clave":"BETA-LACTOGLOBULIN|LINOLEIC ACID|ENZYMATIC HYDROLYSIS |NANOENCAPSULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38715,"idioma_id":4,"titulo":"Beta-lactoglobulin heat-induced aggregates as carriers of polyunsaturated fatty acids","resumen":"The aim of this work was to obtain heat-induced beta-lactoglobulin (BLG) aggregates in order to test them as carriers of a model polyunsaturated fatty acid (PUFA), linoleic acid (LA). BLG aggregates were obtained at 85ºC varying the heating time (0-60 min) and the pH of protein dispersion (6.5-7.5). Aggregates were characterized by intrinsic and extrinsic fluorescence and surface hydrophobicity (S0). Binding experiments were conducted by fluorescence spectroscopy. Results showed an increased BLG aggregate S0 values which could strongly depend on the pH of aggregate formation. Aggregates obtained at pH 6.5 showed the greatest S0 values so they could be applied as LA carriers. Nevertheless, conjugation of LA to BLG aggregates showed a complex behaviour depending on the aggregate producing conditions (pH, heating time and\/or combination). LA binding properties of BLG aggregates were not linked with their hydrophobic characteristics suggesting that conjugation could require the structural preservation of LA binding site.","palabras_clave":"BETA-LACTOGLOBULIN|PUFAS|LIGAND BINDING PROPERTIES|PROTEIN CARRIERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38716,"idioma_id":4,"titulo":"Sol Gel Derived Fe Rich Matrix Composites Having Precipitated WC","resumen":"Composites of tungsten carbide embedded in an iron matrix were produced through a sol gel chemical route based on metal alkoxides. The sol gel masses were heat treated with different time-temperature cycles to study phase formation and phase evolution in the W-C-Fe system.&nbsp; Heat treatments included a &nbsp;heating step up to 600-800°C under a flow of 10%H2-Ar followed by a heating step at vacuum conditions up to 1360°C for 2h. Sol-gel masses having weight ratios W\/Fe=1.5 and extra colloidal carbon were successfully densified. As a result Fe-rich matrix composites having stoichiometric WC reinforcing phase were formed. X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy using Electron Dispersive Spectroscopy confirmed the precipitation and growth of elementary nearly single crystal faceted WC grains, although having an important amount of dislocations and\/or inner faults. Addition of colloidal alumina nanoparticles decreased significantly the densification of the W-C-Fe compositions, mainly by arresting polycrystalline WC grain growth. Furthermore the conversion of the above amorphous masses under 10%H2-Ar into mixtures of WC and Fe-alloys at temperatures around 800-900°C was analyzed from dilatometric data in order to assess the effect of composition and heating conditions on the formation and grain growth of WC grains. &nbsp;      st1:*{behavior:url(#ieooui) }  ","palabras_clave":"WC-Fe composites|sol-gel method|WC formation|solid state sintering"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38717,"idioma_id":4,"titulo":"Solanesyl Diphosphate Synthase, an Enzyme of the Ubiquinone Synthetic Pathway, Is \tRequired throughout the Life Cycle of Trypanosoma brucei","resumen":"Ubiquinone 9 (UQ9), the expected product of the long-chain solanesyl diphosphate synthase of Trypanosoma brucei (TbSPPS),  has a central role in reoxidation of reducing equivalents in the mitochondrion of T. brucei. The ablation of TbSPPS gene expression  by RNA interference increased the generation of reactive oxygen species and reduced cell growth and oxygen consumption.  The addition of glycerol to the culture medium exacerbated the phenotype by blocking its endogenous generation and excretion.  The participation of TbSPPS in UQ synthesis was further confirmed by growth rescue using UQ with 10 isoprenyl subunits  (UQ10). Furthermore, the survival of infected mice was prolonged upon the downregulation of TbSPPS and\/or the addition of  glycerol to drinking water. TbSPPS is inhibited by 1-[(n-oct-1-ylamino)ethyl] 1,1-bisphosphonic acid, and treatment with this  compound was lethal for the cells. The findings that both UQ9 and ATP pools were severely depleted by the drug and that exogenous  UQ10 was able to fully rescue growth of the inhibited parasites strongly suggest that TbSPPS and UQ synthesis are the  main targets of the drug. These two strategies highlight the importance of TbSPPS for T. brucei, justifying further efforts to validate  it as a new drug target","palabras_clave":"Solanesyl diphosphate synthase|Trypanosoma brucei|Ubiquinone 9|Bisphosphonates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38718,"idioma_id":4,"titulo":"Insecticidal effects of the annonaceous acetogenin squamocin and the acetogenin fraction of seeds of Rollinia occidentalis on soybean and corn pests","resumen":"A treatment based on the acetogenin fraction of the methanol extract of Rollinia occidentalis seeds was applied to soybean crops for three consecutive years. In relation to the control population, the treatment reduced the population of Anticarsia gemmatalis, Rachiplusia nu, Pseudoplusia includens, Loxostege bifidalis and Spodoptera frugiperda to 52% and 65% after 48 h of application at concentrations of 500 and 750 µg\/mL respectively, while low toxic effects were detected on natural enemies. The extract treatment at 500 µg\/mL and a solution of the annonaceous acetogenin,squamocin, at 50 and 100 µg\/mL, were also applied to a corn field to produce 75%, 93% and 100% mortality rates on the population of S. frugiperda, respectively, after 72 h of application. In addition, damages caused by lepidopterans in treated crops were lower than those observed innon treated fields, evaluated by residual biomass. This statement is based on data from trials with the commercially available insecticides lufenuron and cypermethrin.","palabras_clave":"Annonaceous Acetogenins| Polyphagous Lepidopteran|Soybean Crops|Corn Crops"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38719,"idioma_id":4,"titulo":"Effective properties of nodular cast-iron: A multi-scale computational approach","resumen":"A numerical approach based on a computational constitutive multi-scale   model is used in this work to predict the effective Young?s modulus and   Poisson?s ratio of a pearlitic nodular cast iron. The Representative   Volume Element (RVE) is defined based on a set of micrographs acquired   from an optical device. For each micrograph, two RVE with different   shape, rectangular and hexagonal, are defined. The volume fraction of   graphite and metal matrix and the boundary of each object were   identified on each RVE by using a procedure of image enhanced and   segmentation. The set of RVE obtained was meshed with triangular finite   elements. The numerical results obtained with rectangular and hexagonal   RVE are compared with results obtained by means of an analytical   expression. The influence of graphite fractions, aspect ratios and   nodularity are investigated. The results show that graphite fraction has   the largest influence on the effective modulus E. This feature   is independent of the external shape of the RVE. Only one multi-scale   model show a good agreement with the analytical expression in the   effective modulus E. Also, the influence of the graphite volume   fraction on the effective Poisson?s ratio is investigated by means of   multi-scale simulation.","palabras_clave":"FINITE ELEMENT|MATERIAL CHARACTERIZATION|MULTI-SCALE MODELING|NODULAR CAST IRON|REPRESENTATIVE VOLUME ELEMENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38720,"idioma_id":4,"titulo":"mRNA of cytokines in bone marrow and bone biomarkers in response to propranolol in a nutritional growth retardation model","resumen":"Background: The aim of this study was to assess mRNA of IL-6, TNFa and IL-10 cytokines in bone marrow,  possible mediators involved in altered bone remodeling with detrimental consequences on bone quality  in NGR (Nutritional growth retardation) rats.  Methods: Weanling male Wistar rats were assigned either to control (C) or experimental group (NGR)  (n = 20 each). C and NGR groups were assigned to 2 groups according to receiving saline solution (SS) or  propranolol hydrochloride (P): C, C + P (CP), NGR or NGR + P (NGRP). For 4 weeks, NGR and NGRP rats  received 80% of the amount of food consumed by C and CP, respectively, the previous day, corrected by  body weight. P (7 mg\/kg\/day) was injected ip 5 days\/week, for 4 weeks in CP and NGRP rats. Body weight  and length were recorded. After 4 weeks, blood was drawn. Femurs were dissected for RNA isolation  from bone marrow and mRNA of cytokines assays.  Results: Food restriction induced a significant negative effect on body growth in NGR and NGRP rats  (p  0.05). CTX-I increased in NGR rats vs. C  (p  0.05). In NGR, bone marrow IL-6 mRNA and IL-10 mRNA  levels were low as compared to other groups (p < 0.05). In contrast, bone marrow TNF-a mRNA levels  were significantly high (p < 0.05).  Conclusions: This study provides evidences that NGR outcomes in a bone marrow proinflammatory  microenvironment leading to unbalanced bone remodeling by enhancement of bone resorption reverted  by propranolol","palabras_clave":"Nutritional growth retardation| Cytokines |Bone turnover| Propranolol"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38721,"idioma_id":4,"titulo":"Carbon and nitrogen sequestration in soils under different management in the semi-arid pampa (Argentina)","resumen":"Soil management affects distribution and the stocks of soil organic carbon and total nitrogen. The aim of this study was to evaluate the effect of different crop sequences and tillage systems on the vertical distribution and stocks of soil carbon and nitrogen. We hypothesized that no-tillage promotes surface organic carbon and total nitrogen accumulation, but does not affect the C and N stocks, when compared with reduced tillage. In addition, the incorporation of maize in the crop sequence increases total organic carbon and total nitrogen stocks. Observations were carried out in 2010 in an experiment located in the semiarid Argentine Pampa, on an Entic Haplustoll. A combination of three tillage systems (no tillage, no tillage with cover crop in winter and reduced tillage) and two crop sequences (soybean?maize and soybean monoculture) were assessed. After 15 years of management treatments, soil samples to a depth of 100 cm at seven intervals, were taken and analyzed for bulk density, organic carbon and total nitrogen. Total organic carbon stock up to a depth of 100 cm showed significant differences between soils under different tillage systems (reduced tillage < no tillage = no tillage with cover crop), the last ones having 8% more than the reduced tillage treatment. Soybean?maize had 3% more organic C up to 100 cm depth than the soybean monoculture. Total nitrogen stock was higher under no-till treatments than under reduced tillage, both at 0?50 and 0?100 cm depths. Total organic carbon stratification ratios (0?5 cm\/5?10 cm) were around 1.6 under no-till and lower under reduced tillage. The stratification ratio explains less than 40% of soil carbon stock. Tillage system had a greater impact on soil carbon stock than crop sequence.","palabras_clave":"carbon and nitrogen stocks|no till|reduced tillage|maize|soybean|cover crop"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38722,"idioma_id":4,"titulo":"Revisiting the 7Li(p,n)7Be reaction near threshold","resumen":"In this work we review all the available experimental neutron data for the 7Li(p,n) reaction near threshold which is necessary to obtain an accurate source model for Monte Carlo simulations in Boron Neutron Capture Therapy. Scattered published experimental results such as cross sections, differential neutron yields and total yields were collected and analyzed,exploring the sensitivity of the fitting parameters to the different possible variables and deriving a consistent working set of parameters to evaluate the neutron source near threshold.","palabras_clave":"7Li(p,n)7Be REACTION NEAR THRESHOLD|DIFFERENTIAL NEUTRON YIELD|(p,n) CROSS SECTION|CM PARAMETRIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38723,"idioma_id":4,"titulo":"(9)Be(d,n)(10)B-based neutron sources for BNCT","resumen":"In the frame of accelerator-based BNCT,the 9Be(d,n)10B reaction was investigated as a possible source of epithermal neutrons.In order to determine the configuration in terms of bombarding energy,targetthickness and Beam Shaping Assembly (BSA )design that results in the best possible beam quality, a systematic optimization study was carried out. From this study, the optimal configuration resulted in tumor doses of no less than 40 Gy-Eq, with a maximum value of 51Gy-Eq at a depth of about 2.7cm, in a 60min treatment.The optimal configuration was considered for the treatment planning assessment of a realGlioblastoma Multiforme case. From this,the resulted dose performances were comparable to those obtained with an optimized 7Li(p,n)-based neutron source,under identical conditions and subjected to the same clinical protocol.","palabras_clave":"(9)Be(d,n)(10)B reaction|Accelerator-based BNCT|Brain tumor treatment|Monte-Carlo simulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38724,"idioma_id":4,"titulo":"The influence of re-flooding on phytoplankton assemblage attributes in a temperate wetland following a severe drought period","resumen":"Wetlands can experience drying and flooding cycles which influence the dynamics of the phytoplankton assemblages. The aim of ourstudy was to evaluate changes in the phytoplankton structure during a drought\/flood period in a warm-temperate wetland. We hypothesizedthat fluctuations in water level and development of macrophytes favour the development of fast-growing algae with adaptations to lowlight conditions. We studied algal and cyanobacterial colonization and succession in the nascent planktonic habitat in a wetland in theSouthern Hemisphere (Argentina). We assessed changes in phytoplankton biovolume, chlorophyll aconcentration (Chl a), richness, diversity,and evenness throughout a drought\/flood period. Phytoplankton species were classified into ecological functional groups (FG). Multivariateanalysis (RDA) showed that water level, conductivity and percentage macrophyte cover of the site surface (PCSS) explained the variabilityin the phytoplankton assemblage structure in terms of classes and FG. Particularly, FGs T and LMresponded to the changes during thedrought\/flood cycle, probably due to light constraints and stability of the water column induced by the development of emergent and free-floating macrophytes. Our study expands the knowledge of phytoplankton species composition and ecological FG succession under free-floating macrophyte cover in a re-flooding episode. We conclude that water depth and development of macrophytes are the key factors inshaping phytoplankton species structure in a temporary wetland.","palabras_clave":"Phytoplankton|Wetland|Shallow lake|Drought|Flood|Biodiversity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38725,"idioma_id":4,"titulo":"Effects of Glyphosate on Growth Rate, Metabolic Rate and Energy Reserves of Early Juvenile Crayfish, Cherax quadricarinatus M.","resumen":"Early juveniles of the crayfish Cherax quadricarinatus were exposed for 60 d to 10 and 40 mg\/L of pure glyphosate (acid form) in freshwater. Mortality was 33% at the highest concentration, while no differences in molting were noted among treatments. After the first month of exposure, weight gain was significantly (p&lt;0.05) reduced in the 40 mg\/L group. At the end of the assay, lipid levels in muscle, as well as protein level in both hepatopancreas and muscle were significantly (p&lt;0.05) reduced.&nbsp; These results suggest long-term utilization of both lipid and protein as main energetic reserves, likely in response to the chronic stress associated with herbicide exposure. Besides, the lower pyruvate kinase activity in muscle suggests a possible metabolic depression in this tissue. The hemolymphatic ASAT:ALAT ratio showed higher levels than the control at the highest glyphosate concentration, indicating possible damage to several tissues.","palabras_clave":"CRAYFISH|SOMATIC GROWTH|GLYPHOSATE|METABOLISM|ENZYMES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38726,"idioma_id":4,"titulo":"On the Electrochemical Deposition and Dissolution of Divalent Metal Ions","resumen":"The deposition of Cu2+ and Zn2+ from aqueous solution has been investigated by a combination of classical molecular dynamics, density functional theory, and a theory developed by the authors. For both cases, the reaction proceeds through two one-electron steps. The monovalent ions can get close to the electrode surface without losing hydration energy, while the divalent ions, which have a stronger solvation sheath, cannot. The 4s orbital of Cu interacts strongly with the sp band and more weakly with the d band of the copper surface, while the Zn 4s orbital couples only to the sp band of Zn. At the equilibrium potential for the overall reaction, the energy of the intermediate Cu+ ion is only a little higher than that of the divalent ion, so that the first electron transfer can occur in an outer-sphere mode. In contrast, the energy of the Zn + ion lies too high for a simple outer-sphere reaction to be favorable; in accord with experimental data this suggests that this step is affected by anions.","palabras_clave":"ELECTROCHEMICAL DEPOSITION|DISSOLUTION|DIVALENT METAL IONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38727,"idioma_id":4,"titulo":"Electrochemical Adsorption of OH on Pt(111) in Alkaline Solutions: Combining DFT and Molecular Dynamics","resumen":"The adsorption of OH on Pt(111) in alkaline solution has been investigated by a method that combines density functional theory, molecular dynamics, and quantum statistical mechanics. In particular, we have calculated the free energy surface for the reaction. A physisorbed hydroxide ion in a metastable state and a stable adsorbed uncharged OH group are observed. The energy of activation at equilibrium is comparatively low, so that the reaction is fast.","palabras_clave":"ELECTROCHEMICAL ADSORPTION|OH|DFT|MOLECULAR DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38728,"idioma_id":4,"titulo":"Screening of ions in carbon and gold nanotubes - A theoretical study","resumen":"We examine the insertion of alkali ions into narrow nanotubes of graphite and gold by density functional theory. The surrounding tubes screen the ionic charge very effectively; the resulting image energy compensates well for the loss of solvation. In addition, ion-ion interactions are strongly reduced. These effects are stronger for gold than for graphite tubes. Our results explain at an atomic level, why narrow tubes store charge so effectively.","palabras_clave":"NANOTUBES|CHARGE STORAGE|SCREENING|IMAGE CHARGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38729,"idioma_id":4,"titulo":"Encrypted CDMA audio network","resumen":"We present a secure LAN using sound as the physical layer for low speed applications. In particular, we show a real implementation of a point-to-point or point-to-multipoint secure acoustic network, having a short range, consuming a negligible amount of power, and requiring no specific hardware on mobile clients. The present acoustic network provides VPN-like private channels to multiple users sharing the same medium. It is based on Time-hopping CDMA, and makes use of an encrypted Bloom filter. An asymmetrical error-correction is used to supply data integrity, even in the presence of strong interference. Simulations and real experiments show its feasibility. We also provide some theoretical analysis on the principle of operation.","palabras_clave":"Non-Audible Communication|Ad-Hoc Network|Security"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38730,"idioma_id":4,"titulo":"Interpopulation differences in parasite load and variable selective pressures on MHC genes in the subterranean rodent Ctenomys talarum (Rodentia: Ctenomyidae)","resumen":"We explore potential geographic variation in the pathogen-mediated selective pressures acting on Major Histocompatibility Complex (MHC) loci in the subterranean rodent Ctenomys talarum, evaluating the impact of differences in parasite load between 2 populations (Mar de Cobo [MdC] and Necochea [NC]) on immunogenetic variation and selection on MHC genes in this species. Because Ctenomys from NC face lower parasite load and presumably weaker pathogen-mediated selection on MHC, we expected to find a weaker correlation between MHC variation and parasite load and\/or immunocompetence in this population compared to that at MdC. MHC-associated cues are used in other species of rodents as kinship markers to avoid inbreeding, and because kinship structure is less pronounced in NC, we predicted that use of MHC-associated cues in mate choice would be less apparent in this population. We characterized MHC variation in NC as a function of parasite load and immunocompetence and compared our results with previous findings for MdC. The 2 populations were sampled across different, but consecutive, years. Using co-inertia analyses, we found a significant positive association between a specific DRB allele and intensity of infection by fleas in NC. We explored the use of MHC-associated cues in mate choice in NC and found support for both the ?good genes? and the ?genetic compatibility? hypotheses.  As expected, associations between MHC and parasite load or immunocompetence were weaker in NC. Evidence indicated that females in NC selected for males with lower MHC diversity. This suggests that parasite-driven selection acting directly on MHC genes seems to be greater for the population facing higher parasite load. However, parasite-driven selection mediated by mate choice may not only be influenced by levels of parasite diversity in the population but also by characteristics of the mating system.","palabras_clave":"IMMUNOCOMPETENCE|MATE CHOICE|MHC|PARASITE LOAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38731,"idioma_id":4,"titulo":"Heme oxygenase-independent endogenous production of carbon monoxide by soybean plants subjected to salt stress","resumen":"Exogenous application of CO is a  valuable strategy to study its effects under different stress conditions;  however, in this experimental model a real endogenous CO production by plants  can not be measured. In this work, in order to achieve high sensitivity and to  avoid invasive techniques, we quantify endogenous CO production by tissues in  salt-treated soybean plants through gas chromatography coupled to a reduction  gas detector. This technique allows short and room temperature incubation of  intact tissues and homogenates. We found that a 200mM NaCl treatment induces  total CO production in leaves and roots. Moreover, the sensitivity of the  technique allows to see no correlation between this increment and heme  oxygenase activity, measured as a function of CO production. We also found that  untreated soybean plants produce still signicant CO levels until 7 days post  sowing, and then CO content decreases to a third to remain constant in the next  days. However, HO activity does not change throughout these days. Data here  reported show that HO activity is not the main source of CO in soybean plants.  We discuss alternative sources that could be implicated in this production.  ","palabras_clave":"HEMEOXYGENASE|CARBON MONOXIDE|SOYBEAN|SALT STRESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38732,"idioma_id":4,"titulo":"Acute toxicity of chlorpyrifos to the non-target organism Cnesterodon decemmaculatus","resumen":"Chlorpyrifos is the most used insecticide in Argentina. Cnesterodon decemmaculatus is a widely distributed, endemic fish from Neotropical America. It attains high densities in the shallow water assemblages of Argentina and Brazil. The aim of this study was to assess the acute toxicity of chlorpyrifos to C. decemmaculatus. The mean 96-h LC50 of three independent determinations was 105.3 (±3.1) µg\/L. Sublethal effects were observed. Swimming behavioral changes at each chlorpyrifos expositions were reported. C. decemmaculatus represents a good model for ecotoxicological risk assessment.","palabras_clave":"Clorpirifos|acute toxicity|Cnesterodon decemmaculatus"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38733,"idioma_id":5,"titulo":"CARACTERÍSTICAS FISICOQUÍMICAS DE HARINAS FORTIFICADAS Y HARINA DESTINADAS A LA POBLACION CELÍACA. RELEVAMIENTO DEL CUMPLIMIENTO DE LA LEGISLACIÓN VIGENTE.","resumen":"Los cereales constituyen desde hace siglos la piedra basal de las prácticas agrícolas y por lo tanto de la producción primaria de alimentos. Se ha estudiado que éstos satisfacen actualmente más del 50% de las necesidades de la población mundial, proporcionando hidratos de carbono, proteínas y en menor grado vitaminas, minerales, fibra y algo de lípidos.(1)  Debido al importante rol que cumplen estos cereales como alimento de alto contenido nutricional, es que se planteó como objetivo realizar un relevamiento de las características físico químicas de harinas trigo de marcas comerciales ofrecidas en el mercado, para poder realizar una evaluación comparativa con harinas destinadas a la población celíaca. De esta forma se corroboró el cumplimiento de la legislación, tanto lo exigido por el Código Alimentario Argentino (CAA) en cuanto a sus características fisicoquímicas y los criterios de clasificación; como por la ley 25.630, la cual garantiza la concentración de enriquecimiento en hierro exigida. También se evaluó si las harinas libres de gluten son comparables desde el punto de vista nutricional, con las harinas de trigo.   Se analizaron 340 muestras, de las cuales 107 fueron harinas de trigo, 60 harinas de mandioca, 91 harinas de arroz y 82 premezclas (libres de gluten) para elaborar pan. Las determinaciones físico químicas realizadas fueron, contenido de humedad, cenizas, proteínas, materia grasa, fibra bruta y hierro.  Según los resultados obtenidos podemos decir que tanto las harinas de trigo como las harinas de mandioca cumplieron con los límites exigidos según la legislación, salvo la harina de arroz cuyo cumplimiento fue parcial.  Las premezclas para elaborar panificados aptos para celiacos son comparables nutricionalmente con las harinas de trigo, analizando parámetros que se consideraron apropiados (materia grasa, proteínas, hidratos de carbono y valor energético). En cuanto a la fortificación con hierro, este es el principal inconveniente que presentan estos productos, ya que los niveles encontrados son considerablemente inferiores a los presentes en harinas de trigo.","palabras_clave":"HARINAS |CELIAQUIA|FORTIFICACION|FISICOQUIMICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38734,"idioma_id":4,"titulo":"Monitoring Vegetation Moisture Using Passive Microwave and Optical Indices in the Dry Chaco Forest, Argentina","resumen":"Information about daily variations of vegetation moisture is of widespread interest to monitor vegetation stress and as a proxy to evapotranspiration. In this context, we evaluated optical and passive microwave remote sensing indices for estimating vegetation moisture content in the Dry Chaco Forest, Argentina. The three optical indices analyzed were the Normalized Difference Vegetation Index (NDVI), the Normalized Difference Water Index (NDWI) and the Normalized Difference Infrared Index (NDII) and, for the microwave region the Frequency Index (FI). All these indices are mainly sensitive to leaf area index (LAI), but NDWI and NDII, and FI are also sensitive to leaf water content (LWC) and Canopy Water Content (CWC) respectively. Using optical and microwave radiative transfer models for the vegetation canopy, we estimated the range of values of LAI, LWC and CWC that can explain both NDWI\/NDII and FI observations. Using a combination of simulations and microwave and optical observations, we proposed a two step approach to estimate leaf and canopy moisture content from NDWI, NDII and FI. We found that the short variation of LWC estimated from NDWI and NDII present a dynamic range of values which is difficult to explain from the biophysical point of view, and it is partially related to atmosphere contamination and canopy radiative transfer model limitations. Furthermore, the observed FI short-term variations (~ 8 days) cannot be explained unless significant CWC variations are assumed. The CWC values estimated from FI present a short-term variations possibly related to vegetation hydric stress.","palabras_clave":"Microwave index|optical indices|vegetation water status."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38735,"idioma_id":4,"titulo":"River Water Level Prediction Using Passive Microwave Signatures?A Case Study: The Bermejo Basin","resumen":"The aim of this work is to investigate the exploitation of radiometric acquisitions from satellite sensors at different microwave frequencies in view of the prediction of river water level. A case study has been identi&#64257;ed in the Bermejo basin, in northern Argentina. This river is seasonally affected by severe &#64258;ooding events in the lower part, mostly due to rains occurring in the upper basin, that produce sediment loadings &#64258;ushing down along the lower basin thus changing the watercourse. While the effectiveness of microwave radiometry at Ka band for &#64258;ood moni- toring is consolidated in the literature, this study also considers X and C bands (provided by the Advanced Microwave Scanning Radiometer (AMSR) series together with the higher frequency) and highlights the better sensitivity to soil conditions of L band data (made recently available, thanks to SMOS) over moderately and densely vegetated areas. This study con&#64257;rms, &#64257;rst, the well-known capability of passive microwave remote sensing instruments to record brightness temperature variations due to rainfall and &#64258;oods occurred near river edges under different seasonal conditions. For this purpose, a multifrequency comparative analysis is conducted. Second, it investigates whether these properties can be exploited for &#64258;ood forecasting: a model which directly links the daily satellite measurements to the river water level has been tested, considering 1- to 7-day forecast horizons. The results show that forecasting models can take advantage of the sensitivity of low frequencies to soil moisture conditions in order to predict &#64258;ood peaks, despite the instrument?s low resolutions.","palabras_clave":"flood|forecasting|hydrology|Microwave radiometers"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38736,"idioma_id":4,"titulo":"Female odors promote the activation of sheltered kissing bug Rhodnius prolixus males and modulate their orientation","resumen":"The existence of a pheromone emitted during copulation has been reportedfor Rhodnius prolixus (Hemiptera: Reduviidae) St°al. Adults possess one pair of metasternal glands (MGs) from which female R. prolixus release volatiles mainly at night. We investigated whether these volatiles emitted by adult R. prolixus can modulate sexual-related behaviours of opposite and\/or same sex individuals. We first used a shelter bioassay to test if adult activity patterns can be affected by chemical signals emitted by opposite sex conspecifics. We observed that males left the shelter more frequently in the presence of females, showing higher activity and an increase of intrasexual copulation attempts. Females showed no shelter-related activation in the presence of male odours. Second, we used a locomotion compensator device to investigate whether females or males show oriented responses to odours emitted by adults. We found that males oriented towards air currents carrying female odours butfemales did not orient towards odours emitted by adults. Finally, we observed that males oriented towards the female MG compounds. Thus, a volatile chemical signal emitted by females from their MGs promoted the activation of sheltered males and modulated orientation to air currents.","palabras_clave":"CHEMICAL SIGNALS|LOCOMOTOR ACTIVITY|METASTERNAL GLANDS|SHELTER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38737,"idioma_id":4,"titulo":"Vaccines against bovine babesiosis: where we are now and possible roads ahead","resumen":"Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and\/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems.","palabras_clave":"BOVINE BABESIOSIS|LIVE VACCINES|SUBUNIT VACCINES|TRANSFECTION|ERYTHROCYTE INVASION|TICK-PARASITE INTERACTION|IMMUNE RESPONSE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38738,"idioma_id":4,"titulo":"Genomic comparative analysis of the environmental Enterococcus mundtii against       enterococcal representative species.","resumen":"          Background        Enterococcus  mundtii is a yellow-pigmented microorganism  rarely found in human infections. The draft genome sequence of E. mundtii was recently announced. Its genome encodes at  least 2,589 genes and 57 RNAs, and 4 putative genomic islands have been  detected. The objective of this study was to compare the genetic content of E. mundtii with respect to other enterococcal species and,  more specifically, to identify genes coding for putative virulence traits  present in enterococcal opportunistic pathogens.          Results          An in-depth mining of the  annotated genome was performed in order to uncover the unique properties of  this microorganism, which allowed us to detect a gene encoding the  antimicrobial peptide mundticin among other relevant features. Moreover, in  this study a comparative genomic analysis against commensal and pathogenic  enterococcal species, for which genomic sequences have been released, was  conducted for the first time. Furthermore, our study reveals significant  similarities in gene content between this environmental isolate and the  selected enterococci strains (sharing an ?enterococcal gene core? of 805 CDS),  which contributes to understand the persistence of this genus in different  niches and also improves our knowledge about the genetics of this diverse group  of microorganisms that includes environmental, commensal and opportunistic  pathogens.          Conclusion          Although E.  mundtii CRL1656 is phylogenetically closer to E.  faecium, frequently responsible of nosocomial infections, this strain  does not encode the most relevant relevant virulence factors found in the  enterococcal clinical isolates and bioinformatic predictions indicate that it  possesses the lowest number of putative pathogenic genes amonf the most  representative enterococcal species. Accordingly, infection assays using the Galleria mellonella model confirmed its low virulence  ","palabras_clave":"Enterococcus|Enterococcus mundtii|Genomic comparative analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38739,"idioma_id":4,"titulo":"Influence of process temperature on drying kinetics, physicochemical properties and antioxidant capacity of the olive-waste cake","resumen":"The objective of this study was to determine the effect of drying temperature on the drying kinetics,  20 proximal analysis, energy consumption and the antioxidant capacity of the olive-waste cake ?Picual?  21 variety from 40 to 90 °C. Evaluation of proximal analysis evidenced the influence of temperature on  the waste parameters. Values of effective moisture coefficients were in the range of 1.97-6.05x10-9 22  m2 s-1 under the studied conditions. Activation energy was found to be 28.24 kJ mol-123 . The Weibull  model was successfully applied (r224 >0.973). Specific energy consumption decreased as temperature  25 increased, showing the effect of drying times over temperature. Although dehydrated samples  26 decreased the initial total phenolic content, significant differences were not detected. Effects of  27 drying temperatures did not present significant differences on antioxidant capacity (ORAC and  28 DPPH) when compared to fresh samples. The oleic acid (main fatty acid in fresh samples)  29 presented a maximum increased at 90 °C.","palabras_clave":"OLIVE-WASTE CAKE|PHENOLIC COMPOUNDS|ANTIOXIDANT ACTIVITY|FATTY ACID PROFILE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38740,"idioma_id":4,"titulo":"Application of citric acid and mild heat shock to minimally processed sliced radish: color evaluation","resumen":"The aim of this research was to study the effects of two hurdle technologies, citric acid application (CA) at 0.3, 0.6 and 0.9 % and thermal treatments (IT) for 1, 2 and 3 min at 50 ºC, on the color of radish slices over 10 d of refrigerated storage. Contribution of the hurdles and their interactions were evaluated by examining the treatment effects on the following parameters: chromatic coordinates (L*, a* and b*) and the indices: chroma (&#61508;C*), total color difference (&#61508;E) and Color Index (CI*).   The chromatic parameters for fresh radish (control samples) were L0 = 69.43 ± 0.62, a0 = -0.46 ± 0.05 and b0 = 5.37 ± 0.37, while the calculated color indices were chroma = 5.39 ± 0.36, &#61508;E = 0 and CI* = -1.19 ± 0.17. Regarding control samples, the b* values showed an increasing trend during storage, which was associated with browning of the slices. Both &#61508;E and &#61508;C* values presented similar trends as reported for b*. Based on statistical analysis of the parameters and indices tested, the single hurdle application of low citric acid concentration (0.3 %) or intermediate immersion time (2 min) at 50 ºC minimized the radish slices color changes during storage. However, better results were obtained when two hurdles in series were applied. According to analysis, the treatment T7 (1 min IT, 0.3 % CA) was selected as the best treatment to improve the retention of typical natural color of the minimally processed sliced radishes.","palabras_clave":"MINIMALLY PROCESSED RADISH|CITRIC ACID|MILD HEAT SHOCKS|HURDLE TECHNOLOGIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38741,"idioma_id":4,"titulo":"Principal component and hierarchical cluster analysis to select hurdle technologies for minimal processed radishes","resumen":"The application of principal component and hierarchical cluster analysis as a mathematical tool to select hurdle technologies (physical and chemical) to inhibit polyphenol oxidase (PPO) activity and color stability of minimally sliced radishes was presented. Results of PPO activity and color were reported initially (day zero) and after 4 d of refrigerated storage. Based on the mentioned tools and from the thirteen mono-hurdles technologies that were initially selected, eight hurdles were chosen as the best and combined in pairs. From those hurdles, the following double-hurdles were selected as those capable of retaining the product color: Ascorbic Acid (AA) + Acetic Acid (ACA-05), AA+NaCl-1, ACA-05+NaCl-1, AA + Heat Treatment (TT-501), ACA-05 + Ultrasound (US), Citric Acid (CA) + AA, CA+ACA-05, NaCl-1+US. When comparing the best mono-hurdles (AA, TT-501, NaCl-1) to the best double hurdles, the following hurdles: AA, TT-501, CA+ACA-05, NaCl-1+US, CA+AA and NaCl-1 were chosen as those capable of maintaining the typical color of radish slices with acceptable sensory parameters and enzyme inhibition after 4 d of storage.","palabras_clave":"HURDLE TECHNOLOGY|MINIMALLY PROCESSING|POLYPHENOLOXIDASE|COLOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38742,"idioma_id":4,"titulo":"Killer yeasts as biocontrol agents of spoilage yeasts and bacteria isolated from wine","resumen":"During the winemaking process Saccharomyces cerevisiae is the main yeast species but other yeastscalled non-Saccharomyces as well as different species of lactic acid bacteria (LAB) are also present. Then,one strategy to prevent or reduce microbial contamination during the winemaking process is the use of killeryeasts. The aim of this study was to evaluate the killer activity (KA) of autochthonous yeasts from Northwestregion of Argentine (S. cerevisiae Cf8 and Wickerhamomyces anomalus Cf20) on spoilage yeasts and in LABof the wine. The KA was evaluated using cell-free supernatants obtained from pure and mixed cultures ofstrains Cf8-Cf20. S. cerevisiae Cf8 showed a growth reduction between 7 and 48% on D. anomala BDa15,P. membranifaciens BPm481 and Z. bailii Bzb317 while W. anomalus Cf20 exhibited KA of 20, 61, 91 and92% against B. bruxellensis Ld1, D. anomala BDa15, P. membranifaciens BPm481 and P. guilliermondii Cd6,respectively. Killer mixed supernatants showed growth inhibition similar to strain Cf20. Screening against LABshowed that both killer toxins were able to inhibit the growth of L. hilgardii 5w as well as to reduce a 16?31%histamine production by this LAB strain. These results confirm the potential of autochthonous killer yeasts asbiocontrol agents in winemaking process. The mixed culture S. cerevisiae Cf8-W. anomalus Cf20 presented awide range of KA on spoilage yeasts as well as on L. hilgardii. Therefore, the use of killer yeasts as startercultures would allow producing wines with controlled quality","palabras_clave":"KILLER|YEASTS|BACTERIA|WINE|BIOCONTROL|SPOILAGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38743,"idioma_id":4,"titulo":"Silencing of the tomato Sugar Partitioning Affecting protein (SPA) modifies sink strength through a shift in leaf sugar metabolism","resumen":"Limitations in our understanding about the mechanisms that underlie source-sink assimilate partitioning are increasingly becoming a major hurdle for crop yield enhancement via metabolic engineering. By means of a comprehensive approach, this work reports the functional characterization of a DnaJ chaperone related-protein (named as SPA; sugar partition-affecting) that is involved in assimilate partitioning in tomato plants. SPA protein was found to be targeted to the chloroplast thylakoid membranes. SPA-RNAi tomato plants produced more and heavier fruits compared with controls, thus resulting in a considerable increment in harvest index. The transgenic plants also displayed increased pigment levels and reduced sucrose, glucose and fructose contents in leaves. Detailed metabolic and enzymatic activities analyses showed that sugar phosphate intermediates were increased while the activity of phosphoglucomutase, sugar kinases and invertases was reduced in the photosynthetic organs of the silenced plants. These changes would be anticipated to promote carbon export from foliar tissues. The combined results suggested that the tomato SPA protein plays an important role in plastid metabolism and mediates the source-sink relationships by affecting the rate of carbon translocation to fruits.","palabras_clave":"Tomato|Small plastidial protein|Fruit metabolism|source-sink partitioning"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38744,"idioma_id":4,"titulo":"EASY SYNTHESIS OF NEW SERIES OF PTERIDINE ANALOGS: DI- AND TETRA- HYDROPYRIMIDO[4,5-D]PYRIMIDINES VIA 5-PYRIMIDINE-CARBALDEHYDES","resumen":"Pyrimidine-5-carbaldehyde derivatives, of easy access, were selected as precursors for the  synthesis of mimic pteridine derivatives 5,6-dihydropyrimido[4,5-d]pyrimidines and 5,6,7,8-  tetrahydropyrimido[4,5-d]pyrimidines via 4-amino-(5-aminomethyl)pyrimidine intermediates.  Straightforward procedures allow a quick access to these compounds. The dihydro derivatives  were prepared means of a final cyclocondensation carried out with orthoesters, catalysed by acid  and assisted by microwaves irradiation under solvent free conditions. The final cyclocondensation  with carbonyl compounds forming the tetrahydro derivatives was done under mild  conditions, in which stereochemical induction was carried out on the building of this skeleton,  and stereochemistry assignments corroborated by theoretical calculations.","palabras_clave":"PYRIMIDINECARBALDEHYDES|Molecular Modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38745,"idioma_id":4,"titulo":"Human pegivirus molecular epidemiology in Argentina: potential contribution of Latin American migration to genotype 3 circulation","resumen":"            In order to determine  the human pegivirus (HPgV) genotypic diversity in Argentina taking into account  the potential contribution of human migration from neighboring countries,  samples from 130 Argentine injecting drug users, 116 Argentine- and 50  immigrant-pregnant women were analyzed. HPgV RNA prevalence among human  immunodeficiency virus (HIV)-positive injecting drug users was similar to  HIV-positive pregnant women, as was the case when comparing HIV-negative  injecting drug users and HIV negative pregnant women (P&gt;0.05). HPgV genotype 2 (HPgV\/2) was prevalent among  both Argentine injecting drug users and pregnant women, in contrast to HPgV\/3  observed among pregnant women from Latin American countries with predominant  indigenous populations and who had experienced their initial sexual  intercourses --and possibly their source of infection-- in those countries (P&lt;0.01). In addition,  HPgV vertical and horizontal transmission was proven by molecular analysis of  E2 gene and construction of identity matrixes with epidemiologically non-related  isolates. This study shows that human migration from neighboring Latin American  countries with predominant indigenous populations might contribute to HPgV\/3  circulation in Argentina.                                                              ","palabras_clave":"GBV-C|ARGENTINA|GENOTYPES|IMMIGRANTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38746,"idioma_id":5,"titulo":"Hacia una comunidad de prácticas en alfabetización académica: relato de una experiencia en Ciencias Humanas","resumen":"El propósito de este artículo es relatar una experiencia desarrollada en el marco de un proyecto de democratización del acceso al conocimiento universitario -PRODEC- que implicó la realización de diversas acciones de acompañamiento a equipos que desarrollan prácticas de alfabetización académica en los primeros años de la universidad. En este sentido, la experiencia se inscribe en políticas académicas inclusivas destinadas a alentar la innovación educativa y la articulación de saberes en acción. El proyecto contó con la participación de docentes y estudiantes de diferentes carreras, convocados por el trabajo conjunto entre la cátedra de Pedagogía Universitaria y el Área de Apoyo a la Enseñanza de la Secretaría Académica de la Facultad de Ciencias Humanas (UNRC). Los principios teóricos que orientaron este trabajo se apoyan en investigaciones que muestran el papel central de las prácticas de lectura y escritura en la educación universitaria y del valor del trabajo colaborativo e interdisciplinario para desarrollar y sostener innovaciones en este campo. Desde esta concepción, el propósito central fue colaborar en la creación de una comunidad de prácticas en torno a la lectura y escritura académicas. Las acciones desarrolladas consistieron básicamente en el análisis de las experiencias, el intercambio a través de relatos escritos y un ateneo de formación y debate pedagógico, con aportes de especialistas en el campo. Los resultados muestran interesantes procesos de reflexión crítica, avances en el diseño, fundamentación y seguimiento de las prácticas de alfabetización académica y un incremento en las relaciones de colaboración entre los diversos grupos implicados","palabras_clave":"ALFABETIZACIÓN ACADÉMICA|COMUNIDAD DE PRÁCTICAS|FORMACIÓN PEDAGÓGICA|UNIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38747,"idioma_id":4,"titulo":"Perfluorobutylation of benzo(hetero)arenes in aqueous media","resumen":"Perfluorobutylation of a series of benzo(hetero)aromatic compounds without formal leaving groups is achieved efficaciously in organic solvent: water mixtures under photostimulation. The methodology is compared to previously reported trifluoromethylation strategies of these nuclei in terms of product yields and regioselectivity. The reaction is a radical homolytic aromatic substitution process, where the perfluoroalkyl-substituted cyclohexadienyl radical intermediate is first oxidized and then a proton transfer sequence ensues the products.","palabras_clave":"radical perfluoroalkylation|aqueous media"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38748,"idioma_id":4,"titulo":"Improving clustering with metabolic pathway data","resumen":"Background: It is a common practice in bioinformatics to validate each group returned by a clustering algorithm through manual analysis, according to a-priori biological knowledge. This procedure helps finding functionally related patterns to propose hypotheses for their behavior and the biological processes involved. Therefore, this knowledge is used only as a second step, after data are just clustered according to their expression patterns. Thus, it could be very useful to be able to improve the clustering of biological data by incorporating prior knowledge into the cluster formation itself, in order to enhance the biological value of the clusters.  Results: A novel training algorithm for clustering is presented, which evaluates the biological internal connections of the data points while the clusters are being formed. Within this training algorithm, the calculation of distances among data points and neurons centroids includes a new term based on information from well-known metabolic pathways. The standard self-organizing map (SOM) training versus the biologically-inspired SOM (bSOM) training were tested with two real data sets of transcripts and metabolites from Solanum lycopersicum and Arabidopsis thaliana species. Classical data mining validation measures were used to evaluate the clustering solutions obtained by both algorithms. Moreover, a new measure that takes into account the biological connectivity of the clusters was applied. The results of bSOM show important improvements in the convergence and performance for the proposed clustering method in comparison to standard SOM training, in particular, from the application point of view.  Conclusions: Analyses of the clusters obtained with bSOM indicate that including biological information during training can certainly increase the biological value of the clusters found with the proposed method. It is worth to highlight that this fact has effectively improved the results, which can simplify their further analysis.","palabras_clave":"Clustering|SOM training|Pathway data"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38749,"idioma_id":4,"titulo":"Natural occurring epialleles determine vitamin E accumulation in tomato fruits","resumen":"Vitamin E (VTE) content is a low heritability nutritional trait for which the geneticdeterminants are poorly understood. Here, we focus on a previously detected major tomatoVTE quantitative trait loci (QTL; mQTL9-2-6) and identify the causal gene as one encoding a2-methyl-6-phytylquinol methyltransferase (namely VTE3(1)) that catalyses one of the finalsteps in the biosynthesis of g- and a-tocopherols, which are the main forms of VTE. Byreverse genetic approaches, expression analyses, siRNA profiling and DNA methylationassays, we demonstrate that mQTL9-2-6 is an expression QTL associated with differentialmethylation of a SINE retrotransposon located in the promoter region of VTE3(1). PromoterDNA methylation can be spontaneously reverted leading to different epialleles affectingVTE3(1) expression and VTE content in fruits. These findings indicate therefore that naturallyoccurring epialleles are responsible for regulation of a nutritionally important metabolic QTLand provide direct evidence of a role for epigenetics in the determination of agronomic traits.","palabras_clave":"Biological Sciences|Genetics|Plant Sciences"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38750,"idioma_id":4,"titulo":"Lipoxygenase activation in peanut seed cultivars resistant and susceptible to Aspergillus parasiticus colonization","resumen":"Accumulative evidence indicates that the lipoxygenase (LOX) pathway  plays a significant role in the Aspergillus?seed interaction, such as  interfering with activities of endogenous fungal oxylipins or producing  antimicrobial compounds and signaling molecules. In this study, we  characterized the LOX pathway in peanut seed during Aspergillus  parasiticus colonization in a model of two cultivars distinguished asresistant (?PI337394?) and susceptible (?Florman INTA?) to Aspergillus  spp. infection and aflatoxin contamination. The LOX activity together  with the content of LOX substrate and LOX products demonstrated the  presence of a differential response mechanism to A. parasiticus infection  between cultivars. Our findings suggest that this mechanism is under  transcriptional control of previously identified (LOX 2 and LOX 3) and  novel (LOX 4 and LOX 5) LOX genes. The results of this study support  the role of these enzymes in defense during fungus infection in peanut  seed.","palabras_clave":"Aspergillus|Peanut|Aflatoxin contamination|LOX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38752,"idioma_id":4,"titulo":"Methylene blue photocatalytic mineralization under visible irradiation on TiO2 thin films doped with chromium","resumen":"We studied changes in structural, optical and photocatalytic properties of TiO2thin films due to dopingprocess with chromium. Powders of undoped TiO2and chromium-doped TiO2(Cr:TiO2) were synthe-sized by sol-gel method and, thin films were deposited by doctor blade method. The properties of thethin films were studied by X-ray diffraction (XRD), infrared spectroscopy (IR) and diffuse reflectance.The XRD patterns indicated that doping process changed the crystalline phases radio of TiO2thin films,furthermore, the optical analysis showed that band gap value of Cr:TiO2thin films was 31% fewer thanundoped TiO2thin films. Along, Langmuir-Hinshelwood model was used to obtain kinetic information ofthe photo-mineralization process; results indicated that photocatalytic activity of Cr:TiO2thin films werefour times better than undoped TiO2thin films; finally the synergic effect was tested by addition of theH2O2, photocatalytic yield was improved from 26% to 61% when methylene blue photo-mineralizationwas assisted with slightly amount of H2O2.","palabras_clave":"Doping|Thin film|Band gap|Photocatalysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38753,"idioma_id":5,"titulo":"Una estrategia didáctica para la formación de educadores en salud en Brasil: la indagación dialógica problematizadora","resumen":"El trabajo presentauna propuesta didáctica para la formación docente de profesionales del área dela salud denominada?IndagaciónDialógica Problematizadora? (IDP) y probada en el espacio curricular ?Formacióndidáctico-pedagógica en salud? del Centro de Desarrollo de la EnseñanzaSuperior en Salud (CEDESS), Universidad Federal de San Pablo. La misma sediseñó en el marco de un proyecto binacional entre Brasil y Argentina, y se desarrollóen formato presencial y virtual. La implementación de IDP permitió generar unadinámica comunicacional coherente con el posicionamiento constructivista yposibilitar un cambio en las formas comunicativas del docente y de los alumnos,guiadas desde la problematización de situaciones cercanas a las experiencias delos mismos. La implementación de esta innovación educativa fue coherente con loscambios curriculares derivados de las actuales políticas de salud para Brasil","palabras_clave":"Interaccion|problematizacion|enseñanza |discurso"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38754,"idioma_id":5,"titulo":"Función utópica y condición humana. Inflexiones a partir de los trazos de Arturo Andrés Roig","resumen":"Centramos la atención en la noción de función utópica del pensamiento de Arturo Andrés Roig. El problema se aborda partiendo del vínculo que se establece entre la función utópica y la condición humana. Apelamos al análisis de algunos textos de Ernst Bloch para mostrar los argumentos que esgrime en relación con el tratamiento de la utopía. A partir de la consideración de la función utópica como un ejercicio crítico mostramos que esta función implica un modo de habitar el hombre en el mundo. En otras palabras, trazamos un itinerario que lleva el propósito de esclarecer uno de los ejes que atraviesa la obra de Arturo Andrés Roig: la dimensión antropológica.","palabras_clave":"ARTURO ANDRÉS ROIG|FUNCIÓN UTÓPICA|CONDICIÓN HUMANA|A PRIORI ANTROPOLÓGICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38755,"idioma_id":4,"titulo":"A method to improve the analysis of cluster ensembles","resumen":"Clustering is fundamental to understand the structure of data. In the past decade the cluster ensemble problem has been introduced, which combines a set of partitions (an ensemble) of the data to obtain a single consensus solution that outperforms all the ensemble members. However, there is disagreement about which are the best ensemble characteristics to obtain a good performance: some authors have suggested that highly different partitions within the ensemble are beneficial for the final performance, whereas others have stated that medium diversity among them is better.While there are several measures to quantify the diversity, a better method to analyze the best ensemble characteristics is necessary. This paper introduces a new ensemble generation strategy and a method to make slight changes in its structure.Experimental results on six datasets suggest that this is an important step towards a more systematic approach to analyze the impact of the ensemble characteristics on the overall consensus performance.","palabras_clave":"Consensus Clustering|Ensemble Diversity|Cluster Ensemble Generation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38756,"idioma_id":5,"titulo":"An\u0013alisis de estabilidad en clusters solapados","resumen":"Analizar la estabilidad de una solución de clustering implica medir la capacidad de un algoritmo para producir resultados similares dada una misma fuente de datos de entrada.Los índices de validación externa permiten cuantificar dicha similitud entre un par de soluciones de clustering. Dentro de los índices clásicos más utilizados es posible validar soluciones con clusters no solapados, en donde cada patrón sólo puede pertenecer a un cluster.Sin embargo, en aplicaciones prácticas, generalmente se dan situaciones en las queun patrón podría poseer más de una etiqueta. En este trabajo se analiza uníndice de validación externa desde un enfoque probabilístico y se provee una reformulación aplicable a soluciones con clusters solapados. Luego de presentar el nuevo índice, se muestran y discuten resultados de experimentos realizados sobre ejemplos artificiales y bases de datos reales.Los resultados muestran cómo el nuevo índice puede medir adecuadamente la similitud entre clusters solapados,permitiendo así analizar la estabilidad en ambos casos.","palabras_clave":"Análisis de estabilidad|Clusters solapados|Medida de validación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38757,"idioma_id":4,"titulo":"Brucella alters the immune response in a prpA-dependent manner","resumen":"Brucellosis, a disease caused by the gram-negative bacterium Brucella sp, is a widespread zoonosis that inflicts important animal and human health problems, especially in developing countries. One of the hallmarks of Brucella infection is its capacity to establish a chronic infection, characteristic that depends on a wide repertoire of virulence factors among which are immunomodulatory proteins such as PrpA (encoding the proline racemase protein A or hydroxyproline-2-epimerase), involved in the establishment of the chronic phase of the infectious process that we have previously identified and characterized. We report here that, in vivo, B. abortus prpA is responsible for an increment in the B-cell number and in the specific antibody response and that these antibodies promote cell infection. We additionally found that Brucella alters the cytokine levels of IFN-&#947;, IL-10, TGF&#946;1 and TNF&#945; during the acute phase of the infectious process in a prpA dependent manner.","palabras_clave":"Brucella|prpA|immunomodulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38758,"idioma_id":4,"titulo":"Atomic resolution imaging and spectroscopy of barium atoms and functional groups on graphene oxide","resumen":"    We present an  atomic resolution transmission electron microscopy (TEM) and scanning TEM (STEM)  study of the local structure and composition of graphene oxide modified withBa2+. In our experiments, which  arecarried out at 80kV, the acquisition of contamination-free high-resolution STEM  images is only possible while heating the sample above 400C using a highly stable  heating holder. Ba atoms are identified spectroscopically in electron energy-loss  spectrum images taken at 800C and are associated with bright contrast in high-angle  annular dark-field STEM images. The spectrum images also  show that Ca and O occur together and that Ba is not associated with a significant concentration of O. The electron  dose used for spectrum imaging results in beam damage to the specimen, even at elevated  temperature. It is also possible to identify Ba atoms in high-resolution TEM images  acquired using shorter exposure times at room temperature, thereby allowing the  structure of graphene oxide to be studied using complementary TEM and STEM techniques  over a wide range of temperatures.  ","palabras_clave":"Graphene oxide|single atom imaging and spectroscopy|functional groups|aberration correction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38759,"idioma_id":4,"titulo":"Separation of Acylglycerides Obtained by Enzymatic Esterification Using Solvent Extraction","resumen":"New avenues to add value to glycerol are currently being explored. One of them is the synthesis of structured lipids through glycerol esterification. In this work we have analyzed the recovery and purification of dicaprin obtained by esterification of glycerol with capric acid (C) in heptane, mediated by Lipozyme RM IM. This is an intermediate step to obtain lipids MLM. In the first stage, the diglyceride synthesis MGM (being G a central HC-OH) was carried out. When M = C, the diglyceride is CGC. Recovery of the diglyceride CGC is required to carry out the esterification of the sn-2 position with palmitic acid (P), thus obtaining the triglyceride CPC. Different solvents were evaluated using Ecofac 1.0 (a molecular design software solvent) through a theoretical approach to explore the best solvents for the acylglycerides separation. Then, the performance of the selected solvents to separate dicaprin from mono and tricaprin was experimentally studied in a liquid-liquid extraction process. Previously, the remaining fatty acid had been neutralized. With liquid-liquid extraction in three simple steps, using ethanol\/water, 94 % of the dicaprin obtained by enzymatic esterification was recovered with a purity of 89 % (wt%). It was also possible to obtain dicaprin with a purity of 97 % but with a yield of 56 %. © 2013 AOCS.","palabras_clave":"SEPARATION|FATTY ACIDS|ACYLGLYCERIDES|EXTRACTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38761,"idioma_id":4,"titulo":"Oxidative stress induced by Atrazine in Palaemonetes argentinus:","resumen":"The widespread  contamination and persistence of the herbicide atrazine residues in the environment  resulted in the exposure of non-target organisms. The present study was  undertaken to investigate the effect of atrazine in the response of oxidative  stress biomarkers in the freshwater shrimp Palaemonetes argentinus and the  protective effect of vitamin-E against atrazine-induced toxicity. Therefore,  two batches of P.argentinus were fed for 21  days with a commercial food enriched in proteins (D1) or with D2, composed of  D1 enriched with vitamin-E. Subsequently, half of individuals of each group  were exposed to atrazine (0.4 mg L-133 ) for 24 h and the others remained as controls.    Atrazine promoted  oxidative stress in P.argentinus fed with D1 as  indicated by enhanced H2O2 content and induction of SOD, GSTs and GR. This antioxidant activity would prevent the  increment of TBARs in the shrimp tissues. P.argentinus fed with D2 &nbsp;could reverse the response of the biomarkers  measured. However, the activation of antioxidants response had an energetic cost, which was revealed by a  decrease in lipids and glycogen storage in shrimps. These results show the modulatory effect of  vit-E on oxidative stress and its potential use as an effective antioxidant to be applied  in chemoprotection strategies during aquaculture.","palabras_clave":"Oxidative stress|Tocopherols|herbicides|freshwater invertebrates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38762,"idioma_id":4,"titulo":"Biological parameters of franciscana dolphins,  Pontoporia blainvillei,  bycaught in artisanal fisheries off southern Buenos Aires, Argentina.","resumen":"The franciscana dolphin (Pontoporia blainvillei) is a small coastal dolphin endemic to the south-western Atlantic Ocean.  Incidental captures in fishing gillnets is possibly the greatest conservation concern for this species, and occurs within most  of its geographical distribution. The aim of this paper is to determine the biological parameters of franciscana dolphin  by-caught from artisanal coastal fisheries of the southern Buenos Aires province, Argentina. Between 2003 and 2009, carcasses  of 54 incidentally captured franciscanas were collected. The age, sexual and physical maturity and body condition of each  specimen was determined. The sex-ratio of the by-caught dolphins did not differ from parity and, consistent with other  areas, juveniles younger than 4 yr old were captured in higher proportion (69%). In addition, 74% of the entangled  animals were sexually immature and 85% physically immature. Sexually immature dolphins were predominant in the  spring, a period which coincides with the breeding season. An assessment of the body condition of captured franciscanas suggests  that entanglements were not associated with a disease or physiological disorder. The results presented here are important  to assess the impact of artisanal fisheries on the population of franciscana dolphins in the southernmost area of its  distribution.","palabras_clave":"FRANCISCANA DOLPHIN|PONTOPORIA BLAINVILLEI|BIOLOGICAL PARAMETERS|SEXUAL MATURITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38763,"idioma_id":4,"titulo":"The influence of sodium chloride reduction on physicochemical, biochemical, rheological and sensory characteristics of Mozzarella cheese","resumen":"Excessive intake of sodium has beenassociated with harmful effects on human health. Therefore, salt reduction inmanufactured products is been targeted as a way to reduce dietary sodiumintake. Sodium chloride (NaCl) plays an important role in cheese, and reducingthe NaCl level in cheese may adversely affect its characteristics. Ourobjective was to evaluate the influence of different levels of salt reductionon the physicochemical, biochemical, rheological, and sensory characteristicsof Mozzarella cheese. Samples were brine-salted for different periods to obtaincheeses with different levels of salt reduction (C: control cheese; S1: cheesewith 60% salt reduction, S2: cheese with 35% salt reduction). Samples wereanalysed during 43 days of ripening. As expected, salt flavour intensitydecreased with a decrease in NaCl levels. Small differences between control andexperimental cheeses due to salting condition were observed in moisturecontent, water activity, maturation index, &#945;s1-casein, &#945;s1-I-casein, crossovertemperature (when the elastic component equals the viscous component) and insome sensory attributes (aroma, colour, global flavour and creaminess). No significantdifferences due to salting condition were observed in pH, &#947;-casein, &#946;-casein degradation,activation energy (parameter that quantifies the matrix degradation with heating),residual flavour, acidity and bitter taste. Taking into account the minor differencesobserved after the significant salt reduction analysed, it is considered that decreasingNaCl may not jeopardise the standard Mozzarella cheese quality.","palabras_clave":"SALT REDUCTION|MOZZARELLA|CHEESE|CHARACTERISTICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38764,"idioma_id":4,"titulo":"Effect of increased initial ripening temperature on the sensory characteristics of Reggianito cheese","resumen":"The effects of increased initial ripening temperature on sensory characteristics of Reggianito cheesewere evaluated considering different temperature?time combinations. Control cheeses stored at12 °C for 6 months and experimental cheeses stored at 20 °C for 2 or 4 weeks then at 12 °C up to6 months were analysed at 61, 124, and 180 days of ripening by physicochemical, microbiologicaland quantitative descriptive analysis. The use of an initial increased ripening temperature results incontrolled and limited changes on mesophilic lactobacilli growth and in a mild acceleration of thesensory characteristic development of Reggianito cheese.","palabras_clave":"REGGIANITO|CHEESE|RIPENING|SENSORY CHARACTERISTICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38765,"idioma_id":4,"titulo":"Correlation between radiation damage and magnetic properties in reactor vessel steels","resumen":"Since reactor pressure vessel steels are ferromagnetic, provide a convenient means to monitor changes in the mechanical properties of the material upon irradiation with high energy particles, by measuring their magnetic properties. Here, we discuss the correlation between mechanical and magnetic properties and  microstructure, by studying the flux effect on the nuclear pressure vessel steel used in reactors currently under construction in Argentina. Charpy-V notched specimens of this steel were irradiated in the RA1 experimental reactor at 275 C with two lead factors (LFs), 93 and 183. The magnetic properties were studied by means of DC magnetometry and ferromagnetic resonance. The results show that the coercivefield and magnetic anisotropy spatial distribution are sensitive to the LF and can be explained by taking into account the evolution of the microstructure with this parameter. The saturation magnetization shows a dominant dependence on the accumulated damage.  Consequently, the mentioned techniques are suitable to estimate the degradation of the reactor vessel steel.","palabras_clave":"NUCLEAR REACTOR VESSEL|MAGNETIC PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38766,"idioma_id":4,"titulo":"Effect of the addition of nanoclays on the water absorption and mechanical properties of glass fiber\/up resin composites","resumen":"Mechanical performance of composite materials must remain satisfactory during their life in service. However, composite  structures such as wind blades are usually exposed to humid and severe environments, and the absorbed water can  degrade the fiber?matrix interface decreasing the composite overall performance. Dual scale (nano-micro) composites  can be obtained by adding nanoparticles to the polyester resin and reinforcing that nanomaterial with a glass fiber mat.  These materials have good potential in the production of composite parts such as wind blades because nanoparticles  dispersed in the polymer matrix could lower the water absorption of the composites and improve their performance in  humid environments. However, nanosized reinforcing particles have high internal surface and therefore they tend to  agglomerate and are difficult to disperse homogeneously in the polymeric matrix. Moreover, the final properties of the  nanocomposites are strongly influenced by clay particles? morphology and dispersion. In this work, the effect of the  addition of pristine and organomodified nanoclays on the water absorption and mechanical properties of glass fiber\/  unsaturated polyester resin composites was studied. Results showed that the chemical treatments were effective in  improving clay dispersion, reducing water absorption, and increasing the composites? performance in humid environments.  In addition, this work presents a procedure to use water absorption tests as means of accelerated humidity  absorption tests.","palabras_clave":"Polymer matrix composites|nanoclays|water absorption|nanostructures|mechanical properties|wind blades"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38767,"idioma_id":4,"titulo":"Active polymers containing Lactobacillus curvatus CRL705 bacteriocins: Effectiveness assessment in Wieners","resumen":"Bacteriocins from lactic acid bacteria have potential as natural food preservatives. In this study two active (synthetic and gluten) films were obtained by the incorporation of lactocin 705 and lactocin AL705, bacteriocins produced by Lactobacillus curvatus CRL705 with antimicrobial activity against spoilage lactic acid bacteria and Listeria. Antimicrobial film effectiveness was determined in Wieners inoculated with Lactobacillus plantarum CRL691 and Listeria innocua 7 (104 CFU\/g) stored at 5 °C during 45 days. Active and control (absence of bacteriocins) packages were prepared and bacterial counts in selective media were carried out. Visual inspection and pH measurement of Wieners were also performed. Typical growth of both inoculated microorganisms was observed in control packages which reached 106?107 CFU\/g at the end of storage period. In the active packages, L. innocua 7 was effectively inhibited (2.5 log cycles reduction at day 45), while L. plantarum CRL691 was only slightly inhibited (0.5 log cycles) up to the second week of storage, then counts around 106?107 CFU\/g were reached. Changes in pH values from 6.3 to 5.8 were produced and gas formation was observed in active and control packages. The low inhibitory effectiveness against lactic acid bacteria is in correlation with the low activity observed for lactocin 705 in the presence of fat; Wieners fat content (20?30%) may adversely affect antimicrobial activity. This study supports the feasibility of using polymers activated with L. curvatus CRL705 bacteriocins to control Listeria on the surface of Wieners and highlights the importance of evaluating antimicrobial packaging systems for each particular food application.","palabras_clave":"ANTI-LISTERIA|ANTIMICROBIAL FOOD PACKAGING|BACTERIOCINS|LACTIC ACID BACTERIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38768,"idioma_id":4,"titulo":"Photosynthesis and fluorescence responses of Jatropha curcas to chilling and freezing stress during early vegetative stages","resumen":"The aim of the work is to analyze, in Jatropha curcas seedlings, the impact of brief expositions to chilling (48h at 4ºC) and freezing (2h at -1, -2 and -3ºC) on leaf photosynthesis at saturating irradiances (Amax), and the role of stomatal conductance (gs) and photochemical activity. Two similar experiments were made in pots at outdoors; treatments were performed in climate chambers at the stage of four expanded leaves per plant, and then returned to outdoors. Leaf gas exchange, water status and fluorescence variables were measured at 1 and 30 days after the end of the treatment (DAT). At 1 DAT, Amax and gs were reduced up to 75% and 100% in chilling and freezing treatments, respectively. However, the intercellular CO2 concentration (Ci) showed an inverse pattern, discarding a determinant role in Amax reductions. A lower efficiency electron use for photosynthesis was detected for plants subjected to chilling and freezing stress. The potential efficiency of PSII (Fv\/Fm), chlorophyll content (Chl) and relative water content (RWC) were only affected by the lower freezing treatments, while chilling and intermediate freezing plants showed an increase of the non photochemical quenching (NPQ). Leaf death occurred in the lower freezing treatments, while several residual effects on Amax, gs and electron transport rate (ETR) were also observed at 30 DAT in the survival treatments. This work sheds light on the determinant processes involved in the depletion of photosynthesis by chilling and freezing injuries and reveals that low temperatures could be very detrimental over J. curcas growth and, hence, crop establishment.","palabras_clave":"Jatropha curcas|Photosynthesis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38769,"idioma_id":4,"titulo":"Development of an active wheat gluten film with Lactobacillus curvatus CRL705 bacteriocins and a study of its antimicrobial performance during ageing","resumen":"Antimicrobial wheat gluten film was obtained at pilot scale by Lactobacillus curvatus CRL705 bacteriocins inclusion in the film-forming solution. Bacteriocins´ minimum inhibitory concentration for the film activation was 2133 AU cm(-3) (lactocin AL705) and 267 AU cm(-3) (lactocin 705). Mechanical and barrier properties as well as film ageing kinetics were not significantly affected by the addition of bacteriocins. The antimicrobial film performance during ageing was assessed. Film activity against Listeria innocua 7 and Lactobacillus plantarum CRL691 was observed over 50 days of ageing. Even when the release of bacteriocins from the film upon water contact was observed for both bacteriocins at the beginning of the ageing period, and anti-Listeria activity was delivered to the simulant up to the 15th day of ageing, film residual activity for both bacteriocins was observed over 50 days. The results confirm the potential of a gluten film doped with L. curvatus CRL705 bacteriocins as a carrier of bacteriocins to avoid Listeria and lactic acid bacterial growth, thus enhancing quality and safety in foods.","palabras_clave":"ACTIVE BIO-BASED POLYMER|ANTI-LISTERIA|BACTERIOCINS|ANTIMICROBIAL FILM PERFORMANCE DURING AGEING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38770,"idioma_id":4,"titulo":"Random Inbreeding, Isonymy and Population Isolates in Argentina","resumen":"Population isolates are an important tool in identifying and mapping genes of Mendelian diseases and complex traits. The geographical identification of isolates represents a priority from a genetic and health care standpoint. The purpose of this study is to analyze the spatial distribution of consanguinity by random isonymy (F ST) in Argentina and its relationship with the isolates previously identified in the country. F ST was estimated from the surname distribution of 22.6 million electors registered for the year 2001 in the 24 provinces, 5 geographical regions, and 510 departments of the country. Statistically significant spatial clustering of F ST was determined using the SaTScan V5.1 software. F ST exhibited a marked regional and departamental variation, showing the highest values towards the North and West of Argentina. The clusters of high consanguinity by random isonymy followed the same distribution. Recognized Argentinean genetic isolates are mainly localized at the north of the country, in clusters of high inbreeding. Given the availability of listings of surnames in high-capacity storage devices for different countries, estimating F ST from them can provide information on inbreeding for all levels of administrative subdivisions, to be used as a demographic variable for the identification of isolates within the country for public health purposes.","palabras_clave":"Isonymy|Random inbreeding"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38771,"idioma_id":4,"titulo":"Implications of the Admixture Process in Skin Color Molecular Assessment","resumen":"The understanding of the complex genotype-phenotype architecture of human pigmentation has clear implications for the  evolutionary history of humans, as well as for medical and forensic practices. Although dozens of genes have previously  been associated with human skin color, knowledge about this trait remains incomplete. In particular, studies focusing on  populations outside the European-North American axis are rare, and, until now, admixed populations have seldom been  considered. The present study was designed to help fill this gap. Our objective was to evaluate possible associations of 18  single nucleotide polymorphisms (SNPs), located within nine genes, and one pseudogene with the Melanin Index (MI) in  two admixed Brazilian populations (Gaucho, N = 352; Baiano, N = 148) with different histories of geographic and ethnic  colonization. Of the total sample, four markers were found to be significantly associated with skin color, but only two  (SLC24A5 rs1426654, and SLC45A2 rs16891982) were consistently associated with MI in both samples (Gaucho and Baiano).  Therefore, only these 2 SNPs should be preliminarily considered to have forensic significance because they consistently  showed the association independently of the admixture level of the populations studied. We do not discard that the other  two markers (HERC2 rs1129038 and TYR rs1126809) might be also relevant to admixed samples, but additional studies are  necessary to confirm the real importance of these markers for skin pigmentation. Finally, our study shows associations of  some SNPs with MI in a modern Brazilian admixed sample, with possible applications in forensic genetics. Some classical  genetic markers in Euro-North American populations are not associated with MI in our sample. Our results point out the  relevance of considering population differences in selecting an appropriate set of SNPs as phenotype predictors in forensic  practice.","palabras_clave":"genotype-phenotype|human pigmentation|SNPs"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38772,"idioma_id":4,"titulo":"Magnetic Study of a Pentanuclear {Co2 IIICo3 II} Cluster with a Bent {CoII 3}  Motif","resumen":"We have synthesised and structurally characterised a new   pentanuclear mixed-valent cobalt cluster of formula [CoII 3CoIII2(OH)2(piv)6(L)2(H2O)4] (piv = trimethylacetate, H2L = salicylideneanthranillic acid) from reaction of a di-nuclear cobalt pivalate precursor with a Schiff base type ligand under mild reaction conditions. The core structure can be conveniently described as two fused Co3?&#956;3?OH triangles with a strict unique sharing vertex point. A complete picture of the magnetic behaviour of this compound is presented.  Through combined use of susceptibility, magnetisation, and EPR data as well as broken-symmetry DFT calculations, we have supported the magnetic data that show weak and anisotropic exchange interaction between CoII ions affording an Seff = 1\/2 ground state that is not completely isolated from the low-lying excited doublets at low temperature. Under the optimum applied field of 2 kOe, a frequency-dependent out-of-phase susceptibility signal can be observed below 4 K.  However, no reliable relaxation rates could be extracted due to the narrow temperature range in which this behaviour was observed.","palabras_clave":"CLUSTER COMPOUNDS|DENSITY FUNCTIONAL CALCULATIONS|MIXED-VALENT COMPOUNDS|MAGNETIC PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38773,"idioma_id":4,"titulo":"The  tomato  phosphatidylinositol-phospholipase  C2  (SlPLC2)  is  required  for  defense  gene  induction  by  the fungal  elicitor  xylanase","resumen":"The tomato [Solanum lycopersicum (Sl)] phosphatidylinositol-phospholipase C  (PI-PLC) gene family is composed of six members, named SlPLC1 to SlPLC6,  differentially regulated upon pathogen a 40 ttack. We have previously shown that  the fungal elicitor xylanase rapidly induces nitric oxide (NO), which is required  for PI-PLCs activity and downstream defense responses in tomato cell  suspensions. Here, we show that all six SlPLC genes are expressed in tomato  cell suspensions. Treatment of the cells with xylanase induces an early increase  45 in SlPLC5 transcript levels, followed by a raise of the amount of  SlPLC2 transcripts. The production of NO is required to augment SlPLC5  transcript levels in xylanase-treated tomato cells. Xylanase also induces  SlPLC2 and SlPLC5 transcript levels in planta. We knocked-down the  expression of SlPLC2 and SlPLC5 by virus-induced gene silencing. We found  50 that SlPLC2 is required for xylanase-induced expression of the defense-related  genes PR1 and HSR203J","palabras_clave":"DEFENSE GENE|PHOSPHOLIPID SIGNALLING|PATHOGEN-ASSOCIATED MOLECULAR PATTERN|PHOSPHATIDIC ACID"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38774,"idioma_id":4,"titulo":"Comparison of strategies for the production of FMDV empty capsids using the baculovirus vector system","resumen":"Recombinant FMDV empty capsids have been  produced in insect cells and larvae using the baculovirus  expression system, although protein yield and efficiency of  capsid assembly have been highly variable. In this work,  two strategies were compared for the expression of FMDV  A\/Arg\/01 empty capsids: infection with a dual-promoter  baculovirus vector coding for the capsid precursor (P12A)  and the protease 3C under the control of the polyhedrin and  p10 promoters, respectively (BacP12A-3C), or a singlepromoter  vector coding the P12A3C cassette (Bac-  P12A3C). Expression levels and assembly into empty  capsids were analyzed in insect cells and larvae. We  observed that the use of the single-promoter vector allowed  higher levels of expression both in insect cells and larvae.  Recombinant capsid proteins produced by both vectors  were recognized by monoclonal antibodies (mAbs) directed  against conformational epitopes of FMDV A\/Arg\/01  and proved to self-assemble into empty capsids (75S) and  pentamers (12S) when analyzed by sucrose gradient  centrifugation","palabras_clave":"VIRUS DE LA FIEBRE AFTOSA|PROTEÍNAS RECOMBINANTES|BACULOVIRUS|BIOTECNOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38775,"idioma_id":4,"titulo":"Uncropped field margins to mitigate soil carbon losses in agricultural landscapes","resumen":"tAgricultural intensification is a major cause of habitat transformation. Continuous cropping alters ecosys-tem services, such as biodiversity and carbon sequestration. Empirical evidence from agricultural lands inArgentina has shown that permanently vegetated areas imbedded in the agricultural matrix (uncroppedmargins) play a critical role in plant and animal communities compared to the usual situation of cropssurrounded by other crops (cultivated margins). However, the potential impact of uncropped margins ontheir own carbon stocks and fluxes and on those of their neighbouring cropped fields remains unknown.We investigated the impact of uncropped (herbaceous and woody) and cropped margins (cultivatedfields) on their own topsoil carbon stocks and fluxes and on those of their neighbouring croplands (soy-bean fields). We identified soybean fields adjacent to one of three possible margin types: herbaceous orwoody permanent vegetation, and field crop, which acted as control because it is the most frequent situa-tion in the region. In each of these margin?soybean pairs, we sampled transects from the margin towardsthe centre of the soybean field (50 m). Woody margins showed the greatest soil carbon content, the leastdecomposable plant litter and the greatest influence on the neighbouring crop. Conversely, herbaceousmargins had the lowest litter accumulation and the most decomposable litter. Only woody margins influ-enced soil properties in the first metres of the cropped neighbourhood. Centres of soybean fields weresimilar, irrespective of margin type. The decomposition of common substrates was not affected by margintype. These findings suggest that woody margins are the unique element of the current landscape witha potential to mitigate soil carbon loss from agroecosystems, albeit spatially limited. In contrast, the lowbiomass and highly decomposable litter of herbaceous margins reveal the urgent need to re-think theircurrent management strategies.","palabras_clave":"AGRICULTURE|INTENSIFICATION|SOIL CARBON"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38776,"idioma_id":4,"titulo":"Epigeal  arthropod  communities  in  intensively  farmed  landscapes: Effects  of  land  use  mosaics,  neighbourhood  heterogeneity, and  field  position","resumen":"Trophic  guilds  of  epigeal  arthropods  regulating  insect  pest  populations  may  be  affected  by  factors  acting  across  spatial  scales.  Although  the  influence  of  landscape  factors  associated  with  farming  effects  on arthropod  assemblages  has  received increasing  attention  in  the  last  decades,  most  research  was  carried out  in  fine-grain  landscapes  by  comparing  conventional  and  organic  cropping  systems.  Here,  we  aimed at  identifying  the  role  of  fencerows  and  crop  heterogeneity  in  defining  arthropod  diversity  in  intensively farmed,  coarse-grain  landscapes.  Hence,  we  developed  a  multi-scale  heterogeneity  approach  based  on fitting  linear-mixed  models  to  elucidate  the  effects  of  three  spatial  scales  (local,  neighbouring  crop  types, and  landscape)  on arthropod  diversity.  Mixed  models  were  fitted to  arthropod  data  obtained  by  pitfall trap  samplings  in  22  field  pairs.  Field  position  was  a  major  determinant  of  arthropod  species  diversity at  local  scale,  due  to  the  contrasting  disturbance  regimes  of  fencerows  and  adjoining  field  edges.  Fence density  at  landscape  scale contributed  to  retain  diverse  arthropod  assemblages  in  farmland  mosaics  by supplying  habitats  and  refuges.  In  addition,  extended  fence  network  may  function  as  corridors  for  dispersal,  increasing  connectivity  between  dissimilar  habitats.  Fence  habitats,  as  well  as  their  density  in  the landscapes,  enhance  both  richness  and  abundance  of  beneficial  arthropods.  Our  findings  indicate  that  the overall  arthropod  diversity  was  benefited  by  landscape  complexity,  being  the  presence  and  density  of fencerows  key  landscape  attributes.  Contrasting  disturbance  regimes  at  different  field  positions  emerged as  a  major  driver  modulating  arthropod  species  diversity  in  intensively  managed  farmland  mosaics.  Noncropped habitats  associated  with  fencerows  and  field  margins  play  key ecological  functions  that  are  of vital  importance  for  providing ecosystem  services  in  agro-ecosystems.  Complex  landscapes  may  help  to conserve  overall  plant  diversity  in  agro-ecosystems,  as  well as  the  spillover  of  arthropod  species  from fencerows  towards  crop  fields.  Even  in  heavily  intensified  landscapes,  where  crop diversity  is  the  main source  of  heterogeneity,  promoting  measures  intended  for  both  restoring  and  managing  fencerow  and non-cropped  habitats  through  landscape  planning  will  contribute  to  maintain  arthropod  richness  (almost 70%  of  total  richness)  across  the  entire  landscape.","palabras_clave":"BIODIVERSITY|LANDSCAPE HOMOGENISATION|NEIGHBOURING EFFECTS|ROLLING PAMPAS|SPATIAL SCALE|SPILLOVER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38777,"idioma_id":4,"titulo":"Prenatal Bisphenol A exposure delays the development of the male rat mammary gland","resumen":"Our aims were to evaluate whether exposure to Bisphenol A (BPA) modifies the development of the male rat mammary gland (MG) and to evaluate whether this modification is gender specific. From gestational day 9, pregnant rats were exposed either subcutaneously to 0, 25 or 250 &#956;g BPA\/kgbw\/day until parturition or orally to 0 and 64 &#956;g BPA\/kgbw\/day until weaning. MG development was analyzed on postnatal days (PND) 5, 15 and 30. On PND30, steroid hormone receptor expression and mammary growth were also evaluated. On PND30, the exposure to 64BPA and 250BPA induced a delay in male MG development, evidenced by reduced ductal growth, decreased number of terminal structures and lower expression of androgen receptor (AR). In contrast, female mammary ductal growth was altered only by 250BPA. Regardless of the administration route and length of the exposure period, BPA induced a delay in MG development and modified AR expression in prepubertal male rats.","palabras_clave":"BISPHENOL A|MALE|MAMMARY GLAND DEVELOPMENT|ENDOCRINE DISRUPTOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38778,"idioma_id":5,"titulo":"DISTRIBUCIÓN GEOGRÁFICA DE Calomys musculinus (RODENTIA, SIGMODONTINAE) EN PATAGONIA","resumen":"El objetivo de este trabajo es documentar ?sobre la base de información tanto publicada como inédita- la distribución geográfica del sigmodontino  Calomys musculinus  en Patagonia. Se compilaron 165 localidades de ocurrencia de las cuales 104 son novedosas. La especie se distribuye ampliamente en Patagonia. Su rango geográfico coincide, en el nordeste, con la Provincia Fitogeográfica del Monte; hacia el sur y oeste se asocia con ambientes de la franja costera y los principales valles fluviales, respectivamente. En los últimos cientos de años las poblaciones de C. musculinus han experimentado incrementos locales dramáticos, cuya vinculación con el establecimiento de oasis agrícolas resulta plausible.","palabras_clave":"Phillotini|Egagrópilas|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38779,"idioma_id":4,"titulo":"Last Glacial Maximum environments in northwestern Patagonia revealed by fossil small mammals","resumen":"Comparisons of historical and modern assemblages of mammals can yield important insights into patterns and processes of environmental change. Here, we present the first analyses of small mammal assemblages present in northern Patagonia during the last glacial maximum (LGM). Using remains obtained from owl pellets excavated from an archeological cave site (Arroyo Corral I, levels VII?V, carbon dates of 22,400?21,530 cal yr BP), we generate estimates of the minimum number of individuals for all species detected; these estimates, in turn are used to determine relative species abundances. Comparisons of these data with similar analyses of small mammal remains obtained from a second archeological site (ACoII, levels IV?V, carbon dates of 10,010?9220 cal yr BP) as well as from modern owl pellets reveal pronounced changes in relative species abundance since the LGM. In particular, Euneomys chinchilloides and Ctenomys sociabilis ? the predominant species during the LGM ? declined markedly, suggesting a change from open, bare habitat punctuated by patches of wet meadows and shrubs to the more densely vegetated mosaic of ecotone habitats found in this region today. These data provide important new insights into the environmental changes that have occurred in northern Patagonia over the last 20,000 years.","palabras_clave":"PALEOENVIRONMENTS|LAST GLACIAL MAXIMUM |RODENT ASSEMBLAGES |TAXONOMIC DIVERSITY |ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38780,"idioma_id":5,"titulo":"Micromamíferos, cambio climático e impacto antrópico: ¿Cuánto han cambiado las comunidades del sur de América del Sur en los últimos 500 años?","resumen":"Diversas evidencias sugieren que la actual configuración de las comunidades -i. e. riqueza (número de especies) y diversidad (distribución de la abundancia de especies)- de micromamíferos en el sur de América del Sur se habría generado en el período posterior a la llegada de los europeos hacia 1500 AD. En este trabajo se revisa principalmente el registro fósil para pequeños roedores y marsupiales en los últimos 500 años, con énfasis en aquellos de la región Pampeana y la Patagonia. Esta evidencia se comparó con registros actuales correspondientes a más de 700 muestras de egagrópilas de estos mismos sectores geográficos. En una primera aproximación, se destaca que la riqueza y diversidad de las comunidades de micromamíferos fue mayor en la etapa previa al impacto antrópico más profundo, con una abrupta caída de ambos parámetros hacia el presente. Se sugiere que las transformaciones producidas por la ganadería y agricultura extensivas habrían provocado una uniformidad de hábitat beneficiosa para  algunos taxones oportunistas, facilitando su dispersión y permitiendo el incremento, en algunos casos drástico, de sus poblaciones. En los últimos 500 años se registran variaciones significativas en la distribución de otros taxones, que en algunos casos implican extinciones locales involucrando cientos o miles de kilómetros. Sobre 46 especies de roedores consideradas como Preocupación Menor por la UICN y con registro fósil para este segmento temporal, 23 (50%) han experimentado retracciones en sus rangos de distribución o reducciones drásticas de su abundancia. Al menos nueve taxones se habrían extinguido completamente en América del Sur, incluyendo un marsupial, un  quiróptero y siete roedores. Fenómenos similares se registran en otras áreas del Hemisferio Sur, tanto en contextos continentales como insulares. Este panorama pone de manifiesto la necesidad de evaluar más cuidadosamente la situación de algunas especies con poblaciones consideradas como estables, pero susceptibles de verse afectadas frente a nuevos cambios extensivos en los ambientes (e. g. megaminería, expansión de la frontera agrícola), a juzgar por lo que indica el registro fósil.","palabras_clave":"ARGENTINA|DIDELPHIMORPHIA|EXTINCTIONS|SMALL MAMMALS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38781,"idioma_id":4,"titulo":"Characterization of atmospheric emission sources of heavy metals and trace elements through a local-scale monitoring network using T. capillaris","resumen":"tThis research work presents new insights regarding biomonitoring studies, source apportionment at alocal scale, and influence of wind and topography on dispersion of atmospheric pollutants in a complexscenario. The monitoring network consisted of transplanted Tillandsia capillaris biomonitors throughout3 sampling periods in order to assess the effects of the different emission sources and their atmosphericdispersions in a region from the province of Córdoba, Argentina. The elements Mn, Fe, Co, Ni, Cu, Zn,Cd and Pb, were analyzed by Flame Atomic Absorption Spectrometry (FAAS, pseudo-total metal con-tent) and As, Ba, Ca, Ce, Cr, Cs, Eu, Fe, Hf, La, Lu, Na, Rb, Sb, Sc, Se, Sm, Ta, Tb, Th, U, Yb and Zn, byNeutron Activation Analysis (NAA, total metal content). The following atmospheric emission sourceswere characterized in the study area: cement plant, with emissions of Cd, Pb, CoFAAS, Ni and Ca; wastedumping site fires, with emissions of the elements Sm, Yb, Ba, La, ZnNAA, Ce, Th and Hf; brick kilnswith emissions of the elements Na, Ba, As, Se, Cr, Tb, Sc, FeNAA, CoNAA, Ta; vehicular traffic with emis-sions of ZnFAASand Sb and soil re-suspension with emissions of Ni, ZnFAAS, Br, U, Mn, Rb and Eu. It wasnoticeable that topography played an important role in the dispersion of the pollutants in the studyarea and this was reflected in the biomonitors. Our results provide a step forward in the applicationfield of this biomonitoring species for characterizing emission sources in a complex scenario at a localscale.","palabras_clave":"T. capillaris transplants|Active biomonitoring|Local scale|Heavy metals|Trace elements"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38782,"idioma_id":4,"titulo":"Source characterization and seasonal variations of atmospheric polycyclic aromatic hydrocarbons at an industrial and semi-urban area through a local-scale biomonitoring network using T. capillaris","resumen":"Designing a network of instrumental monitoring to obtain polycyclic aromatic hydrocarbon (PAH) concentration data at many sampling sites simultaneously is difficult due to the high cost of equipment and the problem of identifying suitable sites for installation. The use of biomonitors allows accurate approximations of air pollution, covering different working scales and levels of complexity, based on the number of individuals collected or transplanted. A monitoring network, consisting of biomonitors of Tillandsia capillaris transplanted for four seasons, was designed in order to assess the effects of different emission sources and the atmospheric dispersion of PAHs at a local scale, in the town of Malagueño, Argentina. Out of the sixteen priority control PAHs listed by the United States Environmental Protection Agency (USEPA) for their mutagenic and carcinogenic properties, thirteen of them were analyzed in this study. In addition, several physiological parameters were quantified in order to try to relate the damage in the transplanted biomonitors with the air quality in the sector. The biomonitoring study allowed the spatial (in 300 km2) and temporal (over one year) variabilities in the concentrations of the PAHs emitted from multiple sources in a complex scenario to be assessed, thereby identifying marker elements from the emissions of a cement plant, biomass burning and traffic. The present study represents a different approach for analyzing the behavior of sources of emission of PAHs in space and time, and the results obtained can be compared with related sources from other regions of the world.","palabras_clave":"T. CAPILLARIS TRANSPLANTS|POLYCYCLIC AROMATIC HYDROCARBONS|PHYSIOLOGICAL PARAMETERS|SPATIO-TEMPORAL ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38784,"idioma_id":4,"titulo":"Sizing methodology for hybrid systems based on multiple renewable power sources integrated to the energy management strategy","resumen":"This work presents a design methodology for a hybrid energy system based on multiple renewable power sources and bioethanol. The new concept of generation consists on having multiple power sources such as: a PEM fuel cell system fed by the hydrogen produced by a bioethanol reformer and the wind-solar sources working all together supervised by the energy management system. The necessary heating for the bioethanol reforming reaction can be provided by the renewable sources to enhance the efficiency of the hydrogen production. It is worth noting that, from the power balance as well as backup point of views, the hybrid system is equipped with energy storage devices which also need to be designed. An optimal sizing methodology integrated with the energy management strategy  is proposed here for designing the overall hybrid system. The suggested approach is based on genetic algorithms, using historical climate data and load demands over a period of one year. Several simulation results are given to show the methodology performance in terms of loss of power supply probability (LPSP), costs and bioethanol consumption.","palabras_clave":"RENEWABLE ENERGY SOURCES|BIOETHANOL|SYSTEM SIZING|ENERGY MANAGEMENT STRATEGY|PEM FUEL CELLS|STAND ALONE POWER SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38785,"idioma_id":4,"titulo":"Endogenous endothelin 1 mediates angiotensin II-induced hypertrophy in electrically paced cardiac myocytes through EGFR transactiv ation, reactiv e oxygen species and NHE-1","resumen":"Emerging evidence supports a key role for endothelin-1 (ET-1) and the transactivation of the epidermal growth factor receptor (EGFR) in angiotensin II (Ang II) action. We aim to determine the potential role played by endogenous ET-1, EGFR transactivation and redox-dependent sodium hydrogen exchanger-1 (NHE-1) activation in the hypertrophic response to Ang II of cardiac myocytes. Electrically paced adult cat cardiomyocytes were placed in culture and stimulated with 1 nmol l-1 Ang II or 5 nmol l-1 ET-1. Ang II increased ~45 % cell surface area (CSA) and ~37 % [3H]-phenylalanine incorporation, effects that were blocked not only by losartan (Los) but also by BQ123 (AT1 and ETA receptor antagonists, respectively). Moreover, Ang II significantly increased ET-1 messenger RNA (mRNA) expression. ET-1 similarly increased myocyte CSA and protein synthesis, actions prevented by the reactive oxygen species scavenger MPG or the NHE-1 inhibitor cariporide (carip). ET-1 increased the phosphorylation of the redox-sensitive ERK1\/2-p90RSK kinases, main activators of the NHE-1. This effect was prevented by MPG and the antagonist of EGFR, AG1478. Ang II, ET-1 and EGF increased myocardial superoxide production (187&#8201;±&#8201;9 %, 149&#8201;±&#8201;8 % and 163.7&#8201;±&#8201;6 % of control, respectively) and AG1478 inhibited these effects. Interestingly, Los inhibited only Ang II whilst BQ123 cancelled both Ang II and ET-1 actions, supporting the sequential and unidirectional activation of AT1, ETA and EGFR. Based on the present evidence, we propose that endogenous ET-1 mediates the hypertrophic response to Ang II by a mechanism that involves EGFR transactivation and redox-dependent activation of the ERK1\/2-p90RSK and NHE-1 in adult cardiomyocytes.","palabras_clave":"ENDOTHELIN|HYPERTROPHY|TRANSACTIVATION |EGFR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38786,"idioma_id":5,"titulo":"Paisajes rituales incaicos. Una mirada desde las crónicas coloniales","resumen":"El impacto de las políticas expansivas incaicas en el noroeste argentino ha sido tradicionalmente evaluado atendiendo al potencial de explotación económica de las zonas anexadas al imperio. En consonancia con esta perspectiva, la aplicación y testeo de modelos de desarrollo y expansión imperial resultaron una guía útil para predecir y explicar el correlato material de una expansión de carácter político y económico. Sin embargo, los aspectos ideológicos y simbólicos fueron históricamente menospreciados. En este artículo tomaremos en consideración las crónicas coloniales para exponer aspectos de la cosmovisión andina y destacar la importancia de su integración a las investigaciones arqueológicas.","palabras_clave":"EXPANSION INCA|NOA|CRONICAS|IDEOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38787,"idioma_id":4,"titulo":"Effects of glyphosate on egg incubation, larvae hatching and ovarian re-maturation, in the estuarine crab Neohelice granulata","resumen":"Ovigerous females of the estuarine crab Neohelice granulata were exposed to both pure glyphosate (2.5 and 5&#8201;mg\/L) and a glyphosate formulation (Roundup Ultramax, containing glyphosate at 2.5&#8201;mg\/L acid equivalent). At the end of the egg incubation period, a significant reduction in the number of hatched larvae was seen due to Roundup exposure. Additionally, several larvae abnormalities were seen in both pure glyphosate (2.5&#8201;mg\/L) and Roundup treatments, such as hydropsy and hypopigmented eyes, while atrophied eyes were also observed in the Roundup treatment. In order to evaluate the effect of the herbicide on ovarian re-maturation, females remained exposed for 32 d. Pure glyphosate at 2.5&#8201;mg\/L stimulated ovarian maturation over control levels, mainly in terms of a higher gonadosomatic index and a higher percentage of vitellogenic oocytes. A plausible hypothesis to be tested in further experiments is that exposure to glyphosate disrupts the hormonal system controlling reproduction.","palabras_clave":"Glyphosate|Crabs|Larvae|Ovary"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38788,"idioma_id":4,"titulo":"Is  time  to  flowering  in  wheat  and  barley  influenced  by  nitrogen?:  A critical  appraisal  of  recent  published  reports","resumen":"The&nbsp; literature&nbsp; includes&nbsp; a&nbsp; number&nbsp; of&nbsp; reports,&nbsp; relating&nbsp; to&nbsp; both&nbsp; crop&nbsp; and&nbsp; non-crop&nbsp; species,&nbsp; showingconflicting&nbsp; responses&nbsp; of&nbsp; developmental&nbsp; plasticity&nbsp; to&nbsp; nitrogen&nbsp; availability.&nbsp; We&nbsp; reviewed&nbsp; 1130&nbsp; papers&nbsp; published&nbsp; from&nbsp; 1990&nbsp; to&nbsp; 2010&nbsp; drawn&nbsp; from&nbsp; 14&nbsp; agriculture-themed&nbsp; journals&nbsp; and&nbsp; conducted&nbsp; a&nbsp; critical&nbsp; appraisal&nbsp; ofthe&nbsp; effects&nbsp; of&nbsp; fertiliser&nbsp; nitrogen&nbsp; on&nbsp; time&nbsp; to&nbsp; heading&nbsp; or&nbsp; anthesis&nbsp; in&nbsp; barley&nbsp; and&nbsp; wheat,&nbsp; species&nbsp; for&nbsp; which&nbsp; thereis&nbsp; a&nbsp; good&nbsp; deal&nbsp; of&nbsp; data.&nbsp; Features&nbsp; of&nbsp; the&nbsp; analysis&nbsp; were&nbsp; the&nbsp; use&nbsp; of&nbsp; relative&nbsp; responses&nbsp; (respect&nbsp; to&nbsp; unfertilisedcontrols)&nbsp; of&nbsp; yield&nbsp; and&nbsp; time&nbsp; to&nbsp; flowering&nbsp; to&nbsp; nitrogen&nbsp; as&nbsp; a&nbsp; proxy&nbsp; for&nbsp; crop&nbsp; nitrogen&nbsp; status&nbsp; and&nbsp; developmentaldifferences,&nbsp; respectively,&nbsp; and&nbsp; the&nbsp; standardisation&nbsp; of&nbsp; the&nbsp; start&nbsp; point&nbsp; for&nbsp; calculating&nbsp; time&nbsp; (in&nbsp; both&nbsp; calendarand&nbsp; thermal&nbsp; units)&nbsp; to&nbsp; flowering&nbsp; in&nbsp; autumn-sown&nbsp; winter&nbsp; cultivars&nbsp; to&nbsp; March&nbsp; 1&nbsp; (N&nbsp; Hemisphere).&nbsp; The&nbsp; resulting&nbsp; database&nbsp; (180&nbsp; cases)&nbsp; covered&nbsp; a&nbsp; broad&nbsp; range&nbsp; of&nbsp; unfertilised&nbsp; crop&nbsp; yields&nbsp; (1?8&nbsp; Mg&nbsp; ha&#8722;1),&nbsp; and&nbsp; times&nbsp; toflowering&nbsp; (47?168&nbsp; days).&nbsp; In&nbsp; very&nbsp; few&nbsp; cases&nbsp; (19&nbsp; out&nbsp; of&nbsp; 118),&nbsp; the&nbsp; relative&nbsp; time&nbsp; to&nbsp; flowering&nbsp; in&nbsp; fertilised&nbsp; cropsdiffered&nbsp; by&nbsp; more&nbsp; than&nbsp; 5%&nbsp; from&nbsp; those&nbsp; of&nbsp; unfertilised&nbsp; crops&nbsp; across&nbsp; a&nbsp; range&nbsp; of&nbsp; yield&nbsp; responses&nbsp; to&nbsp; fertilisernitrogen&nbsp; from&nbsp; negligible&nbsp; to&nbsp; three-fold.&nbsp; Currently&nbsp; available&nbsp; evidence&nbsp; does&nbsp; not&nbsp; provide&nbsp; solid&nbsp; support&nbsp; to&nbsp; aplastic&nbsp; response&nbsp; of&nbsp; time&nbsp; to&nbsp; flowering&nbsp; to&nbsp; nitrogen&nbsp; in&nbsp; these&nbsp; two&nbsp; species.","palabras_clave":"TRITICUM AESTIVUM|TRITICUM DURUM|HORDEUM VULGARE|DEVELOPMENTAL PLASTICITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38789,"idioma_id":4,"titulo":"Responses  to  temperature  of  fruit  dry  weight,  oil  concentration,  and oil  fatty  acid  composition  in  olive  (Olea  europaea  L.  var.  ?Arauco?)","resumen":"Correlative studies in olive using data from different locations or years suggest that temperature canmodulate crop oil yield and oil composition. However, there are no published studies of manipulativeexperiments that demonstrate a direct role for temperature as a regulator of oil yield and oil qualityin olive. The objectives of this study were to: i) elucidate the effect of temperature during the fruitoil accumulation phase on fruit dry weight, oil concentration and fatty acid composition; and ii) iden-tify the developmental window within the oil accumulation phase exhibiting the greatest sensitivity totemperature and that with the highest fruit capacity to recover from the temperature treatments. Twobranch-level experiments were conducted in a commercial orchard at Los Molinos (La Rioja, Argentina)using var. ?Arauco?. Both experiments were conducted during the oil accumulation phase by enclos-ing fruiting branches in transparent plastic chambers with individualized temperature control. The firstexperiment; known as the four month long experiment, employed four temperature treatments that wereapplied for a single period of four months: a control at ambient temperature, two heating levels (5&#9702;C and10&#9702;C warmer than the control), and a cooling level (5&#9702;C cooler than the control). The second experimentconsisted of four separate successive one month long treatment periods, in each of which two tempera-ture treatments were applied: control and heating (ca. 7&#9702;C higher than control). In the four month longexperiment, fruit dry weight was not affected by average temperatures in the 16?25&#9702;C range, but it wasreduced with further increases in temperature. Oil concentration decreased linearly at 1.1%&#9702;C&#8722;1acrossthe whole range (16?32&#9702;C) of average seasonal temperatures explored, while oleic acid concentrationdecreased 0.7%&#9702;C&#8722;1over the same range. In the one month long experiment, 30 days of temperaturesca. 7&#9702;C above ambient had a permanent negative effect on oil concentration at final harvest, particularlywhen the exposure to high temperature took place at the beginning of oil accumulation. By contrast,oleic acid concentration at the end of the treatment interval fell with increasing temperature but it couldrecover after treatment was removed in all periods except the first one. These results show that hightemperatures during the oil accumulation phase may negatively affect olive oil yield and quality in warmregions, particularly if the high-temperature event occurs early in the phase. Additionally, the response ofoleic acid concentration (%) to temperature under our experimental conditions was found to be oppositeto that of many annual oil-seed crops.","palabras_clave":"FATTY ACID COMPOSITION|HEATING|OLIVE OIL|OLEIC ACID CONCENTRATION|TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38790,"idioma_id":4,"titulo":"Root lodging tolerance in Helianthus annuus (L.): associations with morphological and mechanical attributes of roots","resumen":"The objectives of this study wereto quantify the morphological and mechanical propertiesof the root-plate within two sunflower hybrids ofcontrasting susceptibility to root lodging; and to evaluatethe effects of crop population density on these propertiesat two different development stages.Methods Two hybrids (CF29: tolerant, Zenit: sensitive)were grown at three densities: 5.6, 10 and 16 plantsm&#8722;2.At R2 (early reproductive) and R6 (end anthesis) developmentstages, plants were artificially lodged and stembiomass, total root biomass in the whole root-plate andin the 0?5 and &gt;5 cm layers of the plate, root number(three diametrical categories: 0?1, 1.1?2, &gt;2 mm), totalroot length, and root axial breakage force were assessed.Results CF29 root mass was twice that of Zenit withdifferences mainly in the top 5 cm of soil. This higherroot-plate biomass of CF29 was associated with a greaterroot number and root length compared to Zenit withinall root diameter categories. Roots of CF29 exhibitedhigher axial tension failure thresholds than those ofZenit, and these thresholds increased more sharply withroot diameter in CF29 than in Zenit.Conclusions The better anchorage and tolerance tolodging of CF29 with respect to Zenit arose from additiveactions of traits at both whole root-plate and individualroot levels. These included total root-plate rootlength, root number, root biomass and root axial breakageforce.","palabras_clave":"Crop population density|Ontogenetic stages|Root number, length|Root axial breakage force"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38791,"idioma_id":4,"titulo":"Adsorption of picloram herbicide on montmorillonite: Kinetic and equilibrium studies","resumen":"tThe kinetics of the adsorption of picloram (PCM) onto montmorillonite (Mt) was studied in situ byattenuated total reflectance Fourier-transform infrared spectra (ATR-FTIR). Pseudo-first-order, pseudo-second-order, intra-particle diffusion and mixed surface reaction intra-particle diffusion-controlledkinetic models were applied to the experimental results. The latter was the model that best representedthe experimental results. The adsorption equilibrium isotherms revealed the presence of two indepen-dent adsorption processes on different surface sites. The adsorption isotherms normalized by the surfacearea were fitted with the Langmuir and Freundlich models to obtain the respective parameters.Due to the anionic form of PCM, the adsorption onto the external clay mineral surface sites followed bythe entrance of the PCM molecule into the Mt basal space in a less energetically favorable pathway wasproposed. The interaction of PCM with montmorillonite surface sites through nitrogen of the pyridinering and carboxylic group by forming an inner sphere complex was confirmed by ATR-FTIR.","palabras_clave":"PICLORAM|HERBICIDE|MONTMORILLONITE|ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38792,"idioma_id":4,"titulo":"Early competition between the exotic herb Rumex acetosella and two native tussock grasses with different palatability and water stress tolerance.","resumen":"Semiarid grasslands in NW Patagonia (Argentina)are dominated by Festuca pallescensand Pappostipa speciosa, two native tussockgrasses that differ in water stress tolerance and in palatability to livestock.Both species regenerate in gap microsites invaded by the exotic herb Rumex acetosella. We performed agreenhouse experiment to study the effect of Rumex competition on early growth of the dominant tussock-grasses. InFebruary 2008 we used about 4-month-old seedlings to establish competitiontreatments that simulated a dry or wet summer. Competition among grasses wasalso quantified to relativize the effect of Rumexcompetition on each grass species. Rumex seedlings had a negative impact on grassseedlings, but it was not greater than that produced by anyco-dominant grass. Grass species did not differ in theirsensitivity to competition by Rumex or to water stress. In dry conditions, there was anintense underground competition between grass species, but there was no evidence of undergroundcompetition from Rumex. The low competitiveability of Rumex under water stress mayindicate that its invasive potential from a seedling stage would be limited bythe aridity of the environment. Moreover, the high bud production of Rumex seedlings suggests an early contribution to the soil bud bank, a key eco-biologic traitof this invasive species. Therefore, the estimation of the bud bank abundanceand the study of how vegetative regeneration may be interfering grass recruitmentshould be considered in future research.","palabras_clave":"FESTUCA PALLESCENS|GAPS|PAPPOSTIPA SPECIOSA (EX STIPA SPECIOSA)|SEMIARID GRASSLAND"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38793,"idioma_id":4,"titulo":"Renal Overexpression of Atrial Natriuretic Peptide and Hypoxia Inducible Factor-1&#120572; as Adaptive Response to a High Salt Diet","resumen":"In thekidney, a high salt intake favors oxidative stress and hypoxia and causes thedevelopment of fibrosis. Both atrial natriuretic peptide (ANP) and hypoxiainducible factor (HIF-1&#120572;) exert&nbsp; cytoprotective effects. We testedthe hypothesis that renal expression of ANP and HIF-1&#120572; is involved in a mechanismresponding to the oxidative stress produced in the kidneys of rats chronicallyfed a high sodiumdiet. Sprague-Dawley rats were fed with a normal salt (0.4%NaCl) (NS) or a high salt (8% NaCl) (HS) diet for 3 weeks with or without theadministration of tempol (T), an inhibitor of oxidative stress, in the drinkingwater. We measured the mean arterial pressure (MAP), glomerular filtration rate(GFR), and urinary sodium excretion (UVNa). We evaluated the expression of ANP,HIF-1&#120572;,and transforming growth factor (TGF-&#120573;1) in renal tissues by western blot andimmunohistochemistry. The animals fed a high salt diet showed increased MAP andVNa levels and enhanced renal immunostaining of ANP, HIF-1&#120572;, and TGF-&#120573;1. The administration oftempol together with the sodium overload increased the natriuresis further andprevented the elevation of blood pressure and the increased expression of ANP,TGF-&#120573;1,and HIF-1&#120572;&nbsp;&nbsp; compared to their control.Thesefindings suggest that HIF-1&#120572; and ANP, synthesized bythe kidney, are involved in an adaptive mechanism in response to a sodiumoverload to prevent or attenuate the deleterious effects of the oxidativestress and the hypoxia on the development of fibrosis.","palabras_clave":"HYPOXIA|ATRIAL NATRIURETIC PEPTIDE|SALT|FIBROSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38794,"idioma_id":5,"titulo":"La educación secundaria obligatoria en Argentina: entre la expansión del modelo tradicional y las alternativas de baja escala","resumen":"La extensión de la obligatoriedad escolar en Argentina afronta las limitaciones que supone incorporar nuevos sectores a la escuela secundaria sobre la base de la expansión de un modelo institucional que ha presentado pocas variantes para generar condiciones suficientes para la retención. Este trabajo reflexiona sobre las condiciones de escolarización que ofrecen dos tipos de experiencias.  Por un lado, tres iniciativas que plantean modificaciones en el modelo organizacional y régimen académico de la escuela secundaria tradicional, las que, dado el carácter intensivo de sus innovaciones, logran cierto impacto favorable en la población destinataria, aunque en pequeña escala en relación al problema que pretenden atender.   Por otro lado, una política de escala nacional y dirigida a todas las escuelas secundarias del país, que se presenta con la potencialidad de resolver algunos problemas históricos del nivel pero encuentra dificultades propias de la implementación a gran escala, debido a las configuraciones particulares que adquiere en cada una de las instituciones y a los obstáculos que el modelo organizacional del nivel impone en su desarrollo.","palabras_clave":"escuela secundaria|obligatoriedad escolar|condiciones de escolarización"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38795,"idioma_id":4,"titulo":"The Lateral Line System in Anuran Tadpoles: Neuromasts Morphology, Arrangement and Innervation","resumen":"Anuran larvae have been classified into four morphological types which reflect intraordinal macroevolution. At present, complete characterizations of the lateral line system are only available for Xenopus laevis (Type I) and Discoglossus pictus (Type III). We analyzed the morphology, arrangement, and innervation of neuromasts related to the anterodorsal and anteroventral lateral line nerves in 10 anuran species representing Types I, II, and IV with the aim of interpreting the existing variation and discussing the evolution of the lateral line in anuran larvae. We found: (1) the presence of two orbital and three mandibular neuromast lines in all anuran larvae studied,(2) the ventral arrangement of mandibular neuromast lines appears to have evolved convergently in Larval Types I and II, and the lateroventral arrangement of mandibular lines of neuromasts appears to have evolved in Larval Types III and IV; (3) interspecific variation in the organization, size, and number of sensory cells per neuromasts within the lines; and (4) the supralabial extension of the angular line in Lepidobatrachus spp. and the  tentacular location of the oral neuromasts in X. laevis are concomitant with their particular morphologies. Based on the variation described we find that the lateral line system in anuran larvae seems to have been maintained without significant changes, with the exception of Lepidobatrachus spp. and Xenopus. These unique features added to other of Lepidobatrachus tadpoles are sufficient to propose a new Larval Type (V). Anat Rec, 00:000?000, 2014. VC 2014 Wiley Periodicals, Inc.","palabras_clave":"neuromast|larvae|lateral lines|Evolution"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38796,"idioma_id":4,"titulo":"The Alteration of the C-terminal Region of Human Frataxin Distorts its Structural Dynamics and Function","resumen":"Friedreich´s Ataxia (FRDA) is linked to a deficiency of frataxin (FXN), a mitochondrial protein involved in iron-sulfur cluster synthesis. FXN is a small protein with an &#945;\/&#946; fold followed by the C-terminal region (CTR) with a non periodic structure that packs against the protein core. Here, we explore the impact of the alteration of the CTR on the stability and dynamics of FXN. We analyzed several pathological and rationally designed CTR mutants using complementary spectroscopic and biophysical approaches. The pathological mutation L198R yields a global destabilization of the structure correlating with a significant and highly localized alteration of dynamics, mainly involving residues that are in contact with L198 in wild-type FXN. Variant FXN90-195--closely related to the FRDA-associated mutant FXN81-193--conserves a globular shape with a native-like structure. However, the truncation of the CTR results in an extreme alteration of global stability and protein dynamics over a vast range of timescales and encompassing regions far from the CTR, as shown by proton-water exchange rates and 15N-relaxation measurements. Increased sensitivity to proteolysis, observed in vitro for both mutants, suggests a faster degradation rate in vivo whereas the enhanced tendency to aggregate exhibited by the truncated variant may account for the loss of functional FXN, both phenomena providing an explanation as to why the alteration of the CTR causes FRDA.  These results contribute to understanding how stability and activity are linked to protein motions and they might be useful for the design of target-specific ligands to control local protein motions for stability enhancement.","palabras_clave":"MOLECULAR MOTIONS|PROTEIN STABILITY|NMR|FRIEDREICHS ATAXIA|PROTEIN FOLDING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38797,"idioma_id":5,"titulo":"La metáfora en la construcción pedagógica macrobiana: Saturnalia y Commentarii in Somnium Scipionis","resumen":"La metáfora en la construcción pedagógica macrobiana: Saturnalia y Commentarii in Somnium Scipionis    Julieta Cardigni  UBA- CONICET  jcardigni@yahoo.es          Resumen:   El presente trabajo estudia la presentación de las metáforas en los Commentarii y Saturnalia de Macrobio (s. V d. c.) considerando que se trata de un recurso didáctico que garantiza la eficacia pedagógica, ayudando a construir las nociones de conocimiento y auctoritas al mismo tiempo. Asimismo la distribución complementaria del tipo de metáforas y símiles aplicadas al sentido de la vista en los Commentarii y a los restantes en Saturnalia nos instruyen sobre una camino gradual en la adquisición del saber, que va desde lo más concreto hasta lo más abstracto.","palabras_clave":"ANTIGUEDAD TARDÍA|MACROBIO|METÁFORA|COMMENTARII Y SATURNALIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38798,"idioma_id":4,"titulo":"Evaluation of Cocktails with Recombinant Proteins of Mycobacterium bovis for a Specific Diagnosis of Bovine Tuberculosis","resumen":"The Delayed type hypersensitivity skin test (DTH) and interferon-gamma assay are used for the diagnosis of bovine tuberculosis (TBB). The specificity of these diagnoses, however, is compromised because both are based on the response against purified protein derivative of Mycobacterium bovis (PPD-B). In this study, we assessed the potential of two cocktails containing M. bovis recombinant proteins: cocktail 1 (C1): ESAT-6, CFP-10 and MPB83 and cocktail 2 (C2): ESAT-6, CFP-10, MPB83, HspX, TB10.3, and MPB70. C1, C2, and PPD-B showed similar response by DTH in M. bovis-sensitized guinea pigs. Importantly, C1 induced a lower response than PPD-B in M. avium-sensitized guinea pigs. In cattle, C1 displayed better performance than PPD-B and C2; indeed, C1 showed the least detection of animals either vaccinated or Map-infected. To optimize the composition of the cocktails, we obtained protein fractions from PPD-B and tested their immunogenicity in experimentally M. bovis-infected cattle. In one highly reactive fraction, seven proteins were identified. The inclusion of FixB in C1 enhanced the recognition of M. bovis-infected cattle without compromising specificity. Our data provide a promising basis for the future development of a cocktail for TBB detection without interference by the presence of sensitized or infected animals with other mycobacteria.","palabras_clave":"PPDB|Tuberculosis bovina|IFN-gamma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38799,"idioma_id":5,"titulo":"Detección  de  daño  del  coleóptero Amblycerus  longesuturalis  para  la  selección  y  germinación  in  vitro  de  semillas  de Peteribí  (Cordia  trichótoma  [Vell.]  Arrab.  ex  Steudel)","resumen":"La presente investigación tuvo como objetivo establecer un método efectivo para detectar los daños producidos por el ataque de un coleóptero (Amblycerus longesuturalis) en los frutos completamente desarrollados de Cordia trichótoma, que permita seleccionar semillas sanas y\/o dañadas para la obtención de plantas. Se hallaron dos métodos efectivos para dicha selección; por un lado el uso de imágenes radiográficas como técnica no destructiva y rápida para el cultivo de frutos con pericarpio y por otro, la técnica de escisión de frutos para clasificar distintos niveles de daño en aquellos desprovistos de pericarpio. Los frutos con semillas sanas o con daño leve, fueron sometidos a tratamientos escarificatorios y saneantes con peróxido de hidrógeno (H2O2) e hipoclorito de sodio (NaOCl) para posteriormente, ser germinados in vitro. Si bien, es posible inducir germinación a partir del cultivo in vitro del fruto, la remoción del pericarpio promueve el proceso y mejora los indicadores de vigor evaluados. Los mejores resultados se obtuvieron cuando los frutos fueron sometidos a una inmersión en solución acuosa de H2O2 50% durante 3 días, luego transferidos a una solución de NaOCl 2,5% con posterior rescate y cultivo de las semillas; donde el 93,3±6,7% de las mismas germinaron, requiriendo 1,7±0,6 días de incubación para lograrlo, alcanzándose un tiempo medio de germinación (TMG) a los 5,6±0,1 días. La combinación de ambos saneantes permite obtener una óptima desinfección de las semillas para su establecimiento in vitro.","palabras_clave":"AMBLYCERUS LONGESUTURALIS|CORDIA TRICHÓTOMA |GERMINACIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38800,"idioma_id":4,"titulo":"Microplate assay for endo-polygalacturonase activity determination based on ruthenium red method","resumen":"Endo-polygalacturonase (endo-PGase) activity determinations generally rely on viscosity changes or reducing sugar ends produced by this activity over polygalacturonic acid. Torres and coworkers [Enzyme Microb. Technol. 48 (2011) 123?128] showed that ruthenium red (RR) is useful for endo-PGase determination. In this article, we present a high-throughput liquid-based endo-PGase assay based on the RR method and compare it with the viscosity determination method. The reduced assay uses a small volume of enzyme solution, 40 &#956;g of polygalacturonic acid, and 45 &#956;g of RR for each sample determination. Furthermore, we obtained an interconversion factor for RR and viscosity activities.","palabras_clave":"Microplate|Pectinases|Endo-polygalacturonases|Ruthenium red|High throughput|Assay"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38801,"idioma_id":4,"titulo":"Effects of bacterial inoculants in milk on the performance of intensively reared calves","resumen":"The aim of this study was to evaluate the effects of probiotics on the feed intake, bodyweight gain (BWG), feed efficiency (FE) and fecal microbiota of intensively reared calves fed milk inoculated with probiotic bacteria in a computerized milk feeder system. Thirty Holstein calves were allocated into three groups: group A, supplemented with an inoculum comprising Lactobacillus casei DSPV 318T, Lactobacillus salivarius DSPV 315T and Pediococcus acidilactici DSPV 006T; group B, supplemented with an inoculum comprising Lactobacillus plantarum DSPV 354T; and group C, control without probiotics. The calves were examined for 21 days. Inocula were added to the tank milk, and the daily dose for each calf was approximately 10 log CFU. The total Lactobacillus, inoculum strains, coliforms, yeast and enterococci in the stool and the total Lactobacillus, inoculum strains and pH in the tank milk were determined weekly. The lactic acid bacteria (LAB) in groups A and B produced enough acid to bring the milk to a pH lower (P < 0.05) than that of the control milk. Fermentation increased the shelf life of the milk, thereby avoiding the need to frequently discard the milk and reducing the costs for the use of the computerized milk feeder system. The probiotics-stimulated milk intake (P < 0.05) was compared with that of the control group. L. casei DSPV318T, L. salivarius DSPV 315T, P. acidilactici DSPV 006T and L. plantarum DSPV 354T were present in the gastrointestinal tracts of the calves in the probiotics groups. In addition, the Lactobacillus\/coliform ratio was greater than 1 in the probiotics groups and lower than 1 in the control group. BWG and FE were higher for group B than for group C. The presence of L. plantarum DSPV 354T and its dominance over coliforms in the fecal microbiota might have positive effects on the growth performance of calves.","palabras_clave":"bacterial inoculants|milk|calves"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38802,"idioma_id":4,"titulo":"Synthesis, Crystal structure, Spectroscopic, Thermogravimetric and Theoretical Characterization of Ni(II) and Zn(II) complexes with 4-chloro-2- nitrobenzenesulfonamide.","resumen":"Two new complexes of Ni and Zn with 4-chloro-2-nitrobenzenesulfonamide (ClNbsa) have been synthesized and characterized...","palabras_clave":"4-chloro-2-nitrobenzenesulfonamide|Ni(II) and Zn(II) complexes|Spectroscopic properties|X-Ray structure"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38804,"idioma_id":4,"titulo":"Effect of calcium hydroxide pastes and vehicles on root canal dentin microhardness","resumen":"Background: Calcium hydroxide pastes used in the endodontic therapy may produce changes in the physical properties of the dentin. Objective: The purpose of this study was to evaluate the effect of calcium hydroxide pastes and their vehicles on microhardness of root canal dentin. Materials and Methods: Sixty maxillary anterior teeth were used. The crowns of the teeth were removed at the cemento-enamel junction. Canals were instrumented, horizontally sectioned into 2 segments, embedded in acrylic resin, and polished. A total of 120 specimens were randomly divided into 12 groups. Specimens stayed in contact with the vehicles or the pastes prepared with the calcium hydroxide powder and the same vehicles. The vehicles are: Distilled water, chlorhexidine, carticaine in the anesthetic solution, propylene glycol, monochlorophenol and monochlorophenol - propylene glycol. The references Vickers microhardness were obtained prior the application of the medicaments. Samples were then exposed to the medicaments for 3, 7, and 14 days, and microhardness measured again. The results were statistically analyzed by one-way ANOVA, Tukey test, and regression. Results: All vehicles and pastes, except distilled water, signi&#64257; cantly decreased the microhardness of the root dentin; however, calcium hydroxide + camphorated monochlorophenol - propylene glycol and camphorated monochlorophenol - propylene glycol showed the highest decrease. Conclusion: Vehicles contribute to calcium hydroxide reduction of root canal dentin microhardness as constituent of endodontic pastes.","palabras_clave":"CALCIUM HYDROXIDE PASTES|CALCIUM HYDROXIDE VEHICLES|DENTINE MICROHARDNESS|ROOT CANAL DENTINE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38805,"idioma_id":4,"titulo":"Nonadiabatic excited-state molecular dynamics: Modeling photophysics in organic conjugated materials","resumen":"To design functional photoactive materials for a variety of technological applications, researchers need to understand their electronic properties in detail and have ways to control their photoinduced pathways. When excited by photons of light, organic conjugated materials (OCMs) show dynamics that are often characterized by large nonadiabatic(NA) couplings between multiple excited states through a breakdown of the Born&#8722;Oppenheimer (BO) approximation. Following photoexcitation, various nonradiative intraband relaxation pathways can lead to a number of complex processes. Therefore, computational simulation of nonadiabatic molecular dynamics is an indispensable tool for understanding complex photoinduced processes such as internal conversion, energy transfer, charge separation, and spatial localization of excitons.Over the years, we have developed a nonadiabatic excited-state molecular dynamics (NA-ESMD) framework that efficiently and accurately describes photoinduced phenomena in extended conjugated molecular systems. We use the fewest-switches surface hopping (FSSH) algorithm to treat quantum transitions among multiple adiabatic excited state potential energy surfaces (PESs). Extended molecular systems often contain hundreds of atoms and involve large densities of excited states that participate in the photoinduced dynamics. We can achieve an accurate description of the multiple excited states using the configuration interaction single (CIS) formalism with a semiempirical model Hamiltonian. Analytical techniques allow the trajectory to be propagated ?on the fly? using the complete set of NA coupling terms and remove computational bottlenecks in the evaluation of excited-state gradients and NA couplings. Furthermore, the use of state-specific gradients for propagation of nuclei on the native excited-state PES eliminates the need for simplifications such as the classical path approximation (CPA), which only uses ground-state gradients. Thus, the NA-ESMD methodology offers a computationally tractableroute for simulating hundreds of atoms on &#8764;10 ps time scales where multiple coupled excited states are involved.In this Account, we review recent developments in the NA-ESMD modeling of photoinduced dynamics in extended conjugated molecules involving multiple coupled electronic states. We have successfully applied the outlined NA-ESMD framework to study ultrafast conformational planarization in polyfluorenes where the rate of torsional relaxation can be controlled based on the initial excitation. With the addition of the state reassignment algorithm to identify instances of unavoided crossings between noninteracting PESs, NA-ESMD can now be used to study systems in which these so-called trivial unavoided crossings are expected to predominate. We employ this technique to analyze the energy transfer between poly(phenylene vinylene) (PPV) segments where conformational fluctuations give rise to numerous instances of unavoided crossings leading to multiple pathways and complex energy transfer dynamics that cannot be described using a simple Fo&#776;rster model. In addition, we have investigated the mechanism of ultrafast unidirectional energy transfer in dendrimers composed of poly(phenylene ethynylene) (PPE) chromophores and have demonstrated that differential nuclear motion favors downhill energy transfer in dendrimers. The use of native excited-state gradients allows us to observe this feature.","palabras_clave":"Excited states|nonadiabatic molecular dynamics|conjugated molecules"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38806,"idioma_id":5,"titulo":"Lagartijas de la provincia de Santa Cruz (Argentina): distribución geográfica, diversidad genética y estado de conservación","resumen":"Este trabajo resume las características geográficas, genéticas y de conservación de los saurios de la provincia de Santa Cruz; se presentan también comentarios acerca del estado de arte de la investigación en la provincia y las perspectivas futuras de los mismos. Utilizando ~ 1500 registros de presencia, se realiza un inventario biológico actualizado y se incluyen mapas de distribución, fotografías de las especies, comentarios genéticos y estatus de conservación para las lagartijas de Santa Cruz. El número de especies de lagartijas distribuidas en esta provincia es de 29 (26 especies y tres sub especies), sin embargo tres de éstas no presentan registros actuales. En base a los patrones genéticos se identifican al menos diez especies candidatas, linajes no descriptos que poseen suficiente diferenciación genética como para representar especies nuevas, cuyo estatus específico tiene que ser evaluado en futuras investigaciones. Este trabajo combina la información tradicionalmente presentada en inventarios biológicos con información genética, de distribución y estatus de conservación. Más allá de la novedosa integración realizada, este trabajo tiene la potencialidad de guiar el desarrollo de estudios detallados, en los que se puedan identificar (entre otras) zonas tanto para conservación como para explotación sustentable, así como también puede acelerar la descripción de nuevos taxa llenando los vacíos en el conocimiento de la taxonomía alfa.","palabras_clave":"INVENTARIO|LIOLAEMINI|PATAGONICA|PATRONES GENETICOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38807,"idioma_id":5,"titulo":"Depredación de Homonota darwinii Laurent 1984 (Squamata: Phyllodactylidae) por Brothriurus burmeisteri Kraepelin, 1894 (Scorpiones: Bothriuridae) en la Provincia del Chubut, Argentina","resumen":"Se presenta el primer registro documentado sobre la depredación de Homonota darwinii por un escorpión (Bothriurus burmeisteri) y proporciona información biológica adicional sobre este tipo de interacción trófica.","palabras_clave":"Homonota darwinii|Brothriurus burmeisteri |Depredación|Chubut|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38808,"idioma_id":5,"titulo":"?Una Primera Persona Que Es Colectiva Y Subalterna: La Importancia de las Epistemologías Feministas y Los estudios Postcoloniales para Pensar la Investigación Social.","resumen":"En el presente artículo, problematizo la posición del sujeto que investiga a través de la epistemología feminista y de los estudios postcoloniales, considerando que estas epistemologías y teorías, se apartan del sesgo androcéntrico del conocimiento dominante y cuestionan la hegemonía del hombre blanco, propietario y heterosexual en el saber científico. En ese sentido, reflexiono: en un primer momento, sobre el conocimiento que en este contexto se produce acerca de los sectores subalternos y sus potencialidades emancipadoras; para luego, coincidiendo con estas miradas, destacar la necesidad de vigilar constantemente la posición epistemológica-política en la investigación y en la urgencia de abandonar la ?tercera persona? de los discursos científicos.","palabras_clave":"EPISTEMOLOGÍAS FEMINISTAS|ESTUDIOS POSCOLONIALES|INVESTIGACIÓN|SECTORES SUBALTERNOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38809,"idioma_id":4,"titulo":"Cyclic behavior of a superferritic stainless steel at room and intermediate temperatures","resumen":"This paper studies the fatigue behavior at room and intermediate temperatures of a superferritic stainless  steel UNS S 44600 that had received different heat treatments. Thermal treatments at high temperature  followed by water quenching produces needle-like Cr2N precipitates that detrimentally affect the fatigue  life of superferritic stainless steels. At intermediate temperatures, independent of previous thermal treatments,  the occurrence of dynamic strain aging was manifested by a pronounced cyclic hardening rate,  inverse dependence of the peak tensile stress with strain rate, a high dislocation density and modified  dislocation arrangements. Cycling at intermediate temperature demodulates the spinodal decomposition  with a fast velocity, improving the fatigue life of aged samples.","palabras_clave":"Superferritic stainless steel|LCF|Spinodal decomposition|DSA|Precipitates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38810,"idioma_id":5,"titulo":"Hornos, minerales y escorias: una aproximación a la metalurgia extractiva en la Puna de Jujuy en época prehispánica y colonial.","resumen":"Se presentan los resultados de los análisis arqueométricos realizados sobre escorias recuperadas en seis sitios arqueológicos de la Puna de Jujuy (Argentina), uno probablemente de época prehispánica tardía y los otros cinco de época colonial. Las escorias se observaron y analizaron con técnicas de microscopía óptica, electrónica y de microanálisis químico. Estos resultados, en conjunto con la información contextual y el estudio de las evidencias de hornos conservados en los sitios, apuntaron a conocer la naturaleza de la carga mineral y las condiciones de los procesos metalúrgicos llevados a cabo en cada uno de los sitios. En líneas generales, los resultados obtenidos permiten plantear que en todos los casos se desarrolló la metalurgia extractiva de sulfuros de plomo con contenidos de plata (galena argentífera), con el objetivo de obtener este último metal. Es interesante señalar que hasta el momento no se han identificado diferencias destacadas entre los desechos de fundición producidos por el beneficio en hornos de reverbero y otro tipo de hornos, ni entre la producción colonial y la probablemente prehispánica.","palabras_clave":"HORNOS DE FUNDICIÓN|ESCORIAS|MINERALES|ARQUEOMETALURGIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38811,"idioma_id":4,"titulo":"Knowing the enemy: ant behavior and control in a pediatric hospital of Buenos Aires","resumen":"Ant control is difficult in systems where a variety of control strategies and compounds are allowed; in sensitive places such as hospitals, where there are often restrictions on the methods and toxicants to be applied, the challenge is even greater. Here we report the methods and results of how we faced this challenge of controlling ants in a pediatric hospital using baits. Our strategy was based on identifying the species present and analyzing their behavior. On the one hand, we evaluated outdoors in the green areas of the hospital, the relative abundance of ant genera, their food preferences and the behavioral dominances. On the other hand, control treatments were performed using separately two boron compounds added to sucrose solution which was not high concentrated to avoid constrains due to the viscosity. Most of the species detected in the food preference test accepted sugary food; only one species was recorded to visit it less than the protein foods. This result was consistent with the efficacy of control treatments by sugary baits within the rooms. For those species that showed good acceptance of sugar solutions in the preference test outdoors, sugar bait control indoors was 100% effective. Conversely, for the only species that foraged significantly less for sugar food, the bait treatment was ineffective. This work reveals the importance of considering the behavior and feeding preferences of the species to be controlled by toxic baits.","palabras_clave":"ANT|CHEMICAL CONTROL|BAITS|FOOD PREFERENCES|NYLANDERIA FULVA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38812,"idioma_id":4,"titulo":"Human Y- chromosome SNP characterization by multiplex  amplified product-length polymorphism analysis.","resumen":"We designed an allele-specific amplification protocol to optimize Y-chromosome SNP typing, which is an unavoidable step for defining the phylogenetic status of paternal lineages. It allows the simultaneous highly specific definition of up to six mutations in a single reaction by amplification fragment length polymorphism (AFLP) without the need of specialized equipment, at a considerably lower cost than that based on single-base primer extension (SNaPshotTM) technology or PCR-RFLP systems, requiring as little as 0.5 ng DNA and compatible with the small fragments characteristic of low-quality DNA. By designation of two primers recognizing the derived and ancestral state for each SNP, which can be differentiated by size by the addition of a noncomplementary nucleotide tail,we could define major Y clades E, F, K, R, Q, and subhaplogroups R1, R1a, R1b, R1b1b,R1b1c, J1, J2, G1, G2, I1, Q1a3, and Q1a3a1 through amplification  fragments that ranged between 60 and 158bp.","palabras_clave":"Amplification fragment length polymorphism|Single nucleotide polymorphism|South America|Y chromosome"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38813,"idioma_id":4,"titulo":"Revalidation of Chusquea argentina (Poaceae, Bambusoideae, Bambuseae) on the basis of morphological, anatomical and phenological characters","resumen":"Chusquea (Poaceae, Bambusoideae, Bambuseae) is the most diverse genus of woody bamboos in the world. In Andean Patagonian forests of southern Argentina and Chile, several species of Chusquea are the dominant components of the understory. Chusquea argentina and C. culeou fo. longiramea were described from that area on the basis of morphological characters. Some authors have considered C. argentina to be a valid species and others have treated this and C. culeou fo. longiramea as synonyms of C. culeou. This study contributes to the delimitation of these taxa. Based on morphology and anatomy, we clarify differential characters between C. culeou and C. argentina and restore the latter as a valid species. Chusquea culeou fo. longiramea is synonymized under C. argentina. According to data of mass flowering events recorded in southern Argentina and Chile, C. culeou and C. argentina become reproductive at different times. Anatomical descriptions of culm and foliage leaf blade epidermis and cross sections are provided for each species. Comparative tables based on diagnostic characters are also included.","palabras_clave":"Anatomy|Argentina|Chile|Chusquea"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38814,"idioma_id":4,"titulo":"Effect of maternal separation and chronic stress on hippocampal-dependent memory in young adult rats: evidence for the match-mismatch hypothesis","resumen":"Adverse experiences early in life may sensitize the hippocampus to subsequent stressors throughout the individual´s life. We analyzed in male rats, whether, the interaction between early maternal separation and chronic stress affects 1) the volume of the dorsal hippocampus; 2) CA1, CA2\/3 and dentate gyrus (DG); and 3) hippocampal dependent memory in adulthood. Male Wistar rats were subjected to daily maternal separation for 4.5 h between postnatal days 1-21. From postnatal day 50, animals were exposed to a chronic unpredictable stress paradigm during 24 days. The volumes of the dorsal hippocampus, their areas or strata did not reveal significant differences between treatments. Non-maternally separated and stressed animals showed poor hippocampal performance in a contextual fear conditioning test, with a significant reduction in freezing behavior during postconditioning compared with control and maternally separated and stressed animals. Also, memory retrieval 24 hours after conditioning was significantly weaker in this group than in control animals. Memory performance in maternally separated and stressed rats was similar to control animals. Our results show an interaction between early environment experiences and chronic variable stress in young adulthood as evidence that early stressful experiences do not necessarily lead to a negative outcome but can help in maintaining brain plasticity and increase fitness when animals reach adulthood.","palabras_clave":"STRESS|MEMORY|HIPPOCAMPUS|MATCH-MISMATCH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38815,"idioma_id":4,"titulo":"Modeling of the influence of light quality on the growth of microalgae in a laboratory scale photo-bio-reactor irradiated by arrangements of blue and red LEDs","resumen":"Research on microalgae has grown significantly over the past few decades, due to their multiple uses and applications. The distribution of the density of radiant energy within the photo-bio-reactor and its impact on the growth of microalgae through the local rate of absorption of radiant   energy is essential for the analysis, modeling and design of a photo-bio-reactor because of the light stratification inside a microalgal culture.   In this work we develop a physical model and a computer simulation algorithm, in order to accurately predict the rate of absorption of photons in microalgal cultures at each point of a photo-bio-reactor   irradiated with a light source made of different arrangements of LEDs emitting in blue and red spectral regions. Results showed that the average absorption rates in the culture irradiated with blue LEDs   were higher than that irradiated with red LEDs. However, the radiation emitted by red LEDs rendered greater energy efficiency for biomass production compared to that emitted by blue LEDs. This facts are   analyzed through the photon capture mechanism of microalgal antenna complex and photosystem interaction.","palabras_clave":"Microalgae|Modeling|Bioreactors|Light Emitting Diode|Monte Carlo|Scale Up"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38816,"idioma_id":4,"titulo":"Contrasting patterns of MAAs accumulation in two populations of the copepod Boeckella gracilipes","resumen":"The bio-accumulation of mycosporine-like amino acids (MAAs) is common in planktonic copepods that inhabit environments exposed to high levels of solar radiation. MAAs accumulation in copepods can be affected both by extrinsic (environmental) and intrinsic factors (local adaptation, genotype, etc.). Laboratory experiments were performed to study the bio-accumulation of MAAs in two geographically-isolated populations of Boeckella gracilipes from a mountain and a piedmont lake of North Patagonia. We performed two series of 10-day incubations of B. gracilipes from the different lakes applying two radiation conditions (PAR + UVR and darkness), at five different temperatures (5 to 20 °C) and providing a MAA-free flagellate as food. We assumed that differences in final MAAs concentrations between copepod populations should be exclusively due to environmental factors, and that any difference in the patterns of MAAs accumulation should exclusively arise from differences in MAAs concentration at the time of collection. MAAs concentration was three fold higher in B. gracilipes from Lake Verde than in copepods from the Lake Morenito. The MAAs suite was dominated (&#8764;90%) by a combination of porphyra-334 and mycosporine-glycine in copepods from Lake Verde, and porphyra-334 and MAA-332 in those from Lake Morenito. Two exclusive MAA compounds were identified, mycosporine-glycine in copepods from Lake Verde and shinorine in the copepod population from Lake Morenito. Laboratory experiments showed that: (i) exposure to PAR + UVR stimulated the accumulation of MAAs in both copepod populations; (ii) temperature affected the response of MAAs and, remarkably, low temperatures stimulated MAAs accumulation even in dark incubations, (iii) the response to radiation and temperature in MAAs accumulation was more pronounced in the population with low initial MAAs than in the population with high initial MAAs concentrations. The differences in intrinsic factors between B. gracilipes populations, such as local adaptation to contrasting UV and temperature scenarios, among others, appear to play an important role in determining levels and patterns of MAAs accumulation in B. gracilipes.","palabras_clave":"Bioaccumulation|MAAs|Boeckella gracilipes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38817,"idioma_id":4,"titulo":"Second-  and  higher-order  data  generation  and  calibration:  A  tutorial","resumen":"An introduction to multi-way calibration based on second- and higher-order data generation and processing is provided, with emphasis on practical experimental aspects. After a discussion concerning a proper nomenclature scheme, a suitable classification of the obtainable data, and the general features of the available algorithms and their underlying models, a series of examples is discussed in detail, with the purpose of illustrating the great potentiality of the field for the analytical community. Emphasis is directed toward the most popular multi-way data, i.e., second-order or matrix data, which can be conveniently measured in a variety of instruments. Third-order data are being increasingly studied and arealso discussed, along with the less explored field of fourth-order data. The estimation of figures of merit, which analysts need to report during method development, is now sufficiently mature to be provided for the general audience.","palabras_clave":"MULTIWAY-CALIBRATION|PARALLEL FACTOR ANALYSIS|MULTIVARIATE CURVE RESOLUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38818,"idioma_id":4,"titulo":"Ultra fast quantitation of six quinolones in water samples by second order capillary electrophoresis data modeling with multivariate curve resolution?alternating least squares","resumen":"This paper presents the development of a capillary electrophoresis method with diode array detector coupled to multivariate curve resolution alternating least squares (MCR-ALS)to conduct the resolution and quantitation of a mixture of six quinolones in the presence of several unexpected components. Overlapping of time profiles between analytes and  water matrix interferences were mathematically solved by data modeling with the well-known MCR-ALS algorithm. With the aim of overcoming the drawback originated by two compounds with similar spectra, a special strategy was implemented to model the complete electropherogram instead of dividing the data in the region as usually performed in previous works. The method was first applied to quantitate analytes in standard mixtures which were randomly prepared in ultrapure water. Then, tap water samples spiked with several interferences were analyzed. Recoveries between 76.7 and 125 % and limits of detection between 5 and 18 &#956;g\/L were achieved.","palabras_clave":"Capillary electrophoresis|Chemometrics|Water"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38819,"idioma_id":4,"titulo":"PROTECTION OF GALVANIZED STEEL WITH SILANES: ITS COMPARISON WITH CHROMIUM (VI).","resumen":"The corrosion behavior of hot dip galvanized steel (HDGS) pre-treated with mercaptopropyltrimethoxysilane and a commercial sulfur-bearing silane was studied. Electrochemical polarization, electrochemical  impedance spectroscopy, and electrochemical noise tests showed that silane coatings have a corrosion protection performance similar to the usual hexavalent chromium HDGS passivation treatments. It is also  evident that the silane films protect the zinc surface through the formation of an isolating barrier. Through voltamperometric studies it was possible to define an electrochemical porosity of the protective coatings.  Based on copper sulfate tests and electrochemical porosity results the films protection capability was evaluated, showing that silane treatments have similar or even better protection performance than standard  chromium passivation.","palabras_clave":"VOLTAMETRY|IMPEDANCE|SILANE|GALVANIZED"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38820,"idioma_id":4,"titulo":"Dynamic Scheduling based on Particle Swarm Optimization for Cloud-based Scientific Experiments [Latindex]","resumen":"Parameter Sweep Experiments (PSEs) allow scientists to perform simulations by running the same code with different input data, which results in many CPU-intensive jobs, and hence parallel computing environments must be used. Within these, Infrastructure as a Service (IaaS) Clouds offer custom Virtual Machines (VM) that are launched in appropriate hosts available in a Cloud to handle such jobs. Then, correctly scheduling Cloud hosts is very important and thus efficient scheduling strategies to appropriately allocate VMs to physical resources must be developed. Scheduling is however challenging due to its inherent NP-completeness. We describe and evaluate a Cloud scheduler based on Particle Swarm Optimization (PSO). The main performance metrics to study are the number of Cloud users that the scheduler is able to successfully serve, and the total number of created VMs, in online (non-batch) scheduling scenarios. Besides, the number of intra-Cloud network messages sent are evaluated. Simulated experiments performedusing CloudSim and job data from real scientific problems show that our scheduler achieves better performance than schedulers based on Random assignment and Genetic Algorithms. We also study the performance when supplying or not job information to the schedulers, namely a qualitative indication of job length.","palabras_clave":"PARAMETER SWEEP EXPERIMENTS|CLOUD COMPUTING|IaaS|JOB SCHEDULING|PARTICLE SWARM OPTIMIZATION|GENETIC ALGORITHMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38821,"idioma_id":4,"titulo":"The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells","resumen":"Photodynamic Therapy (PDT) is an anticancer treatment based on photosensitisation of malignant cells. The precursor of the photosensitiser Protoporphyrin IX, 5-aminolevulinic acid (ALA), has been used for PDT of bladder cancer. Silybin is a flavonoid extracted from Silybum marianum, and it has been reported to increase the efficacy of several anticancer treatments. In the present work, we evaluated the cytotoxicity of the combination of ALA-PDT and silybin in the T24 and MB49 bladder cancer cell lines. MB49 cells were more sensitive to PDT damage, which was correlated with a higher Protoporphyrin IX production from ALA. Employing lethal light doses 50% (LD50) and 75% (LD75) and additional silybin treatment, there was a further increase of toxicity driven by PDT in both cell lines. Using the Chou-Talalay model for drug combination derived from the mass-action law principle, it was possible to identify the effect of the combination as synergic when using LD75, whilst the use of LD50 led to an additive effect on MB49 cells. On the other hand, the drug combination turned out to be nearly additive on T24 cells. Apoptotic cell death is involved both in silybin and PDT cytotoxicity in the MB49 line but there is no apparent correlation with the additive or synergic effect observed on cell viability. On the other hand, we found an enhancement of the PDT-driven impairment of cell migration on both cell lines as a consequence of silybin treatment. Overall, our results suggest that the combination of silybin and ALA-PDT would increase PDT outcome, leading to additive or synergistic effects and possibly impairing the occurrence of metastases.","palabras_clave":"SILIBINA|CANCER DE VEJIGA|APOPTOSIS|TERAPIA FOTODINAMICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38823,"idioma_id":5,"titulo":"REDES INTELIGENTES DE DISTRIBUCIÓN CON ALTA PENETRACIÓN DE VEHÍCULOS ELÉCTRICOS: DESAFÍOS Y SOLUCIONES PARA UNA OPERACIÓN EFICIENTE","resumen":"La conexión no controlada de una gran cantidad de vehículos eléctricos, puede afectar severamente el estado operativo de la red eléctrica de distribución. Estos vehículos tienen la capacidad de consumir, almacenar y suministrar energía. En este contexto, es fundamental desarrollar algoritmos y herramientas de cálculo, para despachar económicamente y de manera controlada los requerimientos impuestos por los mismos. Para facilitar esta funcionalidad, se requiere de sistemas que interactúen entre los vehículos eléctricos y los operadores de los centros de control de distribución. Una alternativa para ello es utilizar el concepto de los ?agregadores?. En este sentido, el presente trabajo describe las características y funcionalidad de los agregadores. Además, propone una estructura jerárquica de control y analiza el rol de los agregadores en el despacho económico de una red de distribución que integra una gran cantidad de vehículos.","palabras_clave":"Despacho económico|Recursos de energía dispersa|Redes inteligentes de distribución|Vehículos eléctricos|Planificación y operación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38824,"idioma_id":4,"titulo":"Use of 'One-Pot, Mix-and-Read' peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle.","resumen":"Peptide-major histocompatibility complex (p-MHC) class I tetramer complexes have facilitated the early detection and functional characterisation of epitope specific CD8+ cytotoxic T lymphocytes (CTL). Here, we report on the generation of seven recombinant bovine leukocyte antigens (BoLA) and recombinant bovine &#946;2-microglobulin from which p-MHC class I tetramers can be derived in ~48 h. We validated a set of p-MHC class I tetramers against a panel of CTL lines specific to seven epitopes on five different antigens of Theileria parva, a protozoan pathogen causing the lethal bovine disease East Coast fever. One of the p-MHC class I tetramers was tested in ex vivo assays and we detected T. parva specific CTL in peripheral blood of cattle at day 15-17 post-immunization with a live parasite vaccine. The algorithm NetMHCpan predicted alternative epitope sequences for some of the T. parva CTL epitopes. Using an ELISA assay to measure peptide-BoLA monomer formation and p-MHC class I tetramers of new specificity, we demonstrate that a predicted alternative epitope Tp229-37 rather than the previously reported Tp227-37 epitope is the correct Tp2 epitope presented by BoLA-6*04101. We also verified the prediction by NetMHCpan that the Tp587-95 epitope reported as BoLA-T5 restricted can also be presented by BoLA-1*02301, a molecule similar in sequence to BoLA-T5. In addition, Tp587-95 specific bovine CTL were simultaneously stained by Tp5-BoLA-1*02301 and Tp5-BoLA-T5 tetramers suggesting that one T cell receptor can bind to two different BoLA MHC class I molecules presenting the Tp587-95 epitope and that these BoLA molecules fall into a single functional supertype.","palabras_clave":"BoLA\/MHC|CTL epitope|Tetramer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38825,"idioma_id":4,"titulo":"Reply to Skutsch et al.","resumen":"Skutsch et al. criticized the results of our recently publishedarticle, which explores the relationship between land change 3 andland tenure in Mexico (Bonilla-Moheno et al., 2013). Below we take the opportunity to explain why their 15 interpretations of our analyses are misrepresented and 16 erroneous.","palabras_clave":"land tenure|mexico|deforestation|forest transition"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38826,"idioma_id":4,"titulo":"Global and Direct UV Irradiance Variation in the Nahuel Huapi National Park (Patagonia, Argentina) After the Eruption of  Puyehue-Cordon Caulle (Chile).","resumen":"On June4th,2011,thePuyehue-CordonCaullevolcaniccomplex(40135025??S 72107002??W,Chile)started eruption, sendingash45,000feetintotheatmosphere.Aftertheinitialperiod,theeruptioncontinued for severalmonths,withlessintensity.ChangesinglobalirradianceintheUV-BandUV-A,anddirect irradiance andAODintheUV-A,asconsequenceoftheeruption,werestudied.Globalirradiancehas been permanentlymeasuredattheLaboratoryofPhotobiology(LPh)(41.13S,71.42W,804msl)since 1998.Inaddition,intheframeofaprojecttostudyaltitudeeffectondirectandglobalirradiance, field campaigns wereperformedduringSeptember17thto23rd,2010andSeptember14thto18th,2011,in the regionoftheNahuelHuapiNationalPark,near100kmfromtheeruption.Inthoseperiods, simultaneous measurementsofdirectandglobalirradianceandaerosolopticaldepth(AOD)were carried outatthreesites:LaboratoryofPhotobiology(LPh),MtOtto(41.15S,71.38W,1386msl)and Mt Catedral(41.17S,71.48W,1930msl).Theanalysisofaerosolsin2011,threetofourmonthafterthe eruption started,showedthepresenceoflargerparticlesandmorevariabilitythanin2010,atallsites. Global irradiance,atLPh,alsoexhibitedlargervariability,comparedto1999,whennoeruptionorany other eventthatcouldhaveproducedmajorchangesinaerosolsoccurred.Themeandecrease,as consequenceofthevolcanoactivity,atLPh,wasaround20%,at305nmandclosedto10%,at320nm. At 380nm,thedecreasewasverysmallandnotstatisticallysignificant, althoughinparticulardays,with large aerosolload,asignificant decreasewasobserved.Directirradiance,intheUV-A,showedlarger decrease thanglobalirradiance.Theeffectoftheeruptionwasmorepronouncedatthelowaltitudesite. 135025??S 72107002??W,Chile)started eruption, sendingash45,000feetintotheatmosphere.Aftertheinitialperiod,theeruptioncontinued for severalmonths,withlessintensity.ChangesinglobalirradianceintheUV-BandUV-A,anddirect irradiance andAODintheUV-A,asconsequenceoftheeruption,werestudied.Globalirradiancehas been permanentlymeasuredattheLaboratoryofPhotobiology(LPh)(41.13S,71.42W,804msl)since 1998.Inaddition,intheframeofaprojecttostudyaltitudeeffectondirectandglobalirradiance, field campaigns wereperformedduringSeptember17thto23rd,2010andSeptember14thto18th,2011,in the regionoftheNahuelHuapiNationalPark,near100kmfromtheeruption.Inthoseperiods, simultaneous measurementsofdirectandglobalirradianceandaerosolopticaldepth(AOD)were carried outatthreesites:LaboratoryofPhotobiology(LPh),MtOtto(41.15S,71.38W,1386msl)and Mt Catedral(41.17S,71.48W,1930msl).Theanalysisofaerosolsin2011,threetofourmonthafterthe eruption started,showedthepresenceoflargerparticlesandmorevariabilitythanin2010,atallsites. Global irradiance,atLPh,alsoexhibitedlargervariability,comparedto1999,whennoeruptionorany other eventthatcouldhaveproducedmajorchangesinaerosolsoccurred.Themeandecrease,as consequenceofthevolcanoactivity,atLPh,wasaround20%,at305nmandclosedto10%,at320nm. At 380nm,thedecreasewasverysmallandnotstatisticallysignificant, althoughinparticulardays,with large aerosolload,asignificant decreasewasobserved.Directirradiance,intheUV-A,showedlarger decrease thanglobalirradiance.Theeffectoftheeruptionwasmorepronouncedatthelowaltitudesite. ","palabras_clave":"UV radiation|volcanic eruptions"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38827,"idioma_id":4,"titulo":"Synergistic antiproliferative and anticholesterogenic effects of linalool, 1,8-cineole and  simvastatin on human cell lines.","resumen":"Abstract: Monoterpenes are naturally occurring plant hydrocarbons with multiple effects on the   mevalonate pathway (MP), while statins competitively inhibit hydroxymethylglutarylcoenzyme-A   reductase (HMGCR), the rate-limiting enzyme in the MP. Monoterpenes and statins proved capable of   inhibiting both proliferation and cholesterogenesis. In the present study we assess the in-vitro   antiproliferative and anticholesterogenic effects of two monoterpenes: linalool and 1,8-cineole?either   alone, in combination with each other, or combined individually with simvastatin?on liver-derived   (HepG2) and extrahepatic (A549) cell lines. The three compounds alone inhibited cell proliferation in a   dose-dependent fashion, while their pairwise combination produced synergistic antiproliferative   effects in both cell lines. Incorporation experiments with [14C]acetate revealed that linalool and 1,8-  cineole inhibited the MP, probably at different points, resulting in a reduction in cholesterogenesis and   an accumulation of other MP intermediates and products. Linalool or 1,8-cineole, either together or   individually with simvastatin, synergistically inhibited cholesterol synthesis. At low concentrations   both monoterpenes inhibited steps specifically involved in cholesterol synthesis, whereas at higher   concentrations HMGCR levels became down-regulated. Added exogenous mevalonate failed to reverse   the inhibition of proliferation exerted by linalool and 1,8-cineole, suggesting that HMGCR inhibition   alone is not responsible for the antiproliferative activity of those agents. This work demonstrates that   monoterpenes in combination with each other, or individually in combination with simvastatin   synergistically inhibits proliferation and cholesterogenesis in the human cell lines investigated, thus   contributing to a clearer understanding of the action of essential-oil components, and their   combination with the statins, in the targeting of specific points within a complex metabolic pathway","palabras_clave":"linalool|1,8-cineole|simvastatin|cholesterogenesis|synergistic effects|proliferation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38828,"idioma_id":4,"titulo":"Agricultural adjustment, population dynamics and forests redistribution in a subtropical watershed of NW Argentina","resumen":"Patterns of land-use and land-cover change are  usually grouped into one of two categories defined by the  dominant trend: (1) deforestation resulting from expanding  agriculture and (2) forest expansion, usually related to the  abandonment of marginal lands. At regional scale, however,  both processes can occur simultaneously even in the  absence of net change. Given the focus on net change, such  redistribution of agricultural and natural and seminatural  lands has been generally overlooked. The interaction  between agriculture modernization, human demography  and complex topographic gradients of northwestern  Argentina has resulted in processes of both forest recovery  and deforestation, thus providing the opportunity to analyze  patterns and driving forces of land-cover redistribution.  We analyzed 20 years (1986?2006) of land-cover  change in a subtropical watershed in relation to topographic  and demographic variables. Although net forest  change represented  %, forests redistribution affected  7 % of forest lands. There was a consistent geographic  segregation of deforestation and forest recovery, with forests  expanding over steep highlands and agriculture  expanding over lowland irrigated areas. Population trends  were not associated to forest expansion in lowlands but  they explained 32 % of forest recovery in highlands.  Highland forest expansion and lowland deforestation,  respectively, imply conservation opportunities for humid  montane forests and the environmental services they provide  (e.g., watershed conservation) and threats for the  conservation of dry forests and its biodiversity. Our study  exemplifies the importance of land-use redistribution  (rather than net change) with relevant environmental consequences  at regional scale.","palabras_clave":"Agriculture adjustment|Forest transition|Migration|Land use change"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38829,"idioma_id":4,"titulo":"SUPPRESSION BY GERANIOL OF THE GROWTH OF A549 HUMAN-LUNG ADENOCARCINOMA CELLS AND INHIBITION OF THE MEVALONATE PATHWAY IN CULTURE AND IN VIVO: POTENTIAL USE IN CANCER CHEMOTHERAPY","resumen":"  Geraniol (G)?a natural compound present in the essential oils of many aromatic  plants?has attracted interest for its potential antitumor effects. The molecular  mechanisms of the growth inhibition and apoptosis induced by geraniol in cancer cells,  however, remain unclear. In this study, we investigated the effects of G on cell  proliferation in culture in A549 cells and in vivo in those same tumor cells implanted in   nude mice fed diets supplemented with 25, 50, and 75 mmol G\/Kg. We demonstrated that  G caused a dose- and time-dependent growth inhibition of A549 cellsand tumor growth in   vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.      vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.      nude mice fed diets supplemented with 25, 50, and 75 mmol G\/Kg. We demonstrated that  G caused a dose- and time-dependent growth inhibition of A549 cellsand tumor growth in   vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.      vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.        nude mice fed diets supplemented with 25, 50, and 75 mmol G\/Kg. We demonstrated that  G caused a dose- and time-dependent growth inhibition of A549 cellsand tumor growth in   vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.      vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.      in vivo in those same tumor cells implanted in   nude mice fed diets supplemented with 25, 50, and 75 mmol G\/Kg. We demonstrated that  G caused a dose- and time-dependent growth inhibition of A549 cellsand tumor growth in   vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.      vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    in   vivo along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.    G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.  along with an induction of apoptosis. Moreover, further in-vivo assays indicated that   G decreased the levels of 3-hydroxymethylglutarylcoenzyme-A reductase?the ratelimiting  enzyme in cholesterogenesis?in a dose dependent manner along with  cholesterogenesis and cholesterolemia in addition to reducing the amount of membranebound  Ras protein. These results showed that the doses of G used in this work, though  nontoxic to animals, clearly inhibited the mevalonate pathway, which is closely linked to  cell proliferation and increased apoptosis in A549 tumors, but not in normal mouse-liver  cells. Accordingly, we suggest that G displays significant antitumor activity and should be  a promising candidate for cancer chemotherapy.","palabras_clave":"APOPTOSIS|ATHYMIC NUDE MICE|CASPASES|INVITRO\/CELL CULTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38830,"idioma_id":4,"titulo":"N- Nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms","resumen":"Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a two-fold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of cFOS and PER1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-hour delay). Here we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. This article is protected by copyright. All rights reserved.","palabras_clave":"N-NITROSOMELATONIN|CIRCADIAN|JET-LAG|NITRIC OXIDE|SUPRACHIASMATIC NUCLEUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38831,"idioma_id":4,"titulo":"Halogenhalogen contacts for the stabilization of a new polymorph of 9,10-dichloroanthracene","resumen":"A new polymorph of 9,10-dichloroanthracene (9,10-DCA) namely as c form, was obtained. The crystal structure of the c polymorphic system showed an orthorhombic P212121 space group with a = 3.8957(2) Å, b = 15.9383(5) Å, c = 17.3107(7) Å, a = b = c = 90°, while the other polymorphs, a and b, crystallized in P21\/a and P-1 ones, respectively. The intermolecular geometries of c form were analyzed showing that the crystalline self-assembly of this new polymorph of the 9,10-DCA is stabilized by nonclassical C?H...Cl hydrogen bonds, pi-pi stacking interactions, and mainly by Cl...Cl interactions.  Structural parameters confirmed the halogen...halogen contacts correspond to the Type II geometry. Complementary, electronic structure calculations were performed in other to estimate the energetic contribution of the observed intermolecular interactions in the crystal packing of the new system. Density Functional Theory (DFT) considering empirical dispersion corrections (named as DFT-D) and MP2 correlated very well and showed energy values according to previously reported related compounds (e.g., the energy for the Cl-Cl is -5.37 and -3.25 kcal mol-1 for MP2\/6-31+G** and B2PLYP-D\/6-31+G**, respectively). On the other hand, and as expected, DFT using B3LYP as functional was not able to describe properly the studied intermolecular interactions. Moreover, it even predicts repulsive energies for most of the analyzed arrangements.","palabras_clave":"Dichloroanthracene|Polymorphism|Molecular conformation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38832,"idioma_id":4,"titulo":"Identification of signaling pathways modulated by RHBDD2 in breast cancer cells: a link to the unfolded protein response","resumen":"Rhomboid domain containing 2 (RHBDD2) was previously observed overexpressed and amplified in breast cancer samples. In order to identify biological pathways modulated by RHBDD2, gene expression profiles of RHBDD2 silenced breast cancer cells were analyzed using whole genome human microarray. Among the statistically significant overrepresented biological processes, we found protein metabolism-with the associated ontological terms folding, ubiquitination, and proteosomal degradation-cell death, cell cycle, and oxidative phosphorylation. In addition, we performed an in silico analysis searching for RHBDD2 co-expressed genes in several human tissues. Interestingly, the functional analysis of these genes showed similar results to those obtained with the microarray data, with negative regulation of protein metabolism and oxidative phosphorylation as the most enriched gene ontology terms. These data led us to hypothesize that RHBDD2 might be involved in endoplasmic reticulum (ER) stress response. Thus, we specifically analyzed the unfolding protein response (UPR) of the ER stress process. We used a lentivirus-based approach for stable silencing of RHBDD2 mRNA in the T47D breast cancer cell line, and we examined the transcriptional consequences on UPR genes as well as the phenotypic effects on migration and proliferation processes. By employing dithiothreitol as an UPR inducer, we observed that cells with silenced RHBDD2 showed increased expression of ATF6, IRE1, PERK, CRT, BiP, ATF4, and CHOP (p&#8201;&lt;&#8201;0.01). We also observed that RHBDD2 silencing inhibited colony formation and decreased cell migration. Based on these studies, we hypothesize that RHBDD2 overexpression in breast cancer could represent an adaptive phenotype to the stressful tumor microenvironment by modulating the ER stress response","palabras_clave":"RHBDD2|UPR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38833,"idioma_id":4,"titulo":"Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c","resumen":"Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met\/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.","palabras_clave":"cytochrome c|alkaline transition|peroxidase activity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38834,"idioma_id":5,"titulo":"Tareas y espacios áulicos compartidos para la enseñanza de las prácticas  de lectura y escritura académica en el primer año universitario.","resumen":"En este artículo exponemos una experiencia de enseñanza y de aprendizaje desarrollada en las aulas del primer año de una carrera universitaria en el ámbito de las Ciencias de la Educación. Procuramos generar situaciones de clases que promovieran en los estudiantes genuinas implicaciones en experiencias de lectura y escritura académica, atendiendo especialmente a la función epistémica de esas prácticas y a la conciencia de sí mismos como lectores-escritores universitarios, a la vez que avanzar en el aprendizaje de los contenidos disciplinares propios de las asignaturas de la currícula de grado.    El diseño y la concreción de las actividades de aprendizaje que ofrecimos a los estudiantes se materializó en un contexto de trabajo colaborativo entre  docentes de distintas asignaturas. Los docentes involucrados trabajamos en la elaboración conjunta de consignas, en el establecimiento de criterios para la selección de los textos que se ofrecieron a los estudiantes y en la generación de espacios de trabajo áulico compartido.    Esta experiencia se desprende de un proyecto más amplio aprobado en el marco de la  convocatoria para la presentación de  Proyectos para la Democratización del Conocimiento  (Facultad de Ciencias Humanas - Universidad Nacional de Río Cuarto). A los fines de esta comunicación, hemos focalizado en el trabajo llevado a cabo por dos de las asignaturas involucradas en ese proyecto: una de ellas ofrece contenidos disciplinares específicos y la otra tematiza sobre la lectura y la escritura y sus vinculaciones con el aprendizaje en la universidad.    Nos interesa presentar, discutir y valorar las actividades implementadas en la experiencia: a) situaciones de lectura de textos disciplinares y de procesos de intervención profesional propios del campo al que aspiran pertenecer los estudiantes y b) situaciones de escritura que demandaron el análisis del proceso de intervención en base a los textos disciplinares que fueron objeto de lectura.","palabras_clave":"LECTURA|ESCRITURA|TAREAS COMPARTIDAS|UNIVERSIDAD|PRIMER AÑO|ENSEÑANZA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38835,"idioma_id":4,"titulo":"The role of protein dynamics and thermal fluctuations in regulating cytochrome c \/ cytochrome c oxidase electron transfer","resumen":"In this overview we present recent combined electrochemical, spectroelectrochemical, spectroscopic and computational studies from our group on the electron transfer reactions of cytochrome c and of the primary electron acceptor of cytochrome c oxidase, the CuA site, in biomimetic complexes. Based on these results, we discuss how protein dynamics and thermal fluctuations may impact on protein ET reactions, comment on the possible physiological relevance of these results, and finally propose a regulatory mechanism that may operate in the Cyt\/CcO electron transfer reaction in vivo.","palabras_clave":"electron transfer|protein dynamics|cytochrome c|cua center"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38836,"idioma_id":4,"titulo":"Control of the electronic ground state on an electron transfer copper site by second-sphere perturbations","resumen":"The CuA center is a dinuclear copper site that serves as an optimized hub for long-range electron transfer in heme-copper terminal oxidases. Its electronic structure can be described in terms of a &#963; u* ground-state wavefunction with an alternative, less populated ground state of &#960;u symmetry, which is thermally accessible. It is now shown that second-sphere mutations in the CuA containing subunit of Thermus thermophilus ba3 oxidase perturb the electronic structure, which leads to a substantial increase in the population of the &#960;u state, as shown by different spectroscopic methods. This perturbation does not affect the redox potential of the metal site, and despite an increase in the reorganization energy, it is not detrimental to the electron-transfer kinetics. The mutations were achieved by replacing the loops that are involved in protein-protein interactions with cytochrome c, suggesting that transient protein binding could also elicit ground-state switching in the oxidase, which enables alternative electron-transfer pathways. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.","palabras_clave":"Electronic structure|Alternative Ground States|CuA Sites"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38837,"idioma_id":4,"titulo":"First record of Pseudosuccinea columella (Say, 1817) from Salta province, northwest Argentina (Mollusca: Gastropoda: Lymnaeidae)","resumen":"Pseudosuccinea columella (Say, 1817) is a widely distributed freshwater snail of medical and veterinary interest  because it is the first intermediate host of Fasciola hepatica (Linnaeus, 1758). It is an invasive species in the Neotropical  region and in Argentina is known from the central and the northeast regions. Pseudosuccinea columella is reported for  the first time from Salta province, northwest Argentina. This new record, the westernmost in Argentina, suggests that P.  columella continues to increase its geographic distribution in the Neotropical region. Although P. columella is naturally  infected with F. hepatica in northeast Argentina, snails from the new location in Salta province were not found to be infected.","palabras_clave":"Mollusca|Gastropoda|Lymnaeidae"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38838,"idioma_id":4,"titulo":"Loss of Sertoli-Germ Cell Adhesion Determines the Rapid Germ Cell Elimination During the Seasonal Regression of the Seminiferous Epithelium of the Long Hairy Armadillo Chaetophractus villosus","resumen":"The armadillo Chaetophractus villosus is a seasonal breeder whose seminiferous epithelium undergoes rapid regression with massive germ cell loss, leaving the tubules with only Sertoli cells and spermatogonia. Here, we addressed the question of whether this regression entails 1) the disassembly of cell junctions (immunolocalization of nectin-3, Cadm1, N-cadherin, and beta-catenin, and transmission electron microscopy [TEM]); 2) apoptosis (immunolocalization of cytochrome c and caspase 3; TUNEL assay); and 3) the involvement of Sertoli cells in germ cell phagocytosis (TEM). We showed a dramatic reduction in the extension of vimentin filaments associated with desmosomelike junctions at the interface between Sertoli and germ cells, and an increased diffusion of the immunosignals of nectin-3, Cadm1, N- cadherin, and beta-catenin. Together, these results suggest loss of Sertoli-germ cell adhesion, which in turn might determine postmeiotic cell sloughing at the beginning of epithelium regression. Then, loss of Sertoli-germ cell adhesion triggers cell death. Cytochrome c is released from mitochondria, but although postmeiotic cells were negative for late apoptotic markers, at advanced regression spermatocytes were positive for all apoptotic markers. Transmission electron microscopy anal- ysis showed cytoplasmic engulfment of cell debris and lipid droplets within Sertoli cells, a sign of their phagocytic activity, which contributes to the elimination of the residual meiocytes still present in the latest regression phases. These findings are novel and add new players to the mechanisms of seminiferous epithelium regression occurring in seasonal breeders, and they introduce the armadillo as an interesting model for studying seasonal spermatogenesis.","palabras_clave":"adhesion molecules|anoikis|apoptosis|Cadm1|intermediate filaments|N-cadherin|b-catenin|nectin-3|phagocytosis|seasonal reproduction|spermatogenesis|testosterone"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38839,"idioma_id":5,"titulo":"CARACTERIZACIÓN DE FUENTES SISMOGÉNICAS EN EL FRENTE OROGÉNICO ACTIVO DE LOS ANDES CENTRALES A LA LATITUD DE LA CIUDAD DE MENDOZA (32º50´-33º S)","resumen":"El actual frente orogénico activo de los Andes Centrales abarca parte del piedemonte mendocino ubicado cerca de la ciudad capital donde habitan al menos 800.000 personas. A pesar de ello, se carece de un estudio integral de fallas activas de este sector como potenciales fuentes sismogénicas. El presente estudio intenta soslayar esta falencia caracterizando las principales estructuras activas e integrándolas en un modelo cinemático-estructural elaborado a partir de tres perfiles estructurales balanceados. La deformación pedemontana se caracteriza por una población de fallas compresivas de rumbo N-S a NNE-SSO, cuyo nivel de despegue se ubicaría en el basamento pre-Silúrico, constituyendo un frente emergente de piel gruesa. La serie de corrimientos imbricados con despegue ubicado a 9-10 km de profundidad corresponde a las fallas Melocotón y Divisadero Largo, que presentan expresión superficial, y a una falla ciega denominada Maure, interpretada a partir del modelo estructural. La falla ciega Maure transfiere su rechazo hacia un sistema de fallas retrovergentes de piel fina, con despegue dentro de los depósitos sinorogénicos neógenos, conformando de esta manera una zona de deformación triangular. Según los rasgos morfométricos de estos fallamientos los sismos máximos probables rondan entre magnitudes de 5.4 a 6.8 Mw. Co-existen fallas transcurrentes sinestrales de rumbo NO-SE que se encuentran cortando a las fallas retrovergentes del sistema Cerro de la Gloria. Los resultados obtenidos fueron contrastados con datos de subsuelo y resolución de mecanismos focales de sismos locales superficiales.","palabras_clave":"Neotectónica|Sismicidad Superficial|Riesgo sísmico|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38840,"idioma_id":4,"titulo":"Brucella cyclic &#946;-1, 2-glucan plays a critical role in the induction of splenomegaly in mice","resumen":"Brucella, the etiological agent of animal and human brucellosis, is a bacterium with the capacity to modulate the inflammatory response. Cyclic &#946;-1,2-glucan (C&#946;G) is a virulence factor key for the pathogenesis of Brucella as it is involved in the intracellular life cycle of the bacteria. Using comparative studies with different C&#946;G mutants of Brucella, cgs (C&#946;G synthase), cgt (C&#946;G transporter) and cgm (C&#946;G modifier), we have identified different roles for this polysaccharide in Brucella. While anionic C&#946;G is required for bacterial growth in low osmolarity conditions, the sole requirement for a successful Brucella interaction with mammalian host is its transport to periplasmic space. Our results uncover a new role for C&#946;G in promoting splenomegaly in mice. We showed that C&#946;G-dependent spleen inflammation is the consequence of massive cell recruitment (monocytes, dendritics cells and neutrophils) due to the induction of pro-inflammatory cytokines such as IL-12 and TNF-&#945; and also that the reduced splenomegaly response observed with the cgs mutant is not the consequence of changes in expression levels of the characterized Brucella PAMPs LPS, flagellin or OMP16\/19. Complementation of cgs mutant with purified C&#946;G increased significantly spleen inflammation response suggesting a direct role for this polysaccharide.","palabras_clave":"BRUCELLA ABORTUS|SPLENOMEGALY|INFLAMMATION|GLUCANS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38841,"idioma_id":4,"titulo":"Primordial magnetic helicity from stochastic electric currents","resumen":"We study the possibility that primordial magnetic fields generated in the transition between inflation and reheating posses magnetic helicity, HM. The fields are induced by stochastic currents of scalar charged particles created during the mentioned transition. We estimate the rms value of the induced magnetic helicity by computing different four-point scalar quantum electrodynamics Feynman diagrams. For any considered volume, the magnetic flux across its boundaries is in principle not null, which means that the magnetic helicity in those regions is gauge dependent. We use the prescription given by Berger and Field and interpret our result as the difference between two magnetic configurations that coincide in the exterior volume. In this case, the magnetic helicity gives only the number of magnetic links inside the considered volume. We calculate a concrete value of HM for large scales and analyze the distribution of magnetic defects as a function of the scale. Those defects correspond to regular as well as random fields in the considered volume. We find that the fractal dimension of the distribution of topological defects is D=1\/2. We also study if the regular fields induced on large scales are helical, finding that they are and that the associated number of magnetic defects is independent of the scale. In this case, the fractal dimension is D=0. We finally estimate the intensity of fields induced at the horizon scale of reheating and evolve them until the decoupling of matter and radiation under the hypothesis of the inverse cascade of magnetic helicity. The resulting intensity is high enough and the coherence length long enough to have an impact on the subsequent process of structure formation.","palabras_clave":"Cosmology|Magnetic Fields"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38842,"idioma_id":4,"titulo":"Elimination for generic sparse polynomial systems","resumen":"We present a new probabilistic symbolic algorithm that, given a variety defined in an n-dimensional affine space by a generic sparse system with fixed supports, computes the Zariski closure of its projection to a k-dimensional coordinate affine space with k&lt;n. The complexity of the algorithm depends polynomially on combinatorial invariants associated to the supports.","palabras_clave":"PROJECTION OF ALGEBRAIC VARIETIES|SPARSE POLYNOMIALS|ALGORITHMS|COMPLEXITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38843,"idioma_id":4,"titulo":"One-Step Synthesis of Xanthones Catalyzed by a Highly Efficient Copper-Based Magnetically Recoverable Nanocatalyst","resumen":"A versatile and highly efficient strategy to construct a  xanthone skeleton via a ligand-free intermolecular catalytic coupling  of 2-substituted benzaldehydes and a wide range of phenols has been  developed. For this purpose, a novel and magnetically recoverable  catalyst consisting of copper nanoparticles on nanosized silica coated  maghemite is presented. The reaction proceeds smoothly with easy  recovery and reuse of the catalyst. The methodology is compatible  with various functional groups and provides an attractive protocol for  the generation of a small library of xanthones in very good yield.","palabras_clave":"XANTHONES|INTRAMOLECULAR CYCLIZATION|COPPER CATALYSIS|MAGNETIC NANOCATALYST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38844,"idioma_id":4,"titulo":"Is low fruiting success linked to sexual expression in Acacia caven?","resumen":"In long-lived plants, sexual expression can be highly variable in time and space. The extent to which sexual dimorphism of flowers is expressed in the same or in separate individuals, may have implications for the plants´ dependence on pollen vectors, the compatibility of the pollen received, and the potential for setting fruit under distinct pollination environments. Here, we account for variability in sexual expression in the small tree Acacia caven, which produces hermaphrodite and male flowers on the same or in separate individuals. We focus on whether individual sexual expression influences fruit set, which has been reported to be extremely low in this species. Individual sexual expression, estimated as the hermaphrodite:male flowers ratio was variable both  within and among plants across two reproductive seasons. Though male flower production could be very high (up to 99% of the flowers), all trees produced both flower types within the same individual, thus confirming andromonoecy in this species. More interestingly, hermaphrodite:male flowers ratio had a negative effect on fruit set. This pattern was consistent across two reproductive seasons and suggests that maleness should favor female function. Similar trends found in other plant species with the same sexual system support the hypothesis that male flowers of andromonoecious species should contribute to reduce self-pollen interference compared with hermaphrodite flowers. By increasing pollen quality and fruit set, maleness would then help to maintain andromonoecy in this and other andromonoecious species.","palabras_clave":"andromonoecy|fruit set|honey bees|sexual dimorphism"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38845,"idioma_id":4,"titulo":"Prostaglandins in semen compromise the immune response against sexually transmitted pathogens","resumen":"Seminal plasma is not just a spermatozoa carrier. It induces the expression of inflammatory cytokines and chemokines and a massive infiltration of neutrophils, monocytes and dendritic cells (DCs) in the female genital mucosa after coitus, enabling the innate immune system to fight against sexually transmitted pathogens. However, exposure to seminal plasma not only turns on an inflammatory response but also induces regulatory mechanisms that allow the fetus (a semiallograft) to grow and develop in the uterus. In mouse models it has been shown that seminal plasma induces the expansion of regulatory T cells (Tregs) specific to seminal Ags in the receptive partner, thus promoting tolerance to paternal alloantigens and avoiding allogeneic fetal rejection. These mechanisms appear to be mainly induced by prostaglandins of the E series (PGE) and TGF-b, which are present at huge concentrations in the seminal plasma. Moreover, we have recently shown that exposure to seminal plasma induces the differentiation of DCs into a tolerogenic profile through a mechanism dependent on the activation of the prostanoid receptors EP2 and EP4 by seminal PGE. ","palabras_clave":"PROSTAGLANDINAS|SEMEN|INFECCIÓN VIRAL|INMUNIDAD ANTIVIRAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38846,"idioma_id":5,"titulo":"Ideología y lucha de clases en los clásicos del marxismo","resumen":"INDIZADA EN: Latindex (Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal) Catálogo (certifica 34 características, incluido el par 20\/21, sistema de arbitraje y evaluadores externos); CLASE (Citas Latinoamericanas en Ciencias Sociales y Humanidades); RedALyC (Red de Revistas Científicas de América Latina y el Caribe). Considerada 'Revista Destacada' por los investigadores del CONICET (Encuesta de revistas en ciencias sociales, CONICET-Centro Redes, www.centroredes.org.ar\/buscador).RESUMEN: Luego del menosprecio posmoderno por el concepto de ideología, este trabajo se inscribe en una revitalización del interés teórico en la problemática marxista a la que se vincula. Su objetivo es analizar la concepción materialista e histórica de las ideologías que propusieron los clásicos del marxismo en sus diferentes escritos. A pesar de ciertas contradicciones y titubeos, entendibles en el contexto teórico de la época en que Marx y Engels desarrollaron su obra, esta concepción nos proporciona una posición que funciona como divisoria de aguas del campo teórico-político: las ideologías no pueden ser pensadas por fuera o más allá de las luchas de clases históricas y sus efectos.","palabras_clave":"ideología|lucha de clases|teoría marxista|Marx"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38847,"idioma_id":4,"titulo":"High Polyhydroxybutyrate Production in Pseudomonas extremaustralis Is Associated with Differential Expression of Horizontally Acquired and Core Genome Polyhydroxyalkanoate Synthase Genes","resumen":"Pseudomonas extremaustralis produces mainly polyhydroxybutyrate (PHB), a short chain length polyhydroxyalkanoate (sclPHA) infrequently found in Pseudomonas species. Previous studies with this strain demonstrated that PHB genes are located in a genomic island. In this work, the analysis of the genome of P. extremaustralis revealed the presence of another PHB cluster phbFPX, with high similarity to genes belonging to Burkholderiales, and also a cluster, phaC1ZC2D, coding for medium chain length PHA production (mclPHA). All mclPHA genes showed high similarity to genes from Pseudomonas species and interestingly, this cluster also showed a natural insertion of seven ORFs not related to mclPHA metabolism. Besides PHB, P. extremaustralis is able to produce mclPHA although in minor amounts. Complementation analysis demonstrated that both mclPHA synthases, PhaC1 and PhaC2, were functional. RT-qPCR analysis showed different levels of expression for the PHB synthase, phbC, and the mclPHA synthases. The expression level of phbC, was significantly higher than the obtained for phaC1 and phaC2, in late exponential phase cultures. The analysis of the proteins bound to the PHA granules showed the presence of PhbC and PhaC1, whilst PhaC2 could not be detected. In addition, two phasin like proteins (PhbP and PhaI) associated with the production of scl and mcl PHAs, respectively, were detected. The results of this work show the high efficiency of a foreign gene (phbC) in comparison with the mclPHA core genome genes (phaC1 and phaC2) indicating that the ability of P. extremaustralis to produce high amounts of PHB could be explained by the different expression levels of the genes encoding the scl and mcl PHA synthases.","palabras_clave":"PSEUDOMONAS|POLIHIDROXIALCANOATOS|POLIHIDROXIBUTIRATO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38848,"idioma_id":4,"titulo":"Habitat-related differences in the pre-copulatory guarding and copulation behavior of Neohelice granulata (Brachyura, Grapsoidea, Varunidae)","resumen":"Mating behavior strategies of brachyuran crabs are flexible depending on the habitat and social context.We evaluate pre-copulatory guarding in Neohelice granulata and describe the unusual copulatory behavior. Laboratory experiments were conducted to test whether factors such as male size, presence of burrows, a male-biased operational sex ratio (OSR) and female mating history affect the copulation duration in two different study areas.Females initiated a searching behavior approximately 20?26 h before they became receptive by assessing large male burrows and displaying a courtship behavior (?flirting?) in its entrance. Once the female entered inside the male burrow, pre-copulatory guarding was observed until the female became receptive and successful copulation occurred immediately after. This species shows some very unusual copulatory behavior involving eyestalk grasping not seen in any other varunid crab. The copulation duration was independent ofmale size and thepresence of burrows, although it was dependent on the study area, the OSR and the femalemating history. Thus, copulation duration is a flexible character in this species which varies with habitat and biological factors such as mating history and sex ratio.","palabras_clave":"pre-copulatory guarding|copula|inter-population differences|grapsoidea"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38849,"idioma_id":4,"titulo":"Ocean-estuarine connection for ichthyoplankton through the inlet channel of a temperate choked coastal lagoon (Argentina)","resumen":"We examined fish larvae recruitment patterns to Mar Chiquita coastal lagoon  22 (Argentina) during summer 2009-2010. We hypothesized that in this microtidal  23 environment wind patterns could regulate the dynamics of fish larvae recruitment to the  24 lagoon. Ichthyoplankton samples were taken in marine waters, the surf zone and the  25 estuary. Previous studies show no reproduction by fishes with planktonic eggs inside the  26 lagoon, so recent eggs occurring throughout the study area were considered as spawned  27 at sea. Species richness and average larvae density were higher offshore than in the  28 lagoon. Within the lagoon, Brevoortia aurea larvae were dominant. The lowest larvae  29 density and diversity in the surf zone account for an area that is used only as a transient  30 corridor between the sea and the lagoon. Multivariate analysis showed that onshore  31 winds did the highest contribution in explaining data variability for most of the species,  32 while tides cannot explain larvae patterns. Our results show how winds, in addition to  33 pushing seawater into the lagoon, contribute to larvae recruitment into this estuary.  34 Finally, we discuss the role of small lagoons in the life-history of coastal fishes.  Page 2 of 40  www.publish.csiro.au\/journals\/mfr  Marine and Freshwater Research  For Review Only  2  35  36 Additional keywords: Fish larvae, ocean-estuarine gradient, recruitment patterns,  37 choked coastal lagoon, surf zone, wind effect.","palabras_clave":"FISH|RECRUITMENT|DIVERSITY|ESTUARINE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38850,"idioma_id":4,"titulo":"REPRODUCTIVE SYSTEM AND SIZE MATURITY OF THE PADDLE CRAB OVALIPES TRIMACULATUS (BRACHYURA: PORTUNIDAE) ALONG THE ARGENTINE COAST","resumen":"Ovalipes trimaculatus (de Haan, 1833) is a commercial species captured in the Mar del Plata coast, Argentina. However, no studies wereconducted in order to study its population features neither its reproductive biology. The morphometric and physiological maturity of bothsexes, the histology of the female seminal receptacle and ovary, and the ultrastructure of the male gonopods were studied in the presentpaper. In females, morphometric maturity (44.6 mm of carapace width, CW) was acquired prior to physiological maturity (54.6 mm CW).By contrast, in males, physiological maturity (46.6 mm CW) was acquired prior to morphometric maturity (52.3 mm CW). The ovary isconnected to the dorsal part of the seminal receptacle. Neither Spermatophores, nor sperm packets were found inside the seminal receptacle;instead free spermatozoids were observed indicating that sperm from different males is probably mixed favoring sperm competition. Theultrastructure of the male gonopods was similar to the described for other Brachyura. Different types of setae and the presence of internalrosette glands were described and probable functions were suggested.","palabras_clave":"Maturity|Portunidae|Reproduction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38851,"idioma_id":4,"titulo":"The LonB protease controls membrane lipids composition and is essential for viability in the extremophilic haloarchaeon Haloferax volcanii","resumen":"Although homologs of the ATP-dependent Lon protease exist in all domains of life, the relevance of this protease in archaeal physiology remains a mystery. In this study, we have constructed and phenotypically characterized deletion and conditional lon mutants in the model haloarchaeon Haloferax volcanii to elucidate the role of the unusual membrane-bound LonB protease in archaea. Hvlon could be deleted from the chromosome only when a copy of the wild type gene was provided in trans suggesting that Lon is essential for survival in this archaeon. Successful complementation of the lethal phenotype of &#916;Hvlon was attained by expression of the heterologous protease geneNmlon from the haloalkaliphilic archaeon Natrialba magadii, meaning that the biological function of Lon is conserved in these organisms. Suboptimal cellular levels of Lon protein affected growth rate, cell shape, cell pigmentation, lipid composition and sensitivity to various antibiotics. The contents of bacterioruberins and some polar lipids were increased in the lon mutants suggesting that Lon is linked to maintenance of membrane lipid balance which likely affects cell viability in this archaeon. The phenotypes associated to a membrane-bound LonB protease mutant were examined for the first time providing insight on the relevance of this protease in archaeal physiology","palabras_clave":"PROTEASE|ARCHAEA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38852,"idioma_id":4,"titulo":"Process View for a Data Stream Processing Strategy based on Measurement Metadata","resumen":"The data stream processing strategy based on measurement metadata, is an enhanced approach that relies on a measurement and evaluation conceptual framework. The strategy uses measures (data sets) and their linked metadata to incorporate detective and predictive behavior as well as to trigger alarms in a proactive way. This work discusses the process formalization for its data stream processing components, and their interactions. The process specification is based on the SPEM language, and the main specified activities ranges from data source configuration of heterogeneous data sources, to statistical analysis and classifiers for decision making. As result, the proposed strategy becomes more consistent, repeatable and communicable from the process modeling viewpoint. Also, to illustrate the approach, excerpts of a developed outpatient monitoring system are used.","palabras_clave":"Data Stream|Process|Measure|Metadata"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38853,"idioma_id":5,"titulo":"Estrategia de Monitoreo de los Procesos Previsionales del Instituto de Seguridad Social (La Pampa), Soportado por un Marco Conceptual de Medición y Evaluación, para Análisis Preventivo en Toma de Decisiones","resumen":"Este trabajo resume los principales aportes y contribuciones vertidos en la tesis que lleva la misma denominación que el presente artículo, para la obtención del título de Magíster en Ingeniería en Calidad de la Universidad Tecnológica Nacional, Regional Córdoba. Dicha tesis se enmarca dentro del Proyecto de Investigación acreditado mediante Resolución CD 066\/2012 de la Facultad de Ciencias Económicas y Jurídicas (UNLPam). El trabajo abordó la modelización de los procesos del Servicio de Previsión Social perteneciente al Instituto de Seguridad Social de La Pampa, mediante el empleo de un meta modelo de procesos denominado SPEM (en inglés, Software and Systems Process Engineering Meta-model) de la OMG (Object Management Group), una síntesis aquí es presentada. La difusión y aceptabilidad de este meta modelo a nivel internacional, permite hacer los procesos modelados comprensibles, comunicables e interoperables para con terceros. Luego, mediante el empleo de un marco formal de medición y evaluación se sintetiza aquí la estrategia de monitoreo en tiempo real sobre los procesos formalizados mediante SPEM, la cual podría embeberse dentro de los sistemas pre-existentes, y de este modo abastecer tableros de comandos en forma proactiva. Finalmente, se ilustra el prototipo de interfaces asociado con el monitoreo de procesos","palabras_clave":"Procesos Previsionales|Formalización|Medición y Evaluación|Instituto de Seguridad Social de La Pampa"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38854,"idioma_id":4,"titulo":"Influence of the addition of lupine protein isolate on the protein and technological  characteristics of dough and fresh bread with added Brea Gum","resumen":"The effect of protein lupine isolate (LI) and addition of brea gum (BG) on a basic bread formulation is described. The major   objective of this research was to evaluate the influence of the addition of LI on the quality and quantity of the proteins of fresh   bread with BG. Protein quality was determinate by the Chemical Score method corrected for protein digestibility (CSCD%).   The bread dough characteristics were determined by farinograph and alveograph. Fresh bread characterization was performed   by measuring the physical parameters and evaluating the crumb structure. The effect of LI and BG on available lysine, the loss   of available lysine ratio, and the chemical composition of the breads were also determined. The addition of LI on the bread   formulation improved the protein content and the CSCD% of lysine. The dough with LI was less resistant to prolonged kneading   and less manageable. With BG addition, the dough became stickier. The quality of fresh bread was affected by the addition of LI:   the fresh bread had lower specific volume and more heterogeneous crumbs than that of the control group. The addition of BG   did not influence the quality of the bread made with the mixed flour, but it had a positive effect on the loss of available lysine.","palabras_clave":"protein lupine isolate|brea gum|dough characteristics|bread quality"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38855,"idioma_id":4,"titulo":"Association of cellular and molecular alterations in Leydig cells with apoptotic changes in germ cells from testes of Graomys griseoflavus x Graomys centralis male hybrids","resumen":"Spermatogenesis is disrupted in Graomys griseoflavus × Graomys centralis male hybrids. This study was aimed to determine whether morphological alterations in Leydig cells from hybrids accompany the arrest of spermatogenesis and cell death of germ cells and whether apoptotic pathways are also involved in the response of these interstitial cells. We used three groups of 1-, 2- and 3-month-old male animals: (1) G. centralis, (2) G. griseoflavus and (3) hybrids obtained by crossing G. griseoflavus females with G. centralis males. Testicular ultrastructure was analyzed by transmission electron microscopy. TUNEL was studied using an in situ cell death detection kit and the expression of apoptotic molecules by immunohistochemistry. The data confirmed arrest of spermatogenesis and intense apoptotic processes of germ cells in hybrids. These animals also showed ultrastructural alterations in the Leydig cells. Fas, FasL and calbindin D28k overexpression without an increase in DNA fragmentation was detected in the Leydig cells from hybrids. In conclusion, the sterility of Graomys hybrids occurs with ultrastructural changes in germ and Leydig cells. The enhancement of Fas and FasL is not associated with cell death in the Leydig cells. Probably the apoptosis in these interstitial cells is inhibited by the high expression of the antiapoptotic molecule calbindin D28k.","palabras_clave":"GRAOMYS GRISEOFLAVUS|GRAOMYS CENTRALIS|HYBRIDS|LEYDIG CELLS|GERM CELLS|TESTES|ULTRASTRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38856,"idioma_id":4,"titulo":"Survival and growth of Nothofagus pumilio seedlings under several microenvironments after variable retention harvesting in southern Patagonian forests","resumen":"Variable retention prescriptions for Nothofagus pumilio forests provide for biodiversity conservation and natural regeneration by controlled opening of the canopy. Harvesting generates different microenvironments which present dissimilar conditions for seedling establishment, due to positive or negative influences over biotic and abiotic factors.This study evaluated seedling survival and performance in different microenvironments within the harvested stands. Tested hypotheses stated that seedling stress and performance were influenced by harvesting due to changes in. forest structure, microclimate, soil properties, and nutrient availability.In the stands harvested by variable retention, five contrasting microenvironments were selected as treatments for the experiments and sampling. Environmental variables were related to ecophysiological, seedling survival, and performance. The modification of forest structure (crown cover and tree density) and the presence of coarse woody debris greatly affect the effective rainfall and global radiation reaching understorey level, influencing seedling stress and consequently survival and performance. Harvesting also modifies soil properties (e.g., soil bulk density) and coarse woody debris accumulation which in turn influences soil moisture and\/or solar radiation levels. Analyses showed that seedlings received benefits of microenvironment variation after harvesting. Areas covered with middle or fine woody debris presented regeneration with better ecophysiological response and seedling performance, although dispersed retention areas (far away from remnant trees) and roads could also present suitable conditions for seedling survival and performance. The proportion of different microenvironments in the harvested forests will determine the amount of natural recruitment of regeneration and consequently the success of proposed silvicultural management. Forest practices must be manipulated to increase the proportion of favorable microenvironments (e.g., woody debris), allowing greater natural regeneration success during the first years after harvesting. ","palabras_clave":"AGGREGATED RETENTION|DISPERSED RETENTION|MICROENVIRONMENTS  |LIGHT AVAILABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38858,"idioma_id":5,"titulo":"Influencia de la incorporación de nanopartículas de talco sobre las propiedades finales de almidón termoplástico","resumen":"Las propiedades mecánicas y de barrera son aspectos críticos para desarrollar películas para envasado de alimentos. Así, se propone mejorar ambos aspectos en películas de almidón termoplástico (TPS) incorporando nanopartículas de talco. Se obtuvieron películas por termocompresión con 0, 1, 3 y 5 % p\/p de partículas minerales. La incorporación de talco aumentó la estabilidad térmica del TPS y modificó la opacidad y el color, sin alterar la absorción UV. Las permeabilidades al vapor de agua y al oxígeno disminuyeron significativamente. Los bionanocompuestos presentaron mayor resiliencia, tenacidad y módulo elástico que las películas de TPS, sin afectar la elongación a la ruptura.","palabras_clave":"ALMIDÓN TERMOPLÁSTICO|NANOPARTÍCULAS DE TALCO|TERMOCOMPRESIÓN|PERMEABILIDAD AL OXÍGENO Y VAPOR DE AGUA|PROPIEDADES MECÁNICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38859,"idioma_id":4,"titulo":"Raf-MEK-ERK pathway activation is required for Junin virus replication","resumen":"In the present work we investigated the importance of the Raf\/MEK\/ERK signalling pathway in the multiplication of the arenavirus Junín (JUNV) in monkey and human cell cultures. We established that JUNV induces a biphasic activation of ERK and we proved that a specific inhibitor of the ERK pathway, U0126, impairs viral replication. Furthermore, U0126 exerted inhibitory action against the arenaviruses Tacaribe and Pichinde. Moreover, treatment with known ERK activators such as phorbol 12-myristate 13-acetate and serum increased viral yields whereas ERK silencing by small interfering RNAs caused the inhibition of viral multiplication. Therefore, activation of the Raf\/MEK\/ERK signalling pathway is required to ensure efficient JUNV replication and may constitute a host target for the development of novel effective therapeutic strategies to deal with arenavirus infections.","palabras_clave":"ERK|JUNIN VIRUS|ARENAVIRUS|REPLICATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38860,"idioma_id":4,"titulo":"Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6\/36 cells","resumen":"The aim of the present study was to analyze the influence of virus origin, mammalian or mosquito cell-derived, on antiviral susceptibility of DENV-2 to entry inhibitors and the association of this effect with any alteration in the mode of entry into the cell. To this end, ten serial passages of DENV-2 were performed in mosquito C6\/36 cells or monkey Vero cells and the antiviral susceptibility of each virus passage to sulfated polysaccharides (SP), like heparin and carrageenans, was evaluated by a virus plaque reduction assay. After serial passaging in Vero cells, DENV-2 became increasingly resistant to SP inhibition whereas the antiviral susceptibility was not altered in virus propagated in C6\/36 cells. The change in antiviral susceptibility was associated to a differential mode of entry into the host cell. The route of endocytic entry for productive Vero cell infection was altered from a non-classical clathrin independent pathway for C6\/36-grown virus to a clathrin-mediated endocytosis when the virus was serially propagated in Vero cells. Our results show the impact of the cellular system used for successive propagation of DENV on the initial interaction between the host cell and the virion in the next round of infection and the relevant consequences it might have during the in vitro evaluation of entry inhibitors.","palabras_clave":"DENGUE VIRUS|ANTIVIRAL |ENTRY|POLYSACHARIDES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38861,"idioma_id":4,"titulo":"Co-expression and characterization of enterocin CRL35 and its mutant in Escherichia coli Rosetta","resumen":"Even though many sequences and structures of bacteriocins from lactic acid bacteria have been fully characterized so far, little information is currently available about bacteriocins heterologously produced by Escherichia coli. For this purpose, the structural gene of enterocin CRL35, munA, was PCR-amplified using specific primers and cloned downstream PelB sequence in the pET22b (+) expression vector. E. coli Rosetta (DE3) pLysS was chosen as the host for production and enterocin was purified by an easy two-step protocol. The bacteriocin was correctly expressed with the expected intramolecular disulfide bond. Nevertheless, it was found that a variant of the enterocin, differing by 12 Da from the native polypeptide, was co-expressed by E. coli Rosetta in comparable amount. Indeed, the mutant bacteriocin contained two amino acid substitutions that were characterized by matrix assisted laser desorption ionization-time of flight (MALDI-TOF) and HPLC-electrospray (ESI)-Q-TOF tandem mass spectrometry (MS\/MS) sequencing. This is the first report regarding the production of mutants of pediocin-like bacteriocins in the E. coli expression system.","palabras_clave":"BACTERIOCINS|HETEROLOGOUS EXPRESSION|MALDI TOF MS ANALYSIS|NANO HPLC-ESI MS\/MS ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38862,"idioma_id":5,"titulo":"Devociones marianas en la ciudad de San Carlos de Bariloche (Argentina): construcciones identitarias sociales y marcas territoriales","resumen":"Las distintas advocaciones marianas locales construyen espacios sagrados. Allí, la dinámica de la memoria colectiva, interpela desde sus narrativas devocionarias a la fragmentación social y al carácter aluvional de Bariloche. Estas advocaciones se transforman en símbolos sociales locales. Desde allí, transmiten la visibilización de los conflictos sociales de los distintos sectores urbanos a través de los rituales y peregrinaciones, dibujando un territorio que se entrecruza y se fragmenta en cada construcción devocional. La práctica cultual de estas advocaciones marianas generaron y generan identidades. También construyen territorios que hacen visible la fragmentación social barilochense. Para ello, hemos identificado dos grupos de advocaciones: las que han sido traídas por la migración latinoamericana asentada y aquellas a las que denominamos propiamente barilochenses. En el primer caso, analizamos a las Vírgenes migrantes: la de Caacupé de los paraguayos y la del Carmen de la migración chilena. En el segundo caso, tomamos como advocaciones locales a la Virgen de las Nieves, Patrona de la Diócesis de Bariloche y a la Virgen de Nahuel Huapi, Patrona de la ciudad.","palabras_clave":"VIRGENES LOCALES|VIRGENES MIGRANTES|SAN CARLOS DE BARILOCHE|DEVOCIONES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38863,"idioma_id":4,"titulo":"A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues","resumen":"Introduction: Embryonic stem cells and induced pluripotent stem cells have  emerged as the gold standard of pluripotent stem cells and the class of  stem cell with the highest potential for contribution to regenerative and  therapeutic application; however, their translational use is often impeded  by teratoma formation, commonly associated with pluripotency. We discuss  a population of nontumorigenic pluripotent stem cells, termed Multilineage  Differentiating Stress Enduring (Muse) cells, which offer an innovative and  exciting avenue of exploration for the potential treatment of various  human diseases.  Areas covered: This review discusses the origin of Muse cells, describes in  detail their various unique characteristics, and considers future avenues of  their application and investigation with respect to what is currently known  of adult pluripotent stem cells in scientific literature. We begin by defining  cell potency, then discuss both mesenchymal and various reported populations  of pluripotent stem cells, and finally delve into Muse cells and the  characteristics that set them apart from their contemporaries.  Expert opinion: Muse cells derived from adipose tissue (Muse-AT) are  efficiently, routinely and painlessly isolated from human lipoaspirate  material, exhibit tripoblastic differentiation both spontaneously and under  media-specific induction, and do not form teratomas. We describe qualities  specific to Muse-ATcells and their potential impact on the field of regenerative  medicine and cell therapy.","palabras_clave":"HUMAN PLURIPOTENT STEM CELLS|MUSE CELLS|NONTUMORIGENIC|REGENERATIVE MEDICINE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38864,"idioma_id":4,"titulo":"Understanding the function of bacterial and eukaryotic thiolases II by integrating evolutionary and functional approaches","resumen":"Acetoacetyl-CoA thiolase (EC 2.3.1.9), commonly named thiolase II, condenses two molecules of acetyl-CoA to give acetoacetyl-CoA and CoA. This enzyme acts in anabolic processes as the first step in the biosynthesis of isoprenoids and polyhydroxybutyrate in eukaryotes and bacteria, respectively. We have recently reported the evolutionary and functional equivalence of these enzymes, suggesting that thiolase II could be the rate limiting enzyme in these pathways and presented evidence indicating that this enzyme modulates the availability of reducing equivalents during abiotic stress adaptation in bacteria and plants. However, these results are not sufficient to clarify why thiolase II was evolutionary selected as a critical enzyme in the production of antioxidant compounds. Regarding this intriguing topic, we propose that thiolase II could sense changes in the acetyl-CoA\/CoA ratio induced by the inhibition of the tricarboxylic acid cycle under abiotic stress. Thus, the high level of evolutionary and functional constraint of thiolase II may be due to the connection of this enzyme with an ancient and conserved metabolic route.","palabras_clave":"THIOLASE II|CoA|ACETYL-CoA|TRICARBOXYL ACID CYCLE|ANTIOXIDANT COMPOUNDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38865,"idioma_id":4,"titulo":"Superconducting heterostructures: from antipinning to pinning potentials","resumen":"We study vortex lattice dynamics in a heterostructure that combines two type-II superconductors: a niobium film and a dense triangular array of submicrometric vanadium (V) pillars. Magnetic ac susceptibility measurements reveal a sudden increase in ac penetration, related to an increase in vortex mobility above a magnetic field, ${{H}^{*}}\\left( T \\right)$, that decreases linearly with temperature. Additionally, temperature independent matching effects that occur when the number of vortices in the sample is an integer of the number of V pillars, strongly reduce vortex mobility, and were observed for the first and second matching fields, ${{H}_{1}}$ and ${{H}_{2}}$. The angular dependence of ${{H}_{1}}$, ${{H}_{2}}$ and ${{H}^{*}}\\left( T \\right)$ shows that matching is determined by the normal applied field component, while ${{H}^{*}}\\left( T \\right)$ is independent of the applied field orientation. This important result identifies ${{H}^{*}}\\left( T \\right)$ with the critical field boundary for the normal to superconducting transition of V pillars. Below ${{H}^{*}}\\left( T \\right)$, superconducting V pillars repel vortices, and the array becomes an 'antipinning' landscape that is more effective in reducing vortex mobility than the 'pinning' landscape of the normal V sites above ${{H}^{*}}\\left( T \\right)$. Matching effects are observed both below and above ${{H}^{*}}\\left( T \\right)$, implying the presence of ordered vortex configurations for 'antipinning' or 'pinning' arrays.","palabras_clave":"SUPERCONDUCTIVITY|VORTEX|FILMS|NANOTECHNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38866,"idioma_id":5,"titulo":"Racionalidad humana en el dilema del viajero y juegos similares","resumen":"En su artículo de 1994, Kaushik Basu presenta el juego denominado ?dilema de viajero? (DV)como desafío para la Teoría de Juegos. Efectivamente, la solución prescripta por dicha teoríava en contra de la intuición ?acordada por expertos- sobre qué es racional hacer en dicho juego.Los resultados de estudios experimentales muestran que la mayoría de participantes respondende manera consistente con tal intuición. Esto podría considerarse como una validación ?almenos en el contexto del DV- del supuesto de racionalidad omnipresente en muchos modelosde conducta humana, especialmente en economía. Nosotros nos preguntamos si las personasrealmente deciden de manera racional en el DV y juegos similares. Para ello, realizamosuna serie de estudios experimentales que reseñamos en este trabajo. Argumentamos que, paracierta variación del DV, se registra una tendencia a comportarse irracionalmente, pero esatendencia se revierte cuando se aclaran las relaciones entre medios y fines.","palabras_clave":"Racionalidad|Teoría de Juegos|Dilema del Viajero|Experimentos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38867,"idioma_id":4,"titulo":"First report of phenoloxidase and peroxidase activities in two intertidal sea anemone  species of Argentina","resumen":"The presence of immune responses within sea anemone species has received little attention, in comparison with coral species, so we decided to investigate the phenoloxidase and peroxidase activities in ectoderm, endoderm and tentacles of actiniarians Aulactinia marplatensis and Bunodosoma zamponii, the most common species in intertidal zone of Mar del Plata, Argentina. Enzyme activities were detected in all tissues evaluated with some differences among tissues and species. Phenoloxidase and peroxidase activities are associated with the mechanisms of innate immunity in invertebrates, and the high production of phenoloxidase observed in B. zamponii would provide a continual level of resistance to infection and this species to be less susceptible to stress and disease, compared to A. marplatensis. This study, represents the first step toward specific immune information about the mentioned sea anemone species of Argentina, and thus permits prediction of the potential effects of environmental factors on immune response.","palabras_clave":"IMMUNITY|PEROXIDASE|PHENOLOXIDASE|SEA ANEMONE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38868,"idioma_id":4,"titulo":"Experimental and theoretical study of the efficiency of a three-electrode reactor for the removal of NO","resumen":"An experimental and theoretical study is presented of the efficiency of removal of NO in a N2 atmosphere in a novel three-electrode reactor. This reactor combines a dielectric-barrier discharge with a corona discharge, designed to enhance streamer propagation in a relatively large region. Experimentally, the reactor has a good energy yield for the removal of NO, as compared with other discharge methods. A theoretical model is developed for the production of reactive species in the streamers by different reactions that allow to relate simple electrical measurements with the reactor efficiency. This theoretical efficiency resulted in good agreement with the experimental one, validating the model and allowing the evaluation of the contribution of different reactions involved in NO removal.","palabras_clave":"nonthermal plasma,|NO removal|electric discharge"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38869,"idioma_id":4,"titulo":"Corrections to the Berry phase in a solid-state qubit due to low frequency noise","resumen":"We present a quantum open-system approach to analyze the nonunitary dynamics of a superconducting qubit when it evolves under the influence of external noise. We consider the presence of longitudinal and transverse environmental fluctuations affecting the system's dynamics and model these fluctuations by defining their correlation function in time. By using a Gaussian-like noise correlation, we can study low- and high-frequency noise contribution to decoherence and implement our results in the computation of geometric phases in open quantum systems. We numerically study when the accumulated phase of a solid-state qubit can still be found close to the unitary (Berry) one. Our results can be used to explain experimental measurements of the Berry phase under high-frequency fluctuations and design experimental future setups when manipulating superconducting qubits.","palabras_clave":"Fases Geométricas|Decoherencia|Qubit superconductor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38870,"idioma_id":4,"titulo":"Equine Arteritis Virus gP5 Protein Induces Apoptosis in Cultured Insect Cells","resumen":"Equine Arteritis Virus (EAV) has been shown to induce apoptosis in vitro but the induction of this mechanism has not been previously associated with any viral gene product. In this work, we found a citotoxicity effect of the EAV gP5 protein on baculovirus-insect cells and a low yield of protein recovery. Besides, different morphological features by electron transmission microscopy, DNA fragmentation in agarose gel, TUNEL analysis and caspase 3 activity were found. All these findings indicate that the EAV gP5 protein induces apoptosis in insect cells.","palabras_clave":"apoptosis|Equine arteritis virus|Insect cells"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38871,"idioma_id":4,"titulo":"Development of a peptide ELISA for the diagnosis of Equine arteritis virus","resumen":"ABSTRACT  A peptide-based indirect ELISA was developed to detect antibodies against Equine arteritis virus (EAV). Two peptides for epitope C of protein GP5 and fragment E of protein M were designed, synthesized, purified and used as antigens either alone or combined. Ninety-two serum samples obtained from the 2010 equine viral arteritis outbreak, analyzed previously by virus neutralization, were evaluated by the ELISA here developed. The best resolution was obtained using peptide GP5. The analysis of the inter- and intraplate variability showed that the assay was robust. The results allow concluding that this peptide-based ELISA is a good alternative to the OIE-prescribed virus neutralization test because it can be standardized between laboratories, can serve as rapid screening, can improve the speed of diagnosis of EAV-negative horses and can be particularly useful for routine surveillance in large populations.","palabras_clave":"ELISA|peptidos|Equine arteritis virus"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38872,"idioma_id":5,"titulo":"Relevamiento serológico de anticuerpos contra enfermedades","resumen":"Las poblaciones de llamas de  Argentina se concentran principalmente en la provincia de Jujuy; su explotación  representa un importante recurso económico de las comunidades altoandinas. El  objetivo de este trabajo fue evaluar la seroprevalencia de anticuerpos contra  algunos agentes virales asociados a enfermedades de impacto productivo en  rodeos de llamas de Jujuy. Se analizaron 349 sueros de llamas adultas de 6  departamentos de la puna jujeña ubicados por encima de los 3300 msnm. Se obtuvo  una prevalencia del 100 % para rotavirus grupo A y del 70 % para el virus  parainfluenza-3 bovino, mientras que no se detectaron reactores para  herpesvirus bovino 1, virus de la diarrea viral bovina, influenza A humana  (H1N1) e influenza equina (H3N8). Los resultados obtenidos confirman la amplia  distribución de rotavirus y virus parainfluenza y la baja susceptibilidad a herpesvirus  y pestivirus en las tropas de llamas de la puna jujeña. ","palabras_clave":"LLAMAS|ROTAVIRUS|PESTIVIRUS|HERPESVIRUS|INFLUENZA|PARAINFLUENZA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38873,"idioma_id":4,"titulo":"Partial preservation of chiral symmetry and colossal magnetoresistance in adatom doped graphene","resumen":"We analyze the electronic properties of adatom-doped graphene in the low-impurity-concentration regime. We focus on the Anderson localized regime and calculate the localization length &#958; as a function of the electron doping and an external magnetic field. The impurity states hybridize with carbon´s pz states and form a partially filled band close to the Dirac point. Near the impurity band center, the chiral symmetry of the system´s effective Hamiltonian is partially preserved, which leads to a large enhancement of &#958;. The sensitivity of transport properties, namely, Mott´s variable range hopping scale T0, to an external magnetic field perpendicular to the graphene sheet leads to a colossal magnetoresistance effect, as observed in recent experiments.","palabras_clave":"Quantum Transport|Graphene|Localization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38874,"idioma_id":4,"titulo":"Transport through side-coupled multilevel double quantum dots in the Kondo regime","resumen":"We analyze the transport properties of a double quantum dot device in the side-coupled configuration. A small quantum dot (QD), having a single relevant electronic level, is coupled to source and drain electrodes. A larger QD, whose multilevel nature is considered, is tunnel-coupled to the small QD. A Fermi-liquid analysis shows that the low-temperature conductance of the device is determined by the total electronic occupation of the double QD. When the small dot is in the Kondo regime, an even number of electrons in the large dot leads to a conductance that reaches the unitary limit, while for an odd number of electrons a two-stage Kondo effect is observed and the conductance is strongly suppressed. The Kondo temperature of the second-stage Kondo effect is strongly affected by the multilevel structure of the large QD. For increasing level spacing, a crossover from a large Kondo temperature regime to a small Kondo temperature regime is obtained when the level spacing becomes of the order of the large Kondo temperature.","palabras_clave":"QUANTUM|DOT|TRANSPORT|CORRELATIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38875,"idioma_id":4,"titulo":"Electrochemical Generation of Porphyrin-Porphyrin and Porphyrin-C60 Polymeric Photoactive Organic Heterojunctions","resumen":"Se adjunta resumen","palabras_clave":"Polymer Heterojunctions|Porphyrins"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38876,"idioma_id":4,"titulo":"Recombination Study of Combined Halides (Cl, Br, I) Perovskite Solar Cells","resumen":"We report on the preparation of a series of9 solution-processed perovskite solar cells based on methyl-10 ammonium (MA) lead halide derivatives, MAPbX3, which11 show tunable optical properties depending on the nature and12 ratio of the halides employed (X = Cl, Br, and I). Devices have13 been prepared with different cell architecture, thin film, and14 mesoporous scaffold (TiO2 and Al2O3). We have analyzed15 different sample sets focusing on the characterization of the16 charge recombination by means of impedance spectroscopy17 (IS). On the one hand, our study discloses that the insertion of18 both Cl and Br in the perovskite lattice reduces the charge19 recombination rates in the light absorber film, thus20 determining the open circuit voltage (Voc) of the device. The samples prepared on a mesoporous Al2O3 electrode present21 lower charge recombination rates than those devices prepared on mesoporous TiO2. Furthermore, the addition of Br in the22 perovskite structure was demonstrated to improve slightly the lifetime of the devices; in fact, the efficiencies of all devices tested23 remained at least at the 80% of the initial value 1 month after their preparation. These results highlight the crucial role of the24 charge-recombination processes on the performance of the perovskite solar cells and pave the way for further progress on this25 field.","palabras_clave":"Perovskite|Solar Cell"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38877,"idioma_id":4,"titulo":"Immune response elicited by the oral administration of an intermediate strain of IBDV in chickens","resumen":"The immune response elicited by the oral inoculation of an intermediate strain of infectious bursal disease virus was studied in chickens. A strong over expression of IL-6, IL-8, IFN&#945; and IFN&#947; was observed in bursa at 3 days post inoculation together with an increase in splenic NO2 release. An influx of T-lymphocytes was also detected.","palabras_clave":"INNATE IMMUNITY|VIRUS DE LA BURSITIS INFECCIOSA|CITOQUINAS AVIARES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38878,"idioma_id":4,"titulo":"Meiotic behavior of two polyploid species of genus Pleurodema (Anura: Leiuperidae) from central Argentina","resumen":"Polyploidy is an important evolutionary force but rare  in vertebrates. However, in anurans, the  genus Pleurodemahas polyploid species, two of them tetraploid and one octoploid. The manner inwhich the chromosomesjoin in diakinesis can vary among species and,  crucially, if they differ in  their ploidy levels. In this work, we describe  the meiotic configurations in two cryptic species from central Argentina, with  different ploidy levels, Pleurodema kriegi  (tetraploid) and P. cordobae  (octoploid). A total of 306 diakineses from 19 individuals were analyzed. In  meiosis, P. kriegi form 22 bivalents,  whereas P. cordobae exhibits variation in meiotic figures. We  discuss the possible allo-  and autopolyploid origin of these species, and we  consider that the autopolyploid origin of P.  cordobae from P. kriegi might be the most feasible.","palabras_clave":"Pleurodema cordobae|Polyploidy|Citogenetics|Diakinesis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38879,"idioma_id":4,"titulo":"Interplay between autophagy and apoptosis in pancreatic tumors in response to gemcitabine","resumen":"Pancreatic cancer is an aggressive disease. Its incidence has  increased over the last two decades. It is currently the fourth cause  of death among cancers in the western world. Unfortunately,  systemic chemotherapy sti l l  rel ies on just a few drugs which unti l  now have produced unsatisfactory resul ts. Gemci tabine (2&#8242;-2&#8242;  -di fluorodeoxycytidine) is currently the standard chemotherapy  treatment at al l  stages of pancreatic adenocarcinoma. Survival  benefi t and cl inical  impact however remain moderate due to a high  degree of intrinsic and acquired resistance. Autophagy plays an  important role in cel l  death decision but can also protect cel ls from  various apoptotic stimul i . We investigated the function of  autophagy in pancreatic carcinoma cel ls, which are frequently  insensi tive to standard chemotherapeutic agents. Here, we  demonstrate that autophagy is one of the mechanisms responsible  for the refractory response of pancreatic tumors to gemci tabine. We  present evidence in vi tro and in vivo that proves autophagy plays a  protective role in pancreatic ductal  carcinoma cel ls, preventing  them from entering the apoptotic pathway after stimulus wi th  gemci tabine, thus contributing to treatment resistance. A better  understanding of the role in the process may help in the discovery  of new strategies to overcome tumor drug resistance in this  aggressive disease","palabras_clave":"Pancreatic tumor|Autophagy|Apóptosis|Drug Resistance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38880,"idioma_id":4,"titulo":"THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge","resumen":"Celiac  disease (CD) is an immune mediated, polygenic disorder, where HLA-DQ2\/DQ8  alleles contribute around 35% to genetic risk, but several other genes are also  involved. Genome-wide association studies (GWASs) and the more recent  immunochip genotyping projects have fine-mapped 39 regions of genetic  susceptibility to the disease, most of which harbor candidate genes that could  participate in this disease process. We focused our attention to the GWAS peak  on chr6: 127.99?128.38 Mb, a region including two genes, thymocyte-expressed  molecule involved in selection (THEMIS) and protein tyrosine phosphatase, receptor  type, kappa (PTPRK), both of which have immune-related functions. The aim of  this work was to evaluate the expression levels of these two genes in duodenal  mucosa of active and treated CD patients and in controls, and to determine whether  SNPs (rs802734, rs55743914, rs72975916, rs10484718 and rs9491896) associated  with CD have any influence on gene expression. THEMIS showed higher expression  in active CD compared with treated patients and controls, whereas PTPRK showed  lower expression. Our study confirmed the association of this region with CD in  our population, but only the genotype of rs802734 showed some influence in the  expression of THEMIS. On the other hand, we found a significant positive correlation  between THEMIS and PTPRK mRNA levels in CD patients but not in controls. Our  results suggest a possible role for both candidate genes in CD pathogenesis and  the existence of complex, regulatory relationships that reside in the vast non-coding,  functional intergenic regions of the genome. Further investigation is needed to  clarify the impact of the disease-associated SNPs on gene function.","palabras_clave":"CELIAC DISEASE|GENETIC ASSOCIATION|THEMIS|PTPRK"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38881,"idioma_id":4,"titulo":"Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen","resumen":"Systemic administration of polyinosinic:polycytidylic acid (poly I:C), mimics virally-induced activation of TLR3 signalling causing acute small intestine damage, but whether and how mucosal administration of poly I:C causes enteropathy is less clear. Our aim was to investigate the inflammatory pathways elicited after intraluminal administration of poly I:C and determine acute and delayed consequences of this locally induced immune activation. Intraluminal poly I:C induced rapid mucosal immune activation in C57BL\/6 mice involving IFNb and the CXCL10\/CXCR3 axis, that may drive inflammation towards a Th1 profile. Intraluminal poly I:C also caused enteropathy and gut dysfunction in gliadin-sensitive NOD-DQ8 mice, and this was prolonged by concomitant oral administration of gliadin. Our results indicate that small intestine pathology can be induced in mice by intraluminal administration of poly I:C and that this is exacerbated by subsequent oral delivery of a relevant dietary antigen.","palabras_clave":"CELIAC DISEASE|MURINE MODEL|POLY I:C"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38882,"idioma_id":4,"titulo":"Survey of Aspergillus section Flavi presence in agricultural soils and effect of glyphosate on non-toxigenic A. flavus growth on soil based medium","resumen":"Aims: To evaluate the cultivable mycobiota from agricultural soils exposed to pesticides, the aflatoxigenic capacity of Aspergillus section Flavi strains and the effect of glyphosate on lag phase and growth rates of native nontoxigenic Aspergillus flavus under different water potential (MPa) conditions on soil based medium.  Methods and Results: Culturable mycobiota analysis from different  agricultural soils was performed by the surface spread method. The effect of glyphosate (0.20 mmol\/l) on the growth of A. flavus strains was evaluated on a soil extract solid medium. Mycobiota analysis of crop soils showed the presence of twenty-one genera of filamentous fungi. Aspergillus flavus and Aspergillus niger aggregate strains were isolated from the three soil types. Ninety-two per cent of A. flavus strains were toxigenic. In vitro assay results showed that at 0.70 MPa, a significant increase in growth rate in all strains was recorded at 5 and 20 mmol l  1 of glyphosate. At 2.78 MPa, this parameter remained constant at all glyphosate concentrations, except in GM4 strain where an increase in growth rate was recorded with increasing pesticide concentrations. At 7.06 MPa, a significant increase in growth rate has also been observed in GM 3 strain with 5 mmol\/l\/and in GM 4 strain with 10 and 20 mmol\/l.  Conclusions: This study showed that the imperfecti fungi Aspergillus spp.,Penicillium spp., Trichoderma spp., Cladosporium spp. and Paecilomyces spp. are isolated as prevalent groups in agricultural soil exposed to pesticides, and the capacity of nontoxigenic A. flavus strains to tolerate different glyphosate concentrations under different water potential (MPa) conditions.  Significance and Impact of the Study: This manuscript makes a contribution to the knowledge of cultivable fungal populations from agricultural soils exposed to pesticides and the glyphosate tolerance of A. flavus strains.","palabras_clave":"GLYPHOSATE|ASPERGILLUS FLAVUS|AGRICULTURAL SOILS|MYCOBIOTA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38883,"idioma_id":4,"titulo":"Reproduction performance, body condition and mastitis of seasonally-calved Holstein cows in a pasture based system","resumen":"The objective of this study was to assess association between clinical, subclinical mastitis, body condition score and the reproductive performance of cows under seasonally calving conditions in a pasture-based management system. Data from 182 cows calved during 2008 were analyzed. Chi-square and logistic regression were performed considering pregnancy at the end of breeding season and number of services as dependent variables, whereas clinical and subclinical mastitis and other variables related to the animal that could have an effect on the dependent variables (e.g. parity, BCS, concurrent diseases) as independent variables. Lactation number, calving difficulty, interval from calving to the beginning of breeding season and body condition score had a significant effect on pregnancy at the end of breeding season. Cows with one or two lactations (P=0.031), those with no difficulty at calving (P=0.003), those with more days from calving to the beginning of breeding season (P=0.001), and those with body condition score >2.5 (P=0.007) were more likely to become pregnant. Subclinical mastitis affected reproductive performance increasing the number of services (P=0.03). Also, breeding season influenced number of services, since summer-calving cows needed more services to become pregnant (P=0.046). Clinical mastitis was not associated with pregnancy as a final measure of reproductive performance (P=0.863). Although subclinical mastitis influenced reproductive performance, several parameters related to reproductive and nutritional management, significantly affected the outcome variables under experimental conditions of this study. This information can be valuable to improve reproductive performance in similar management systems.","palabras_clave":"CLINICAL MASTITIS|SUBCLINICAL MASTITIS|REPRODUCTIVE PERFORMANCE|SEASONAL CALVING HERD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38884,"idioma_id":4,"titulo":"Development of an electrochemical sensor for the determination of the flavonoid luteolin in peanut hull samples","resumen":"We describe the development of an electrochemical sensor based on glassy carbon electrodes modified with  multiwalled carbon nanotubes dispersed in low molecular weight polyethylenimine for the determination of  luteolin in peanut hulls. A well defined quasi-reversible surface redox couple was found using cyclic and square  wave voltammetries for luteolin in 1.0 M HClO4 aqueous solutions. The best accumulation potential and the  accumulation time were 0.55 V and 20 min, respectively. An optimal ratio of 1:5 for multiwalled carbon nanotubes\/  polyethylenimine was used to prepare dispersions.  The linear rangewas from 2.4 × 10&#8722;3 to 1.75 &#956;mol\/L. The luteolin contents determined in two peanut hull sampleswere  (1.18± 0.08) and (1.47± 0.09) g per 100 g of sample, being in very good agreementwith those values  obtained from the same samples using HPLC. The limits of detection and quantification were 5.0 × 10&#8722;10 and  1.5 × 10&#8722;9 M, respectively. The reproducibility and the repeatability were 8.0 and 7.3 %, respectively.  The modified glassy carbon electrode was stable even after 23 days.","palabras_clave":"FLAVONOIDS|LUTEOLIN|MULTIWALLED CARBON NANOTUBES|POLYETHYLENIMINE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38885,"idioma_id":4,"titulo":"Description of a novel adhesin of Mycobacterium avium subsp. paratuberculosis","resumen":"The binding and ingestion of Mycobacterium avium subsp. paratuberculosis   (MAP) by host cells are fibronectin (FN) dependent. In several species   of mycobacteria, a specific family of proteins allows the attachment and   internalization of these bacteria by epithelial cells through   interaction with FN. Thus, the identification of adhesion molecules is   essential to understand the pathogenesis of MAP. The aim of this study   was to identify and characterize FN binding cell wall proteins of MAP.   We searched for conserved adhesins within a large panel of surface   immunogenic proteins of MAP and investigated a possible interaction with   FN. For this purpose, a cell wall protein fraction was obtained and   resolved by 2D electrophoresis. The immunoreactive spots were identified   by MALDI-TOF MS and a homology search was performed. We selected   elongation factor Tu (EF-Tu) as candidate for further studies. We   demonstrated the FN-binding capability of EF-Tu using a ligand blot   assay and also confirmed the interaction with FN in a dose-dependent   manner by ELISA. The dissociation constant of EF-Tu was determined by   surface plasmon resonance and displayed values within the &#956;M range.   These data support the hypothesis that this protein could be involved in   the interaction of MAP with epithelial cells through FN binding","palabras_clave":"MYCOBACTERIUM|ADHESIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38886,"idioma_id":4,"titulo":"OXIDATIVE STRESS, CELL CYCLE ARREST AND DIFFERENTIATION CONTRIBUTE TOWARD THE ANTIPROLIFERATIVE ACTION OF BSO AND CALCITRIOL ON CACO-2 CELLS","resumen":"Enviado: Wed, 19 Feb 2014 06:51:47 -0300 (ART)  Asunto: ACD Decision  Feb 19,     RE: ACD-2814R3, entitled 'OXIDATIVE STRESS, CELL CYCLE ARREST AND DIFFERENTIATION CONTRIBUTE TO THE ANTIPROLIFERATIVE ACTION OF BSO AND CALCITRIOL ON CACO-2 CELLS'    Dear Dr Picotto,  I am pleased to inform you that your work has now been accepted for publication in Anti-Cancer Drugs. All manuscript materials will be forwarded immediately to the production staff for placement in an upcoming issue.  OPEN ACCESS  If you indicated in the revision stage that you would like your submission, if accepted, to be made open access, please go directly to step 2. If you have not yet indicated that you would like your accepted article to be open access, please follow the steps below to complete the process:  1. Notify the journal office via email that you would like this article to be available open access. Please send your Email tom.sluyser@planet.nl. Please include your article title and manuscript number.  2. A License to Publish (LTP) form must be completed for your submission to be made available open access. Please download the form from http:\/\/links.lww.com\/LWW-ES\/A49, sign it, and Email the completed form to the journal office.  3. Go to http:\/\/wolterskluwer.qconnect.com to pay for open access. You will be asked for the following information. Please enter exactly as shown:  a. Article Title - OXIDATIVE STRESS, CELL CYCLE ARREST AND DIFFERENTIATION CONTRIBUTE TO THE ANTIPROLIFERATIVE ACTION OF BSO AND CALCITRIOL ON CACO-2 CELLS   b. Manuscript Number - ACD-2814R3  Thank you for submitting your interesting and important work to the journal.  http:\/\/acd.edmgr.com\/    Sincerely,  Dr Mels Sluyser   Editor  Anti-Cancer Drugs","palabras_clave":"1,25(OH)2D3,|D,L-buthionine-S,R-sulfoximine,|CACO-2 CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38887,"idioma_id":4,"titulo":"GLYCOSYLATION-DEPENDENT LECTIN-RECEPTOR INTERACTIONS PRESERVE ANGIOGENESIS IN ANTI-VEGF REFRACTORY TUMORS","resumen":"The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted therapies is variable, and tumors from treated patients eventually reinitiate growth. Here, we identify a glycosylation-dependent pathway that compensates for the absence of cognate ligand and preserves angiogenesis in response to VEGF blockade. Remodeling of the endothelial cell (EC) surface glycome selectively regulated binding of galectin-1 (Gal1), which upon recognition of complex N-glycans on VEGFR2, activated VEGF-like signaling. Vessels within anti- VEGF-sensitive tumors exhibited high levels of a2-6-linkedsialic acid,which prevented Gal1 binding. In contrast, anti-VEGF refractory tumors secreted increased Gal1 and their associated vasculature displayed glycosylation patterns that facilitated Gal1-ECinteractions. Interruption of b1-6GlcNAc branching in ECs or silencing of tumor-derived Gal1 converted refractory into anti-VEGF-sensitive tumors, whereas elimination of a2-6-linked sialic acid conferred resistance to anti-VEGF. Disruption of the Gal1-N-glycan axis promoted vascular remodeling, immune cell influx and tumor growth inhibition. Thus, targeting glycosylation-dependent lectin-receptor interactionsay increase the efficacy of anti-VEGF treatment.","palabras_clave":"Glycosylation|Angiogenesis|Galectin|Anti-VEGF Refractory Tumors"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38888,"idioma_id":4,"titulo":"Polymorphisms at the 3\u0002untranslated region of SLC11A1 geneare associated with protection to Brucella infection in goats","resumen":"Goats are susceptible to brucellosis and the detection of Brucella-infected animals is carriedout by serological tests. In other ruminant species, polymorphisms in microsatellites (Ms)of 3untranslated region (3UTR) of the solute carrier family 11 member A1 (SLC11A1) genewere associated with resistance to Brucella abortus infection. Goats present two polymor-phic Ms at the 3UTR end of SLC11A1 gene, called regions A and B. Here, we evaluated ifpolymorphisms in regions A and\/or B are associated with Brucella infection in goats. Serum(for the detection of Brucella-specific antibodies) and hair samples (for DNA isolation andstructure analysis of the SLC11A1 gene) were randomly collected from 229 adult native goatsfrom the northwest of Argentina. Serological status was evaluated by buffer plate antigentest (BPAT) complemented by the fluorescent polarization assay (FPA), and the genotype ofthe 3UTR of the SLC11A1 gene was determined by capillary electrophoresis and confirmedby sequence analysis. Polymorphisms in regions A and B of the 3UTR SLC11A1 gene werefound statistically significant associated with protection to Brucella infection. Specifically,the association study indicates statistical significance of the allele A15and B7\/B7genotypewith absence of Brucella-specific antibodies (p = 0.0003 and 0.0088, respectively). Thesedata open a promising opportunity for limiting goat brucellosis through selective breed-ing of animals based on genetic markers associated with natural resistance to B. melitensisinfection.","palabras_clave":"SLC11A1 gene|Goat|Brucellosis|Innate resistance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38889,"idioma_id":4,"titulo":"Local and regional long-term diversity changes and biotic homogenization in two temperate grasslands","resumen":"Questions: Are there losses in species richness due to extinctions? Is the input of new species lower in environments with strong resource limitation? Is there a decrease in abundance and diversity of native species due to anthropogenic disturbance at local and regional scale? Has abundance of exotic species been favoured by grazing increased? Are floristic changes associated with homogenization processes? Location: Two grassland community types of the Argentine Flooding Pampas: themesophyte prairie and the halophyte steppe. Methods: Grassland sites (n = 51) were resurveyed with the same methodology after 35 yr. At the local scale (0.25 ha),we analysed alpha diversity, site colonization and extinction rates, and changes in species and functional type composition. Site colonization rates were calculated separately for new species (not recorded in the original inventory) and old species (present in the first survey at other sample sites of the community). Correspondence analysis was applied to the presence\/absence species matrix for all sites in both periods. At regional scale, we evaluated gamma diversity, heterogeneity within and between communities, changes in proportion of functional types (growth season, longevity and life form) and species origin. Results: In themesophytic prairie, average local species richness increased 46% and regional richness 28%, while in the halophytic steppe changes were not significant. The colonization rate was higher and the extinction rate lower in the richest community (mesophytic prairie). Differences in colonization rates between natives and exotics were not found. Principal variability between sites in species composition was associated with abiotic conditions explaining 20.9% of inertia, temporal changes were relegated to the second axis with 6.38%. Proportions of warm-season exotics among newarrivalswere higher than expected. Biotic homogenization was evidenced in the mesophytic prairie as a significant reduction in species turnover between sampling dates. Conclusions: After 35 yr under moderate grazing intensity we found increases in species richness, no biodiversity loss and no losses of native species. Instead of those species favoured by grazing, as expected, warm season species increased. Different grassland communities showed clear differences in richness changes, in degree of homogenization and in species turnover.","palabras_clave":"PLANT DIVERSITY|HOMOGENIZATION|EXOTIC SPECIES|BETA DIVERSITY|FUNCTIONAL TYPES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38890,"idioma_id":4,"titulo":"From pattern to process: estimating expansion rates of a forest tree species in a protected palm savanna","resumen":"We assessed the possible influences of dominant tree density (Butia yatay palm trees) and fire on the expansion of a riparian tree population (Myrcianthes cisplatensis) over El Palmar National Park, a protected savanna in Argentina. Our approach is based on Skellam´s model of population expansion, which predicts that populations with density-independent reproduction and random dispersal will exhibit Gaussian-shaped expansion fronts. Using Poisson regression, we fitted Gaussian curves to Myrcianthes density data collected at varying distances from a riparian forest, within four environmental conditions resulting from combinations of palm density (dense and sparse) and fire history (burned and unburned). Based on the estimated parameters, we derived statistics appropriate to compare attained expansion velocity, mean squared effective dispersal distance, and density-independent population growth among environmental conditions. We also analyzed the effects of palm density, fire history, and distance from the riparian forest on local maximum size of Myrcianthes individuals. Gaussian curves fitted the data reasonably well and slightly better than two alternative front models. Palm density and fire history interacted to control Myrcianthes spread, making unburned dense palm savannas the preferential avenue for Myrcianthes population expansion across the landscape. Limitation of Myrcianthes expansion by fire appeared to result from low survival of small individuals to fire, whereas facilitation of Myrcianthes expansion by palm trees may have resulted from increased population growth. Our results stress the interactive role of fire regime and local biotic influences in determining propagule pressure and tree establishment at the forefront, and the overall vulnerability of savannas to colonization by forest species.","palabras_clave":"GRASSLAND FOREST BOUNDARY|INVASIBILITY|INVERSE MODELLING|POPULATION EXPANSION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38891,"idioma_id":5,"titulo":"Las comunidades vegetales de la sabana del Parque Nacional El Palmar (Argentina)","resumen":"El Parque Nacional El Palmar, Entre Ríos, preserva desde 1965 el mayor remanente de la sabana deButia yatay, un ecosistema rico en especies amenazado por la actividad humana. Para estudiar el funcionamientode este ecosistema y gestionar su preservación, es necesario contar con una adecuada caracterizaciónde la heterogeneidad de su vegetación. En este trabajo presentamos una clasificación fitosociológicade las comunidades vegetales de la sabana del Parque, describimos su estructura, composición y diversidad florística y detallamos su distribución en el paisaje. Con el fin de estratificar la obtenciónde datos, delimitamos primero las principales unidades geomorfológicas del paisaje. En la primaverade 1999 y en el verano siguiente, realizamos censos florísticos completos en 73 ?stands? de sabana condiferentes historias de incendio, distribuidos en las diferentes unidades geomorfológicas. Utilizamostécnicas de análisis multivariado y clasificación numérica para agrupar los censos en comunidades y lasespecies en grupos florísticos. Finalmente, resumimos las diferencias entre las comunidades en un escalamientomultidimensional métrico. Obtuvimos 7 comunidades, descriptas por 20 grupos florísticos. Elpatrón de similitudes entre estas comunidades sugiere que la heterogeneidad florística se ordena segúndos componentes, uno asociado con diferencias en la textura del suelo y el otro con diferencias en elrégimen de humedad del suelo. Tres de las comunidades, afines entre sí, se distribuyen en las terrazasaltas e interfluvios que conforman la matriz del paisaje, en correspondencia con diferencias graduales detopografía y suelos. Estas comunidades cambian sucesionalmente por el avance de la lignificación desencadenadapor la exclusión del ganado y mantenida por la escasez de incendios naturales. Las restantescuatro comunidades aparecen estrictamente asociadas con afloramientos rocosos, depósitos arenososo vías de escurrimiento que interrumpen la matriz del paisaje; en ellas no es evidente la lignificación.","palabras_clave":"Fitosociología"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38892,"idioma_id":4,"titulo":"Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses","resumen":"Aquaporins (AQPs) are a family of channel proteins, which transport water and\/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165-176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells.","palabras_clave":"aquaporin|evolution|function|integration"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38893,"idioma_id":4,"titulo":"In  vitro  and  in  vivo  assessment  of  the  benzydamine-mediated interference  with  the  hepatic  S-oxidation  of  the  anthelmintic albendazole  in  sheep","resumen":"The aim of this research was to investigate the influence of benzydamine (BZ) on the in vitro and in vivo hepatic metabolism of the anthelmintic albendazole (ABZ) in sheep. The enantioselective ABZ S-oxidation was assessed by the amount of its (-) and (+) ABZ-sulphoxide (ABZSO) enantiomers formed in sheep liver microsomes (in vitro work). In the in vivo trial, lambs received ABZ (5mg\/kg, intra-ruminal route) or ABZ (5mg\/kg) plus BZ (8mg\/kg, i.m., two doses 4h apart). Incubated and plasma samples were analysed by HPLC. In vitro, BZ IC50s (the concentrations that produced a 50% decrease in ABZ S-oxidation) for the production of total ABZSO and (+)ABZSO were 71.0±8.1 and 62.6±8.1&#956;M, respectively. BZ showed a strong inhibitory potency over the flavin-monooxygenase (FMO)-dependent production of (+)ABZSO compared to the cytochrome P450 (CYP)-mediated production of (-)ABZSO. In vivo, co-administration of BZ with ABZ did not change the pharmacokinetic parameters of ABZSO and ABZSO2 with the exception of significantly higher (p&lt;0.01) formation half-lives (t1\/2for) for (-)ABZSO (3.24±1.03h vs. 6.19±2.18h) and (+)ABZSO (3.87±1.20h vs. 7.21±2.46h). BZ inhibited the hepatic FMO and CYP-dependent S-oxidation of ABZ in vitro. However, the metabolic interaction between ABZ and BZ was not observed in the in vivo pharmacokinetic trial. Hence, further work using a different dosing scheme or pharmaco-technical preparation of BZ may be required to observe in vivo the metabolic interference clearly shown under in vitro conditions.","palabras_clave":"ALBENDAZOLE|BENZYDAMINE|BIOTRANSFORMATION|SHEEP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38894,"idioma_id":4,"titulo":"Closantel plasma and milk disposition in dairy goats: assessment of drug residues in cheese and ricotta","resumen":"            Closantel  (CLS) is currently used in programs for the strategic control of  gastrointestinal nematodes. CLS is extralabel used in different dairy goat  production systems. From available data in dairy cows, it can be concluded that  residues of CLS persist in milk. The current work evaluated the concentration profiles  of CLS in plasma and milk from lactating orally treated dairy goats to assess  the residues pattern in dairy products such as cheese and ricotta. Six (6)  female Saanen dairy goats were treated orally with CLS administered at 10  mg\/kg. Blood and milk samples were collected between 0 and 36 days post-treatment.  The whole milk production was collected at 1, 4, 7, and 10 days post-treatment  to produce soft cheese and ricotta. CLS concentrations in plasma, milk, cheese,  whey, and ricotta were determined by HPLC. The concentrations of CLS measured  in plasma were higher than those measured in milk at all sampling times. However,  the calculated withdrawal time for CLS in milk was between 39 and 43 days postadministration  to dairy goats. CLS residual concentrations in cheese (between 0.93 and 1.8 &#956;g\/g)  were higher than those measured in the milk used for its production. CLS concentrations  in ricotta were sixfold higher than those in the milk and 20-fold higher than  those in the whey used for its production. The persistent and high residual  concentrations of CLS in the milk and in the cheese and ricotta should be  seriously considered before issuing any recommendation on the extralabel use of  CLS in dairy goat farms.  ","palabras_clave":"CLOSANTEL|RESIDUES|MILK|GOAT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38895,"idioma_id":4,"titulo":"Intestinal drug transport: ex vivo evaluation of the interactions between  ABC transporters and anthelmintic molecules","resumen":"The family of ATP-binding cassette (ABC) transporters is composed of several transmembrane proteins that are involved in the efflux of a large number of drugs including ivermectin, a macrocyclic lactone (ML) endectocide, widely used in human and livestock antiparasitic therapy. The aim of the work reported here was to assess the interaction between three different anthelmintic drugs with substrates of the P-glycoprotein (P-gp) and the breast cancer resistance protein (BCRP). The ability of ivermectin (IVM), moxidectin (MOX) and closantel (CST) to modulate the intestinal transport of both rhodamine 123 (Rho 123), a P-gp substrate, and danofloxacin (DFX), a BCRP substrate, across rat ileum was studied by performing the Ussing chamber technique. Compared to the controls, Rho 123 efflux was significantly reduced by IVM (69%), CST (51%) and the positive control PSC833 (65%), whereas no significant differences were observed in the presence of MOX (30%). In addition, DFX efflux was reduced between 59% and 72% by all the assayed drug molecules, showing a higher potency than that observed in the presence of the specific BCRP inhibitor pantoprazole (PTZ) (52%). An ex vivo intestinal transport approach based on the diffusion chambers technique may offer a complementary tool to study potential drug interactions with efflux transporters such as P-gp and BCRP.","palabras_clave":"intestinal drug transport|ABC transporters|anthelmintics|ex vivo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38896,"idioma_id":4,"titulo":"Oxfendazole flukicidal activity in pigs","resumen":"Although oxfendazole (OFZ) is a well know broad-spectrum benzimidazole anthelmintic, the assessment of its potential trematodicidal activity remains unexplored. OFZ administration at single high doses has been recommended to control Taenia solium cysticercus in pigs. The current study investigated the flukicidal activity obtained after a single high (30mg\/kg) oral dose of OFZ in pigs harbouring a natural Fasciola hepatica infection. Sixteen (16) local ecotype pigs were randomly allocated into two (2) experimental groups of 8 animals each named as follow: Untreated control and OFZ treated, in which animals received OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30mg\/kg. At seven (7) days post-treatment, all the animals were sacrificed and direct adult liver fluke counts were performed following the WAAVP guidelines. None of the animals involved in this experiment showed any adverse event during the study. OFZ treatment as a single 30mg\/kg oral dose showed a 100% efficacy against F. hepatica. In conclusion, the trial described here demonstrated an excellent OFZ activity against F. hepatica in naturally infected pigs, after its administration at a single oral dose of 30mg\/kg. © 2014 Elsevier B.V.","palabras_clave":"Oxfendazole|flukicidal|activity|pigs"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38897,"idioma_id":4,"titulo":"Symbolic Data Analysis: A Paradigm for Complex Data Mining?","resumen":"Standard   data mining techniques no longer adequately represent the complexity of   the world. So, a new paradigm is necessary. Symbolic Data Analysis is a   new type of data analysis that allows us to represent the complexity of   reality, maintaining the internal variation and structure developed by   Diday (2003). This new paradigm is based on the concept of symbolic   object, which is a mathematical model of a concept. In this article the   authors are going to present the fundamentals of the symbolic data   analysis paradigm and the symbolic object concept. Theoretical aspects   and examples allow the authors to understand the SDA paradigm as a tool   for mining complex data.","palabras_clave":"Symbolic Data Analysis|Complex Data mining|Symbolic Object"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38898,"idioma_id":4,"titulo":"-\tNatural enemies of Atta vollenweideri leafcutter ants negatively affected by synthetic pesticides chlorpyrifos and fipronil.","resumen":"In southern South America, Atta vollenweideri Forel (Hymenoptera:   Formicidae) is a significant pest of several crops and forestry, also   considered to reduce the carrying capacity of pastures. The most usual   control method used in Latin America is the application of synthetic   pesticides, mainly chlorpyrifos and fipronil. However, no studies have   assessed the effects of these agrochemicals on natural enemies of ants.   We aimed to evaluate the efficiency of these pesticides on leaf-cutter   ants´ control and to test their effect on phorid fly parasitoids.   Chlorpyrifos failed to exert complete control over ant colonies in the   field and was gravely detrimental to specific parasitoids, reducing   their percentage of parasitism, pupal survivorship, and adult longevity.   Fipronil, however, exerted complete control over the treated colonies.   Laboratory tests using both pesticides, either on ants from foraging   trails or on pupariae, showed that chlorpyrifos and fipronil decreased   larval and pupal survivorship, as well as adult longevity of   parasitoids, in comparison to controls. In conclusion, these pesticides   will likely affect parasitoids with regard to their reproductive   capacity, leading to the decreased levels of natural parasitism observed   in the field after treatments. We discuss why neither pesticide should   be taken into account for integrated pest management programs.","palabras_clave":"PHORIDAE|LEAFCUTTER ANT|CHLORPYRIFOS|FIPRONIL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38899,"idioma_id":4,"titulo":"Endosulfan leaching from Typic Argiudolls in soybean tillage areas and groundwater pollution implications","resumen":"Endosulfan has been recently added to Persistent Organic Pollutants (POPs) list and due to its extensive and massive use and environmental persistence constitutes a potential hazard to groundwater resources. Undisturbed soil columns were used to evaluate endosulfan leaching in two series of Typic Argiudolls considering natural and agricultural land use. Columns were spiked with 10 &#956;g L&#8722;1 of technical endosulfan and eluted under saturated flowwith five pore volumes of distilledwater. Alfa and beta isomer residueswere detected in the upper soil level, with decreasing values through the profile, being influenced by soil texture and land use. The endosulfan sulfate metabolite was mainly found in the upper level linked to high dehydrogenase activity. Results from leachates (total endosulfan 27?87 ng L&#8722;1) showed higher &#945;-isomer mobility, and suggest alkaline hydrolysis of both endosulfan isomers. The agricultural use modified the physico-chemical properties and structure of soils leading to vertical migration of endosulfan isomers under saturated conditions. Intact column test provided information close to field data showing its utility for the assessment of groundwater pollution by endosulfan.","palabras_clave":"Intact column test|Groundwater pollution| Endosulfan | Argiudolls"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38900,"idioma_id":4,"titulo":"A DFT study of cyclopropane adsorption on Pt(1 1 1). Electronic structure and   Bonding","resumen":"              We have studied the adsorption of cyclopropane  (c-C3H6) on Pt(1 1 1) by means of the density functional theory  (DFT). We have investigated the preferential adsorption geometry, considering  different adsorption sites and bonding configurations for the molecular  adsorbate. We have also computed the electronic structure and bonding  interactions by means of density of states (DOS), crystal orbital overlap  population (OPDOS), and overlap population (OP) analysis.  Our results show a small preference for Bridge and Top adsorption sites with  the cyclopropane ring parallel to the surface. Pt-C equilibrium distance is about 3.5 Å and a weak bond is formed during adsorption. The main bonding  interaction comes from the Pt-H overlap population. Pt 5pz orbitals  play an important role in the bonding between c-C3H6 and  the surface. We have found that Van der Waals (vdW) corrections to the energies  improve the adsorption values without changing the preferential site geometries.  ","palabras_clave":"Pt(1 1 1)|ADSORPTION|CYCLOPROPANE|DFT|BONDING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38901,"idioma_id":5,"titulo":"Protección del acero con pinturas con sales de tierras raras como pigmentos anticorrosivos","resumen":"...","palabras_clave":"ZEOLITAS|PIGMENTOS ANTICORROSIVOS|TIERRAS RARAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38902,"idioma_id":4,"titulo":"L925I mutation in the Para-type sodium channel is associated with pyrethroid resistance in Triatoma infestans from the Gran Chaco region","resumen":"One of the principal goals of the Southern Cone Initiative  (SCI), created in 1991, is to reduce the geographic range  and infestation prevalence of triatomines, vectors of  Chagas?disease. Despite its success in many areas, the  elimination of Triatoma infestans has failed in the Gran  Chaco ecoregion, even in areas subjected to intense vector  control efforts with pyrethroid insecticides. Detecting the  reasons for the persistence of T. infestans in the Gran  Chaco has been recognized as a priority of the SCI, in its  15th meeting held in Brasilia in 2006. The voltage -  dependent sodium channel is the target protein of  pyrethroid insecticides. In this work, we investigated  possible mutations in the sodium channel gene in a highly  resistant population from Gran Chaco. We found a point  mutation that affects the structure of the channel and is  associated with high resistance to pyrethroids. We also  present a simple and low-cost method to detect this  mutation in individuals from the field. Our results are  important for monitoring the presence and spread of  pyrethroid-resistant populations of T. infestans, a critical  requirement in the implementation of strategies for  resistance management and for the rational design of  campaigns oriented to controlling the transmission of  Chagas? disease.","palabras_clave":"CHAGA'S DISEASE|VOLTAGE-GATED SODIUM CHANNEL|KNOCKDOWN RESISTANCE (kdr)"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38903,"idioma_id":4,"titulo":"A setting for generalized orthogonalization","resumen":"Let H be a complex Hilbert space. We study the geometry of thespace of pairs (A,E), for A a (semidefinite bounded linear) positive operatoron H and E a (bounded linear) projection on H such that AE = EA.","palabras_clave":"PROYECCIONES A-AUTOADJUNTAS|OPERADORES POSITIVOS|PROYECCIONES ORTOGONALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38904,"idioma_id":4,"titulo":"Procrustes problems and Parseval quasi-dual frames","resumen":"Parseval frames have particularly useful properties, and in some cases, they can be used to reconstruct signals which were analyzed by a non-Parseval frame. In this paper, we completely describe the degree to which such reconstruction is feasible.   Indeed, notice that for fixed frames $cF$ and $cX$ with synthesis operators $F$ and $X$, the operator norm of $FX^*-I$ measures the (normalized) worst-case error in the reconstruction of vectors when analyzed with $cX$ and synthesized with $cF$. Hence, for any given frame $cF$, we compute explicitly the infimum of the operator norm of $FX^*-I$, where $cX$ is any Parseval frame. The $cX$´s that minimize this quantity are called Parseval quasi-dual frames of $cF$. Our treatment considers both finite and infinite Parseval quasi-dual frames.","palabras_clave":"Procustes problems|Parseval frames|Dual frames"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38905,"idioma_id":4,"titulo":"Expression of Animal Anti-Apoptotic Gene Ced-9 Enhances Tolerance during Glycine max L.? Bradyrhizobium japonicum Interaction under Saline Stress but Reduces Nodule Formation","resumen":"The mechanisms by which the expression of animal cell death suppressors in economically important plants conferredenhanced stress tolerance are not fully understood. In the present work, the effect of expression of animal antiapoptoticgene Ced-9 in soybean hairy roots was evaluated under root hairs and hairy roots death-inducing stress conditions given byi) Bradyrhizobium japonicum inoculation in presence of 50 mM NaCl, and ii) severe salt stress (150 mM NaCl), for 30 min and3 h, respectively. We have determined that root hairs death induced by inoculation in presence of 50 mM NaCl showedcharacteristics of ordered process, with increased ROS generation, MDA and ATP levels, whereas the cell death induced by150 mM NaCl treatment showed non-ordered or necrotic-like characteristics. The expression of Ced-9 inhibited or at leastdelayed root hairs death under these treatments. Hairy roots expressing Ced-9 had better homeostasis maintenance,preventing potassium release; increasing the ATP levels and controlling the oxidative damage avoiding the increase ofreactive oxygen species production. Even when our results demonstrate a positive effect of animal cell death suppressors inplant cell ionic and redox homeostasis under cell death-inducing conditions, its expression, contrary to expectations,drastically inhibited nodule formation even under control conditions.","palabras_clave":"Anti-Apoptotic Gene|saline stress"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38906,"idioma_id":4,"titulo":"Assessing the energetic costs and trade-offs of a PHA- induced inflammation in the subterranean rodent Ctenomys talarum: Immune response in growing tuco-tucos","resumen":"      A traditional  approach used to assess whether immune defense is costly is to explore the  existence of trade-offs between immunity and other functions; however,  quantitative studies of the energetic Costs associated with the activation of  the immune system are scarce. We assessed the magnitude of a PHA-triggered  immune response and the associated energetic costs in 60-day old Ctenomys  talarum. We expected  that the magnitude of the macroscopic inflammatory response to PHA is lower in  young tuco-tucos compared with that of adults, given the allocation of  substantial energy to growth, and that the magnitude of the inflammation is  lower in male pups compared to females, due to the higher investment in growth  of the larger sex. Concomitantly, we expected that the pups challenged with PHA  show an increase in oxygen consumption compared to control animals and that a  positive association exists between magnitude of the PHA-induced inflammation  and oxygen consumption. Contrary to what was expected, young tuco-tucos mounted  a higher inflammatory response compared with adults and there were no  differences in the magnitude of this response between sexes. The inflammatory  response induced by a PHA injection did not represent a significant energetic  cost for young tuco-tucos. There were no differences in oxygen consumption between  PHA-injected and control animals, and tuco-tucos that mounted a higher  inflammatory response to PHA did not show higher oxygen consumption. Energy  expenditure, however, is not the only physiological cost involved in trade-offs  between immune response and various functions of the organism, and other  currencies are discussed.  ","palabras_clave":"GROWTH|MATURATION|SUBTERRANEAN|CELL-MEDIATED"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38907,"idioma_id":4,"titulo":"Global population structure and evolution of Bordetella pertussis and their relationship with vaccination","resumen":"...","palabras_clave":"BORDETELLA PERTUSSIS|VACCINATION|POPULATION STRUCTURE|EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38908,"idioma_id":4,"titulo":"Modelling the effect of changes in vaccine effectiveness and transmission contact rates on pertussis epidemiology","resumen":"The incidence of the highly infectious respiratory   disease named pertussis or whooping cough has been increasing for the   past two decades in different countries, as in much of the highly   vaccinated world. A decrease in vaccine effectiveness over time,   especially when acellular vaccines were used for primary doses and   boosters, and pathogen adaptation to the immunity conferred by vaccines   have been proposed as possible causes of the resurgence. The   contributions of these factors are not expected to be the same in   different communities, and this could lead to different epidemiological   trends. In fact, differences in the magnitude and dynamics of pertussis   outbreaks as well as in the distribution of notified cases by age have   been reported in various regions.        Using an   age-structured mathematical model designed by us, we evaluated how the   changes in some of the parameters that could be related to the above   proposed causes of disease resurgence ? vaccine effectiveness and   effective transmission rates ? may impact on pertussis transmission.        When   a linear decrease in vaccine effectiveness (VE) was assayed, a   sustained increase in pertussis incidence was detected mainly in infants   and children. On the other hand, when changes in effective transmission   rates (&#946;ij) were made, a dynamic effect   evidenced by the presence of large peaks followed by deep valleys was   detected. In this case, greater incidence in adolescents than in   children was observed. These different trends in the disease dynamics   due to modifications in VE or &#946;ij were   verified in 18 possible scenarios that represent different   epidemiological situations. Interestingly we found that both incidence   trends produced by the model and their age distribution resemble the   profiles obtained from data reported in several regions. The   implications of these correlations are discussed.","palabras_clave":"PERTUSSIS|TRANSMISSION|MATHEMATICAL MODEL|OUTBREAKS|EPIDEMIOLOGICAL TRENDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38909,"idioma_id":5,"titulo":"'ISOTERMAS DE ADSORCIÓN Y DESORCIÓN DE AGUA EN LECHE EN POLVO: II. LECHE ENTERA'","resumen":"El objetivo de este trabajo fue determinar las isotermas de adsorción y desorción de agua sobre leche de vaca en polvo entera. Se realizaron las experiencias a 15, 25 y 40ºC, en un rango de humedades y actividades de agua propias de las condiciones habituales en que se desarrollan los procesos de secado, envasado y almacenamiento. Se determinó el calor isostérico de adsorción estudiando la influencia de la temperatura sobre las curvas obtenidas. Los datos experimentales se correlacionaron con el modelo referencial de Guggenheim, Anderson y de Boer (GAB). Tanto para la adsorción como para la desorción se observó un buen ajuste del modelo. Las isotermas presentaron formas muy similares entre si y se comprobó el fenómeno de histéresis al comparar las isotermas de adsorción con las de desorción.","palabras_clave":"ACTIVIDAD DE AGUA|ISOTERMA|LECHE ENTERA|CALOR ISOSTÉRICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38910,"idioma_id":4,"titulo":"Cultivating the dry forests of South America: Diversity of land users and imprints on ecosystem functioning","resumen":"In   the South American dry forest of the Dry Chaco and Chiquitania, the area   under cultivation rose from 10% to 19% over the last ten years, and   little biophysical, economical, or political constrains seem to prevent   further expansion. Although typically associated to a homogeneous   agribusiness system, agriculture and its expansion in this territory   involve a diverse array of land users. Here we (i) identified and mapped   the most conspicuous groups of land users based on existing scientific   literature and technical reports, and (ii) described their associated   landscape pattern and (iii) vegetation functioning based on different   remote sensing tools applied to a set of 218 sample points. We   recognized 14 groups of land users of local or foreign origin, composed   by individuals or corporative organizations, and dedicated either to   pasture or crop production, or its combination. These groups displayed a   wide variation in the scale of their operations as suggested by a   60-fold difference in paddock sizes. Twelve years of MODIS-NDVI data   showed small and non-significant differences in the magnitude of primary   productivity (1.2 fold-difference) but strong contrasts in its   seasonality and long-term variability, including shifts in the rates of   vegetation greening and browning (up to 4 fold-differences), growing   period length (193 to 278 days y-1), number of cultivation seasons per   year (1 to 1.75), and inter-annual coefficient of variation (up to   0.13). Agriculture under capitalized groups was characterized by very   large paddocks, less stable productivity patterns, and more divergent   seasonality. Instead, all smallholders showed more stable productivities   both seasonally and inter-annually. Deforestation and cultivation in   these dry regions does not have a single imprint on landscapes   configuration and primary production dynamics, but one that shifts   depending on the human and productive context under which they take   place.","palabras_clave":"dry forest of the Dry Chaco and Chiquitania|landscape pattern| vegetation functioning|land users|deforestation and cultivation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38911,"idioma_id":4,"titulo":"Tissue distribution of Cd, Cu, Zn, Ni, Cr, Pb and Hg in Striated Heron Butorides striatus (Aves: Ardeidae) in a fluvial ecosystem","resumen":"In this study, the striated heron (Butorides striatus), a species that reproduces in the Middle Paraná River floodplain, was examined for lead, cadmium, chromium, zinc, nickel, mercury and copper concentrations, using liver, kidney, muscle, vertebra and feathers. The results showed low exposure to chromium because all tissue samples had concentrations below the limit of detection. Similar results were obtained for nickel and lead, with the exception of vertebra. This might be associated with either long-term exposure to thesemetals, or it may be that both nesting and wintering areas are non-polluted. Zinc and copper, both essential metals, were found in all tissues and their concentrations were within the ranges reported in the literature.Mercury was also found in all tissues, but at very low concentrations and even at concentrations below those that produce negative effects in several species of birds (e.g. reproductive success, food intake). Studies of this type are needed to interpret the role of organisms within environments impacted by different human activities.","palabras_clave":"HEAVY METALS|HERONS|BUTORIDES STRIATUS|MIDDLE PARANA RIVER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38912,"idioma_id":4,"titulo":"Antioxidant and antiapoptotic properties of melatonin restore intestinal calcium absorption altered by menadione","resumen":"The intestinal Ca2+ absorption is inhibited by  menadione (MEN) through oxidative stress and apoptosis.  The aim of this study was to elucidate whether the antioxidant  and antiapoptotic properties of melatonin (MEL)  could protect the gut against the oxidant MEN. For this  purpose, 4-week-old chicks were divided into four groups:  (1) controls, (2) treated i.p. with MEN (2.5 lmol\/kg of  b.w.), (3) treated i.p. with MEL (10 mg\/kg of b.w.), and (4)  treated with 10 mg MEL\/kg of b.w after 2.5 lmol MEN\/kg  of b.w. Oxidative stress was assessed by determination of  glutathione (GSH) and protein carbonyl contents as well as  antioxidant enzyme activities. Apoptosis was assayed by  the TUNEL technique, protein expression, and activity of  caspase 3. The data show that MEL restores the intestinal  Ca2+ absorption altered by MEN. In addition, MEL  reversed the effects caused by MEN such as decrease in  GSH levels, increase in the carbonyl content, alteration in  mitochondrial membrane permeability, and enhancement  of superoxide dismutase and catalase activities. Apoptosis  triggered by MEN in the intestinal cells was arrested by  MEL, as indicated by normalization of the mitochondrial  membrane permeability, caspase 3 activity, and DNA  fragmentation. In conclusion, MEL reverses the inhibition  of intestinal Ca2+ absorption produced by MEN counteracting  oxidative stress and apoptosis. These findings suggest  that MEL could be a potential drug of choice for the  reversal of impaired intestinal Ca2+ absorption in certain  gut disorders that occur with oxidative stress and apoptosis.","palabras_clave":"MELATONIN|CALCIUM ABSORPTION|APOPTOSIS|OXIDATIVE STRESS|MENADIONE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38913,"idioma_id":4,"titulo":"Environmental Enrichment Protects The Retina From Early Diabetic Damage In Adult Rats","resumen":"        Diabetic retinopathy is  a leading cause of reduced visual acuity and acquired blindness. Available  treatments are not completely effective. We analyzed the effect of environmental  enrichment on retinal damage induced by experimental diabetes in adult Wistar rats. Diabetes was induced by an  intraperitoneal injection of streptozotocin. Three days after vehicle or streptozotocin  injection, animals were housed in enriched environment or remained in a standard  environment. Retinal function (electroretinogram, and oscillatory potentials), retinal  morphology, blood-retinal barrier integrity, synaptophysin, astrocyte and  Müller cell glial fibrillary acidic protein, vascular endothelial growth factor,  tumor necrosis factor-&#945;, and brain-derived neurotrophic factor levels, as well  as lipid peroxidation were assessed in retina from diabetic animals housed in standard  or enriched environment. Environmental enrichment preserved scotopic electroretinogram  a-wave, b-wave and oscillatory potential amplitude, avoided albumin-Evan´s blue  leakage, prevented the decrease in retinal synaptophysin and astrocyte glial  fibrillary acidic protein levels, the increase in Müller cell glial fibrillary  acidic protein, vascular endothelial growth factor and tumor necrosis factor-&#945;  levels, as well as oxidative stress induced by diabetes. In addition, enriched  environment prevented the decrease in retinal brain-derived neurotrophic factor  levels induced by experimental diabetes. When environmental enrichment started  7 weeks after diabetes onset, retinal function was significantly preserved. These  results indicate that enriched environment could attenuate the early diabetic  damage in the retina from adult rats.  ","palabras_clave":"Diabetes|Retina|Enriched Environment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38914,"idioma_id":4,"titulo":"Maize forage aptitude: combining ability of inbred lines and stability of hybrids.","resumen":"Abstract  Breeding of forage maize should combine improvement achieved for grain with the specific needs of forage hybrids. Production stability is important when maize is used for silage if the planting area is not in the ideal agronomic environment. The objectives of the present research were: (i) to quantify environmental and genetic and their interaction effects on maize silage traits; (ii) to identify possible heterotic groups for forage aptitude and suggest the formation of potential heterotic patterns, and (iii) to identify suitable inbred line combinations for producing hybrids with forage aptitude. Forty-five hybrids derived from diallelic crosses (without reciprocals) among ten inbred lines of maize were evaluated in this study. Combined ANOVA over environments showed differences between genotypes (G), environments (E), and their interactions (GEI). Heritability (H2), and genotypic and phenotypic correlations were estimated to evaluate the variation in and relationships between forage traits. Postdictive and predictive AMMI models were fitted to determine the importance of each source of variation, G, E, and GEI, and to select genotypes simultaneously on yield, quality and stability. A predominance of additive effects was found in the evaluated traits. The heterotic pattern Reid-BSSS × Argentine flint was confirmed for ear yield (EY) and harvest index (HI). High and broad genetic variation was found for stover and whole plant traits. Some inbred lines had genes with differential breeding aptitude for ear and stover. Stover and ear yield should be the main breeding objectives in maize forage breeding.","palabras_clave":"MAIZE|FORAGE|ABILITY|STABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38915,"idioma_id":4,"titulo":"Dynamics and reliability of bistable neurons driven with time-dependent stimuli","resumen":"The reliability of a spiking neuron depends on the frequency content of the driving input signal. Previous studies have shown that well above threshold, regularly firing neurons generate reliable responses when the input signal resonates with the firing frequency of the cell. Instead,  well below threshold, reliable responses are obtained when the input frequency resonates with the subthreshold oscillations of the neuron. Previous theories, however, provide no clear prediction for the input frequency giving rise to maximally reliable spiking at threshold, which is probably the most relevant firing regime in mammalian cortex under physiological conditions.  In particular, when the firing onset is governed by a subcritical Hopf bifurcation, the frequency  of subthreshold oscillations often differs from the firing rate at threshold. The predictions of previous studies, hence, cannot be smoothly merged at threshold. Here we explore the behavior of reliability in bistable neurons near threshold using three types of driving stimuli: constant, periodic and stochastic. We find that the two natural frequencies of the system, associated to the two coexisting attractors, provide a rich variety of possible locking modes with the external  signal. Reliability is determined by the sensitivity to noise of each locking mode, and also by the transition probabilities between modes. Noise increases the amount of spike-time jitter, and minimal jitter is obtained for input frequencies coinciding with the suprathreshold firing  rate of the cell. In addition, noise may either enhance or inhibit transitions between the two attractors, depending on the input frequency. The dual role played by noise in bistable systems implies that reliability is determined by a delicate balance between spike-time jitter and the rate of transitions between attractors.","palabras_clave":"RELIABILITY|BISTABLE NEURONS|TYPE II MORRIS LECAR|DYNAMICAL SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38916,"idioma_id":4,"titulo":"Versatile Supramolecular Organogel with Outstanding Stability  toward Aqueous Interfaces","resumen":"In this communication we report on a novel and versatile low molecular weight organogelator. The methanolic gel exhibits an exceptional water-enhanced stability as evidenced by a 30oC increase in Tg with up to 10 %v\/v of water. This atypical property not observed with other solvents makes of this supramolecular gel a highly stable matrix compatible with aqueous interfaces. As a proof of principle we present the sensing performance of a symmetric tricarbocyanine fluorophore bearing a Zn(II)chelator unit. The system retained its remarkable physical integrity for a long period of time opening new possibilities for other organic-aqueous interface applications.","palabras_clave":"organogel|tricarbocyanine|aqueous interface|fluorescence"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38917,"idioma_id":4,"titulo":"Bacterial Community Structure in Patagonian Andean Lakes Abov e and Below Timberline: From Community Composition to Community Function","resumen":"Lakes located above the timberline are remote systems with anumber of extreme environmental conditions, becoming physicallyharsh ecosystems, and sensors of global change. We analyzebacterial community composition and community-levelphysiological profiles in mountain lakes located in an altitudegradient in North Patagonian Andes below and above thetimberline, together with dissolved organic carbon (DOC)characterization and consumption. Our results indicated a decreasein 71 % of DOC and 65 % in total dissolved phosphorus (TDP)concentration as well as in bacteria abundances along the altituderange (1,380 to 1,950 m a.s.l.). Dissolved organic matter (DOM)fluorescence analysis revealed a low global variability composedby two humic-like components (allochthonous substances) and asingle protein-like component (autochthonous substances). Lakesbelow the timberline showed the presence of all the threecomponents, while lakes above the timberline the protein-likecompound constituted the main DOC component. Furthermore,bacterial community composition similarity and ordination analysisshowed that altitude and resource concentration (DOC and TDP)were the main variables determining the ordination of groups.Community-level physiological profiles showed a mismatch withbacteria community composition (BCC), indicating the absence of arelationship between genetic and functional diversity in the altitudegradient. However, carbon utilization efficiencies varied accordingto the presence of different compounds in DOM bulk. The obtainedresults suggest that the different bacterial communities in thesemountain lakes seem to have similar metabolic pathways in orderto be able to exploit the available DOC molecules.","palabras_clave":"Lagos de montaña|Materia orgánica disuelta|Respiración bacteriana|Diversidad Biológica y funcional"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38918,"idioma_id":4,"titulo":"Ni-Cu\/Ce0.9Zr0.1O2 bimetallic Cermets for electrochemical and catalytic applications","resumen":"The development of an economically feasible Solid Oxide Fuel Cell technology has driven  the research activity in this area toward the reduction of their operating temperature. New  anode materials, with high electrocatalytic activity and resistance to coke deposition when  hydrocarbons are used as fuel, have to be developed. The aim of this paper is to give a  contribution in this area by studying the effect of Ni substitution by Cu in the NiO (60 wt.%)\/  Ce0.9Zr0.1O2 cermet recently proposed as a possible anode material.  It was observed that the partial replacement of Ni by Cu has produced solids with high  reducibility, excellent catalytic and electrocatalytic performances and higher resistance to  carbon deposition in the operation with CH4.","palabras_clave":"CeO2-ZrO2|IT-SOFCs|ANODES|ELECTROCATALYTIC ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38919,"idioma_id":4,"titulo":"A NEW SEMI-SYNTHETIC DERIVATIVE OF SAUROINE INDUCES LTP IN HIPPOCAMPAL SLICES AND IMPROVES LEARNING PERFORMANCE IN THE MORRIS WATER MAZE","resumen":"Abstract  Two semisynthetic acetyl derivatives of the alkaloid sauroine  from Huperzia saururus, monoacetyl sauroine, and diacetyl  sauroine (DAS) were obtained and their chemical structures  were analyzed by NMR. While monoacetyl sauroine is the  typical product of acetylation, DAS is an unexpected derivative  related to the keto-enol formation of sauroine. Recordings of  field excitatory post-synaptic potentials from the CA1 region of  rat hippocampal slices showed that only DAS acutely  applied induced chemical long-term potentiation (LTP) in a  dose-dependent manner with an EC50 of 1.15 _ 0.09 lM. This  effectwasblockedby10 lMD(-)-2-amino-5-phosphonopentanoic  acid (AP5), suggesting dependence on the NMDA receptor.  DAS significantly increased NMDA receptor-dependent  excitatory post-synaptic currents without affecting a-amino-  3-hydroxy-5-methylisoxazole-4-propionate receptor-dependent  currents. Repetitive administration of DAS improved visuospatial  learning in the Morris Water Maze. In slices from  rats tested in the Morris Water Maze, LTP resulting from  electrical synaptic stimulation was 2.5 times larger than in  controls. Concentration of DAS measured in the brain after  repetitive administration was 29.5 lM. We conclude that slices  perfused with DAS display a robust NMDA receptor-dependent  chemical LTP. During chronic treatment, DAS enhances  learning abilities through a metaplastic mechanism as  revealed by the augmentation of LTP in slices. DAS, therefore,  may be a promising compound as a nootropic therapeutic  drug. Keywords: learning and memory, long-term potentiation,  lycopodium alkaloids, metaplasticity, sauroine acetylation,  synaptic plasticity.","palabras_clave":"learning and memory|lycopodium alkaloids|sauroine acetylation|synaptic plasticity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38920,"idioma_id":4,"titulo":"Comparisons between conventional, ultrasound-assisted and microwave-assisted methods for extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae)","resumen":"This work reports a comparative study about extraction methods used to obtain anthraquinones (AQs)from stems and leaves of Heterophyllae pustulata Hook (Rubiáceae). One of the conventional procedures used to extract these metabolites from a vegetable matrix is by successive Soxhlet extractions with solvents of increasing polarity: starting with hexane to eliminate chlorophylls and fatty components, following by benzene and finally ethyl acetate. However, this technique shows a low extraction yield of total AQs, and consumes large quantities of solvent and time. Ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) have been investigated as alternative methods to extract these compounds, using the same sequence of solvents. It was found that UAE increases the extraction yield of total AQs and reduces the time and amount of solvent used. Nevertheless, the combination UAE with benzene, plus MAE with ethyl acetate at a constant power of 900Wshowed the best results. A higher yield of total AQs was obtained in less time and using the same amount of solvent that UAE. The optimal conditions for this latter procedure were UAE with benzene at 50 C during 60 min, followed by MAE at 900W during 15 min using ethyl acetate as extraction solvent.","palabras_clave":"ANTHRAQUINONES|ULTRASOUND-ASSISTED EXTRACTION|MICROWAVE ASSISTED EXTRACTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38921,"idioma_id":4,"titulo":"Kinetics modeling of the acidolysis with immobilized Rhizomucor miehei lipases for production of structured lipids from sunflower oil","resumen":"Sunflower oil modification for production of semisolid fats was carried out via acidolysis using palmitic and stearic acids (P+St), hexane and a developed biocatalyst from Rhizomucor miehei lipases. Its kinetic behavior was studied by employing three mathematical models proposed in the literature. Furthermore, a new model was proposed to describe not only the variation of triacylglycerols (TAG), diacylglycerols (DAG), and free fatty acids groups but also the acyl migration reaction occurrence. The effect of the reaction temperature on the kinetic and equilibrium parameters, as well as TAG and reaction intermediates profiles was analyzed. Increasing reaction temperature generated major changes in the overall composition of acylglycerols and gave rise to the highest composition of P+St in the obtained structured lipids (58%, 70 h, 60 °C). P+St incorporation was successfully adjusted by an empirical model (Model I) and a lumped parameter model (Model II) for all the studied reaction times, while the model based on a Ping Pong Bi Bi mechanism (Model III) was only able to describe the kinetics behavior (through the variation of reactant saturated fatty acids concentration) until 24 h. Experimental data were fit satisfactorily by the proposed model (Model IV), showing that the increment in the disaturated TAG formation achieved by the increment in temperature was principally related to the favored DAG formation from triunsaturated TAG.","palabras_clave":"ENZYME BIOCATALYSIS|MODELING|LIPASE|KINETIC PARAMETERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38922,"idioma_id":4,"titulo":"Simultaneous Quantitation of FFA, MAG, DAG, and TAG in Enzymatically Modified Vegetable Oils and Fats","resumen":"A novel and easy-to-implement high temperature  gas chromatographic procedure for the simultaneous quantitation  of free fatty acids (FFA), monoacylglycerols (MAG),  diacylglycerols (DAG), and triacylglycerols (TAG) for products  arising from fats and oils modification processes has been  developed. The method involves silylation in the presence of  pyridine at room temperature, standard injection system, and  FID detection. Species were separated by carbon number and  degree of unsaturation; thus, a total of 53 individual compounds  could be quantified. An identification plot for unavailable  triacylglycerol standard species relating relative retention  time with the number of double bonds was built. Calibration  curves for the quantitation of by-products (FFA, MAG, and  DAG) and a calibration surface for TAG were constructed  using standard solutions. Multiple internal standards were  used, achieving good repeatability. The method was tested  over a wide range of fatty acid unsaturation level (0 to 3  double bonds) and chain length (C14 to C18). The results  achieved in real samples were in agreement with those obtained  by fatty acid methyl esters (FAME) analysis and HPLC-RI.  The method developed is a rapid and reliable technique to  quantify FFA, MAG, DAG, and TAG in substrates and products  of modification, ideal to monitor the degree of conversion  in fats and oils enzymatic esterification, among others.","palabras_clave":"OILS|TRIACYLGLYCEROLS|DIACYLGLYCEROLS|MONOACYLGLYCEROLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38923,"idioma_id":4,"titulo":"Endophytic fungi of grasses protect other plants from aphid herbivory","resumen":"Microbial plant symbionts are widely spread in nature changing the way their hosts interact with their environment. Neotyphodium fungal endophytes (Clavicipitaceae) are grass symbionts known by their production of alkaloids, toxic for herbivores. Here, we hypothesized that endophytes confer associational protection to non-host plants andchange emission of host volatile-compounds. In an outdoor mesocosm experiment, we examined aphid infestation on Trifolium repens plants, in response to Neotyphodium occultans presence in neighbouring Lolium multiflorum. Contrasting levels of Rhizobium were generatedin T. repens plants considering that symbiosis with N2-fixers would influence herbivore abundance. Aphid infestation increased responding to symbiotic status of T. repens plants, when surrounded by non-symbiotic L. multiflorum plants. Endophytes modified the volatile imprints of L. multiflorum plants measured by an electronic nose, suggesting apotential mechanism to benefit neighbours. This associational protection constitutes a new mutualism trait of grass-endophyte symbiosis, becoming a non-private benefit available to other community partners.","palabras_clave":"ENDOPHYTIC FUNGI|APHID HERBIVORY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38924,"idioma_id":4,"titulo":"ASSESSMENT OF GLOBAL AND INDIVIDUAL REPRODUCIBILITY OF PROJECTIVE MAPPING WITH CONSUMERS","resumen":"The popularity of projective mapping with consumers for sensory characterization has markedly increased in the last five years. To have confidence in this methodology it is necessary to ensure that a similar product profile would emerge if the test was repeated, also, deciding whether the study should be replicated or not is a key issue in test implementation. In this context, the aim of the present work was to evaluate global and individual reproducibility of projective mapping for sensory characterization with consumers and to evaluate the influence of the size of difference among samples. Six consumer studies were conducted using a test?retest paradigm. In each study, responses from the same group of consumers to the same sample set in two different sessions were compared. Across the six studies individual reproducibility tended to be low. However, the RV coefficients of consensus sample configurations between sessions were higher than 0.75, suggesting that test-retest reproducibility of projective mapping with consumers proved to be relatively high.","palabras_clave":"sensory characterization| napping|Ultraflash profiling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38925,"idioma_id":4,"titulo":"Terpenoids from Azorella crypthanta","resumen":"One diterpenoidwith the azorellane carbon skeleton termed azorelaldehydeand two sesquiterpenoids with the guaiane carbon skeleton termed guai-1(10)-ene-&#61489;&#61489;&#61485;ol and 1&#61537;,5&#61538;-guaiane-4&#61538;&#61484;5&#61538;&#61484;&#61489;&#61489;&#61485;triol, were isolated fromtheAzorella cryptantha and characterized by 1D and 2D NMR spectroscopy.","palabras_clave":"AZORELLA CRYPTANTHA|APIACEAE|AZORELALDEHYDE|GUAI-1(10)-ENE-11-OL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38926,"idioma_id":4,"titulo":"On the Behaviour of General-Purpose Applications on Cloud Storages","resumen":"Managing data over cloud infrastructures raises novel chal- lenges with respect to existing and well studied approaches such as ACID and long running transactions. One of the main requirements is to pro- vide availability and partition tolerance in a scenario with replicas and distributed control. This comes at the price of a weaker consistency, usu- ally called eventual consistency. These weak memory models have proved to be suitable in a number of scenarios, such as the analysis of large data with Map-Reduce. However, due to the widespread availability of cloud infrastructures, weak storages are used not only by specialised appli- cations but also by general purpose applications. We provide a formal approach, based on process calculi, to reason about the behaviour of programs that rely on cloud stores. For instance, one can check that the composition of a process with a cloud store ensures ?strong? properties through a wise usage of asynchronous message-passing.","palabras_clave":"Cloud storage|Weak consistency"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38927,"idioma_id":4,"titulo":"Pholiota oblita (Strophariaceae, Agaricomycetes), a new species from the argentinean Yungas","resumen":"We present a study on the genus Pholiota sect.&nbsp; Adiposae&nbsp; stirps&nbsp; Subflammans from the Republic of Argentina.&nbsp; Pholiota&nbsp; oblita is proposed as a new species. It is characterized by its narrow lamellae, elongated cheilocystidia and broad spores. Singer originally described this species as P. digilioi, but this name was never validly published.&nbsp; Pholiota oblita is close to P. flammans, from the Northern Hemisphere, and&nbsp; P. subflammans, from the South American Andino-Patagonic forest, but differs by the diagnostic characters previously mentioned .&nbsp; The species&nbsp;&nbsp; was found in the southern end of the Yungas Forest, a cloud forest located on the eastern slopes of the sub-Andean mountains. Numerous collections of&nbsp; P. oblita&nbsp; were found in the Yungas forest but not in other areas. We believe that it could be an endemic species. Furthermore, we found&nbsp; that there are no herbarium specimens for the type of&nbsp; Pholiota subflammans (Speg.) Sacc. With the absence of original&nbsp; material, and to preserve current usage of the name, a neotype is designated hereby. The neotype chosen for P.&nbsp; subflammans&nbsp; is a specimen determined, described, and collected by Singer in the same area where the type specimen was found by Spegazzini.","palabras_clave":"AGARICALES|PHOLIOTA OBLITA|NEOTYPE|P.DIGILIOI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38928,"idioma_id":5,"titulo":"Leyendo a Mariátegui: las claves de José Aricó","resumen":"La  obra  del  pensador  peruano  José  Carlos  Mariátegui  constituye  un  importante hito  en  la  historia  de  las  ideas  en  América  Latina.  Desde  su  muerte  en  1930  hasta  la actualidad  ha  habido  múltiples  lecturas  de  sus  textos,  uno  de  los  puntos  más  discutidos  ha sido su adscripción a las filas del marxismo. A fines de los ?70, el intelectual argentino JoséAricó  reivindicó  al  peruano  como  una  de las  figuras  más  importantes  del  marxismolatinoamericano,  compilando  un  libro  que  tituló 'Mariátegui  y  los  orígenes  del  marxismo  latinoamericano'.En el presente artículo, nos valdremos de algunas herramientas teóricas de la Historia de las Ideas para mostrar la particular lectura que Aricó realiza de Mariátegui, centrándonos  en  una  de  las  obras  más  importantes  del  pensador  peruano,  los 'Siete  ensayos de interpretación de la realidad peruana'. ","palabras_clave":"Mariátegui  |Aricó|Historia de las Ideas|heterodoxia marxista"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38929,"idioma_id":4,"titulo":"Improvement of health risk factors after reduction of VOC concentrations in industrial and urban areas","resumen":"After reductions of fugitive and diffuse emissions  by an industrial complex, a follow-up study was performed to  determine the time variability of volatile organic compounds  (VOCs) and the lifetime cancer risk (LCR). Passive  samplers (3 M monitors) were placed outdoors (n=179) and  indoors (n=75) in industrial, urban, and control areas for  4 weeks. Twenty-five compounds including n-alkanes,  cycloalkanes, aromatics, chlorinated hydrocarbons, and  terpenes were determined by GC\/MS. The results show a  significant decrease of all VOCs, especially in the industrial  area and to a lesser extent in the urban area. The median  outdoor concentration of benzene in the industrial area declined  compared to the former study, around 85 % and about  50 % in the urban area, which in the past was strongly  influenced by industrial emissions. Other carcinogenic compounds  like styrene and tetrachloroethylene were reduced to  approximately 60 %. VOC concentrations in control areas  remained nearly unchanged. According to the determined  BTEX ratios and interspecies correlations, in contrast to the  previous study, traffic was identified as the main emission  source in the urban and control areas and showed an increased  influence in the industrial area. The LCR, calculated for  benzene, styrene, and tetrachloroethylene, shows a decrease  of one order of magnitude in accordance to the decreased total  VOC concentrations and is now acceptable according to  values proposed by the World Health Organization.","palabras_clave":"VOCs|Pollution index|health risk"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38930,"idioma_id":5,"titulo":"Los Polimorfismos en los genes GSTP1, GSTM1 y GSTT1 están asociados con el  riesgo de sufrir recaídas en los pacientes pediátricos con Leucemia Linfoblástica Aguda","resumen":"Abstract&nbsp;Theprediction of disease progression is one of the biggest challenges in oncology.The aim of this study was to find polymorphisms that help to iden­tify patientsdiagnosed with Acute Leukemia (AL) who are at high risk of relapse. We recruited 194patients with ALfrom Hospital Posadas. The pro­tocol was approved by the Ethic Committee andall patients, or guardians, signed an informed consent. Germline DNA wasisolated from peripheral blood lymphocytes and 5 polymorphisms were geno­typed:Glutathion-S-Transferases (GSTP1 c.313A&gt;G (p.Ile105Val); GSTM1 null; GSTT1 null),Multiple Drug Resistance gene 1 (ABCB1\/MDR1 c.3435T&gt;C), andMethylenetetrahydrofolate Reductase (MTHFR c.665C&gt;T). Twopolymorphisms (GSTM1 y GSTT1) were analyzed by multiplex PCR andthe other three by PCR-RFLP. We found that the GSTs combined genotype issignificantly associated with relapse (p=0.003). When we analyzed only thepediatric pa­tients (n=158) using a multivariate model, we found that the GSTP1 c.313GGgenotype increases the risk of relapse (HR=5.4; 95%CI=1.7-17.2; p=0.005). Wefurther restricted the analysis to pediatric patients with Acute LymphoblasticLeukemia with com­plete remission (n=136) and found a similar result (HR=5.6;95%CI=1.8-17.9; p=0.004). These results show that the genotype of the GSTsmight modify the ALprogression. The validation of these findings will help to choose a bettertreatment and follow-up schema for each patient diagnosed with AL accord­ing to theirgenotype.","palabras_clave":"LEUCEMIA AGUDA|RIESGO|RECAÍDA|GENOTIPO|POLIMORFISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38931,"idioma_id":4,"titulo":"Exploring jet-launching conditions for supergiant fast X-ray transients","resumen":"Context. In the magneto-centrifugal mechanism for jet formation, accreting neutron stars are assumed to produce relativistic jets only if their surface magnetic field is weak enough (B ~ 10^8 G). However, the most common manifestation of neutron stars are pulsars, whose magnetic field distribution peaks at B ~ 10^12 G. If the neutron star magnetic field has at least this strength at birth, it must decay considerably before jets can be launched in binary systems.  Aims. We study the magnetic field evolution of a neutron star that accretes matter from the wind of a high-mass stellar companion so that we can constrain the accretion rate and the impurities in the crust, which are necessary conditions for jet formation.  Methods. We solved the induction equation for the diffusion and convection of the neutron star magnetic field confined to the crust, assuming spherical accretion in a simpliflied one-dimensional treatment. We incorporated state-of-the-art microphysics, including consistent thermal evolution profiles, and assumed two different neutron star cooling scenarios based on the superfluidity conditions at the core.  Results. We find that in this scenario, magnetic field decay at long timescales is governed mainly by the accretion rate, while the impurity content and thermal evolution of the neutron star play a secondary role. For accretion rates &#7744; &#8819; 10^{-10} M&#8857; yr-1, surface magnetic fields can decay up to four orders of magnitude in ~10^7 yr, which is the timescale imposed by the evolution of the high-mass stellar companion in these systems. Based on these results, we discuss the possibility of transient jet-launching in strong wind-accreting high-mass binary systems like supergiant fast X-ray transients.","palabras_clave":"stars: neutron|magnetic fields|accretion, accretion disks|X-rays: binaries"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38932,"idioma_id":7,"titulo":"Bioactivity of microencapsulated essentials oils and perspectives of their use in the control of Varroa destructor","resumen":"Attractant\/repellent and acaricidal effects of two microencapsulated essential oils, Acantholippia seriphioides (A. Gray) Mold. and Schinus molle L., were evaluated on the ectoparasitic mite Varroa destructor Anderson et Truemann using complete exposure and evaporation tests. Mites and honey bees (10 specimens of each per dish) were introduced in Petri dishes having different microencapsulated essential oil doses (0.25, 0.5 and 1 g). Mite and honey bee mortality were registered at 24, 48 and 72 hrs. An attractant\/repellent test was performed using a device with two tubes of virgin wax closed on one side. Microencapsulated essential oils were placed at the end of one of the tubes. One mite was placed inside a tube with no oil and its position was observed after 90 min. Microencapsulated oils differed in the level of toxicity caused to V. destructor, A.seriphioides oil toxicity was higher than S. molle oil. Negative effects were registered on honey bees when they were completely exposed to microencapsulated oil of A. seriphioides. Microencapsulated oil of S. molle had attractant properties. None of the two microencapsulated oils tested had repellent effects on mites. This study might be a starting point for future researches of microencapsulated essential oils, as they offer a good alternative in the control of varroatosis.","palabras_clave":"Microencapsulated essential oils |Acantholippia seriphioides|Schinus molle|Varroa destructor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38933,"idioma_id":4,"titulo":"Sublethal effect of pyriproxyfen released from a fumigant formulation on fecundity, fertility and ovicidal action in Aedes aegypti (Diptera: Culicidae)","resumen":"Dengue and dengue hemorrhagic fever are mosquito-borne viral diseases that coincide  with the distribution of Aedes aegypti (L.), the primary vector in the tropical and semitropical world.  With no available vaccine, controlling the dengue vector is essential to prevent epidemics. The effects  of the insect growth regulator pyriproxyfen on Ae. aegypti adults that survived a treatment with a  sublethal dose were investigated in the laboratory, including effects on their reproductive potential.  Pyriproxyfen was released from a fumigant formulation at a dose causing 20 or 40% emergence  inhibition (%EI). Females were dissected before and after blood feeding and the basal follicle number  was counted. There were no differences between the control and treated group on the basal follicle  number for both doses used. Fertility and fecundity were reduced at a concentration of EI40 but no  at EI20. There was no ovicidal effect of pyriproxyfen by immersion of eggs in treated water neither  when the females laid their eggs on a pyriproxyfen-treated surface. This work shows that sublethal  doses of pyriproxyfen can have effects on fertility and fecundity ofAe. aegypti females, which together  with its larvicidal activity could contribute to an overall decrease in a given population.","palabras_clave":"Aedes aegypti|pyriproxyfen|fecundity| fertility|ovicidal action"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38934,"idioma_id":4,"titulo":"New age constraints for the Salamanca Formation and lower Río Chico Group in the western San Jorge Basin, Patagonia, Argentina: Implications for K\/Pg extinction recovery and land mammal age correlations","resumen":"The Salamanca Formation of the San Jorge Basin (Patagonia, Argentina) preserves critical records of Southern Hemisphere Paleo cene biotas, but its age remains poorly resolved, with estimates ranging from Late Cretaceous to middle Paleocene. We report a multi-disciplinary geochronologic study of the Salamanca Formation and overlying Río Chico Group in the western part of the basin. New constraints include (1) an 40Ar\/39Ar age determination of 67.31 ± 0.55 Ma from a basalt fl ow underlying the Salamanca Formation, (2) micropaleontological results indicating an early Danian age for the base of the Salamanca Formation, (3) laser ablation HR-MC-ICP-MS (high resolutionmulti collector-inductively coupled plasmamass spectrometry) U-Pb ages and a high resolution TIMS (thermal ionization mass spectrometry) age of 61.984 ± 0.041(0.074)[0.100] Ma for zircons from volcanic ash beds in the Peñas Coloradas Formation (Río Chico Group), and (4) paleomagnetic results  indicating that the Salamanca Formation in this area is entirely of normal polarity, with reversals occurring in the Río Chico Group.  Placing these new age constraints in the context of a sequence stratigraphic model for the basin, we correlate the Salamanca Formation  in the study area to Chrons C29n and C28n, with the Banco Negro Inferior (BNI), a mature widespread fossiliferous paleosol unit at the top of the Salamanca Formation, corresponding to the top of Chron C28n. The diverse paleobotanical assemblages from this area are here assigned to C28n (64.67?63.49 Ma), ~2?3 million years older than previously thought, adding to growing evidence for rapid Southern Hemisphere floral recovery after the Cretaceous-Paleogene extinction. Important Peligran and ?Carodnia? zone vertebrate fossil assemblages from coastal BNI and Peñas Coloradas exposures are likely older than previously thought and  correlate to the early Torrejonian and early Tiffanian North American Land Mammal Ages, respectively.","palabras_clave":"Paleogene|Patagonia|Age"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38935,"idioma_id":4,"titulo":"Fossil Araceae from the Late Cretaceous of Patagonia, Argentina with implications on the origin of free-floating aquatic aroids.","resumen":".....","palabras_clave":"Araceae|Fossil|Cretaceous|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38936,"idioma_id":4,"titulo":"Effect of Vrn-1, Ppd-1 genes and earliness per se on heading time in Argentinean bread wheat cultivars","resumen":"Predicting phenology, in particular heading time, is crucial to avoid and\/or minimize risk of damage of frost, drought and high temperatures during grain filling. Although some of the major genes controlling development, associated with photoperiod and vernalization responses, were identified, the association between the molecular characterization of those genes and photoperiod sensitivity, vernalization responses and earliness per se has been poorly studied. The present study was conducted to determine the effects of photoperiod and vernalization genes (and their allelic combination characterized by molecular approach) on heading time and its correlation with the phenological parameters determined by field experiments in a wide range of Argentine bread wheat commercial cultivars. Additionally, the association between photoperiod and vernalization responses with earliness per se was analyzed. Molecular characterization showed that most of the commercial Argentine wheat cultivars available in the market correspond to spring growth habit with dominant insensitive photoperiod alleles (SI) followed by spring habit sensitive to photoperiod (SS), while winter insensitive (WI) habit represented a minority group. All genotypes included in the present study (even those classified as SI and WI) were photoperiod sensitive when that trait was quantified from a physiological analysis as the slope of the relationship between duration of a particular phase and mean photoperiod sensed during the period between emergence and heading. SI showed lower photoperiod sensitivity than SS and WI, without clear differences between both later groups. In all cases, photoperiod sensitivity was the main attribute that determined the differences in time to heading even when vernalization requirements were not completely fulfilled in the WI. The genotypes with different photoperiod and vernalization allele combinations showed a wide range of duration of earliness per se. However, differences in earliness per se did not show any particular association with the groups classified by molecular markers for photoperiod and vernalization. The information included in the present study can be used to build a gene-based model for predicting phenology. However, the variations in photoperiod and\/or vernalization sensitivity within the same allelic combination could still determine mismatching in the prediction of the models based on Ppd-1 and Vrn-1 genes. © 2014 Elsevier B.V.","palabras_clave":"PHENOLOGY|PHOTOPERIOD|VERNALIZATION|WHEAT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38937,"idioma_id":4,"titulo":"Effects of acute and chronic exposure to predatory cues on spatial learning capabilities in the subterranean rodent Ctenomys talarum (Rodentia: Ctenomyidae)","resumen":"Spatial learning, the cognitive ability that allows animals to efficientlylocate food, partners or avoid predators, can be affected by various factorssuch as stress. Stressors represent a threat to the animal?s homeostasis andtrigger a set of physiological and behavioral changes known as stressresponse. The herbivorous rodent Ctenomys talarum (tuco-tuco) inhabitsunderground complex gallery systems. Dispersal as well as food collectionoccurs on the surface, where they are exposed to terrestrial and aerial predators.We evaluated the effect of a natural stress factor, predation, on spatiallearning of C. talarum. Additionally, we collected data on neutrophil\/lymphocyte ratio, hematocrit, blood glucose, and plasma cortisol to assessphysiological levels of stress. The acute exposure to direct cues indicatingthe presence of a predator (immobilization + cat urine) increased the timeneeded to reach the goal in a longitudinal labyrinth. The number of errorsalso increased albeit the difference was only marginally significant. Thechronic exposure to predator cues (immobilization, cat urine, and cat fur)presented in an unpredictable order significantly increased both time anderrors committed by tuco-tucos during learning trials in the labyrinth.Results show the strong impact of predatory stress on the spatial abilitiesof C. talarum, a key cognitive process involved in most of their vital activities.They also highlight the importance of investigating wild species asregards the development of antipredatory defensive behaviors that contributeboth to the avoidance of deleterious consequences of a direct attackand the influence on food search and mate localization performance.","palabras_clave":"APRENDIZAJE|ESTRES |PREDACION|CTENOMYS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38938,"idioma_id":4,"titulo":"Lectotypification, synonymy, and a new name in Senna series Aphyllae (Leguminosae: Caesalpinioideae)","resumen":"In series Aphyllae, Senna acanthoclada is lectotypified based on images housed at Albrecht von Haller Institute of Plant Sciences, Universität Göttingen; a new circumscription and synonyms for S. aphylla are given, and a new name: S. aphylla var. pendula var. nov. is proposed.","palabras_clave":"Senna|Aphyllae|nomenclature |Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38939,"idioma_id":4,"titulo":"Biodiesel production from Jatropha curcas: Integrated process optimization","resumen":"  Energy obtained from renewable sources has increased its participation in the energy matrix worldwide, and it is expected to maintain this tendency. Both in large and small scales, there have been numerous developments and research with the aim of generating fuels and energy using different raw materials such as alternative crops, algae and lignocellulosic residues. In this work, Jatropha curcas plantation from the North West of Argentina was studied, with the objective of developing integrated processes for low and medium sizes farms. In these cases, glycerine purification and meal detoxification processes represent a very high cost, and usually are not included in the project. Consequently, alternative uses for these products are proposed. This study includes the evaluation of the Jatropha curcas crop during two years, evaluating the yields and oil properties. The solids left after the oil extraction were evaluated as solid fuels, the glycerine and the meal were used to generate biogas, and the oil was used to produce biodiesel. The oil pretreatment was carried out with the glycerine obtained in the biodiesel production process, thus neutralizing the free fatty acid, and decreasing the phosphorous and water content.Jatropha curcas plantation from the North West of Argentina was studied, with the objective of developing integrated processes for low and medium sizes farms. In these cases, glycerine purification and meal detoxification processes represent a very high cost, and usually are not included in the project. Consequently, alternative uses for these products are proposed. This study includes the evaluation of the Jatropha curcas crop during two years, evaluating the yields and oil properties. The solids left after the oil extraction were evaluated as solid fuels, the glycerine and the meal were used to generate biogas, and the oil was used to produce biodiesel. The oil pretreatment was carried out with the glycerine obtained in the biodiesel production process, thus neutralizing the free fatty acid, and decreasing the phosphorous and water content.","palabras_clave":"Jatropha  |Biodiesel|Biogas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38940,"idioma_id":4,"titulo":"Frugivory and seed dispersal role of the Yellow-striped Brush-Finch (Atlapetes citrinellus), an endemic emberizid of Argentina","resumen":"The stability and dynamic of multispecies interactions often rely on a core of few species. We evaluate if the Yellow-striped Brush-Finch (Atlapetes citrinellus), the only endemic bird species from the Argentinean Yungas, is a core species for seed dispersal. Of 30 fleshy fruit species consumed, 16 were dispersed through endozoochory. The Yellow-striped Brush-Finch mostly used the 'cut or mash' fruit handling method. With this method, relatively large seeds (> 0.04 g) were equally discarded and swallowed. Medium- and small-sized seeds were more frequently swallowed than discarded. Although fruit species consumed were mostly from the understory, fruit consumption did not differ between forest understory and canopy when total fruit abundance by vertical stratum was considered. By using interaction network metrics, we determined that the seed dispersal role of Yellow-striped Brush-Finches during the rainy season was more important at higher altitudes and in the southern sector of its distributional range. Our findings support the idea that the Yellow-striped Brush-Finch must be considered a core seed disperser of understory and canopy fruits. Usage of network metrics is an effective way to assess the importance of individual species in a network, allowing restoration and conservation efforts to be focused on environments in which these species occur.","palabras_clave":"Atlapetes citrinellus|frugivory|mutualistic network metrics|Yungas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38941,"idioma_id":5,"titulo":"La teoría de la estratificación social de Parsons: una arquitectura del consenso y de la estabilización del conflicto","resumen":"INDIZADA EN: Latindex (Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal) Catálogo (certifica 34 características, incluido el par 20\/21, sistema de arbitraje y evaluadores externos); CLASE (Citas Latinoamericanas en Ciencias Sociales y Humanidades); RedALyC (Red de Revistas Científicas de América Latina y el Caribe). Considerada 'Revista Destacada' por los investigadores del CONICET (Encuesta de Revistas en Ciencias Sociales, CONICET-Centro Redes, www.centroredes.org.ar\/buscador).RESUMEN: En primer lugar, delimitamos los conceptos básicos de la teoría general de la acción que sirven de andamiaje a la teoría de la estratificación social de Talcott Parsons. En segundo lugar, identificamos los postulados esenciales de dicha teoría: la conformidad de la acción respecto de los valores colectivos como criterio decisivo de la diferenciación social, la clasificación de tipos de estratificación social en función de las normas de valor predominantes, la definición de una jerarquía individual de sanciones y recompensas, la proporcionalidad entre mérito y recompensa, entre otros. En tercer lugar, damos cuenta de la particular interpretación que elabora el autor respecto del sistema de estratificación de las sociedades modernas industrializadas y hacemos foco en su noción de status de clase y en la introducción del problema del poder a la hora de explicar las estratificaciones empíricas. En cuarto lugar, analizamos los argumentos parsonianos destinados a desdibujar la existencia de las clases y del conflicto en las sociedades industrializadas. Finalmente, exponemos nuestras conclusiones y relacionamos esta teoría de la estratificación con algunos principios básicos de la ideología liberal y neo-liberal dominante.","palabras_clave":"Parsons|estratificación social|consenso|status"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38942,"idioma_id":5,"titulo":"Proliferación subdisciplinar en biología, debacle del reduccionismo y nuevas estrategias de unificación","resumen":"Durante las últimas décadas, la biología ha sido objeto de una considerable proliferación teórica y subdisciplinar, hecho que suscita la pregunta acerca de su unidad. Por ello, a partir del abandono del reduccionismo como estrategia unificadora, el interrogante filosófico es qué otras formas alternativas de relaciones subdisciplinares son posibles, y si dichas relaciones logran dar unidad a la biología. En el presente trabajo, a partir de una primera consideración de algunos de los problemas que el reduccionismo ha tenido en biología, analizaremos diferentes tipos de relaciones subdisciplinares que se encuentran en la biología contemporánea. En particular, indagaremos cuatro de las principales propuestas que pueden encontrarse en la literatura filosófica especializada. A su vez, ofreceremos dos nuevas propuestas de relación: isomorfismo, presente en el área de la biología evolutiva, e importación\/exportación de cuerpos teóricos, propia de la relación entre ecología y fisiología. Finalmente, a partir del recorrido realizado, presentaremos algunas consideraciones en torno al objetivo de la unidad de la ciencia en general, como también acerca de la clase de cohesión que creemos posible para la biología a partir de nuestros análisis, defendiendo la idea de un pluralismo de las relaciones interdisciplinares y de la unidad como un fenómeno local.","palabras_clave":"UNIDAD DE LA BIOLOGÍA|REDUCCIONISMO|RELACIONES SUBDISCIPLINARES|IMPORTACIÓN DE MARCOS TEÓRICOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38943,"idioma_id":4,"titulo":"Nitric oxide is required for determining root architecture and lignin composition in sunflower. Supporting evidence from microarray analyses","resumen":"Nitric oxide (NO) is a signal molecule involved in several physiological processes in plants, including root development. Despite the importance of NO as a root growth regulator, the knowledge about the genes and metabolic pathways modulated by NO in this process is still limited. A constraint to unravel these pathways has been the use of exogenous applications of NO donors that may produce toxic effects. We have analyzed the role of NO in root architecture through the depletion of endogenous NO using the scavenger cPTIO. Sunflower seedlings growing in liquid medium supplemented with cPTIO showed unaltered primary root length while the number of lateral roots was deeply reduced; indicating that endogenous NO participates in determining root branching in sunflower. The transcriptional changes induced by NO depletion have been analyzed using a large-scale approach. A microarray analysis showed 330 genes regulated in the roots (p &#10877; 0.001) upon endogenous NO depletion. A general cPTIO-induced up-regulation of genes involved in the lignin biosynthetic pathway was observed. Even if no detectable changes in total lignin content could be detected, cell walls analyses revealed that the ratio G\/S lignin increased in roots treated with cPTIO. This means that endogenous NO may control lignin composition in planta. Our results suggest that a fine tuning regulation of NO levels could be used by plants to regulate root architecture and lignin composition. The functional implications of these findings are discussed.","palabras_clave":"CPTIO|LIGNIN|MICROARRAY|NITRIC OXIDE|PHENYLPROPANOID BIOSYNTHESIS|ROOT ARCHITECTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38944,"idioma_id":4,"titulo":"DIFFUSE REFLECTANCE OPTICAL TOPOGRAPHY: LOCATION OF INCLUSIONS IN 3D AND DETECTABILITY LIMITS","resumen":"In the present contribution we investigate the images of CW diffusely reflected light for a point-like source, registered by a CCD camera imaging a turbid medium containing an absorbing lesion. We show that detection of&nbsp; variations in the absorption coefficient(absorption anomalies) is achieved if images are normalized tobackground intensity. A theoretical analysis based on the diffusionapproximation is presented to investigate the sensitivity and thelimitations of our proposal and a novel procedure to find the location ofthe inclusions in 3D is given and tested. An analysis of the noise and itsinfluence on the detection capabilities of our proposal is provided.Experimental results on phantoms are also given, supporting the proposedapproach.","palabras_clave":"TURBID MEDIA|BIOMEDICAL OPTICS|IMAGING OF BIOLOGICAL TISSUE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38946,"idioma_id":4,"titulo":"Transtensional tectonics induced by oblique reactivation of previous lithospheric anisotropies during the Late Triassic to Early Jurassic rifting in the Neuquén basin: insights from analog models","resumen":"The goal of this study was to determine the main factors that controlled the kinematic evolution and the structural architecture developed during the Late Triassic to Early Jurassic rifting that led to the opening of the Neuquén basin in the southwestern sector of Gondwana. We carried out a series of analog models to simulate an extensional system with a bent geometry similar to the northeastern border of the basin. In different experiments, we varied the extension direction between NNE (N10°E) and NE (N45°E) orientations, inducing rift systems with different degrees of obliquity in each sector of the extended area. We compared the kinematic evolution and the final structural architecture observed in the experiments with data from two selected representative areas of the basin: (1) the Atuel depocenter, situated in the northern Andean sector, and (2) the Entre Lomas area, situated in the northeastern Neuquén Embayment. In both cases, the good match between the field and subsurface data and the results of the analog models supports a NNE orientation of the regional extension (N30°E - N20°E) during the synrift stage. Our experimental results suggest that lithospheric weakness zones of NNW to NW trend could have controlled and localized the extension in the Neuquén basin. These previous anisotropies were linked to the sutures and rheological contrasts generated during the collision of terranes against the southwestern margin of Gondwana during the Paleozoic, as well as further modifications of the thermo-mechanical state of the lithosphere during the Late Paleozoic to Early Mesozoic evolution.","palabras_clave":"Western Gondwana|Neuquén basin|Central Andes|Oblique rifting|Structural inheritance|Analog modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38947,"idioma_id":4,"titulo":"A tabu search heuristic for the Equitable Coloring Problem","resumen":"The Equitable Coloring Problem is a variant of the Graph  Coloring Problem, where the sizes of two arbitrary color classes differ  in at most one unit. This paper describes a new tabu search heuristic  for the Equitable Coloring Problem. This algorithm is an adaptation  of the dynamic TabuCol version of Galinier and Hao. Computational  experiments are carried out in order to find the best combination of  parameters involved in the tabu search heuristic, and to show its good  performance over benchmark instances","palabras_clave":"EQUITABLE COLORING|TABU SEARCH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38948,"idioma_id":4,"titulo":"Chronic Alcohol Consumption Alters Periodontal Health in Rats","resumen":"Background: The aim of the present study was to assess the effects of chronic alcohol consumption on periodontitis development in rats. Methods: Periodontal disease was experimentally induced by lipopolysaccharide (LPS, 2 mg\/ml) injections into the gingival tissue around &#64257;rst upper and lower molar?s neck, and into the inter-dental space between &#64257;rst and second molars. This protocol was repeated for 6 weeks on days 1, 3, and 5 of each week. Chronic alcohol consumption was induced by 20% ethanol as the only liquid source during 4 months. Results: Chronic alcohol consumption by itself increased alveolar bone loss and biological mediators of periodontal disease such as prostaglandin E2 (PGE2) content on gingival tissue, and inducible nitric oxide synthase activity (iNOS) plus PGE2 content in submandibular gland (SMG). Unexpectedly, alcohol consumption did not increase the damage evoked by the proved model of LPS injections for periodontitis induction. Conclusion: Results suggest 20% alcohol consumption during 4 months generates differential effects on oral health of rats, depending on its pathophysiological state: it would exacerbate the inflammatory condition when periodontal damage is absent, but it would not when damage is installed.","palabras_clave":"ALCOHOL CONSUMPTION|PERIODONTAL DAMAGE|ALVEOLAR BONE LOSS|INFLAMMATORY MARKERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38949,"idioma_id":4,"titulo":"Context of action of Proline Dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis","resumen":"Background: Proline (Pro) dehydrogenase (ProDH) potentiates the oxidative burst and cell death of the plant  Hypersensitive Response (HR) by mechanisms not yet elucidated. ProDH converts Pro into delta 1 pyrroline-5-carboxylate  (P5C) and can act together with P5C dehydrogenase (P5CDH) to produce Glu, or with P5C reductase (P5CR) to  regenerate Pro and thus stimulate the Pro\/P5C cycle. To better understand the effects of ProDH in HR, we studied  the enzyme at three stages of the defense response differing in their ROS and cell death levels. In addition, we  tested if ProDH requires P5CDH to potentiate HR.  Results: Control and infected leaves of wild type and p5cdh plants were used to monitor ProDH activity, in vivo  Pro catabolism, amino acid content, and gene expression. Wild type plants activated ProDH at all HR stages. They  did not consume Pro during maximal ROS accumulation, and maintained almost basal P5C levels at all conditions.  p5cdh mutants activated ProDH as wild type plants. They achieved maximum oxidative burst and cell death levels  producing normal HR lesions, but evidenced premature defense activation.  Conclusion: ProDH activation has different effects on HR. Before the oxidative burst it leads to Pro consumption  involving the action of P5CDH. During the oxidative burst, ProDH becomes functionally uncoupled to P5CDH and  apparently works with P5CR. The absence of P5CDH does not reduce ROS, cell death, or pathogen resistance, indicating  this enzyme is not accompanying ProDH in the potentiation of these defense responses. In contrast, p5cdh infected  plants displayed increased ROS burst and earlier initiation of HR cell death. In turn, our results suggest that ProDH may  sustain HR by participating in the Pro\/P5C cycle, whose action on HR must be formally evaluated in a future.","palabras_clave":"PROLINE METABOLISM|PROLINE DEHYDROGENASE|ARABIDOPSIS|HYPERSENSITIVE RESPONSE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38950,"idioma_id":4,"titulo":"L-Phenylalanine Transport in Saccharomyces cerevisiae: Participation of GAP1, BAP2, and AGP1","resumen":"We focused on the participation of GAP1, BAP2, andAGP1 in L-phenylalanine transport in yeast. In order to study the physiological functions of GAP1, BAP2, and AGP1 in L-phenylalanine transport, we examined the kinetics, substrate specificity, and regulation of these systems, employing isogenic haploid strains with the respective genes disrupted individually and in combination. During thecharacterization of phenylalanine transport, we noted important regulatory phenomena associated with these systems. Our results show that Agp1p is the major transporter of the phenylalanine in a gap1 strain growing in synthetic media with leucine present as an inducer. In a wild type strai","palabras_clave":"Phenylalanine Transport|Saccharomyces cerevisiae|permeases"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38951,"idioma_id":4,"titulo":"Enhancement of the optical response in a biodegradable polymer\/azo-dye film by the addition of carbon nanotubes","resumen":"A new biodegradable photoresponsive material was developed using poly(lactic acid) (PLA) asthe matrix material and Disperse Orange 3 (DO3) as photoisomerizable azo-dye. It wasobserved that the addition of multi-walled carbon nanotubes (MWCNTs) leads to a newphenomenon consisting of an enhancement of the optical anisotropy in a wide range oftemperatures. In particular, the optical anisotropy increases 100% at room temperature.Moreover, the material containing MWCNTs shows a faster optical response that is evidencedas an increase in the growth rate of optical anisotropy. Spectroscopic data is provided to studythe interaction among DO3, MWCNTs and PLA. The enhancement of optical anisotropyobtained with the addition of MWCNTs was related to the glass transition temperature (Tg) ofeach material. Maximum optical anisotropy was obtained 15&#9702;C below the Tg for bothmaterials. Results are interpreted in terms of the interactions among DO3, MWCNTs and PLAand the packing density of the dye into the polymer chains.","palabras_clave":"optical properties|photosensitive materilas|biodegradable material azo-dye"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38952,"idioma_id":4,"titulo":"The magnetic field in HD 161701, the only binary system identified to consist of an HgMn primary and an Ap secondary","resumen":"Recently, we performed a complete study of the SB2 system HD 161701 with  an orbital period of 12.5 d, consisting of an HgMn primary and a  classical Ap secondary. Since this is the first system identified with  this particular combination of peculiar stars, a study of the presence  of a magnetic field in both components is of considerable interest to  astronomers studying stellar magnetism and the impact of the presence of  a magnetic field in binary systems. Apart from HD 161701, only one other  close binary systems with a magnetic Ap component, the system HD 98088,  is currently known. Using high accuracy radial velocity planet searcher  (HARPS) polarimetric spectra obtained on six consecutive nights, we  detect in the Ap component a mean longitudinal magnetic field of up to  200 G varying in strength over the orbital\/rotational period. The  magnetic field behaviour in this component is closely related to the  position of the primary component, exhibiting negative polarity. There  was no detection of any longitudinal magnetic field with an upper limit  of ?90 G in the primary. L81","palabras_clave":"stars: abundances|stars: atmospheres|stars: binaries: spectroscopic|stars: chemically peculiar|stars: magnetic field"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38953,"idioma_id":5,"titulo":"DESARROLLO DE UN SISTEMA PREDICTIVO DE POTENCIA FV PARA SU UTILIZACIÓN EN SISTEMAS HIBRIDOS","resumen":"RESUMEN","palabras_clave":"IRRADIANCIA|TEMPERATURA CELDA|LOGICA DIFUSA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38954,"idioma_id":4,"titulo":"New objects with the B[e] phenomenon in the Large Magellanic Cloud","resumen":"Aims. The study is aimed at discovering new objects with the B[e] phenomenon in the Large Magellanic Cloud. Methods. We report medium-resolution optical spectroscopic observations of two newly found (ARDB 54 and NOMAD 0181-0125572) and two previously known (Hen S-59 and Hen S-137) supergiants with the B[e] phenomenon in the Large Magellanic Cloud. The observations were obtained with the GMOS spectrograph at the southern Gemini telescope. Results. Optical spectra of ARDB 54 and NOMAD 0181-0125572 are presented for the first time as well as their fundamental parameters. We found that the Balmer line profiles of Hen S-59 and Hen S-137 were different from those observed in their spectra nearly 20 years ago. We suggest a higher effective temperature and luminosity for both objects. With the new fundamental parameters, the lowest luminosity for known supergiants with the B[e] phenomenon in the Magellanic Clouds is higher that previously thought (log L\/Lo = 4.5 instead of 4.0). Hen S-59 may be a binary system based on its UV excess, variable B - V colour-index and radial velocity of emission lines, and periodically variable I-band brightness.","palabras_clave":"STARS: EMISSION LINE|STARS: EARLY-TYPE, BE|STARS: SUPERGIANTS|STARS: CIRCUMSTELLAR MATTER|TECHNIQUE: SPECTROSCOPIC|GALAXIES: INDIVIDUAL: LARGE MAGELLANIC CLOUD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38956,"idioma_id":4,"titulo":"Source and trophic transfer of mercury in plankton from an ultraoligotrophic lacustrine system (Lake Nahuel Huapi, North Patagonia)","resumen":"                      The incorporation and trophic transfer of total and methyl mercury (THg, MeHg) were examined in three size classes of plankton (10-53, 53-200, and &gt;200 µm size range) and a small planktivorous fish, Galaxias maculatus, from the large multi-branched Lake Nahuel Huapi (North Patagonia, Argentina). Three sites representing a large range of lake benthic?pelagic structures (based on depth and shoreline characteristics) and precipitation regimes were sampled. Nitrogen and carbon stable isotopes (d15N, d13C)were analyzed to assess Hg trophodynamics. Selenium concentrations were determined together with THg in order to consider its potential effect on Hg trophodynamics. High THg concentrations (0.1-255 µg g-1 dry weight (DW)) were measured in plankton, largely in inorganic form (MeHg: 3-29 ng g-1 DW, 0.02-7 % of THg, in the two larger size classes). A trend of increasing THg concentrations, varying in two to three orders of magnitude, with decreasing plankton size was associated with precipitation measured prior to each sampling event. Passive adsorption of dissolved Hg2+ from wet deposition and runoff is considered to be the principal Hg uptake mechanism at the base of the pelagic food web. Despite the initially high THg uptake in the smaller plankton classes, the transfer to G. maculatus, and consequently to the entire food web, is likely limited due to low proportion of MeHg to THg in plankton. Furthermore, evidence of G. maculatus with benthic feeding habits having higher impact on MeHg trophic transfer compared to the same species with more pelagic (e.g., zooplankton) feeding habits, was observed. Although there is a high THg uptake in plankton, limited amounts are incorporated in the entire food web from the pelagic compartment.","palabras_clave":"MERCURY|SELENIUM|PLANKTON|LAKE FOOD WEB"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38957,"idioma_id":4,"titulo":"A Rhomboid Protease Gene Deletion Affects a Novel Oligosaccharide N-linked to the S-\tlayer Glycoprotein of Haloferax volcanii","resumen":"Rhomboid proteases occur in all domains of life, however, their physiological role is not completely understood and nothing is known on the biology of these enzymes in Archaea. One of the two rhomboid homologs of Haloferax volcanii (RhoII) is fused to a Zn-finger domain. Chromosomal deletion of rhoII was successful indicating that this gene is not essential for this organism; however, the mutant strain (MIG1) showed reduced motility and increased sensitivity to novobiocin. Membrane preparations of MIG1 were enriched in two glycoproteins, identified as the S-layer glycoprotein and an ABC transporter component. The H. volcanii S-layer glycoprotein has been extensively used as a model to study haloarchaeal protein N-glycosylation. HPLC analysis of oligosaccharides released from the S-layer glycoprotein after PNGase treatment revealed that MIG1 was enriched in species with lower retention times than those derived from the parent strain. Mass spectrometry analysis showed that the wild type glycoprotein released a novel oligosaccharide species corresponding to GlcNAc-GlcNAc(Hex)2-(SQ-Hex)6 in contrast to the mutant protein which contained the shorter form GlcNAc2(Hex)2-SQ-Hex-SQ. A glyco-proteomics approach of the wild type glycopeptide fraction revealed N732 peptide fragments linked to the sulfoquinovose-containing oligosaccharide. This work describes a novel N-linked oligosaccharide containing a repeating SQ-Hex unit bound to N732 of the H. volcanii S-layer glycoprotein, a position which had not been reported as glycosylated. Furthermore, this study provides the first insight on the biological role of rhomboid proteases in Archaea, suggesting a link between protein glycosylation and this protease family. ","palabras_clave":"Rhomboid protease|Archaea|Glycosylation|Glycoprotein|Mass spectrometry|Halophiles"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38958,"idioma_id":4,"titulo":"Nonlinear Dynamics of internet congestion control: A frequency domain approach","resumen":"In this paper a fluid-flow model for TCP congestion avoidance combined with different AQM schemes is analyzed. The conditions for the appearance of Hopf bifurcations are stated analytically using frequency-domain techniques. The proposed methodology allows the characterization of the emerging periodic orbits, providing approximations of their amplitude and frequency. In addition, multiple oscillations and limit cycle bifurcations are found via numerical tools","palabras_clave":"Time-delay systems|Frequency-domain approach|Internet congestion control|Multiple oscillations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38959,"idioma_id":4,"titulo":"Magnetic Properties of Weakly Exchange-Coupled High Spin Co(II) Ions in Pseudooctahedral Coordination Evaluated by Single Crystal X&#8209;Band EPR Spectroscopy and Magnetic Measurements","resumen":"We report single-crystal X-band EPR and magnetic measurements of the coordination polymer catena-(trans-(&#956;2-fumarato)tetraaquacobalt(II)), 1, and the Co(II)-doped Zn(II) analogue, 2, in different Zn:Co ratios. 1 presents two magnetically inequivalent high spin S = 3\/2 Co(II) ions per unit cell, named A and B, in a distorted octahedral environment coordinated to four water oxygen atoms and trans coordinated to two carboxylic oxygen atoms from the fumarate anions, in which the Co(II) ions are linked by hydrogen bonds and fumarate molecules. Magnetic susceptibility and magnetization measurements of 1 indicate weak antiferromagnetic exchange interactions between the S = 3\/2 spins of the Co(II) ions in the crystal lattice. Oriented single crystal EPR experiments of 1 and 2 were used to evaluate the molecular g-tensor and the different exchange coupling constants between the Co(II) ions, assuming an effective spin S&#8242;= 1\/2. Unexpectedly, the eigenvectors of the molecular g-tensor were not lying along any preferential bond direction, indicating that, in high spin Co(II) ions in roughly octahedral geometry with approximately axial EPR signals, the presence of molecular pseudo axes in the metal site does not determine preferential directions for the molecular g-tensor. The EPR experiment and magnetic measurements, together with a theoretical analysis relating the coupling constants obtained from both techniques, allowed us to evaluate selectively the exchange coupling constant associated with hydrogen bonds that connect magnetically inequivalent Co(II) ions (|JAB1\/2| = 0.055(2) cm?1) and the exchange coupling constant associated with a fumarate bridge connecting equivalent Co(II) ions (|JAA1\/2| &#8776; 0.25 (1) cm?1), in good agreement with the average J3\/2 value determined from magnetic measurements.","palabras_clave":"COBALT|EXCHANGE INTERACTION|SINGLE CRYSTAL EPR|ZERO FIELD SPLITTING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38960,"idioma_id":4,"titulo":"Mockup-Driven Development: Providing agile support for Model-Driven Web Engineering","resumen":"Agile software development approaches are currently becoming the industry standard for WebApplication development. On the other hand, Model-Driven Web Engineering (MDWE) methodologiesare known to improve productivity when building this kind of applications. However, current MDWEmethodologies tend to ignore important aspects of Web Applications development supported by agileprocesses, such as constant customer feedback or early design of user interfaces.Objective: In this paper we analyze the difficulties of supporting agile features in MDWE methodologies.Then, we propose an approach that eases the incorporation of well-known agile practices to MDWE.Method: We propose using User Interface prototypes (usually known as mockups) as a way to start themodeling process in the context of a mixed agile-MDWE process. To assist this process, we defined alightweight metamodel that allows modeling features over mockups, interacting with end-users and generatingMDWE models. Then, we conducted a statistical evaluation of both approaches (traditional vs.mockup-based modeling).Results: First we comment on how agile features can be added to MDWE processes using mockups. Then,we show by means of a quantitative study that the proposed approach is faster, less error-prone and stillas complete as traditional MDWE processes.Conclusion: The use of mockups to guide the MDWE process helps in the reduction of the developmentcycle as well as in the incorporation of agile practices in the model-driven workflow. Complete MDWEmodels can be built and generated by using lightweight modeling over User Interface mockups, and thisprocess suggests being more efficient, in terms of errors and effort, than traditional modeling in MDWE.","palabras_clave":"Mockups|User-Interface|Agile|Web Engineering|MDD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38961,"idioma_id":5,"titulo":"Populismo, instituciones locales y democracia (Provincia de Buenos Aires, 1945-1958)","resumen":"La imagen de un peronismo centralizador y autoritario, aún hoy hegemónica en las ciencias sociales, es en buena medida un legado de la autoproclamada revolución libertadora. Estas interpretaciones han sido construidas desde una perspectiva tocquevilliana, asociando a priori las ideas de descentralización, activación de la sociedad civil y democracia. En este artículo  retomaremos aquellas investigaciones que consideran a los populismos como fuerzas inclusivas y democratizantes, repensando las relaciones entre peronismo clásico e instituciones locales, una dimensión que ha sido poco analizada. En concreto, indagaremos en los cambios y continuidades que sufrieron los municipios y los Consejos Escolares de la provincia de Buenos Aires antes y después del peronismo.","palabras_clave":"populismo|democracia|municipio|consejos escolares"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38962,"idioma_id":4,"titulo":"Analytical methodology optimization to estimate the content of non-flavonoid phenolic compounds in Argentine propolis extracts","resumen":"Abstract  Context: Traditionally, the content of total phenolics (flavonoid phenolics (FP) and nonflavonoid phenolics (NFP)) and flavonoids (flavone\/flavonol and flavonone\/dihydroflavonol)  in propolis has been determined by different methodologies. Until now, the percentage oftot al phenolic (TP) compounds that corresponds to FP and NFP, expressed in the same units by a spectrophotometric method, has not been determined.  Objective: The current study proposes a quick and simple methodology that separates FP and NFP in propolis samples and determines TP, FP, and NFP by the same method.  Materials and methods: Propolis samples from five Argentine provinces (Tucuma ´n, Santiago del Estero, Salta, Misiones, and Jujuy) were used. Extraction of TP from the propolis samples was  carried out by maceration with 80% ethanol and quantified by Folin?Ciocalteu reagent (FC-R).  Then, FP was precipitated with formaldehyde in acid medium. After centrifugation, NFP were determined in the supernatant using FC-R. FP content was calculated as the difference between the content of TP and NFP. The method was also validated using commercial flavonoids and  chalcones.  Results: FP recovery in all experiments was between 85.95% and 98.29%. Propolis from Tucuma´n had significantly higher amounts of total phenols than propolis from other provinces.  SE5 showed higher content of FP (81.52%) followed by SA1 (74.75%). The propolis from TUC4,SA4, SE3, and MI showed the lowest FP content and highest content of NFP.  Conclusions: This method provides a simple, reliable, and specific spectrophotometric assay to estimate the content of NFP, FP, and TP in propolis samples.","palabras_clave":"propolis|flavonoid phenolic precipitation, |total phenolic compounds content|determination of phenolic non flavonoides"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38963,"idioma_id":4,"titulo":"ANTIMICROBIAL ACTIVITY OF ARGENTINEAN PROPOLIS AGAINST  Staphylococcus ISOLATED OF CANINE OTITIS","resumen":"ABSTRACT      Increasing resistance toward the available antibiotics by various microbial diseases pushed veterinarian to think about alternative therapies. Propolis is a natural compound well known since ancient times for its therapeutic effects and has been employed in traditional veterinary medicine. The aim of this study was to analyze the chemical composition of 12 propolis ethanolic extracts (PEEs) from different provinces of Northern Argentina and evaluate their antimicrobial activity against Staphylococcus strains isolated from canine otitis.  Thirteen compounds (eight flavonoids, two chalcones and three phenolic   acids) were identified by TLC, spectrophotometric methods and HPLC-DAD. PEEs were effective against Staphylococcus strains. The highest antibacterial activities were found in samples from Tucumán   province. All propolis samples were considered bacteriostatic and the selection of resistant phenotypes did not occur in presence of Argentinean-PEE. Results of the present study indicate that propolis   extracts might be an effective alternative against canine otitis-causing S. aureus strains in vivo.","palabras_clave":"ARGENTINIAN PROPOLIS |CHEMICAL COMPOSITION |ANTIMICROBIAL ACTIVITY|CANINE OTITIS|Staphylococcus STRAINS |VETERINARY USE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38964,"idioma_id":4,"titulo":"Insights from the zero-angular-momentum wave in single and double ionization of He by fast electrons","resumen":"In a recent contribution our group proposed a perturbative approach to deal with the open problem of double ionization of helium by electron impact. The goal of this work is to delve into the physics of the scattering function, and provide evidence of the nature of the single-ionization channels present in the three-body wave function. We show that the fast oscillating parts of the wave function are indeed the single-ionization channels, which appear coupled with the double continuum ones. We found a particular type of basis set within the Generalized Sturmian method that is better suited to isolate single from double-ionization channels.","palabras_clave":"ionization|sturmians"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38965,"idioma_id":4,"titulo":"Prolactin induces apoptosis of lactotropes in female rodents","resumen":"Abstract  Anterior pituitary cell turnover occurring during female sexual cycle is a poorly understood process that involves complex regulation of cell proliferation and apoptosis by multiple hormones. In rats, the prolactin (PRL) surge that occurs at proestrus coincides with the highest apoptotic rate. Since anterior pituitary cells express the prolactin receptor (PRLR), we aimed to address the actual role of PRL in the regulation of pituitary cell turnover in cycling females. We showed that acute hyperprolactinemia induced in ovariectomized rats using PRL injection or dopamine antagonist treatment rapidly increased apoptosis and decreased proliferation specifically of PRL producing cells (lactotropes), suggesting a direct regulation of these cell responses by PRL. To demonstrate that apoptosis naturally occurring at proestrus was regulated by transient elevation of endogenous PRL levels, we used PRLR-deficient female mice (PRLRKO) in which PRL signaling is totally abolished. According to our hypothesis, no increase in lactotrope apoptotic rate was observed at proestrus, which likely contributes to pituitary tumorigenesis observed in these animals. To decipher the molecular mechanisms underlying PRL effects, we explored the isoform-specific pattern of PRLR expression in cycling wild type females. This analysis revealed dramatic changes of long versus short PRLR ratio during the estrous cycle, which is particularly relevant since these isoforms exhibit distinct signaling properties. This pattern was markedly altered in a model of chronic PRLR signaling blockade involving transgenic mice expressing a pure PRLR antagonist (TG&#916;1-9-G129R-hPRL), providing evidence that PRL regulates the expression of its own receptor in an isoform-specific manner. Taken together, these results demonstrate that i) the PRL surge occurring during proestrus is a major proapoptotic signal for lactotropes, and ii) partial or total deficiencies in PRLR signaling in the anterior pituitary may result in pituitary hyperplasia and eventual prolactinoma development, as observed in TG&#916;1-9-G129R-hPRL and PRLRKO mice, respectively.","palabras_clave":"PROLACTIN|APOPTOSIS|ESTROUS CYCLE|ANTERIOR PITUITARY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38966,"idioma_id":4,"titulo":"Predator-prey imbalances due to a pesticide: density and applicability timing as determining factors for experimental assessments","resumen":"Predator-prey relationships are determining factors in sustaining community structure but xenobiotics, including pesticides, have the potential to alter them, causing imbalances at the ecosystem level. Although invertebrate predation on zooplankton is of high importance in shallow lakes, there is still little information regarding disturbances on this trophic interaction.  This work assessed the potential effects of a chlorpyrifos-based pesticide (CLP) on the interaction between prawns Macrobrachium borellii and cladocerans Ceriodaphnia dubia, taking into account prey densities, specific time of exposure and contamination level. The analysis was focused on the specific sensitivity of both species and, especially, on the predation rate of M. borellii on C. dubia. The latter was evaluated through different treatments that combined predator and\/or prey exposure to the insecticide, before (lapse of 12 h) or during the interaction.    Under low prey density, when prawns were previously exposed to the insecticide, their consumption rate was lower than that of controls. Conversely, when cladocerans or both species were previously exposed, the prawns? feeding rate was higher. Under high prey density, there were no substantial differences among treatments. Comparatively, cladocerans were significantly more consumed when the exposure of both species was performed before rather than during the interaction. From the results obtained, it can be assumed that the trophic interaction under study is sensitive to CLP and that individual density and specific time of exposure are important variables to be considered in similar studies in order to obtain realistic results.","palabras_clave":"CERIODAPHNIA DUBIA|MACROBRACHIUM BORELLII|AQUATIC ENVIRONMENTS|POLLUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38967,"idioma_id":4,"titulo":"A theoretical model of the diffusion process to spherical and isotropic fruits","resumen":"El artículo presenta un modelo teórico de la difusión de líquidos en frutos esféricos, a través de su superficie. Para su obtención se resolvió la ecuación diferencial de la difusión aplicada a la concentración en función del tiempo en todo punto de la pulpa del fruto.Para su solución se utilizaron como valores de las condiciones iniciales de contorno, las mediciones realizadas en laboratorio.","palabras_clave":"frutos esféricos|difusión|modelo teórico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38968,"idioma_id":4,"titulo":"In situ synchrotron radiation X-ray scattering study on the effect of a stearic sucrose ester on polymorphic behavior of a new sunflower oil variety","resumen":"The effect of the stearic sucrose ester (SE) S-170 on crystallization behavior and polymorphism of two stearins obtained from a new variety of high stearic high oleic sunflower oil was studied by pulsed nuclear magnetic resonance (p-NMR), small (SAXS) and wide (WAXS) angle X-ray scattering using synchrotron light and differential scanning calorimetry (DSC). p-NMR studies showed that there is always a crystallization temperature below which SE S-170 accelerated crystallization and above which SE S-170 delayed nucleation and growth. The effect of SE S-170 strongly depended on supercooling. It was efficient as a seed for high supercooling (low crystallization temperatures) but this efficiency diminished at low supercooling (temperatures close to the melting point) when few crystals were formed. SAXS and WAXS results demonstrated that depending on crystallization temperature SE S-170 promoted crystallization of &#945; and &#946; forms with more polymorphic similarity and inhibited occurrence of &#946;? forms especially the &#946;?2 polymorph. However, in some conditions SE S-170 favored crystallization of &#946;?1 polymorph. DSC experiments showed that SE S-170 significantly diminished total melting enthalpies when the effect was a delay in crystallization. For other conditions no significant differences were found in melting temperatures or total melting enthalpies. When stearins were stored at 25 °C, crystallization in the &#946;2 form was promoted. Depending on crystallization temperature, polymorphic forms &#946;?1 and &#946;2 may be obtained as the main polymorphic forms. This is very relevant from the technological point of view. Depending on the application, SE S-170 may help obtain the required polymorphic form: &#946;?1 form for spreads and &#946;2 polymorph for chocolate production.","palabras_clave":"sunflower oil stearins|stearic sucrose esters|crystallization|polymorphism"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38969,"idioma_id":4,"titulo":"Measurement of cooling and warming rates in vitrification-based plant cryopreservation protocols","resumen":"Cryopreservation protocols include the use of additives and pre-treatments aimed to reduce the probability of ice nucleation at all temperatures, mainly through micro-viscosity increase. Still, there is a risk of ice formation in the temperature region comprised between the equilibrium freezing (Tf) and the glass transition (TG) temperatures. Consequently, fast cooling and warming, especially in this region, is a must to avoid ice-derived damage. Vitrification and droplet-vitrification techniques, frequently used cryopreservation protocols based in fast cooling, were studied, alongside with the corresponding warming procedures. A very fast data acquisition system, able to read very low temperatures, down to that of liquid nitrogen, was employed. Cooling rates, measured between -20 and -120 ºC, ranged from ca. 5 ºC s-1 to 400 ºC s-1, while warming rates spanned from ca. 2 ºC s-1 to 280 ºC s-1, for the different protocols and conditions studied. A wider measuring window (0 ºC to -150 ºC) produced lower rates for all cases. The cooling and warming rates were also related to the survival observed after the different procedures. Those protocols with the faster rates yielded the highest survival percentages.","palabras_clave":"cooling|warming|rates|vitrification|droplet-vitrification|plant"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38970,"idioma_id":4,"titulo":"Application of chitosan coating on alginate beads for cryopreservation uses","resumen":"Calcium alginate gel beads readily interchange solutes with the bulk solution and water with the surrounding media. The transfer properties are often critical for its use, either for its stability and preservation or textural modulation, or for the convenient treatment of contained tissues for cryopreservation. Chitosan has been evaluated for various uses in food, medical, pharmaceutical, agricultural and chemical industries because of its non-toxic, biocompatible, mucoadhesive, and biodegradable properties. A new approach for chitosan application is analyzed: to both protect against microbial-derived damages and to consider permeability modulation on alginate gel beads employed in cryopreservation. Characterization of combined systems of calcium alginate with chitosan coating should be addressed before including the germplasm tissue. The effect of polysaccharide composition was evaluated on dehydration kinetics. Frozen and unfrozen water fractions for beads with and without chitosan coating were determined by DSC and thermodynamic parameters were calculated. Microstructure was evaluated by SEM, cryo-SEM and FTIR. Results obtained suggest a promising utility of these polysaccharides combination for cryopreservation protocol.","palabras_clave":"alginate|chitosan|beads|cryopreservation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38971,"idioma_id":4,"titulo":"Determination of glassy state by cryo-SEM and DSC in cryopreservation of mint shoot tips by encapsulation-dehydration","resumen":"Cryopreservation of mint shoot tips grown in vitro (Mentha ×piperita) was performed after encapsulation in alginate beads. Encapsulated shoot tips were first pre-cultured in sucrose enriched medium (0.75 M) and then dried under a sterile air flow (0-6 hours). After cooling in liquid nitrogen and warming in a warm water bath, alginate beads were transferred to solid culture medium for 4 weeks. The effect of dehydration time of the encapsulated shoots was evaluated for water content, cooling and warming rates, ice crystal formation and cellular vitrification, by using low-temperature scanning electron microscopy (cryo-SEM) and differential scanning calorimetry (DSC). Viability of the recovered material showed a close relation between the dehydration time, cooling and warming rates, ice formation avoidance and tissue vitrification. At short drying periods (up to 3 hours), ice crystals were formed and the viability was low or absent.  After longer drying periods (5 and 6 hours), both beads and specimens became vitrified.","palabras_clave":"intracellular ice formation|glass transition|cooling rate|viability|calorimetry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38972,"idioma_id":5,"titulo":"Control hormonal de las corrientes de la fase 1 del potencial de acción cardiaco en el síndrome de Brugada","resumen":"Introducción: El síndrome de Brugada es una canalopatía hereditaria con un patrón de transmisión autosómico dominante que presenta una marcado sesgo de genero en la expresión del fenotipo, con una proporción hombre:mujer de 9:1. Un modelo celular de la enfermedad propone una distribución heterogénea de la amplitud de la fase 1 del potencial de acción ventricular como la base para el desarrollo del sustrato arritmogénico.  Objetivos: Hemos investigado el papel de los andrógenos en la regulación de la fase 1 del potencial de acción cardiaco de rata y sus consecuencias electrofisiológicas en un modelo experimental murino del Síndrome de Brugada.  Métodos: Estudiamos el control de la expresión génica por andrógenos en células HL- 1 y en corazones de rata por PCR en tiempo real. Para los estudios de electrofisiología reprodujimos un modelo experimental de síndrome de Brugada en un sistema de Langendorff utilizando solución Tyrode suplementada con pinacidil y terfenadina.   Resultados: El tratamiento de células HL-1 con di-hidro-testosterona produjo un aumento en la expresión de Kv4.3 y NCX. Evaluamos este efecto en ratas tratadas con Testosterona y Finasteride. La expresión de ambos genes fue disminuida por el Finasteride, mientras que la Testosterona aumentó el nivel de ARNm de NCX. La Testosterona produjo un acortamiento del  APD90 y el TTP, lo cual en modelos del SBr se correlaciona con un aumento de la arritmogenicidad. En nuestro modelo, este fenómeno fue observado como un incremento en los potenciales de acción ventriculares ectópicos, esporádicos y sostenidos. La frecuencia de aparición de potenciales de acción ectópicos que se indujo con Terfenadina y Pinacidil en el grupo Control fue reducida en un orden de magnitud por el tratamiento con Finasteride.  Conclusion: Los andrógenos controlan la expresión de componentes clave del potencial de acción cardiaco, resultando en una alteración de la arritmogenicidad. El tratamiento con Finasteride revierte estos efectos.","palabras_clave":"ANDROGENOS|FINASTERIDE|REPOLARIZACION|ARRITMIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38973,"idioma_id":4,"titulo":"Plant-Arthropod interactions in gymnosperm leaves from the Early Permian of Patagonia, Argentina","resumen":"vidence of plant-arthropod interactions in three orders of gymnosperms is documented in at least five localities from Lower Permian strata of the Ri&#769;o Genoa Formation (Patagonia, Argentina). Arthropod damages were identified in Glossopteris, Gangamopteris, Cordaites and Gingkoites leaves, corresponding to four interactive categories: margin feeding, hole feeding, surface feeding, and oviposition. In addition, a Permian insect trace not previously recorded is described on Glossopteris wilsonii leaves. The diversity of arthropod damage is consistent with the diverse flora of the Ri&#769;o Genoa Formation. In turn, the patterns of arthropod and plant-arthropod interaction provide constraints on the ecology and paleoclimate of Western Gondwana during the Early Permian.","palabras_clave":"PLANT ARTHROPOD INTERACTION|GYMNOSPERMS|EARLY PERMIAN|REIO GENOA FORMATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38974,"idioma_id":4,"titulo":"Ticks (Acari: Ixodidae) on wild birds in north-central Argentina","resumen":"Ixodid ticks were collected from wild birds in five ecoregions in north-central Argentina, namely: Selva de las Yungas, Esteros del Iberá, Delta e Islas del Paraná, Selva Paranaense and Chaco Seco. A total of 2,199 birds belonging to 139 species, 106 genera, 31 families and 11 orders were captured, but ticks were collected only from 121 birds (prevalence= 5.5%) belonging to 39 species (28.1%) and three Orders: Tinamiformes (Tinamidae) and Falconiformes (Falconidae) in Selva de las Yungas and Passeriformes (Conopophagidae, Corvidae, Emberizidae, Furnariidae, Icteridae, Parulidae, Thamnophilidae, Thraupidae, Troglodytidae, Turdidae) for all ecoregions. The following tick species were found: Haemaphysalis juxtakochi, Haemaphysalis leporispalustris, Ixodes pararicinus plus Amblyomma sp. and Haemaphysalis sp. in Selva de las Yungas; Amblyomma triste and Ixodes auritulus in Delta e Islas del Paraná; Amblyomma dubitatum, A. triste and Amblyomma sp. in Esteros del Iberá; Amblyomma ovale and Amblyomma sp. in Selva Paranaense, and Amblyomma tigrinum in Chaco Seco. Amblyomma dubitatum was found for the first time on Passeriformes, while the records of A. ovale on avian hosts are the first for Argentina. Birds are also new hosts for I. pararicinus females. Besides 2 larvae and 1 nymph, and 1 larvae found on Tinamidae (Tinamiformes) and Falconidae (Falconiformes), respectively, all other ticks (691 larvae, 74 nymphs and 2 females) were found on Passeriformes with a relevant contribution of the family Turdidae. Birds are important hosts for I. pararicinus as shown by a prevalence of 45% while all others prevalence were below 15%. All the species of Amblyomma and Haemaphysalis found on birds in Argentina have been also detected on humans and are proven or potential vectors for human diseases. Therefore, their avian hosts are probable reservoirs of human pathogens in Argentina.","palabras_clave":"TCIKS|IXODIDAE|AVIAN HOSTS|ECOREGIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38975,"idioma_id":4,"titulo":"Trajectory tracking of a mini four-rotor helicopter in dynamic environments - a linear algebra approach","resumen":"This paper presents the design of a controller that allows a four-rotor helicopter to track a desired trajectory in 3D space. To this aim, a dynamic model obtained from Euler-Lagrange equations describes the robot. This model is represented by numerical methods, with which the control actions for the operation of the system are obtained. The proposed  Controller is simple and presents good performance in face of uncertainties in the model of the system to be controlled. Zero-convergence proof is included, and simulation results show a good performance of the control system.","palabras_clave":"Trajectory tracking|Quadrotor|Numerical methods|Linear algebra"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38976,"idioma_id":4,"titulo":"Gluconacetobacter diazotrophicus Pal5 possesses an active quorum sensing regulatory system","resumen":"The endophytic bacterium Gluconacetobacter diazotrophicus colonizes a broad range of host plants. Its plant growth-promoting capability is related to the capacity to perform biological nitrogen &#64257;xation, the biosynthesis of siderophores, antimicrobial substances and the solubilization of mineral nutrients. Colonization of and survival in these endophytic niche requires a complex regulatory network. Among these, quorum sensing systems (QS) are signaling mechanisms involved in the control of several genes related to microbial interactions, host colonization and stress survival. G. diazotrophicus PAL5 possesses a QS composed of a luxR and a luxI homolog, and produces eightmolecules fromthe AHL family as QS signals. In this report data are provided showing that glucose concentration modi&#64257;es the relative levels of these signal molecules. The activity of G. diazotrophicus PAL5 QS is also altered in presence of other carbon  sources and under saline stress conditions. Inactivation of the QS system of G. diazotrophicus PAL5 by means of a quorum quenching strategy allowed the identi&#64257;cation of extracellular and intracellular proteins under the control of this regulatory mechanism.","palabras_clave":"GLUCONACETOBACTER DIAZOTROPHICUS|QUORUM SENSING|INTERACTION|ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38977,"idioma_id":4,"titulo":"Electron-impact multiple ionization of Ne, Ar, Kr and Xe","resumen":"This work describes the multiple ionization cross sections of rare gases by electron-impact. We pay special attention to the high energy region (0.1?10 keV) where the direct ionization is a minor contribution and the post-collisional electron emission dominates the &#64257;nal target charge  state. We report here electron-impact single to sextuple ionization cross sections and total ionization cross sections including direct and post-collisional processes, even in the total values. We use the continuum distorted wave and the &#64257;rst Born approximations adapted to describe light-particle impact, i.e. energy, mass and trajectory corrections are incorporated, the latter by considering the electron-target potential and by using the Abel transformation. Auger-type post-collisional contributions are included in the multinomial expansion through experimental branching ratios after single ionization events. Tabulations of these experimental branching ratios for all the orbitals of the four targets are included. Present results are compared with the large amount of electron-impact experimental data available. We have obtained a good description of the multiple-ionization measurements at high energies, where the post-collisional ionization dominates. At intermediate energies, our theoretical results show the correct tendency, with the electron-impact ionization cross sections being far below  the proton-impact ones.","palabras_clave":"multiionization|electron|Auger"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38978,"idioma_id":4,"titulo":"HABIT AND ECOLOGY OF THE PETRIELLALES, AN UNUSUAL GROUP OF SEED PLANTS FROM THE TRIASSIC OF GONDWANA","resumen":"Premise of research. Well-preserved Triassic plant fossils from Antarctica yield insights into the physi- ology of plant growth under the seasonal light regimes of warm polar forests, a type of ecosystem without any modern analogue. Among the many well-known Triassic plants from Antarctica is the enigmatic Petriellaea triangulata, a dispersed seedpod structure that is considered a possible homologue of the angiosperm carpel. However, the morphology and physiology of the plants that produced these seedpods have so far remained largely elusive.Methodology. Here, we describe petriellalean stems and leaves in compression and anatomical preser- vation that enable a detailed interpretation of the physiology and ecology of these plants.Pivotal results. Our results indicate that the Petriellales were diminutive, evergreen, shade-adapted pe- rennial shrubs that colonized the understory of the deciduous forest biome of polar Gondwana. This life form is very unlike that of any other known seed-plant group of that time. By contrast, it fits remarkably well into the ?dark and disturbed? niche that some authors considered to have sheltered the rise of the flowering plants some 100 Myr later.Conclusions. The hitherto enigmatic Petriellales are now among the most comprehensively reconstructed groups of extinct seed plants and emerge as promising candidates for elucidating the mysterious origin of the angiosperms.","palabras_clave":"PETRIELLALES|GYMNOSPERMS|TRIASSIC|PALEOECOLOGY|POLAR FORESTS|ANTARCTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38979,"idioma_id":4,"titulo":"Review on pre and post harvest management of peanuts to minimize aflatoxin contamination","resumen":"Peanut or groundnut (Arachis hypogaea L.) is cultivated in the tropical andwarmtemperate regions of the world.Its production reaches approximately 39.9 million metric tons per year. The major producers\/exporters of peanuts are the United States, Argentina, Sudan, Senegal, and Brazil. One of themajor problems in peanut productionworldwide is the contamination with Aspergillus section Flavi and aflatoxins, being these mycotoxins of great concern due to their toxicological effects to human and animals. Different strategies both at pre-harvest and post-harvest stages have been applied to reduce the entry of aflatoxins to the food and feed chains. Nowadays,no single strategy is enough to solve this problem. An integrate management fromthe field until food or feed processing is necessary to reduce the impact of aflatoxins. This review summarizes the advance in reducing the impactof aflatoxins in different countries where peanuts are cultivated.","palabras_clave":"PEANUT|AFLATOXINS |PREHARVEST|PREVENTION|RISK FORECASTING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38980,"idioma_id":4,"titulo":"Hairy black holes sourced by a conformally coupled scalar field in D dimensions","resumen":"There exist well-known no-hair theorems forbidding the existence of hairy black hole solutions in general relativity coupled to a scalar conformal field theory in asymptotically flat space. Even in the presence of cosmological constant, where no-hair theorems can usually be circumvented and black holes with conformal scalar hair were shown to exist in D&#8804;4 dimensions, no-go results were reported for D&gt;4. In this paper we prove that these obstructions can be evaded and we answer in the affirmative a question that remained open: Whether hairy black holes do exist in general relativity sourced by a conformally coupled scalar field in arbitrary dimensions. We find the analytic black hole solution in arbitrary dimension D&gt;4, which exhibits a backreacting scalar hair that is regular everywhere outside and on the horizon. The metric asymptotes to (anti-)de Sitter spacetime at large distance and admits spherical horizon as well as horizon of a different topology. We also find analytic solutions when higher-curvature corrections O(R^n) of arbitrary order n are included in the gravity action.","palabras_clave":"Scalar Hair"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38981,"idioma_id":4,"titulo":"Quasilocal energy for three-dimensional massive gravity solutions with chiral deformations of AdS3 boundary conditions General Relativity and Gravitation","resumen":"We consider critical gravity in three dimensions; that is, the New Massive Gravity theory formulated about Anti-de Sitter (AdS) space with the specific value of the graviton mass for which it results dual to a two-dimensional conformal field theory with vanishing central charge. As it happens with Kerr black holes in four-dimensional critical gravity, in three-dimensional critical gravity the Banados-Teitelboim-Zanelli black holes have vanishing mass and vanishing angular momentum. However, provided suitable asymptotic conditions are chosen, the theory may also admit solutions carrying non-vanishing charges. Here, we give simple examples of exact solutions that exhibit falling-off conditions that are even weaker than those of the so-called Log-gravity. For such solutions, we define the quasilocal stress-tensor and use it to compute conserved charges. Despite the drastic deformation of AdS3 asymptotic, these solutions have finite mass and angular momentum.","palabras_clave":"Black holes|AdS\/CFT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38982,"idioma_id":4,"titulo":"Virulence variation among epidemic and non-epidemic strains of Saint Louis encephalitis virus circulating in Argentina","resumen":"Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina, in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr-4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases.","palabras_clave":"ARBOVIRUS|SAINT LOUIS ENCEPHALITIS VIRUS|FLAVIVIRUS|VIRULENCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38983,"idioma_id":4,"titulo":"NGC 4337: an over-looked old cluster in the inner disc of the Milky Way","resumen":"Galactic   open clusters do not survive long in the high-density regions of the   inner Galactic disc. Inside the solar ring only                       11 open clusters are known with ages older than   1&#8201;Gyr. We show here, basing on deep, high-quality photometry, that NGC   4337,                       contrary to earlier findings, is indeed an old open   cluster. The cluster is located very close to the conspicuous star   cluster                       Trumpler 20, as well misclassified in the past, and   that has received so much attention in recent years. NGC 4337 shows a                       significant clump of He-burning stars which was not   detected previously. Its beautiful colour?magnitude diagram is   strikingly                       similar to the one of the classical old open   clusters IC 4651, NGC 752, and NGC 3680, and this suggests similar age   and composition.                       A spectroscopic study is much needed to confirm our   findings. This, in turn, would also allow us to better define the inner                       disc radial abundance gradient and its temporal   evolution. To this aim, a list of clump star candidates is provided.                                                        ","palabras_clave":"OPEN|CLUSTERS|NGC 4337"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38984,"idioma_id":4,"titulo":"Petrology and Provenance of the Toro Negro Formation (Neogene) of the Vinchina Broken Foreland Basin (central Andes of Argentina)","resumen":"Detrital modes of sandstones and  conglomerates of the Toro Negro Formation (Late Miocene-early Pliocene) were  used to analyze the evolution of the broken-foreland stage of the Vinchina  Basin (28°30?-29°00? S and 68°30?-68°20? W) of NW Argentina. This basin located  in the Western Sierras Pampenas is bounded to the west by the Precordillera and  to the east by the Famatina System. Three sandstone petrofacies: plutonic-metamorphic,  volcanic and mixed petrofacies and three conglomerate lithic associations:  basement, sedimentary and volcanic lithic associations were recognized, allowing  to establish three source areas: Western Sierras Pampeanas (Toro Negro and  Umango Ranges), Cordillera Frontal and Precordillera.During the Late Miocene, the Toro  Negro Range (to the north) together with the Cordillera Frontal and  Precordillera (to the west) were the main sources for depositional sequences I  and II (lower member of the Toro Negro Formation). On the contrary, during the  latest Miocene-early Pliocene, Depositional Sequence III (upper member) exhibited  a progressive increase in the supply from the eastern Precordillera (to the west)  with additional material from the Umango Range to the south. Besides, evidence of  synchronic volcanism is recorded in the upper part of Depositional Sequence II  and the lower part of Depositional Sequence III.The coexistence of the three source  areas and the changing distribution patterns due to re-accommodation of  sediment dispersal routes demonstrate that the evolution of this type of basin  is much more complex than previously envisaged. Therefore, an integrated  analysis using different tools (sedimentary facies, paleocurrent measurements,  sandstone petrography and conglomerate composition) is needed for a clearer understanding  of broken-foreland basins.   ","palabras_clave":"Sedimentary petrology|petrofacies|broken-foreland|Neogene|Andes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38985,"idioma_id":5,"titulo":"'Pero que el camaruco no lo dejen de hacer, pase lo que pase'. Tensiones y (meta)reflexiones sobre las rogativas mapuche?.","resumen":"El presente artículo analiza las tensiones y disputas alrededor de una práctica mapuche de carácter religioso\/sagrado, ejecutada en tanto ceremonia ritual. Específicamente, se enfoca la relevancia que le otorgan al camaruco o nguillatum -según la manera local en que los pobladores denominan a la rogativa. El trabajo de campo se realizó en dos comunidades mapuche, una localizada en la provincia de Neuquén y la otra en Chubut. El objetivo no es abordar la práctica en sí, sino centrarse en la dimensión (meta)reflexiva, siguiendo las evaluaciones que los sujetos realizan, antes, durante y después de la ceremonia. De esta manera, se ubican dos ejes de análisis que se presentan de modo paradojal: el primero centrado en la práctica de evaluar y vincularse críticamente con el evento, donde la categoría nativa ?respeto? indica cómo debe realizarse y cómo se hacía antes. En el segundo eje, se vincula la ceremonia con las transmisiones, la continuidad y la amenaza de la pérdida. A pesar de que no se hace cómo antes y siempre acecha la posibilidad de que se termine, se reafirma aún más el sentido de pertenencia y la importancia de continuar practicando la ceremonia.","palabras_clave":"ROGATIVA MAPUCHE|META-REFLEXIONES|TRANSMISION|PATAGONIA ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38986,"idioma_id":5,"titulo":"Escuela secundaria y nuevas dinámicas de escolarización. Personalización de los vínculos en contextos escolares desiguales","resumen":"Este artículo se basa en los resultados de dos investigaciones que registran cambios en los modos de efectivar la escolarización secundaria de jóvenes provenientes de distintos sectores sociales. Se desarrolla un análisis de las estrategias institucionales de personalización, proceso mediante el cual los profesores realizan un acompa- ñamiento relativamente permanente de la escolarización y el aprendizaje de los estudiantes. Estas dinámicas emergen a partir de las nuevas demandas de inclusión que penden sobre la escuela secundaria en tanto nivel obligatorio del sistema edu- cativo. El análisis aborda instituciones formadoras de élites y escuelas que reciben jóvenes de sectores socioeconómicamente pobres que han quedado excluidos de la secundaria. Así, se indagan continuidades y orientaciones diferenciales que cobran los procesos de personalización de las relaciones entre profesores y alumnos en contextos de desigualdad social.    La revista está indexada en: Red de Revista Científicas de América Latina y El Caribe, España y Portugal (REDALYC) ; Scielo México","palabras_clave":"Educación Secundaria Obligatoria|Enseñanza individualizada|Relación estudiante-profesor|desigualdad sociales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38987,"idioma_id":5,"titulo":"EFECTO DE LA INVASIÓN DE ACACIA NEGRA (Gleditsia triacanthos L. (Fabaceae) SOBRE LA TEMPERATURA, LUZ Y METABOLISMO DE UN ARROYO PAMPEANO","resumen":"El  asentamiento de especies invasoras en una región generalmente produce cambios  en los ecosistemas en los que se introducen. En este caso se analiza el efecto producido  por una invasión de Gleditsia triacanthos,  la acacia negra, sobre un arroyo pampeano. Esta especie modifica el clima  térmico y lumínico del tramo. La amplitud térmica se reduce significativamente  en el tramo invadido aunque la temperatura promedio en ambos tramos es similar.  La irradiación se reduce entre un 85 y un 95 % bajo el dosel arbóreo. Estas  modificaciones disminuyen la producción primaria bruta de 2,7 a 1,7 g O2 \/m2 en  primavera y de 25 a20 g O2  \/m2 en verano. La respiración se reduce a la mitad en los  tramos invadidos tanto en primavera como en verano, siendo el metabolismo neto  similar en ambos tramos y estaciones del año. Por otro lado, el tramo invadido  por acacia tiene muy escasas macrófitas.            Se postula que la  invasión de acacias además de disminuir la biodiversidad por reducción de las  macrófitas y de los organismos asociados a ella reduce la producción primaria  provocando cambios en la red trófica.","palabras_clave":"ARROYOS|INVASORAS LEÑOSAS|METABOLISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38988,"idioma_id":4,"titulo":"Suicide plus immune gene therapy prevents local relapse and increases overall survival in an aggressive mouse melanoma setting","resumen":"In an aggressive B16-F10 murine melanoma model, we evaluated the effectiveness and antitumor mechanisms triggered by a surgery adjuvant treatment that combined a local suicide gene therapy (SG) with a subcutaneous genetic vaccine (Vx) composed by B16-F10 cell extracts and lipoplexes carrying the genes of human interleukin-2 and murine granulocyte and macrophage colony stimulating factor. Pre-surgical SG treatment, neither alone nor combined with Vx was able to slow down the fast evolution of this tumor. After surgery, both SG and SG+Vx treatments, significantly prevented (in 50 % of mice) or delayed (in the remaining 50 %) post-surgical recurrence, as well as significantly prolonged recurrence-free (SG and SG+Vx) and overall median survival (SG+Vx). The treatment induced the generation of a pseudocapsule wrapping and separating the tumor from surrounding host tissue. Both, SG and the subcutaneous Vx, induced this envelope that was absent in the control group. On the other hand, PET scan imaging of SG+Vx group suggested the development of an effective systemic immunostimulation that enhanced 18FDG accrual in thymus, spleen and vertebral column. When combined to surgery, direct intralesional injection of suicide gene plus distal subcutaneous genetic vaccine displayed efficacy and systemic antitumor immune response without host toxicity. This suggests the potential value of the assayed approach for clinical purposes.","palabras_clave":"MELANOMA MURINO|GEN SUICIDA|CITOQUINAS|INMUNOTERAPIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38989,"idioma_id":4,"titulo":"Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1","resumen":"Inflammatory responses are elicited after injury, involving release of inflammatory mediators that ultimately lead, at the molecular level, to the activation of specific transcription factors (TFs; mainly activator protein 1 and nuclear factor-&#954;B). These TFs propagate inflammation by inducing the expression of cytokines and chemokines. The neuroendocrine system has a determinant role in the maintenance of homeostasis, to avoid exacerbated inflammatory responses. Glucocorticoids (GCs) are the key neuroendocrine regulators of the inflammatory response. In this study, we describe the molecular mechanisms involved in the interplay between inflammatory cytokines, the neuroendocrine axis and GCs necessary for the control of inflammation. Targeting and modulation of the glucocorticoid receptor (GR) and its activity is a common therapeutic strategy to reduce pathological signaling. Poly (ADP-ribose) polymerase 1 (PARP1) is an enzyme that catalyzes the addition of PAR on target proteins, a post-translational modification termed PARylation. PARP1 has a central role in transcriptional regulation of inflammatory mediators, both in neuroendocrine tumors and in CNS cells. It is also involved in modulation of several nuclear receptors. Therefore, PARP1 and GR share common inflammatory pathways with antagonic roles in the control of inflammatory processes, which are crucial for the effective maintenance of homeostasis.","palabras_clave":"NEUROENDOCRINOLOGY|INFLAMMATION|GLUCOCORTICOID RECEPTOR|POLY (ADP-RIBOSE) POLYMERASE 1 (PARP1)"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38990,"idioma_id":4,"titulo":"The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune  and neuroendocrine systems","resumen":"Glucocorticoids (GCs), the most downstream effectors of the hypothalamic-pituitary-adrenal (HPA) axis, are key mediators in the interaction between immune and neuroendocrine systems. They exert their biological actions mainly through binding to their intracellular receptor, the glucocorticoid receptor (GR), which in turn influences gene expression by interacting with transcription factors and\/or coregulators. GR abnormal function has been extensively associated to stress-related disorders, inflammatory and autoimmune diseases. Therefore, modulating GR activity is critical to overcome pathological conditions. The final outcome of GCs actions in the immune and neuroendocrine systems is regulated at multiple levels, including post-translational modifications (PTMs) of GR as well as of protein complexes involved in GR signaling. Understanding the influence of PTMs on the molecular mechanisms involved in GR signaling is thus of utmost importance in the search for therapeutic strategies aimed at modulating GR responses under pathophysiological circumstances, and to understand the neuroimmune circuits.","palabras_clave":"Glucocorticoid receptor|post-translational modifications|NEUROIMMUNOLOGY|transcription regulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38991,"idioma_id":4,"titulo":"Cadmium induces two waves of reactive oxygen species in Glycine max (L.) roots","resumen":"Cadmium (Cd) is a non-essential heavy metal that may be toxic or even lethal to plants as it can be easily taken up by the roots and loaded into the xylem to the leaves. Using soybean roots (Glycine maxL.) DM 4800, we have analysed various parameters related to reactive oxygen metabolism and nitric oxide (NO) during a 6 day Cd exposure. A rise in H2O2 and NO, and to a lesser extent O2 &middot;- content was observed after 6h exposure with a concomitant increase in lipid peroxidation and carbonyl group content. Both oxidative markers were significantly reduced after 24h. A second, higher wave of O2 &middot;- production was also observed after 72h of exposure followed by a reduction until the end of the treatment. NOX and glicolate oxidase activity might be involved in the initial Cd-induced reactive oxygen species (ROS) production and it appears that other sources may also participate. The analysis of antioxidative enzymes showed an increase in glutathione-S-transferase activity and in transcript levels and activity of enzymes involved in the ascorbate-glutathione cycle and the NADPH-generating enzymes. These results suggest that soybean is able to respond rapidly to oxidative stress imposed by Cd by improving the availability of NADPH necessary for the ascorbate-glutathione cycle. Different pieces of evidence suggest a role for ROS, and NO in cadmium toxicity, although evolution through the treatment is not so analysed. In this work the response of soybean roots over 6 d Cd treatment was analysed. From the very beginning an increase in ROS and NO production was observed besides an initial oxidative damage on lipids and proteins. Then, the roots recover quickly thanks to the induction of its antioxidant enzymes mainly those involved in the ascorbate-glutathione cycle and the NADPH generating enzymes suggesting a key role for NADPH availability in plant acclimation to Cd stress. &copy; 2014 John Wiley &amp; Sons Ltd.","palabras_clave":"ANTIOXIDANT ENZYMES|CADMIUM|DEHYDROGENASES|NADPH|OXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38992,"idioma_id":4,"titulo":"Noise effect on statistical properties of type-I Intermittency","resumen":"In this work we analyze the noise effect on type-I intermittency, for which we develop a methodology based on a recently proposed technique used to model the reinjection probability density (RPD). This new methodology allows us to study the noise effect on the intermittency statistical properties for relatively large noise strengths in a quadratic map with different reinjection mechanisms. We show that this procedure allows to predict the behavior of the noisy and noiseless system using the results of the M(x) function which is implemented to obtain the RPD function. Wealso derive an analytical approximation for the probability density of the laminar lengths and we obtain results for the average laminar length. All analytical approaches show a good agreement with the numerical results even though the statistical properties are calculated using either the noisy or noiseless data, however in some cases the description of the noiseless system using the noisy data can be inaccurate. In addition, we show that occasionally the presence of noise could be not detected due to the results behave as they would be corresponding to a noiseless system. This aspect may have important consequences especially when working with experimental data.","palabras_clave":"Type I intermittency|noise effect|reinjection probability density"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38993,"idioma_id":5,"titulo":"REGISTRO PALEOAMBIENTAL DEL ESTADIO ISOTÓPICO 2 EN LA PLATAFORMA CONTINENTAL EXTERIOR DEL SURESTE BONAERENSE: UN NUEVO APORTE A LA EVOLUCIÓN REGIONAL","resumen":"Se describe la evolución paleoambiental de la plataforma exterior del sureste bonaerense durante la última parte del Estadio Isotópico 2, a partir del estudio de un testigo a 100 m de profundidad cuya secuencia sedimentaria transgresiva grada desde facies fluvio-estuarinas a facies de barreras-lagunas costeras a ~15 ka cal AP.  ","palabras_clave":"geología marina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38994,"idioma_id":4,"titulo":"Multimatrix measurement of persistent organic pollutants in Mar Chiquita, a continental saline shallow lake","resumen":"RAMSAR sites are determined by specific characteristics of theenvironment in terms of ecological productivity as well services forhuman development, but they are also one of the most threatenedecosystems. Thus, the objective of this work was to evaluate the dynamicof Persistent Organic Pollutants (POPs) in different biotic and abioticmatrixes of the RAMSAR site (wetlands with international importance), MarChiquita Lake. Sampling was performed according to land use(agricultural, urban, and industrial) at two stations: Laguna del Plataand Campo Mare. POPs were analyzed in superficial water (Sw), suspendedparticulate material (SPM), bottom sediment (Bs) and fish tissues(Odontesthes bonariensis). Organochlorine pesticides (OCPs),polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers(PBDEs) were analyzed by GC-ECD. HCHs, Endosulfans, DDTs, PCBs and PBDEswere found in all matrixes at both stations. The high persistence andtransport processes are responsible for the occurrence of HCHs, DDTs andPCBs in Bs, SPM and fish tissues, even many years after theirprohibition. PBDEs showed lower levels according to the scarcity ofpunctual sources in the area. Endosulfan showed variable amounts inagreement with application periods since this pesticide was used until afew years ago in this area. Finally, PCB levels overpassed the acceptabledaily intake for human consumption being a risk for human health Thus,the present report confirm the occurrence of POPs in Mar Chiquita lake,alerting on the contribution of agricultural and urban pollutants in aRAMSAR site. Current results also raise concerns on biomagnificationprocesses through the food web.","palabras_clave":"MAR CHIQUITA|POLYCHLORINATED BIPHENYLS|POLYBROMINATED DIPHENYL ETHERS|ORGANOCHLORINE PESTICIDES|ODONTESTHES BONARIENSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38995,"idioma_id":4,"titulo":"Assessment of persistent organic pollutants accumulation and lipid peroxidation in two reproductive stages of wild silverside (Odontesthes bonariensis)","resumen":"Persistent organic pollutants (POPs) in streamwater can sometimes exceed the guidelines values reported for  biota and human protection in watersheds with intensive agriculture. Oxidative stress and cytotoxicity are  some of the markers of exposure to POPs in &#64257;sh. Accumulation of organochlorine pesticides (OCPs),  polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) as well as lipid peroxidation  (LPO) was assessed in wild silverside (Odontesthes bonariensis) from maturation and pre-spawning stages  sampled in a typical soybean growing area. Pollutants were quanti&#64257;ed by gas chromatography with electron  capture detection and LPO by the method of thiobarbituric acid reactive substances. Concentrations of POPs  were in the following order: OCPs4PCBs4PBDEs in all organs and stages. Liver, gills and gonads had the  highest OCP concentrations in both sexes and stages with a predominance of endosulfan in all samples.  Matured individuals, sampled after endosulfan application period, showed higher endosulfan concentrations  than pre-spawning individuals. The predominance of endosulfan sulfate could be due to direct uptake from  diet and water column, as well as to the metabolism of the parent compounds in &#64257;sh. The prevalence of  p,p??-DDE in liver would also re&#64258;ect both the direct uptake and the metabolic transformation of p,p??-DDT to  p,p??-DDE by &#64257;sh. The highest levels of PBDEs and PCBs were found in gills and brain of both stages of growth.  The pattern BDE-474BDE-100 in all samples corresponds to pentaBDE exposure. In the case of PCBs, penta  (#101 and 110) and hexa-CB congeners (#153 and 138) dominated in the maturation stages and tri (#18) and  tetra-CB (#44 and 52) in pre-spawning stages, suggesting biotransformation or preferential accumulation of  heavier congeners during gonadal development. Differences in LPO levels in ovaries were associated with  growth dilution and reproductive stage. Differences in LPO levels in gills were related with pesticide  application periods. As a whole, endosulfan, a current-use pesticide, constituted the main pollutant found in  wild silverside re&#64258;ecting the intense agriculture activity in the study area. Moreover endosulfan was  positively correlated with LPO.","palabras_clave":"peces|contaminacion|Rio Quequen Grande|POPs"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38996,"idioma_id":4,"titulo":"Antioxidant, phase II and III responses induced by lipoic acid in the fish Jenynsia multidentata (Anablapidae) and its influence on endolsulfan accumulation and toxicity","resumen":"Antioxidants like lipoic acid (LA) are known to trigger augmented antioxidant and phase II and III responses. This study aimed to evaluate the effect of LA in P-glycoprotein (Pgp) expression, glutathione-S-transferase (GST) activity, total antioxidant competence, levels of lipid peroxides (TBARS) and accumulation of the organochlorine insecticide endosulfan (Endo:a-,b-isomers and sulfate metabolite)in different organs of the fishJenynsia multidentata. One hundred and twenty females (1.55 ± 0.07 g) were fed during 8 days with (n= 60) or without (n= 60) a LA enriched ration (6000 mg\/kg). Four experimentalgroups were defined:LA\/Endo; +LA\/Endo;LA\/+Endo; and +LA\/+Endo. Endo groups were exposed during 24 h to 1.4lg of insecticide\/L. Results showed that only LA induced a significant increment in liverPgp expression. GST activity was augmented in liver after exposure to LA or Endo. TBARS levels were lowered in liver and gills after LA pre-treatment. Total antioxidant capacity was lowered in liver of Endoexposed fish, a result that was reversed by LA pre-treatment. It is concluded that LA induced the expected effects in terms of Pgp expression, GST activity and reduced TBARS levels although favoreda-Endo accumulation in brain. However, the Endo metabolism to the more persistent endosulfan sulfate was not facilitated by LA pre-treatment.","palabras_clave":"estres oxidativo|peces|endosulf&#225;n"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38997,"idioma_id":5,"titulo":"Iniciativas para la retención, la enseñanza y los aprendizajes en el primer año de la secundaria. El caso de las parejas pedagógicas y las tutorías en la Ciudad de Buenos Aires","resumen":"Tras la extensión de la obligatoriedad de la educación secundaria en la Ciudad de Buenos Aires y en el país, la investigación en la que se inscribe este artículo analiza los modos en que los actores escolares, en diversos contextos y en el marco de las políticas nacionales, jurisdiccionales e institucionales de apoyo a las trayectorias educativas de los estudiantes, despliegan iniciativas dirigidas a promover la retención y a apoyar la enseñanza y los aprendizajes en el primer año de la escuela secundaria. El estudio se desarrolla desde el área de investigación del Ministerio de Educación jurisdiccional y su estrategia metodológica es cualitativa, con recopilación de documentos y entrevistas realizadas a directores, docentes y estudiantes de once escuelas estatales de la Ciudad de Buenos Aires. El artículo despliega, en primer lugar, una clasificación de las experiencias encontradas considerando su propósito central, a saber: a) fortalecimiento de las propuestas de enseñanza, b) apoyo y seguimiento de los aprendizajes, c) construcción del involucramiento escolar y de la convivencia; y d) abordaje de temáticas de relevancia para los adolescentes. En segundo lugar, a partir de ese mapa de iniciativas, se hace foco en dos de los dispositivos vinculados con estos propósitos: las tutorías y las parejas pedagógicas.","palabras_clave":"inclusión|pareja pedagógica|tutorías|proyectos institucionales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38998,"idioma_id":4,"titulo":"Ballistic transport properties in pristine\/doped\/ pristine graphene junctions","resumen":"We investigate the ballistic electron transport in a monolayer graphene with configurational averaged impurities, located between two clean graphene leads. It is shown that the electron transmission are strongly dependent on the concentration of impurities and the incident energy. In turn, the conductance computed using the Landauer formalism shows a similar behavior to those found in experimental works as a function of the applied voltage for different concentrations of impurities in the limit of low temperatures. In the limit of zero bias voltage, the conductance shows a minimum value which reduces to zero for high concentration of impurities which disentangle graphene sublattices. These results can be very helpful for exploring the tunneling mechanism of electrons through doped thermodynamically stable graphene.","palabras_clave":"GRAPHENE|TIGHT  BINDING|IMPURITIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":38999,"idioma_id":4,"titulo":"EFFECTS OF CADMIUM STRESS ON GROWTH, ANATOMY AND HORMONE CONTENTS IN GLYCINE MAX (L) MERR","resumen":"Changes in growth parameters, root and leaf anatomy, and stress hormone contents in Cd-stressed soybean (Glycine max L.) seedlings were investigated. Under treatment with 40&nbsp;&micro;M CdCl2, the whole plant, root and leaf FW and DW significantly decreased. Also, the whole plant and root length decreased, as well as the chlorophyll and carotenoid contents. This heavy metal affected root and leaf anatomy. In comparison to control, root diameter increased as a consequence of the greater size of the cortex and the vascular cylinder area, and vascular tissues were markedly affected by Cd. In leaflets, the curvature of the mesophyll in internerval areas was observed after Cd treatment. Cd also affected the mesophyll thickness which was reduced by the presence of shorter and narrower cells of the palisade parenchyma. Jasmonic acid content dropped dramatically in Cd-stressed roots, meanwhile ABA and metabolites increased at different times of Cd stress suggesting their involvement in Cd response. ABA peaked at 24&nbsp;h of Cd stress whereas a strong peak of ABA-GE appeared immediately after the ABA peak. DPA started increasing at 6&nbsp;h of Cd treatment and the highest peak was recorded at 24&nbsp;h, as well as the ABA peak. The DPA and ABA-GE contents were higher than the ABA ones Therefore, the alterations induced by the Cd-phytotoxic effect on the growth and anatomy of the soybean seedlings as well as on the ABA and JA root content suggest a possible involvement of these hormones on the sensing and response mediation of these compounds in the organ that first senses the stress.","palabras_clave":"CADMIUM |STRESS |GROWTH|HORMONE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39000,"idioma_id":4,"titulo":"Signature of Nonadiabatic coupling in excited state vibrational modes","resumen":"Using analytical excited-state gradients, vibrational normal modes have been calculated at the minimum of the electronic excited-state potential energy surfaces for a set of extended conjugated molecules with dierent coupling between them. Molecular model systems composed of units of polyphenylene ethynylene (PPE), polyphenylene vinylene (PPV), and naphthacene\/pentacene (NP) have been considered. In all cases except the NP model, the inuence of the nonadiabatic coupling on the excited-state equilibrium normal modes is revealed as a unique highest frequency adiabatic vibrational mode that overlaps with the coupling vector. This feature is removed by using a locally diabatic representation in which the eect of NA interaction is removed. Comparison of the original adiabatic modes with a set of vibrational modes computed in the locally diabatic representation demonstrates that the eect of nonadiabaticity is conned to only a few modes. This suggests that the nonadiabatic character of a molecular system may be detected spectroscopically by identifying these unique state-specic high frequency vibrational modes.","palabras_clave":"normal modes|excited states|conjugated molecules"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39001,"idioma_id":4,"titulo":"Unraveling the differences of the hydrolytic activity of Trypanosoma cruzi trans-Sialidase and Trypanosoma rangeli Sialidase: A QM\/MM modeling study","resumen":"Chagas? disease, also known as American trypanosomiasis, is a lethal, chronic disease that currently affects more than 10 million people in Central and South America. The transsialidase from T.cruzi (TcTS) is a crucial enzyme for the survival of this parasite: sialic acids  from the host are transferred to the cell surface glycoproteins of the trypanosome, thereby evading the host?s immune system. On the other hand, the sialidase of Trypanosoma rangeli (TrSA), which shares 70% sequence identity with TcTS, is a strict hydrolase and shows no transsialidase activity. Therefore, TcTS and TrSA represent an excellent framework to understand how different catalytic activities can be achieved with extremely similar structures. By means of combined quantum mechanics-molecular mechanics (QM\/MM, SCC-DFTB\/Amberff99SB) calculations and umbrella sampling simulations, we investigated the hydrolysis mechanisms of TcTS and TrSA and computed the free energy profiles of these reactions. The results, together with our previous computational investigations, are able to explain the catalytic mechanism of  sialidases and describe how subtle differences in the active site make TrSA a strict hydrolase and TcTS a more efficient trans-sialidase.","palabras_clave":"QMMM|UMBRELLA|CATALYSIS|SIALIDASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39002,"idioma_id":4,"titulo":"Exchange protein activated by cyclic AMP is involved in the regulation of adipogenic genes during 3T3-L1 fibroblasts differentiation","resumen":"Adipogenesis is stimulated in 3T3-L1 fibroblasts by a combination of insulin, dexamethasone and isobutylmethylxanthine, IBMX, (I+D+M). Two transcription factors are important for the acquisition of the adipocyte phenotype, C\/EBP beta (CCAT enhancer-binding protein beta) and PPAR gamma (peroxisome proliferator-activated receptor gamma). IBMX increases cAMP content, which can activate protein kinase A (PKA) and\/or EPAC (exchange protein activated by cAMP). To investigate the importance of IBMX in the differentiation mixture, we first evaluated the effect of the addition of IBMX on the increase of C\/EBP beta and PPAR gamma and found an enhancement of the amount of both proteins. IBMX addition (I+D+M) or its replacement with a cAMP analogue, dibutyryl-cAMP or 8-(4-chlorophenylthio)-2-O&#8242;-methyl-cAMP (8CPT-2-Me-cAMP), the latter activates EPAC and not PKA, remarkably increased PPAR gamma mRNA. However, neither I+D nor any of the inducers alone, increased PPAR gamma mRNA to a similar extent, suggesting the importance of the presence of both IBMX and I+D. It was also found that the addition of IBMX or 8CPT-2-Me-cAMP was able to increase the content of C\/EBP beta with respect to I+D. In agreement with these findings, a microarray analysis showed that the presence of either 8CPT-2-Me-cAMP or IBMX in the differentiation mixture was able to upregulate PPAR gamma and PPAR gamma-activated genes as well as other genes involved in lipid metabolism. Our results prove the involvement of IBMX-cAMP-EPAC in the regulation of adipogenic genes during differentiation of 3T3-L1 fibroblasts and therfore contributes to elucidate the role of cyclic AMP in this process.&nbsp;","palabras_clave":"3T3-L1 CELLS|ADIPOGENESIS|C-EBP BETA|CYCLIC AMP|PPAR GAMMA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39003,"idioma_id":4,"titulo":"Tempol blunts afferent arteriolar remodeling in chronic nitric oxide-deficient hypertension without normalizing blood pressure","resumen":"  BACKGROUND\/AIM:   Renal preglomerular vessels   play a central role in modulating renal function and injury, especially   during conditions of renal hemodynamic stress such as hypertension. We evaluated whether improving the balance between nitric oxide (NO) and oxidative stress improves the morphological alterations of renal afferent arterioles that occur in NO deficiency-induced hypertension.  METHODS:   We measured indices of NO and oxidative stress and evaluated renal morphology and afferent arteriolar remodeling in rats treated with vehicle, L-NAME or L-NAME plus tempol (a superoxide dismutase mimetic) for 6 weeks.  RESULTS:   L-NAME-treated rats had hypertension,   lower urinary and renal NO indices, higher renal cortical levels of   TBARS, GSSG and GSSG\/GSH. This was associated with significant eutrophic   inward remodeling of the afferent arterioles; they had a marked decrease in arteriolar lumen area and a striking increase in arteriolar wall thickness and media to lumen ratio. Tempol did not significantly reduce blood pressure, but increased NO levels, decreased oxidative stress and partially blunted L-NAME-induced remodeling of afferent arterioles.  CONCLUSION:   L-NAME-induced remodeling of afferent arterioles is blunted by tempol. This beneficial effect on remodeling is associated with increases in NO indices, decreases in oxidative stress, without significant decreases in blood pressure. Thus, the balance between these components may contribute to the altered renal hemodynamics and function in this model.","palabras_clave":"Afferent arteriole|hypertension|nitric oxide|oxidative stress|remodeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39004,"idioma_id":4,"titulo":"The Chañares Formation: a window to a Middle Triassic tetrapod community","resumen":"The Chañares Formation is known worldwide for its diverse and well-preserved Ladinian non-marine tetrapod assemblage, including a wide variety of archosauriform reptiles (proterochampsids, early offshoots of the crocodilian line, and dinosaurian precursors) and synapsids represented by dicynodonts and cynodonts. This tetrapod   cord offers an opportunity to evaluate, within a taphonomic context, the palaeoecology of this Middle Triassic fauna. The taphonomic analysis of the Chañares ssemblage, under precise stratigraphic control, indicates that it is a good representation of the original faunal composition allowing us to address the paleoecological interactions between its components. Mass estimations and morphology-based paleobiological inferences of Chañares tetrapods are used to reconstruct the trophic structure of the community. Chañares tetrapod fauna was numerically dominated by middle-sized herbivorous and small faunivorous cynodonts, whereas middle-sized faunivorous cynodonts and large dicynodonts were less common. In contrast to the therapsids, which show a low species richness and high abundance, the archosauriforms are less abundant but are the most taxonomically diverse group. The large paracrocodylomorphs (estimated body masses between 350 and 500 kg) are identified as the top-predators of the community and the traversodontid cynodonts and dicynodonts (estimated body masses reaching approximately 43 and 360 kg, respectively) are indentified as the base herbivores of the trophic pyramid. We conclude that the worldwide faunal composition in the Ladinian reveals two continentalassemblages: (a) an eastern Laurasian assemblage dominated by temnospondyl amphibians; and (b) a western Gondwanan assemblage dominated by therapsids but including a wide diversity of archosauriforms","palabras_clave":"Taphonomy|Ladinian Faunas|Chañares Formation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39005,"idioma_id":5,"titulo":"PALEODIETAS HUMANAS EN EL SUR DEL GOLFO SAN JORGE (PROVINCIA DE SANTA CRUZ) A PARTIR DEL ANÁLISIS DE ISÓTOPOS ESTABLES","resumen":"A partir de datos cronológicos y de isotopos estables de Delta 15N y Delta13C de colágeno se explora la importancia relativa del consumo de recursos marinos y recursos terrestres en la dieta de los cazadores recolectores durante el Holoceno Tardío. Para este estudio te utilizo una colección osteologica depositada en el Museo del Hombre y su Entorno de Caleta Olivia, la cual fuera previamente puesta en valor y adecuada en su repositorio.","palabras_clave":"PATAGONIA SUR|CAZADORES RECOLECTORES|HOLOCENO TARDIO|COLECCIONES OSTEOLOGICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39006,"idioma_id":5,"titulo":"Paleodietas humanas en la costa patagónica durante el Holoceno tardío. Nuevos datos de isótopos estables y fechados radiocarbónicos para la costa centro-sur","resumen":"El objetivo de este trabajo es presentar datos de isótopos estables de la fracción colagénica (&#948;13C y &#948;15N) y fechados radiocarbónicos de una muestra de restos óseos humanos de la costa sur de la actual provincia del Chubut. Los datos obtenidos se discuten en términos de paleodietas en el contexto de investigaciones previas y datos disponibles para el resto de la costa atlántica patagónica. La expectativa inicial fue hallar dietas caracterizadas por un consumo mixto de recursos (i.e. marinos y terrestres). Sin embargo, sólo una de las muestras analizadas sugiere el consumo de recursos marinos, cuya antigüedad es de 2531 ± 45 años AP. Las restantes indican un consumo de recursos predominantemente terrestres con valores semejantes a los relevados en el interior patagónico. Con este trabajo se espera aportar a la discusión regional sobre paleodietas  humanas entre los grupos cazadores-recolectores de la costa durante el Holoceno tardío.","palabras_clave":"ISÓTOPOS ESTABLES|COSTA SUR DE CHUBUT|HOLOCENO TARDIO|PALEODIETAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39007,"idioma_id":4,"titulo":"Depletion of Circulating Regulatory T Cells during Severe Respiratory Syncytial Virus Infection in Young Children","resumen":"Respiratory syncytial virus (RSV) is the main cause of viral lowerrespiratory tract illness ininfancyandearly childhood.Eachyear,RSVisestimated to cause 34 million cases of lung infection and the deathsofupto199,000 childrenless than5 yearsof ageworldwide.Childrenareusually infected by RSV during the first year of life, and virtually allby 3 years of age. Although in most cases the infection induces mildillness of the upper airways, 2 to 5% experience a severe bronchiolitisthat requires hospitalization and respiratory support in an intensive care unit. These patients show later a high susceptibility to developrecurrent wheeze and asthma","palabras_clave":"RESPIRATORY INFECTIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39008,"idioma_id":4,"titulo":"Free energy computations identify the mutations required to confer trans-sialidase activity into Trypanosoma rangeli Sialidase","resumen":"Trypanosoma rangeli´s sialidase (TrSA) and Trypanosoma cruzi´s trans-sialidase (TcTS) are members of the glycoside hydrolase family 33 (GH-33). They share 70% of sequence identity and their crystallographic C_alfa-rmsd is 0.59 Å. In spite of these similarities they catalyze different reactions. TcTS transfers sialic acid between glycoconjugates while TrSA can only cleave sialic acid from sialyl-glyconjugates. Significant effort has been invested into unraveling the differences between TrSA and TcTS, and into conferring TrSA with trans-sialidase activity through appropriate point mutations. Recently, we calculated the free energy change for the formation of the covalent intermediate (CI) in TcTS and performed an energy decomposition analysis of that process. In this article we present a similar study for the formation of the CI in TrSA, as well as in a quintuple mutant (TrSA5mut), which has faint trans-sialidase activity. The comparison of these new results with those previously obtained for TcTS allowed identifying five extra mutations to be introduced in TrSA5mut that should create a mutant (TrSA10mut) with trans-sialidase activity.","palabras_clave":"MOLECULAR DYNAMICS|TRANS-SIALIDASE|SIALIDASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39009,"idioma_id":4,"titulo":"Glycans and Galectins in prostate cancer biology, angiogenesis  and metastasis","resumen":"Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. While localized prostate cancer can be cured, advanced and metastatic prostate cancer remains a significant therapeutic challenge. Malignant transformation is associated with important modifications of the cellular glycosylation profile, and it is postulated that these changes have a considerable relevance for tumor biology. Metastasis is a multiphasic process that encompasses angiogenesis, the spread of tumor cells and their growth at distant sites from the primary tumor location. Recognition of glycoconjugates by galectins, amongst other lectins, plays a fundamental role in the metastatic spread, tumor immune escape and the neovascularization process. Particularly in prostate cancer, both carbohydrates and galectins have been implicated in many cellular processes such as proliferation, apoptosis, migration and invasion. However, a limited number of studies assessed their potential implications in the induction of metastasis in prostate cancer patients or in animal models. Moreover, the role of galectin-glycan interactions in vivo still remains poorly understood; concerted effort should thus be made in order to shed some light on this question. This review summarizes current evidence on both the expression and role of glycans and galectins in prostate cancer, particularly turning our attention to the angiogenic and metastatic processes.","palabras_clave":"Galectins|prostate cancer|cancer microenvironment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39010,"idioma_id":4,"titulo":"Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development.","resumen":"BACKGROUND:  Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which these factors dynamically regulate the expression of their target genes at different developmental stages are still poorly understood.  RESULTS:  We characterized the relationship of chromatin accessibility, gene expression and DNA-binding of two MADS-domain proteins at different stages of Arabidopsis flower development. Dynamic changes in APETALA1 and SEPALLATA3 DNA-binding correlated with changes in gene expression, and many of the target genes could be associated with the developmental stage in which they are transcriptionally controlled. We also observe dynamic changes in chromatin accessibility during flower development. Remarkably, DNA-binding of APETALA1 and SEPALLATA3 is largely independent of the accessibility status of their binding regions and it can precede increases in DNA accessibility. These results suggest that APETALA1 and SEPALLATA3 may modulate chromatin accessibility, thereby facilitating access of other transcriptional regulators to their target genes.  CONCLUSIONS:  Our findings indicate that different homeotic factors regulate partly overlapping, yet also distinctive sets of target genes in a partly stage-specific fashion. By combining the information from DNA-binding and gene expression data, we are able to propose models of stage-specific regulatory interactions, thereby addressing dynamics of regulatory networks throughout flower development. Furthermore, MADS-domain TFs may regulate gene expression by alternative strategies, one of which is modulation of chromatin accessibility.","palabras_clave":"Plant|Flower development|MADS transcriptional factors|chromatin accessibility"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39011,"idioma_id":4,"titulo":"StRemorin1.3 hampers Potato virus X TGBp1 ability to increase plasmodesmata permeability, but does not interfere with its silencing suppressor activity","resumen":"TThe Triple Gene Block 1 (TGBp1) protein encoded by the Potato virus X is a multifunctional protein  that acts as a suppressor of RNA silencing or facilitates the passage of virus from cell to cell by  promoting the plasmodesmata opening. We previously showed that the membrane raft protein  StRemorin1.3 is able to impair PVX infection. Here, we show that overexpressed StRemorin1.3 does  not impair the silencing suppressor activity of TGBp1, but affects its ability to increase plasmodesmata  permeability. A similar effect on plasmodesmata permeability was observed with other movement  proteins, suggesting that REM is a general regulator of plasmodesmal size exclusion limit.  These results add to our knowledge of the mechanisms underlying the StREM1.3 role in virus  infection.","palabras_clave":"REMORIN|TGBp1|GATING|PTGS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39012,"idioma_id":4,"titulo":"Determination of Strouhal Numbers at High Reynolds Numbers","resumen":"Leeward of natural elevations, like mountains and hills, the air flow becomes turbulent and often times damaging and hazardous to aviation and downwind populations. There is currently a trend for massive construction projects, the result of which are megastructures that behave similarly to these natural elevations and create analogous turbulence conditions. Examples five mega projects were analyzed, and it was estimated that the Reynolds number variation in these buildings, is from 6.108 and 7.109, for winds between 10 m\/s and 50 m\/s. In this work, the authors present a first numerical approach to this phenomenon by calculating the Strouhal numbers induced by winds blowing against large-volume bodies, in the range of high Reynolds numbers. For this study, satellite images depicting von Kármán cloud streets leeward of isolated islands were used. The methodology employed was based on a satellite image where streets watch von Kármán vortex, from National Oceanic and Atmospheric Administration - Air Resource Laboratory (NOAA-ARL) prognosis was obtained for a grid point near the island, then determined the inversion layer and meteorological data (wind, temperature and pressure), were measured from the satellite image the distances separating the vortices to calculate the period, the Reynolds number and Strouhal. The studied results of the cases are displayed graphically, where it is possible to observe a data dispersion as well as a rising trend of the Strouhal number as the Reynolds number increases.","palabras_clave":"vórtices|Reynolds|Strouhal|edificios"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39013,"idioma_id":4,"titulo":"THE INFLUENCE OF PRE-ADSORBED Pt ON HYDROGEN  ADSORPTION ON B2 FeTi(111)","resumen":"The hydrogen adsorption properties on a Pt covered Fe-terminated B2-FeTi (111) surface are studied using the Density Functional Theory (DFT). The calculations are employed to trace relevant orbital interactions and to discuss the geometric and electronic consequences of incorporating one Pt atom or a Pt monolayer on top of the FeTi surface. The most stable adsorption site is a distorted FCC hollow for one Pt atom and from this location we build the Pt monolayer (ML). The H-adsorption energy is very close among BRIDGE, HCP and FCC hollow sites (w-0.45 eV) being lower for the TOP site (-0.34 eV) in the case of a Pt  (111) fcc surface. In the case of a Pt ML\/FeTi, the H more stabilized on a BRIDGE site (-1.13 eV) interacting with both a Pt and Fe atom. We also computed the density of states (DOS) and the overlap population density of states (OPDOS) in order to study the evolution of the chemical bonding after adsorption.","palabras_clave":"Hydrogen|Adsorption|B2-FeTi|Platinum"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39014,"idioma_id":4,"titulo":"Hydrogen adsorption on PdGa(100), (111) and (-1,-1,-1 ) surfaces: A DFT study","resumen":"Hydrogen adsorption on PdGa intermetallic compound is analyzed using density functional theory (DFT) calculations. Changes in the electronic structure of PdGa(100), (111) and (-1-1-1) surfaces and H bonding after adsorption are addressed. H interacts with Pd atoms with a tilted geometry on (100) and (111) surfaces. On the (-1-1-1) surface two possible forms for H adsorption are detected: one is observed atop perpendicular to the surface and the other one is subsuperficial, both with similar adsorption energies. The Ga-H interaction is energetically less stable and is only present on the (100) plane. Pd-Pd bond strength decreases up to 53.8 % as the new Pd-H bond is formed. The Pd-H bond length differs less than 1%, compared to the gas phase value for the (100), (111) and atop (-1-1-1). However in the (-1-1-1) subsurface-H bond length is about 2.17 Å. The effect of H is limited to its first Pd neighbor. Analysis of orbital interaction reveals that the Pd-H bond mainly involves s-s and s-p orbitals with lower participation of Pd 4d orbitals. The computed H vibration frequencies after adsorption show values of 1786, 1289 and 633.5 cm^-1 that correspond to top, bridge and hollow sites respectively.","palabras_clave":"PDGA|DFT|INTERMETALLIC COMPOUNDS|HYDROGEN ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39015,"idioma_id":4,"titulo":"Post-transcriptional control of GRF transcription factors by microRNA miR396 and GIF co-activator affects leaf size and longevity","resumen":"The growth-regulating factors (GRFs) are plant-specific transcription factors. They form complexes with GRF-interacting factors (GIFs), a small family of transcriptional co-activators. In Arabidopsis thaliana, seven out of the nine GRFs are controlled by microRNA miR396. Analysis of Arabidopsis plants carrying a GRF3 allele insensitive to miR396 revealed a strong boost in the number of cells in leaves, which was further enhanced synergistically by an additional increase of GIF1 levels. Genetic experiments revealed that GRF3 can still increase cell number in gif1 mutants, albeit to a much lesser extent. Genome-wide transcript profiling indicated that the simultaneous increase of GRF3 and GIF1 levels causes additional effects in gene expression compared to either of the transgenes alone. We observed that GIF1 interacts in vivo with GRF3, as well as with chromatin-remodeling complexes, providing a mechanistic explanation for the synergistic activities of a GRF3-GIF1 complex. Interestingly, we found that, in addition to the leaf size, the GRF system also affects the organ longevity. Genetic and molecular analysis revealed that the functions of GRFs in leaf growth and senescence can be uncoupled, demonstrating that the miR396-GRF-GIF network impinges on different stages of leaf development. Our results integrate the post-transcriptional control of the GRF transcription factors with the progression of leaf development.","palabras_clave":"microRNA|development|senescence|arabidopsis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39016,"idioma_id":5,"titulo":"'Presentación'","resumen":"Este número especial de la Revista Controversias y Concurrencias  Latinoamericanas, de la Asociación Latinoamericana de Sociología (ALAS) y del  Journal of Latin American Communication Research (JLACR), de la Asociación  Latinoamericana de Investigadores de la Comunicación (ALAIC), es fruto de una  relación de cooperación que se viene desarrollando desde el Congreso de ALAS en  Recife (2011), cuando se organizó una primera mesa ALAS-ALAIC, que se  extendería en el 2012 para una acción coordinada en el interior del RC14 de la  International Sociological Association (ISA), en Buenos Aires. Una segunda mesa  ALAS-ALAIC se realizó también en el 2012, en el congreso de ALAIC en  Montevideo, y una tercera en ALAS, Santiago de Chile, 2013","palabras_clave":"Pensamiento crítico|Sociología|Comunicación|Latinoamérica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39017,"idioma_id":5,"titulo":"LA GESTIÓN DEL CAPITAL HUMANO EN LAS MiPyMEs  DE ALOJAMIENTO TURÍSTICO DE LA CIUDAD AUTÓNOMA DE BUENOS AIRES - ARGENTINA","resumen":"En este trabajo se realiza un análisis de la problemática de la gestión del  capital humano vinculado a las MiPyMEs de alojamiento turístico de la Ciudad  Autónoma de Buenos Aires, recogiéndose los principales aportes de los  trabajos más relevantes en la materia. Asimismo, se extraen conclusiones que  permiten determinar las circunstancias bajo las cuales se puede considerar  estratégica la gestión del capital humano e intelectual. Se ha realizado un  análisis descriptivo de algunos aspectos relevantes de la gestión de los  recursos humanos, como la formación y el desarrollo de sus trabajadores y  directivos, la estabilidad laboral y la estructura de propiedad.","palabras_clave":"Capital humano|gestión|alojamiento turistico|MiPyMEs"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39018,"idioma_id":4,"titulo":"Structures and host-adhesion mechanisms of lactococcal siphophages","resumen":"The Siphoviridae family of bacteriophages is the largest viral family on earth and comprises members infecting both bacteria and archaea. Lactococcal siphophages infect the Gram-positive bacterium Lactococcus lactis, which is widely used for industrial milk fermentation processes (e.g., cheese production). As a result, lactococcal phages have become one of the most thoroughly characterized class of phages from a genomic standpoint. They exhibit amazing and intriguing characteristics. First, each phage has a strict specificity toward a unique or a handful of L. lactis host strains. Second, most lactococcal phages possess a large organelle at their tail tip (termed the baseplate), bearing the receptor binding proteins (RBPs) and mediating host adsorption. The recent accumulation of structural and functional data revealed the modular structure of their building blocks, their different mechanisms of activation and the fine specificity of their RBPs. These results also illustrate similarities and differences between lactococcal Siphoviridae and Gram-negative infecting Myoviridae.","palabras_clave":"Lactococcus lactis|Siphoviridae|crystal structure|electron microscopy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39019,"idioma_id":4,"titulo":"CryoEM structure of the lactococcal siphophage 1358 virion","resumen":"Lactococcus lactis, a Gram+ lactic acid-producing bacterium used for the manufacture of several fermented dairy products, is subject to infection by diverse virulent tailed phages, leading to industrial fermentation failures. This constant viral risk has led to a sustained interest in the study of their biology, diversity and evolution. Lactococcal phages now constitute a wide ensemble of at least 10 distinct genotypes within the Caudovirales order, many of them belonging to the Siphoviridae family. Lactococcal siphophage 1358, currently the unique member of its group, displays a noticeably high genomic similarity to some Listeria phages as well as a host range limited to a few L. lactis strains. These genomic and functional characteristics stimulated our interest for this phage. Here, we report the cryo electron microscopy structure of the complete 1358 virion. Phage 1358 exhibits noteworthy features such as a capsid with dextro handedness and protruding decorations on its capsid and tail. Observations of the baseplate of virion particles revealed at least two conformations, a closed and an open 'activated' form. Functional assays uncovered that the adsorption of phage 1358 to its host is Ca++ independent, but this cation is necessary to complete its lytic cycle. Taken together, our results provide the complete structural picture of a unique lactococcal phage and expand our knowledge on the complex baseplate of phages of the Siphoviridae family.","palabras_clave":"CryoEM|STRUCTURE|1358|ELECTRON MICROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39020,"idioma_id":5,"titulo":"Caracterización  genética  de  germoplasma  de maní cultivado (Arachis hypogaea L.) mediante el empleo de marcadores microsatélites","resumen":"El maní cultivado (Arachis  hypogaea L.),es una especie de gran importancia económica,nativo  de América del Sur. Se divide en dos subespecies y seis variedades botánicas. Genéticamente  es alotetraploide, constituido por dos juegos genómicos duplicados. El empleo  de marcadores microsatélites resulta más apropiado para realizar la caracterización  genética de esta especie, puesto que permiten detectar un elevado nivel de  polimorfismo. El objetivo del presente trabajo fue caracterizar la diversidad  genética existente en las entradas de germoplasma de maní cultivado  pertenecientes al Banco Activo de Germoplasma de Maní del Instituto Nacional de  Tecnología Agropecuaria (INTA). Veinticinco entradas fueron genotipificadas con  23 marcadores microsatélites, de los cuales,        17 resultaron polimórficos. Se observaron 75 fragmentos polimórficos  amplificados, con un promedio de 4,41 alelos por locus y un rango de 1 a 9  alelos. El contenido de información polimórfica osciló entre 0,15 y 0,58. El  valor de        la diversidad genética promedio fue de 0,165. Tanto el análisis de  conglomerados como el de coordenadas principales evidenciaron dos grupos, uno  formado por los materiales representantes de la subespecie fastigiata        y otro por los de la subespecie hypogaea.  Los resultados del análisis molecular de la varianza  mostraron varianza tanto dentro como entre, las subespecies analizadas.","palabras_clave":"maní cultivado|Diversidad Genética|Microsatelites|germoplasma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39021,"idioma_id":4,"titulo":"The interplay of seven sub-threshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons","resumen":"The signaling properties of thalamocortical (TC) neurons depend on the diversity of ion conductance mechanisms that underlie their rich membrane behavior at sub-threshold potentials. Using patch clamp recordings of TC neurons in brain slices from mice and a realistic conductance-based computational model, we characterized seven sub-threshold ion currents of TC neurons and quantify their individual contribution to the total steady-state conductance at levels below tonic firing threshold. We then used the TC neuron model to show that the resting membrane potential results from the interplay of several inward and outward currents over a background provided by the potassium and sodium leak currents. The steady-state conductances of depolarizing Ih, IT and INaP move the membrane potential away from the reversal potential of the leak conductances. This depolarization is counteracted in turn by the hyperpolarizing steady state current of IA and IKir. Using the computational model, we show that single parameter variations compatible with physiological or pathological modulation, promote burst firing periodicity. The balance between three amplifying variables (activation of IT, activation of INaP and activation of IKir) and three recovering variables (inactivation of IT, activation of IA and activation of Ih) determine the propensity -or lack thereof- of repetitive burst firing of TC neurons. We also determined the specific roles that each of these variables have during the intrinsic oscillation.","palabras_clave":"Repetitive burst firing|Resting membrane potential|Sub-threshold conductances|Thalamocortical neuron"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39022,"idioma_id":5,"titulo":"Contribuciones y limitaciones del Plan FinEs 2 Secundaria. Perspectivas de estudiantes y profesores","resumen":"El artículo refiere a la Educación de Jóvenes y Adultos. En base a una investigación en marcha, aborda, de manera preliminar, las significaciones que docentes y estudiantes del Plan FinEs 2 Secundaria en la Provincia de Buenos Aires construyen acerca de las contribuciones que éste realiza a la efectivización de la igualdad educativa y al cumplimiento de la obligatoriedad del nivel secundario, así como de aquellas condiciones de su implementación que limitarían el logro de estos propósitos.","palabras_clave":"Educación de Jóvenes y Adultos|Docentes y estudiantes|Plan de terminalidad educativa"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39023,"idioma_id":4,"titulo":"Design of a phase-shifting interferometer in the extreme ultraviolet for high-precision metrology","resumen":"The design of a phase shift interferometer in the extreme ultraviolet (EUV) is described. The interferometer is expected to achieve a signi&#64257;cant higher precision as compared with similar instruments that utilize lasers in the visible range. The interferometer design is speci&#64257;cally adapted for its utilization with a table top pulsed capillary discharge extreme ultraviolet laser. The numerical model evaluates the errors in the interferograms and in the retrieved wavefront induced by the shot-to-shot &#64258;uctuations and pointing instabilities of the laser.","palabras_clave":"PHASE SHIFT|UV, EUV, AND X-RAY LASERS;|INTERFEROMETRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39024,"idioma_id":5,"titulo":"La formación inicial y continua de los docentes en los países de MERCOSUR. Problemas comunes, estructuras y desarrollos diversos","resumen":"A pesar de haber sido objeto de cambios y transformaciones recientes, las estructuras, planes y normas que organizan los sistemas de formación docente inicial y continua en los países del MERCOSUR, siguen en debate. En este contexto se plantea el desafío de encontrar puntos de articulación que contribuyan a la integración regional de los países del bloque y a la movilidad de los docentes.  Si bien los currículum y programas de formación continua constituyen solo una parte o dimensión del complejo proceso de la formación docente, su análisis y comparación resulta relevante y oportuna toda vez que se pretende mejorar la preparación de los maestros y profesores. En este marco, cabe interrogarse cuáles son las principales tendencias que caracterizan a las propuestas de formación en la región.El artículo resume los principales resultados alcanzados a través de un estudio llevado a cabo a solicitud del Programa de Apoyo al Sector Educativo del Mercosur (PASEM), cuyo propósito fue comparar los planes de formación docente inicial, así como la oferta y organización de la formación continua existente en los países miembro - fundadores del MERCOSUR: Argentina, Brasil, Uruguay y Paraguay. La metodología seguida focalizó en el relevamiento y análisis comparado de los documentos, lineamientos y programas de formación inicial y continua. Se trabajó en base a una serie de problemas, dimensiones y categorías de análisis con la intención de destacar aspectos compatibles y otros singulares que sean significativos tanto a los fines de la integración, como del mejoramiento de la formación docente.","palabras_clave":"FORMACIÓN|DOCENTES|PROGRAMA|PERFECCIONAMIENTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39025,"idioma_id":4,"titulo":"Variation of grazing-induced vegetation changes across a large-scale productivity gradient","resumen":"Questions  Does the magnitude of grazing-induced changes in species composition vary with habitat productivity? How does the sign and magnitude of grazing effects on species richness and beta-diversity change with increasing productivity? Do major life forms exhibit consistent responses to grazing along productivity gradients?    Location  Steppes and grasslands of southern South America in Argentina and Uruguay.    Methods  We evaluated grazing effects on plant composition, species richness, beta-diversity and life-form abundances along a ten-fold, regional productivity gradient and within subregions of contrasting productivity, using a common sampling protocol for 23 paired grazed vs ungrazed plots. The annual integral of the normalized difference vegetation index was used as a surrogate for above-ground net primary productivity.    Results  Compositional dissimilarity between grazed and ungrazed plots, as well as grazing-induced differences in plant richness and beta-diversity all increased with habitat productivity. Grazing decreased species richness in low-productive steppes but enhanced the richness of high-productive grasslands. On average, grazing reduced beta-diversity in high-productive sites but not in low-productive sites. Dominant species were more strongly suppressed by grazing towards productive grasslands. Grazing generally decreased shrub species cover, whereas graminoid and forb cover did not consistently change with grazing through the productivity gradient.    Conclusions  Our results indicate that the overall grazing effects on vegetation structure increased along a regional productivity gradient. Yet the sign of grazing impacts on species richness and beta-diversity shifted with habitat productivity, in agreement with models of herbivore-mediated co-existence and species colonization in productive systems. Further, we found that narrowing the spatial extent of analysis to the subregion generally obscured grazing?productivity relationships. Biodiversity conservation programmes should carefully weigh the varied impacts of livestock grazing across productivity gradients.","palabras_clave":"BETA DIVERSITY|DISSIMILARITY|NORMALIZED DIFFERENCE INDEX|PATAGONIAN STEPPE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39026,"idioma_id":5,"titulo":"Los saberes docentes en la mira: una aproximación polifónica","resumen":"Preguntarse acerca de lo que maestros y profesores tiene que saber para poder enseñar hoy, adquiere sentido en el marco de las transformaciones que atraviesan los sistemas educativos y el oficio docente. Este trabajo intenta brindar algunas respuestas a partir de los resultados obtenidos en una serie de investigaciones destinada al estudio del ?saber de la experiencia?; aquel que los docentes producen en su actividad cotidiana. Para analizar esta problemática se ha acudido a una polifonía de voces que reúne a los especialistas, a los propios docentes y a los formadores. Si bien tanto unos como otros valoran los saberes específicos ligados a la dimensión ?clásica? del oficio, llama la atención el protagonismo que cobran los saberes vinculados con los contextos y los destinatarios de la acción pedagógica. Posicionados desde el puesto de trabajo, maestros y profesores valoran principalmente aquellos saberes que les permiten ?poder hacerlo?. Los formadores enfatizan la importancia de relacionar la teoría con la práctica profesional. A partir de estos planteos, alertamos sobre la necesidad de orientar la formación docente hacia la transmisión del oficio (docente) y nos interrogamos por el ?más allá? de la contextualidad, la situacionalidad y la subjetividad tan mentadas en estos tiempos.","palabras_clave":"SABERES|DOCENTES|ESPECIALISTAS|FORMADORES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39027,"idioma_id":4,"titulo":": Reliability and Validity of the Arabic Version of the Computerized Battery for Neuropsychological Evaluation of Children (BENCI)","resumen":"Batería de Evaluación Neuropsicológica Infantil (BENCI) is a computerized battery for the neuropsychological  evaluation of children. This battery has been used in different studies to evaluate  neuropsychological functions and neurodevelopment in children. The objective of this study is to  test the validity and reliability of the first Arabic version of the BENCI on an Arabic population where  neuropsychological tests are very scarce. We administrate the BENCI to 198 school-age children (98  boys and 100 girls) from Morocco. To examine the test retest reliability of the BENCI battery, we  administered the battery 2 times to 43 children (23 boys and 20 girls) with 15 days in between the preand  posttest. The results revealed good validity and reliability of the battery in Arabic children. Also,  the BENCI battery has demonstrated the capacity to differentiate between children by their age group.  This battery can be of great use to both the research and clinical areas of Arabic countries and\/or in  assistance to Arabic immigrants that live outside of their native country.","palabras_clave":"Arab children|Neuropsychological battery|Test-retest|Neurodevelopment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39028,"idioma_id":4,"titulo":"Behavior of two eco-compatible duplex systems used in the construction industry against corrosion","resumen":"Two types of coated steels are currently competing in the construction industry: the hot-dip galvanized steel (HDGS) and the 55%Al-Zn alloy coated steel (HDZAS). Both systems are typically coated by a chromate-based conversion film, which is dangerous for human health and environment. Furthermore, for aesthetics purposes and\/or to prolong their expected or planned service life, they are painted designing each paint system as a function of the service conditions to which they will be subject to. The present work reports on a comparative study of two duplex systems: steel\/metal coating\/organic coating. In both cases, the chromate-based pretreatment was replaced by another one that features &#61543;-mercaptopropyltrimethoxysilane (MTMO) as an active element. The organic coating used was a water-based polyurethane. Behavior of this paint against corrosion was assessed by exposing the samples in Salt Spray or Humidity Chambers, and monitoring its evolution by Electrochemical Impedance Spectroscopy, visual observation, Scanning Electron Microscopy and Energy Dispersive X-ray Analysis. The results revealed that: MTMO was suitable for promoting adhesion both in HDGS and HDZAS; in humidity chamber, both duplex systems provided good protection; the presence of corrosion products of the base steel and paint blistering was detected in the HDGS\/paint system seventy-two days after exposure; however, 150 days after that, none of these effects were observed in the HDZAS\/paint system; differences in behavior were significant in Salt spray chamber: speed of paint delamination from the mark done and the bulk of corrosion products generated was much higher in HDGS\/paint system than in HDZAS\/paint.","palabras_clave":"GALVANIZED|DÚPLEX|55%ALZN|SILANE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39029,"idioma_id":4,"titulo":"Quantitative Developmental Data in a Phylogenetic Framework","resumen":"Following the embryonic period of organogenesis, most development is allometric growth, which is thought to produce most of the evolutionary morphological divergence between related species. Bivariate or multivariate coefficients of allometry are used to describe quantitative developmental data and are comparable across taxa; as such, these coefficients are amenable to direct treatment in a phylogenetic framework. Mapping of actual allometric coefficients onto phylogenetic trees is supported on the basis of the evolving nature of growth programs and the type of character (continuous) that they represent. This procedure depicts evolutionary allometry accurately and allows for the generation of reliable reconstructions of ancestral allometry, as shown here with a previously published case study on rodent cranial ontogeny. Results reconstructed the signature allometric patterns of rodents to the root of the phylogeny, which could be traced back into a (minimum) Paleocene age. Both character and statistical dependence need to be addressed, so thisapproach can be integrated with phylogenetic comparative methods that deal with those issues. It is shown that, in this particular sample of rodents, common ancestry explains little allometric variation given the level of divergence present within, and convergence between, major rodent lineages. Furthermore, all that variation is independent of body mass. Thus, from an evolutionary perspective, allometry appears to have a strong functional and likely adaptive basis.","palabras_clave":"Allometry|delayed correlations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39030,"idioma_id":4,"titulo":"A Process To Treat High-Strength Brewery Wastewater via Ethanol Recovery and Vinasse Fermentation","resumen":"ABSTRACT                      Certain wastewaters from  breweries (purges from fermentation processes, discarded beer, etc.) can exhibit  a chemical oxygen demand (COD) as high as 170000 mg O2\/L, which is  due to the ethanol and carbohydrates remnants from the fermentation process. These  effluents can represent up to 3% of the volume of beer produced and must be  treated prior to their discharge into the environment, which is currently accomplished  in conventional treatment plants that typically have anaerobic reactors (e.g.,  upflow anaerobic sludge blanket, UASB) and use a follow-up aerobic treatment. In  this work, a process that distills ethanol contained in these effluents and  ferments vinasses to enhance the ethanol production was developed, and its  technical-economic feasibility was studied. The process allows the organic load  to be depleted by 88% at a rate that is 15 times faster than that of conventional  processes. In addition, a valuable product, i.e., ethanol, is produced. ","palabras_clave":"Wastewater Treatment|Breweries |Vinasses|Ethanol"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39031,"idioma_id":4,"titulo":"Assessment of the water self-purification capacity on a river affected by organic pollution: application of chemometrics in spatial and temporal variations","resumen":"Water pollution caused by organic matter is a major global problem which requires continuous evaluation. Multivariate statistical analysis was applied to assess spatial and temporal changes caused by natural and anthropogenic phenomena along Potrero de los Funes River. Cluster analysis (CA), principal component analysis (PCA) and analysis of variance (ANOVA) were applied to a data set collected throughout a period of 3 years (2010?2012), which monitored 22 physical, chemical and biological parameters. Content of dissolved oxygen in water and biochemical oxygen demand in a watercourse are indicators of pollution caused by organic matter. For this reason, the Streeter-Phelps model was used to evaluate the water self-purification capacity. Hierarchical cluster analysis grouped the sampling sites based on the similarity of water quality characteristics. PCA resulted in two latent factors explaining 75.2 and 17.6 % of the total variance in water quality data sets. Multidimensional ANOVA suggested that organic pollution is mainly due to domestic wastewater run-offs and anthropogenic influence as a consequence of increasing urbanization and tourist influx over the last years. Besides, Streeter-Phelps parameters showed a low reaeration capacity before dam with low concentration of dissolved oxygen. Furthermore, self-purification capacity loss was correlated with the decrease of the Benthic Index. This measurement suggested that biological samplings complement the physical-chemical analysis of water quality.","palabras_clave":"Water quality|Multivariate techniques|Self-purification capacity|Deficit oxygenmodel|Benthic macroinvertebrates|PCA|ANOVA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39032,"idioma_id":4,"titulo":"High-Pressure Torsion of Ti: Synchrotron Characterization of Phase Volume Fraction and Domain Sizes","resumen":"Rods of grade 2 Ti were processed by Equal-Channel Angular Pressing (ECAP) (&#966; =  120º at 573 K) employing 2, 4 and 6 passes. The same billets were further deformed by High-  Pressure Torsion (HPT) at room temperature, varying both the hydrostatic pressure (1 and 6  GPa) and the number of rotations (n = 1 and 5). The ECAP and HPT samples were studied by  synchrotron radiation at DESY-Petra III GEMS line. On the ECAP samples, textures were thus  determined while for both ECAP and HPT samples the measurements were further analyzed by  MAUD. Domain sizes and phase volume fractions were determined as a function of the radial  direction of the samples. Alpha and Omega phases were detected in different amounts  depending mostly on hydrostatic pressure and shear deformation. These transition phases can  be pressure-induced during HPT processing and the results of Vickers microhardness  measurements were related to the processing parameters and to the amounts of these phases.","palabras_clave":"Nanostructure|SPD|ECAP|&#969;-Ti"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39033,"idioma_id":4,"titulo":"Response to Long-Term NaHCO 3 -Derived Alkalinity in Model Lotus japonicus Ecotypes Gifu B-129 and Miyakojima MG-20: Transcriptomic Profiling and Physiological Characterization","resumen":"The current knowledge regarding transcriptomic changes induced by   alkalinity on plants is scarce and limited to studies where plants were   subjected to the alkaline salt for periods not longer than 48 h, so   there is no information available regarding the regulation of genes   involved in the generation of a new homeostatic cellular condition after   long-term alkaline stress. Lotus japonicus is a model legume broadly   used to study many important physiological processes including biotic   interactions and biotic and abiotic stresses. In the present study, we   characterized phenotipically the response to alkaline stress of the most   widely used L. japonicus ecotypes, Gifu B-129 and MG-20, and analyzed   global transcriptome of plants subjected to 10 mM NaHCO3 during 21 days,   by using the Affymetrix Lotus japonicus GeneChip®. Plant growth   assessment, gas exchange parameters, chlorophyll a fluorescence   transient (OJIP) analysis and metal accumulation supported the notion   that MG-20 plants displayed a higher tolerance level to alkaline stress   than Gifu B-129. Overall, 407 and 459 probe sets were regulated in MG-20   and Gifu B-129, respectively. The number of probe sets differentially   expressed in roots was higher than that of shoots, regardless the   ecotype. Gifu B-129 and MG-20 also differed in their regulation of genes   that could play important roles in the generation of a new Fe\/Zn   homeostatic cellular condition, synthesis of plant compounds involved in   stress response, protein-degradation, damage repair and root   senescence, as well as in glycolysis, gluconeogenesis and TCA. In   addition, there were differences between both ecotypes in the expression   patterns of putative transcription factors that could determine   distinct arrangements of flavonoid and isoflavonoid compounds. Our   results provided a set of selected, differentially expressed genes   deserving further investigation and suggested that the L. japonicus   ecotypes could constitute a useful model to search for common and   distinct tolerance mechanisms to long-term alkaline stress response in   plants.","palabras_clave":"Lotus japonicus|salt stress|alkaline|microarray"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39034,"idioma_id":4,"titulo":"Saline tidal flooding effects on Spartina densiflora plants from different positions of the salt marsh. Diversities and similarities on growth, anatomical and physiological responses","resumen":"Spartina densiflora is a halophytic grass present in many salt marsh ecosystems where it dominates throughout topographical stress-gradients. This work aimed at studying diversities and similarities in ecophysiological responses of S. densiflora plants from two contrasting positions in the salt marsh. We simulated a natural tide by exposing plants of S. densiflora from upland and lowland sites of a salt marsh to saline intermittent flooding (9 h day -1) during 60 days. Responses in plant growth, biomass allocation, anatomy, ion regulation, and photosynthetic performance were assessed. Saline intermittent flooding caused changes in anatomical and morphological traits of plants from both sites associated with increased root aerenchyma and decreased mass allocation to leaf blades in relation to leaf sheaths, concomitant with reductions of blade size and changes in blade shape. Similar negative effects of saline intermittent flooding were found on physiological traits related to photosynthetic functioning of plants from both sites, like decreases in chlorophyll fluorescence, quantum efficiency and &#948;13C. However, lowland plants presented unaffected leaf length, better ion regulation (higher Cl- exclusion, higher K+concentration, and lower Na+\/K+ratio), as well as later leaf senescence with respect to upland plants, when subjected to saline intermittent flooding. Accordingly, plant biomass production decreased by 15 % and 32 % for lowland and upland plants, respectively. These results indicate that plants of S. densiflora inhabiting in the lowland positions have a better acclimation capacity to the harsh environment imposed by the tide than plants from the upland. &nbsp;","palabras_clave":"ALLOCATION|ION REGULATION|LEAF GROWHT|SALINITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39035,"idioma_id":4,"titulo":"Lotus tenuis x L. corniculatus interspecific hybridization as a means to breed bloat-safe pastures and gain insight into the genetic control of proanthocyanidin biosynthesis in legumes","resumen":"Proanthocyanidins (PAs) are secondary metabolites that strongly affect plant quality traits. The concentration and the structure of these metabolites influence the palatability and nutritional value of forage legumes. Hence, modulating PAs in the leaves of forage legumes is of paramount relevance for forage breeders worldwide. The lack of genetic variation in the leaf PA trait within the most important forage species and the difficulties in engineering this pathway via the ectopic expression of regulatory genes, prompted us to pursue alternative strategies to enhance this trait in forage legumes of agronomic interest. The Lotus genus includes forage species which accumulate PAs in edible organs and can thus be used as potential donor parents in breeding programs. Results: We recovered a wild, diploid and PA-rich population of L. corniculatus and crossed with L. tenuis. The former grows in an alkaline-salty area in Spain while the latter is a diploid species, grown extensively in South American pastures, which does not accumulate PAs in the herbage. The resulting interspecific hybrids displayed several traits of outstanding agronomic relevance such as rhizome production, PA levels in edible tissues sufficient to prevent ruminal bloating (around 5 mg of PAs\/g DW), biomass production similar to the cultivated parent and potential for adaptability to marginal lands. We show that PA levels correlate with expression levels of the R2R3MYB transcription factor TT2 and, in turn, with those of the key structural genes of the epicatechin and catechin biosynthetic pathways leading to PA biosynthesis. Conclusions: The L. tenuis x L. corniculatus hybrids, reported herein, represent the first example of the introgression of the PA trait in forage legumes to levels known to provide nutritional and health benefits to ruminants. Apart from PAs, the hybrids have additional traits which may prove useful to breed forage legumes with increased persistence and adaptability to marginal conditions. Finally, our study suggests the hybrids and their progeny as an invaluable tool to gain a leap forward in our understanding of the genetic control of PA biosynthesis and tolerance to stresses in legumes.","palabras_clave":"INTERSPECIFIC HYBRIDIZATION|LOTUS|PROANTHOCYANIDINS (PAS)|TT2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39036,"idioma_id":4,"titulo":"Evaluation of anti-Listeria meat borne Lactobacillus for biofilm formation on selected abiotic surfaces","resumen":"The ability of meat borne anti-ListeriaLactobacillus to form biofilm under different in vitro conditionsand on abiotic surfaces was investigated. Biofilm formation by the adhesion topolyestyrene microtiter plates was determined, this being higher for L.curvatus CRL1532, CRL705 and L. sakei CRL1862. The physicochemicalproperties of cell surface showed arelatively hydrophilic nature and acidic character; L. sakei CRL1862exhibiting the strongest autoaggregation ability. The adhesion of lactobacillito stainless steel (SS) and polytetrafluoroethylene (PTFE) supports at 10 °Cwas found to be maximal for L. sakei CRL1862 on SS after 6 days. Whenbiofilm architecture was characterized by epifluorescence and SEM, L. sakeiCRL1862 homogeneously covered the SS surface while cell clusters were observedon PTFE; extracellular polymeric substances matrix adapted to the topographyand hydrophilic\/hydrophobic characteristics of each material. The feasibilityof L. sakei CRL1862 to form biofilm on materials used in meat processinghighlights its potential as a control strategy for Listeria monocytogenesbiofilms.","palabras_clave":"ADHESION|MEAT BORNE LACTOBACILLI|ANTI-LISTERIA ACTIVITY|SURFACE PROPERTIES|STAINLESS STEEL|POLYTETRAFLUOROETHYLENE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39037,"idioma_id":4,"titulo":"Sliding Mode Control for Trajectory Tracking of a Non-holonomic Mobile Robot  using Adaptive Neural Networks","resumen":"In this work a sliding mode control method for a nonholonomic mobile robot using adaptive neural network is proposed. Due to this property and restricted mobility, the trajectory tracking of this system has been one of the research topics for the last ten years. The proposed control structure&nbsp;combines a feedback linearization model, based on a kinematics nominal model, and a practical design that combines an indirect neural adaptation technique with sliding mode control to compensate the dynamics of the robot. A neural sliding mode controller is used to approximate the equivalent control in the neighborhood of the sliding manifold, using an on-line adaptation scheme. A slinding control is appended to ensure that the neural sliding mode control can achieve a stable closed loop system for the trajectory tracking control of a mobile robot with unknown nonlinear dynamics. Also, the proposed control technique can reduce the steady state error using the online adaptive neural network with sliding mode control; the design is based on Lyapunov´s theory. Experimental results show that the proposed method is effective in controlling mobile robots with dynamic large uncertainties.","palabras_clave":"MOBILE ROBOTS|NONLINEAR SYSTEM|ADAPTIVE NEURAL CONTROL|SLIDING MODE CONTROL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39038,"idioma_id":4,"titulo":"Distribution of genetic polymorphisms associated to Hepatitis C virus (HCV) antiviral response in a multiethnic and admixed population","resumen":"Single-nucleotide polymorphisms (SNPs) near IL28B andITPA genes have been described as predictors of responseto antiviral treatment and ribavirin induced-hemolytic anemiain HCV patients, respectively. The prevalence of thesepolymorphisms differs among ethnic groups; however,there is a paucity of information about South Americanpopulations. Hence, the aim of this study was to determinethe prevalence of these SNPs in the healthy population ofdifferent ethnic groups residing in Argentina.DNA samples were obtained from 1287 unrelated anti-HCV [] volunteers and grouped as follows: i) Argentines(n = 951) born in the Pampean region; and ii) immigrants(n = 336) from other Latin American countries (178 Bolivians;88 Paraguayans and 70 Peruvians). SNPsrs1127354C&gt;A (ITPA) and rs12979860C&gt;T (IL28B) werePCR-amplified and characterized by nucleotide sequences.Ethnicity was assessed by analysis of Native American mitochondrialDNA and Y-SNPs (maternal and paternal haplogroups,respectively) using Real Time PCR followed by HighResolution Melting. Fisher?s exact test was used for statisticalanalysis. A p value &lt; 0.05 was considered as statisticallysignificant. In regard to IL28B (rs12979860C&gt;T) polymorphism,CC genotype -related to favorable treatmentresponse- was observed in 51.9% of Argentines versus35.9% of Bolivians (p &lt; 0.0001), 37.1% of Peruvians(p &lt; 0.05) and 39.8% of Paraguayans (p &lt; 0.05). In regardto ITPA (rs1127354C&gt;A) polymorphisms, CC genotype-related to higher risk of ribavirin induced-hemolytic anemia-was observed in 84.5% of Argentines versus 98.9% ofBolivians (p &lt; 0.0001), 95.7% of Peruvians (p &lt; 0.01) and93.2% of Paraguayans (p &lt; 0.01). As regards ancestry,42.7% of Argentines, 94.6% of Bolivians, 94% of Peruviansand 98% of Paraguayans showed Native American maternallineages (p &lt; 0.0001); whereas, 1% of Argentines, 71%of Bolivians, 40% of Peruvians and 17.9% of Paraguayansshowed Native American paternal haplogroups (p &lt; 0.002).This is the first systematic study of polymorphismsrelated to antiviral response in HCV infection and ethnicitycharacterization in the South American population. Thereis a significant bias in the distribution of predictive polymorphismsof response to HCV treatment according to thepopulation ancestry. This study highlights the importanceof the previous characterization of these variants to evaluatethe risk-benefit of antiviral treatment according to thepatient ancestry, particularly in a multiethnic and admixedpopulation","palabras_clave":"HCV|IL28B|ITPA|ETHNIC GROUPS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39039,"idioma_id":4,"titulo":"Validation of a continuous flow method for the determination of soluble iron in atmospheric dust and volcanic ash","resumen":"Iron is an essential micronutrient for phytoplankton growth and is supplied to the remote areas of the ocean mainly through atmospheric dust\/ash. The amount of soluble Fe in dust\/ash is a major source of uncertainty in modeling-Fe dissolution and deposition to the surface ocean. Currently in the literature, there exist almost as many different methods to estimate fractional solubility as researchers in the field, making it difficult to compare results between research groups. Also, an  important constraint to evaluate Fe solubility in atmospheric dust is the limited mass of sample which is usually only available in micrograms to milligrams amounts. A continuous flow (CF) method that can be run with low mass of sediments (<10 mg) was tested against a standard method which require about 1 g of sediments (BCR of the European Union). For validation of the CF experiment, we run both methods using South American surface sediment and deposited volcanic ash. Both materials tested are  easy eroded by wind and are representative of atmospheric dust\/ash exported from this region. The uncertainty of the CF method was obtained from seven replicates of one surface sediment sample, and shows very good reproducibility. The replication was conducted on different days in a span of two years and ranged between 8-22% (i.e., the uncertainty for the standard method was 6-19%). Compared to other standardized methods, the CF method allows studies of dissolution kinetic of metals and consumes less reagents and time (<3 hours). The method validated here is suggested to be used as a standardized method for Fe solubility studies on dust\/ash.","palabras_clave":"IRON SOLUBILITY|CONTINUOS FLOW|STANDARDIZATION|DUST|VOLCANIC ASH|IRON FERTILIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39040,"idioma_id":4,"titulo":"An innovative   micrometric  granular graphite?glass system composite electrode   ?ready  to   use?  in voltammetry techniques","resumen":"A low cost composite electrodes employing tellurite oxide, vanadium oxide and  micrometric granular graphite (NWE), were designed as an alternative to be used  as working electrode in voltammetry techniques. The synthesis of these composite  electrodes is carried out easily; in a short time and their surface not require  previous preparation. X-Ray diffraction, X-ray fluorescence spectrometry and  optical microscopy studies were used to determine the morphology and chemical  composition of these electrodes. The conductivity characterization was conducted  with impedance and electrochemical measurements. The electrochemical  Page 2 of 24  Accepted Manuscript  2  properties of NWE were studied using potassium hexacyanoferrate (II) and  ascorbic acid system.","palabras_clave":"GRAPHITE-GLASS SYSTEM|COMPOSITE ELECTRODE|LOW COST ELECTRODE FABRICATION|VOLTAMMETRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39041,"idioma_id":4,"titulo":"An ontology-based framework to support intelligent data analysis of sensor measurements","resumen":"In the past years, the large availability of sensed data highlighted the need of computer-aided systems that perform Intelligent Data Analysis (IDA) over the obtained data streams. Temporal Abstractions (TA) are key to interpret the principle encoded within the data, but their usefulness depends on an efficient management of domain knowledge.    In this article, an ontology-based framework for IDA is presented. It is based on a knowledge model composed by two existing ontologies (Semantic Sensor Network ontology (SSN), SWRL Temporal Ontology (SWRLTO)) and a new developed one: the Temporal Abstractions Ontology (TAO).  SSN conceptualizes sensor measurements, thus enabling a full integration with Semantic Sensor Web (SSW) technologies. SWRLTO provides temporal modeling and reasoning. TAO has been designed to capture the semantic of TAs. These ontologies have been aligned through DOLCE Ultra-Lite (DUL) upper ontology, boosting the integration with other domains.   The resulting knowledge model has a modular design that facilitates the integration, exchange and reuse of its constitutive parts.   The framework is sketched in a chemical plant case study. It is shown how complex temporal patterns that combine several variables and representation schemes can be used to infer process states and\/or conditions.","palabras_clave":"INTELLIGENT DATA ANALYSIS |TEMPORAL ABSTRACTION |TEMPORAL REASONING |ONTOLOGY |SEMANTIC SENSOR WEB"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39042,"idioma_id":4,"titulo":"Reproductive biology of the Amazon Lava Lizard (Tropidurus torquatus) from the Wet Chaco of Corrientes (Argentina): congeneric comparisons of ecotypic and interspecific variations","resumen":"    Herein we describe  the reproductive biology of a population of Tropidurus  torquatus (Wied-Neuwied, 1820) from  Corrientes, northeastern Argentina (Wet Chaco). We describe the male and female reproductive cycles,  minimum body size for adults, reproductive output, mean relative clutch mass,  fat body cycles, and sexual dimorphism. Our results were compared with data on  the reproductive biology of Brazilian populations of T. torquatus and congeneric species. In Corrientes, males of T. torquatus exhibited a continuous  reproductive cycle, but with annual variation of testicular parameters associated  to spermatogenic activity. In contrast, females were reproductive only from  winter to summer (July-February), laying at least two clutches each of six eggs  on average per reproductive season. The relative clutch mass and egg size  values in Corrientes were the highest reported for the species. The annual  cycle of energy storage (as fat bodies) was inversely correlated with  reproductive activity in both sexes. Males differed from females in snout-vent length,  head size, interlimb length, and tail length. We observed interpopulational differences  in relative clutch mass, egg volume and mass, incubation period and hatching  time, and the minimum body size for sexual maturity probably as a result of  phenotypic plasticity or adaptation to local environmental conditions and  likely both.  ","palabras_clave":"REPRODUCTIVE CYCLE|SQUAMATA|TROPIDURID|LIZARD|TROPIDURUS TORQUATUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39043,"idioma_id":4,"titulo":"Global conservation outcomes depend on marine protected areas with five key features","resumen":"In line with global targets agreed under the Convention on Biological  Diversity, the number of marine protected areas (MPAs) is increasing  rapidly, yet socio-economic benefits generated byMPAsremain  difficult to predict and under debate1,2.MPAs often fail to reach their  full potential as a consequence of factors such as illegal harvesting,  regulations that legally allow detrimental harvesting, or emigration  of animals outside boundaries because of continuous habitat or  inadequate size of reserve3?5. Here we show that the conservation  benefits of 87 MPAs investigated worldwide increase exponentially  with the accumulation of five key features: no take, well enforced,  old (.10 years), large (.100km2), and isolated by deep water or sand.  Using effective MPAs with four or five key features as an unfished  standard, comparisons of underwater survey data from effectiveMPAs  with predictions based on survey data from fished coasts indicate  that total fish biomass has declined about two-thirds fromhistorical  baselines as a result of fishing. Effective MPAs also had twice asmany  large (.250mmtotal length) fish species per transect, five timesmore  large fish biomass, and fourteen times more shark biomass than  fished areas. Most (59%) of the MPAs studied had only one or two  key features and were not ecologically distinguishable from fished  sites. Our results show that global conservation targets based on  area alone will not optimize protection ofmarine biodiversity.More  emphasis is needed on better MPA design, durable management  andcompliance to ensure thatMPAs achieve their desired conservation  value.","palabras_clave":"MARINE PROTECTED AREAS|REEF FISHES|GLOBAL SCALE|OUTCOMES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39044,"idioma_id":4,"titulo":"Composite Resins Based on Novel and Highly Reactive Bisglycidyl Methacrylate Monomers","resumen":"Three new bisglycidyl monomers; 1,4-bis((2-hydroxy-3-methacryloxypropoxy) methyl)benzene (MB-Phe-OH), 1,4-bis(2-hydroxy-3-methacryloxypropoxy)2-cis-butene (MB-Cis-OH), and 1,7-bis(2-hydroxy-3-methacryloxypropoxy)heptane (MB-1,7-OH);were synthesized and used as Bis-GMA\/TEGDMA (bisphenolglycidyl methacrylate\/triethylene glycol dimethacrylate) composite resinadditives. Flexural properties and double bond conversion of the dental resins composed of silanizated inorganic filler and organicmatrices containing new monomers were evaluated. The composite resins formulated, using the monomers MB-Cis-OH and MB-1,7-OH, have mechanical properties and double bond conversion comparable with those of Bis-GMA\/TEGDMA composite resin used ascontrol. The composite containing the new monomer MB-Phe-OH has better flexural properties (flexural strength 65.01 MPa andflexural modulus 5675.91 MPa) than the control composite resin (flexural strength 52.85 MPa and flexural modulus 4879.72 MPa);this could be attributed to the molecular structure of the monomer and its high double bond conversion level of 74.19%. The newbisglycidyl methacrylate monomer MB-Phe-OH could be potentially useful in the development of new organic matrices for dentalcomposite resins with high double bond conversion and enhanced mechanical properties. VC 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2014, 131, 40971.","palabras_clave":"BIOMATERIALS|COMOPOSITES|CROSSLINKING|PHOTOPOLYMERIZATION|RESINS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39045,"idioma_id":4,"titulo":"Development of PtGe and PtIn anodic catalysts supported on carbonaceous materials for DMFC","resumen":"Bimetallic PtGe and PtIn catalysts (Ge\/Pt and In\/Pt molar ratios = 0.33, 17 wt% Pt loading) were prepared over carbonaceous supports (carbon Vulcan, carbon nanotubes and structured mesoporous carbon). The liquid phase deposition-reduction method by using 0.4 M sodium borohydride as a reducing agent was employed. The electrocatalytic activity for methanol oxidation was compared with a commercial Pt\/CV E-TEK catalyst. The onset potential of the CO oxidation was shifted to less positive values for carbon Vulcan and carbon nanotubes supported catalysts and with a smaller effect in the case of mesoporous carbon supported ones. The best electrocatalytic performance was obtained by using carbon Vulcan as support of bimetallic catalysts, followed by carbon nanotubes. The performance of mesoporous carbon as a support was not adequate. PtGe\/CV, PtGe\/NT and PtIn\/CV catalysts displayed the best performance in DMFC. The good performance of these catalysts could be due to the presence of small particle sizes with a narrow distribution, and to geometric effects (observed from different characterization techniques) related to a probable decoration of Ge or In around the small Pt particles.                       ","palabras_clave":"electrocatalizadores bimetálicos|PtGe y PtIn"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39046,"idioma_id":4,"titulo":"Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection","resumen":"This study examined the immunogenic properties of the fusion protein fimbria 2 of Bordetella pertussis (Fim2)?cholera toxin B  subunit (CTB) in the intranasal murine model of infection. To this end B. pertussis Fim2 coding sequence was cloned downstream  of the cholera toxin B subunit coding sequence.Theexpression and assembly of the fusion protein into pentameric structures (CTBFim2)  were evaluated by SDS-PAGE and monosialotetrahexosylgaglioside (GM1-ganglioside) enzyme-linked immunosorbent  assay (ELISA). To evaluate the protective capacity of CTB-Fim2, an intraperitoneal or intranasal mouse immunization schedule  was performed with 50 &#120583;g of CTB-Fim2. Recombinant (rFim2) or purified (BpFim2) Fim2, CTB, and phosphate-buffered saline  (PBS) were used as controls. The results showed that mice immunized with BpFim2 or CTB-Fim2 intraperitoneally or intranasally  presented a significant reduction in bacterial lung counts compared to control groups (&#119875; < 0.01 or &#119875; < 0.001, resp.). Moreover,  intranasal immunization with CTB-Fim2 induced significant levels of Fim2-specific IgG in serum and bronchoalveolar lavage  (BAL) and Fim2-specific IgA in BAL. Analysis of IgG isotypes and cytokines mRNA levels showed that CTB-Fim2 results in a  mixed Th1\/Th2 (T-helper) response. The data presented here provide support for CTB-Fim2 as a promising recombinant antigen  against Bordetella pertussis infection.","palabras_clave":"CTB|Fimbria 2|Protección|Pertussis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39047,"idioma_id":4,"titulo":"Cytokine Production but Lack of Proliferation in Peripheral Blood Mononuclear Cells from Chronic Chagas Disease Cardiomyopathy Patients in Response to T. cruzi Ribosomal P Proteins","resumen":"Background: Trypanosoma cruzi ribosomal P proteins, P2beta and P0, induce high levels of antibodies in patients with chronic Chagas disease Cardiomyopathy (CCC). It is well known that these antibodies alter the beating rate of cardiomyocytes and provoke apoptosis by their interaction with beta1-adrenergic and M2-muscarinic cardiac receptors. Based on these findings, we decided to study the cellular immune response to these proteins in CCC patients compared to non-infected individuals.  Methology\/Principal findings: We evaluated proliferation, presence of surface activation markers and cytokine production in peripheral blood mononuclear cells (PBMC) stimulated with P2beta, the C-terminal portion of P0 (CP0) proteins and T. cruzi lysate from CCC patients predominantly infected with TcVI lineage. PBMC from CCC patients cultured with P2beta or CP0 proteins, failed to proliferate and express CD25 and HLA-DR on T cell populations. However, multiplex cytokine assays showed that these antigens triggered higher secretion of IL-10, TNF-alpha and GM-CSF by PBMC as well as both CD4+ and CD8+ T cells subsets of CCC subjects. Upon T. cruzi lysate stimulation, PBMC from CCC patients not only proliferated but also became activated within the context of Th1 response. Interestingly, T. cruzi lysate was also able to induce the secretion of GM-CSF by CD4+ or CD8+ T cells.   Conclusions\/Significance: Our results showed that although the lack of PBMC proliferation in CCC patients in response to ribosomal P proteins, the detection of IL-10, TNF-alpha and GM-CSF suggests that specific T cells could have both immunoregulatory and pro-inflammatory potential, which might modulate the immune response in Chagas disease. Furthermore, it was possible to demonstrate for the first time that GM-CSF was produced by PBMC of CCC patients in response not only to recombinant ribosomal P proteins but also to parasite lysate, suggesting the value of this cytokine to evaluate T cells responses in T. cruzi infection  &#8195;","palabras_clave":"CARDIOMYOPATHY|CRORR-REACTION|CYTOKINES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39048,"idioma_id":4,"titulo":"Does inundation risk affect leaf-cutting ant distribution? A study along a topographic gradient of a Costa Rican tropical wet forest","resumen":"Successional state of forest and availability of pioneer plants are recognized factors affecting densities ofleaf-cutting ants. However little is known about how abiotic factors can shape nest distributions. We investigated theeffect of topography, soil, forest successional state and inundation risk on nest density and size of Atta cephalotes coloniesalong streams in a tropical wet forest in Costa Rica. In each forest type, we surveyed 12 sites, each site comprising&#64257;ve transects (10 × 100 m) varying in topography and proximity to streambeds. We found no difference regardingnest size or density between forest types or soil consociation. Nest density varied with topographic environment, withsigni&#64257;cantly higher nest density on slope tops (farther from streambeds) and without colonies in valley bottoms (closerto streambeds). Nests found in areas affected by the last great inundation before our study were scarcer and smallerthan nests in non-&#64258;ooded areas. We showed that inundation events favour an accumulation of Atta colonies towardshigher sites, where they are also allowed to become larger and may survive longer. Inundation risk may be a strongforce shaping the distribution of leaf-cutting ant nests in tropical &#64258;oodplain forests, even concealing the relevance ofsuccessional state of forest.","palabras_clave":"ant abundance|ant nests|disturbance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39049,"idioma_id":4,"titulo":"Nocturnal resource defence in aphid-tending ants of northern Patagonia","resumen":"1.  Interspeci&#64257;c  competition  plays  a  key  role  in  the  organisation  of  antcommunities. In ant?plant interactions, individual host plants are usually occupiedby a single ant colony, and co-occurring ant species compete for hosts. Here indirectevidence of competition between three dominant ant species that tend aphids on twobiennial thistles in northern Patagonia is described, and a novel defensive behaviourin temperate ant assemblages is reported.2. This study has found that: (i) dominant ant species were not spatially segregated,thus enhancing the probability of &#64257;ghts and invasions of host plants; (ii) ant speciesdid  not  show  preferences  for  a  thistle  species  or  for  any  plant  characteristic,  andthus all plants have similar chances of being colonised by all dominant ant species;(iii) the resident ant species remained on the same plant during the whole plant lifecycle, monopolising plant resources (aphids); and (iv) all dominant species, whosenests  are  on  the  ground,  assigned  some  ants  to  stay  on  the  host  plant  during  thenight, when the low temperatures typical of this temperate environment greatly reduceforaging activities. When these ?nocturnal guards? were experimentally removed fromthe host plant, other ants from the same colony rapidly appeared showing aggressivebehaviours.3. Taking all these &#64257;ndings together, it is suggested that interspeci&#64257;c competitionin&#64258;uences the distribution of ants on their host plants and involves nocturnal defensivebehaviours  despite  unfavourable  thermal  conditions.  This  illustrates  how  habitatfeatures, such as the short life cycle of thistles and the low night-time temperaturesthat  reduce  ant  foraging  and  thus  make  plants  more  vulnerable  to  invasion,  mightaffect the distribution and behaviour of ants.","palabras_clave":"Ant communities|aphids|competition"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39050,"idioma_id":5,"titulo":"Factores que influyen sobre la actividad microbiana en basureros de hormigas cortadoras de hojas","resumen":"Los  microorganismos  del  suelo  cumplen  un  papel  relevante  en  el  ciclado  de  nutrientes.  En consecuencia,  conocer  los  factores  que  influyen  sobre  su  actividad  es  de  fundamental  importancia  para comprender mejor el funcionamiento de los ecosistemas terrestres. Empleando a los basureros externos de la hormiga cortadora Acromyrmex lobicornis como sistema modelo, analizamos la asociación de la diversidad de compuestos carbonados y la concentración de carbono con la respiración potencial de microorganismos en ese sustrato. En muestras de basureros en condiciones controladas de laboratorio estimamos la concentración de carbono y la respiración de los microorganismos. En paralelo, cuantificamos la diversidad de la dieta de cada nido como un estimador de la diversidad de compuestos carbonados en sus basureros. La actividad de los microorganismos no se relacionó con la concentración de carbono en los basureros pero mostró una relación de tendencia positiva con la riqueza de la dieta de las hormigas. Como la diversidad de compuestos carbonados en el basurero podría reflejar parcialmente la diversidad de plantas cosechadas por las hormigas, este resultado sugiere que la actividad de los microorganismos descomponedores depende parcialmente de la diversidad de recursos para descomponer. Este trabajo ejemplifica cómo las hormigas cortadoras afectan al suelo en ambientes áridos en donde la materia orgánica es limitante; e ilustra de forma novedosa cómo la pérdida de la diversidad vegetal, al empobrecer la dieta de las hormigas, puede afectar indirecta y negativamente la actividad de los descomponedores.","palabras_clave":"Acromyrmex lobicornis|decomposition|diversity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39051,"idioma_id":4,"titulo":"Moisture enhances the positive effect of leaf-cutting ant refuse dumps on soil biota activity","resumen":"Soil biota activity in arid lands is often limited by the availability   of water and organic matter. We experimentally explored whether small   changes in soil moisture affect the activity of soil biota in external   refuse dumps of the leaf-cutting ant Acromyrmex lobicornis, one of the most important sources of organic matter in a semi-arid land of north-western Patagonia. We estimated CO2   consumption in refuse dumps and in adjacent, non-nest soil samples at   two moisture levels, after 48 and 72&#8201;h. Soil biota activity, estimated   by respiration rates, was up to 160 times greater in refuse dumps than   in adjacent, non-nest soils. Activity of soil biota in non-nest soil did   not change through time and was not affected by moisture. Conversely,   soil biota increased their activity in refuse dump samples only at high   moisture condition after 72&#8201;h. As the activity of microorganisms is key   for soil nutrient generation and availability, refuse dumps may be   considered as ?islands of fertility? for plants. This effect may be   especially important after sporadic spring rainfalls, when the   beneficial effect of refuse dumps on soil biota is enhanced. In   addition, as refuse dumps generate several times more CO2 than non-nest soils, nest areas may be considered also as hot spots of CO2   emissions. These results illustrate the potential importance of ant   nests for nutrient cycling, maintenance of plant cover and carbon   balance in arid ecosystems.","palabras_clave":"Acromyrmex lobicornis|ANT DEBRIS|ARID ECOSYSTEM|PATAGONIA|SOIL FERTILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39052,"idioma_id":4,"titulo":"Linkages between the southern Patagonia Pre-Permian basements: new insights from detrital zircons U-Pb SHRIMP ages from the Cerro Negro District","resumen":"The Patagonian basement rocks are dominated by Precambrian to Early Paleozoic metamorphic rocks intruded by Paleozoic granitoids. Recently discovered basement rocks in the Cerro Negro District are characterized mainly by quartz-muscovite-chlorite schists; the metamorphic grade reaches greenschist facies (biotite-garnet grade) with a regional S1 schistosity subparallel to the original sedimentary structure S0 and a secondary nonpenetrative S2 foliation. New detrital zircon U-Pb geochronology shows that maximum depositional ages for detrital zircons are Devonian, ages of 379 ± 4Ma. These results suggest that the Cerro Negro basement rocks are the youngest basement in the Deseado Massif, overlapping some detrital zircon ages in the eastern Andean Metamorphic Complex in the Andean region. Most of detrital zircons are igneous in origin with a major peak around ~396Ma, provably sourced from the Devonian granitoids of the Río Deseado Complex (El Laurel and Bahía Laura granites) and equivalent northern Patagonia granitoids (e.g. Colan Conhué and Lago Lolog granites). Secondary peaks correspond to Ordovician to Silurian ages, being the Río Deseado Complex and La Modesta Formation (and their igneous contributors) the possible sources of the zircons. The minor oldest peaksyield Cambrian-Neoproterozoic; Mesoproterozoic and Paleoproterozoic-Archean ages, evidencing a common source from the interior of Gondwana. The results provide new insights about the relationships between the pre-Permian metasedimentary rocks of the extra-Andean and Andean region during Mid-Paleozoic ages.","palabras_clave":"PATAGONIA|DESEADO MASSIF|BASEMENT|U-PB SHRIMP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39054,"idioma_id":4,"titulo":"Spontaneous formation of metallic nanostructures on highly oriented pyrolytic graphite (HOPG): an ab initio and experimental study","resumen":"  \t\t\t    \t\t\t\t    \t\t\t\t\t    \t\t\t\t\t\t  We have investigated the decoration of step-edges of HOPG by Ag, Au and Pt using  experimental and theoretical approaches. Metallic nanowires can be formed on bare or  functionalized step-edges. Energy dispersion analysis indicates the presence of  oxygenated groups. The experiments showed that nanowires can be obtained with the  three metals along the step-edges, but the shapes and morphologies are very different.  We have found that the interaction between the metal wires and the carbon follows the  sequence: Pt &gt; Au &gt; Ag. The electronic redistribution between the atoms participating  in the bond between the metallic nanowire and the step-edges shows a complicated  pattern. The density of electronic states projected on the different atoms indicates that  there are different orbitals participating in the bonds.    \t\t\t\t\t  \t\t\t\t  \t\t\t  \t\t","palabras_clave":"AU AG Pt|NANOSTRUCTURES|DFT|HOPG"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39055,"idioma_id":4,"titulo":"An ethanol solvated centro symmetric dimer of bismuth(III) and thiosaccharinate resulting from semicoordination contacts","resumen":"In the title compound, bis(-1,1-dioxo-1,2-benzothiazole-3-thiolato)-3N,S:S;3S:N,S-bis[(1,1-dioxo-1,2-benzothiazole-3-thiolato-2N,S)(ethanol-O)bismuth(III)] ethanol hemisolvate,[Bi2(C7H4NO2S2)6(C2H5OH)2]0.5C2H5OH, three independentthiosaccharinate (tsac) anions chelate the metalcentre through the endocyclic N and exocyclic S atoms. Thecomplex also presnts two ?semicoordination? contacts, onefrom a pendant ethanol solvent molecule and a second onefrom an S atom of a centrosymmetrically related molecule.This latter interaction complements two ? interactionsbetween tsac rings to form a dimeric entity which is theelemental unit that builds up the crystal structure. Thesedinuclear units are connected to each other via a second typeof ? interaction, generating chains along [111]. Two ethanolmolecules, one of them of full occupancy at a general positionand semicoordinated to the central cation, and a second onedepleted and disordered around a symmetry centre, stabilizethe structure. The complex was studied theoretically and thevibrational assignations were confirmed by employing theoreticaldensity functional theory (DFT) methods.","palabras_clave":"Bismuth|Thiosaccarinate"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39056,"idioma_id":4,"titulo":"Thickness determination of electrochemical titanium oxide (Ti\/TiO2) formed in HClO4 solutions","resumen":"Anodic Titanium oxide films were potentiodinamically grown on Ti foil and glass\/Ti in 0.010 M HClO4 at 50 mVs-1 . The current density-potential curves (j vs.E) showed that the oxide grows according to the physical model for high-field conduction. However, for final potential (Ef) higher than 1.5 V vs. Ag\/AgCl (sat. KCl) the oxygen evolution reaction becomes more significant, and the formation of bubbles prevented or made more difficult the application of in situ techniques for the simultaneous study of the thickness and optical properties of the anodic layer. We developed a method based on electron probe microanalysis (EPMA) to calculate oxide thickness using ex situ ellipsometry as a reference technique. The normalized intensity of the OKa peaks was measured for anodic oxides corresponding to Ef values from spontaneous oxide up to 50 V, where a linear relationship was observed for a narrower range of final potentials. This behaviour was studied with Monte Carlo simulations. After calibration with ellipsometric results, to take into account sample damage during the electron irradiation, EPMA was applied as a method for thickness determination at Ef &gt; 1.0 V. Once the method was established, ex situ thickness determinations became independent of the preparation method of the oxide layer, which represents a comparative advantage against ex situ ellipsometry.","palabras_clave":"ELECTROCHEMISTRY|ELLIPSOMETRY|EPMA|OXIDE GROWTH|TIO2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39057,"idioma_id":4,"titulo":"Highly efficient removal of Cr(VI) from water with nanoparticulated zerovalent iron: understanding the Fe(III)-Cr(III) passive outer layer structure","resumen":"Nanoscale zerovalent iron (nZVI) particles were successfully employed for Cr(VI) removal from aqueous solutions at pH 3. It was found that the capacity of the system increases with increasing nZVI dosage. Starting at 300 microM, a complete Cr(VI) conversion was achieved in 30 min with a Fe:Cr(VI) molar ratio (MR) of 3, and 45% conversion with MR = 1 over the same period of time. The material exhibited an enhanced reactivity in comparison with other previously tested similar materials.   The proposed mechanism involves an initial reduction of Cr(VI) to Cr(III) by reaction with Fe0 or Fe(II) on the particle surface or in solution (secondary pathway), followed by an arrest on Cr(VI) removal attributed to the passivation of the surface of the nanoparticles. Passivation was confirmed by Raman and X-ray photoelectron spectroscopic (XPS). Furthermore, XPS analysis demonstrated that Cr(III) is the only Cr species present in the external layer of the nanoparticles after the reaction. Raman analysis and XPS measurements performed after mild sputtering showed that nZVI exposed to Cr(VI) presented a structure, from outside to inside, of hydroxychromites -> magnetite -> Fe0.","palabras_clave":"Hexavalent chromium|nanoscale zerovalent iron|XPS analysis|Raman spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39058,"idioma_id":4,"titulo":"Durable ethanol steam reforming in a catalytic membrane reactor at moderate temperature over cobalt hydrotalcite","resumen":"Se presenta en archivo pdf adjunto","palabras_clave":"REFORMING|ETHANOL|MEMBRANE|CATALYTIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39059,"idioma_id":4,"titulo":"A new species of Supramontana Carbayo & Leal-Zanchet (Platyhelminthes, Continenticola, Geoplanidae) from the Interior Atlantic Forest","resumen":"Supramontana argentina sp. nov. (Platyhelminthes, Continenticola, Geoplanidae) from north-eastern Argentina is herein described. The new species differs from Supramontana irritata Carbayo & Leal-Zanchet, 2003 from Brazil, the only species of this genus so far described, by external and internal morphological characters. Supramontana argentina sp. nov. is characterized by having a colour pattern with a yellowish median band, thin para-median black stripes, and two dark grey lateral bands on the dorsal surface. The most outstanding features of the internal morphology are a ventral cephalic retractor muscle almost circular in cross section, prostatic vesicle extrabulbar, tubular and very long, and penis papilla conical and blunt with a sinuous ejaculatory duct.","palabras_clave":"TRICLADS|LAND PLANARIAN|GEOPLANINAE|NEOTROPICAL REGION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39060,"idioma_id":4,"titulo":"Land planarian assemblages in protected areas of the Interior Atlantic Forest: implications for conservation","resumen":"Land planarians are an interesting group of free-living flatworms that can be useful as bioindicators because of their high sensitivity to environmental changes and low dispersal capacity. In this study, we describe and compare assemblages of land planarians from areas with different conservation degrees of the Interior Atlantic Forest (Misiones, Argentina), and assess factors that could be related to their abundance and richness. Eight sites were tracked in search of land planarians in  Reserva de Vida Silvestre Urugua-&#305;´ (RVSU) and Campo Anexo Manuel Belgrano (CAMB). Diurnal and nocturnal surveys were performed in each site along nine sampling campaigns. We collected 237 individuals belonging to 18 species of the subfamily Geoplaninae. All sites were dominated by Geoplana sp. 1 and Pasipha hauseri. The richness estimators showed that there would be more species in RVSU than in CAMB. The abundance and richness of land planarians was high during the night and after rainfalls, suggesting an increased activity of flatworms under such conditions. The abundance and richness of land planarians were also related to the conservation condition of the sites. Disturbed sites showed less abundance and richness, and were segregated from non-disturbed ones by nmMDS analysis. Beta diversity between sites was higher than expected, indicating that the species turnover between sites contributed more to the total richness (gamma diversity) than the alpha diversity.","palabras_clave":"LAND FLATWORMS|ATLANTIC FOREST|DIVERSITY|CONSERVATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39061,"idioma_id":4,"titulo":"The family Caecidae (Gastropoda: Caenogastropoda) in Argentine waters","resumen":"This is the first formal report of members of the family Caecidae in Argentine waters. Caecum striatum de Folin, 1868, C. strigosum de Folin, 1868, and C. achirona (de Folin, 1867) are re-described from shallow waters off Piedras Coloradas (40º53?4.83?? S, 65º7?34.53?? W), Río Negro Province, Argentina. This is the farthest south record of these species which were previously recorded from USA, Bahamas, Panama, Brazil, and Uruguay. The authors also make observations about the different ontogenetic stages of the studied species. Scanning electron microscope illustrations of radula and operculum are provided for the first time.","palabras_clave":"Caecidae|Mar Argentino|Argentine Sea"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39062,"idioma_id":4,"titulo":"Gender Influence on Schizophrenia-Relevant Abnormalities in a Cuprizone Demyelination Model","resumen":"The aim of this study was to determine whether early demyelination can impact behavior in young adulthood. For this purpose,  albino Wistar rats of either sex were exposed to cuprizone (CPZ) in two different intoxication protocols: one group was  intoxicated before weaning (CPZ-BW), from postnatal day 7 (P7) to P21, through maternal milk, whereas the other group was  intoxicated after weaning (CPZ-AW), from P21 to P35. After treatment, rats were returned to a normal diet until P90 when  behavioral studies were performed. Both treatments produced marked demyelination in the corpus callosum and retraction of  cortical myelin fibers. The subsequent normal diet allowed for effective remyelination at P90. Interestingly, CPZ-AW correlated  with significant behavioral and neurochemical changes in a gender-dependent manner. CPZ-AW treatment altered both  the number of social activities and the latency to the first social interaction in males, while also highly compromising  recognition-related activities. In addition, only P90 males treated AW showed a hyperdopaminergic striatum, confirmed by an  increase in tyrosine hydroxylase expression and in dopamine levels. Our results suggest that the timing of demyelination significantly  influences the development of altered behavior, particularly in adult males.","palabras_clave":"cuprizone|myelin impairment|behavioral changes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39063,"idioma_id":4,"titulo":"Daily rhythms of catalase and glutathione peroxidase expression and activity are endogenously driven in the hippocampus and are modified by a vitamin a-free diet","resumen":"Objectives. Alterations in enzymatic antioxidant defense systems lead to a deficit of cognitive functions and altered hippocampal synaptic plasticity. The objectives of this study were to investigate endogenous rhythms of catalase (CAT) and glutathione peroxidase (GPx) expression and activity, as well as CREB1 mRNA, in the rat hippocampus, and to evaluate to which extent the vitamin A deficiency could affect those temporal patterns.  Methods. Rats from control and vitamin A-deficient groups received a diet containing 4000 IU of vitamin A\/Kg diet, or the same diet devoided of vitamin A, respectively, during 3 months. Rats were maintained under 12 h-dark:12 h-dark conditions, during 10 days before the sacrifice. Circadian rhythms of CAT, GPx, RXR&#947; and CREB1 mRNA levels were determined by RT-PCR in hippocampus samples isolated every 4 h during a 24 h period. CAT and GPx enzymatic activities were also determined by kinetic assays. Regulatory regions of clock and antioxidant enzymes genes were scanned for E-box, RXRE and CRE sites.  Results. E-box, RXRE and CRE sites were found on regulatory regions of GPx and CAT genes, which display a circadian expression in the rat hippocampus. Vitamin A deficiency (VAD) phase shifted CAT, GPx and RXR&#947; endogenous rhythms without affecting circadian expression of CREB1.   Discussion. CAT and GPx expression and enzymatic activity are circadian in the rat hippocampus. The VAD affected the temporal patterns antioxidant genes expression, probably by altering circadian rhythms of its RXR receptors and clock factors; thus it would impair the temporal orchestration of hippocampal daily cognitive performance.","palabras_clave":"BIOLOGICAL RHYTHM|ANTIOXIDANT ENZYME|HIPPOCAMPUS|VITAMIN A"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39064,"idioma_id":5,"titulo":"Chaetophractus tarijensis (Xenarthra, Dasypodidae) ¿Un endemismo del Valle De Tarija (Bolivia)? Implicancias paleobiogeográficas","resumen":"          Chaetophractus tarijensis (Ameghino 1902) é um dasipódido restrito ao Pleistoceno do Vale de Tarija (Bolívia). A partir do estudo do exemplar tipo de C. tarijensis, dos materiales referidos a esta espécie e da comparação com outros Dasypodidae Euphractinae atuais, se conclui que os caracteres utilizados por Ameghino&nbsp; (e.g., o parco desenvolvimento da porção angular do ramo ascendente da mandíbula e a forma cilíndrica do último molariforme) não permitem diferenciá-la de C. villosus. Estas diferenças são também consistentes com os resultados obtidos por meio de uma análise de componentes principais, na qual C. tarijensis seria um sinônimo de C. villosus. Tais resultados são importantes do ponto de vista paleobiogeográfico, dado que seria outro caso de espécie originalmente proposta como endêmica do Vale de Tarija porém que, segundo nossos recentes estudos, não seria válida.   ","palabras_clave":"Cingulata|Euphractinae| South America| taxonomy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39066,"idioma_id":4,"titulo":"Revisiting the Evolutionary History and Roles of Protein Phosphatases with Kelch-Like Domains in Plants","resumen":"Protein phosphatases with Kelch-like domains (PPKL) are members of the phosphoprotein phosphatases family present only in plants and alveolates. PPKL have been described as positive effectors of brassinosteroid (BR) signaling in plants. Most of the evidence supporting this role has been gathered using one of the four homologs in Arabidopsis (Arabidopsis thaliana), BRASSINOSTEROID-INSENSITIVE1 SUPPRESSOR (BSU1). We reappraised the roles of the other three members of the family, BSL1, BSL2, and BSL3, through phylogenetic, functional, and genetic analyses. We show that BSL1 and BSL2\/BSL3 belong to two ancient evolutionary clades that have been highly conserved in land plants. In contrast, BSU1-type genes are exclusively found in the Brassicaceae and display a remarkable sequence divergence, even among closely related species. Simultaneous loss of function of the close paralogs BSL2 and BSL3 brings about a peculiar array of phenotypic alterations, but with marginal effects on BR signaling; loss of function of BSL1 is, in turn, phenotypically silent. Still, the products of these three genes account for the bulk of PPKL-related activity in Arabidopsis and together have an essential role in the early stages of development that BSU1 is unable to supplement. Our results underline the functional relevance of BSL phosphatases in plants and suggest that BSL2\/BSL3 and BSU1 may have contrasting effects on BR signaling. Given that BSU1-type genes have likely undergone a functional shift and are phylogenetically restricted, we caution that inferences based on these genes to the whole family or to other species may be misleading.","palabras_clave":"BSL phosphatases|brassinosteroids|evolution|Arabidopsis|Brassicaceae"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39067,"idioma_id":4,"titulo":"Thermoregulatory development and behavior of Ctenomys talarum pups during brief repeated postnatal isolation","resumen":"In altricial mammals, the role of the mother and siblings throughout pup´s early ontogeny is critical to determine ?normal? development in neonates. It has been reported that variations in parental investment during pups´ development affect thermoregulatory capacity, growth patterns, brain development and behavior during lifetime, such as spatial learning and memory in adults. Ctenomys talarum (tuco-tuco) is a solitary subterranean rodent, who inhabits complex burrows and exhibits developed spatial orientation abilities. Tuco-tuco´s pups display an altricial development, spending more than 80% of the time in contact with the mother. Throughout weaning period, pups display active exploratory behavior and improvements in their spatial capabilities. Then, we determined the effect of repeated brief postnatal isolations on the acquisition of physiological thermoregulation and the development of spatial learning capabilities in tuco-tuco´s pups. As it occurs in wild animals, daily brief isolations (30 min) did not affect the acquisition of adult´s body temperature nor resting metabolic rate´s development pattern. Moreover, behavioral response and adult spatial abilities of isolated pups were similar to that observed in non-isolated ones. Then, during periods of mother´s absence, minor physiological and behavioral adjustments, such as shivering and postural changes, are required to keep C. talarum pups within allostasis.","palabras_clave":"CTENOMYS TALARUM|BEHAVIOR|MATERNAL CARE|METABOLISM|PUPS|SPATIAL ABILITIES|THERMOREGULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39068,"idioma_id":4,"titulo":"Bronze electrodeposition from an acidic non-cyanide high efficiency electrolyte: tribological behaviour","resumen":"Bronze coatings were electrodeposited onto a rotating cylinder electrode from a novel noncyanide acid plating bath with high efficiency (92 %). Deposits were obtained from a phenol sulfonic acid bath and their morphology, phase composition and tribological behavior were characterized. Cyclic and linear sweep voltammetry were used to study the effect of organic additives on the reduction processes to achieve an adequate formulation. The resulting bronze deposit consisted of a mono &#945;-phase matrix with a 78 % Cu and 22 % Sn composition. Dry sliding wear tests were carried out employing a homemade ball on ring system and the coefficient of friction and wear resistance were quantified at different normal loads. Surface characterization of the bronze coatings showed that the resulting roughness is detrimental for the wear resistance of the deposit. This is evidenced by a higher friction coefficient and wear volume of Cu\/Sn compared to a conventionally electrodeposited copper coating.","palabras_clave":"BRONCE|ELECTRODEPOSITION|CYANIDE-FREE ELECTROLYTE|TRIBOLOGY|WEAR RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39069,"idioma_id":4,"titulo":"Dermal Papilla Cells improve the wound healing process and generate hair bud-like structures in grafted skin substitutes using Hair Follicle Stem Cells","resumen":"Tissue-engineered skin represents a useful strategy for the treatment of deep skin injuries and might contribute to the understanding of skin regeneration. The use of dermal papilla cells (DPCs) asa dermal component in a permanent composite skin with human hair follicle stem cells (HFSCs) was evaluated by studying the tissue-engineered skin architecture, stem cell persistence, hair regeneration, and graft-take in nude mice. A porcine acellular dermal matrix was seeded with HFSCs alone and with HFSCs plus human DPCs or dermal fibroblasts (DFs). In vitro, the presence of DPCs induced a more regular and multilayered stratified epidermis with more basal p63-positive cells and invaginations.  The DPC-containing constructs more accurately mimicked the skin architecture by properly stratifying the differentiating HFSCs and developing a well-ordered epithelia that contributed to more closely recapitulate an artificial human skin. This acellular dermal matrix previously repopulated in vitro with HFSCs and DFs or DPCsas the dermal componentwasgrafted in nude mice. The presence of DPCsin the composite substitute not only favored early neovascularization, good assimilation and remodeling after grafting but also contributed to the neovascular network maturation, which might reduce the inflammation process, resulting in a better healing process, with less scarring and wound contraction.  Interestingly, only DPC-containing constructs showed embryonic hair bud-like structures with cells of human origin, presence of precursor epithelial cells, and expression of a hair differentiation marker. Although preliminary, these findings have demonstrated the importance of the presence of DPCs for proper skin repair.","palabras_clave":"Skin substitutes|Dermal papilla cells|Hair follicle neogenesis|Hair follicles stem cells"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39070,"idioma_id":4,"titulo":"Modeling of dynamic mechanical properties of epoxy and epoxy-phenolic reinforced with multi wall-carbon nanotubes","resumen":"The viscoelastic properties of nanocomposites based on epoxy and epoxy-phenolic blend matrix reinforced  with multi wall-carbon nanotubes were studied. It was varied the content of carbon nanotube (0.2 and 0.5  wt.%) and its surface state (pristine vs. oxidized). The characterization of the nanocomposites was done by  means of infrared spectroscopy and chemical methods. From the viscoelastic properties of nanocomposites,  characteristic properties such as: storage modulus (E0), tan &#948; and damping peak (tan &#948;) were obtained. The  void content was also determined. Also, weibull statistics are used to represent the failure of secondary bonds  during the relaxation processes that lead to stiffness change over the full range of use temperatures. The  incorporation of phenolic resin to an epoxy matrix leads to an increase of the relaxation modulus. The glass  transition temperature of the epoxy-phenolic nanocomposites decrease when it is incorporated carbon  nanotubes, independently of its state (pristine or oxidized).","palabras_clave":"epoxy \/MWNTC,| phenolic \/epoxy \/MWNTC,|dynamic mechanical properties,|relaxation modulus modeling."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39071,"idioma_id":4,"titulo":"Energy-loss contribution to grazing scattering of fast He atoms from a silver surface","resumen":"The energy lost by helium atoms axially scattered from a Ag(110) surface is studied in order to investigate the influence of dissipative processes on fast atom diffraction spectra. In this work inelastic projectile distributions are evaluated within a semiclassical formalism that includes dissipative effects due to electron-hole excitations and [-110] directions the model predicts the presence through a friction force. For incidence along the [112] of multiple peaks in the energy-loss spectrum for a given impact energy. But these structures are completely washed out when the experimental dispersion of the incident beam is taken into account, giving rise to a smooth energy-loss distribution. Simulations including the experimental energy spread are in fairly good agreement channel. In addition, our results suggest that inelastic processes with available experimental data for the [112] produce an almost constant background in the transverse momentum distribution, except in the extremes of the momentum range where classical rainbow maxima appear. By adding elastic and inelastic contributions, experimental diffraction patterns are well reproduced.","palabras_clave":"Energy-loss|grazing scattering|fast atom diffraction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39072,"idioma_id":4,"titulo":"Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p-38 MAPK and Syk","resumen":"BACKGROUND:Neutrophils (PMN) are the first cells to infiltrate the lung after infection, and they play a significant protective role in the elimination of pathogen, by releasing preformed oxidants and proteolytic enzymes from granules and generating ROS, thus limiting inflammation by succumbing to apoptosis. In a previous study, we found marked differences in ROS-induced apoptosis between two Mycobacteriumtuberculosis (Mtb) strains, M and Ra, representative of widespread Mtb families in South America, i.e. Haarlem and Latin-American Mediterranean (LAM), being strain M able to generate further drug resistance and to disseminate aggressively.METHODS:In this study we evaluate the nature of bacteria-PMN interaction by assessing ROS production, apoptosis, lipid raft coalescence, and phagocytosis induced by Mtb strains.RESULTS:Dectin-1 and TLR2 participate in Mtb-induced ROS generation and apoptosis in PMN involving p38MAPK and Syk activation with the participation of a TLR2-dependent coalescence of lipid rafts. Further, ROS production occurs during the phagocytosis of non-opsonized bacteria and involves &#945;-glucans on the capsule. In contrast, strain M lacks the ability to induce ROS because of: 1) a reduced phagocytosis and 2) a failure in coalescence of lipid raft.CONCLUSIONS:The differences in wall composition could explain the success of some strains which stay unnoticed by the host through inhibition of apoptosis and ROS but making possible its replication inside PMN as a potential evasion mechanism. Innate immune res","palabras_clave":"MYCOBACTERIUM TUBERCULOSIS|NEUTROPHILS|APOPTOSIS|ROS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39073,"idioma_id":4,"titulo":"Optimal frame completions","resumen":"Given a finite sequence of vectors $mathcal F_0$ in $C^d$ we describe the spectral and geometrical structure of optimal frame completions of $mathcal F_0$ obtained by appending a finite sequence of vectors with prescribed norms, where optimality is measured with respect to a general convex potential. In particular, our analysis includes the so-called Mean Square Error (MSE) and the Benedetto-Fickus´ frame potential. On a first step, we reduce the problem of finding the optimal completions to the computation of the minimum of a convex function in a convex compact polytope in $R^d$. As a second step, we show that there exists a finite set (that can be explicitly computed in terms of a finite step algorithm that depends on $cF_0$ and the sequence of prescribed norms) such that the optimal frame completions with respect to a given convex potential can be described in terms of a distinguished element of this set. As a byproduct we characterize the cases of equalityin Lidskii´s inequality from matrix theory.","palabras_clave":"frame completions|majorization|Lidskii's inequality|Schur-Horn theorem"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39074,"idioma_id":4,"titulo":"Reflection and transmission coefficients of a single layer in poroelastic media","resumen":"Wave propagation in poroelastic media is a subject that find applications in many fields of research, from geophysics of the solid Earth to material science. In geophysics, seismic methods are based on the reflection and transmission of waves at interfaces or layers. It´s a relevant canonical problem, which has not been solved in explicit form, i.e., the wave response of a single layer, involving three dissimilar media, where the properties of the media are described by Biot´s theory. The displacement fields are recast in terms of potentials and the boundary conditions at the two interfaces impose continuity of the solid and fluid displacements, normal and shear stresses and fluid pressure. The existence of critical angles are discussed. The results are verified by taking proper limits-zero and 100 % porosity -- by comparison to the canonical solutions corresponding to single-phase solid (elastic) media and fluid media, respectively, and the case where the layer thickness is zero, representing an interface separating two poroelastic half-spaces. As examples, it was calculated the reflection and&nbsp; transmission coefficients for plane wave incident at a highly permeable and compliant fluid-saturated porous layer, and the case where the media are saturated with the same fluid.","palabras_clave":"PORELASTICITY|REFLECTIVITY|FINE LAYERS|WAVE PROPAGATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39075,"idioma_id":4,"titulo":"Seismic velocity and Q anisotropy in fractured poroelastic media","resumen":"A fluid-saturatedporoelasticisotropicmediumwithalignedfracturesbehavesasatransverselyisotropicandviscoelastic(TIV)mediumwhenthepredominantwavelengthismuchlargerthantheaveragedistancebetweenfractures.Aplanarfractureembeddedina fluidsaturatedporoelasticbackgroundmediumcanbemodeledasaextremelythinandcompliantporouslayer.P-wavestravelinginthistypeofmediuminducefluid-pressuregradientsatfracturesandmesoscopic-scaleheterogeneities,generating fluid flow andslow(diffusion)Biotwaves,causingattenuationanddispersionofthefastmodes(mesoscopicloss).Aporoelasticmedium withembeddedalignedfracturesexhibitssignificant attenuationanddispersioneffectsduetothismechanism,whichcanproperlyberepresentedatthemacroscalewithanequivalentTIVmedium.Inthiswork,weapplyasetofcompressibilityandshearharmonic finite-element(FE)experimentsonfracturedhighlyheterogeneousporoelasticsamplestodeterminethe fivecomplexandfrequencydependentstiffnessescharacterizingtheequivalentmedium.Theexperimentsconsiderbrineorpatchybrine-CO2saturatedsamplesandabrinesaturatedsamplewithaheterogeneous(fractal)skeletonwithfractures.WeshowthatfracturesinducestrongseismicvelocityandQanisotropy,bothforqPandqSVwaves,enhancedeither bypatchysaturationorframeheterogeneity.","palabras_clave":"FRACTURES|POROELASTICITY|ANISOTROPY|FINITE ELEMENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39076,"idioma_id":4,"titulo":"Optimal frame completions with prescribed norms for majorization","resumen":"Given a nite sequence of vectors F_0 in a d-dimensional complex Hilbert spaceH we characterize in a complete and explicit way the optimal completions ofF_0 obtained by appending a finite sequence of vectors with prescribed norms, where optimality is measured with respect to majorization (of the eigenvalues of the frame operators of the completed sequences). Indeed, we construct (in terms of a fast algorithm) a vector - that depends on the eigenvalues of the frameoperator of the initial sequence F_0 and the sequence of prescribed norms - that is a minimum for majorization among all eigenvalues of frame operators of completions with prescribed norms. Then, using the eigenspaces of the frame operator of the initial sequence F_0 we describe the frame operators of all optimal completions for majorization. Hence, the concrete optimal completionswith prescribed norms can be obtained using recent algorithmic constructions related with the Schur-Horn theorem.","palabras_clave":"frame completions|majorization|convex potentials|Schur-Horn theorem"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39077,"idioma_id":4,"titulo":"Saddle point problems, Bott-Duffin inverses, abstract splines and oblique projections","resumen":"In this note, we present links between several different areas in numerical analysis and operator theory. More precisely, we show that several saddle point problems are solvable in the presence of a property (called compatibility) between a positive operator and a closed subspace of a Hilbert space, and the same happens with certain abstract spline problems. These notions are related to the generalized Bott?Duffin inverse.","palabras_clave":"SADDLE POINT|SPLINES|PROJECTIONS|BOTT-DUFFIN INVERSE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39078,"idioma_id":4,"titulo":"Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors","resumen":"Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of their development. In humans, poor maternal nutrition is a major cause of intrauterine growth restriction which is associated with an increased risk of perinatal mortality and long-term morbidity. In addition, intrauterine growth restriction correlates with neurodevelopmental delays and alterations of brain structure and neurochemistry. While there is no doubt that maternal malnutrition is a principal cause of perturbed development of the fetal brain and that all nutrients have certain influence on brain maturation, proteins appear to be the most critical for the development of neurological functions. In the present study we assessed male and female mouse offspring, born to dams protein restricted during pregnancy and lactation, in physical growth and neurobehavioral development and also in social interaction, motivation, anxiety and depressive behaviors. Moreover, we evaluate the impact of the low protein diet on dams in relation to their maternal care and anxiety-related behavior given that these clearly affect pups development. We observed that maternal protein restriction during pregnancy and lactation delayed the physical growth and neurodevelopment of the offspring in a sex-independent manner. In addition, maternal undernutrition negatively affected offspring's juvenile social play, motivation, exploratory activity and risk assessment behaviors. These findings show that protein restriction during critical periods of development detrimentally program progeny behavior.","palabras_clave":"NEURODEVELOPMENT|MATERNAL CARE|SOCIAL BEHAVIOR|ANXIETY-RELATED BEHAVIOUR|DEPRESSIVE-RELATED|PERINATAL|PROTEIN|MALNUTRITION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39079,"idioma_id":4,"titulo":"Rhodamine B doped silica encapsulation matrices for the protection of photosynthetic organisms","resumen":"tAn advanced encapsulation matrix that efficiently protects microalgae from harmful UV light withoutcausing toxicity to the entrapped culture is developed based on the electrostatic adsorption of the dyeRhodamine B on silica preformed particles during sol-gel synthesis. The three microalgae (Chlorella vul-garis, Pseudokirchneriella subcapitata and Chlamydomonas reinhardtii) were previously immobilized inalginate following the Two-step procedure. Once entrapped in the silica gel, Rhodamine B act as an innercut-off filter, protecting the encapsulated organisms from UV radiation. This matrix allows the steril-ization of encapsulation devices without affecting the viability of the entrapped microalgae cells. Thecondensation of Si(IV) in the presence of silica particles with adsorbed dye generates silica matrices withgood mechanical stability. Furthermore; no appreciable differences in microstructure, as assessed bySAXS (Small Angle X-ray Scattering), are caused by the addition of the dye.","palabras_clave":"algae entrapment|sol-gel|biosensors|UV-protection"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39080,"idioma_id":10,"titulo":"Experiência, narrativa e conhecimento: a perspectiva do psiquiatra e a do usuário","resumen":"This study, conducted in a partnership composed by UFRJ, UNICAMP and UFBa, wanted to investigate the experience of people with a diagnosis of schizophrenia spectrum disorder, in treatment in CAPS, and the experience of psychiatrists inserted in the public mental health care services. Narratives related to  health and illness, in the case of people with schizophrenia, and narratives about the process of formulation of the schizophrenia diagnosis, prognosis and treatment in the case of psychiatrists, were studied. This is a qualitative, multicenter study, informed by the theoretical approaches of Interpretative Phenomenological Analysis and Medical Anthropology held in Campinas, Rio de Janeiro and Salvador. The main methodological tool used for the production of narratives were focus groups. Procedures of the Explicitation Interview were incorporated. The categories identified in this study were Illness Experience, Diagnosis of Schizophrenia, Social Stigma, Recovery Experience, Treatment and dynamic context of CAPS. The narratives that composed each category were presented and discussed in order to give visibility to the elements characterizing the narratives-experiences, indicating how it configures its complexity.","palabras_clave":"experiencia de la enfermedad|narrativa|Esquizofrenia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39081,"idioma_id":4,"titulo":"Muscular Anatomy of the Forelimbs of the Lesser Grison (Galictis cuja), and a Functional and Phylogenetic Overview of Mustelidae and Other Caniformia","resumen":"The extrinsic and intrinsic forelimb musculature of the lesser grison (Galictis cuja), a short-legged mustelid of southern South America, is studied for the first time. We present descriptions, muscular maps, and weight data. Muscular anatomy description of the lesser grison provides the framework for discussing the myological diversity of mustelids and other caniforms, for addressing nomenclatural problems (such as synonymy and homonymy), and for highlighting some functional and phylogenetically informative traits.We recognize in the lesser grison features shared by all mustelid species, and some other caniforms, especially mephitids, such as the presence of rhomboideus profundus, an angular head of triceps brachii, and, apparently, the absence of a flexor digitorum brevis manus. An unexpected record of articularis humeri, a proximal origin of the brachioradialis, and the absence of the tensor fascia antebrachii are recorded for this species. As other ictonychines and mustelines, Galictis cuja possesses stronger and subdivided protractors and sagittal rotators of the forelimbs, as well as shoulder and elbow extensors. These features allow for resistance in landing during bounds and increase the stride length during epigean and subterranean crouched locomotion. Powerful neck musculature assists during hunting and carrying of prey. Weakness of some retractors and intrinsic flexors is related to a relatively minor importance of the forelimbs as propellers during bounding and the lack of other specializations. The configurationof the rhomboideus and the absence of coracobrachialis seem to be informative at the subfamiliar level within Mustelidae. The comprehensive and comparative review of available information leads us to propose possible solutions to old nomenclatural problems and of identification. This allowsus to reassess of some myological features as diagnostic of caniform clades.","palabras_clave":"Caniformia|Forelimb|Galictis|Mustelidae|Myology|Phylogeny"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39082,"idioma_id":4,"titulo":"Corrosion Resistance of Al-Cu Alloys in Function of the Microstructure","resumen":"Aluminum and its alloys are characterized by low density, high electrical and thermal conductivity, and good resistance to corrosion in certain media such as air. The mechanical strength alloy is achieved. The objective of the present research consist on studying the type of structure (columnar, equiaxed or with columnar to equiaxed transition, CET) using parameters of the solidification process and electrochemical parameters in Al, Cu and Al-Cu alloys with different concentrations. In order to obtain columnar, equiaxed and CET structures, the alloys were directionally solidified upwards in an experimental set up with a set of thermocouples in the samples which permit to determine the time dependent profiles during the process. The electrochemical studies of the samples were realized by using an electrochemical impedance spectroscopy (EIS) technique and potentio-dynamic polarization curves immersed in 3% NaCl solution at room temperature. In general, we observed that the susceptibility to corrosion of the different structures depends on the size of the secondary dendritic spacing and the proportion of Al2Cu phase and Al-rich phase.","palabras_clave":"Al-Cu ALLOYS,|CORROSION|ELECTROCHEMICAL IMPEDANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39083,"idioma_id":4,"titulo":"Effects of coexisting spin disorder and antiferromagnetism on the magnetic behavior  of nanostructured (Fe79Mn21)1xCux alloys","resumen":"We report a magnetic study on nanostructured (Fe79Mn21)1xCux (0.00x0.30) alloys usingstatic magnetic measurements. The alloys are mainly composed by an antiferromagneticfcc phaseand a disordered region that displays a spin-glass-like behavior. The interplay between theantiferromagnetic and magnetically disordered phases establishes an exchange anisotropy thatgives rise to a loop shift at temperatures below the freezing temperature of moments belonging tothe disordered region. The loop shift is more noticeable as the Cu content increases, which alsoenhances the spin-glass-like features. Further, in the x¼0.30 alloy the alignment imposed byapplied magnetic fields higher than 4 kOe prevail over the configuration determined by thefrustration mechanism that characterizes the spin glass-like phase.","palabras_clave":"FeMnCu alloys|Exchange bias |ball milling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39084,"idioma_id":4,"titulo":"Spectral evolution of the SU(4) Kondo effect from the single impurity to the two-dimensional limit","resumen":"We describe the evolution of the SU(4) Kondo effect as the number of magnetic centers increases from one impurity to the two-dimensional (2D) lattice. We derive a Hubbard-Anderson model which describes a 2D array of atoms or molecules with twofold orbital degeneracy, acting as magnetic impurities and interacting with a metallic host. We calculate the differential conductance, observed typically in experiments of scanning  tunneling spectroscopy, for different arrangements of impurities on a metallic surface: a single impurity, a periodic square lattice, and several sites of a rectangular cluster. Our results point towards the crucial importance of the orbital degeneracy and agree well with recent experiments in different systems of iron(II) phtalocyanine  molecules deposited on top of Au(111) [N. Tsukahara et al., Phys. Rev. Lett. 106, 187201 (2011)], indicating an experimental realization of an artificial 2D SU(4) Kondo-lattice system.","palabras_clave":"Kondo effect|SU4) symmetry|scanning tunneling microscopy|Fe phtalocianine"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39085,"idioma_id":5,"titulo":"Nueva asociación de mamíferos del Paleógeno en el este de la Patagonia (provincia de Chubut, Argentina): implicancias biocronológicas y paleobiogeográficas","resumen":"Los fósiles de mamíferos continentales hallados en la localidad Barrancas Blancas, ubicada en la Estancia La Argentina, cerca de Camarones, en el sudeste de la provincia del Chubut, Argentina, constituyen una nueva asociación faunística del Paleógeno de Patagonia. El afloramiento en dicha localidad está integrado, desde la base al techo, por sedimentitas continentales y marinas asignadas a la Formación Sarmiento y la Formación Chenque, respectivamente. En la sección inferior de la Formación Sarmiento se encontraron mamíferos fósiles, principalmente Xenarthra, Notoungulata y Litopterna, que conforman la nueva asociación. Se han podido reconocer los siguientes taxones: Xenarthra, Cingulata, Dasypodidae, Euphractinae, Eutatini: Meteutatus percarinatus; Euphractini: Archaeutatus sp.; Parutaetus; Prozaedyus; Peltephilidae: Peltephilus undulatus; Glyptodontidae, Glyptatelinae indet.; Cingulata incertae sedis: Machlydotherium ater; Phyllophaga: Pseudoglyptodon; Notoungulata, Notohippidae; Rhynchippinae: Rhynchippus pumilus; Rhynchippinae indet.; Interatheriidae: Eopachyrucos pliciferus, Proargyrohyrax curanderensis; Archaeohyracidae:  Pseudhyrax eutrachytheroides; Leontiniidae: Leontinia gaudryi; Isotemnidae indet.; Litopterna, Proterotheriidae indet. Los nuevos hallazgos paleontológicos confirmarían en principio una Edad Mamífero Deseadense para estos niveles por la presencia de los géneros Leontinia y Rhynchippus. Sin embargo, la diversidad de xenartros y de varios grupos de tipoterios (Interatheriidae y Archaeohyracidae) presentes en Barrancas Blancas indicarían una fauna de EM Tinguiriquense o incluso podría estar representando una fauna equivalente a los niveles de La Cantera (Gran Barranca), cuyas dataciones de ca. 30 Ma estarían indicando un lapso post-Tinguiririquense a pre-Deseadense. Desde el punto de vista paleobiogeográfico Barrancas Blancas correspondería a la localidad patagónica más oriental con fauna paleógena de las edades mencionadas anteriormente.","palabras_clave":"CHUBUT|MAMÍFEROS|DESEADENSE|TINGUIRIRIQUENSE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39086,"idioma_id":4,"titulo":"Diversity and composition of cactus species along an altitudinal gradient in the Sierras del Norte Mountains (Córdoba, Argentina)","resumen":"Cacti are important elements of the flora in many ecosystems of the Americas. However, the factors that determine their richness and composition are not well known, particularly at the regional scale. The aim of this work was to study the patterns of cactus richness (both species and growth forms) and composition in the Sierras del Norte mountain range (Córdoba Province, Argentina). Species presence was recorded at 55 sites covering an altitudinal gradient from 203 to 970 m. Twenty four species from eight genera were recorded in the area. Total species richness and growth form richness decreased with increasing altitude. The richness of columnar and short columnar species decreased with increasing altitude, whereas richness of globose species increased. Opuntioid richness did not respond to altitude. Species composition was strongly related to altitude. Gymnocalycium bruchii and Parodia erinaceae occurred at sites located at higher altitudes, whereas at sites at lower altitudes, G. schickendantzii, Stetsonia coryne and Cleistocactus baumannii, among other species, were present. Our results highlight the importance of altitude in shaping the distribution of species and growth forms in the Sierras del Norte Mountains.","palabras_clave":"Alpha and Beta Diversity|Cactaceae|Growth forms|Environmental gradients"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39087,"idioma_id":5,"titulo":"Composición de especies leñosas en comunidades invadidas en montañas del centro de Argentina: su relación con factores ambientales locales","resumen":"El reemplazo de bosques nativos por comunidades secundarias dominadas por leñosas exóticas es una realidad que apremia la conservación de los Bosques Chaqueños en las Sierras de Córdoba, Argentina Central, ya que afecta procesos directamente vinculados con el funcionamiento ecosistémico. En este contexto, adquiere relevancia teórica y aplicada entender los factores que subyacen a dicho reemplazo, particularmente en remanentes de vegetación próximos a urbanizaciones. En este tipo de ambiente, altamente perturbado y bajo una alta presión de propágulos, es esperable que la heterogeneidad local propia de ambientes montañosos condicione los patrones de invasión. En consecuencia, nos propusimos indagar si en un área invadida de las Sierras Chicas de Córdoba: (1) ¿se observa una segregación espacial a escala local entre especies leñosas exóticas y\/o nativas dominantes?, y 2) si existe esa segregación, ¿está asociada a variables ambientales? Se relevaron 31 parcelas donde se realizaron censos de especies leñosas y se midieron variables topográficas y edáficas. Se identificaron cinco comunidades de leñosas coexistiendo: (1) Bosques dominados por Ligustrum lucidum; (2) Bosques mixtos dominados por Lithraea molleoides y Celtis australis; (3) Matorrales de Condalia buxifolia; (4) Matorrales de Cotoneaster glaucophyllus, y (5) Pajonales con emergentes de Pyracantha angustifolia. Estas comunidades se asociaron diferencialmente a las variables topográficas y edáficas locales. La segregación ambiental observada sugiere que las especies invasoras tienen una capacidad potencial para colonizar casi todos los ambientes en el área de estudio (variando la identidad de la invasora). En conjunto, los patrones descriptos, aunque circunscriptos a un área de Chaco Serrano con un avanzado grado de invasión, plantearían un escenario de posible expansión de las leñosas exóticas sobre las comunidades nativas.","palabras_clave":"invasiones biologicas|segregacion ambiental|Bosque Chaqueño"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39088,"idioma_id":4,"titulo":"Synthesis and multi-technique characterization of nickel loaded MCM-41 as potential hydrogen storage materials","resumen":"Ni\/MCM-41 samples have been successfully prepared by wet impregnation method with different degrees of metal loading. Various techniques including X-ray diffraction, N2 adsorption desorption, transmission electron microscopy, inductively coupled plasma atomic emission spectroscopy, electron microprobe analysis, UVVis diffuse reflectance spectra, infrared analysis, adsorption of pyridine coupled to infrared spectroscopy and hydrogen adsorption at 77 K at high and low pressure conditions were employed for the materials characterization. The Ni loading degree had a marked influence on the structural, chemical, acid and hydrogen storage properties of the samples. Thus, a low Ni loading favors the presence of highly dispersed Ni species responsible of the Lewis acidity. These species would promote hydrogen-favorable sites leading to a positive effect on the hydrogen storage capacity.","palabras_clave":"MCM41|Nickel|Hydrogen storage"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39089,"idioma_id":4,"titulo":"Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet induced NASH model","resumen":"Hepatocyte cell death is a key feature of nonalcoholic steatohepatitis (NASH). As the contribution of specific caspases remains unclear, our aim was to ascertain the effect of caspase 3 suppression on liver injury and fibrogenesis.METHODS:C57BL\/6 wild-type (WT) and caspase 3 knock out (Casp3 (-\/-)) mice were placed on a methionine- and choline-deficient (MCD) diet for 6 weeks to induce steatohepatitis and liver fibrosis. Thereafter, liver injury, liver fibrosis and hepatocellular apoptosis were quantified in liver sections. Additionally, expression of proteins associated with liver inflammation and fibrogenesis was analyzed.RESULTS:WT mice fed MCD diet showed marked activation of caspase 3 in hepatocytes, in conjunction with steatohepatitis and increased hepatic triglyceride levels, hepatocyte ballooning, inflammation and fibrosis. Casp3 (-\/-) mice fed the MCD diet showed similar serum aminotransferase levels and NAFLD activity scores (NAS) compared with WT MCD-fed mice. However, Casp3 (-\/-) mice on the MCD diet showed a marked reduction in expression of transcripts for profibrogenic genes, which translated into reduced hepatic collagen deposition. These changes were associated with decreased levels of apoptosis, and a significant reduction in the expression of cytokines involved in inflammatory signaling. Casp3 (-\/-) mice on the MCD showed a reduction in expression of chemokine receptor 2 (CCR2) leading to ameliorated infiltration of inflammatory lymphocyte antigen 6 complex, locus C1 (Ly6c) positive monocytes.CONCLUSION:These findings support a prominent role for hepatocyte caspase 3 activation in NASH-related apoptosis, fibrogenesis and fibrosis which in part is mediated via CCR2-dependent infiltration of Ly6c positive monocytes.","palabras_clave":"Caspase|NASH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39090,"idioma_id":4,"titulo":"NLRP3 Inflammasome Activation is required for Fibrosis Development in NAFLD","resumen":"Background & Aims: NLR-inflammasomes, caspase-1 activation platforms critical for processing key pro-inflammatory cytokines, have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). As the direct role of the NLRP3 inflammasome remains unclear we tested effects of persistent NLRP3 activation as a contributor to NAFLD development and in particular as a modulator of progression from benign hepatic steatosis to steatohepatitis during diet-induced NAFLD. Methods: Gain of function tamoxifen-inducible Nlrp3 knock-in mice allowing for in vivo temporal control of NLRP3 activation and loss of function Nlrp3 knockout mice were placed on short-term choline-deficient amino acid-defined (CDAA) diet, to induce isolated hepatic steatosis or long-term CDAA exposure, to induce severe steatohepatitis and fibrosis, respectively. Expression of NLRP3 associated proteins was assessed in liver biopsies of a well-characterized group of patients with the full-spectrum of NAFLD. Results: Nlrp3-\/- mice were protected from long-term feeding CDAA induced hepatomegaly, liver injury, and infiltration of activated macrophages. More importantly, Nlrp3-\/- mice showed marked protection from CDAA-induced liver fibrosis. After 4 weeks on CDAA diet, WT animals showed isolated hepatic steatosis while Nlrp3 knock-in mice showed severe liver inflammation, with increased infiltration of activated macrophages, and early signs of liver fibrosis. In liver samples of patients with NAFLD, inflammasome components were significantly increased in those patients with NASH when compared to those with non-NASH NAFLD with mRNA levels of NLRP3 and pro-IL1 beta correlated to the area of Sirius Red Staining. Conclusions: Our study uncovers a crucial role for the NLRP3 inflammasome in the development of non-alcoholic fatty liver disease. These findings may lead to novel therapeutic strategies aimed at halting the progression of hepatic steatosis to the more severe forms of this disease.","palabras_clave":"NLRP3|inflammation|liver fibrosis|NASH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39091,"idioma_id":5,"titulo":"Paleontología y cronología del Cuaternario de las provincias de Corrientes y Formosa, Argentina","resumen":"En los últimos años ha habido un importante avance en el conocimiento de la paleontología en el actual territorio de las provincias de Corrientes y Formosa (Argentina). Las  tareas incluyeron la extracción y determinación de numerosos ejemplares (la mayoría con estricto control estratigráfico y geográfico) y nuevas dataciones absolutas (C14 y OSL) de las unidades portadoras. En la provincia de Corrientes, el Pleistoceno está representado por las Formaciones Toropí  y Yupoí. Dataciones OSL efectuadas en el área del Arroyo Toropí sugieren una edad correspondiente al Pleistoceno Superior. Hasta el momento, la paleofauna exhumada incluye en su mayoría mamíferos y, en menor medida, reptiles. Esta asociación está constituida principalmente por taxones típicamente pampeanos, aunque es destacable la presencia de ciertos elementos propios de ámbitos más intertropicales. A su vez, en la provincia de Formosa, los materiales con buena procedencia geográfica y estratigráfica provienen de la Formación Río Bermejo. Dataciones OSL y C14  en Villa Escolar sugieren una antigüedad correspondiente al lapso Pleistoceno Superior-Holoceno. Como en el caso anterior, la mayoría de los taxones corresponden a mamíferos y, en menor medida, peces y reptiles. Todos los taxones en esta provincia (excepto el Pampatheriidae Holmesina paulacoutoi) indican la presencia de ambientes fríos y áridos\/semiáridos. El avance en el conocimiento de las asociaciones paleofaunísticas de estas áreas resulta clave, ya que permite comparaciones más precisas con otras regiones de América del Sur.","palabras_clave":"Pleistoceno|Holoceno|Norte de Argentina|Diversidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39092,"idioma_id":5,"titulo":"Metodologías para la obtención de puntos cuánticos de cristales semiconductores de CdSe (Methodologies for CdSe semiconductor quantum dots synthesis)","resumen":"El estudio de puntos cuánticos (QDots) de semiconductores de CdSe es de gran interés debido a los efectos de confinamiento cuántico que permiten variar la energía del ?band gap?, Egap  (banda prohibida; es decir, la diferencia de energía entre las bandas de valencia y conducción) de los nanocristales mediante la regulación del tamaño de los mismos a través de diversos métodos sintéticos. Existe una amplia variedad de metodologías de síntesis, dentro de las cuales la más  comúnmente utilizada es el método de inyección en caliente.    En este trabajo se expone la síntesis de puntos cuánticos de CdSe llevada a cabo mediante una de las tantas variantes de este método.","palabras_clave":"Síntesis|Puntos Cuánticos CdSe"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39093,"idioma_id":5,"titulo":"Promoción del compromiso : una experiencia educativa basada en la teoría de las inteligencias múltiples","resumen":"El trabajo que se presenta tiene como objetivo dar a conocer una experiencia educativa desarrollada en el marco de la teoría de las inteligencias múltiples en educación primaria y las implicancias educativas sobre el compromiso de los alumnos hacia el aprendizaje. El proyecto se lleva a cabo con alumnos de 6to grado, en el área de ciencias sociales. La propuesta presentada se formula en la necesidad de desarrollar diseños instructivos basados en tareas académicas diversas, originales, auténticas y contextualizadas para promover la implicancia hacia el trabajo en el aula. Para conocer las impresiones de los alumnos sobre la propuesta se realizaron preguntas a modo de encuesta y se realizaron observaciones de clase para recolectar información acerca de la experiencia. Los resultados muestran que los alumnos se perciben con mayor compromiso afectivo, conductual y cognitivo cuando se explicitan los objetivos y criterios de valoración, cuando las tareas son presentadas en formato novedoso -diverso-, auténtico y se ofrecen oportunidades para participar.","palabras_clave":"compromiso  educación primaria.|tareas académicas|inteligencias múltiples|diseño curricular,"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39094,"idioma_id":4,"titulo":"Carbohydrate PEGylation, an approach to improve pharmacological potency","resumen":"Conjugation with polyethylene glycol (PEG), known as PEGylation, has   been widely used to improve the bioavailability of proteins and low   molecular weight drugs. The covalent conjugation of PEG to the   carbohydrate moiety of a protein has been mainly used to enhance the   pharmacokinetic properties of the attached protein while yielding a more   defined product. Thus, glycoPEGylation was successfully applied to the   introduction of a PEGylated sialic acid to a preexisting or   enzymatically linked glycan in a protein. Carbohydrates are now   recognized as playing an important role in host pathogen interactions in   protozoal, bacterial and viral infections and are consequently   candidates for chemotherapy. The short in vivo half-life of low   molecular weight glycans hampered their use but methods for the covalent   attachment of PEG have been less exploited. In this review, information   on the preparation and application of PEG-carbohydrates, in particular   multiarm PEGylation, is presented.","palabras_clave":"bioavailability|carbohydrates|conjugates|glycoPEGylation|multivalent PEGylation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39095,"idioma_id":4,"titulo":"The Other Fiesta. Bolivians in Argentina","resumen":"This short article analyze the sense of community articulated through dance and popular celebrations by the Bolivian immigrants in Argentina. The focus of the note is on the 'performances' of the fiesta of 'Virgen de Copacabana' as it is portrayed by Martín Rejtman in 'Copacabana' (2006) and a reflection on the possibilities of the documentary form to give an account of the 'other' as a non exotic culture. ","palabras_clave":"Documental|Comunidad inmigrante|Danza|Fiestas populares"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39096,"idioma_id":5,"titulo":"Los gestos y la enseñanza de palabras poco familiares: ¿Cuándo emplean las maestras información gestual?","resumen":"El presente trabajo tiene por objeto analizar los gestos que las maestras emplean en el tratamiento de vocabulario poco familiar en clases de Ciencias Sociales de la escuela primaria. El corpus está compuesto por secuencias interaccionales (Goodwin & Heritage, 1990; Schegloff, 1990) incluidas en 12 situaciones de enseñanza videofilmadas en 1°, 3° y 5° grado de 4 escuelas, dos rurales y dos urbanas de la provincia de Córdoba, Argentina. En las secuencias las maestras empleaban términos que eran poco familiares para los niños. Se llevó a cabo un análisis cualitativo (Strauss & Corbin, 1991) que permitió comparar distintas secuencias en las que las maestras explican, definen o reparan las mismas palabras. Los resultados mostraron que, a diferencia de lo señalado en otros trabajos el uso de gestos por parte de las maestras no se encuentra únicamente asociado al término poco familiar empleado sino que se produce en respuesta a acciones verbales y\/o gestuales de los niños que muestran una posible falta de comprensión conceptual.","palabras_clave":"GESTOS |INTERACCIÓN EN EL AULA |ENSEÑANZA |VOCABULARIO POCO FAMILIAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39097,"idioma_id":5,"titulo":"Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados","resumen":"La exposición a estímulos novedosos es un protocolo simple de emplear que involucra múltiples sistemas y procesos de memoria como codificación, consolidación y recuperación de la información. Esto hace plausible de emplear como un tratamiento útil para estudiar los mecanismos comportamentales, fisiológicos y moleculares implicados en esta función cognitiva. En este trabajo se presentarán estudios en modelos animales que dan cuenta de cómo la exploración de un ambiente novedoso puede ser útil para mejorar o deteriorar la memoria, en diferentes períodos ontogenéticos. Además, se presentarán investigaciones que demuestran la participación de los diversos sistemas de neurotransmisión en este fenómeno así como los mecanismos moleculares implicados en este tipo de tratamiento. De este modo este tipo de tratamiento, no invasivo y sencillo de aplicar, adquiere relevancia para la ciencia aplicada como una posible alternativa para el desarrollo de estrategias de intervención en la temática.","palabras_clave":"NOVEDAD|MEMORIA|NEUROTRASMICION|MECANISMOS MOLECULARES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39098,"idioma_id":4,"titulo":"Antiproliferative and Quinone Reductase Inducing activities of Withanolides derivatives","resumen":"Two new and five known withanolides (jaborosalactones 2, 3, 4, 5, and 24) were isolated from the leaves  of Jaborosa runcinata Lam. We also obtained some derivatives from jaborosalactone 5, which resulted to  be the major isolated metabolite. The natural compounds as well as derivatives were evaluated for their  antiproliferative activity and the induction of quinone reductase 1 (QR1; NQ01) activity. Structureeactivity  relationships revealed valuable information on the pharmacophore of withanolide-type compounds.  Three compounds of this series showed significantly higher antiproliferative activity than  jaborosalactone 5. The effect of these compounds on the cell cycle was determined. Furthermore, the  ability of major compounds to induce QR1 was evaluated. It was found that all the active test compounds  are monofunctional inducers that interact with Keap1. The most promising derivatives prepared from  jaborosalactone 5 include (23R)-4b,12b,21-trihydroxy-1,22-dioxo-12,23-cycloergostan-2,5,17,24-tetraen-  26,23-olide (18) and (23R)-21-acetoxy-12b-hydroxy-1,22-dioxo-12,23-cycloergostan-2,5,17,24-tetraen-  26,23-lactame (20).","palabras_clave":"Antiproliferative activity|Quinone Reductase|Metabolitos Secundarios|Withanólidos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39099,"idioma_id":5,"titulo":"Estableciendo límites: distribución geográfica de los micromamíferos terrestres (Rodentia y Didelphimorphia) de Patagonia centro-oriental","resumen":"Se analiza la distribución geográfica de las especies de micromamíferos no voladores del sector costero de Patagonia central. Esta región es relevante ya que aquí se produce el engranaje entre las unidades florísticas más importantes de la Patagonia extraandina, la Provincia Fitogegráfica (PF) del Monte y la PF Patagónica. Los objetivos de este trabajo son aportar datos novedosos sobre la distribución geográfica de los micromamíferos costeros entre los 41°30?S y 46°00?S, describir la composición taxonómica de los ensambles y explorar la fidelidad de sus especies con las unidades vegetacionales mayores. La información fue obtenida de trampeos y muestras de egagrópilas; también se consultaron colecciones científicas y bibliografía. Se trampearon 557 ejemplares y se registraron al menos 4740 individuos a partir de egagrópilas. Se documentaron 2 especies de marsupiales, 12 de sigmodontinos, dos de cávidos, Ctenomys ?cuyo panorama específico es incierto? y 2 de múridos introducidos. Se recopilaron 100 localidades con información sobre micromamíferos. Zoogeográficamente, el contacto entre la PF del Monte y la PF Patagónica en el sector costero no es una línea bien definida, sino un ecotono que se extiende desde el río Chubut hasta Camarones en el cual se interdigitan elementos característicos de ambas unidades. La penetración de especies vinculadas a la PF del Monte hacia localidades australes se produce por el sector costero hasta, aproximadamente, Puerto Deseado (47°45?S). Por otra parte, los ensambles de la PF Patagónica se diferencian claramente en los sectores elevados de las mesetas del sur chubutense, poniendo en evidencia la influencia de la altitud, como condicionante de la humedad, la temperatura y, en última instancia, la vegetación, sobre la distribución de las especies de micromamíferos.","palabras_clave":"ROEDORES|MARSUPIALES|MONTE|ESTEPA PATAGONICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39100,"idioma_id":4,"titulo":"Mixed Finite Element Analysis of Eigenvalue Problems on Curved Domains","resumen":"In this paper we present a theoretical framework for the analysis of the  numerical approximations of a particular class of eigenvalue problems by mixed\/hybrid methods. More precisely, we are interested in eigenproblems which are defined over curved domains or have internal curved boundaries and which may be associated with non-compact inverse operators. To do this, we consider external domain approximations O_h of the original domain O, i.e., O_h not subset O. Sufficient conditions to ensure good convergence properties and optimal error bounds for the external approximations of the eigenfunction\/eigenvalue pairs are established. Then, these results are applied to the study of the Stokes eigenvalue problem with slip boundary condition defined on a curved non-convex two-dimensional domain.","palabras_clave":"Spectral Approximation Theory|Mixed or Hybrid Methods|Curved Domains|Stokes Eigenvalue Problem|Slip Boundary Conditions"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39101,"idioma_id":4,"titulo":"Sequential determination of lead and cobalt in tap water and foods samples by fluorescence","resumen":"In this work, a new procedure was developed for the separation and preconcentration of lead(II) and cobalt(II) in several water and foods samples. Complexes of metal ions with 8-hydroxyquinolein (8-HQ) were formed in aqueous solution. The proposed methodology is based on the preconcentration\/separation of Pb(II) by solid-phase extraction using paper filter, followed by spectrofluorimetric determination of both metals, on the solid support and the filtered aqueous solution, respectively. The solid surfase fluorescence determination was carried out at &#955;em = 455 nm (&#955;ex = 385 nm) for Pb(II)-8-HQ complex and the fluorescence of Co(II)-8-HQ was determined in aqueous solution using &#955;em = 355 nm (&#955;ex = 225 nm). The calibration graphs are linears in the range 0.14 to 8.03 104  &#956;g L&#8722;1 and 7.3× 10&#8722;2  to 4.12 × 103 &#956;g L&#8722;1, for Pb(II) and Co(II), respectively, with a detection limit of 4.3 10&#8722;2 and 2.19 10&#8722;2 &#956;g L&#8722;1 (S\/N = 3).  The developed methodology showed good sensitivity and adequate selectivity and it was successfully applied to the determination of trace amounts of lead and cobalt in tap waters belonging of different regions of Argentina and foods samples (milk powder, express coffee, cocoa powder) with satisfactory results. The new methodology was validated by electrothermal atomic absorption spectroscopy with adequate agreement. The proposed methodology represents a novel application of fluorescence to Pb(II) and Co(II) quantification with sensitivity and accuracy similar to atomic spectroscopies.","palabras_clave":"LEAD-COBALT|8-HYDROXYQUINOLINA|LUMINECESCE|FOODS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39102,"idioma_id":4,"titulo":"Effect of the Puyehue-Cordon Caulle volcanic complex eruption on crustacean zooplankton of Andean lakes","resumen":"We studied the effect of volcanic ash on the crustacean zooplankton (mainly cladocerans) in theAndean North-Patagonian lakes that were affected by the eruption of the Puyehue-Cordón Caulle complex.The study was carried out at three different scales: sub cellular, population and ecosystemic. Cladocerans arefilter feeding organisms that cannot distinguish between food (algae less than 30 &#956;m) and suspended ash,therefore when feeding they ingest this material. The ash affected negatively the individuals at a biochemicallevel, increasing the oxidative stress reacting enzymes like Glutation-S-transferase and the biomarker Acetylcholinesterase. At the population level, we recorded a decrease in survival and fecundity, in particular, whenash concentration exceeded 8 mg\/L, we observed that individuals did not reach adulthood. At the ecosystemlevel, we recorded a significant decrease of the intermediate trophic level (primary consumers) althoughproducers were positively enhanced by the eruption. The absence of these primary consumers may affect uppertrophic levels like fishes. Later, in the year following the eruption, we observed the resurgence of zooplanktonpopulations suggesting a fast recovery from the initial conditions.","palabras_clave":"cenizas volcanicas|lagos andinos|plancton"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39103,"idioma_id":4,"titulo":"Histological Changes in the Retina Provoked by Lithium Treatment in a Nocturnal Rodent (Lagostomus maximus maximus)","resumen":"Abstract  Daily morphological variations have been previously described  in the viscacha (Lagostomus maximus maximus) retina.  The aim of this work was to determine the effects of lithium  administration on the histology of retinas from this nocturnal  rodent since lithium is a drug that has been shown to  affect different parameters of circadian rhythms. Adult male  viscachas were divided into 2 groups, injected daily with lithium  chloride or vehicle for 35 days, and sacrificed at 08: 00,  16: 00, and 24: 00 h for light and electron microscopy studies.  The following morphometric parameters were analyzed: the  thickness of the photoreceptor layer, the rod outer and inner  segments, and the outer nuclear layer. The control group displayed  a true daily cycle of photoreceptor renewal similar to  that previously reported by us for (untreated) viscachas in  their normal habitat. In all lithium-treated groups, we did not  observe histological changes in the thickness measurement  of the retinal layers. In these groups, the retinas presented  ultrastructural characteristics similar to those observed in  control animals sacrificed at 24: 00 h. In conclusion, chronic  lithium administration abolished the daily histological  rhythm in the viscacha retina, probably via inhibition of the  phagocytosis process in pigment epithelial cells.","palabras_clave":"Retina ·|Lithium|Histology|Lagostomus"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39104,"idioma_id":5,"titulo":"Metodologías para la obtención de puntos cuánticos de cristales semiconductores de CdSe","resumen":"El estudio de puntos cuánticos (QDots) de semiconductores de CdSe es de gran interés debido a los efectos de confinamiento cuántico que permiten variar la energía del ?band gap?, Egap (banda prohibida; es decir, la diferencia de energía entre las bandas de valencia y conducción) de los nanocristales mediante la regulación del tamaño de los mismos a través de diversos métodos sintéticos. Existe una amplia variedad de metodologías de síntesis, dentro de las cuales la más comúnmente utilizada es el método de inyección en caliente.En este trabajo se expone la síntesis de puntos cuánticos de CdSe llevada a cabo mediante una de las tantas variantes de este método.","palabras_clave":"PUNTO CUÁNTICO|SELENIURO DE CADMIO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39105,"idioma_id":4,"titulo":"Geochemistry, U-Pb SHRIMP zircon dating and Hf isotopes of the Gondwanan magmatism in NW Argentina: petrogenesis and geodynamic implications","resumen":"We have carried out zircon U-Pb SHRIMP dating and Hf isotope determinations as well as geochemical analyses on three plutonic units of Gondwanan magmatism that crop out in NW Argentina. Two episodes of different age and genesis have been identified. The older one includes gabbros and diorites (Río Grande Unit) of 267±3 Ma and granitoids (belonging to the Llullaillaco Unit) of 263±1 Ma (late Permian, Guadalupian); the parent magmas were generated in an intraplate environment and derived from an enriched mantle but were subsequently contaminated by crustal components. The younger rocks are granodiorites with arc signature (Chuculaqui Unit) and an age of 247±2 Ma (middle Triassic-Anisian). Hf isotope signature of the units indicates mantle sources as well as crustal components.Hf model ages obtained are consistent with the presence of crustal Mesoproterozoic (mainly Ectasian to Calymnian (TDM(c)=1.24 to 1.44 Ga-negative Hf (T)) and juvenile Cryogenian sources (TDM=0.65 to 0.79 Ga-positive &#603;Hf (T)), supporting the idea of a continuous, mostly Mesoproterozoic, basement under the Central Andes, as an extension of the Arequipa-Antofalla massif. The tectonic setting and age of the Gondwanan magmatism in NW Argentina allow to differentiate:a. Permian intra-plate magmatism developed under similar conditions to the upper section of the Choiyoi magmatism exposed in the Frontal Cordillera and San Rafael Block, Argentina; b. Triassic magmatism belonging to a poorly knownsubduction-related magmatic arc segment of mostly NS trend with evidence of porphyry type mineralization in Chile, allowing to extend this metallotect into Argentina.","palabras_clave":"GONDWANAN MAGMATISM|GEOCHEMISTRY|U-PB SHRIMP DATING|LU-HF ISOTOPE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39106,"idioma_id":4,"titulo":"Famatinanthus, a new Andean genus segregated from Aphyllocladus (Asteraceae)","resumen":"Famatinanthus, a new genus of Asteraceae (Mutisioideae, Onoserideae), is described and illustrated to accommodate one species that was previously placed in Aphyllocladus (A. decussatus), from the Andes of Argentina. The new genus is assigned to tribe Onoserideae based on its shrubby habit, solitary homogamous capitula, marginal florets with bilabiate corollas, disc floret corollas deeply 5-lobed, anthers with long pilose tails, short bifid style rounded at the apex and dorsally papillose, and 2-3-seriate heteromorphic pappus. Famatinanthus is similar to Aphyllocladus but it is easily distinguished by the leafy, decussate branches with opposite leaves, multistoried T-trichomes, cream corollas, apiculate anther apical appendages, short-pilose achenes, non-striate stems, secretory cavities absent, and pollen with a conspicuous mesoaperture and microechinate-rugulate exine. A key to the genera of Onoserideae is presented. Affinities of the new genus with other genera of the Mutisieae sensu lato are also discussed.","palabras_clave":"ARGENTINA|ASTERACEAE|LA RIOJA|SIERRA DE FAMATINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39107,"idioma_id":4,"titulo":"The Rhyacian El Cortijo suture zone: Aeromagnetic signature and insights for the geodynamic evolution of the southwestern Rio de la Plata craton, Argentina","resumen":"The amalgamation of the southern Río de la Plata craton involves two possibly coeval Rhyacian sutures associated with the Transamazonian orogeny, rather than a single one as previously envisaged, i.e. the El Cortijo suture zone and the Salado suture. We circumscribe the Tandilia terrane to the region between these two sutures.The El Cortijo suture zone runs along a roughly WNW oriented magnetic low aligned along thesouthern boundary of the Tandilia terrane, i.e. boundary between the Tandilia and Balcarce terranes. This extensive magnetic low, ca. 300 km long, and ca. 90 km wide, would be caused by demagnetization associated with shearing. At a more local scale, the trend of the El Cortijo suture zone often turns toward the EeW. At this scale, WNW trending tholeiitic dykes of Statherian age are seen to cut the Rhyacian El Cortijo suture zone. Spatially associated with the El Cortijo suture zone, there are small magnetic highs interpreted to be related to unexposed basic bodies of ophiolitic nature related to those forming part of the El Cortijo Formation.We envisage the pre-Neoproterozoic evolution of the Tandilia belt to have been initiated by theextension of Neoarchean (w2650 Ma) crust occurred during Siderian times (2500e2300 Ma), causing the separation between the Balcarce, Tandilia and Buenos Aires terranes, and the development of narrow oceans at both north and south sides of the Tandilia terrane, accompanied by w2300e2200 Ma sedimentation over transitional econtinental to oceanice crust, and arc magmatism developed in the Tandilia terrane. The island arc represented by the El Cortijo Formation was also developed at this time. At late Rhyacian times, it occurred in both the closure of the narrow oceans developed previously, the entrapment of the El Cortijo island arc, as well as anatectic magmatism in the Balcarce terrane.","palabras_clave":"El Cortijo Suture Zone|Rhyacian|Rio de la Plata Craton|Aeromagnetics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39108,"idioma_id":4,"titulo":"Evaluation of different PAMAM dendrimers as molecular vehicle of 1,2,4-triazine N-oxide derivative with potential antitumor activity","resumen":"Abstract The interaction between a 1,2,4-triazine N-oxide  derivative, that holds potential antitumor activity under  hypoxic conditions, and diverse polyamidoamine (PAMAM)  dendrimers were investigated with the purpose of  select the most appropriate macromolecule to act as  potential molecular carrier of this active compound. The  results shows that dendrimers with amine terminal groups  (PAMAM-AT G = 3) and dendrimers with carboxylate  terminal groups (PAMAM-CT G2.5 and G4.5) produces  triazine derivative hydrolysis, even in buffered medium,  and are not suitable as carriers. In contrast, dendrimers with  neutral end groups (PAMAM-OHT) shows stable association  with the active compound, making this dendrimer a  possible medium for triazine carriage.","palabras_clave":"Dendrimers PAMAM|Triazine N-oxide|Host-guest association|Antitumoral drug stability"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39109,"idioma_id":4,"titulo":"Four new species and eighteen lectotypifications of Larnax from Ecuador and Peru and a new synonym of Deprea orinocensis (Solanaceae: Solanoideae, Physalideae)","resumen":"Four new species of Larnax, L. macasiana, L. pumila, L. purpureocarpa, and L. toledoana, are described and illustrated and species conservation assessments presented. Eighteen lectotypifications of Peruvian Larnax: Larnax abra-patriciae, L. altomayoensis, L. bongaraensis, L. chotanae, L. dilloniana, L. kann-rasmusseniorum, L. longipedunculata, L. lutea, L. nieva, L. pedrazae, L. peruviana, L. pilosa, L. pomacochaense, L. purpurea, L. sagasteguii, L. sawyeriana, L. schjellerupiae, and L. vasquezii are proposed, mostly to replace material destroyed in a fire at HAO (Trujillo, Peru). A new synonym of Deprea orinocensis from Ecuador, Iochroma suffruticosum is also proposed and lectotypified based on an examination of original type material.","palabras_clave":"TAXONOMY|SOUTH AMERICA|SPECIES CONSERVATION ASSESSMENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39110,"idioma_id":5,"titulo":"ESTIMACIÓN DEL TAMAÑO MUESTRAL PARA ESTUDIOS DE VARIABILIDAD  MORFOLÓGICA IN SITU DE LIPPIA INTEGRIFOLIA (VERBENACEAE) EN EL  PARQUE NACIONAL TALAMPAYA, LA RIOJA (ARGENTINA)","resumen":"Lippia integrifolia - incayuyo - es un arbusto aromático y medicinal de interés económico cuya distribución abarca desde Bolivia hasta el noroeste y centro de Argentina. Presenta una amplia variabilidad entre individuos de la misma especie, la cual podría ser el resultado de la interacción con el ambiente y\/o estar determinada genéticamente. Sobre la base de esta variabilidad, estudios de caracterización y conservación son necesarios para posteriores evaluaciones agronómicas, mejoramiento genético, selección y reproducción de materiales con características deseables. El objetivo de este trabajo fue determinar, utilizando dos métodos de estimación, el número de individuos mínimo a relevar in situ que representen la variabilidad morfológica de una población de L. integrifolia, para futuros estudios de caracterización de la especie. A partir de un muestreo preliminar realizado en el Parque Nacional Talampaya en el que se registraron 11 caracteres morfométricos en L. integrifolia, se realizó una estimación paramétrica y una no parametrica del Tamaño Muestral Mínimo. Sobre la base de los caracteres morfométricos aquí evaluados se recomienda un tamaño de muestra mínimo de entre 35 a 40 ejemplares, determinado por los caracteres que mostraron mayor variabilidad, con el cual se garantizaría poder captar la variabilidad morfológica de los individuos.","palabras_clave":"LIPPIA INTEGRIFOLIA|CARACTERIZACION IN SITU|VARIACION INTRAESPECIFICA|TAMAÑO MUESTRAL MINIMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39111,"idioma_id":4,"titulo":"Morphological Analysis of the Flippers in the Franciscana Dolphin, Pontoporia blainvillei, Applying X-Ray Technique","resumen":"Pectoral flippers of cetaceans function to provide stability and  maneuverability during locomotion. Directional asymmetry (DA) is a common  feature among odontocete cetaceans, as well as sexual dimorphism  (SD). For the first time DA, allometry, physical maturity, and SD of the  flipper skeleton?by X-ray technique?of Pontoporia blainvillei were analyzed. The number of carpals, metacarpals, phalanges, and morphometric  characters from the humerus, radius, ulna, and digit two were studied in  franciscana dolphins from Buenos Aires, Argentina. The number of visible  epiphyses and their degree of fusion at the proximal and distal ends of  the humerus, radius, and ulna were also analyzed. The flipper skeleton  was symmetrical, showing a negative allometric trend, with similar  growth patterns in both sexes with the exception of the width of the  radius (P0.01). SD was found on the number of phalanges of digit two  (P0.01), ulna and digit two lengths. Females showed a higher relative  ulna length and shorter relative digit two length, and the opposite  occurred in males (P0.01). Epiphyseal fusion pattern proved to be a  tool to determine dolphin?s age; franciscana dolphins with a mature flipper were, at least, four years old. This study indicates that the flippers of franciscana dolphins are symmetrical; both sexes show a negative allometric trend; SD is observed in radius, ulna, and digit two; and flipper skeleton allows determine the age class of the dolphins. Anat Rec, 00:000?000, 2014.","palabras_clave":"DIRECTIONAL ASYMMETRY|ALLOMETRY|SEXUAL DIMORPHISM|APPENDICULAR SKELETON"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39112,"idioma_id":4,"titulo":"Photodynamic properties and photoinactivation of Candida albicans mediated by brominated derivatives of triarylmethane and phenothiazinium dyes","resumen":"The photodynamic activity of brominated derivatives of New Fuchsin and AzureB was studied in solution and in cell suspensions of Candida albicans. The spectroscopic andphotodynamic properties of these photosensitizers were compared with those of Crystal Vio-let and Azure B, which represent active photosensitizer related to each family of compounds.Triarylmethane derivatives absorb intensely with a band centered at &#8764;570 nm, while the phe-nothiazinium dyes at &#8764;650 nm. Photooxidation of 9,10-dimethylanthracene was observed usingphenothiazinium compounds indicating the formation of singlet molecular oxygen, while it wasnot detected using triarylmethane agents. However, triarylmethane dyes were able to photoox-idize L-tryptophan. In yeast cell suspensions, the photosensitized inactivation of C. albicansincreases with photosensitizer concentration, causing a &#8764;5 log decrease of cell survival, whenthe cultures are treated with 20 M of Crystal Violet and irradiated for 60 min. Under these con-ditions, the photodynamic activity of 50 M Azure B induced a &#8764;3 log decrease of cell survival.Studies of photodynamic action mechanism indicated that photoinactivation of C. albicans cellsinduced by triarylmethane compounds involves mainly type I photoprocess. Although, phenoth-iazinium derivatives produce singlet molecular oxygen, a contribution of other reactive oxygenspecies cannot be discarded in the photoinactivation of C. albicans.","palabras_clave":"Candida albicans"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39113,"idioma_id":4,"titulo":"Characteristics of judicialization of health in relation to drugs","resumen":"The aim of this article is to characterize the procedure of judicialization to request drugs in a health plan for public employees in the Province of Santa Fe, corresponding to the south area, which coexists with other two subareas, public and private. These administrative and\/or judicial procedures add to the idea that the 'judicialization of health' obtains provision of drugs which are not considered by the health system. This research employs a qualitative methodology with analysis of the content of drugs claims which were filed in appeals for protection by members. The sample includes 43 claims, and it was taken from a total of 209 claims for protection filed at the health plan´s Legal Department during 2007-2013. Most of the claims for protection are related to high cost drugs. In most of the cases, the plaintiff obtains what they claim. As regards arguments in favor of the plaintiffs, some statements endorse forensic experts´ reports, others highlight the need and urgency of having the requested drug available, and still others present the drug as orphan, unique or novel. In those cases which were favorable to the health plan, similar reasons were observed between the expert witnesses and the defendant party.","palabras_clave":"Judicialización|Medicalización|Pensamiento Complejo|Derecho de la Salud"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39114,"idioma_id":4,"titulo":"Determination of fluoroquinolones in bovine milk samples using a pipette-tip SPE step based on multiwalled carbon nanotubes prior to CE separation","resumen":"A simple CE-UV method was developed for the simultaneous determination of  ciprofloxacin, norfloxacin, and ofloxacin in milk samples. The optimum separation was obtained  using a 20mM ammonium dihydrogenphosphate solution with 2mMcetyltrimethylammonium  bromide at pH 3.0 as the BGE. Satisfactory resolution for structurally very  similar analytes, like norfloxacin and ciprofloxacin, was achieved without including any  organic solvent. Milk samples were prepared using a simple\/extraction procedure based on  acidic protein precipitation followed by an SPE step using only 5 mg of multiwalled carbon  nanotubes as the sorbent material. The LODs for the three compounds were between 7.5  and 11.6 ug\/L and the RSDs for the peak areas were between 2.6 and 4.9%. The complete  method was applied to spiked real milk samples with satisfactory recoveries for all analytes  (84-106%)","palabras_clave":"CE |Fluoroquinolones |Multiwalled carbon nanotubes |SPE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39115,"idioma_id":4,"titulo":"Response of mussel population to sewage-impact in rocky-stony shore","resumen":"In Mar del Plata, a rocky-stony-shore near a sewage discharge develops a community of Brachidontes rodriguezii. Samples along a gradient of organic contamination and a control site were selected randomly for studies of density, proportion of  adults\/seeds, biomass, and length, width and height of mussels. Density of adults, seeds and biomass were significantly lowest nearest to outfall increasing to control sites. In spite of the high mortality of seeds, the surviving mussel seems to have better condition near the sewage outfall. Unexpected allometric results showed greatest values of length, width and height near the outfall rather than in control site. After summer, Biomass and size of mussel were lower as results of increasing sewage discharge.","palabras_clave":"assessment|alometry|bivalves |intertidal"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39116,"idioma_id":4,"titulo":"Is it possible to determine physiological quality and best conditions of storage of soybean seeds by isothermal calorimetry?","resumen":"Seeds of soybean, cv. DM5.8RR of two different physiological qualities were germinated and monitoredby isothermal calorimetry and imbibition methods. Also, seeds stored at 25 &#9702;C under different vaporpressures were analyzed. Results showed that those seeds with lower physiological quality, lot 1 (germinationpower of 62%) had a much higher speed of water uptake than seeds with a germination powerof 93%, lot 3. Thus, endothermic peaks could be observed in the specific thermal power time curves ofgermination of seeds of lot 1 which were related to anoxia. Seeds of lot 3 with different initial watercontent, iWC, showed three phases of imbibition where the third also involved metabolism. Apparently,when the enthalpy change value of water?seed interaction of the three phases is similar, roots protrudewith vigor. Such was the case for soybean seeds with 0.084 and 0.101 g g&#8722;1 iWC.","palabras_clave":"ISOTHERMAL CALORIMETRY|GLYCINE MAX|SEED GERMINATION|PHYSIOLOGICAL QUALITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39117,"idioma_id":4,"titulo":"Modelling proton and metal binding to humic substances with the NICA-EPN model","resumen":"The mathematical modelling of metal cation-natural organic matter interactions is a fundamental tool in predicting the state and fate of pollutants in the environment. In this work, the binding of protons and metal cations to humic substances is modelled applying the Elastic Polyelectrolyte Network (EPN) electrostatic model with the Non Ideal Competitive Adsorption (NICA) isotherm as the intrinsic part (NICA-EPN model). Literature data of proton and metal binding to humic substances at different pH and ionic strength values are analysed, discussing in depth the model predictions. The NICA-EPN model is found to describe well these phenomena. The electrostatic contribution to the Gibbs free energy of adsorbate-humic interaction in the EPN model is lower than that predicted by the Donnan phase model; the intrinsic mean binding constants for protons and metal cations are generally higher, closer to independent estimations and to the range of acid-base and complexation equilibrium values for common carboxylic acids. The results for metal cations are consistent with recent literature findings. The model predicts shrinking of the humic particles with increased metal binding, as a consequence of net charge decrease.","palabras_clave":"Humic substances|Trace metals|Complexation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39118,"idioma_id":4,"titulo":"Synthesis and cholinesterase inhibition of cativic acid derivatives","resumen":"Alzheimer´s disease (AD) is a neurodegenerative disorder associated with memory impairment and cognitive deficit. Most of the drugs currently available for the treatment of AD are acetylcholinesterase (AChE) inhibitors. In a preliminary study, significant AChE inhibition was observed for the ethanolic extract of Grindelia ventanensis (IC50 = 0.79 mg\/mL). This result prompted us to isolate the active constituent, a normal labdane diterpenoid identified as 17-hydroxycativic acid (1), through a bioassay guided fractionation. Taking into account that 1 showed moderate inhibition of AChE (IC50 = 21.1 µM), selectivity over butyrylcholinesterase (BChE) (IC50 = 171.1 µM) and that it was easily obtained from the plant extract in a very good yield (0.15% w\/w), we decided to prepare semisynthetic derivatives of this natural diterpenoid through simple structural modifications. A set of twenty new cativic acid derivatives (3-6) was prepared from 1 through transformations on the carboxylic group at C-15, introducing a C2-C6 linker and a tertiary amine group. They were tested for their inhibitory activity against AChE and BChE and some structure-activity relationships were outlined. The most active derivative was compound 3c, with an IC50 value of 3.2 µM for AChE. Enzyme kinetic studies and docking modeling revealed that this inhibitor targeted both the catalytic active site and the peripheral anionic site of this enzyme. Furthermore, 3c showed significant inhibition of AChE activity in SH-SY5Y human neuroblastoma cells, and was non-cytotoxic.","palabras_clave":"Alzheimers disease|cholinesterase inhibitors|diterpenoids|labdane|SH-SY5Y neuroblastoma cells|molecular modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39119,"idioma_id":4,"titulo":"Zirconia-Supported Copper and KNO3 Catalysts for Diesel Soot Combustion. Deactivation by Hydrotreatment and SO2","resumen":"In this study, the sulfur tolerance and hydrothermal stability of Cu-KNO3\/ZrO2 catalysts in catalytic diesel soot oxidation were investigated. Supported alkaline nitrate catalysts have shown excellent activity for soot oxidation in the presence of O2 or NO\/O2. High-temperature water vapor treatments do not affect the  catalytic activity, suggesting a good hydrothermal stability of the catalysts. Treatments performed at high SO2 concentration lead to a partial deactivation ofthe catalysts for the combustion reaction in the presence of O2. The presence of copper improves the sulfur tolerance of the KNO3\/ZrO2 catalyst for the combustion of soot in the presence of NOx. NO\/O2 present in the feed flow of the reactor can regenerate in situ nitrate anions that provide the redox cycles required for the reaction.","palabras_clave":"DIESEL SOOT|COMBUSTION|HYDROTHERMAL STABILITY|SO2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39120,"idioma_id":4,"titulo":"Antibacterial, Antifungal, Phytotoxic, and Genotoxic Properties of Two Complexes of AgI with Sulfachloropyridazine (SCP): X-ray Diffraction of [Ag(SCP)]n","resumen":"We report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN&#8722; ligands (Ag?SCP?SCN), the other of which is homoleptic (Ag?SCP); furthermore, the crystal structure of the homoleptic complex is disclosed. The heterocyclic N atom nearest to the Cl atom and the Nsulfonamide atom could be coordination sites for the silver ion in the Ag?SCP?SCN complex. The Ag?SCP complex is a polymeric compound with metal?metal bonds, and the heterocyclic and sulfonamide N atoms are points of coordination for AgI. Both complexes showed activity against all the tested bacteria, and in the cases of Escherichia coli and Pseudomonas aeruginosa, the action was better than that of SCP. In all cases, both silver?SCP complexes showed better antifungal activity than SCP, which was inactive against the tested fungi. Notably, the activity against P. aeruginosa, a nosocomial multidrug-resistant pathogen, was better than that of the reference antibiotic cefotaxim. Both silver?sulfa complexes displayed moderate activity against the tested yeast, especially for C. neoformans, which is an important fact considering the incidence of cryptococcosis, mainly in immune-deficient patients. No chromosomal aberrations were observed with the Allium cepa test, which is auspicious for further study of these complexes as potential drugs.","palabras_clave":"ALLIUM TEST|ANTIBACTERIAL AGENTS|ANTIFUNGAL AGENTS|SILVER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39121,"idioma_id":4,"titulo":"Vulnerability of Patagonian planktonic copepods to fluctuations in temperature and UVR","resumen":"The aim of this investigation is to address the impact of fluctuations in temperature andultraviolet radiation (UVR) on three species of South American copepods, Boeckellaantiqua, B. gracilis and B. brevicaudata. Due to their restricted distribution to highlatitude lakes of South America and to mountain lakes in the Andes, these copepodsare considered cold stenotherm. The forecasted scenarios for climate change inSouthern South America anticipate raising temperature and UVR levels with thepotential to impact different ecosystems, and particularly, high altitude and latitudelakes and their cold adapted biota, such as those in Patagonia. Laboratoryexperiments were set up to analyse: (i) the effect of temperature and, (ii) the combinedeffect of temperature (5, 8, 12, 16, 20°C) and the dose of UV-B radiation (61, 194 and324 J m-2) on copepod mortality. Experiments consisted of 10 day and 2 dayincubations, respectively. The results showed that temperature is a limiting factor for B.brevicaudata that did not survive above 12°C. B. antiqua and B. gracilis withstood thetemperature range; however, their mortality was higher between 12°C and 16°C. Thesecond set of experiments showed that the survivorship of the three copepod speciesdepend on the UV-B dose applied, with higher mortality at the highest dose. Thetreatments combining the higher temperatures of the range and the highest UV-B doseincreased copepod mortality. Overall, at least one Boeckella species showed an acutesensitivity to increasing temperature, and the three species studied withstood theexposure to UV-B. The tolerance levels observed in this study reflect the specificadaptation of the copepods to conditions ranging from temperate to cold, and the highexposure to elevated solar radiation prevailing in their natural environments.","palabras_clave":"Planktonic copepods|Boeckella|temperature|UV"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39122,"idioma_id":4,"titulo":"13C and 15N variability in modern guanaco (Lama guanicoe) assemblages in southern Patagonia: implications for zooarchaeological studies","resumen":"We study the isotopic variability of modern social groups of guanacos (Lama guanicoe) and discuss the implications of these results for the analysis of archaeofaunas from archaeological sites of Patagonia. The  aim of this work is to evaluate whether the study of the isotope composition of carbon and nitrogen from collagen (d13C and d15N) is a methodology that allows the discussion of hunting strategies ? individual versus mass ? carried out by human populations in this particular case of the guanaco from southern Patagonia. Samples come from five modern assemblages of guanacos located in the west margin of the Cardiel Lake  and are the result of a catastrophic mortality episode produced by winter stress. The isotopic variability of these samples is compared with that of a mesoregional attritional assemblage built from multiple sites and  chronologies. The results indicate, in the first place, that there is no differentiation between males and females, second, that the offspring show no increase of signals when compared to the other age  categories and finally, juveniles recorded the lowest d15N values. In relation to the main purpose of this research, measurements of variability from modern assemblages and the attritional groups have been  compared. The three assemblages with lower variability are modern ones. However, the two remaining modern assemblages record a variability higher than or equal to the attritional groups. Thus, for southern Patagonian guanacos, the hypothesis that proposes that the isotopic variability of a herd would be lower than the one obtained from multiple populations and different hunting events is rejected. Finally, we analyze the possible causes for these results together with situations in which d13C and d15N can be used in the study of the guanaco hunting strategies in southern Patagonia.","palabras_clave":"Guanaco|Holocene|Patagonia|Hunter-Gatherer|Carbon|Nitrogen|Zooarchaeology|Collagen"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39123,"idioma_id":4,"titulo":"Applications of Stable Isotope Analysis in Zooarchaeology: An Introduction","resumen":"This special volume brings together works that present cases of studies that combine analysis of stable isotopes and zooarchaeology in different areas of Chile and Argentina, with special emphasis on the latter.These analyses were conducted in order to examine paleoecological conditions and interactions between humans and animal resources in different spatial and temporal contexts. In this introduction, we examinethree ways in which stable isotopes have been applied in zooarcheology: (i) past animal-human relations, (ii) stable isotopes and zooarchaeology in conservation biology, and (iii) species biogeography, climate, and environment. The implications of the results of each of the papers in this volume stress that this type of study is a fruitful and promising line of research as it expands the thematic spectrum investigated, testsarchaeological hypothesis, explores new lines of analysis, and enriches the interpretations about the past.","palabras_clave":"zooarchaeology|stable isotopes|human-animal relation|conservation biology|biogeography"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39124,"idioma_id":4,"titulo":"A Monoallelic Deletion of the TcCRT Gene Increases the Attenuation of a Cultured Trypanosoma cruzi Strain, Protecting Against an in Vivo Virulent Challenge","resumen":"Trypanosoma cruzi calreticulin (TcCRT) can hijack complement C1, mannan-binding lectin and ficolins from serum thus inhibiting the classical and lectin complement pathway activation respectively. To understand the in vivo biological functions of TcCRT in T. cruzi we generated a clonal cell line lacking one TcCRT allele (TcCRT+\/-) and another clone overexpressing it (TcCRT+). Both clones were derived from the TCC T. cruzi strain. As expected, TcCRT+\/- epimastigotes showed impairment on TcCRT synthesis, whereas TcCRT+ ones showed increased protein levels. In correlation to this, monoallelic mutant parasites were significantly susceptible to killing by the complement machinery. On the contrary, TcCRT+ parasites showed higher levels of resistance to killing mediate by the classical and lectin but not the alternative pathway. The involvement of surface TcCRT in depleting C1 was demonstrated through restoration of serum killing activity by addition of exogenous C1. In axenic cultures, a reduced propagation rate of TcCRT+\/- parasites was observed. Moreover, TcCRT+\/- parasites presented a reduced rate of differentiation in in vitro assays. As shown by down- or upregulation of TcCRT expression this gene seems to play a major role in providing T. cruzi with the ability to resist complement system.","palabras_clave":"KNOCK-OUT|CALRETICULIN|INFECTIVITY|ATTENUATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39125,"idioma_id":4,"titulo":"Burrowing behavior of an infaunal clam species after siphon nipping","resumen":"Burial depth plays an important role in the life of many infaunal clam species. For these organisms, the most effective defense against predation is to bury into the sediment, which hinder the detection and manipulation of predators. In laboratory conditions, we examined Mesodesma mactroides normal burial depth recovery after two artificial siphon nipping levels (1 cm and 5 cm). The 1 cm siphon nipping experiment was repeated in winter and spring to evaluate if burial depth recovery differs between seasons. The data of normal burial depth (uncut clams) were fitted using linear mixed-effects models, and the data of burial depth recovery (cut clams) were analyzed using non-linear mixed-effects models. In the latter case, three candidate models were tested with each depth data set to explain the normal burial depth recovery at the two cut levels and seasons. The logistic model best explained the recovery of normal burial depth after siphon nipping in M. mactroides. The normal burial depth (uncut clams) did not vary among the studied seasons (winter and spring). On the other hand, there was a synergic effect between seasonality and siphon nipping on clam normal burial depth recovery, being faster in spring than in winter. Lastly, the clams with 5 cm siphon nipping had a delay in recovering the normal burial depth in comparison to clams with 1 cm siphon nipping. Thus, our results show that the temporal window of lethal predation risk could increase according to the level of siphon nipping and the season in which occurs.","palabras_clave":"Burial depth|Mesodesma mactroides|Soft clam|Sublethal predation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39126,"idioma_id":4,"titulo":"A simple model to predict phenology in malting barley based on cultivar thermo-photoperiodic response","resumen":"In the Pampean region of Argentina, farming systems are based on intensive land use, wheat\/soybeandouble cropping being a key component of these agricultural systems. However, during the last yearsfarmers have been replacing wheat for barley due to its earlier maturity date, reducing yield penalizationin soybean as a consequence of delays in its sowing date, and improving the economic profits of the double cropping system. To maximize the benefits of barley\/soybean double cropping system, the propertiming of key barley ontogenic stages should be easily identifiable by farmers. The objectives of the present study were to (i) characterize crop phenology through thermo-photoperiod models in response to different sowing dates, (ii) use the algorithms calculated in point (i) to generate a simple model forpredicting phenology, using historical climatic series, and (iii) validate the model with independent data.Barley cultivars used in the present study did not show vernalization requirements. Variations in phenology, measured in thermal time, were mainly associated with variations in photoperiod sensitivity duringthe emergence-heading phase. Significant differences in photoperiodic sensitivity, from 65Cd h1(Scarlett) to344Cd h1(Q. Ayelen), were observed among cultivars. However, cultivars did not showsignificant differences in critical photoperiod or intrinsic earliness. The slope of the relationship betweenheading time and date of emergence, calculated from the algorithms used to build the model, based onthermo-photoperiodic response, varied between locations and cultivars. When the model was testedwith an independent data set, predictions for the sowing-flowering phase showed a root mean squareerror lower than 4% (similar to that observed using more complex models). The algorithms used in themodel were masked into a friendly frame and outputs were shown in a simple and attractive mannerfor users. The model was uploaded to the web site of the University of Buenos Aires to be used bystudents, advisors, professionals and farmers barley","palabras_clave":"Phenology|barley"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39127,"idioma_id":4,"titulo":"Tetrapod and invertebrate trace fossils from eolian deposits of the lower Permian of central-western Argentina","resumen":"Abundant tetrapod footprints are described from the Early Permian Yacimiento Los Reyunos Formation including bothcollected and in situ specimens. The slabs come from several quarries at the Sierra Pintada and Sierra de las Pen?as area,south-west of Mendoza, Argentina. The trace fossil assemblage, which constitutes one of the oldest known from Gondwana,comprises excellent-preserved tetrapod tracks (Chelichnus duncani, Chelichnus gigas and ?pear-like? footprints) andinvertebrate simple sub-horizontal (Palaeophycus tubularis) and vertical (Skolithos isp.) burrows formed in a aeolian dunefield. The analysis of the tetrapod track producers indicates the presence of at least three different taxa of sprawling to semierecttherapsids, thus suggesting the presence of members of this clade, or closest relatives, in the Early Permian of southernGondwana. Moreover, a series of measurements and simple indexes were developed to estimate body proportions andlocomotion styles of the putative trackmakers. The new assemblage, analysed in the context of other known Permianassemblages from Pangea, is one the few known in Gondwana to be present in an aeolian environment. The evaluation of theassemblage, in the light of aeolian ichnofacies (Chelichnus, Octopodichnus and Entradichnus), shows that it has commonelements with the Chelichnus and Entradichnus ichnofacies.","palabras_clave":"Chelichnus|Therapsida|Yacimiento Los Reyunos Foemation|locomotion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39128,"idioma_id":4,"titulo":"Effect of carbon nanotubes purification in the performance of a negative electrode of a Ni\/MH battery","resumen":"Multiwall carbon nanotubes (MWCNT) with a diameter of 30-50 nm was added to the negative electrode of a Ni-MH battery in order to study the effect of its purification treatment on the electrochemical performance. Three different reflux assisted digestion methods were analyzed. MWCNT were structural characterized before and after purifications by means of different techniques such as HRTEM, EDS, SEM, XRD and FTIR. Subsequently they were incorporated into the working electrode to evaluate the electrochemical performance by charge\/discharge cycling and rate capability.","palabras_clave":"Carbon nanotubes|Metal hydride|Ni\/MH battery"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39129,"idioma_id":4,"titulo":"Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy","resumen":"Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40&#8201;&#956;g\/mL onwards and at least after 3&#8201;h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.","palabras_clave":"COLLAEA ARGENTINA |PHOTODYNAMIC THERAPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39130,"idioma_id":4,"titulo":"Photodynamic inactivation of Gram-positive bacteria employing natural resources","resumen":"The aim of this paper was to investigate a collection of plant extracts from Argentina as a source of new natural photosensitizers (PS) to be used in Photodynamic Inactivation (PDI) of bacteria. A collection of plants were screened for phototoxicity upon the Gram-positive species Staphylococcus epidermidis. Three extracts turned out to be photoactive: Solanum verbascifolium &#64258;ower, Tecoma stans &#64258;ower and Cissus verticillata root. Upon exposure to a light dose of 55 J\/cm , they induced 4, 2 and 3 logs decrease in bacterial survival, respectively. Photochemical characterisation of S. verbascifolium extract was carried out. PDI reaction was dependent mainly on singlet oxygen and to a lesser extent, on hydroxyl radicals, through type II and I reactions. Pho-todegradation experiments revealed that the active principle of the extract was not particularly photola-bile. It is noticeable that S. verbascifolium ?PDI was more ef&#64257;cient under sunlight as compared to arti&#64257;cial light (total eradication vs. 4 logs decrease upon 120 min of sunlight). The balance between oxidant and antioxidant compounds is likely to be masking or unmasking potential PS of plant extracts, but employing the crude extract, the level of photoactivity of S. verbascifolium is similar to some arti&#64257;cial PS upon exposure to sunlight, demonstrating that natural resources can be employed in PDI of bacteria.","palabras_clave":"BACTERIA|NATURAL PRODUCTS|PHOTODYNAMIC THERAPY|PHOTOINACTIVATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39131,"idioma_id":4,"titulo":"Redescription of Bonatitan reigi (Sauropoda: Titanosauria), from the Campanian-Maastrichtian of the Río Negro Province (Argentina)","resumen":"The titanosaur sauropod Bonatitan reigi is redescribed. The material collected, originally interpreted as pertaining to two different individuals, is reorganised in five individuals, and the original type specimen is separated into three different individuals. One of the braincases is designated as a new type specimen. Some materials are described by the first time (sacral ribs, distal caudal, chevrons, metacarpals, astragalus and metatarsals), others reinterpreted as different bones (?ulna? and ?radius?). The diagnosis of B. reigi is emended, removing some of the original characters (longitudinal groovelocated on the suture between the parietals that continues posteriorly over the supraoccipital to the foramen magnum) and adding some new (small paired pits on the frontals and posterior ridge of the metacarpal IV). The phylogenetic analysis does not support B. reigi as a member of the Saltasaurinae, but rather as a basal member of a broad clade of sauropods that in turn is recovered as the sister group of the Saltasauridae.","palabras_clave":"Sauropoda|Titanosauria|Bonatitan|Upper Cretaceous"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39132,"idioma_id":4,"titulo":"A Diplodocid Sauropod Survivor from the Early Cretaceous of South America","resumen":"Diplodocids are by far the most emblematic sauropod dinosaurs. They are part of Diplodocoidea, a vast clade whose other  members are well-known from Jurassic and Cretaceous strata in Africa, Europe, North and South America. However,  Diplodocids were never certainly recognized from the Cretaceous or in any other southern land mass besides Africa. Here  we report a new sauropod, Leikupal laticauda gen. et sp. nov., from the early Lower Cretaceous (Bajada Colorada Formation)  of Neuque  ´  n Province, Patagonia, Argentina. This taxon differs from any other sauropod by the presence of anterior caudal  transverse process extremely developed with lateroventral expansions reinforced by robust dorsal and ventral bars, very  robust centroprezygapophyseal lamina in anterior caudal vertebra and paired pneumatic fossae on the postzygapophyses  in anterior-most caudal vertebra. The phylogenetic analyses support its position not only within Diplodocidae but also as a  member of Diplodocinae, clustering together with the African form Tornieria, pushing the origin of Diplodocoidea to the  Middle Jurassic or even earlier. The new discovery represents the first record of a diplodocid for South America and the  stratigraphically youngest record of this clade anywhere.","palabras_clave":"Lower Cretaceous|vertebrates|biogeography|extinction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39133,"idioma_id":4,"titulo":"Reacquisition, reinstatement and renewal of a conditioned taste aversion in preweanling rats","resumen":"Pavlovian extinction is defined as a reduction of the conditioned  response (CR) as a consequence of repeated and nonreinforced resentations of the conditioned stimulus (CS). This phenomenon has been explained through two nonexclusive associative hypotheses. One of them proposes that the CS?unconditioned stimulus (US) association is weakened during extinction, while the second one explains extinction by the formation of a new inhibitory association between the CS, and the US (CS?noUS) which competes with the excitatory one acquired at conditioning (CS?US). Research supporting this second hypothesis is based on the demonstration that the CR can be recovered after extinction. However, in preweanling rats, renewal, and reinstatement treatments have failed to recover a conditioned fear response, suggesting that extinction during this ontogenetic period may involve erasure of the CS?US association. The goal of the present study was to explore whether this conclusion can be extended to the extinction of a conditioned taste aversion by evaluating  infant rats in three different procedures (reacquisition, ABA renewal, and reinstatement). The results are consistent with the idea that extinction of a taste aversive memory during infancy involves relearning about the relationship between the CS and the US, with the initial CS?US association remaining relatively intact. Extinction of a taste aversive memory and a fear memory may involve different biological mechanisms during infancy. The conclusion that the only psychological mechanism for extinction during infancy is unlearning should be confined to a particular type of memory.","palabras_clave":"EXTINCTION|INFANT|RAT|TASTE AVERSION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39134,"idioma_id":4,"titulo":"Comparison of algorithms to infer genetic population structure from unlinked molecular markers","resumen":"Identifying population genetic  structure (PGS) is crucial  for breeding and  conservation. Several clustering algorithms are available to identify the underlying PGS to be used with genetic data of maize genotypes. In this work, six methods to identify PGS from unlinked molecular marker data were compared using simulated and  experimental data  consisting of multilocus-biallelic genotypes. Datasets  were  delineated under  different  biological  scenarios characterized by three  levels of genetic  divergence among  populations (low, medium, and high FST) and two numbers of sub-populations (K&#8202;=&#8202;3 and K&#8202;=&#8202;5). The relative  performance of hierarchical and  non-hierarchical clustering, as well as model-based clustering (STRUCTURE) and  clustering  from neural networks  (SOM-RP-Q). We use the clustering error rate  of genotypes into discrete  sub- populations as comparison criterion. In scenarios with great level of divergence among genotype groups  all methods performed well. With moderate level of genetic divergence (FST&#8202;=&#8202;0.2), the algorithms SOM-RP-Q and STRUCTURE performed better  than  hierarchical and non-hierarchical clustering. In all simulated scenarios with low genetic divergence and in the experimental SNP maize panel (largely unlinked), SOM-RP-Q achieved the lowest clustering error rate. The SOM algorithm used here is more effective than other evaluated methods for sparse unlinked genetic data.","palabras_clave":"cluster analysis|plant breading|self organizing maps"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39135,"idioma_id":4,"titulo":"Patterns of asymmetry in body traits and genitalia in two distant populations of a Neotropical scorpion","resumen":"The ability of a genotype to control the stable development of a phenotype underdifferent environmental conditions may explain the level of developmentalinstability. An indicator to developmental instability is Fluctuating Asymmetry.Traits under pressures of sexual selection exhibit greater values of asymmetry thatothers. These traits have more physiological requirements during morphogenesisand a more complex development. The aims of this work are to analyze asymmetry patterns of genitalic and somatic traits in the scorpion Bothriurus bonariensis(Bothriuridae) and to compare these values between central and peripheral populations of its distribution. We observed that types of asymmetry in genitalic traitsdiffered in both populations. Also, traits of the hemispermatophores (two halvesthat constitute the spermatophore) showed the highest levels of fluctuating asymmetry, particularly in those characteristics with important role for inseminationsuccess. This work offers fundamental baseline knowledge for further worksfocused on asymmetry of genitalia and mating success in scorpions","palabras_clave":"Developmental instability |Arachnids|Bothriurus bonariensis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39136,"idioma_id":4,"titulo":"Redox and complexation chemistry of the CrVI\/Cr V-d-glucaric acid system","resumen":"When an excess of uronic acid over CrVI is used, the oxidation of D-glucaric acid (Glucar) by CrVI yields D-arabinaric acid, CO2 and CrIII-Glucar complex as final redox products. The redox reaction involves theformation of intermediate CrIV and CrV species. The reaction rate increases with [H+] and [substrate]. Theexperimental results indicated that CrIV and CrV are very reactive intermediates since their disappearancerates are much faster than CrVI. CrIV and CrV intermediates are involved in fast steps and do not accumulatein the redox reaction of the mixture CrVI?Glucar. Kinetic studies show that the redox reactionbetween Glucar and CrVI proceeds through a mechanism combining one- and two-electron pathways:CrVI &#8594; CrIV &#8594; CrII and CrVI &#8594; CrIV &#8594; CrIII. After the redox reaction, results show a slow hydrolysis of theCrIII-Glucar complex into [Cr(OH2)6]3+. The proposed mechanism is supported by the observation of freeradicals, CrO22+ (superoxo-CrIII ion) and oxo-CrV-Glucar species as reaction intermediates. The continuous-wave electron paramagnetic resonance, CW-EPR, spectra show that five-coordinate oxo-CrV bischelatesare formed at pH &#8804; 4 with the aldaric acid bound to oxo-CrV through the carboxylate and the &#945;-OHgroup. A different oxo-CrV species with Glucar was detected at pH 6.0. The high giso value for the lastspecies suggests a mixed coordination species, a five-coordinated oxo-CrV bischelate with one moleculeof Glucar acting as a bi-dentate ligand, using the 2-hydroxycarboxylate group, and a second molecule ofGlucar with any vic-diolate sites. At pH 7.5 only a very weak EPR signal was observed, which may point toinstability of these complexes. This behaviour contrasts with oxo-CrV-uronic species, and must thus berelated to the Glucar acyclic structure. In vitro, our studies on the chemistry of oxo-CrV-Glucar complexescan provide information on the nature of the species that are likely to be stabilized in vivo.","palabras_clave":"CHROMIUM|KINETIC|GLUCARIC|EPR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39137,"idioma_id":4,"titulo":"The role of sigmodontine rodents as sylvatic hosts of Trypanosoma cruzi in the Argentinean Chaco","resumen":"The role of rodents in the sylvatic transmission of Trypanosoma cruzi has seldom been investigated usingparasitological and molecular methods. We assessed the occurrence of T. cruzi in wild small rodents fromPampa del Indio, in the Argentinean Chaco, and identified the taxonomic status of positive rodents bysequencing a fragment of cytochrome b gene (cytb) and performing BLAST searches and phylogeneticanalyses. A total of 176 Sigmodontinae rodents was captured in six surveys using 5425 trap-nights ina wide range of sylvatic habitats between 2009 and 2011. Host infection was determined by xenodiagnosisand by polymerase chain reaction amplification of the hyper-variable region of kinetoplast DNAminicircles of T. cruzi (kDNA-PCR) from blood samples. None of the 176 rodents examined was xenodiagnosis-positive. The prevalence of infection determined by kDNA-PCR from blood samples was 16.2%(95% confidence interval, 10.1?21.9%). Half of the infections detected by kDNA-PCR were confirmed bynuclear satellite DNA-PCR or by kDNA-PCR of the rectal contents of xenodiagnostic bugs. The 24 positivespecimens were assigned to eight species, providing the first records of T. cruzi in Akodon montensis,Akodon toba, Graomys chacoensis, and Oligoryzomys chacoensis. The occurrence of T. cruzi infection inOligoryzomys nigripes, Calomys callosus, Necromys lasiurus and Oecomys sp. (most probably Oecomysmamorae) from the Gran Chaco is also reported for the first time. Although sigmodontine rodents werefrequently infected, the intensity of bug rectal infection with T. cruzi was below the detection limit ofxenodiagnosis (subpatent infectiousness to bugs), indicating they had a low reservoir host competence.","palabras_clave":"Trypanosoma cruzi|sigmodontine rodents|parasitological and molecular diagnosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39138,"idioma_id":5,"titulo":"Dieta del Aguilucho Común (Geranoaetus polyosoma) en pastizales costeros y zonas periurbanas de la Región Pampeana","resumen":"Se estudió la dieta del Aguilucho Común (Geranoaetus polyosoma) durante el período no reproductivo en dos áreas contrastantes, un pastizal natural y una zona periurbana ubicadas en el sudeste de la Región Pampeana (Argentina), con el objetivo de evaluar si los hábitos tróficos de esta rapaz cambian de acuerdo al ambiente. La dieta del Aguilucho Común estuvo compuesta exclusivamente por micromamíferos en ambos sitios, aunque los ítem presa consumidos difirieron entre hábitats. El  ratón  de  campo  (Akodon  azarae)  fue  la  presa  dominante  en  pastizales  naturales,  mientras  que  el  tuco-tuco  (Ctenomys talarum) fue la presa principal en zonas periurbanas. El Aguilucho Común realizó un alto consumo de roedores grandes en pastizales (83,3% menores a 30 g de peso promedio) en comparación con zonas periurbanas (61,5% mayores a 90 g de peso promedio). Los resultados evidenciarían la plasticidad de esta rapaz a cambiar su comportamiento alimentario dependiendo de las condiciones locales.","palabras_clave":"AGUILUCHO COMÚN|DIETA|PASTIZAL NATURAL|ZONA PERIURBANA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39139,"idioma_id":4,"titulo":"Social networks and ornithology studies: an innovative method for rapidly accessing data on conspicuous bird species","resumen":"We found an innovative way of finding individuals from a conspicuous species in complex habitats such as urban areas. The aim of this study was to detect as much Burrowing owls nest as possible in order to develop an ecological and behavioral study. For this we performed an on-line survey through social networks, specifically Facebook. Out of these surveys we detected and locate 36 new nests of this owl´s species. We found out that developing on-line surveys through social networks to ask for bird?s location is an innovative and cost-effective method to obtain information relatively much faster than would take more used methods such as field surveys.","palabras_clave":"Athene cunicularia|bird surveys|social networks|urban areas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39140,"idioma_id":4,"titulo":"Photodegradation routes of the herbicide bromoxynil in solution and sorbed on silica nanoparticles","resumen":"Some organic contaminants dissolved in natural waters tend to adsorb on suspended particles and sediments. In order to mimic the photodegradation routes in natural waters of bromoxynil (BXN)adsorbed on silica, we here prepare and characterize silica nanoparticles modified with BXN (NP-BXN).  We measure the direct photolysis quantum yield of aqueous BXN at 307 nm (0.064  0.001) and detect the formation of bromide ions as a reaction product. Under similar conditions the photolysis quantum yield of BXN bonded to NP-BXN is much lower (0.0021  0.0004) and does not lead to formation of bromide ions. The rate constant of the reaction of NP-BXN with the excited triplet states of riboflavin, a molecule employed as a proxy of chromophore dissolved organic matter (DOM) was measured in laser  flash-photolysis experiments. The rate constants for the overall (kt) and chemical interaction (kr) of singlet oxygen with NP-BXN were also measured. Kinetic computer simulations show that the relevance of the direct and indirect (through reactions with reactive species generated in photoinduced processes)photodegradation routes of BXN is very much affected by sorption on silica. Immobilization of the herbicide on the particles, on one hand, affects the photolysis mechanism and lowers its photolysis quantum yield. On the other hand, the results obtained in aqueous suspensions indicate that immobilization also lowers the rate of collisional encounter, which affects the quenching rate constants of excited triplet states and singlet oxygen with the herbicide.","palabras_clave":"BROMOXYNIL|PHOTODEGRADATION|SILICA PARTICLES|NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39141,"idioma_id":4,"titulo":"'Novel magnetite nanoparticles coated with waste sourced bio-based substances as sustainable and renewable adsorbing materials'","resumen":"This study examines the possibility of using a biobased product isolated from urban solid wastes as a material for  environmental technological applications. To this end, Fe3O4 nanoparticles (NPs) coated with different amounts of soluble  biobased products (SBO) were synthesized as a low-cost nanoadsorbent for the removal of pollutants in wastewater. Particles of  10 nm diameter with an Fe3O4 core and SBO shell were obtained. The concentration of SBO employed in the synthesis had no  effect on the size and structure of the NPs but ruled the pHPZC and aggregation of the nanoparticles in water. The cationic dye  crystal violet (CV) was used as a model pollutant to test the adsorption capacity of the nanoparticles. The results indicated that  both the medium pH and NP dosage were significant parameters to enhance the removal of CV. The results contribute to the  studies that show how wastes can become a source of revenue through the industrial exploitation of their chemical value.","palabras_clave":"MAGNETITE|NANOPARTICLES|WASTE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39142,"idioma_id":4,"titulo":"Resting metabolic rate and heat increment of feeding in juvenile South American fur seals (Arctocephalus australis)","resumen":"Bio-energetic models used to characterize an animal´s energy budget require the accurate estimate of different  variables such as the resting metabolic rate (RMR) and the heat increment of feeding (HIF). In this study, we  estimated the in air RMR of wild juvenile South American fur seals (SAFS; Arctocephalus australis) temporarily  held in captivity by measuring oxygen consumption while at rest in a postabsorptive condition. HIF, which is  an increase in metabolic rate associated with digestion, assimilation and nutrient interconversion,was estimated  as the difference in resting metabolic rate between the postabsorptive condition and the first 3.5 h postprandial.  As data were hierarchically structured, linear mixed effect models were used to compare RMR measures under  both physiological conditions. Results indicated a significant increase (61%) for the postprandial RMR compared  to the postabsorptive condition, estimated at 17.93 ± 1.84 and 11.15 ± 1.91 mL O2 min&#8722;1 kg&#8722;1, respectively.  These values constitute the first estimation ofRMR and HIF in this species, and should be considered in the energy  budgets for juvenile SAFS foraging at-sea.","palabras_clave":"Arctocephalus australis|Energetic|Fur Seals|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39143,"idioma_id":4,"titulo":"Sweet corn ( Zea mays L .) growth and yield are influenced by establishment methods","resumen":"Six experiments were performed in the term of three years in order to explore andcompare the effects of transplanting and direct sowing (DS) on sweet corn (Zea mays L.) growth, earliness and yield. Different genotypes, tray cell sizes (volume) and seedling ages were assayed. In all experiments, direct sowing was performed with a final separation of 0.25 m between plants in each row. Growth parameters (height, leaf area and ear size) were reduced with the increase of age and\/or decrease of the tray cell size, mainly in cultivars with early flowering i.e., low cumulative corn heat unit (CHU) requirements. Earlier harvests were obtained in transplanting compared to direct sowing, although with lower yields. When the thermal time accumulated by plants in the trays was higher than 100 CHU, the yield decreased by 3.91% (R2 = 0.79) for each unit of CHU. The results indicate that the transplanted sweet corn yield was generally lower than of direct seeded plants, and differences grew bigger as the tray cell volume was smaller and the seedlings age increased","palabras_clave":"TRAY CELL VOLUME|SEEDLING TRANSPLANT|TRANSPLANT AGE|YIELD|DIRECT SOWING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39144,"idioma_id":4,"titulo":"TOXOPLASMA GONDII HSP90: POTENTIAL ROLES IN ESSENTIAL CELLULAR PROCESSES OF THE PARASITE","resumen":"HSP90 is a widely distributed and highly conserved molecular chaperone that is ubiquitously expressed throughout nature, being one of the most abundant proteins within non-stressed cells. This chaperone is up-regulated following stressful events and has been involved in many cellular processes. In T. gondii, HSP90 could be linked with many essential processes of the parasite such as host cell invasion, replication and tachyzoite-bradyzoite interconversion. A Protein-Protein Interaction (PPI) network approach of TgHSP90 has allowed inferring how these processes may be altered. In addition, data mining of T. gondii phosphoproteome and acetylome has allowed the generation of the phosphorylation and acetylation map of TgHSP90. This review focuses on the potential roles of TgHSP90 in parasite?s biology and the analysis of experimental data in comparison with its counterparts in yeast and humans.","palabras_clave":"T. GONDII|HSP90|CELL |CYCLE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39145,"idioma_id":4,"titulo":"Comment on 'Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach'","resumen":"The present manuscript is a comment on the article entitled ??Binding of alkaloid harmalol to DNA: Photophysical                    and calorimetric approach?? by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the                    authors reported the chemical structure as well as the absorption spectra of harmalol at different pH.                    On the bases of the previous publications and our own present results, the assignment of the number                    of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species                    are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of                    the interaction with DNA.","palabras_clave":"fotosensitizers|DNA|harmalol|carbolines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39146,"idioma_id":4,"titulo":"HEME-OXYGENASE - 1 IMPLICATIONS IN CELL MORPHOLOGY AND THE ADHESIVE BEHAVIOR OF PROSTATE CANCER CELLS.","resumen":"Prostate cancer (PCa) is the second leading cause of cancer death in men. Although previous studies in PCa have focused on cell adherens junctions (AJs), key players in metastasis, they have left the molecular mechanisms unexplored. Inflammation and the involvement of reactive oxygen species (ROS) are critical in the regulation of cell adhesion and the integrity of the epithelium. Heme oxygenase-1 (HO-1) counteracts oxidative and inflammatory damage. Here, we investigated whether HO-1 is implicated in the adhesive and morphological properties of tumor cells. Genes differentially regulated by HO-1 were enriched for cell motility and adhesion biological processes. HO-1 induction, increased E-cadherin and &#946;-catenin levels. Immunofluorescence analyses showed a striking remodeling of E-cadherin\/&#946;-catenin based AJs under HO-1 modulation. Interestingly, the enhanced levels of E-cadherin and &#946;-catenin coincided with a markedly change in cell morphology. To further our analysis we sought to identify HO-1 binding proteins that might participate in the regulation of cell morphology. A proteomics approach identified Muskelin, as a novel HO-1 partner, strongly implicated in cell morphology regulation. These results define a novel role for HO-1 in modulating the architecture of cell-cell interactions, favoring a less aggressive phenotype and further supporting its anti-tumoral function in PCa.","palabras_clave":"PROSTATE CANCER|HEME-OXYGENASE-1|MUSKELIN|E-CADHERIN|B-CATENIN|ADHERENS JUNCTIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39147,"idioma_id":4,"titulo":"Diet of nestling Spectacled Tyrants (Hymenops perspicillatus) in the southeast Pampas Region, Argentina","resumen":"We studied the diet of nestling Spectacled Tyrants (Hymenops perspicillatus) in the southeast Pampas region, Argentina. From November 2012 to January 2013 we determined the diet by recognizing items prey using video footage when parents feed their chicks. We surveyed 18 nests, achieving 54 hr of recording time. We identified a total of 125 prey items, representing 33 different taxa, grouped into four classes: Insecta, Arachnida, Chilopoda, and Amphibia. Insects accounted for 94% of total number of preys. The most frequent prey were orthopterans (Caelifera), unidentified lepidopteran larvae, and odonats (Zygoptera). Lepidopterans were numerically the most important prey item in November, odonats in December, and orthopterans in January. Diet of nestling was generalist in terms of the consumption of insects, and the changes in the prey consumption along the breeding season support an opportunistic feeding behavior by Spectacled Tyrant.","palabras_clave":"flycatcher|insectivore|digital camera|tyraniidae"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39148,"idioma_id":4,"titulo":"The electrogenic cardiac sodium bicarbonate co-transporter (NBCe1) contributes to the reperfusion injury","resumen":"Background: Although the participation of the electrogenic sodium\/bicarbonate cotransporter (NBCe1) in the recovery from an intracellular acid load is recognized, its role in ischemia?reperfusion is still unclear.Methods and results: Our objective was to assess the role of NBCe1 in reperfusion injury. We use selective functional antibodies against extracellular loop 3 (a-L3) and loop 4 (a-L4) of NBCe1. a-L3 inhibits and a-L4 stimulates NBCe1 activity. Isolated rat hearts were submitted to 40 min of coronary occlusion and 1 h of reperfusion. a-L3, a-L4 or S0859 ? selective Na+-HCO3 - co-transport inhibitor ? were administered during the initial 10 min of reperfusion. The infarct size (IS) was measured by triphenyltetrazolium chloride staining technique. Postischemic systolic and diastolic functions were also assessed. a-L3 and S0859 treatmentsdecreased significantly (Pb.05) the IS (16±3% for a-L3 vs. 32±5% in hearts treated with control nonimmune serum and 19±3% for S0859 vs. 39±2% in untreated hearts). Myocardial function during reperfusion improvedafter a-L3 treatment, but it was not modified by S0859. The infusion of a-L4 did not modify neither the IS nor myocardial function.Conclusions: TheNBCe1 hyperactivity during reperfusion leads to Na+ and Ca2+ loading, conducing to Ca2+ overload and myocardial damage. Consistently, we have shown herein that the selective NBCe1 blockade with a-L3 exerted cardioprotection. This beneficial action strongly suggests that NBCe1 could be a potential target for the treatment of coronary disease.","palabras_clave":"ISCHEMIA|HEART|SODIUM\/BICARBONATE COTRANSPORT|INJURY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39149,"idioma_id":4,"titulo":"Current biotechnological applications of the genus Amycolatopsis","resumen":"Recently there has been increasing interest in possible biotechnological applications of the bacterial genus Amycolatopsis. This genus originally attracted attention for its antibiotic producing capabilities; although it is actually a multifaceted genus and a more diverse range of studies involving biotechnological processes have now been undertaken. Several works have demonstrated that the versatility shown by these bacteria is valuable in industrial applications. Here, we provide a condensed overview of the most important biotechnological applications such as bioremediation, biodegradation and bioconversion, as well as aspects that need to be explored further in order to gain a fuller insight into this genus, including its possible potential in the production of biofuel. Antibiotic production is not discussed since this is well covered by the latest edition of Bergey's Manual of Systematic Bacteriology. To our knowledge this is the first report highlighting the versatility and biotechnological potential of the genus Amycolatopsis","palabras_clave":"APPLICATIONS|ENVIRONMENTAL|AMYCOLATOPSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39150,"idioma_id":4,"titulo":"Classical Antiferromagnetism in Kinetically Frustrated Electronic Models","resumen":"We study, by means of the density matrix renormalization group, the infinite U Hubbard model?with one hole doped away from half filling?in triangular and square lattices with frustrated hoppings, which invalidate Nagaoka?s theorem. We find that these kinetically frustrated models have antiferromagnetic ground states with classical local magnetization in the thermodynamic limit. We identify the mechanism of this kinetic antiferromagnetism with the release of the kinetic energy frustration, as the hole moves in the established antiferromagnetic background. This release can occur in two different ways: by a nontrivial spin Berry phase acquired by the hole, or by the effective vanishing of the hopping amplitude along the frustrating loops.","palabras_clave":"Kinetic antiferromagnetism|Kinetically frustrated models|Calssical antiferromagnetism"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39151,"idioma_id":5,"titulo":"RELACIONES FILOGEOGRÁFICAS DE ALGUNAS COLONIAS DE ALIMENTACIÓN Y ANIDACIÓN DE LA TORTUGA CAREY (ERETMOCHELYS IMBRICATA) EN EL PACÍFICO Y CARIBE COLOMBIANOS","resumen":"La tortuga marina Eretmochelys imbricata habita en aguas tropicales de todos los océanos. La especie está considerada en peligro crítico de extinción por la IUCN y sus poblaciones se encuentran afectadas por el tráfico internacional de los escudos de su caparazón. La presente investigación es pionera en Colombia y en el océano Pacífico oriental tropical, ya que por medio de la amplificación de secuencias de la región control del ADNmt se caracterizaron genéticamente las poblaciones de la especie localizadas en: 1) Parque Nacional Natural Gorgona, 2) Corales del Rosario y San Bernardo y 3) Cabo de la Vela (La Guajira). Se encontraron dos haplotipos nuevos para el Pacífico Oriental, aunque los índices de diversidad fueron bajos (h: 0.2857 ± 0.1964; &#960;: 0.0009 ± 0.0008). Para la población de Corales del Rosario y San Bernardo se encontraron cinco haplotipos e índices de diversidad altos (h: 0.9333 ± 0.1217; &#960;: 0.0089 ±  0.0056). Finalmente, la población del Cabo de la Vela presentó índices de diversidad relativamente altos (h: 0.6429 ± 0.0539; &#960;: 0.0076 ± 0.0041). Los análisis de distancia genética no revelaron diferenciación significativa entre las colonias del Caribe colombiano (&#934;st = 0.002, p > 0.05; Fst = 0.083, p > 0.05); sin embargo, sí se encontró diferenciación entre la colonia anidante del Cabo de la Vela y ocho colonias anidantes en el mar Caribe, lo cual es un patrón característico de la estructura genética a escala global de las tortugas marinas. Por medio de los análisis filogeográficos se observó una profunda división entre el océano Atlántico y la región Pacífico-Índica. Para el filogrupo del Atlántico no se observó una agrupación clara entre los haplotipos, mientras que para el filogrupo del Pacífico-Índico se observó una posible distribución de aislamiento por distancia. El tiempo de divergencia registrado en este estudio entre los linajes del Atlántico y Pacífico-Índico sugiere una separación que pudo haber ocurrido entre el Plioceno y el Pleistoceno (7 Ma), posiblemente influenciada por el levantamiento del istmo de Panamá.","palabras_clave":"Diversidad genética|Filogenia|ADN mitocondrial|Tortugas marinas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39152,"idioma_id":4,"titulo":"Phenotypic evolution of an Atlantic Forest passerine  (Xiphorhynchus fuscus): biogeographic and systematic  implications","resumen":"ver anexo","palabras_clave":"ATLANTIC FOREST|CAATINGA|CERRADO|NICHE SIMULATION|PHENOTYPIC EVOLUTION|PHYLOGEOGRAPHY|WOODCREEPERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39153,"idioma_id":4,"titulo":"GH administration patterns differently regulate epidermal growth factor signaling","resumen":"Current GH administration protocols imply frequent s.c. injections, resulting in suboptimalcompliance. Therefore, there is interest in developing delivery systems for sustained releaseof the hormone. However, GH has different actions depending on its continuous or pulsatileplasma concentration pattern. GH levels and circulating concentration patterns could beinvolved in the regulation of epidermal growth factor receptor (EGFR) expression in liver.Aberrant expression of this receptor and\/or its hyperactivation has been associated with thepathogenesis of different types of carcinoma. Considering that one of the adverse effectsassociated with GH overexpression and chronic use of GH is the increased incidence ofmalignancies, the aim of this study was to analyze the effects of GH plasma concentrationpatterns on EGFR expression and signaling in livers of mice. For this purpose, GH wasadministered by s.c. daily injections to produce an intermittent plasma pattern or by osmoticpumps to provoke a continuously elevated GH concentration. Intermittent injections of GHinduced upregulation of liver EGFR content, augmented the response to EGF, and theinduction of proteins involved in promotion of cell proliferation in female mice. In contrast,continuous GH delivery in male mice was associated with diminished EGFR in liver anddecreased EGF-induced signaling and expression of early genes. The results indicate thatsustained delivery systems that allow continuous GH plasma patterns would be beneficial interms of treatment safety with regard to the actions of GH on EGFR signaling and itspromitogenic activity.","palabras_clave":"GROWTH HORMONE|EPIDERMAL GROWTH FACTOR|INTRACELLULAR SIGNALING|LIVER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39154,"idioma_id":4,"titulo":"Coexistence of halloysite and iron-bearing clays in an altered ignimbrite, Patagonia, Argentina","resumen":"The Mamil Choique halloysite deposits of Patagonia, Argentina, contain randomlydistributed green clay inclusions and patches within the halloysite mass. Halloysite has been formed from the thorough alteration of rhyolitic to dacitic ash fall tuffs and ignimbrites of the Huitrera Formation, Eocene age, under ambient conditions. The smectites present in the clay inclusions havebeen determined as ferruginous beidellites with variables amounts of Fe3+ in octahedral sites. The weathering activity that caused the formation of halloysite was also responsible for the genesis of the iron-bearing clay minerals, the formation of which was controlled mainly by permeability. Textural variations within the rock indicate favourable local geochemical environments for the formation of the green clay minerals present","palabras_clave":"IRON-BEARING SMECTITES|HALLOYSITES|PATAGONIA|ARGNTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39155,"idioma_id":4,"titulo":"Combined effect of ultrasound, mild heat shock and citric acid to retain greenness, nutritional and microbiological quality of minimally processed broccoli (Brassica oleracea L.): An optimization study","resumen":"tResponse surface methodology (RSM) and Box?Behnken design were used to study the combined hurdleeffect of mild heat time (1?5 min) at 50&#9702;C, ultrasonic processing time (0?10 min) and citric acid concen-tration (0?2%) on the quality of refrigerated broccoli after 10 d of storage at 5&#9702;C. Treatment effects wereevaluated on weight loss, superficial colour (hue angle (H&#9702;) and total colour difference (E)), headspacegas composition (O2and CO2), overall browning potential, chlorophyll content, ascorbic acid content,mesophilic counts and overall visual quality (OVQ) and optimize the process by means of the desirabil-ity function. Predicted models were found to be significant with high regression coefficients (91?97%).High regression coefficients indicated that second-order polynomial models could be used to predict andoptimize the quality retention in minimally processed broccoli during storage. The mesophilic counts,ascorbic acid content and the overall visual quality were significantly influenced by the three indepen-dent variables either independently or interactively. Both thermal and ultrasonic treatments were foundto be critical factors influencing changes in chlorophyll content, O2concentration inside the package,hue angle and E. On the other hand, thermal treatment and citric acid concentration were found to besignificant on overall browning potential. By using the desirability function approach and consideringsuperficial colour parameters, O2concentration, mesophilic counts, browning potential, ascorbic acidand chlorophyll content, the optimum processing conditions were 7.5 min of ultrasonic treatment, 3 minof a heat shock treatment and a citric acid concentration of 1.5%. These results were in good agreementwith the maximum found from the canonical analysis performed from the response surface when onlyconsidering sensorial analysis. Under these optimal processing conditions it is possible to employ cit-ric acid treatment in combination with ultrasonic and thermal treatments as hurdles for retention ofgreen colour, nutritional quality, microbial control and for extending shelf life of refrigerated minimallyprocessed broccoli.© 2014 Elsevier B.V. All rights reserved.","palabras_clave":"HURDLE TECHNOLOGY|OPTIMIZATION|DESIRABILITY FUNCTION|POSTHARVEST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39156,"idioma_id":4,"titulo":"Functional and structural alterations of cardiac and skeletal muscle mitochondria  in heart failure patients","resumen":"Background and Aims. The fundamental mechanisms involved in the genesis and progression  of heart failure are not clearly understood. The present study was conducted  to analyze the cardiac mitochondrial involvement in heart failure, the possible parallelism  between cardiac and skeletal muscle and if there is a link between clinical symptoms and  mitochondrial damage.  Methods. Left ventricle and pectoral biopsies were obtained from patients with heart failure  (n: 21) and patients with inter-auricular communication as the unique diagnosis for  surgery (n: 6). Mitochondria were isolated from these tissues and studied through electron  microscopy, spectrophotometry to measure the activity of respiratory complex III and  immunohistochemistry to determine the presence of reactive oxygen species.  Results. More than 90% of cardiac and skeletal muscle mitochondria presented structural  and functional alterations in relation to an increment in the reactive oxygen species production,  even in patients without the presence of any clinical Framingham criteria.  Conclusions. We demonstrated some parallelism between cardiac and skeletal muscle  mitochondrial alterations in patients with heart failure and that these alterations begin  before the major clinical Framingham criteria are installed, pointing to mitochondria  as one of the possibly responsible factors for the evolution of cardiac disease.","palabras_clave":"insuficiencia cardiaca|mitocondrias|especies reactivas del oxigeno"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39157,"idioma_id":4,"titulo":"Circulating Trypanosoma cruzi populations differ from those found in the tissues of the same host during acute experimental infection","resumen":"We evaluated the presence and distribution of two Trypanosoma cruzi natural isolates in  blood, heart, skeletal muscle, liver and spleen tissues in the acute phase of the experimental infection  (35 days post infection) in order to determine if the populations present in blood were different to  those found in the tissues of the same host. Thirty mice were infected with 50 forms of each isolate or  with a combination of them. Presence and molecular characterization of the parasites in the host  tissues were determined by specific PCR. Cardiac and skeletal muscle alterations were analyzed by  histological studies. T. cruzi variability in the host tissues was analyzed through RFLP studies. Both  isolates used consisted of a mixture of two T. cruzi lineages. Specific PCRs were positive for most of the  samples from the 3 groups analyzed. Cardiac and skeletal muscle sections from the groups infected  with one isolate presented mild to moderate inflammatory infiltrates; the group infected with both  isolates showed severe inflammatory infiltrates and the presence of amastigote nests in both tissues.  Different parasite populations were found in circulation and in the tissues from the same host. These  results are important for patients with high probability of mixed infections in endemic areas and  contribute to the knowledge of parasite\/host interactions.","palabras_clave":"Parásitos circulantes|linajes de T.cruzi|corazón|higado, bazo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39158,"idioma_id":5,"titulo":"LA ERUPCIÓN DEL 22 DE DICIEMBRE DE 2012 DEL VOLCÁN COPAHUE, NEUQUÉN, ARGENTINA: CARACTERIZACIÓN DEL CICLO ERUPTIVO Y SUS PRODUCTOS","resumen":"The December 22nd 2012 eruption of the Copahue volcano, Neuquén, Argentina: Characterization of the eruptive cycle and its products This paper describes the characteristics, nature and distribution of the products of the 12\/22\/2012 eruption of the Copahue volcano (Neuquén Province, Argentina). The eruptive cycle was dominated by a pulsatory behavior, with a continuous decrease in the released energy since the onset of the eruption in the morning of December 22, when the eruptive column reached its maximum height (1,500-2,000 m). The volcanic plume extended for almost 250 km toward the ESE of the volcano and was characterized by a mean width of 20 km in proximal areas and 35 km in distal areas. This initial pulse was accompanied by significant SO2 emissions. A second, less intense, eruptive pulse occurred during the afternoon of December 22, leading to the development of a smaller volcanic plume. Eruption products can be classified as: i) ballistic bombs and blocks emitted from the eruptive center, and ii) fallout pyroclasts deposited directly from the volcanic plume, including large flattened juvenile fragments of highly vesiculated scoria. The characteristics of the eruptive event lead to the accumulation of tephra up to a distance of about 40 km from the crater, distributed along a surface of about 200 km2 to the SE of the volcano. Petrographic analysis performed on the fallout deposits showed the presence of juvenile fragments with different degrees of vesiculation and accessory fragments of hydrothermally altered subvolcanic rocks. Ballistic bombs and blocks were dispersed to a distance of 1,800-1,900 m from the eruptive center. We estimate a VEI 2 eruption intensity, with an emitted volume of about 0.005 km3, which rapidly declined in about 48 hours after the onset of the eruption. The initial stages of the eruption were related to the interaction of an ascending column of magma with the shallow hydrothermal system of the volcano, triggering a hydromagmatic eruption. Once the conduit was open, the progressive decompression of the system led to an eruption dominated by a pulsatory magmatic fragmentation.","palabras_clave":"copahue|erupción|hidromagmatismo|depósitos de caída"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39159,"idioma_id":4,"titulo":"Reproductive parameters in the critically endangered Blue-throated Macaw: limits to the recovery of a parrot under intensive management","resumen":"VER ADJUNTO","palabras_clave":"NO CORRESPONDE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39160,"idioma_id":4,"titulo":"Impaired proplatelet formation in immune thrombocytopenia: a novel mechanism contributing to decreased platelet count","resumen":"The pathophysiological mechanisms contributing to the decreased platelet count in immune thrombocytopenia (ITP) are not entirely understood. Here, we investigated the key step of proplatelet formation (PPF) by studying the effect of ITP plasma in thrombopoiesis. Normal cord blood-derived mature megakaryocytes were cultured in the presence of recalcified plasma from ITP patients, and PPF was evaluated by microscopic analysis. Patient samples induced a dose-dependent inhibition in PPF, as well as decreased complexity of proplatelet architecture. Although slightly increased, plasma-induced megakaryocyte apoptosis was not related to PPF impairment. Purified IgG reproduced the inhibitory effect, while platelet-adsorbed plasma induced its reversion, suggesting the involvement of auto-antibodies in the inhibition of thrombopoiesis. Impaired PPF, induced by ITP plasmas bearing anti-GPIIb-IIIa antibodies, was related to their ability to interfere with the normal function of this integrin, as assessed by megakaryocyte PAC-1 binding and &#946;3 integrin phosphorylation while the presence of anti-glycoprotein Ia-IIa auto-antibodies was associated with loss of normal inhibition of PPF induced by type I collagen. In conclusion, abnormal thrombopoiesis comprising decreased PPF and morphological changes in proplatelet structure are induced by patient samples, unveiling new mechanisms contributing to decreased platelet count in ITP.","palabras_clave":"auto-antibodies| immune thrombocytopenia,| thrombopoiesis|proplatelets"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39161,"idioma_id":5,"titulo":"Recampesinización y recreación política del campesinado  en un escenario de despliegue de los agronegocios El caso de las reservas campesinas en el Chaco","resumen":"En el presente trabajo abordaremos las transformaciones ocurridas en las últimas décadas en la estructura productiva y económica de la provincia de Chaco, caracterizada históricamente por el monocultivo de algodón. Dichas transformaciones que se evidencian en el avance de la frontera agrícola, en base al frente oleaginoso producen un reordenamiento territorial que tiene como efecto la constitución de territorialidades diferenciadas y en conflicto, entre los grupos económicos del agronegocio y el campesinado. En este contexto existen organizaciones campesinas, como el caso de la Unión de Pequeños Productores de Chaco (Unpeproch), que a través de las ocupaciones de tierras y la conformación de Reservas Campesinas están recuperando y construyendo nuevas territorialidades. En este trabajo consideraremos a las ocupaciones de tierras y a las Reservas Campesinas como parte de un proyecto político y de estrategias económicas en las que pueden vislumbrarse alternativas políticas al modelo de agronegocios excluyente y predominante en la actualidad. De esta manera intentaremos dar cuenta de cómo aún en los contextos más adversos y en condiciones desiguales el campesinado define estrategias y realiza acciones orientadas a su recreación como sujeto político y económico.","palabras_clave":"Campesinado|reservas campesinas|agronegocios|recreación política"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39162,"idioma_id":5,"titulo":"FUGA DE CEREBROS EN EL SECTOR SALUD: UN FENÓMENO QUE  CONDICIONA EL DESARROLLO EN AMÉRICA LATINA?","resumen":"El presente artículo tiene por objetivo encontrar variables que expliquen la fuga de cerebros en el sector salud para los países de América Latina. En el trabajo se realizan estimaciones econométricas para 20 países de América Latina, con objetivo de encontrar una explicación explicar parsimoniosa de la fuga de cerebros y cómo puede afectar la mortalidad infantil o la esperanza de vida. Las conclusiones a las que se arriban varían según el método econométrico utilizado, panel ó mínimos cuadrados en tres etapas.","palabras_clave":"fuga de cerebros|sector salud|America Latina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39163,"idioma_id":5,"titulo":"Calibración de un modelo hidrológico unidimensional para las estaciones de Diamante y Paraná, Entre Ríos","resumen":"Dado el impacto que tiene el contenido de humedad en el suelo en meteorología y en distintas actividades como la agricultura y la ganadería, es de importancia desarrollar métodos que mejoren la estimación de la misma. Esta tarea puede llevarse a cabo mediante la ubicación de sensores de humedad en el terreno, a través del uso de información satelital o utilizando Modelos Hidrológicos. Este trabajo presenta los resultados de la calibración del modelo hidrológico CLASS U3M 1D para las estaciones de Diamante y Paraná, provincia de Entre Ríos. A partir de las cartas de suelo de Argentina y de las funciones de edafotransferencia, se estimaron algunos de los parámetros hidráulicos del modelo. Los resultados obtenidos fueron estadísticamente significativos al 99%, con valores de correlación entre la serie observada y simulada, en general, del orden de 0.6 y 0.7 para Diamante y entre 0.3 y 1 para Paraná. El Error Cuadrático Medio se mantuvo aproximadamente en 0.06 m3\/m3 para Diamante y entre 0.03 m3\/m3 y 0.18 m3\/m3 para Paraná según la simulación. Al correlacionar las simulaciones de la humedad del suelo obtenidas a partir de modificar el método de estimación de la evapotranspiración, usada como variable de entrada al modelo hidrológico, se obtuvieron valores cercanos a 1. Esto permite utilizar métodos más sencillos en la estimación de la evapotranspiración con resultados igualmente robustos","palabras_clave":"MODELOS HIDROLOGICOS|HUMEDAD DEL SUELO|FUNCIONES DE EDAFOTRANSFERENCIA|EVAPOTRANSPIRACIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39164,"idioma_id":4,"titulo":"Ni-Nb mixed oxides: one-pot synthesis and catalytic activity for oxidative dehydrogenation of ethane","resumen":"Ni-Nb mixed oxides were prepared by two methods, conventional evaporationmethod and combustion synthesis. With the latter technique, the mixed oxide can bequickly prepared from an aqueous solution of metal precursors (oxidizers) and sucrose(fuel). The solids with a 0.15\/0.85 Nb\/Ni atomic ratio were characterized by differenttechniques including X-ray diffraction, scanning electron microscopy, XPS and Ramanspectroscopy, and N2 adsorption-desorption measurements.Ni-Nb mixed oxides were tested in the oxidative dehydrogenation (ODH) ofethane to ethylene. The catalyst prepared by combustion synthesis (a technique that issimpler than evaporation method) showed a good performance in terms of activity andstability levels when compared to the catalyst synthesized by the evaporation method,even for long-term runs. Regarding the effect of the metal precursor, nickel nitrate andammonium niobate oxalate generated the better catalyst in both synthesis routes.Surface activity for ethane consumption and ethylene formation was higher than thatobserved for the sample prepared by the evaporation method with the same metalprecursors.Both prepared catalysts presented almost constant ethylene yields for 120 h instream at 400°C and W\/F =0.06 g s\/cm3 (8 and 15% for combustion and evaporationsynthesis, respectively) with a slight decrease over time on stream (13 and 11%).","palabras_clave":"ETHYLENE|OXIDATIVE DEHYDROGENATION|CATALYST SYNTHESIS|NICKEL|NIOBIUM|MIXED OXIDES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39165,"idioma_id":5,"titulo":"Desequilibrios territoriales en la Provincia de Río Negro : análisis cuantitativo","resumen":"El presente artículo tiene como objetivo demostrar  empíricamente la existencia actual de desequilibrios regionales en la provincia  de Río Negro desde una óptica cuantitativa y en base a datos del Censo Nacional  de Población y Viviendas del año 2010, realizado por el Instituto Nacional de  Estadísticas y Censos ? INDEC -. &nbsp;      En &nbsp;primera  instancia se introduce al lector en la temática relativa a las relaciones entre  población&nbsp; y desarrollo. Posteriormente y  para demostrar la existencia de desequilibrios territoriales en la provincia de  Río Negro, se analiza el patrón de asentamiento de la población y el acceso de  los hogares a servicios básicos y de comunicaciones.       &nbsp;&nbsp;&nbsp;&nbsp; El  propósito de este trabajo es brindar una  herramienta para la identificación de necesidades futuras y contribuir a sentar  las bases para una política poblacional que se&nbsp;  integre a una política de desarrollo provincial. &nbsp;","palabras_clave":"Desequilibrios territoriales|Población|Desarrollo Regional"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39166,"idioma_id":4,"titulo":"Tempol attenuates atherosclerosis associated with metabolic syndrome via decreased vascular inflammation and NADPH-2 oxidase expression","resumen":"Oxidative stress is an important factor in the generation of vascular injury in atherosclerosis. Chronic administration of fructose in rodents is able to facilitate oxidative damage. In the present study we evaluated the role of Tempol, a superoxide dismutase mimetic, on the effect of high fructose intake in apolipoprotein E-deficient (ApoE-KO) mice. Rodents were fed with fructose overload (FF, 10% w\/v) for 8 weeks and treated with Tempol 1 mg\/kg\/day the latest 4 weeks. Tempol revert the pro-oxidant effects caused by FF, diminished lipid peroxidation and impaired vascular NADPH oxidase system through the downregulation of p47phox expression in the vascular wall. Tempol inhibited the expression of vascular adhesion molecule 1 (VCAM-1) in aorta and reduced the development of atheroma plaques. Our results indicate that tempol attenuates oxidative stress by interfering with the correct assembly of Nox2 oxidase complex in the vascular wall and is able to reduce atherosclerosis. Thus tempol represents a potential therapeutic target for preventing risk factors associated with metabolic syndrome.","palabras_clave":"ANTIOXIDANTES|ATEROSCLEROSIS|ESTRES OXIDATIVO|SINDROME METABOLICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39167,"idioma_id":4,"titulo":"Integrating demographic and meteorological data in urban ecology: a case study of container-breeding mosquitoes in temperate Argentina","resumen":"Cities are unique ecosystems emerging and growing worldwide due toongoing urbanizing trends. The urban-rural gradient is an excellent settingto evaluate the effect of urbanization on the distribution of species, amatter of public health concern in the case of disease vectors. Despite this,such distributions are affected by other co-occurring variables, mainlymeteorological, that may be confounded by the urbanization gradient dueto the urban heat island effect and maritime climatological conditions in thecase of coastal cities. To aid in the design of ecological studies within theurban-rural transition zone, a mapping protocol was designed and appliedto Buenos Aires City and its surroundings. Based on road density anddistrict-level population counts, a detailed (1km2-pixel) urbanization mapwas obtained which, combined with a temperature map, rendered a finalurbanization x temperature product with six classes. The resulting zonationwas tested by modeling the distribution of the vector mosquitoes Aedesaegypti and Culex pipiens in artificial containers. The selected modelexplained the occurrence of mosquitoes 59% better than chance as afunction of the urbanization x temperature categories and the naturallighting condition of the container. This novel zonation approach allows forthe partitioning of the environmental heterogeneity prior to the selection ofstudy sites to avoid confounding gradients and presents multipleadvantages, such as making comparisons across cities easier, extrapolatingthe results of site-scale experiments and identifying priority areas forcontrol measures.","palabras_clave":"BUENOS AIRES|URBANIZATION|GENERALIZED LINEAR MIXED MODELS|ENVIRONMENTAL GRADIENTS|MOSQUITO VECTORS|ARTHROPODS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39168,"idioma_id":4,"titulo":"Lifting via cocycle deformation","resumen":"We develop a strategy to compute all liftings of a Nichols algebra over a finite dimensional cosemisimple Hopf algebra. We produce them as cocycle deformations of the bosonization of these two. In parallel, we study the shape of any such lifting.","palabras_clave":"pointed Hopf algebras"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39169,"idioma_id":4,"titulo":"New record of the deep-sea crab Ethusina abyssicola from  the Mar del Plata Canyon, Argentina","resumen":"Ethusina abyssicola Smith, 1884 (Decapoda, Ethusidae) belongs to Ethusidae, a family of small and deep-sea crabs adapted to carrying objects on their backs for camouflage. Ethusina abyssicola is the only species of that genus occurring in the West Atlantic, is distributed from New England, USA to Cape Frio, Brazil, and is one of the best adapted brachyuran crabs to inhabit deep water (up to 5046 m). We reported herein E. abyssicola in the deep and under-explored ?Mar del Plata Canyon? (38°01&#8242;S, 53°39&#8242;W), Argentina. The specimens were taken at 2934 m, which represents the greatest depth record for any brachyuran crab below 25°S in the southwestern Atlantic. Although E. abyssicola from the canyon mostly agree with previous descriptions, their outer orbital spines pointed forward and not outwards as in the original description. The significance of this difference is presently unknown and will require genetic analysis to be clarified.","palabras_clave":"ethusid|porter crab|abyssal bottom|south-western Atlantic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39170,"idioma_id":4,"titulo":"Load-carrying capacity of timber-to-timber joints of fast-growing Argentinean Eucalyptus grandis with nails of small diameter laterally loaded in double shear. Analysis according to the criterion adopted by European standards","resumen":"The present paper reports the results of an investigation regarding the   study of the load-carrying capacity of connections with nails of small   diameter pneumatically driven in timber-to-timber joints of fast-growing   Argentinean Eucalyptus grandis. The   effectiveness of the equations provided by Eurocode 5 for calculating   the lateral load-carrying capacity of these joints was checked for the   specimens exhibiting the geometrical parameters adopted by the European   design rule and also for those with reduced spacing and end distances. A   failure mode presenting features common to both j and k types of   failure according to the criterion of the European design rule confirmed   that the plastic hinges could be developed before brittle failure due   to splitting or block shear occurred, even if the specimens present   reduced spacing and end distances. The load-slip curves confirmed   ductile behaviour for all cases. The empirical results showed that the   structural design is situated on the conservative side if the equations   adopted by Eurocode 5 are applied to the analysed connections when the   spacing and end distances recommended by this design rule are used. The   results also showed that the joint area may be decreased by up to 31&nbsp;%   in relation to that corresponding to the recommended spacing and end   distances without reducing the load-bearing capacity below the   characteristic value determined according to the European design rule.","palabras_clave":"LOAD-CARRYING CAPACITY|CONNECTIONS|NAILS OF SMALL DIAMETER|EUCALYPTUS GRANDIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39171,"idioma_id":5,"titulo":"Prospecciones durante la campaña 2013 revelaron la ausencia de la roya naranja de la caña de azúcar en la Argentina","resumen":"La roya naranja de la caña de azúcar, causada por el hongo Puccinia kuehnii E.J. Butler, afecta el follaje de la planta limitando su desarrollo y provocando pérdidas de rendimiento en cultivares susceptibles. En el año 2000 esta enfermedad afectó a la principal variedad cultivada en Australia, Q124, provocando disminuciones estimadas entre 30 y 40% tanto en el tonelaje como en el rendimiento, que resultó la pérdida económica más importante en la historia de la industria azucarera de ese país. Fue detectada por primera vez en América en julio de 2007, en Florida (EE.UU.), registrándose ese mismo año también en Costa Rica, Nicaragua y Guatemala. A partir del primer reporte fue citada en México, El Salvador, Cuba, Panamá, Brasil, Colombia y Louisiana (EE.UU.). La aparición de la roya naranja en Brasil, en el 2009, motivó el inicio de un trabajo conjunto entre técnicos de la Estación Experimental Agroindustrial Obispo Colombres (EEAOC) y el Instituto Nacional de Tecnología Agropecuaria (INTA), para adoptar medidas ante el posible ingreso de esta nueva enfermedad a la Argentina. En el presente trabajo se describen las principales características de esta enfermedad y se mencionan las condiciones ambientales predisponentes para el desarrollo del patógeno. Asimismo, se resumen las principales actividades encaradas durante la campaña 2013 ante esta potencial problemática para el área cañera Argentina.","palabras_clave":"SACCHARUM SPP.|PUCCINIA KUHENII|DIAGNOSTICO E ENFERMEDADES|DIAGNÓSTICO MOLECULAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39172,"idioma_id":4,"titulo":"The acute inhibitory effects of iodide excess on sodium\/iodide symporter expression and activity involve the PI3K\/Akt signaling pathway","resumen":"Iodide (I-) is an irreplaceable constituent of thyroid hormones and an important regulator of thyroid function, since high concentrations of I- downregulate NIS expression and function. In thyrocytes, activation of PI3K\/Akt cascade also inhibits NIS expression and function. Since I- excess and PI3K\/Akt signaling pathway induce similar inhibitory effects on NIS expression, we aimed to study whether the PI3K\/Akt cascade mediates the acute and rapid inhibitory effect of I- excess on NIS expression\/activity. Here, we reported that the treatment of PCCl3 cells with I- excess increased Akt phosphorylation under normal or TSH\/insulin starving conditions. I- stimulated Akt phosphorylation in a PI3K-dependent manner, since the use of PI3K inhibitors (wortmannin or LY294002) abrogated the induction of I- effect. Moreover, I- inhibitory effect on NIS expression and function were abolished when the cells were previously treated with specific inhibitors of PI3K or Akt (Akti1\/2). Importantly, we also found that the effect of I- on NIS expression involved the generation of reactive oxygen species (ROS). Using the fluorogenic probes dihydroethidium (DHE) and MitoSOX Red, we observed that I- excess increased ROS production in thyrocytes, and determined that mitochondria were the source of anion superoxide. Furthermore, the ROS scavengers N-acetyl cysteine (NAC) and Ebselen blocked the effect of I- on Akt phosphorylation. Overall, our data demonstrated the involvement of the PI3K\/Akt signaling pathway as a novel mediator of the I--induced thyroid autoregulation, linking the role of thyroid oxidative state to the Wolff-Chaikoff effect.","palabras_clave":"SODIUM-IODIDE SYMPORTER (NIS)|PI3K\/AKT CASCADE |REACTIVE OXYGEN SPECIES (ROS)|THYROID AUTOREGULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39173,"idioma_id":4,"titulo":"PBDEs, PCBs and Organochlorine Pesticides distribution in edible fish from Negro River basin, Argentinean Patagonia","resumen":"DDTs, endosulfans, HCHs, chlordanes, PCBs and PBDEs levels were determined in different tissues of pat-  agonian silverside (Odontesthes hatcheri) from the Upper (UV), Middle (MV) and Lower (LV) valleys of the  Negro River, Argentina. Results showed a direct relation between pollutant levels in &#64257;sh and land uses  along the basin. All tissues showed decreasing levels from headwaters (UV) to downstream (LV). A sig-  ni&#64257;cant predominance of organochlorine pesticides (306?3449 ng g 1  lipid) followed by RPCBs (65?  3102 ng g 1  lipid) and RPBDEs (22?870 ng g 1  lipid) was observed in all tissues and valleys, suggesting  agriculture as the main source of pollutants in this basin. Pesticides were dominated by DDTs (90% pp 0 -  DDE) followed by endosulfan (a- &gt; b- &gt; sulfate), c-HCH and c-chlordane showing the prevalence of legacy  compounds. Endosulfan levels point out the current use of technical endosulfan in the surrounding areas.  The highest PCBs and PBDEs concentrations observed in &#64257;sh from UV were associated to hydroelectric  power plants and industries established upstream. PCB &#64257;ngerprint presented a prevailing contribution  of hexa-CBs (66 ± 7%) and penta-CBs (27 ± 9%), with a similar composition to Aroclor 1254?1260. The  predominance of BDE-47 (69 ± 17%) among PBDEs, followed by BDE-100 and BDE-99, suggests possible  debromination processes. These results were similar to worldwide trends found in &#64257;shes and environ-  mental compartments. PCBs levels in silverside muscles along the Negro River exceeded the maximum  limits for safe consumption, suggesting a possible human health risk related to silverside ingest. There-  fore, a continued long-term monitoring of organic co","palabras_clave":"pollution|PBDE|OCP|cuenca rio Negro"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39174,"idioma_id":4,"titulo":"Ionic liquids as solvents for liquid scintillation technology. Cerenkov counting with 1-Butyl-3-Methylimidazolium Chloride","resumen":"We report the detection of &#268;erenkov luminescence after the incorporation of a few droplets of a physiological solution of 2-deoxi-2(18F)fluorine-D-glucose into the ionic liquid 1-Butyl-3-Methylimidazolium Chloride (BmimCl). The phenomenon is attributed to the &#946;+ particles having energy above the threshold energy value for &#268;erenkov radiation in this medium. The presence of another type of radiation that could eventually cause coincidences in the photodetectors was safely discarded. We show that this property serves to determine the activity of a 18F solution by means of the novel TDCR-&#268;erenkov technique. The results were compared with those obtained from the classic TDCR scintillation method using a commercial scintillation cocktail. The activity values obtained from both methods were found to be virtually identical within the experimental uncertainties. The fact that high energy &#946; particles in BmimCl generates &#268;erenkov photons makes this ionic liquid a promising compound for future research in detection and quantification of ionizing radiation, and it provides a potential alternative for applications in nuclear technology. ","palabras_clave":"Ionic liquid|Cerenkov light|1-Butyl-3-Methylimidazolium Chloride|TDCR Cerenkov method"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39175,"idioma_id":4,"titulo":"BIPM comparison BIPM.RI(II)-K1.Eu-152 of activity measurements of the radionuclide 152Eu for the VNIIM (Russia), the LNE?LNHB (France) and the CNEA (Argentina), with linked results for the COOMET.RI(II)-K2.Eu-152 comparison","resumen":"Three new participants in the BIPM.RI(II)-K1.Eu-152 comparison have been added to the previous results and this has produced a revised value for the key comparison reference value (KCRV), calculated using the power-moderated weighted mean. A link has been made to the COOMET.RI(II)-K2.Eu-152 comparison held in 2010 through the VNIIM who participated in both comparisons. Three National Metrology Institutes (NMIs) used the K1 or K2 comparisons to update their degree of equivalence. The degrees of equivalence between each equivalent activity measured in the International Reference System (SIR) and the KCRV have been calculated and the results are given in the form of a table for four NMIs in the BIPM.RI(II)-K1.Eu-152 comparison, three participants in the COOMET.RI(II)-K2.Eu-152 comparison and the 18 other participants in the previous CCRI(II)-K2.Eu-152 comparison. A graphical presentation is also given.","palabras_clave":"INTERCOMPARISON|NUCLIDE STANDARDIZATION|METROLOGY|ACTVITY MEASUREMENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39176,"idioma_id":4,"titulo":"Evaluation of Arbuscular Mycorrhizal Fungi Capacity to Alleviate Abiotic Stress of Olive (Olea europaea L.) Plants at Different Transplant Conditions","resumen":"The capacity of roots to sense soil physicochemical parameters plays an essential role in maintaining plant nutritional and developmental functions under abiotic stress. These conditions generate reactive oxygen species (ROS) in plant tissues causing oxidation of proteins and lipids among others. Some plants have developed adaptive mechanisms to counteract such adverse conditions such as symbiotic association with arbuscular mycorrhizal fungi (AMF). AMF enhance plant growth and improve transplant survival by protecting host plants against environmental stresses. The aim of this study was to evaluate the alleviation of transplanting stress by two strains of Rhizophagus irregularis (GC2 and GA5) in olive. Our results show that olive plants have an additional energetic expense in growth due to an adaptative response to the growing stage and to the mycorrhizal colonization at the first transplant. However, at the second transplant the coinoculation improves olive plant growth and protects against oxidative stress followed by the GA5-inoculation. In conclusion, a combination of two AMF strains at the beginning of olive propagation produces vigorous plants successfully protected in field cultivation even with an additional cost at the beginning of growth.","palabras_clave":"ARBUSCULAR MYCORRHIZA|STRESS|OLIVE|ENZIMES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39177,"idioma_id":4,"titulo":"Growth dynamics of geographically different arbuscular mycorrhizal fungal isolates belonging to the 'Rhizophagus clade' under monoxenic conditions","resumen":"The growth dynamics of extraradical mycelium and spore formation of fourteen ´Rhizophagus´ isolates from different sites in Argentina were evaluated under monoxenic conditions. A modified Gompertz model was used to characterize the development of mycelium and spores for each isolate under the same conditions. The lag time, maximal growth rate, and total quantity of both extraradical hyphae and spores were determined. Wide variability among isolates was detected and all growth parameters were significantly altered by fungal isolate. Discriminant analysis differentiated isolates primarily based on the extent of extraradical hyphae produced, yet such differences did not conclusively correspond to phylogenetic relationships among closely related isolates based on partial SSU sequences. Given that the ´Rhizophagus´ isolates were grown under controlled conditions for many generations, the expression of phenotypic variability could be attributed to genetic differences that are not completely resolved by phylogenetic analysis employing the small ribosomal gene.","palabras_clave":"GLOMEROMYCOTA|GROWTH DYNAMICS|IN VITRO|RHIZOPHAGUS INTRARADICES|RHIZOPHAGUS IRREGULARIS|VARIABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39178,"idioma_id":4,"titulo":"Essential Oils Nanoformulations for Stored-Product Pest Control - Characterization and Biological Properties","resumen":"The lethal and sublethal activity of poly(ethylene glycol) (PEG) nanoparticles containing essential oils(EO), also the physicochemical characterization, were determined against Tribolium castaneum andRhizopertha dominica. The 10% ratio EO-PEG nanoparticles showed an average diameter 75%; after 6 month of storage their size did not change significantly and the amount of the EOs decreased 25%, approximately. Furthermore, during this period, no chemical derivates were observed. The EOs nanoparticles produced a notable increase of the residual contact toxicity apparently due to the slow and persistent release of the active terpenes. In addition, the nanoformulation enhanced the EO contact toxicity and altered the nutritional physiology of both stored product pest. The results indicated that these novel systems could be used in integrated pest management program for T. castaneum and R. dominica control.","palabras_clave":"nanoparticles|geranium and bergamot essential oils|release profiles|residual contact toxicity|nutritional physiology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39179,"idioma_id":4,"titulo":"Composition, repellent and insecticidal activities of two south american plants against the stored grain pests Tribolium castaneum and Tribolium confusum (Coleoptera: Tenebrionidae)","resumen":"As part of a screening programto evaluate the biological activity of indigenous plants, we report the composition and the bioactivityof essential oils (EOs) extracted from T´e de Burro Aloysia polystachya [(Griseb.)Moldenke] and Lemon Verbena Aloysia citriodora[Palau] against two of the most widespread secondary pests of stored products, the red flour beetle Tribolium castaneum [Herbst]and the confused flour beetle Tribolium confusum [Jacqueline du Val]. Analysis by gas chromatography-mass spectrometry of theEOs led the identification of their major constituents and their relative proportions. EOof A. citriodora showed the highest repellentactivity against both beetles (&gt;70%). On the other hand, both plants showed fumigant toxicity only against T. confusum, withoutsignificant differences between them (LC50 values of 5.92 and 5.53mg\/L air for A. polystachya and A. citriodora, resp.). For contacttoxicity (topical applications) the EO of A. polystachya wasmore effective (LD50 = 7.35 &#120583;g\/insect) than the EO of A. citriodora (LD50= 13.8&#120583;g\/insect) only against T. castaneum. On the other hand, T. confusum was not susceptible by contact to any of these EOs.These results provide important tools for the development of an Integrated Pest Management (IPM) program.","palabras_clave":"COMPOSITION|BIOACTIVITY|STORED GRAIN PEST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39180,"idioma_id":4,"titulo":"Design  and  development  of  aqueous  nanoformulations  for  mosquito control","resumen":"Microemulsions (ME) are thermodynamically stable isotropic mixtures of oil, water and surfactant; they would also be attractive as potential insecticidal products due to the high bioviability of the active ingredient, attributable to the small sizes of the oil drops. A laboratory study was conducted in order to compare the biological effect of oil in water (o\/w) geranium EO and geraniol MEs and emulsions, against Culex pipiens pipiens mosquito larvae. The systems were based on three non-ionic surfactants (Cremophor EL, Brij 35, Tween 80). The MEs showed dispersed phase diameters in the range of 8 to 14 nm and had low PDI values (< 0.2). The MEs were analyzed by TEM,indicating that they had nearly spherical morphology.  The microemulsified systems based on geranium EO and those of geraniol produced a notable increase of the larvicidal activity when compared with the respectably emulsions, concluding that the biological effect is related with the diameter of the dispersed phase. The smallest drops achieved the highest larvicidal activity, being the aqueous nanoformulations based on geraniol most effective than those of geranium  EO. However, geranium microemulsions are preferred due to their residual  toxicological profiles.  The results indicate that these novel systems could be used in integrated pest management program for the Culex pipiens pipiens.","palabras_clave":"MICROEMULSIONS|GERANIOL, GERANIUM ESSENTIAL OIL|CULEX PIPIENS PIPIENS |LARVICIDAL EFFECT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39181,"idioma_id":4,"titulo":"Effects of the Synthetic Estrogen 17a-Ethinylestradiol on Aromatase Expression, Reproductive Behavior and Sperm Quality in the Fish Jenynsia multidentata","resumen":"The synthetic estrogen 17alfa-ethynylestradiol  (EE2) has been increasingly detected in sewage effluents in  the last two decades. The aim of the present study was  determined if EE2 exposure adversely affected reproduction  in internally fertilizing fish species Jenynsia multidentata.  Sexual behavior, brain and gonadal aromatase  expression as well as sperm quality were evaluated. The  brain aromatase expression, reproductive behavior, spermatozoa  viability and gonadosomatic index were sensitive  biomarkers of EE2 effects on this species. The condition  factor, hepatosomatic index, gonadal aromatase expression,  sperm count and sperm velocities were unaltered after EE2  exposure. The present work highlights the importance of  using a combination of several biomarkers to study the  effects of estrogenic compounds, especially when trying to  link these results to potential population-level effects.","palabras_clave":"ENDOCRINE DISRUPTION|XENOESTROGEN COMPOUNDS|ONE-SIDED LIVEBEARING FISH|SEXUAL ACTIVITY|AROMATASA EXPRESSION|SPERM PARAMETERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39182,"idioma_id":4,"titulo":"Spermatozoa characterization in the one-sided livebearing Jenynsia multidentata  (Cyprinodontiformes: Anablepidae)","resumen":"Several  sperm  parameters  have  been  used  as  useful  tools  to  evaluate  fish  fertility.   Within  teleosts,  approximately  3%  of  fish  species  are  known  to  be  viviparous.  The  Order   Cyprinodontiformes includes several species with internal fertilization. Within this order most of   the  studies  about  sperm  quality  have  been  focused  mainly  on  the  Poeciliidae  family.  The   livebearing  fish  Jenynsia  multidentata  (Anablepidae)  inhabits  an  extensive  area  of  the   Neotropical region and it has been used as a useful fish laboratory model to evaluate the effects   of xenobiotics through different biomarkers. The present work characterized the sperm of this   species  through  a  simple  protocol  of  semen  collection.  Sperm  population  showed  linearity   greater than 89% and 70% of fish have a straight line and curvilinear velocity valued between 50   and 100µm\/s. Although 85% of individuals showed a proportion of live sperm higher than 60%,   the  male  population  had  a  high  degree  of  heterogeneity  in  its  sperm  count.  Morphometry   analyses  showed  a  total  sperm  and  head  lengths  of  46.66  ±  2.06µm  and  3.46  ±  0.41µm,   respectively. A rather long midpiece region (9.12 ± 0.65µm) was registered, which may indicate   high energy-producing capabilities of the spermatozoa. This study established basic parameter   values  which  could  be  useful  for  evaluating  reproductive  potential  of  J.  multidentata   populations.","palabras_clave":"JENYNSIA MULTIDENTATA|SPERMATOZOA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39183,"idioma_id":4,"titulo":"Next-generation phenotyping in plants: old problems, new promises","resumen":"Amazing progress in DNA sequencing technology has enabled to gather a large amount of genomic information. Nowadays, genomic interest has moved towards phenotype in the expectation that phenotyping improvements could increase our knowledge about genotype, phenotype and environment relationships. In this post-genomic era, phenomics emerge as a new discipline that aims the acquisition of high-throughput phenotypic information at all levels of biological organization integrating  different -omic data. New technology in plant phenotyping spans a wide range of complexity including image analyzing softwares, large-scale platforms and field-phenotyping systems. The progressively increasing number of phenotyping tools and the advantages and opportunities for plant sciences are discussed.","palabras_clave":"PLANT PHENOTYPING|GENOTYPE, PHENOTYPE AND ENVIRONMENT RELATIONSHIPS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39184,"idioma_id":4,"titulo":"Spermatozoa characterization in the one-sided livearing Jenynsia multidentata (Cyprinodontiformes: Anablepidae)","resumen":"Several  sperm  parameters  have  been  used  as  useful  tools  to  evaluate  fish  fertility. Within  teleosts,  approximately  3%  of  fish  species  are  known  to  be  viviparous.  The  Order Cyprinodontiformes includes several species with internal fertilization. Within this order most of the  studies  about  sperm  quality  have  been  focused  mainly  on  the  Poeciliidae  family.  The livebearing  fish  Jenynsia  multidentata  (Anablepidae)  inhabits  an  extensive  area  of  the Neotropical region and it has been used as a useful fish laboratory model to evaluate the effects of xenobiotics through different biomarkers. The present work characterized the sperm of this species  through  a  simple  protocol  of  semen  collection.  Sperm  population  showed  linearity greater than 89% and 70% of fish have a straight line and curvilinear velocity valued between 50 and 100µm\/s. Although 85% of individuals showed a proportion of live sperm higher than 60%, the  male  population  had  a  high  degree  of  heterogeneity  in  its  sperm  count.  Morphometry analyses  showed  a  total  sperm  and  head  lengths  of  46.66  ±  2.06µm  and  3.46  ±  0.41µm, respectively. A rather long midpiece region (9.12 ± 0.65µm) was registered, which may indicate high energy-producing capabilities of the spermatozoa. This study established basic parameter values  which  could  be  useful  for  evaluating  reproductive  potential  of  J.  multidentata populations.","palabras_clave":"sperm parameters|morphometry|sperm motility |sperm viability|viviparous fish|Jenynsia multidentata"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39185,"idioma_id":4,"titulo":"Quantum decoherence: a logical perspective","resumen":"The so-called classical limit of quantum mechanics is generally studied in terms of the decoherence of the state operator that characterizes a system. This is not the only possible approach to decoherence. In previous works we have presented the possibility of studying the classical limit in terms of the decoherence of relevant observables of the system. On the basis of this approach, in this paper we introduce the classical limit from a logical perspective, by studying the way in which the logical structure of quantum properties corresponding to relevant observables acquires Boolean characteristics.","palabras_clave":"QUANTUM LOGIC|DECOHERENCE|LATTICE|BOOLEAN LOGIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39186,"idioma_id":4,"titulo":"Expression of urokinase type plasminogen activator receptor (uPAR) in the bovine oviduct: Relationship with uPA effect on oviductal epithelial cells","resumen":"Urokinase type plasminogen activator (uPA) is an oviductal fluid component whose activity is regulated by binding to urokinase type plasminogen activator receptor (uPAR). In this study uPAR and uPA gene expression in bovine oviduct were evaluated and similar expression patterns for both uPAR and uPA mRNAs were observed during the estrous cycle. Immunolocalization of uPAR at the apical zone of epithelial cells suggests that uPA action would be focalized in the oviductal lumen, triggering intracellular signaling pathways. As uPAR expression was also observed in in vitro cultures of oviductal epithelial cells, the effect of uPA was explored using this culture model. Real-time RT-PCR demonstrated that c-fos expression in oviductal cell cultures increases under uPA stimulation. These results suggest that uPA\/uPAR binding would be involved in signaling pathways that activate transcription factors and would regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment. © 2014 Elsevier Ltd.","palabras_clave":"Bovine|Oviduct|uPA|uPAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39187,"idioma_id":4,"titulo":"Metal dynamics and tolerance of Typha domingensis exposed to high concentrations of Cr, Ni and Zn","resumen":"T. domingensis was exposed to a 100 mg L-1 Cr + 100 mg L-1 Ni + 100 mg L-1 Zn solution. Metal tolerance and metal accumulation in plant tissues and sediment were studied over time. Although removal rates were different, the three metals were efficiently removed from water. Leaf and root tissues showed high metal concentration. However, the sediment showed the highest accumulation. During the first hours of contact, metals were not only accumulated by sediment and roots but they were also taken up by the leaves in direct contact with the solution. Over time, metals were translocated from roots to leaves and vice versa. Metals caused growth inhibition and a decrease in chlorophyll concentration, and affected anatomical parameters. Despite these sub-lethal effects, T. domingensis demonstrated that it could accumulate Cr, Ni and Zn efficiently and survive an  accidental dump of high concentrations of contaminants in systems such as natural and constructed wetlands.","palabras_clave":"CONTAMINANTS|EMERGENT MACROPHYTES|PHYTOTOXICITY|WETLANDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39188,"idioma_id":5,"titulo":"De la imagen de ciencia declarativa a la de la práctica en el aula: Las imágenes del profesorado entre la visión democrática y la deficitaria","resumen":"      Dentro de los estudios que se ocupan de indagar las  imágenes de ciencia que sustenta el profesorado, nuestro trabajo se enfoca en  la posible coexistencia, en algunos profesores, de al menos dos imágenes de  ciencia contrapuestas: una de carácter declarativo, democrática, vinculada con  posicionamientos epistemológicos de corte contextualista, y otra, la que  subyace a la práctica de aula de esos profesores (a la que damos en llamar la ?imagen  enactiva?) que se vislumbra como deficitaria y asistencialista, más relacionada  con posturas epistemológicas empiro-positivistas,. Consideramos que este tipo  de imagen deficitaria se constituye en un verdadero obstáculo para la educación  científica, especialmente aquella destinada a jóvenes de contextos socialmente  desfavorecidos. Las instancias de formación inicial y continua del profesorado  en naturaleza de la ciencia (NdC) a través de intervenciones con enfoque CTS  contribuirían a superar la mirada de déficit, y por ende, a promover la  consecución de las finalidades de la educación científica para todos y todas.      &nbsp;        ","palabras_clave":"Imágenes de ciencia|Formación del profesorado|Jovénes en riesgo social"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39189,"idioma_id":4,"titulo":"Envy-free division of discrete cakes","resumen":"We address the problem of existence of an envy-free distribution of pieces among two or more players in the cake-cutting setting with the minimum number of cuts. Our cakes are discrete in the sense that the players? valuations are concentrated on atoms. These atoms are placed on an interval and no two players give positive values to atoms placed at the same position. We prove the existence of an envy-free allocation for any discrete cake and any number of players by resorting to Sperner?s Lemma, a suitable triangulation, and moving-knife arguments. Our results also apply to pies, which are defined over circumferences instead of intervals.","palabras_clave":"Fair division|Cake cutting|Sperner's lemma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39190,"idioma_id":4,"titulo":"New Method for Sintering Silica Frits for Capillary Microcolumns","resumen":"One of the main steps in the manufacture of robust and efficient packed  capillary microcolumns for electro- and capillary chromatography is the  generation of porous devices to retain the packed beds. Frits based on sintered silica particles have been found to give the best results in terms of mechanical resistance and efficiency. The conventional procedure to produce these kinds of frits consists in a radial heating of the packed material with either a flame or an electrical resistance, but the frits thus obtained have many drawbacks as a result of the procedure rather than the silica per se as the base material. In the present work we investigated a new approach to produce silica-based retaining devices involving the frontal exposure of a short silica-particle bed packed at the end of a capillary tube. The capillary isradially insulated and frontally exposed to the heat of a muffle oven,  generating a transfer of heat that is not radial but rather throughout the capillary axis. This procedure resulted in substantial advantages: an improved radial homogeneity, a protection of the external polyimide, and a generation of extremely short (400?600 &#956;m) frits that were highly anpermeable and avoided bubble formation.","palabras_clave":"CAPILLARY MICROCOLUMNS|ELECTROCHROMATOGRAPHY|SINTERED SILICA FRITS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39191,"idioma_id":4,"titulo":"Estimating soil moisture and the relationship with crop yield using surface temperature and vegetation index","resumen":"Soil moisture availability affects rainfed crop yield. Therefore, the development of methods for preharvest yield prediction is essential for the food security. A study was carried out to estimate regional  crop yield using the Temperature Vegetation Dryness Index (TVDI). Triangular scatters from land surface temperature (LST) and enhanced vegetation index (EVI) space from MODIS (Moderate Resolution Imaging  Spectroradiometer) were utilized to obtain TVDI and to estimate soil moisture availability. Then soybean and wheat crops yield was estimated on four agro-climatic zones of Argentine Pampas. TVDI showed a  strong correlation with soil moisture measurements, with R2 values ranged from 0.61 to 0.83 and also it was in agreement with spatial pattern of soil moisture. Moreover, results showed that TVDI data can be used effectively to predict crop yield on the Argentine Pampas. Depending on the agro-climatic zone,R2 values ranged from 0.68 to 0.79 for soybean crop and 0.76 to 0.81 for wheat. The RMSE values were 366 and 380 kg ha&#8722;1 for soybean and they varied between 300 and 550 kg ha&#8722;1 in the case of wheat crop. When expressed as percentages of actual yield, the RMSE values ranged from 12% to 13% for soybean and 14% to 22% for wheat. The bias values indicated that the obtained models underestimated soybean and  wheat yield. Accurate crop grain yield forecast using the developed regression models was achieved one to three months before harvest. In many cases the results were better than others obtained using only  a vegetation index, showing the aptitude of surface temperature and vegetation index combination to reflect the crop water condition. Finally, the analysis of a wide range of soil moisture availability allowed us to develop a generalized model of crop yield and dryness index relationship which could be applicable in other regions and crops at regional scale.","palabras_clave":"SOIL MOISTURE|OPTICAL THERMAL|CROP YIELD|REMOTE SENSING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39192,"idioma_id":4,"titulo":"Subsurface soil moisture estimation by VI-LST method","resumen":"In this letter, the relationship between temperature vegetation dryness index (TVDI) from the Moderate Resolution Imaging Spectroradiometer and subsurface soil moisture (SM) cover crop and native grassland of the Argentine Pampas is analyzed.High correlation (R2 > 0.69) between TVDI and SM measurements was found at different soil depths. In addition, we  found that the potential of this index to reflect subsurface soil  wetness fluctuations depends on root system depth, root distribution  in the soil, and physical soil characteristics. Results indicate  that thermal and reflectance data combination could be used to  monitor subsurface SM below vegetated areas.","palabras_clave":"optical|thermal |soil moisture|stress index"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39193,"idioma_id":4,"titulo":"A combined experimental and computational study of the esterification reaction of glycerol with acetic acid","resumen":"This work describes theoretical and experimental studies on glycerol esterification to obtain acetins focusing in the obtaining isomers. The reaction of glycerol with acetic acid was carried out on Amberlyst 36 wet. Density functional theory calculations on level of M06-2X functional  and 6-311+G(d,p) basis set are carried out and the most stable structures of the reactants and products are located by considering a large amount of conformers. The thermodynamics is discussed in terms of the calculated reaction Gibbs free energy. The AIM theory was used to characterize reactants and products. The glycerol esterification with acetic acid is found to be thermodynamically favored, with exothermal property. These agree well with experiments and allow us to explain the relative selectivity of products.","palabras_clave":"Density functional theory|AIM analysis|glycerol esterification|catalysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39194,"idioma_id":4,"titulo":"Aquatic ferns from the Upper Cretaceous Loncoche Formation, Mendoza, central-western, Argentina","resumen":"Herein, we report new fossil remains with marsileaceous affinity associated with dispersed microspores corresponding to Crybelosporites, different types of massulae of Salvianiaceae (Paleoazolla patagonica and Azolla circinata), and a single megaspore assigned to the fossil genus Grapnelispora. These fossils were recovered from the Late Cretaceous Loncoche Formation, at the Calmu-Co section, Malargüe Group, Northern Neuquén Basin, Mendoza, Argentina. The macrofossils include scattered leaflets, rhizomes, roots and a sporocarp-like structure. They share characters with members of the aquatic fern family Marsileaceae; however, based on the characters preserved, they could not be placed within any extant or fossil species; therefore the fossils are better included within a new fossil-taxon, Mendozaphyllum loncochense. Dispersed spores of Crybelosporites pannuceus, also belonging to Marsileaceae, were recovered from the entire section. Additionally, abundant isolated massulae with affinity to the aquatic fern family Salviniaceae, and a single megaspore assigned to Grapnelispora loncochensis, were identified from the plant bearing layer. The presence of Marsileaceae fossils in the Campanian-Maastrichtian Loncoche Formation, Mendoza, extend towards the north the paleogeographical distribution of the family Marsileaceae in Argentina, since previous records are from Patagonia. A fluvial to deltaic environment with lacustrine episodes was suggested by the sedimentology of the lower and middle part of the Calmu-Co section and supported by the abundant fresh water algae recovered from the palynological association. This was probably the optimum habitat for the growth of aquatic ferns related to Marsileaceae and Salviniaceae, and explains its abundance in the studied sediments. ","palabras_clave":"Heterosporous ferns|Fossil remains|Upper Cretaceous|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39195,"idioma_id":4,"titulo":"Experimental and theoretical results on electron emission in collisions  between He targets and dressed Li(q+) (q = 1, 2) projectiles","resumen":"We investigate experimentally and theoretically the electron emission in collisions between He atoms and Li q + (q = 1, 2) projectiles at intermediate to high incident energies. We report on measured absolute values of double-differential cross-sections, as a function of the emitted electron energy and angle, at a collision energy of 440 keV u &#8722;1 . The different contributions from target ionization, projectile ionization, and simultaneous target?projectile ionization arecalculated with the quantum-mechanical continuum distorted wave and continuum distorted wave?eikonal initial state models, and with classical trajectory Monte Carlo simulations. There is an overall good agreement of the calculations with the experimental data for electron emission cross-sections.","palabras_clave":"EXPERIMENTAL|THEORETICAL|ELECTRON-EMISSION|HELIUM-TARGETS|DRESSED-PROJECTILES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39196,"idioma_id":4,"titulo":"Fluctuating temperatures terminate dormancy in Cynara cardunculus seeds by turning off ABA synthesis and reducing ABA signalling, but not stimulating GA synthesis or signalling","resumen":"Fluctuating temperatures terminate seed dormancy in many species, including Cynara cardunculus (L.) var. sylvestris. Termination of physiological dormancy requires low ratios of abscisic acid (ABA)\/gibberellins (GA). In a previous paper we have shown that physiological responses to fluctuating temperatures comprise a reduction of abscisic acid (ABA) content and sensitivity. However, a possible stimulation of GA synthesis was also suggested as part of the mechanism. That possible stimulation, as well as the identification of potential regulatory sites for ABA and GA metabolism and signalling involved in the termination of dormancy by fluctuating temperatures, are yet to be determined. In this study, we measured GA content and sensitivity in seeds incubated under constant and fluctuating temperatures. We also assessed the expression of several genes involved in ABA and GA metabolism and signalling. Our results show that fluctuating temperatures reduce ABA\/GA ratios through a reduction in ABA accumulation during incubation but without altering GA synthesis as compared to that observed under constant temperatures. On the other hand, fluctuating temperatures did not increase sensitivity to GA. Fluctuating temperatures reduced the expression of CycaNCED and CycaABI5 (ABA synthesis and signalling genes) with a temporal pattern that coincides with the interruption of ABA accumulation that precedes germination of seeds incubated under fluctuating temperatures. However, fluctuating temperatures did not modify the expression of CycaCYP707A2 (ABA inactivation) as compared to that observed under constant temperatures. Consistent with our determinations of GA content and sensitivity, fluctuating temperatures did not modify the expression of GA synthesis (CycaGA3ox) and signalling genes (CycaRGL2 and CycaGAI) in relation to that observed at constant temperatures. These results show that fluctuating temperatures terminate dormancy in Cynara cardunculus seeds through an interruption in ABA accumulation and a reduction in ABA signalling exerted at the level of CycaNCED and CycaABI5 expression.","palabras_clave":"ABSCISIC ACID|DORMANCY|FLUCTUATING TEMPERATURES|GENE EXPRESSION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39197,"idioma_id":5,"titulo":"Efectos del herbicida Ron-do® sobre Cerodaphnia reticulata (Crustacea, Cladocera) y degradabilidad del glifosato (N-fosfometilglicina) en condiciones experimentales","resumen":"En Argentina la expansión de áreas sembradas con soja transgénica produjo un incremento en el consumo de plaguicidas, principalmente del herbicida glifosato (N-fosfometilglicina), con el consiguiente impacto sobre las aguas superficiales y su biota, el que ha sido documentado por numerosos estudios. La necesidad de conocer el efecto del herbicida más utilizado en la Argentina sobre una especie de cladócero nativo, llevó a plantear los objetivos de este trabajo: 1) evaluar posibles efectos tóxicos del glifosato en su formulación comercial Ron-do®, sobre la sobrevivencia, la fecundidad y la tasa neta de crecimiento poblacional (Ro) de Ceriodaphnia reticulata (Crustacea, Cladocera), en ensayos crónicos durante 13 días; 2) evaluar la degradabilidad del glifosato bajo las mismas condiciones experimentales de los ensayos crónicos, y detectar la posible presencia de su principal metabolito de degradación, el ácido aminometilfosfónico (AMPA). No se observaron efectos adversos sobre la sobrevivencia de C. reticulata pero el incremento en la concentración del contaminante produjo disminución significativa de la fecundidad. Los valores de Ro disminuyeron con el aumento en la concentración de glifosato, mostrando que este parámetro integrador es un buen bioindicador de toxicidad del herbicida estudiado. La vida media del glifosato en el medio sintético estático fue variable según a las concentraciones empleadas; la degradación del glifosato fue gradual a lo largo de los ensayos, sin la aparición de su metabolito AMPA.","palabras_clave":"Glifosato|Ceriodaphnia reticulata|Bioindicadores"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39198,"idioma_id":4,"titulo":"Impact of Eskoba®, a glyphosate formulation, on the freshwater plankton community","resumen":"We analyzed the acute effects of a glyphosate-based herbicide (ESKOBA®) on the microalgae Chlorella vulgaris, the cladoceran Simocephalus vetulus, and the copepod Notodiaptomus conifer and evaluated the recovery ability of the surviving microcrustaceans. Survival, age of first reproduction and fecundity were used as endpoints for S. vetulus and survival and time to reach the adult stage, for N. conifer.  The registered order of sensitivity was: S. vetulus (48h-h-EC50: 21 mg L-1) &gt; C. vulgaris (72 h-EC50: 58.59 mg L-1) &gt; N. conifer (48h-h-EC50: 95 mg L-1). Despite growth of C. vulgaris was stimulated after 24 h of exposure, it was inhibited after 48 h by all tested concentrations. In post-exposure experiments, microcrustaceans reduced their life expectancy, S. vetulus decreased its fertility and N. conifer inhibited its sexual maturity. It was demonstrated that these species can hardly be recovered in the medium-short term.","palabras_clave":"Chlorella vulgaris|Simocephalus vetulus;|Notodiaptomus conifer|Glyphosate"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39199,"idioma_id":5,"titulo":"EFECTO DE ADULTOS EN EL ESTABLECIMIENTO DE JUVENILES DE Calomys musculinus (RODENTIA: SIGMODONTINAE)","resumen":"Bajo la hipótesis de que en poblaciones de clausura los individuos reproductivamente activos de  Calomys musculinus excluyen juveniles de su mismo sexo, se probaron las siguientes predicciones: 1) el grado  de solapamiento entre áreas de acción (AA) de adultos y juveniles del mismo sexo será menor que aquel  registrado entre adultos y juveniles del sexo opuesto; 2) los juveniles se establecerán fuera del AA de adultos  de su mismo sexo. Nuestros resultados apoyaron parcialmente la hipótesis, el efecto sexo-específico de adultos  reproductivamente activos quedó de manifiesto en el establecimiento de machos juveniles respecto al AA de  adultos de su mismo sexo.","palabras_clave":"COMPETENCIA|DISPERSION|ESTABLECIMIENTO|ROEDORES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39200,"idioma_id":4,"titulo":"Microbial Characterization of Microbial Ecosystems Associated to Evaporites Domes of Gypsum in Salar de Llamara in Atacama Desert","resumen":"The Central Andes in northern Chile contains a large number of closed basins whose central depression is occupied by saline lakes and salt crusts (salars). One of these basins is Salar de Llamara (850 m a.s.l.), where large domed structures of seemingly evaporitic origin forming domes can be found. In this work, we performed a detailed microbial characterization of these domes. Mineralogical studies revealed gypsum (CaSO4) as a major component. Microbial communities associated to these structures were analysed by 454 16S rDNA amplicon sequencing and compared between winter and summer seasons. Bacteroidetes Proteobacteria and Planctomycetes remained as the main phylogenetic groups, an increased diversity was found in winter. Comparison of the upper air-exposed part and the lower water-submerged part of the domes in both seasons showed little variation in the upper zone, showing a predominance of Chromatiales (Gammaproteobacteria), Rhodospirillales (Alphaproteobacteria), and Sphingobacteriales (Bacteroidetes). However, the submerged part showed marked differences between seasons, being dominated by Proteobacteria (Alpha and Gamma) and Verrucomicrobia in summer, but with more diverse phyla found in winter. Even though not abundant by sequence, Cyanobacteria were visually identified by scanning electron microscopy (SEM), which also revealed the presence of diatoms. Photosynthetic pigments were detected by high-performance liquid chromatography, being more diverse on the upper photosynthetic layer. Finally, the system was compared with other endoevaporite, mats microbialite and Stromatolites microbial ecosystems, showing higher similitude with evaporitic ecosystems from Atacama and Guerrero Negro. This environment is of special interest for extremophile studies because microbial life develops associated to minerals in the driest desert all over the world. Nevertheless, it is endangered by mining activity associated to copper and lithium extraction; thus, its environmental protection preservation is strongly encouraged.","palabras_clave":"EVAPORITES|MICROBIALITES|ATACAMA DESERT|CHILE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39201,"idioma_id":4,"titulo":"Mechanisms underlying platelet function defect in a pedigree with FPD\/AML: potential role for candidate RUNX1-targets","resumen":"Background   FPD\/AML is an inherited platelet disorder caused by germline RUNX1 mutation and characterized by thrombocytopenia, platelet function defect and leukemia predisposition. The mechanisms underlying FPD\/AML platelet dysfunction remain incompletely clarified. We aimed to determine the contribution of platelet structural abnormalities and defective activation pathways to the platelet phenotype. In addition, by using a candidate gene approach, we sought to identify potential RUNX1-regulated genes involved in these defects.   Methods   Lumi-aggregometry, alpha- and dense- granule content and release, platelet ultrastructure and alphaIIbbeta3 integrin activation and outside-in signaling were assessed in members of one FPD\/AML pedigree. Expression levels of candidate genes were measured and luciferase reporter assay and chromatin immunoprecipitation were performed to study NF-E2 regulation by RUNX1.   Results  Severe decrease in platelet aggregation, together with defective alphaIIbbeta3 integrin activation and combined alpha-delta storage pool deficiency was found. However, while dense granules were markedly reduced, alpha-granule content was heterogeneous. A trend towards decreased platelet spreading was found, while beta3 integrin phosphorylation was impaired, reflecting altered outside-in signaling. A decrease in transcription factor p45 NF-E2 was shown in platelet RNA and lysates, and other deregulated genes included RAB27B and MYL9. RUNX1 was shown to bind NF-E2 promoter in primary megakaryocytes and wild-type RUNX1, but not FPD\/AML mutants, was able to activate NF-E2 expression.   Conclusions  FPD\/AML platelet function defect represents a complex trait and RUNX1 orchestrates platelet function by regulating diverse aspects of this process. This study highlights RUNX-1-target NF-E2 as part of the molecular network by which RUNX1 regulates platelet biogenesis and function.","palabras_clave":"RUNX1|NF-E2|PLATELET DYSFUNCTION|THROMBOCYTOPENIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39202,"idioma_id":4,"titulo":"Polycyclic aromatic hydrocarbons (PAHs) in yerba mate (Ilex paraguariensis) from the Argentinean market","resumen":"Polycyclic aromatic hydrocarbons (PAHs) occurrence in fifty samplesmarketed in the main supermarkets from Argentina was described for thefirst time. A high performance liquid chromatography (HPLC) method wasapplied with fluorescence detector (FLD) and UV-VIS diodes array detector(DAD) for the analysis of sixteen PAHs in ?yerba mate? (Ilexparaguariensis), with percentages recoveries higher than 89% anddetection and quantification limits lower than other methodologies found in revious studies.Contamination expressed as the sum of sixteen analysed PAHs rangedbetween 224.6 and 4449.5 &#956;g kg&#8722;1 on dry mass.The contamination expressed as PAH4 (sum of benzo(a)pyrene, chrysene,benzo(a)anthracene and benzo(b)fluoranthene) varied between 8.3 and512.4 &#956;g kg&#8722;1. The correlation coefficient for PAH2 (sum ofbenzo(a)pyrene and chrysene) and PAH4 groups was of 0.99, for PAH2 andPAH8 (sum of benzo(a)pyrene, chrysene, benzo(a)anthracene,benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(g,h,i)perylene,dibenzo(a,h)anthracene and indeno(1,2,3cd) pyrene) 0.97 and for PAH4and PAH8 0.98.","palabras_clave":"ILEX PARAGUARIENSIS|PAH|BENZOPYRENE|ORGANIC CONTAMINATS|POLYCYCLIC AROMATIC HYDROCARBONS|YERBA MATE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39203,"idioma_id":4,"titulo":"Methotrexate embryopathy after exposure to low weekly doses in early pregnancy","resumen":"Objective: Methotrexate (MTX) is a potent teratogen when used in high doses for cáncer or termination  of tubal pregnancy. In contrast, it has been perceived as safe when used once weekly at low dose for rheumatological conditions.  Methods: A prospective observational controlled study of women exposed to low dose MTX. The control group were women exposed to MTX only before conception.  Results: Among the 8 MTX-exposed pregnancies, there was a case of typical MTX embryopathy, the &#64257;rst to be described to date at this lower once weekly dose Schedule.  Conclusions: This case has important implications for rheumatologists treating women of reproductive age, as the assumption of fetal safety of MTX, implied from small cohorts, is premature.","palabras_clave":"Methotrexate|Pregnancy|Aminopterin embryopathy|Rheumatoid arthritis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39204,"idioma_id":4,"titulo":"A Multi-species Bait for Chagas Disease Vectors","resumen":"Background: Triatomine bugs are the insect vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. These insects are known to aggregate inside shelters during daylight hours and it has been demonstrated that within shelters, the aggregation is induced by volatiles emitted from bug feces. These signals promote inter-species aggregation among most species studied, but the chemical composition is unknown.  Methodology\/Principal Findings: In the present work, feces from larvae of the three species were obtained and volatile compounds were identified by solid phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS). We identified five compounds, all present in feces of all of the three species: Triatoma infestans, Panstrongylus megistus and Triatoma brasiliensis. These substances were tested for attractivity and ability to recruit insects into shelters. Behaviorally active doses of the five substances were obtained for all three triatomine species. The bugs were significantly attracted to shelters baited with blends of 160 ng or 1.6 mg of each substance.  Conclusions\/Significance: Common compounds were found in the feces of vectors of Chagas disease that actively recruited insects into shelters, which suggests that this blend of compounds could be used for the development of baits for early detection of reinfestation with triatomine bugs.","palabras_clave":"Triatominae|Vector control|Traps|chemical ecology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39205,"idioma_id":4,"titulo":"PROGNOSTIC IMPLICATION OF HSPA (HSP70) IN BREAST CANCER PATIENTS TREATED WITH NEOADJUVANT ANTHRACYCLINE BASED CHEMOTHERAPY","resumen":"Neoadjuvant chemotherapy is used in patients with locally advanced breast cancer to reduce the tumor size before surgery. Unfortunately, resistance to chemotherapy may arise from a variety of mechanisms. The heat shock proteins (HSPs), which are highly expressed in mammary tumor cells, have been implicated in anticancer drug resistance. In spite of the widely described value of HSPs as molecular markers in cancer, their implications in breast tumors treated with anthracycline-based neoadjuvant chemotherapy has been poorly explored. In this study, we have evaluated by immunohistochemistry the expression of HSP27 (HSPB1) and HSP70 (HSPA) in serial biopsies from locally advanced breast cancer patients (n= 60) treated with doxorubicin (DOX) or epirubicin (EPI) based monochemotherapy. The serial biopsies were taken at days 1, 3, 7, 21, and compared with the pre-chemotherapy and the surgical biopsies. After surgery the patients received additional chemotherapy with Cyclophosphamide, Methotrexate and 5-Fluorouracil (CMF). High nuclear HSPB1 and HSPA expressions were found in invasive cells after DOX\/EPI administration (P31% of the cells) and cytoplasmic HSPA expressions (>11% of the tumor cells) were associated with better DFS (P=0.0348 and P=0.0118, respectively). We conclude that HSPA expression may be a useful prognostic marker in breast cancer patients treated with neoadjuvant DOX\/EPI chemotherapy, indicating the need to change the administered drugs after surgery for overcoming drug resistance.","palabras_clave":"HSP70|BREAST CANCER|CHEMOTHERAPY|ANTHRACYCLINES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39206,"idioma_id":4,"titulo":"DTU I isolates of Trypanosoma cruzi induce upregulation of Galectin-3 in murine myocarditis and fibrosis","resumen":"Chagas heart disease is a major public concern since 30% of infected patients develop cardiac alterations. The relationship between Trypanosoma cruzi (Tc) discrete typing units (DTUs) and the biological properties exhibited by the parasite population has yet to be elucidated. In this study, we analysed the expression of a-smooth muscle actin (a-SMA) and galectin-3 (Gal-3) associated with cardiac extracellular matrix remodelling a murine chronic cardiomyopathy induced by Tc I genotypes. We found the induction of myocarditis was associated with the upregulation of Col I, a-SMA, Gal-3, IFN-g, and IL-13, as analysed by q-PCR. In myocardial areas of fibrosis, the intensity of myocarditis and significant ECM remodelling correlated with the presence of Col I-, Gal-3-, and a-SMA-positive cells. These results are promising for the further efforts to evaluate the relevance of Gal-3 in Chagas heart disease (ChHD), since this galectine was proposed as a prognosis marker in heart failure (HF) patients.","palabras_clave":"CHAGAS DISEASE|GALECTIN-3|FIBROSIS|SMOOTH MUSCLE ACTIN|DTU"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39207,"idioma_id":4,"titulo":"Short-term effect of UVR on vertical distribution of Cyrtograpsus altimanus and Alexandrium tamarense from Atlantic Patagonia","resumen":"Many marine species spend part of their development in upper layers of the water column, where they may be exposed to solar ultraviolet radiation (UVR). For many of these species, light is one of the key environmental clues which trigger behaviorally-mediated adjustments in vertical distribution. We incubated planktonic larvae of the crab Cyrtograpsus altimanus in column-like aquaria to study their responses with\/without UVR (under a solar simulator) and with\/without a potential prey (the dinoflagellate Alexandrium tamarense). Their vertical distribution was recorded and used to evaluate the combined effects of UVR and the presence of the dinoflagellate on larval behavior. When UVR was absent, most larvae showed a tendency to swim upwards and to aggregate near the surface, regardless of the dinoflagellate presence. However, UVR inhibited this tendency and induced a repellent effect, which resulted in a more homogeneous vertical distribution of larvae. A. tamarense did not affect the vertical distribution of larvae. These results suggest that UVR-triggered, quick adjustments in vertical distribution might be an important strategy for C. altimanus larvae to cope with high solar radiation, which typically occur during the hatching season.","palabras_clave":"CYRTOGRAPSUS ALTIMANUS|DECAPODA|CRAB LARVAE|ULTRAVIOLET RADIATION (UVR)|VERTICAL DISTRIBUTION|ATLANTIC PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39208,"idioma_id":4,"titulo":"Two new species of Neotyphloceras (Siphonaptera: Ctenophthalmidae) from Argentinean Patagonia","resumen":"Two new species of Neotyphloceras Rothschild, parasites of sigmodontine rodents from Argentinean Patagonia, are described and illustrated: N. crackensis n.sp. and N. pardinasi n.sp. These species are compared with their morphologically closest relatives. Males are characterized by the shape of the upper lobe of the fixed process of clasper; the shape and chaetotaxy of the distal arm of sternum IX and by the shape of the crochet of the aedeagus; females by the contour of the distal margin of sternum VII. Neotyphloceras pardinasi n.sp. is reported from western Chubut Province, while N. crackensis n.sp. is known from the eastern regions of Chubut and Santa Cruz Provinces. With these reports, the geographical distribution of Neotyphloceras is extended to eastern Patagonia. A key to the species and subspecies of Neotyphloceras is provided.","palabras_clave":"FLEAS|NEOTYPHLOCERAS|NEOTYPHLOCERATINI|ARGENTINA|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39209,"idioma_id":4,"titulo":"CDC2 Mediates Progestin Initiated Endometrial Stromal Cell Proliferation: A PR Signaling to Gene Expression Independently of Its Binding to Chromatin","resumen":"Although non-genomic steroid receptor pathways have been studied over the past decade, little is known about the direct gene expression changes that take place as a consequence of their activation. Progesterone controls proliferation of rat endometrial stromal cells during the peri-implantation phase of pregnancy. We showed that picomolar concentration of progestin R5020 mimics this control in UIII endometrial stromal cells via ERK1-2 and AKT activation mediated by interaction of Progesterone Receptor (PR) with Estrogen Receptor beta (ERb) and without transcriptional activity of endogenous PR and ER. Here we identify early downstream targets of cytoplasmic PR signaling and their possible role in endometrial stromal cell proliferation. Microarray analysis of global gene expression changes in UIII cells treated for 45 min with progestin identified 97 up- and 341 down-regulated genes. The most over-represented molecular functions were transcription factors and regulatory factors associated with cell proliferation and cell cycle, a large fraction of which were repressors down-regulated by hormone. Further analysis verified that progestins regulate Ccnd1, JunD, Usf1, Gfi1, Cyr61, and Cdkn1b through PR-mediated activation of ligand-free ER, ERK1-2 or AKT, in the absence of genomic PR binding. ChIP experiments show that progestin promoted the interaction of USF1 with the proximal promoter of the Cdc2 gene. Usf1 knockdown abolished Cdc2 progestin-dependent transcriptional regulation and cell proliferation, which also blocked Cdc2 knockdown. We conclude that progestin-induced proliferation of endometrial stromal cells is mediated by ERK1-2 and AKT dependent early regulation of USF1, which directly induces Cdc2. To our knowledge, this is the first description of early target genes of progestin-activated classical PR via crosstalk with protein kinases and independently of hormone receptor binding to the genomic targets.","palabras_clave":"ENDOMETRIUM|PROGESTERONE|ERK|TRANSCRIPTION FACTORS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39210,"idioma_id":4,"titulo":"Plant homeodomain-leucine zipper I transcription factors exhibit different functional AHA motifs that selectively interact with TBP or\/and TFIIB","resumen":"    Homeodomain-leucine  zipper proteins are transcription factors unique to plants, classified in four  subfamilies. Subfamily I members have been mainly associated to abiotic stress  responses. Several ones have been characterized using knock-out or overexpressors  plants, indicating that they take part in different signal transduction  pathways even when their expression patterns are similar and they bind the same  DNA sequence. A bioinformatic analysis has revealed the existence of conserved  motifs outside the HD-Zip domain, including transactivation AHA motifs. Here we  demonstrate that these putative activation motifs are functional. Four members of  the Arabidopsis family were chosen: AtHB1, AtHB7, AtHB12 and AtHB13. All of  them exhibited activation activity in yeast and in plants but with different degrees.  The protein segment necessary for such activation was different for these four  transcription factors as well as the role of the tryptophans they present. When  interaction with components of the basal transcription machinery was tested, AtHB1  was able to interact with TBP, AtHB12 interacted with TFIIB, AtHB7 interacted  with both, TBP and TFIIB while AtHB13 showed weak interactions with any of them,  in yeast two-hybrid as well as in pull down assays. Transient transformation of  Arabidopsis seedlings confirmed the activation capacity and specificity of  these transcription factors and showed some differences with the results  obtained in yeast. In conclusion, the differential activation functionality of  these transcription factors adds an important level of functional divergence of  these proteins, and together with their expression patterns, these differences  could explain, at least in part, their functional divergence.  ","palabras_clave":"HD-Zip|factores de transcripción|motivos AHA|interacción proteína-proteína"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39211,"idioma_id":4,"titulo":"Arabidopsis AtHB7 and AtHB12 evolved divergently to fine tune processes associated with growth and responses to water stress","resumen":"        Background        &nbsp;        Arabidopsis  AtHB7 and AtHB12 transcription factors (TFs) belong to the homeodomain-leucine  zipper subfamily I (HD-Zip I) and present 62 % amino acid identity. These TFs  have been associated with the control of plant development and abiotic stress  responses; however, at present it is not completely understood how AtHB7 and  AtHB12 regulate these processes.         &nbsp;        Results        &nbsp;        By using different expression analysis approaches,  we found that AtHB12 is expressed at  higher levels during early Arabidopsis  thaliana development whereas AtHB7  during later developmental stages. Moreover, by analysing gene expression in single and double Arabidopsis  mutants and in transgenic plants ectopically expressing these TFs, we  discovered a complex mechanism dependent on the plant developmental stage and  in which AtHB7 and AtHB12 affect the expression of each  other. Phenotypic analysis of transgenic plants revealed that AtHB12 induces  root elongation and leaf development in young plants under standard growth  conditions, and seed production in water-stressed plants. In contrast, AtHB7 promotes leaf development,  chlorophyll levels and photosynthesis and reduces stomatal conductance in  mature plants. Moreover AtHB7 delays senescence  processes in standard growth conditions.         &nbsp;        Conclusions        &nbsp;        We  demonstrate that AtHB7 and AtHB12 have overlapping yet specific roles in  several processes related to development and water stress responses. The analysis  of mutant and transgenic plants indicated that the expression of AtHB7 and AtHB12 is regulated in a coordinated manner, depending on the plant  developmental stage and the environmental conditions. The results suggested  that AtHB7 and AtHB12 evolved divergently to fine tune processes associated with  development and responses to mild water stress.   ","palabras_clave":"HD-Zip|AtHB7|AtHB12|Plant gene expression"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39212,"idioma_id":4,"titulo":"A new species of Silvinichthys (Siluriformes, Trichomycteridae) lacking pelvic fins from mid-elevation localities of the southern Andes, with comments on the genus","resumen":"Silvinichthys huachi new species, is described from a stream along the lower slope of the Andean Cordillera in the Provincia de San Juan, Argentina. It shares the distinctive modifications characteristicof Silvinichthys, but is distinguished from the four previously described congeners by the combination of a lack of the pelvic fin and the pelvic girdle, details of pigmentation and various meristic and morphometric features. Silvinichthys huachi is apparently endemic to the type localitysituated within an arid region of western central Argentina in the Andino Cuyana Province. Major gaps in the range of species of Silvinichthys may indicate that the origin of the genus predates the uplift events that subdivided drainages along the eastern slopes of the Andean Cordillera in west central Argentina. Silvinichthys huachi is hypothesized to be the sister species of Silvinichthys bortayro.","palabras_clave":"ANDES|ARGENTINA|CATFISH|TRICHOMYCTERINAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39213,"idioma_id":4,"titulo":"Nucellar beak structure and pollen tube growth in Cucurbitaceae","resumen":"The nucellar beak is a proboscis-like outgrowth of the nucellus at the micropylar end, being the obliged path for the pollen tube entering the ovule. Among the few angiosperm families with nucellar beak, Cucurbitaceae is remarkable because the pollen tube may develop at least two types of growth within the nucelar beak: tubular, and ampulliform. Wondering about the possibility that Cucurbitaceae ovules may express some histological variation that could be related to pollen tube growth within the nucellar beak, we performed a compared anatomical, histochemical study of the nucellar beak and pollen tube growth of ten species of Cucurbitaceae. Results show that Cucurbitaceae ovules are diverse in size and proportions (of integuments, nucellar body, and nucellar beak), and they have at least four types of nucellar beak histology: pectic-tracked, secretory-like, amylaceous, and mixed. Amylaceous and mixed nucellar beaks are related to the ampulliform growth of the pollen tube, which could have appeared independently in most derived tribes of Cucurbitaceae, although information about nucellar beak structure in the basal tribes is still needed. In addition, the understanding of the relation between amylaceous nucellar beaks and the ampulliform growth of the pollen tube, whose function is still to be discovered, might open the possibility of a unique model of pollen tube - ovule co-evolution in angiosperms.","palabras_clave":"OVULE|POLLEN TUBE|NUCELLUS|NUCELLAR BEAK|FERTILIZATION|COEVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39214,"idioma_id":5,"titulo":"De aquí y de allá: análisis integral de un contexto funerario.  Vínculos e interacciones sociales entre Puna meridional y Tierras Bajas orientales","resumen":"El objetivo de este trabajo es presentar un conjunto de evidencias vinculadas con un contexto funerario (1280 ± 60 años AP) procedente del sitio Punta de la Peña 13, Antofagasta de la Sierra, Puna meridional argentina. Con este fin llevamos a cabo un abordaje multidisciplinario que incluyó diversas líneas de análisis: composicionales de cuentas minerales, arqueobotánicos y tecnomorfológicos de artefactos cerámicos y textiles. Los resultados obtenidos permitieron plantear el origen no local para el conjunto mortuorio como rasgo complejo, que a su vez relacionamos con las Tierras Bajas orientales, proponiendo la existencia de interacciones con las poblaciones de la Puna. Estos estudios fueron complementados con información arqueológica y antropológica acerca del conjunto de prácticas vinculadas con las particularidades del contexto. En este sentido, si bien ya habían sido registrados elementos no locales en contextos funerarios del área, inferimos que contenedor y contenido funerario fueron trasladados como una totalidad desde una región alejada, hecho que representa una propuesta inédita y con implicancias relevantes para la puna meridional.","palabras_clave":"PUNA MERIDIONAL |TIERRAS BAJAS ORIENTALES|INTERACCIONES SOCIALES|ARQUEOLOGIA|FUNEBRIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39215,"idioma_id":4,"titulo":"Zinc glycerolate as a novel heterogeneous catalyst for the synthesis of fatty acid methyl esters","resumen":"In this work, zinc glycerolate (ZnGly) is studied as a new catalyst for an environmentally friendly production of biodiesel. The solid was prepared by a simple procedure, characterized and studied in the transesterification of soybean oil with metanol.          ZnGly was able to convert soybean oil into fatty acid methyl esters with 66-76% yield and up to 95-97% triglyceride (TG) conversion in the 100-140 °C reaction temperature range studied. The catalyst showed a long life and could be reused for five catalytic cycles without deactivation or selectivity loss.&nbsp;          The catalyst exhibited good tolerance towards 0.5 wt.% water, without important changes in the TG conversion, but with a 23% decrease in FAME yield.&nbsp;&nbsp;&nbsp;            In the presence of 10 wt.% fatty acids, ZnGly showed an almost complete TG conversion with an increase in FAME yield of 51% (93% FAME selectivity at 50 min reaction time). At 140 °C and in acid oil, ZnGly can be easily transformed into Zn carboxylate and partially re-generated in the presence of glycerol.&nbsp;&nbsp; ","palabras_clave":"Zinc Glycerolate|Biodiesel, |Soybean oil,| Heterogeneous Catalyst"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39216,"idioma_id":4,"titulo":"GPU Accelerated Implementation of Density Functional Theory for Hybrid QM\/MM Simulations","resumen":"The hybrid simulation tools (QM\/MM) evolved into a fundamental methodology for studying chemical reactivity in complex environments. This paper presents an implementation of electronic structure calculations based on density functional theory. This development is optimized for performing hybrid molecular dynamics simulations by making use of graphic processors (GPU) for the most computationally demanding parts (exchange-correlation terms). The proposed implementation is able to take advantage of modern GPUs achieving acceleration in relevant portions between 20 to 30 times faster than the CPU version. The presented code was extensively tested, both in terms of numerical quality and performance over systems of different size and composition.","palabras_clave":"dft|gpgpu|qm\/mm|simulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39217,"idioma_id":4,"titulo":"Electron dynamics in complex environments with real-time time dependent density functional theory in a QM-MM framework","resumen":"This article presents a time dependent density functional theory (TDDFT) implementation to prop- agate the Kohn-Sham equations in real time, including the effects of a molecular environment through a Quantum-Mechanics Molecular-Mechanics (QM-MM) hamiltonian. The code delivers an all-electron description employing Gaussian basis functions, and incorporates the Amber force-field in the QM-MM treatment. The most expensive parts of the computation, comprising the commutators between the hamiltonian and the density matrix?required to propagate the electron dynamics?, and the evaluation of the exchange-correlation energy, were migrated to the CUDA platform to run on graphics processing units, which remarkably accelerates the performance of the code. The method was validated by reproducing linear-response TDDFT results for the absorption spectra of several molecular species. Two different schemes were tested to propagate the quantum dynamics: (i) a leap-frog Verlet algorithm, and (ii) the Magnus expansion to first-order. These two approaches were confronted, to find that the Magnus scheme is more efficient by a factor of six in small molecules. Interestingly, the presence of iron was found to seriously limitate the length of the integration time step, due to the high frequencies associated with the core-electrons. This highlights the importance of pseudopotentials to alleviate the cost of the propagation of the inner states when heavy nuclei are present. Finally, the methodology was applied to investigate the shifts induced by the chemical environment on the most intense UV absorption bands of two model systems of general relevance: the formamide molecule in water solution, and the carboxy-heme group in Flavohemoglobin. In both cases, shifts of several nanometers are observed, consistently with the available experimental data.","palabras_clave":"electron dynamics|tddft|qmmm"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39218,"idioma_id":4,"titulo":"Liquid Chromatography with diode array detection and multivariate curve resolution for the selective and sensitive quantification of estrogens in natural waters","resumen":"      Following the green analytical chemistry principles, an  efficient strategy involving second-order data provided by liquid chromatography (LC) with  diode array detection (DAD) was applied for the simultaneous  determination of estriol, 17&#946;-estradiol, 17&#945;-ethinylestradiol  and estrone in natural water samples. After a simple pre-concentration step, LC-DAD matrix data were  rapidly obtained (in less than 5 min) with a chromatographic system operating  isocratically. Applying a second-order calibration algorithm based on multivariate  curve resolution with alternating least-squares (MCR-ALS), successful  resolution was achieved in the presence of sample constituents that strongly coelute with the  analytes. The flexibility of this multivariate model allowed the  quantification of the four estrogens in tap, mineral, underground and river water samples.  Limits of detection in the range between 3 and 13 ng L&#8722;1,  and relative prediction errors from 2 to 11% were achieved.  ","palabras_clave":"CROMATOGRAFÍA|QUIMIOMETRÍA|ESTROGENOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39219,"idioma_id":4,"titulo":"Inflammation in response to phytohemagglutinin injection in the tuco-tuco Ctenomys talarum: implications for the estimation of immunocompetence in natural populations of wild rodents","resumen":"The immunological variation in wild populations and its relation to life-history traits has recently become acentral topic in the field of evolutionary biology, considering the critical contribution of immunity to an individual?sfitness. A common technique used by ecologists to estimate immunocompetence in wild populations is the phytohemagglutinin(PHA) ? skin test. In this test, the degree of local swelling triggered by PHA is usually considered an estimate ofT-lymphocyte activity, although there is an ongoing debate regarding this interpretation. Here, we coupled the PHA?skintest with a histological analysis to examine the temporal development of the cell-mediated response in the subterraneanrodent Talas tuco-tuco (Ctenomys talarum Thomas, 1898). The inflammation response involved lymphocytes, neutrophils,eosinophils, and macrophages at the site of injection, achieving an increase of total leukocytes from 12 to 48 h afterinjection. However, the abundance of any of the leukocytes observed did not correlate with the degree of swelling at anytime studied, suggesting that caution should be taken when interpreting the results of the PHA-induced swelling response.Particularly, the magnitude of macroscopic swelling should not be considered a priori as indicative of T-lymphocyte activityin wild-caught rodents. Our results highlight the importance of avoiding oversimplified approaches to measuring immunocompetence.","palabras_clave":"CELLULAR IMMUNE RESPONSE|CTENOMYS TALARUM|HISTOLOGY|SUBTERRANEAN RODENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39220,"idioma_id":4,"titulo":"Recognizing vertex intersection graphs of paths on bounded degree trees","resumen":"An $(h,s,t)$-representation of a graph $G$ consists of acollection of subtrees of a tree $T$, where each subtreecorresponds to a vertex of $G$ such that (i) the maximum degree of$T$ is at most $h$, (ii) every subtree has maximum degree at most$s$, (iii) there is an edge between two vertices in the graph $G$if and only if the corresponding subtrees have at least $t$vertices in common in $T$. The class of graphs that have an$(h,s,t)$-representation is denoted $[h,s,t]$.An undirected graph $G$ is called a $VPT$ graph if it is thevertex intersection graph of a family of paths in a tree. Thus,$[h,2,1]$ graphs are the $VPT$ graphs that can be represented in atree with maximum degree at most $h$. In this paper wecharacterize $[h,2,1]$ graphs using chromatic number. We show thatthe problem of deciding whether a given $VPT$ graph belongs to$[h,2,1]$ is NP-complete, while the problem of deciding whetherthe graph belongs to $[h,2,1]-[h-1,2,1]$ is NP-hard. Both problemsremain hard even when restricted to $VPTcap Split$. Additionally,we present a non-trivial subclass of $VPTcap Split$ in whichthese problems are polynomial time solvable.","palabras_clave":"INTERSECTION GRAPHS |VPT GRAPHS|REPRESENTATIONS ON TREES|RECOGNITION PROBLEMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39221,"idioma_id":4,"titulo":"EPT graphs on bounded degree trees","resumen":"An undirected graph G is called an EPT graph if it is the edge  intersection graph of a family of paths in a tree. In this paper, we  answer negatively the question posed by Golumbic et al. [4]: Can  any EPT graph without induced cycles of size greater than h be  represented in a host tree with maximum degree h?","palabras_clave":"intersection graphs"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39222,"idioma_id":4,"titulo":"Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster","resumen":"Aging is associated to disrupted contractility and rhythmicity, among other cardiovascular alterations. Drosophila melanogaster shows a pattern of aging similar to human beings and recapitulates the arrhythmogenic conditions found in the human heart. Moreover, the kinase CaMKII has been characterized as an important regulator of heart function and an arrhythmogenic molecule that participate in Ca2+ handling. Using a genetically engineered expressed Caindicator, we report changes in cardiac Ca2+ handling at two different ages. Aging prolonged relaxation, reduced spontaneous heart rate (HR) and increased the occurrence of arrhythmias, ectopic beats and asystoles. Alignment between Drosophila melanogaster and human CaMKII showed a high degree of conservation and indicates that relevant phosphorylation sites in humans are also present in the fruit fly. Inhibition of CaMKII by KN-93 (CaMKII-specific inhibitor), reduced HR without significant changes in other parameters. By contrast, overexpression of CaMKII increased HR and reduced arrhythmias. Moreover, it increased fluorescence amplitude, maximal rate of rise of fluorescence and reduced time to peak fluorescence. These results suggestthat CaMKII in Drosophila melanogaster acts directly on heart function and that increasing&nbsp; CaMKII expression levels could be beneficial to improve contractility.","palabras_clave":"Aging|CaMKII|arrhythmias|calcium"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39223,"idioma_id":4,"titulo":"The fit between parasites and intermediate host population dynamics: larval digeneans affecting the bivalve Neolepton cobbi (Galeommatoidea) from Patagonia","resumen":"Temporal variations in prevalence and intensity of infection of larval trematodes in their second intermediate host, the bivalve Neolepton cobbi, were studied relative to the host population dynamics and season in the intertidal zone of Patagonian rocky shores. Two larval gymnophallid metacercariae of Gymnophallidae gen. sp. and of Bartolius sp., were found parasitising N. cobbi. The parameters of infection were related to the size structure of the host population. The high values of prevalence of Gymnophallidae gen. sp. and Bartolius sp. found between late winter and early austral summer, coincided with the dominance of intermediate and larger size classes in the host population. Conversely, the lower prevalence in midsummer coincided with the dominance of small size bivalves (mean size: 0.7 ± SD: 0.1 mm length) after the turnover of the host population. For metacercariae of Gymnophallidae gen. sp., the prevalence was related positively to host size. Mean intensity of infection (mean number of metacercariae per infected individual in a sample) of Gymnophallidae gen. sp. showed no defined seasonal pattern, with more than 60 % of bivalves showing low intensities (&#8804; 5) on each sampling occasion. Intensity of infection was significantly higher in bivalves &#8805; 1.4 mm length compared to smaller sizes, but showed a tendency to decrease in bivalves &#8805; 2.4 mm length. For metacercariae of Bartolius sp., higher values of prevalence were found in bivalves with lengths between 1.4 and 2.4 mm. Prevalence was lower in larger size classes. Intensity of infection was not related to host size.","palabras_clave":"BIVALVE HOSTS|GYMNOPHALLIDAE|LARVAL TREMATODES|SEASONALITY OF INFECTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39224,"idioma_id":4,"titulo":"Tissue damage modeling in gene electrotransfer: the role of pH","resumen":"Optimal gene electrotransfer (GET) requires a compromise between maximum transgene expression and minimal tissue damage. GET in skeletal muscle can be improved by pretreatment with hyaluronidase which contributes to maximize transgene uptake and expression. Nevertheless, tissue damage remains severe close to the electrodes, with a concomitant loss of GET efficiency. Here we analyze the role of pH in tissue damage inGET protocols through in vivo modeling using a transparent chamber implanted into the dorsal skinfold of a mouse (DSC) and intravital microscopy, and in silico modeling using the Poisson?Nernst?Planck equations for ion transport. DSC intravital microscopy reveals the existence of pH fronts emerging from both electrodes and that these fronts are&nbsp; immediate and substantial thus giving rise to tissue necrosis. Theoreticalmodeling confirmsexperimental measurements and shows that in GET protocols whether with or without hyaluronidase pretreatment, pH fronts are the principal cause of muscle damage near the electrodes. It also predicts that an optimal efficiency in GET protocols, that is a compromise between obtaining maximumelectroporated area and minimal tissue damage, is achieved when the electric field applied is near 183 V\/cm in a GET protocol and 158 V\/cm in ahyaluronidase + GET protocol.","palabras_clave":"MATHEMATICAL MODELING|GENE ELECTROTRANSFER|PH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39225,"idioma_id":4,"titulo":"The gap in knowledge of clinical practice guidelines by mental health residents in Buenos Aires (Argentina)","resumen":"The aim of this pilot study was to evaluate if the residents of psychiatry and clinical psychology from the city of Buenos Aires knew any of the existing Mental Health Clinical Practice and Treatment Guidelines (CPTGs). We asked residents their opinion about CPTGs and, also, if they followed their recommendations in clinical practice. We asked 59 mental health residents (28 physicians and 29 psychologists) with different years of clinical training to fill a questionnaire to know their opinion about CPTGs and also if they follow the CPTGs recommendations in their clinical practice. We found that 79.31% of residents didn?t know any CPTG. Eighty percent of the residents who did know any CPTG have a positive opinion about CPTGs. Finally, the American Psychiatric Association Guidelines were the most known CPTG. The authors emphasize the need for a clinical guidelines diffusion policy in Buenos Aires city, and particularly as a clinical and training resource for mental health residents.","palabras_clave":"Clinical guidelines|Residents|City of Buenos Aires."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39226,"idioma_id":4,"titulo":"Historical and ecological divergence among populations of Monttea chilensis (Plantaginaceae), an endemic endangered shrub bordering the Atacama Desert, Chile","resumen":"The coastal deserts of northern Chile show an important latitudinal gradient of aridity with more arid areas to the north of the Atacama Desert than to the south. Several plant species have disjunct distributions that correspond with the extremes of this latitudinal gradient. In this study, using genetic (chloroplast and nuclear DNA), morphological (vegetative and floral traits of various kinds) and climatic and topographic information, we explored ecological and historical events that have putatively shaped patterns of variation among Monttea chilensis populations ? a species that shows this disjunct distribution. Through phylogeographic and phylogenetic analyses, two divergent lineages were identified located at the latitudinal extremes. The lineage located north (NG) of the Atacama Desert showed more genetic diversity and better-resolved phylogeographic structure than the southern (SG) lineage. Considerable morphological variation across the geographical range corresponds with these genetic groups. We observed contrasting relationships between floral and vegetative traits: populations from the most arid region (NG) possessed larger flowers, but smaller vegetative values, and vice versa. Niche modelling and multivariate analyses, including environmental data, revealed different environmental requirements for each lineage. NG plants occur in regions with warmer and drier climatic conditions and at higher altitudes, while SG populations inhabit colder and more humid environments and lower altitudes. The evolutionary history of M. chilensis exhibits a phylogeographical footprint consistent with past fragmentation and allopatric differentiation, where the hyper-arid zone formed by the Atacama Desert clearly acted as an important gene flow barrier. This barrier has led to considerable differentiation in morphology and ecology, resulting in two ecotypes or geographical races, suggesting incipient speciation promoted by local adaptation and geographical isolation.","palabras_clave":"aridization|ecological niche modelling| flower shape|vicariance|flower colour| geographic variation|plant phylogeography"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39227,"idioma_id":4,"titulo":"The buck in the milkweed: evidence of male-male interference among pollinaria on pollinators.","resumen":"Sexual selection was originally defined for animals as dependence of the mating success on competition between conspecifics over mates through physical or sensory interaction. Secondary sexual characters (SSC) were recognized as the evolutionary outcome of this kind of selection, with direct physical interaction leading to differences in fitness. Pollinaria of milkweeds may physically compete for access to attachment points on the pollinators? body, and occasionally pollinaria may link onto pre-existing pollinaria on a pollinator resulting in concatenation. We tested the hypotheses that concatenation may result in interference between proximal and distal pollinaria and that features of non- concatenating pollinaria might be attributed to prevention of concatenation, by analyzing pollen donation efficiency, experimental manipulation of the phenotype, and the phylogenetic patterns of co-occurrence of traits. It is shown that concatenation was able to diminish the reproductive performance of proximal pollinaria, that horns on pollinaria prevented concatenation, and horn acquisition was correlated with a loss of concatenation. The experimental removal of horns in species that did not concatenate reverted to concatenation. The present evidence appears to be the first of male body-body struggles in the fashion that is known in animals, and this may represent the first ever recognized SSC in plants.","palabras_clave":"SELECTION|SEXUAL|CONTEST|POLLINARIUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39228,"idioma_id":5,"titulo":"Patrones de depósito de polen sobre el cuerpo de los polinizadores en comunidades esfingófilas de argentina subtropical","resumen":"Patrones de depósito de polen sobre el cuerpo de los polinizadores en comunidades esfingófilas  de Argentina Subtropical. Las especies de plantas que coexisten y comparten agentes  polinizadores pueden experimentar competencia interespecífica por el servicio de los  polinizadores o por interferencia de polen impropio. Para evitar esto último, las especies  de plantas pueden utilizar diferentes sitios del cuerpo de los polinizadores para depositar  su polen, ya sea mediante diferentes arquitecturas florales o diferentes longitudes florales.  Evaluamos aquí la ocurrencia de este patrón de utilización diferencial de los cuerpos de  los polinizadores en diferentes comunidades esfingófilas de Argentina Subtropical (i.e.  si las plantas depositan el polen en diferentes partes del cuerpo o a diferentes alturas en la  probóscide de los esfíngidos polinizadores). Hallamos que 42 especies de plantas nativas son polinizadas por esfíngidos en Argentina Subtropical. Observamos una correlación positiva y significativa entre la distancia operativa de las flores y la longitud media de la  probóscide de los esfíngidos polinizadores. Sin embargo, tanto la diversidad promedio de  los sitios de depósito de polen como la diferencia promedio de longitud floral entre especies  de plantas esfingófilas presentes en la misma comunidad no difirieron significativamente de lo esperado bajo un modelo nulo, aunque nueve comunidades presentaron una alta  diversidad de los sitios de depósito, la cual fue significativamente mayor que lla esperada  por azar. Estos resultados sugieren que otros factores, como el grado de generalización en  la polinización, la fenología y\/o la utilización de señales florales distintivas , podrían estar  evitando la competencia por polinizadores entre especies de plantas coexistentes.","palabras_clave":"ESFÍNGIDOS|POLINIZACIÓN|POLEN|INTERFERENCIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39229,"idioma_id":4,"titulo":"Natural occurrence of entomophthoroid fungi of aphid pests  on Medicago sativa L. in Argentina","resumen":"Abstract: Four species of entomophthoroid fungi, Pandora neoaphidis (Entomophthorales:Entomophthoraceae), Zoophthora radicans (Entomophthorales: Entomophthoraceae),Entomophthora planchoniana (Entomophthorales: Entomophthoraceae) and Neozygites fresenii (Neozygitales: Neozygitaceae) were found to infect Aphis craccivora, Therioaphis trifollii, and Acyrtosiphon pisum whereas unidentified species of Acyrtosiphon were found on lucerne in Argentina. Samples were collected from fi ve sites (Ceres, Rafaela,Sarmiento, Monte Vera and Bernardo de Irigoyen) in the province of Santa Fe. In this study, Zoophthora radicans was the most important pathogen recorded on Acyrtosiphon sp., which was successfully isolated and maintained in pure cultures. This study is the first report of entomophthoroid fungi infecting lucerne (Medicago sativa L.) aphids in Argentina.","palabras_clave":"LUCERNE|APHIDS|ENTOMOPATHOGENIC|FUNGI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39230,"idioma_id":4,"titulo":"Cyclic AMP-mediated EPAC activation is involved in the regulation of adipogenic genes during 3T3-L1 fibroblasts differentiation","resumen":"Adipogenesis is stimulated in 3T3-L1 fibroblasts by a combination of insulin, dexamethasone and isobutylmethylxanthine, IBMX, (I+D+M). Two transcriptional factors are important for the acquisition of the adipocyte phenotype, C\/EBP beta (CCAT enhancer-binding protein beta) and PPAR gamma (peroxisome proliferator-activated receptor gamma). IBMX increases cAMP content, which can activate protein kinase A (PKA) and\/or EPAC (exchange protein activated by cAMP). To investigate the importance of IBMX in the differentiation mixture, we first evaluated the effect of the addition of IBMX on the increase of C\/EBP beta and PPAR gamma and found an enhancement of the amount of both proteins. IBMX addition (I+D+M) or its replacement with a cAMP analog, dibutyryl-cAMP or 8-(4-chlorophenylthio)-2-O?-methyl-cAMP (8CPT-2-Me-cAMP), the latter activates EPAC and not PKA, remarkably increased PPAR gamma mRNA. However, neither I+D nor each of the inducers alone, increased PPAR gamma mRNA to a similar extent suggesting the importance of the presence of both, IBMX and I+D. It was also found that the addition of IBMX or 8CPT-2-Me-cAMP was able to increase the content of C\/EBP beta with respect to I+D. In agreement with these findings, a microarray analysis showed that the presence of either 8CPT-2-Me-cAMP or IBMX in the differentiation mixture was able to up-regulate PPAR gamma and PPAR gamma-activated genes as well as other genes involved in lipid metabolism. Our results prove the involvement of IBMX-cAMP-EPAC in the regulation of adipogenic genes during differentiation of 3T3-L1 fibroblasts and therfore contributes to elucidate the role of cyclic AMP in this process.","palabras_clave":": 3T3-L1 CELLS|ADIPOGENESIS|C-EBP BETA|CYCLIC-AMP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39231,"idioma_id":4,"titulo":"Glycerol-3-phosphate  acyltranferase-2  behaves  as  a  cancer  testis  gene  and  promotes  growth  and tumorigenicity of the breast cancer MDA-MB-231 cell line","resumen":"The de novo synthesis of glycerolipids in mammalian cells begins with the acylation of glycerol-3-phosphate, catalyzed by glycerol-3-phosphate acyltransferase (GPAT). GPAT2 is a mitochondrial isoform primarily expressed in testis under physiological conditions. Because it is aberrantly expressed in multiple myeloma, it has been proposed as a novel cancer testis gene. Using a bioinformatics approach, we foundthat GPAT2 is highly expressed in melanoma, lung, prostate and breast cancer, and we validated GPAT2 expression at the protein level in breast cancer by immunohistochemistry. In this case GPAT2 expression correlated with a higher histological grade. 5-Aza-2´deoxycytidine treatment of human cells lines induced GPAT2 expression suggesting epigenetic regulation of gene expression. In order to evaluate the contribution of GPAT2 to the tumor phenotype, we silenced its expressionin MDA-MB-231 cells. GPAT2 knockdown diminished cell proliferation, anchorage independent growth, migration and tumorigenicity, and increased staurosporine-induced apoptosis. In contrast, GPAT2 over-expression increased cell proliferation rate and resistance to staurosporine-induced apoptosis. To understand the functionalrole of GPAT2, we performed a co-expression analysis in mouse and human testis and found a significant association with semantic terms involved in cell cycle, DNA integrity maintenance, piRNA biogenesis and epigenetic regulation. Overall, these results indicate the GPAT2 would be directly associated with the control of cell proliferation. In conclusion, we confirm GPAT2 as a cancer testis gene and that its expression contributes to the tumor phenotype of MDA-MB-231 cells.","palabras_clave":"GPAT2|APOPTOSIS|BREAST|CANCER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39232,"idioma_id":4,"titulo":"Furan resins as replacement of phenolic protective coatings: Structural, mechanical and functional characterization","resumen":"Phenolic coatings are usually a convenient and economical way to protect metallic materials against wearand corrosion. Furan resins are analogous to phenolics, as they are obtained by replacing formaldehydeby furfural in their formulation. In this work, a furan resin based on furfural and phenol was synthesizedand used as an aluminum coating. Thus, toxic emissions of formaldehyde were avoided, while a biobasedderivative was used instead. The performance of the proposed resin was compared with the one of atraditional phenolic resin. Physicochemical characteristics including chemical structure, surface polarityand glass transition temperature were evaluated by means of Fourier transform infrared spectroscopy,contact angle measurements and dynamic?mechanical analysis, respectively. Nanomechanical and nan-otribological properties were assessed by depth sensing indentation techniques. As well, the corrosionresistance of the furan coating was determined by potentiodynamic polarization tests. The obtainedresults validate the furan resin as a feasible alternative to phenolics to protect aluminum.","palabras_clave":"Organic coatings|Phenolic resin|Furan Resin|Nanoindetation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39233,"idioma_id":5,"titulo":"La oferta de educación primaria y la trayectoria de los estudiantes en la Ciudad de Buenos Aires: logros de la última década y persistencia de desigualdades","resumen":"    El  artículo ofrece una caracterización de la educación primaria en la Ciudad Autónoma de  Buenos Aires que aspira a determinar la situación actual de esta oferta  educativa, las principales tendencias registradas durante la última década y  las relaciones que se establecen entre los datos educativos y el perfil  socioeconómico y demográfico de la población. Para ello se analiza, desde una  perspectiva fundamentalmente cuantitativa, el comportamiento de un conjunto de  indicadores referidos a la cobertura del nivel y a los alumnos y sus  trayectorias escolares, a la luz de ciertos factores específicos del sistema  educativo (sector de gestión, tipo de jornada) como también de factores  territoriales (comunas y zonas).  ","palabras_clave":"EDUCACION PRIMARIA|OFERTA EDUCATIVA|TRAYECTORIAS ESCOLARES|COMUNAS Y ZONAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39234,"idioma_id":4,"titulo":"Bromopyrrole Alkaloids Isolated from the Patagonian Bryozoan Aspidostoma giganteum","resumen":"Nine new bromopyrrole alkaloids, aspidostomides A-H and aspidazide A (1-9), were isolated from the Patagonian bryozoan Aspidostoma giganteum. Aspidostomides A-H have dibromotyrosine or bromotryptophan-derived moieties forming either linear amides or pyrroloketopiperazine-type lactams with a bromopyrrole carboxylic acid as a common structural motif. On the other hand, aspidazide A is a rare asymmetric acyl azide formed by an N-N link of two different pyrroloketopiperazine lactams, and is the first isolated compound of this class from marine invertebrates. This work is the first report of secondary metabolites isolated from a bryozoan from the Patagonian region. The structures of compounds 1-9 were elucidated by spectroscopic methods and chemical transformations. One of these compounds, aspidostomide E (5) was moderately active against the 786-O renal carcinoma cell line.","palabras_clave":"ASPIDOSTOMA GIGANTEUM|MARINE NATURAL PRODUCTS|BRYOZOAN|ALKALOIDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39235,"idioma_id":4,"titulo":"Regulation of PKA activity by an auto-phosphorylation mechanism in Saccharomyces cerevisiae.","resumen":"The cAMP dependent Protein Kinase activity, as well as other AGC members, is regulated by multiple phosphorylations of its catalytic subunits. In Saccharomyces cerevisiae PKA regulatory subunit is encoded by the gene BCY1, and the catalytic subunits are encoded by three genes: TPK1, TPK2 and TPK3. Previously we have reported that following cAMP-PKA pathway activation, Tpk1 increases its phosphorylation status. Now, in vivo genetic and in vitro experiments indicate an autophosphorylation mechanism for Tpk1. Using array peptides derived from Tpk1 we identified Ser179 as a target residue. Tpk1 is phosphorylated on Ser179 in vivo during glucose stimulus. Reduction of the activation loop Thr241 phosphorylation increases Ser179 autophosphorylation. To evaluate the role of phosphorylation on Ser179 we made strains expressing tpk1S179A or tpk1S179D as sole PKA kinase source. Our results suggest that Ser179 phosphorylation increases the reactivity towards the substrate without affecting the formation of the holoenzyme. Phenotypic readouts analysis showed that Ser179 phosphorylation increases in vivo PKA activity reducing cell survival, stress and life span. Ser179 phosphorylation increases Tpk1 cytoplasmic accumulation in glucose-growing cells. These results describe for the first time that an autophosphorylation mechanism on Tpk1 controls PKA activity in response to glucose availability.","palabras_clave":"PKA|TPK1|PHOSPHORYLATION|SACCHAROMYCES CEREVISIAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39236,"idioma_id":4,"titulo":"Degradation of trimethylamine by immobilized cells of Pseudomonas putida A (ATCC 12633)","resumen":"The Pseudomonas putida A (ATCC 12633) capable of degrading trimethylamine (TMA) was immobilized in calcium alginate. The TMA-degrading capacity of immobilized cells was compared to free cells in batch culture by changing temperature, pH, nutrient supplementation, and initial TMA concentration. Although the immobilized cells show good removal efficiencies in wider ranges of temperature (15 °C?35 °C) and pH (6.5?8.5) than free cells, the optimum conditions for TMA removal for both free and immobilized cells were 30 °C, in buffered medium (pH 7.5) without addition of nutrients. Immobilized cells degraded up 885 mg l-1 of TMA completely whereas the free cells degraded only 295 mg l-1. For all the TMA concentrations evaluated with immobilized cells (295 to 885 mg l-1), after 24 h, the degradation rate started to decline. This effect was attributed to the accumulation of intracellular TMA into the cells (8.3 to 15.3 mg l-1) which is sufficient to inhibit the first enzyme of the aerobic degradation of TMA by P. putida, the TMA dehydrogenase. The fact that the immobilized cells showed a high stability as regards their viability and degradability of high TMA concentrations revealed a good potential of this system for treating of TMA-contaminated site.","palabras_clave":"TRIMETHYLAMINE|PSEUDOMONAS PUTIDA|BIODEGRADATION|ALGINATE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39237,"idioma_id":4,"titulo":"The \ttadpole of Odontophrynus barrioi Cei, Ruiz, and Beçak, 1982 (Anura: \tOdontophrynidae): a comparison with the other tadpoles of the genus.","resumen":"We describe the tadpole of Odontophrynus barrioi including external larval features, chondrocranial and cranial musculature, and compare it with the other species of the genus. Tadpoles of O. barrioi at stages 31?37 are about 52.46 mm long. The body is slightly depressed in lateral view and ovoid in dorsal view. Oral disc is emarginate laterally, anteroventral and small with a single row of marginal papillae, a single large dorsal gap, and labial tooth row formula 2(2)\/3(1). Despite small interspecific variations, like different labial tooth row formulae, the general aspect of species is quite similar. Although poorly-known yet, the chondrocranium and cranial musculature display some variations within the genus.","palabras_clave":"CHONDROCRANIUM|CRANIAL MUSCLES|EXTERNAL MORPHOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39238,"idioma_id":5,"titulo":"VARIABILIDAD GENÉTICA MITOCONDRIAL: COMPARACIÓN DE  MUESTRAS DE DOS SITIOS ARQUEOLÓGICOS DEL NOROESTE  ARGENTINO","resumen":"RESUMEN Pampa Grande (PG) y Los Amarillos (LA) son dos sitios arqueológicos del noroeste argentino (NOA), en los que el estudio de ADN antiguo ha permitido determinarel sexo de los individuos y analizar los linajes paternos y maternos presentes. PG (Salta) se ha adjudicado al Periodo Formativo y LA ubicado en la Quebrada de Humahuaca (Jujuy), habría tenido una masiva ocupación hacia el Período de Desarrollos Regionales. El objetivo de este trabajo es comparar ambos sitios en cuanto a su diversidad genética analizando los haplogrupos y haplotipos de ADN mitocondrial estudiados en dichas poblaciones. Se incluyeron en el análisis 19 individuos de PG y 18 de LA. Al analizar loslinajes mitocondriales, se observa que los únicos haplogrupos compartidos entre ambas poblaciones son los haplogrupos A2 y D1, encontrados habitualmente en poblacionesamerindias. Por otro lado, no se detectó el haplogrupo B2 en LA, ni el C1 en PG. Los análisis de variación génica realizados a partir de la Región Hipervariable I indican unadiferenciación genética significativa entre ambos sitios, siendo PG el más variable. Mecanismos microevolutivos asociados a la distancia geográfica y temporal parecen habermoldeado la diversidad intra e interpoblacional entre estos dos sitios prehispánicos del NOA. Rev Arg Antrop Biol 16(1):05-16, 2014.","palabras_clave":"ADN antiguo|diversidad mitocondrial|Pampa Grande|Los Amarillos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39239,"idioma_id":4,"titulo":"Morphology and physiology of the olfactory system of blood-feeding insects","resumen":"Several blood-feeding (hematophagous) insects are vectors of a number of diseases including dengue, Chagas disease and leishmaniasis which persistently affect public health throughout Latin America. The vectors of those diseases include mosquitoes, triatomine bugs and sandflies. As vector control is an efficient way to prevent these illnesses it is important to understand the sensory biology of those harmful insects. We study the physiology of the olfactory system of those insects and apply that knowledge on the development of methods to manipulate their behavior. Here we review some of the latest information on insect olfaction with emphasis on hematophagous insects. The insect olfactory sensory neurons are housed inside hair-like organs called sensilla which are mainly distributed on the antenna and mouthparts. The identity of many of the odor compounds that those neurons detect are already known in hematophagous insects. They include several constituents of host (vertebrate) odor, sex, aggregation and alarm pheromones, and compounds related to egg-deposition behavior. Recent work has contributed significant knowledge on how odor information is processed in the insect first odor-processing center in the brain, the antennal lobe. The quality, quantity, and temporal features of the odor stimuli are encoded by the neural networks of the antennal lobe. Information regarding odor mixtures is also encoded. While natural mixtures evoke strong responses, synthetic mixtures that deviate from their natural counterparts in terms of key constituents or proportions of those constituents evoke weaker responses. The processing of olfactory information is largely unexplored in hematophagous insects. However, many aspects of their olfactory behavior are known. As in other insects, responses to relevant single odor compounds are weak while natural mixtures evoke strong responses. Future challenges include studying how information about odor mixtures is processed in their brain. This could help develop highly attractive synthetic odor blends to lure them into traps","palabras_clave":"INSECT OLFACTION|HEMATOPHAGOUS INSECTS|DISEASE VECTORS|OLFACTORY SENSILLA;|ANTENNAL LOBE|ODOR MIXTURES|ODOR DETECTION|ODOR CODING|OLFACTORY BEHAVIOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39240,"idioma_id":4,"titulo":"Effect of support on the deep oxidation of propane and propylene on Pt-based catalysts","resumen":"The complete oxidations of propane and propylene were studied on Pt supported on CeO2, TiO2 and Al2O3. The catalyst activities were evaluated through conversion versus temperature (light-off curves) and conversion versus time tests. Propane oxidation turnover rates (TOF) followed the order: Pt\/TiO2 &gt; Pt\/CeO2 &gt; Pt\/Al2O3. The higher activity on Pt\/CeO2 than on Pt\/Al2O3 was interpreted by considering that the combustion of C3H8 on Pt\/CeO2 occurs not only on Pt0 sites but also on perimeter Pt0-Ce+3 sites providing an additional oxidation pathway. Propane uptake on Pt\/TiO2 was 5.5 times higher than on Pt\/CeO2. This drastic increase of the density of adsorbed C3H8 molecules around the metallic Pt active sites would explain the high TOF values observed on Pt\/TiO2 because the reaction is positive order with respect to propane. The propylene oxidation turnover rate trend was Pt\/CeO2 &gt; Pt\/Al2O3 ?° Pt\/TiO2. Kinetic studies showed that on the three catalysts the apparent activation energy of propylene oxidation was about the same while the reaction orders were positive in oxygen and negative or zero in propylene. The higher activity of Pt\/CeO2 catalyst was explained by considering that the Pt-catalyzed reduction of ceria forms oxygen vacancies that would improve the mobility of lattice oxygen of the support and its transfer to the propylene species adsorbed on the metal.","palabras_clave":"Propane oxidation|Propylene oxidation|Hydrocarbon combustion|Environmental catalysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39241,"idioma_id":4,"titulo":"A new species of Pseudocrepidobothrium (Cestoda: Proteocephalidea), from Pseudoplatystoma fasciatum (Pisces: Siluriformes) in the Paraná River basin (Argentina)","resumen":"This study describes the proteocephalidean tapeworm Pseudocrepidobothrium chanaorum sp. n. (Proteocephalidae: Proteocephalinae), which was found in the intestine of the barred sorubim Pseudoplatystoma fasciatum (Linnaeus) from the Colastiné River, a tributary of the Paraná River. The new species differs from the two other species of the genus, P. eirasi (Rego et de Chambrier, 1995) and P. ludovici Ruedi et de Chambrier, 2012, parasites of Phractocephalus hemioliopterus (Bloch et Schneider) from the Amazon River in Brazil, in having fewer proglottides (4?8 without ventral appendages vs. 7?12 with ventral appendages and 20?36 without ventral appendages, respectively), a smaller scolex (350?450 wide vs. 495?990 and 515?1 020 wide, respectively), in the total number of testes (21?25 vs. 21?51 and 37?79, respectively), a cirrus-sac usually anteriorly directed when the vagina is posterior to cirrus-sac vs. transversely situated in the known species.. The study of the tegumental surface of Pseudocrepidobothrium spp. revealed the presence of four types of microtriches: papilliform, acicular and capilliform filitriches, and gladiate spinitriches. The three species have a similar microthrix pattern, with minor differences on the immature proglottis surface. Pseudocrepidobothrium chanaorum sp. n. is the ninth proteocephalid reported from P. fasciatum.","palabras_clave":"PROTEOCEPHALINAE|TAXONOMY|MORPHOLOGY|MICROTHRIX PATTERN|PSEUDOCREPIDOBOTHRIUM CHANAORUM|SURUBI ATIGRADO|SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39242,"idioma_id":4,"titulo":"Average dynamics of a finite set of coupled phase oscillators","resumen":"We study the solutions of a dynamical system describing the average activity of an infinitely large set of driven coupled excitable units. We compared their topological organization with that reconstructed from the numerical integration of finite sets. In this way, we present a strategy to establish the pertinence of approximating the dynamics of finite sets of coupled nonlinear units by the dynamics of its infinitely large surrogate.","palabras_clave":"chaos|phase oscillators|mean field|bifurcations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39243,"idioma_id":4,"titulo":"Heterogeneities in the eco-epidemiology of Trypanosoma cruzi infection in rural communities of the Argentinean Chaco","resumen":"We conducted a cross-sectional survey of Trypanosoma cruzi infection of   Triatoma infestans as well as dogs and cats in 327 households from a   well-defined rural area in northeastern Argentina to test whether the   household distribution of infection differed between local ethnic groups   (Tobas and Creoles) and identify risk factors for host infection.   Overall prevalence of infection of bugs (27.2%; 95% confidence interval =   25.3-29.3%), dogs (26.0%; 95% confidence interval = 23.3-30.1%), and   cats examined (28.7%; 95% confidence interval = 20.2-39.0%) was similar.   A multimodel inference approach showed that infection in dogs was   associated strongly with the intensity and duration of local exposure to   infected bugs and moderately with household ethnic background. Overall,   Toba households were at a substantially greater risk of infection than   Creole households. The strong heterogeneities in the distribution of   bug, dog, and cat infections at household, village, and ethnic group   levels may be used for targeted vector and disease control.","palabras_clave":"GRAN CHACO|TRIATOMINAE BUGS|CHAGAS DISEASE|TRYPANOSOMA CRUZI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39244,"idioma_id":4,"titulo":"Characterization of Hg-phytochelatins complexes in vines (Vitis vinifera cv Malbec) as defense mechanism against metal stress","resumen":"An approach to understand vines (Vitis vinifera) defense mechanism against heavy metal stress by isolation and determination of Hg-phytochelatins (PCs) complexes was performed. PCs are important molecules involved in the control of metal concentration in plants. PCs complex toxic metals through &#8722;SH groups and stores them inside cells vacuole avoiding any toxic effect of free metals in the cytosol. The Hg-PCs identification was achieved by determination of Hg and S as hetero-tagged atoms. A method involving two-dimensional chromatographic analysis coupled to atomic spectrometry and confirmation by tandem mass spectrometry is proposed. An approach involving size exclusion chromatography coupled to inductively coupled plasma mass spectrometry on roots, stems, and leaves extracts describing Hg distribution according to molecular weight and sulfur associations is proposed for the first time. Medium?low molecular weight Hg?S associations of 29?100 kDa were found, suggesting PCs presence. A second approach employing reversed-phase chromatography coupled to atomic fluorescence spectrometry analysis allowed the determination of Hg-PCs complexes within the mentioned fractions. Chromatograms showed Hg-PC2, Hg-PC3 and Hg-PC4 presence only in roots. Hg-PCs presence in roots was confirmed by ESI?MS\/MS analysis.","palabras_clave":"Vitis vinifera|Mercury|Phytochelatins|Metal stress"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39245,"idioma_id":4,"titulo":"Use of grape pomaces to produce biomass of a Komagataella pastoris strain expressing a bovine chymosin activity","resumen":"The use of agro-industrial wastesnot only decreases bioprocesses and disposal costs but also contributes to theupgrading of the residues. An active recombinant methanol-inducible bovinechymosin has been expressed in our laboratory in the yeast Komagataella pastoris, andgrape pomaces extracts (GRE) were proposed as a convenient C-energy source forthe biomass production of the genetically engineered strain.Carbon and nitrogen sources, growthfactors and initial pH conditions were selected by classical methodology;thereafter, growth conditions optimization was performed using StatisticalDesigned Experiments (DoEs). In the presence of (g L-1): 67.0monosaccharides (glucose and fructose) from GRE; 5.0 (NH4)2SO4and 10.0 sugar cane molasses (CMz), a yield of 20.0 g L-1 celldry weight (CDW) was obtained aerobically after 60 h incubation at 28ºC and pH 4.0. Applying afed-batch strategy with methanol:sorbitol as the enzyme inducers, a chymosinproduction of 8.53 International-Milk-Clotting-Units (IMCU) per mg protein wasobtained in the supernatant.The results presented show thatthrough a statistical design, a simple, cheap and easy to prepare culturemedium could be developed using two agroindustrial derivatives (GRE and CMz) toobtain a higher value added product.","palabras_clave":"KOMAGATAELLA PASTORIS  BIOMASS |BOVINE CHYMOSIN| AGRO-ÍNDUSTRIAL  BY-PRODUCT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39246,"idioma_id":4,"titulo":"Mycotoxins from Beehive Pollen Mycoflora","resumen":"Aims: The present study was aimed to search for metabolites produced by fungal strains with antifungal activity against phytopathogens.  Study Design: The polen of four behives each from two apiaries from two locations in Argentina (Balcarce and Mar del Plata) was studied. Nine be polen samples were randomly colected from each behive.  Place and Duration of Study: Study was undertaken during 201 on the Organic  Chemistry Department and Biodiversity and Experimental Biology Department, Schol of Exact and Natural Sciences, University of Buenos Aires.  Methodology: Al of the 13 isolated strains were tested for antifungal activity. The most bioactive strains, Myrothecium verucaria, Nigrospora sphaerica and a levuliform mycelia, were selected for the isolation and identifcation of compounds responsible for the antifungal activity.  Results: Seven mycotoxins, roridin A, verucarin A, &#945;-&#946;-dehydrocurvularin, phomalactones A, B, C and D, were identifed spectroscopicaly and were the responsible the antifungal activity.  Conclusion: Mycotoxins were isolated from behive polen mycoflora. This is the first report of the production of these mycotoxins, which are not curently targets for the analysis of polen or honey products.","palabras_clave":"micotoxinas|tricotecenos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39247,"idioma_id":4,"titulo":"CD207(+) cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo\/Nec vaccine in mice","resumen":"De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic\/necrotic cells (Apo\/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6?10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(&#8722;) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question.","palabras_clave":"células dendríticas dérmicas|vacuna antitumoral|infiltrado inflamatorio|estructura linfoide terciaria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39248,"idioma_id":4,"titulo":"Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1","resumen":"Immune evasion strategies are important for the onset and the maintenance of viral infections. Many viruses have evolved mechanisms to counteract or suppress the host immune response. We have previously characterized two syncytial (syn) variants of Herpes simplex 1 (HSV-1) strain F, syn14-1 and syn17-2, obtained by selective pressure with a natural carrageenan. These variants showed a differential pathology in vaginal and respiratory mucosa infection in comparison with parental strain. In this paper, we evaluated the modulation of immune response in respiratory mucosa by these HSV-1 variants. We observed altered levels of Tumor Necrosis Factor-&#945; and Interleukin-6 in lungs of animals infected with the syn14-1 and syn17-2 variants compared with the parental strain. Also, we detected differences in the recruitment of immune cells to the lung in syn variants infected mice. Both variants exhibit one point mutation in the sequence of the gene of glycoprotein D detected in the ectodomain of syn14-1 and the cytoplasmic tail of syn17-2. Results obtained in the present study contribute to the characterization of HSV-1 syn variants and the participation of the cellular inflammatory response in viral pathogenesis.","palabras_clave":"cytokines|herpes simplex virus tipo-1|variantes virales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39249,"idioma_id":4,"titulo":"Ni(II)-Mg(II)-Al(III) catalysts for hydrogen production from ethanol steam reforming: Influence of the Mg content","resumen":"uring the last centuries, human civilization has solved the energy supply problem mainly on the  bases of fossil sources of carbon and hydrocarbons and the associated technologies. In the last  three decades there have been growing concerns about the shortage in energy supply in the world  [1], which triggered the searching for alternative sources and technologies. Most of the chemical  based alternatives consider hydrogen as an efficient energetic vector since it directly transforms  chemical energy into electric current by means of fuel cells technology, releasing steam as the only  product. However, hydrogen non-contaminant character depends on the nature of the raw material  used as source. In this sense, steam reforming of ethanol, obtained from biomass, offers a true  green alternative for H2 production, due to its inherent renewable character, low toxicity (unlike  methanol) and the fact that it can be obtained virtually sulphide-free [2,3]. Ethanol has relatively  high hydrogen content and in presence of water, is capable of producing 6 mol of H2 per mol of  ethanol:  C2H5OH + 3H2O &#8594; 2CO2+ 6H2(1)","palabras_clave":"LDH|Catalysis|Ethanol steam reforming|green hydrogen"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39250,"idioma_id":4,"titulo":"Multicomponent synthesis of 4,4-dimethyl sterol analogues and their effect on eukaryotic cells","resumen":"Most sterols, such as cholesterol and ergosterol, become functional only after the   removal of the two methyl groups at C-4 from their biosynthetic precursors.   Nevertheless, some findings suggest that 4,4-dimethyl sterols might be involved in   specific physiological processes. In this paper we present the synthesis of a collection   of analogues of 4,4-dimethyl sterols with a diamide side chain and a preliminary   analysis of their in vitro activity on selected biological systems. The key step for the   synthesis involves an Ugi condensation, a versatile multicomponent reaction. Some of   the new compounds showed antifungal and cytotoxic activity.","palabras_clave":"4,4-DIMETILESTEROLES|REACCIÓN DE UGI|ANTIFUNGICOS|CITOTOXICOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39251,"idioma_id":4,"titulo":"Personalized architectural documentation based on stakeholders' information needs","resumen":"The stakeholders of a software system are, to a greater or lesser extent,  concerned about its software architecture, as an essential artifact for capturing the key design decisions of the system. The architecture is normally documented in the Software Architecture Document (SAD), which tends to be a large and complex technical description, and does not always address the information needs of every stakeholder. Individual stakeholders are interested in dierent, sometimes overlapping, subsets of the SAD and they also require varying levels of detail. As a consequence, stakeholders are aected by an information overload problem, which in practice discourages the usage of the architectural knowledge and diminishes its value for the organization. Along this line, this work presents a semi-automated approach to recommend relevant contents of a given SAD to specific stakeholder profiles. Our approach assumes that SADs are hosted in Wikis, which not only favor communication and interactions among stakeholders, but also enable us to apply User Profiling techniques to infer stakeholders´ interests with respect to particular documents. We have built a recommendation tool implementing our approach, which was tested in two experiments with Wiki-based SADs. Although preliminary, the results have shown that the recommendations of the tool help to nd the architectural documents that best match the stakeholders´ interests.","palabras_clave":"Stakeholders|Architecture documentation|Personalization|Wikis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39252,"idioma_id":5,"titulo":"Misterios cotidianos: sobre las novelas policiales más vendidas","resumen":"El artículo rastrea el éxito de la novela policial en la literatura argneitna del siglo XXI. A partir del análisis de las listas de 'los más vendidos' de dos de los diarios de mayor circulación se analiza el modo en el cual se construye la imagen del éxito editorialy se postulan hipótesis sobre los motivos por los cuales ha crecido el éxito del gé.ero.","palabras_clave":"Policial|Contemporaneidad|Literatura argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39253,"idioma_id":4,"titulo":"Producing Just Enough Documentation: The Next SAD Version Problem","resumen":"Software architecture knowledge is an important asset in today?s projects, as it serves to share the main design decisions among the project stakeholders. Architectural knowledge is commonly captured by the Software Architecture Document (SAD), an artifact that is useful but can also be costly to produce and maintain. In practice, the SAD often fails to fulfill its mission of addressing the stakeholders? information needs, due to factors such as: detailed or high-level contents that do not consider all stakeholders, outdated documentation, or documentation generated late in the lifecycle, among others. To alleviate this problem, we propose a documentation strategy that seeks to balance the stakeholders? interests in the SAD against the efforts of producing it. Our strategy is cast as an optimization problem called ?the next SAD version problem? (NSVP) and several search-based techniques for it are discussed. A preliminary evaluation of our approach has shown its potential for exploring cost-benefit tradeoffs in documentation production.","palabras_clave":"ARCHITECTURE DOCUMENTATION MODEL|STAKEHOLDERS|INFORMATION NEEDS|COMBINATORIAL OPTIMIZATION|SEARCH-BASED TECHNIQUES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39254,"idioma_id":4,"titulo":"Interconnection and damping assignment control of a three-phase front end converter","resumen":"A new nonlinear control strategy for a three-phase front end converter used to connect renewable energy sources to the grid is proposed in this paper. The controller is designed in order to inject all the generated power into the grid, while the reactive power can be controlled to meet the power system requirements. The system is represented through its port controlled Hamiltonian model, and the controller is designed by interconnection and damping assignment. This design method allows an intuitive way to remove the undesired couplings between system dynamics while assigning the damping required to achieve the expected convergence rate. The proposed controller allows a direct control of the DC link voltage by proper selection of the controller parameters. Moreover, an integral action is added to the proposed controller in order to eliminate the steady-state error in the system variables. The proposal is validated through simulation tests performed using a realistic converter model.","palabras_clave":"Front end Converter|Nonlinear control|Passivity based control"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39255,"idioma_id":4,"titulo":"Cationic porphyrin derivatives for application in photodynamic therapy of cancer","resumen":"Current studies in photodynamic therapy (PDT) against cancer are focused on the development of new photosensitizers (PSs), with higher phototoxic action. The aim of this study was to compare the therapeutic e&#64257;ciency of tricationic meso substituted porphyrin derivatives (Tri-PyC Me -PF, Tri-PyC Me -Ph, Tri-PyC Me -CO2Me and Tri-PyC Me -COH) with the well-known tetra-cationic TPM. The phototoxic action of these derivatives was assessed in human colon adenocarcinoma cells by cell viability, intracellular localization and nuclear morphology analysis. In the experimental conditions used we determined that after light activation -PF, -Ph and -CO4Me cause a more signi&#64257;cant decline of cell viability compared to -CO2H and T4PM. These results suggest that the nature of the peripheral substituent in&#64258;uences the extent of cell photodamage. Moreover, we have demonstrated that PS concentration, physicochemical properties and further light activation determine the PDT response. All porphyrins were clearly localized as a punctuated pattern in the cytoplasm of the cells, and the PDT scheme resulted in apoptotic cell death after 3 h post-PDT. The tri-cationic porphyrin derivatives Tri-PyC Me-PF, Tri-PyC Me-Ph and Tri-PyC Me-COMe showed a promising ability, making them good photosensitizer candidates for oncological PDT.","palabras_clave":"PDT|cancer|cationic porphyrin|apoptosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39256,"idioma_id":4,"titulo":"Cellular intrinsic factors involved in the resistance of squamous cell carcinoma to photodynamic therapy","resumen":"Photodynamic therapy (PDT) is widely used to treat non-melanoma skin cancer. However, some patients affected with squamous cell carcinoma (SCC) did not respond adequately to PDT with methyl-&#948;-aminolevulinic acid (MAL-PDT) and the tumors acquired an infiltrative phenotype and became histologically more aggressive, less differentiated and more fibroblastic.  To search for potential factors implicated in SCC resistance to PDT, we have used the SCC-13 cell line (Parental) and resistant SCC-13 cells, obtained by repeated MAL-PDT treatments (5th and 10th PDT-generations). Xenografts assays in immunodeficient mice showed that the tumors generated by resistant cells were bigger than those induced by Parental cells. Comparative genomic hybridization array (aCGH) showed that the three cell types presented amplicons in 3p12.1 CADM2, 7p11.2 EFGR and 11q13.3 CCND1 genes. 5th and 10th PDT-resistant cells showed an amplicon in 5q11.2 MAP3K1 not present in Parental cells. The changes detected by aCGH on CCND1, EFGR and MAP3K1 were confirmed in extracts of SCC-13 cells by RT-PCR and by Western blot, and by immunohistochemistry in human biopsies from persistent tumors after MAL-PDT. Our data suggest that genomic imbalances related to CCND1, EFGR and particularly MAP3K1 seem to be involved in the development of resistance to PDT of SCC.","palabras_clave":"PHOTODYNAMIC THERAPY|NON MELANOMA SKIN CANCER|SQUAMOUS CELL CARCINOMA|RESISTANCE TO PDT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39257,"idioma_id":4,"titulo":"Dynamical energy transfer in ac driven quantum systems","resumen":"We analyze the time-dependent energy and heat flows in a resonant level coupled to a fermionic      continuum.  The level is periodically forced with an external power source that supplies energy      into the system. Based on the tunneling Hamiltonian approach and scattering theory, we discuss the different contributions to the total energy flux.  We then derive the appropriate expression      for the dynamical dissipation, in accordance with the fundamental principles of thermodynamics.      Remarkably, we find that the dissipated heat can be expressed as a Joule law with a universal resistence that is constant at all times.","palabras_clave":"Heat|Quantum|Transport|dynamical"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39258,"idioma_id":4,"titulo":"Mesoscopic features in the transport properties of a Kondo-correlated quantum dot in a magnetic field","resumen":"We study the transport behavior induced by a small bias voltage through a quantum dot connected to one-channel finite-size wires. We describe the quantum dot using the Hubbard?Anderson impurity model and we obtain solutions by means of a quantum MonteCarlo method. We investigate the effect of a magnetic field applied at the quantum dot in the Kondo regime. We identify mesoscopic oscillations in the conductance, which are introduced by the magnetic field. This behavior is analogous to that observed as a function of thetemperature.","palabras_clave":"Quantum|Transport|correlations|mesoscopic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39259,"idioma_id":4,"titulo":"ENVIRONMENTAL CHANGE OVER THE LAST MILLENNIUM RECORDED IN THE CAFAYATE DUNE FIELD (NW ARGENTINA)","resumen":"The Cafayate depression is a dry valley located in the Preandean region of northwest Argentina. The palaeoenvironmental significance over the last millennium of a large dune field has been established from geomorphological evidence, mineralogical, and grain shape characteristics, as well as chronological data (OSL dating, archaeological remains and historical data). The sands of the  Cafayate dune field are mineralogically young. Subangular grain shapes and surface mechanical features indicate a short transport process. Aeolian dynamics in the study area appear sensitive to  centennial climate changes and suggest four stages of dune activity: 1000-1100 AD (related to the Medieval Warm Anomaly); 1300-1420 AD; 1540-1650 AD; and 1740-1830 AD (inside the Little Ice Age). A close relationship has been established between dry periods of dune reactivation and warm regional ENSO events. In addition, human action on land use must be considered as a complementary factor affecting aeolian dynamics during the most recent stage. These results provide a new advance in our understanding of environmental changes over the last millennium in the South American drylands.","palabras_clave":"Aeolian dynamics|OSL dating|ENSO|NW Argentina drylands"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39260,"idioma_id":4,"titulo":"EFFECT OF SEX CHROMOSOME COMPLEMENT ON SODIUM APPETITE AND FOS IMMUNOREACTIVITY INDUCED BY SODIUM DEPLETION","resumen":"            Dadam FM, Caeiro XE, Cisternas CD, Macchione AF, Cambiasso            MJ, Vivas L. Effect of sex chromosome complement on sodium appetite            and Fos-immunoreactivity induced by sodium depletion. Am J Physiol            Regul Integr Comp Physiol 306: R000?R000, 2014. First published            November 20, 2013; doi:10.1152\/ajpregu.00447.2013.?Previous studies            indicate a sex chromosome complement (SCC) effect on the            angiotensin II sexually dimorphic, hypertensive, and bradycardic            baroreflex responses. We sought to evaluate whether SCC may differentially            modulate sexually dimorphic-induced sodium appetite and            specific brain activity due to physiological stimulation of the rennin            angiotensin system. For this purpose, we used the ?four core genotypes?            mouse model, in which the effect of gonadal sex and SCC is            dissociated, allowing comparisons of sexually dimorphic traits between            XX and XY females as well as in XX and XY males.            Gonadectomized mice were sodium depleted by furosemide (50            mg\/kg) and low-sodium diet treatment; control groups were administered            the vehicle and maintained on normal sodium diet. Twenty-one            hours later, the mice were divided into two groups: one group was            submitted to the water-NaCl 2% choice intake test, while the other            group was perfused and their brains subjected to the Fos-immunoreactivity            (FOS-ir) procedure. Sodium depletion, regardless of genetic            sex (XX or XY), induced a significantly lower sodium and water            intake in females than in males, confirming the existence in mice of            sexual dimorphism in sodium appetite and the organizational involvement            of gonadal steroids. Moreover, our results demonstrate a SCC            effect on induced brain FOS-ir, showing increased brain activity in            XX-SCC mice at the paraventricular nucleus, nucleus of the solitary            tract, and lateral parabrachial nucleus, as well as an XX-SCC augmented            effect on sodium depletion-induced brain activity at two            circumventricular organs, the subfornical organ and area postrema,            nuclei closely involved in fluid and blood pressure homeostasis.","palabras_clave":"sex chromosome complement|sexual dimorphism|Fos immunoreactivity|induced sodium intake"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39261,"idioma_id":4,"titulo":"Cytogenetic analysis on geographically distant parthenogenetic populations of Tityus trivittatus Kraepelin, 1898 (Scorpiones, Buthidae): karyotype, constitutive heterochromatin and rDNA localization","resumen":"Tityus trivittatus Kraepelin, 1898 is the most medically important scorpion species of Argentina, and parthenogenetic populations are present in the major cities of this country. We performed a detailed cytogenetic analysis of specimens of three synanthropic parthenogenetic populations, all distant about 900 km from each other, using Ag-NOR, C-banding, DAPI\/CMA3 staining and FISH with autologous 28S rDNA probes. The karyotype of females and embryos from the three populations showed 2n=6, with two large and four middle-sized holokinetic chromosomes. Constitutive heterochromatin was found in terminal and interstitial location and its pattern allowed the identification of three chromosome pairs. NORs were found on the terminal heterochromatic region of one pair of middle-sized chromosomes. The use of fluorochromes to characterize heterochromatin showed the absence of GC-rich heterochromatin and a low and variable number of AT-rich heterochromatic regions. We propose that a possible explanation for the lack of karyotypic variation between these geographically distant populations could be a recent colonization of urban areas by human means of synanthropic specimens from a single lineage of northeastern Argentina.","palabras_clave":"SCORIPION|HOLOKINETIC CHROMOSOMES|PARTHENOGENESIS|KARYOTYPE FISH NOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39262,"idioma_id":4,"titulo":"Productive and reproductive performance of first lactation purebred Holstein versus Swedish red & white X \u0001Holstein in central Argentina","resumen":"The  aim of this work was to compare productive and reproductive performance between pure Holstein (H)  and Swedish Red & White x Holstein crossbred (SRB\/H)  in first lactation dairy cows from the central region of Argentina. This  study included 450 lactations from a commercial dairy of central-southern Argentina. The  differences in  mean daily milk yield, days to first breeding  (DFB)  and number of  services  per  pregnancy  (NS\/P) between genotypes were evaluated. A  Cox  proportional hazard regression model was fitted to evaluate the breed effects on days open (DO)  and adjusting by  calving season and calving year. Days open were estimated trough survival curves for  H breed and SRB\/H  crossbred using Kaplan-Meier method.  Finally, average  lactation  curves  were  modeled  for   each genotype using a non-linear mixed model. Daily milk yield was not significantly different between genotypes. However, the cumulative 305-d yield and peak milk yield for  pure H was higher than for  SRB\/H.  Days to first breeding was lower for  SRB\/H  than pure H. The NS\/P  was higher for  pure H  than for  SRB\/H.  Regarding DO,  SRB\/H  breed had 1.00-1.71 higher likelihood to become pregnant than pure H. Days open of 50% of pure H was 30  d higher than for  SRB\/H.  The  results showed that SRB\/H crossbred were superior to pure H in  terms of  reproductive performance but inferior in  terms of  productive performance. Further studies may help to determine if  the economics of  dairying justifies the use of crossbreeding as  a herd fertility enhancing tool.","palabras_clave":"CROSSBREEDING|COX REGRESSION|DAYS OPEN|MILK YIELD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39263,"idioma_id":5,"titulo":"Salvar a la «generación perdida». Gubernamentalidad, empleabilidad y cultura del trabajo en un programa de empleo para jóvenes de Argentina","resumen":"En el marco de las políticas de empleo de la post-convertibilidad, bajo el paradigma de las denominadas ?políticas activas?, el Programa Jóvenes con Más y Mejor Trabajo, del Ministerio de Trabajo, Empleo y Seguridad Social de la Nación Argentina, aparece como un dispositivo de gran relevancia para pensar los actuales diagnósticos y prácticas de intervención sobre la problemática del empleo en jóvenes en torno a la ?cultura del trabajo?.  En la primera parte del texto analizaremos la lógica estatal de estas prácticas gubernamentales, o bien, la particular vinculación que proponen y producen entre los beneficiarios de estas políticas y el Estado. En la segunda parte identificaremos los elementos que constituyen la «empleabilidad» como objeto de intervención particular de esta política, definida en términos de ?hábitos?, ?competencias interaccionales? y de la instalación del ?esfuerzo? como valor .  El análisis está basado en un trabajo de campo llevado a cabo entre los años 2011 y 2012 en las Oficinas de Empleo de la Ciudad de Córdoba, Argentina, en el cual se entrevistó a distintos funcionarios del Ministerio y a agentes del equipo técnico de la Municipalidad, es decir, a los integrantes de la formación burocrática que pone en funcionamiento el Programa, con el objetivo de comprender los sentidos y las lógicas puestas en juego en la práctica y la gestión de esta política.","palabras_clave":"TRABAJO|EMPLEABILIDAD|JUVENTUD|GUBERNAMENTALIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39264,"idioma_id":5,"titulo":"?Clases sociales y prácticas laborales desde la perspectiva de las estrategias de reproducción social?","resumen":"En este trabajo  presentaremos los primeros resultados de una investigación en curso que se  propone analizar el espacio social de las clases y las estrategias de  reproducción social en el Gran Córdoba. Particularmente analizaremos las  distintas categorías de ?inactividad económica? como estrategias laborales  habilitadas por las diferentes posiciones sociales en este espacio y sus  posibilidades diferenciales de acumulación y reproducción.      La construcción del  espacio social a partir del volumen y estructura de los capitales, desde la  perspectiva de Pierre Bourdieu, supone la consideración de la trayectoria  histórica y la metodología del Análisis de Correspondencias Múltiples (ACM), que  permite ordenar el material empírico poniendo en juego las asociaciones y las  desigualdades trazadas por la distribución de los distintos tipos de recursos  considerados simultáneamente, evitando perder la complejidad de la trama  relacional estructural.       Para analizar las  estrategias laborales y comprenderlas en el marco de las estrategias de  reproducción social de las unidades domésticas (familias) utilizaremos datos  estadísticos de una fuente secundaria: la Encuesta Permanente de Hogares (EPH)  elaborada por el Instituto Nacional de Estadísticas y Censos (INDEC) de la  Argentina. Luego de presentar el ACM y el ordenamiento de los hogares en clases  estadísticamente construidas analizaremos el comportamiento de las variables  vinculadas al trabajo para cada clase o fracción de clase. De esta manera,  mostraremos cómo la inactividad puede ser comprendida en relación al peso  relativo del capital cultural, al capital económico y social, para cada sector  del espacio de las clases analizado.","palabras_clave":"TRABAJO|POBREZA|INACTIVIDAD|ESTRATEGIAS DE REPRODUCCION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39265,"idioma_id":4,"titulo":"Asymmetric capillary filling of non-Newtonian power law fluids","resumen":"A theoretical analysis of the capillary-drivenimbibitions of non-Newtonian fluids in conical capillariesis presented. More precisely, the consequences of thevariation in the fluid viscosity with the shear rate areinvestigated by using the inelastic power law model. Novelfluid dynamic behaviors are predicted, notably the asymmetryof filling times measured from different ends of theconical tube. The effect is due to the anisotropy of the flowdomain and takes place with simple Newtonian fluidsindeed. It is quantitatively described how shear-thinningfluids increase the asymmetry, and shear-thickening fluidsdecrease it. Relevant applications in microfluidic rheometryare envisaged. In addition, these results are of interest inactive fields of research such as passive micropumping andmicroflow rectification, where the geometric design ofmicrochannels is the key to control fluidic operations.","palabras_clave":"Capillary Filling|Conical Capillaries|Asymmetric filling|Microfluidic rheometry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39266,"idioma_id":4,"titulo":"Ecological drivers of guanaco recruitment: variable carrying capacity and density dependence","resumen":"Ungulates living in predator-free reserves offer the opportunity to study the influence of food limitation on population dynamics without the potentially confounding effects of top-down regulation or livestock competition. We assessed the influence of relative forage availability and population density on guanaco recruitment in two predator-free reserves in eastern Patagonia, with contrasting scenarios of population density. We also explored the relative contribution of the observed recruitment to population growth using a deterministic linear model to test the assumption that the studied populations were closed units. The observed densities increased twice as fast as our theoretical populations, indicating that marked immigration has taken place during the recovery phase experienced by both populations, thus we rejected the closed-population assumption. Regarding the factors driving variation in recruitment, in the low- to medium-density setting, we found a positive linear relationship between recruitment and surrogates of annual primary production, whereas no density dependence was detected. In contrast, in the high-density scenario, both annual primary production and population density showed marked effects, indicating a positive relationship between recruitment and per capita food availability above a food-limitation threshold. Our results support the idea that environmental carrying capacity fluctuates in response to climatic variation, and that these fluctuations have relevant consequences for herbivore dynamics, such as amplifying density dependence in drier years. We conclude that including the coupling between environmental variability in resources and density dependence is crucial to model ungulate population dynamics; to overlook temporal changes in carrying capacity may even mask density dependence as well as other important processes.","palabras_clave":"UNGULATES|HERBIVORE DYNAMICS|FOOD LIMITATION|ENVIRONMENTAL VARIATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39267,"idioma_id":4,"titulo":"On the ecology of the cursorial spider Odo bruchi (Araneae: Zoridae) in a grassland natural reserve from central Argentina","resumen":"The ?Ernesto Tornquist? Provincial Park (ETPP) is located inside the Ventania system (Argentina) and was created to protect one of the last relicts of pampean grassland. Spiders are used as ecological indicators to evaluate the nature conservation status. Moreover, when individual species are used, excellent basic information on their distribution and ecology is necessary for the choice of indicator taxa. Therefore, the goal of this study is to present the phenology and demography of the spider Odo bruchi Mello-Leitão 1938 (Zoridae), a cursorial spider present in the ETPP. Spiders were sampled bimonthly using pitfall traps between September 2009-2010 (first year), and March 2011-2012 (second year). Traps were arranged in line of 10 placed each 10m along a transect of 100m parallel to the longest axis of a grassland slope. We filled the traps with 1 500mL of ethylene glycol, and we examined each 60 day period and refilled. We collected 799 specimens in two years. Juveniles were the most abundant reaching 47.8% of the total, while males corresponded to 27.8% and females 24.4%. The results obtained in this study are important in order to generate basic knowledge for future studies on this spider species as a bio-indicator of the health of pampean grasslands.","palabras_clave":"ABUNDANCE|PHENOLOGY|DEMOGRAPHY|BIOINDICATOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39268,"idioma_id":4,"titulo":"Study of the stabilization process in Saccharomyces intra- and interspecific hybrids in fermentation conditions","resumen":"In this work, we evaluated the genetic stabilization of artificialintra- (Saccharomyces cerevisiae) and interspecific (S. cerevisiae x Saccharomyceskudriavzevii) hybrids under wine fermentative conditions. Large-scale transitions in genome sizeandgenome reorganizationswere observedduring this process. Interspecific hybrids seem to need fewer generations to reach genetic stability than intraspecific hybrids.The largest number of molecular patterns recovered among the derived cloneswas observed for intraspecific hybrids, particularly for those obtained by rare-mating.Molecular markers analyses revealed that unstable clones can suffer changes during the industrial process to obtain active dry yeast. When no changes in molecular markers and ploidy were observed after this process, no changes ingenetic composition were confirmed by comparative genome hybridization, considering the clone as a stable hybrid. According to our results, under these conditions, fermentation steps 3 and 5 (30-50 generations)suffice to obtain genetically stable interspecific and intraspecific hybrids, respectively.","palabras_clave":"SACCHAROMYCES CEREVISIAE|SACCHAROMYCES KUDRIAVZEVII|RARE-MATING|MOLECULAR MARKERS|DNA CONTENT|STABILIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39269,"idioma_id":4,"titulo":"Another migid in the wall: natural history of the endemic and rare spider Calathotarsus simoni (Mygalomorphae, Migidae) from a hill slope in central Argentina.","resumen":"A population of Calathotarsus simoni Schiapelli & Gerschman 1975 was discovered on a hillside in Ventania system, Buenos Aires, Argentina. Our objectives were to quantify burrow density, record physical burrow and door characteristics and describe the micro-habitat and spider diversity (through pitfall traps) associated with their environment. We counted 57 burrows in all plots and report burrow density of 0.01 burrows\/m2. Burrows were not distributed evenly, aggregation indices suggest that burrows are aggregated under some area plots, but are more evenly distributed on others. The trapdoor is relatively thick and rigid with beveled edges and the door is connected to the entrance rim by a narrow but firmly articulated hinge. Two egg sacs from females were obtained and data on eggs and spiderlings are presented. Spider diversity on the hillside shows the predominance of Linyphiidae, Nemesiidae, Gnaphosidae, Salticidae and Corinnidae. One juvenile of C. simoni was captured with pitfall traps.","palabras_clave":"TRAPDOOR SPIDER|BURROW DENSITY|AGGREGATION|VENTANIA SYSTEM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39270,"idioma_id":4,"titulo":"Neuropeptide Y regulates the leptin receptors in rat hypothalamic and pituitary explant cultures","resumen":"The aim of this work was to investigate whether the expression of leptin receptors (OBR) in the hypothalamic-pituitary (HP) axis is regulated by the orexigenic neuropeptide Y (NPY) during ovulation. To this end, we performed in vitro assays, using cultures of both hypothalamic and anterior pituitary explants from immature rats primed with gonadotropins to induce ovulation. In hypothalamic explants, protein expression of both the long and short OBR isoforms was increased by the presence of NPY at 100-500 ng\/ml and at 300-500 ng\/ml, respectively. Similarly, in pituitary explants, protein expression of the long isoform was increased between 30 and 300 ng\/ml while that of the short isoformwas increased only at 300 ng\/ml. When both tissues were incubated with NPY and BIBP3226, a specific antagonist of the NPY Y1 receptor subtype, the NPY-induced protein expression was totally reversed by the antagonist at almost every concentration assayed. However, this antagonist was not always capable of blocking the increase caused by the presence of NPY at transcript level. In conclusion, our results indicate that NPY is able to regulate the expression of both the long and the short isoforms of OBR in the HP axis, at least in part, through the NPY Y1 receptor. These results reinforce the fact that NPY and its NPY Y1 receptor play a critical role in reproduction by modulating leptin sensitivity.","palabras_clave":"NPY|LEPTIN RECEPTOR|HYPOTHALAMUS|PITUITARY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39271,"idioma_id":5,"titulo":"Caracterización de desechos de fundición arqueológicos: la metalurgia colonial en Fundiciones 2, Rinconada, Jujuy","resumen":"Fundiciones 2, Rinconada, Jujuy, instalación metalúrgica probablemente de finales del siglo XVIII, consta de dos recintos adosados, un refugio techado y cinco hornos de reverbero, tres de los cuales se encuentran dentro de un tercer recinto. Se presentan los resultados de los estudios microscópicos y de caracterización química de los desechos de fundición recuperados allí, para dar a conocer la naturaleza de la carga mineral y las condiciones de los procesos metalúrgicos desarrollados.  La metodología consistió en la observación y análisis mediante microscopio óptico, microscopio electrónico de barrido (MEB con espectrometría de energía dispersiva de rayos X EDRX) y microsonda analítica de electrones(MAE con espectrometría dispersiva de longitud de onda EDLO) de escorias metalúrgicas recuperadas en la excavación de dos hornos y dos recintos. Estos resultados, junto a la información contextual, permiten comprender el funcionamiento de esta instalación y aproximarnos a la tecnología de la metalurgia extractiva de minerales de  plomo y plata durante el período colonial en la región.","palabras_clave":"Arqueometalurgia|Puna de Jujuy|Escoria|Fundición"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39272,"idioma_id":4,"titulo":"Rolling Pampas agroecosystem: which landscape attributes are relevant for determining bird distributions","resumen":"Background: Agricultural intensification is among the main factors affecting biodiversity. The Rolling Pampas of Argentina have undergone through a process of landscape transformation and agricultural intensification that altered avian diversity patterns. Grassland area loss is argued to be the main reason for grassland bird species declines, but there is a lack of studies that compare cropland vs. pastures including other landscape features as determinants of species richness and distribution. Also, it is needed to understand how these relations are modified at different spatial scales. In this study, we explored how species are associated to different landscape attributes and elements like land use, roadside vegetation, trees, homesteads, and water bodies. Our aim was to explore how bird species are associated to the new elements of the Pampas agroecosystem at different spatial scales to reveal which are important for avian management.Results: We ran field surveys covering a range of land use and landscape complexity, defined by the variety of component features. We performed canonical correspondence and diversity partition analyses to determine the association of species with land use, landscape complexity, and particular anthropogenic elements. Our results show that land use type is an important driver of bird species distributions, but it is also controlled by the presence of trees, houses, and water bodies that provide nesting and food resources. Simple landscapes have higher species turnover rates (beta diversity) than complex ones with similar gamma diversity, demonstrating that the effect of landscape simplification on bird diversity differs across spatial scales, leading to different possible management and conservation strategies.Conclusions: New approaches are needed to manage agroecosystems for avian conservation. We need to take pragmatic approaches, and in highly disturbed ecosystems, anthropic elements have to be included as constituent parts of the system.","palabras_clave":"BIODIVERSITY|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39273,"idioma_id":4,"titulo":"Recreation potential assessment at large spatial scales: a method based in the ecosystem services approach and landscape metrics","resumen":"Ecosystem services (ES) is a useful framework for land-use decision making oriented to ensure human well-being. Outdoor recreation potential, as a cultural ecosystem service, pose particular challenges to its evaluation and mapping: it depends to a greater extent that other ES on stakeholders´ perception and values, it has lower generalization capacity, the delimitation of provisioning areas is not straightforward and it should be evaluated at different spatial scales. In this study, we propose a conceptual framework and method that is intended to cope with these challenges.Our method is based on landscape metrics measured at coarse scale, and campsite density as an indicator of ecosystem service supply and benefit capture. We applied this method to a case study in Argentina. We estimated outdoor recreation potential level using a quantile multiple regression analysis of the 0.9 quantile of campsite density with nine landscape metrics determinants of ecosystem service supply. We also explored two determinants of benefit capture with a linear stepwise regression analysis of differences between the predicted recreation potential and actual use. We stratified the analysis by ecoregion to distinguish the different weight of determinants of ecosystem service supply and benefit capture. The examined landscape determinants showed differences in their explicative capacity of outdoor recreation potential across ecoregions, showing that their generalization capacity is limited. For example, and contrary to our expectations, crop area did not have a negative effect for any of the 15 analyzed ecoregions. In fact, significant correlations are positive for three cases. Forest cover, on the other hand, had a positive effect only in the Pampas ecoregion, originally dominated by grasslands and where current forests consist in plantations of exotic trees. Results also showed that, in general, unrealized benefit increases with road and population density.Our method makes a contribution to the study of recreation potential under the framework of ES by taking into account important aspects that are sometimes overlooked. It considers the differences with other ecosystem services in terms of the underlying processes that control ecosystem service supply and benefit capture and it can be applied at a very wide spatial extent, at which approaches with other methods that are more information demanding is difficult. Yet complementary methods at more detailed spatial scales would provide additional information for a comprehensive estimation of outdoor recreation potential.","palabras_clave":"CULTURAL ECOSYSTEM SERVICES|MAPPING|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39274,"idioma_id":4,"titulo":"Concepts and methods for landscape multifunctionality and a unifying framework based on ecosystem services","resumen":"The potential of landscapes to supply multiple benefits to society beyond commodities production has received increasing research and policy attention. Linking the concept of multifunctionality with the ecosystem services (ES) approach offers a promising avenue for producing scientific evidence to inform landscape planning, e.g., about the relative utility of land-sharing and land-sparing. However, the value for decision-making of ES-based multifunctionality assessments has been constrained by a significant conceptual and methodological dispersion. To contribute towards a cohesive framework for landscape multifunctionality, we analyse case studies of joint ES supply regarding ten criteria designed to ultimately answer four aspects: (i) the multifunctionality of what (e.g., landscapes), (ii) the type of multifunctionality (e.g., based on ES synergies), (iii) the procedure of multifunctionality assessments, and (iv) the purpose of multifunctionality. We constructed a typology of methodological approaches based on scores for criteria describing the evaluation method and the level of stakeholder participation in assessments of joint ES supply. Surveyed studies and underlying types of methodological approaches (spatial, socio-spatial, functional, spatio-functional) differed in most criteria. We illustrate the influence of methodological divergence on planning recommendations by comparing two studies employing contrasting approaches (spatial and functional) to assess the joint supply of wildlife habitat and agricultural production in the Argentine Chaco. We distinguish between a pattern-based and process-based multifunctionality, where the latter can only be detected through approaches considering the ecological processes (e.g., ES complementarities) supporting the supply of multiple ES (functional and spatio-functional). Finally, we propose an integrated approach for assessing a socially-relevant process-based multifunctionality.","palabras_clave":"LANDSCAPE SERVICES|SPATIAL SCALES|ECOSYSTEM FUNCTIONS|STAKEHOLDER PARTICIPATION|LAND-SHARING|LAND-SPARING|LANDSCAPE PLANNING|SYNERGY|ECOSYSTEM SERVICE RELATIONSHIPS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39275,"idioma_id":4,"titulo":"JAW MUSCLE RECONSTRUCTION OF THE LATE PLIOCENE PSITTACIFORM NANDAYUS VOROHUENSIS FROM ARGENTINA","resumen":"The aim of this contribution is to verify the presence of the suborbital arch and the ethmomandibularis and pseudomasseter muscles in the holotype of Nandayus vorohuensis (Tonni and Noriega, 1996) in order to gain a better understanding of the capabilities of its cranio-mandibular complex and provide new tools for the discussion on the evolution of these unique structures. These apomorphies enables Psittaciformes to exert strong bite forces. Muscle reconstruction was performed based on the presence of muscle attachment scars and on the basis of the jaw-muscle descriptions of the extant Myiopsitta. Our results indicate that the suborbital arch is absent and the ethmomandibularis and the pseudomasseter muscles were present. This condition is shared with the extant Neotropical Pionites and Myiopsitta, so we assume that their trophic habits are similar. The heterogeneous distribution of these characters reaffirms the idea that the direction of the evolutionary changes may have varied independently in the crown group Psittaciformes more than once.","palabras_clave":"PSITTACIFORMES|ARINI|ETHMOMANDIBULARIS MUSCLE|PSEUDOMASSETER MUSCLE|SUBORBITAL ARCH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39276,"idioma_id":4,"titulo":"Age constraints on the dispersal of dinosaurs in the Late Triassic from magnetochronology of the Los Colorados Formation (Argentina)","resumen":"A measured magnetozone sequence defined by 24 sampling sites with normal polarity and 28 sites with reverse polarity characteristic magnetizations was established for the heretofore poorly age-constrained Los Colorados Formation and its dinosaur-bearing vertebrate fauna in the Ischigualasto?Villa Union continental rift basin of Argentina. The polarity pattern in this &#8764;600-m-thick redbed section can be correlated to Chrons E7r to E15n of the Newark astrochronological polarity time scale. This represents a time interval from 227 to 213 Ma, indicating that the Los Colorados Formation is predominantly Norian in age, ending more than 11 My before the onset of the Jurassic. The magnetochronology confirms that the underlying Ischigualasto Formation and its vertebrate assemblages including some of the earliest known dinosaurs are of Carnian age. The oldest dated occurrences of vertebrate assemblages with dinosaurs in North America (Chinle Formation)are younger (Norian), and thus the rise of dinosaurs was diachronous across the Americas. Paleogeography of the Ischigualasto and Los Colorados Formations indicates prolonged residence in the austral temperate humid belt where a provincial vertebrate fauna  with early dinosaurs may have incubated. Faunal dispersal across the Pangean supercontinent in the development of more cosmopolitan vertebrate assemblages later in the Norian may have been in response to reduced contrasts between climate zones and lowered barriers resulting from decreasing atmospheric pCO2 levels.","palabras_clave":"Dinosaurs|Late Triassic|Dispersal|Ischigualasto"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39277,"idioma_id":4,"titulo":"Influence of metallic oxides on ethanol oxidation","resumen":"An improvement in ethanol oxidation electrocatalysis is possible with multifunctional Pt-based combinations. Thus, the addition to Pt of Sn, Ir or Ni enhances the ethanol oxidation reaction (EO) and shifts the onset oxidation potential to lower values. It has been suggested that metallic oxides in the vicinity of Pt have the capacity of promoting the oxidation of residues coming from alcohol oxidative adsorption. In order to get a deeper knowledge on the ethanol oxidation catalysis, supported catalysts prepared either by thermal decomposition of polymeric precursors (PP) or by microwave assisted poliol reduction (MW) methodology are studied to determine the role of the catalyst components and its oxides on the improvement of ethanol oxidation. The catalysts are physically and electrochemically characterized. According to the synthesis method, the amount of SnO2 in the catalyst varies. Faceted particle structures for the microwave-synthesized catalysts are observed. By employing electrochemical techniques it is concluded that the catalyst with the highest amount of SnO2 has the best catalytic behaviour for EO.","palabras_clave":"SnO2|Ethanol oxidation|Microwave synthesis|Multicomponent catalysts"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39278,"idioma_id":4,"titulo":"Synthesis and characterization of a mixture of CoFe2O4 and MgFe2O4 from layered double hydroxides: band gap energy and magnetic responses","resumen":"Ab s t r ac tA mixture of nanocrystals of cobalt ferrite andmagnesium ferrite was obtained from Layered Double Hydroxides(LDH) through a co-precitationmethod with a theoretical molar ratio M2+:Fe3+ = 3:1,whereM2+ represents Mg2+ and\/or Co2+. The molar ratiosbetween Co2+:Fe3+ were 0.0 (0Co),0.2 (5Co), and 0.4(10Co). In order to assess the effect on the properties of the LDH and the ironoxides, the molar percentages were 0,5 and10%.Two different synthesis methods wereevaluated; (i) ageing at room temperature (rt), and (ii) hydrothermal ageing at200 °C in autoclave (ht), both methods needed 15h of ageing. Then, these LDH werecalcined in air atmosphere at 550 °C for10h.The calcined materials were characterizedby X-ray diffraction (XRD),thermogravymetric analysis (TGA),temperature-programmedreduction (TPR),infrared spectroscopy with Fourier transform (FTIR), Diffuse ReflectanceUV?visibleSpectroscopy (UV?vis-DRS), Mössbauer spectroscopyand inductively coupled plasma optical emission spectroscopy (ICP?OES). Themagneticresponse was analyzed using a vibrating sample magnetometer (VSM). The band gapenergy of their on oxides was determined through the UV?vis-DRS analysis. Throughthese studies it was possible to identify the presence of a mixture of cobalt ferriteand magnesium ferrite. Samples did not show hematite and cobalt oxides, but thepresence of MgO in the periclase phase was determined. This magnesium oxide promoteda good dispersion of the ferrites. Moreover, when a single ferrite phase of Co orMg was formed, a diminution of the crystal size with consequent enlarged valuesof band gap energy was observed. Thus, materials synthesized by room temperatureageing promoted the superparamagnetic behavior of samples, attributed to the contentof the cobalt ferrite structure in nanocrystals. In regard to the estimated bandgap energy, all samples exhibited low levels. These results indicate that thesesolids would be suitable for photocatalysts use in all visible light range, andthat they could be easily removed from the reaction medium by a simple magneticseparation procedure.","palabras_clave":"FERRITES|NANOCRYSTALS|BAND GAP ENERGY|MAGNETIC RESPONCES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39279,"idioma_id":4,"titulo":"Expeditious photochemical reaction towards the preparation of substituted chroman-4-ones.","resumen":"A facile photochemical preparation of 5-, 6-, and 7-substituted chroman-4-ones from aryl 3-methyl-  2-butenoate esters is described. The two-phase base-catalyzed method relies upon two consecutive  processes in one-pot reaction through a photo-Fries rearrangement and a based-catalyzed intramolecular  oxa-Michael addition to afford the desired products.","palabras_clave":"photochemistry|photosyntehsis|heterocycles|reaction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39280,"idioma_id":4,"titulo":"Diversity and Habitat Distribution of Birds in Coastal Marshes and Comparisons with Surrounding Upland Habitats in Southeastern South America","resumen":"We studied variation in bird assemblages with plant  associations for three different coastal marshes from  Southeastern South America (SESA) and assessed how marsh  bird assemblages related to nearby upland bird assemblages.We  surveyed bird species and plant structure along the tidal gradient  of each locality from the low tide level to the upper habitats  bordering coastalmarshes. Twenty species frequently used coastal  marshes, including relatively few migratory species.We found  that birds occurring in SESA coastal marshes do not have  distributions constrained to coastal marshes. Nonetheless, four  bird assemblages were recognized in association with vegetation  types and\/or sites. Among the recorded coastal marsh species, the  bay-capped wren-spinetail (Spartonoica maluroides) is both the  most frequent and the most habitat constrained. Bird richness  increases steadily along the tidal gradient associated with the  increase in vegetation structure, suggesting that bird richness is  directly explained by vegetation and indirectly by the physical  conditions influencing vegetation structure. Results highlight the  importance of SESA middle marshes as habitat for conservation  of some threatened SESA grassland birds.","palabras_clave":"Argentina|Bay-capped wren-spinetail|Bird diversity|Emberizid|Furnarid|Fresh marsh|grassland|South America"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39281,"idioma_id":4,"titulo":"Interfacial behaviour of diacylglycerol pyrophosphate and their mixtures with phosphatidic acid in response to pH and Zn2+","resumen":"Diacylglycerol pyrophosphate (DGPP) is a minor lipid that attenuates the phosphatidic acid (PA) signal, and also DGPP itself would be a signaling lipid. DGPP is an anionic phospholipid with a pyrophosphate group attached to diacylglycerol that was shown to respond to changes of pH, thus affecting the surface organization of DGPP and their interaction with PA. In this work, we have investigated how the presence of Zn2+, modulates the surface organization of DGPP and its interaction with PA at acid and basic pHs. Both lipids formed expanded monolayers at pH 5 and 8. At pH 5, monolayers formed by DGPP became stiffer when Zn2+was added to the subphase,&nbsp; while the surface potential decreased. At this pH, Zn2+ induced a phase transition from an expanded to a condensed phase state in monolayers formed by PA. Conversely, at pH 8 the effects induced by the presence of Zn2+ on the surface behaviors of the pure lipids were smaller. Thus, the interaction of the bivalent cation with both lipids was modulated by pH and by the ionization state of the polar head-groups. Mixed monolayers of PA and DGPP showed a non-ideal behavior and were not affected by the presence of Zn2+ at pH 8. This could be explained considering that when mixed, the lipids formed a close packed monolayer that could not be further modified by the cation. Our results indicate that DGPP and PA exhibit expanded and condensed phase states depending on pH, on the proportion of each lipid in the film and on the presence of Zn2+. This may have implications for a possible role of DGPP as a signaling lipid molecule.","palabras_clave":"diacylglycerol pyrophosphate|phosphatidic acid|plant lipid signaling|membrane packing"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39282,"idioma_id":4,"titulo":"Second species of Augochlorodes (Hymenoptera: Halictidae: Augochlorini) with known males and first record for the genus in Argentina","resumen":"The bee genus Augochlorodes Moure, up to now only known from Brazil, is recorded for the first time for Argentina. Augochlorodes politus Gonçalves &amp; Melo was found in the south of the province of Buenos Aires, mideastern Argentina, being the southernmost record for the genus. The female of A. politus is redescribed and the male described for the first time, being the second male known for this genus. The phylogenetic position of Augochlorodes among Augochlorini is briefly discussed.","palabras_clave":"PROVINCE OF BUENOS AIRES|SOUTH AMERICA|SWEAT BEES|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39283,"idioma_id":4,"titulo":"Use of multiple indicators to assess the environmental quality of urbanized aquatic surroundings in San Luis, Argentina","resumen":"Urbanization can cause significant changes in the integrity of fluvial ecosystems, which makes it necessary to assess environmental conditions of areas where population growth rates are high. A study of the environmental quality of Chorrillos River (San Luis-Argentina) and its tributaries was carried out in order to evaluate the potential effect of an urbanization gradient. Six sites were sampled along the main course and tributaries of the river. Urbanization variables were measured and included to calculate an Urbanization Index. Physical?chemical analyses were performed in water samples to evaluate water quality through the use of a simplified index of water quality (SIWQ). Plants, macroinvertebrates, and amphibians metrics were used to assess the biological state of the studied sites. The Urbanization Index varied significantly between sites and was significantly correlated to the SIWQ. However, no significant correlations were found between SIWQ and macroinvertebrates and amphibians variables. Water quality of Chorrillos River and its tributaries is good, but it is affected by anthropic influences as reflected by the declining of SIWQ values. Although biological sampling constitutes an important tool in the assessment of water quality of rivers, in this report biological results were not conclusive.","palabras_clave":"Urbanization|Environmental conditions |Water quality|Bioindicators"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39284,"idioma_id":4,"titulo":"Transgenerational effects of anadromy on juvenile growth traits in an introduced population of rainbow trout (Oncorhynchus mykiss)","resumen":"We determined whether the propensity for anadromy was related to maternal phenotype in a population of partiallyanadromous rainbow trout (Oncorhynchus mykiss). We identified the maternal phenotype (anadromous versus resident) of wildjuveniles from two successive cohorts using stable isotope analysis (15N) of muscle tissue and (or) strontium to calcium ratios inthe otolith core. We also tested the hypothesis that juvenile size and growth are related to maternal migratory history. For bothcohorts, juvenile size at capture and growth, as determined using otolith and scale structural analyses, were strongly related tomaternal migratory history. Offspring of anadromous mothers were larger and grew faster than resident offspring. Backcalculated length at age 1 of anadromous and resident adults provided support for a positive association between body size andanadromy, indicating that larger offspring are more prone to displaying anadromy. We conclude that maternal anadromy,which influences adult size and egg quality, affects the propensity of progeny to migrate, thus perpetuating the anadromoustactic across generations and influencing the establishment and persistence of anadromy","palabras_clave":"MATERNAL EFFECTS|ANADROMY|GROWTH|SALMONIDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39285,"idioma_id":4,"titulo":"Spatial Pattern and Habitat Requirements of Galaxias maculatus in the Last Un-Interrupted Large River of Patagonia: A Baseline for Management","resumen":"The relationship between the native Galaxias maculatus and environmental variables was studied in 52 siteslocated along 306 km of the main stemof the Santa Cruz River, the second largest river in Argentinean Patagonia.The abundance varied along the river, with three general sections clearly defined: upstream with minimumabundance increasing towards midstream and downstream areas. Distance to the sea and river wet width whichwere negatively significantly associated with abundance,and maximum depth explained the abundance in apolynomial shape ? achieving a total explanation of 41.1%. The best predictive model also combined the riversinuosity.Our results suggested that the construction of two proposed hydroelectric dams will modify thesevariables, which might generate changes in G. maculatus distribution. The information obtainedduring thepresent study represents valuable information for conservation management of this species.","palabras_clave":"habitat|Galaxiid,|large rivers|patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39287,"idioma_id":4,"titulo":"Ozone ProfilE Retrieval Algorithm (OPERA) for nadir-looking satellite instruments in the UV?VIS","resumen":"For the retrieval of the vertical distribution of ozone in the atmosphere the Ozone Pro&#64257;lE Retrieval Algorithm  (OPERA) has been further developed. The new version (1.26) of OPERA is capable of retrieving ozone pro&#64257;les from UV?VIS observations of most nadir-looking satellite instruments like GOME, SCIAMACHY, OMI and GOME-2. The setup of OPERA is described and results are presented for GOME and GOME-2 observations. The retrieved  ozone pro&#64257;les are globally compared to ozone sondes for the years 1997 and 2008. Relative differences between GOME\/GOME-2 and ozone sondes are within the limits as speci&#64257;ed by the user requirements from the Climate Change Initiative (CCI) programme of ESA (20 %in the troposphere, 15 % in the stratosphere). To demonstrate the performance of the algorithm under extreme circumstances, the 2009 Antarctic ozone hole season was investigated in more detail using GOME-2 ozone pro&#64257;les and lidar data, which showed an unusual persistence of the vortex over the Río Gallegos observing station (51 &#9702;S, 69.3W). By applying OPERA to multiple instruments, a time series of ozone pro&#64257;les from 1996 to 2013 from a single robust algorithm can be created","palabras_clave":"satellite|validation|ozone"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39288,"idioma_id":4,"titulo":"Song based species discrimination in a rapid Neotropical radiation of grassland seedeaters","resumen":"ver adjunto","palabras_clave":"Playback"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39290,"idioma_id":4,"titulo":"Comparative density functional theory based study of the reactivity of Cu, Ag and Au nanoparticles and of (111) surfaces towards CO oxidation and NO2 reduction","resumen":"      The reactivity of Cu, Ag and Au nanoparticles and of  the corresponding (111) surfaces of these elements towards CO oxidation and NO2  reduction has been investigated by means of DFT and DFT-D calculations. The  co-adsorption energies of CO and O on Ag and Au surfaces are smaller than that  corresponding to Cu surface but the oxidation reaction is much more energetically  favored for  the heavier metals. The adsorption energy of NO2, Eads,is  about 50% larger on nanoparticles than on the metal perfect surfaces, following  the almost general rule stating that the lower coordinated sites are those  where the interaction is the largest. Interestingly for the co-adsorption and  oxidation of CO an increase of reactivity is found for the Au nanoparticles  which is attributed to the large number of low coordinated sites due to the  specific shape of this nanoparticle induced by the adsorbates.  ","palabras_clave":"nanopartículas metálicas|oxidación- reducción|NO2 y CO|DFT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39291,"idioma_id":4,"titulo":"CO, CO2 and H2 adsorption on ZnO, CeO2 and ZnO\/CeO2 surfaces: DFT simulations","resumen":"The adsorption of the CO, CO2 and H2 molecules on several ceria and zinc oxidesurfaces was studied by means of periodical DFT calculations and compared withinfrared frequency data. The stable CeO2(111), CeO2(331) and ZnO(0001) perfectfaces were the first substrates considered. Afterwards, the surfaces with oxygenvacancies and a ZnO monolayer grown on Ceria (111) were also studied, to comparethe different surface behaviors and reactivity.The ceria surfaces are substantially more reactive than the ZnO surface in regards the CO2 molecule. The highest adsorption energy value for this molecule was found on the CeO2(111) surface with oxygen vacancy. Regarding the CO and H2 molecules, both have low or very low reactivity on all the studied surfaces, although some reactivity was found for the case of CO adsorbed onto the surfaces with oxygen vacancies, whereas H2 exhibited reactivity in the&nbsp; CeO2(111) surface with oxygen vacancy. This effort aims to contributing to build firm foundations for novel process developments in the methanol synthesis from carbon oxides, the steam reforming of methanol for hydrogen production and\/or the water-gas shift reaction.&nbsp;","palabras_clave":"Metanol|adsorción|óxidos mixtos|DFT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39292,"idioma_id":4,"titulo":"Development of novel alginate lyase cross-linked aggregates for the oral treatment of cystic fibrosis","resumen":"Alginate lyase (AL) from Sphingobacterium multivorum is unsuitable for oral delivery because of its rapidinactivation under acidic conditions. The synthesis of a novel crosslinking enzyme aggregate (CLEA) ofAL (AL-CLEA) is proposed. AL precipitation with 95% ammonium sulfate and combined with lowmethoxylated pectin (LMP), showed 100% precipitation yield. Crosslinking with glutaraldehyde reducedthe AL-CLEA activity to less than 1%, but addition of bovine serum albumin (BSA) and LMP duringAL-CLEA synthesis increased the activity yield to 14.7%. AL-CLEA exposed to simulated gastric conditions(pH 1.2 to 3.0) showed more than 70% retention of enzymatic activity. Moreover, AL-CLEA showedthermal stability at temperatures over 37 C. Stability against chemical denaturants (ethanol, acetone andpropylene glycol) showed that AL-CLEA was 14 times more stable than free AL in all cases. Finally, a 25%viscosity reduction of alginate solution was achieved with AL-CLEA. This is the first report of AL-CLEAsynthesis and evaluation.","palabras_clave":"alginate lyase|CLEAs|Cystic Fibrosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39293,"idioma_id":4,"titulo":"Childhood sexual experiences with an older partner among men who have sex with men in Buenos Aires, Argentina.","resumen":"This study sought to describe childhood sexual experiences with older partners (CSEOP) amongmenwho have sex withmen(MSM)in Buenos Aires, Argentina.MSMwere recruited through respondent driven sampling. They responded to a computer administered self- interview with questions on CSEOP, operationalized as manual, oral, genital, or anal contact prior to age 13 with a partner at least 4 years older. Of the 500 respondents, only 25% identified as gay. Eighteen percent of the respondents reported CSEOP, the majority of whom did not feel they were hurt by the experience and did not consider it to be childhood sexual abuse (CSA). Over two-thirds of MSM who reported CSEOP said that their older partner was a female. Only 4% of those with a female partner felt their experience was CSA compared to 44% of those who had a male partner. Among all men reporting CSEOP, those who felt sexually abused were more likely to have been physically forced or threatened, physically hurt, and emotionally hurt than those who did not feel sexually abused. Having CSEOP, being hurt by the experiences, and perceiving the experiences as sexual abuse were not associated with current HIV sexual risk or substance use behavior. In this sample ofMSM in Argentina, a substantial minority reported CSEOP. Those who felt they had been sexually abused were much more likely to have had an older male partner than an older female partner, and were more likely to report having been physically forced and threatened by their older partner. ","palabras_clave":"MSM|Sexual experience|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39294,"idioma_id":4,"titulo":"HIV testing practices among men who have sex with men in Buenos Aires, Argentina","resumen":"The objective of the study was to explore HIV-testing practices among men who have sex with men (MSM) in Buenos Aires, Argentina, in light of current international health guidelines that recommend frequent HIV testing for MSM who engage in high-risk behavior. Participants, who were recruited using respondent-driven sampling (RDS), were 500 mostly young, nongay-identified MSM of low socioeconomic status, high levels of unemployment, living mainly in the less-affluent areas surrounding Buenos Aires, and lacking health insurance. They provided blood samples for HIV testing and responded to a Computer Assisted Self Interview. Fifty-two percent had never been tested for HIV, and 20% had been tested only once; 17% were found to be HIV infected, of whom almost half were unaware of their status. Main reasons for never having tested previously were: not feeling at risk, fear of finding out results, and not knowing where to get tested. Among those previously tested, men had been tested a median of 2 times with their most recent test having occurred a median of 2.7 years prior to study enrollment. Of those who had not tested positive before entering the study, only 41% returned for their results. HIV testing was infrequent and insufficient for early detection of infection, entry into treatment, and protection of sexual partners. This was particularly the case among nongay-identified MSM. Testing campaigns should aim to help MSM become aware of their risk behavior, decrease fear of testing by explaining available treatment resources and decreasing the stigma associated with HIV, and by publicizing information about free and confidential testing locations. Rapid HIV testing should be made available to eliminate the need for a return visit and make results immediately available to individuals who are tested.","palabras_clave":"HIV TESTING|MSM|BUENOS AIRES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39295,"idioma_id":4,"titulo":"HIV, HBV and HCV molecular epidemiology among trans (transvestites, transsexuals and transgender) sex workers in Argentina","resumen":"Commercial sex work is frequent among male-to-female transvestites, transsexuals and transgenders in Argentina, leading to high susceptibility to HIV, HBV, and HCV among other sexually transmitted infections. In a global context of scarce data on the trans sex workers population, this study was aimed to study the genomic characterization of these viruses. Plasma presence of HIV, HBV, and HCV genomic material was evaluated in samples from 273 trans sex workers. Genomic sequences of HIV-gag, pol, and vif-vpu genes, HBV-S gene, and HCV-5&#8242;UT and NS5B genes were obtained. Molecular characterization involved phylogenetic analysis and several in silico tools. Resistance-associated mutations in HIV and HBV pol genes were also analyzed. The HIV genomic characterization in 62 trans sex workers samples showed that 54.8% of the isolates corresponded to BF intersubtype recombinants, and 38.7% to subtype B. The remaining were classified as subtypes C (4.8%) and A (1.6%). HBV and HCV co-infection prevalence among HIV positive trans sex workers yielded rates of 3.2% and 6.5% respectively. Drug resistance-associated mutations were found in 12\/62 (19%) HIV pol sequences, but none among HBV. Based on phylogenetic relationships, HIV isolates characterized as subtypes BF and B appeared intermingled with those from other high-risk groups. Despite trans sex workers declared not to have received antiviral treatment, complex drug resistance-associated mutation patterns were found in several HIV isolates. Planned prevention, screening, and treatment are needed to reduce further transmission and morbidity","palabras_clave":"HIV|Trans sex workers|Viral hepatitis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39296,"idioma_id":4,"titulo":"Synthesis of biodiesel from soybean oil using zinc layered hydroxide salts as heterogeneous catalysts","resumen":"                                                In this work, the transesterification of soybean oil with methanol using layered heterogeneous catalysts to produce biodiesel was studied. The zinc hydroxy acetate salt Zn5(OH)8(CH3COO)2.4H2O (abbreviated Zn-Ac) and zinc hydroxy nitrate Zn5(OH)8(NO3)2.2H2O (abbreviated Zn-Nit), which have a layered structure, were synthesized (chemical precipitation) and characterized by X-ray diffraction, infrared spectroscopy, scanning electron microscopy, particle size distribution measurements, specific surface area determination and thermogravimetric analysis. Zn-Ac and Zn-Nit were tested in the transesterification of soybean oil at 100 °C for 2 h. Zn-Nit presented 83.9% oil conversion with 51.5% FAME yield, and it was stable in three consecutive tests, also showing good tolerance to aqueous content. Zn-Ac was not stable. The salts transformed into Zn glycerolate at 140 °C in the reaction medium. ","palabras_clave":"Heterogeneous Basic Catalyst|Zinc Hydroxy Acetate |Zinc Hydroxy Nitrate |Transesterification|Soybean oil"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39297,"idioma_id":4,"titulo":"Triacylglycerol accumulation and oxidative stress in Rhodococcus species: differential effects of pro-oxidants on lipid metabolism","resumen":"In general, members of Rhodococcus genus are highly resistant to   desiccation. Desiccation is a complex process which includes the   formation of reactive oxygen species that results in significant damage   to cells. In this study, we demonstrate that extremophile   actinobacterial strains isolated from diverse environments, mainly   belonging to Rhodococcus genus, exhibited high tolerance to the   pro-oxidants hydrogen peroxide (H2O2) and methyl   viologen (MV). In addition, we investigated the possible   interconnections between the responses of the oleaginous Rhodococcus   opacus PD630 to oxidative stress and lipid metabolism, since both   processes demand a metabolic reorganization of cells. Experiments with   metabolic inhibitors showed differential effects of both pro-oxidants on   lipid metabolism in PD630 cells. The inhibition of carotenoid   biosynthesis by the addition of diphenylamine to the media negatively   affected the tolerance of cells to H2O2, but not   to MV. The inhibition of triacylglycerol (TAG) biosynthesis and   accumulation in PD630 did not affect the tolerance of cells to H2O2 and MV; whereas, the blockage of lipolysis decreased the tolerance of cells to H2O2 (but not MV) under carbon-starvation conditions. Interestingly, the addition of MV to the media (but not H2O2)   induced a reduction of TAG accumulation by cells. Resuming, results of   this study revealed metabolic connections between lipid metabolism and   oxidative stress responses in R. opacus PD630, and probably in other   extremophile TAG-accumulating rhodococci.","palabras_clave":"STRESS|RHODOCOCCUS|LIPIDS|METABOLISM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39298,"idioma_id":4,"titulo":"Measurements of Fusion Cross Sections in the Systems 10,14,15C + 12C with a Multi-sampling Ionization Chamber","resumen":"      The interaction between neutron-rich nuclei plays an important role for  understanding the reaction mechanism of the fusion process as well as for the  energy production through pycnonuclear reactions in the crust of neutron stars.  We have performed the first measurements of the total fusion cross sections in  the systems 10,14,15C + 12C using a new active target-detector system. In the  energy region accessible with existing radioactive beams a good agreement  between the experimental and theoretical cross sections is observed. This gives  confidence in our ability to calculate fusion cross sections for systems which  are outside the range of today?s radioactive beam facilities.  ","palabras_clave":"Fusion reactions|Exotic nuclei"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39299,"idioma_id":4,"titulo":"Distinctive intrahepatic characteristics of pediatric and adult pathogenesis of chronic hepatitis C infection","resumen":"Mechanisms leading to liver damage in chronic hepatitis C (CHC) are being discussed, but both the immune system and the virus are involved. The aim of this study was to evaluate intrahepatic viral infection, apoptosis and portal and periportal\/interface infiltrate in paediatric and adult patients to elucidate the pathogenesis of chronic hepatitis C. HCV-infected, activated caspase-3(+) and TUNEL(+) hepatocytes, as well as total, CD4(+), CD8(+), Foxp3(+) and CD20(+) lymphocytes infiltrating portal and periportal\/interface tracts were evaluated in 27 paediatric and 32 adult liver samples by immunohistochemistry or immunofluorescence. The number of infected hepatocytes was higher in paediatric than in adult samples (p 0.0078). In children, they correlated with apoptotic hepatocytes (activated caspase-3(+) r = 0.74, p < 0.0001; TUNEL(+) r = 0.606, p 0.0017). Also, infected (p = 0.026) and apoptotic hepatocytes (p = 0.03) were associated with the severity of fibrosis. In adults, activated caspase-3(+) cell count was increased in severe hepatitis (p = 0.009). Total, CD4(+), CD8(+) and Foxp3(+) lymphocyte count was higher in adult samples (p < 0.05). Paediatric CD8(+) cells correlated with infected (r = 0.495, p 0.04) and TUNEL(+) hepatocytes (r = 0.474, p = 0.047), while adult ones correlated with activated caspase-3(+) hepatocytes (r = 0.387, p 0.04). In adults, CD8(+) was associated with hepatitis severity (p < 0.0001) and correlated with inflammatory activity (CD8(+) r = 0.639, p 0.0003). HCV, apoptosis and immune response proved to be involved in CHC pathogenesis of both paediatric and adult patients. However, liver injury in paediatric CHC would be largely associated with a viral cytopathic effect mediated by apoptosis, while in adults it would be mainly associated with an exacerbated immune response.","palabras_clave":"APOPTOSIS|HEPATITIS C VIRUS|INFECTED HEPATOCYTES|INFILTRATED MICROENVIRONMENT|PATHOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39300,"idioma_id":5,"titulo":"Semiótica de la imagen en Arqueología: el caso de los 'escutiformes'","resumen":"En sociedades carentes de escritura o de otro soporte material del texto lingüístico, la imagen es, frecuentemente, uno de los respaldos discursivos más corrientes de la ideología de grupo. La imagen, tal como aparece en el arte rupestre, en la cerámica o en la textilería arqueológicas, tiene mucho para decir sobre cómo se pensaron a sí mismas y cómo pensaron el mundo culturas hoy desaparecidas; así también, sobre cómo se dieron en ellas las disputas por el poder que es, siguiendo a Anthony Giddens, uno de los tres aspectos de la interacción social y al que el sociólogo británico entiende como 'la aptitud de producir una diferencia en un estado de cosas o curso de sucesos preexistentes' (2011:23). Para el estudio de la imagen -en nuestro caso, la imagen arqueológica-, creemos que la semiótica peirceana es una herramienta sumamente útil, capaz de abrirnos camino a hipótesis interpretativas eficaces y bien sustentadas. De acuerdo a estos lineamientos, presentamos el análisis semiótico de las representaciones de hachas personificadas, conocidas como 'escutiformes', cuya presencia en el arte rupestre tardío del Noroeste argentino (s. X ? XV), se ha asociado siempre a la idea de surgimiento y consolidación de individuos o élites de poder que pugnan por el control de determinados territorios y recursos, en un contexto de conflicto endémico que, en este lapso, afectó a gran parte de la comunidades andinas centromeridionales.","palabras_clave":"ESCUTIFORMES|SEMIOTICA|IMAGEN|PODER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39301,"idioma_id":4,"titulo":"Osmotic adjustment and maintenance of the redox balance in root tissue may be key points to overcome a mild water deficit during the early growth of wheat","resumen":"In this investigation we analyzed in detail the consequences of water deficit during the first four days of wheat development, focusing on root growth as affected by eventual changes in cell cycle regulation and oxidative processes. Root elongation decreased under water restriction in correlation with the intensity of this limitation, but the total number of cells between the quiescent center and the start of the rapid elongation zone in the root apex did not vary. Neither lipid peroxidation nor protein carbonylation increased in the roots of water-starved seedlings (&#968;w: -0.6 MPa); accordingly, catalase activity increased, and transcript levels of cat2 gene were enhanced. Superoxide dismutase activity rose at day 2 and 3 and, unlike catalase, displayed quite similar levels on comparing roots and coleoptiles. Proline and total soluble carbohydrates increased in the roots of water-starved seedling. Total conductivity and osmolality were also augmented. No changes in the transcript levels of the markers related to G1-S transition phase of cell cycle could be detected. However, two expansin genes (TaEXPB8 and TaEXPA5) were up-regulated in roots under water deficit. We conclude that wheat root elongation in water-deprived seedlings was simply hampered by lack of water income to cells. The enhanced expression of two root expansin genes is probably related to the eventual need of a quick cell wall expansion to allow the existing root cells to recover normal turgor, in case of sudden rewatering.","palabras_clave":"Root growth|Triticum aestivum|Water deficit|Root apical meristem|Oxidative stress|Osmolyte accumulation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39302,"idioma_id":4,"titulo":"Synthesis of N-aryl imidazoles catalyzed by copper nanoparticles on nanosized silica coated maghemite","resumen":"A magnetically recoverable","palabras_clave":"COPPER NANOPARTICLES|MAGNETIC CATALYST|MAGHEMITE|C-N CROSS-COUPLING|N-ARYLATION|IMIDAZOLE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39303,"idioma_id":4,"titulo":"Biomarker responses in caged carp (Cyprinus carpio) and native collected fish (Leporinus obtusidens) in the río de la plata estuary, Argentina","resumen":"Punta Lara is located in the Río de la Plata estuary near industrial   areas contaminated mainly by organic pollutants. In this work, the   responses and status of hepatic biomarkers were studied in juvenile carp   (Cyprinus carpio) by means of a 21-day field exposure in cages and collection of juvenile native fish (Leporinus obtusidens)   at Punta Lara. The analyzed hepatic biomarkers were: enzymatic activity   of glutathione-S-transferase (GST), catalase (CAT) and superoxide   dismutase (SOD), lipid peroxidation level using the thiobarbituric acid   reaction (TBARS), and CYP1A protein expression, condition factor (CF)   and liver somatic (LSI) index. Taking into account oxidative stress   responses, SOD activity was increased in both species, while CAT was   increased in C. carpio and decreased in L. obtusidens; TBARS levels indicated that oxidative damage was possibly exerted only in L. obtusidens.   Biotransformation responses mediated by CYP1A were observed in both   species, while GST activity was induced mainly in carps. Considering   morphometric indices, CF and LSI were significantly increased in carps   while CF decreased in native species. The anthropogenic pollution   detected in this study in Punta Lara was associated with differences in   biomarkers on both fish species, although a different pattern of   response was observed.     Environ. Toxicol.. doi:&nbsp;10.1002\/tox.21823","palabras_clave":"biomarkers|Cyprinus carpio|field\/cage assay|persistent pollutants"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39304,"idioma_id":4,"titulo":"Search for endophytic diazotrophs in barley seeds","resumen":"Eight endophytic isolates assigned to Pseudomonas, Azospirillum, and Bacillus genera according to pheno-genotypic features were retrieved from barley seeds under selective pressure for nitrogen-fixers. Genetic relationships among related isolates were investigated through RAPD. Six isolates displayed nitrogen-fixing ability, while all could biosynthesize indolacetic acid in vitro and showed no antibiosis effects against Azospirillum brasilense Az39, a recognized PGPR.","palabras_clave":"AZOSPIRILLUM|BACILLUS|PSEUDOMONAS|PGPR|RAPD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39305,"idioma_id":4,"titulo":"Neuroimmune aspects of Sjögren's Syndrome: Role of VIP\/VPAC system in immune and salivary gland epithelial cell function","resumen":"Sjögren syndrome (SS) is a chronic inflammatory disease characterized by salivary and lacrimal gland dysfunction although extraglandular manifestations are also found. Suitable study models and in vitro cell culture designs are used to approach SS pathogenic mechanisms. Cellular and molecular pathways involved in gland homeostasis loss and the autoimmune response are focused in the search of novel drug targets and biomarkers. Vasoactive intestinal peptide (VIP) has trophic, pro-secretory and immunomodulatory effects in several chronic and autoimmune disease models. Here we review evidence pointing to its role as an endogenous modulator of gland homeostasis at early stages of the disease. Particularly, mechanisms involving VIP\/VPAC system in the course of salivary function impairment in the non obese diabetic (NOD) mouse model of Sjögren?s syndrome are described.","palabras_clave":"VIP|síndrome de Sjogren|glandulas exocrinas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39306,"idioma_id":4,"titulo":"Nutritional and Functional Properties of Aqueous and Hydroalcoholic Extracts from Argentinean Propolis","resumen":"Bee propolis is a natural product extensively used as an ingredient in functional foods in amounts that may confer health benefits. The aim of this study was to investigate the nutritional and functional properties (antioxidant activity) of aqueous and ethanolic extracts of propolis samples from Santiago del Estero province, northern Argentina. All propolis extracts contained macronutrients (glucose, fructose, sucrose and proteins), micronutrients (Na, K, Ca, P and Mg) and trace elements (Fe). Spectrophotometric, TLC and HPLC-DAD analyses showed the presence of several phenolic, flavonoid and non-flavonoid compounds, but in all cases the flavonoids prevailed. The PCA of polyphenolic content provided a clear separation of propolis in Group 1 (SE1, 2, 3, 4 and 7) and Group 2 (SE5 and 6) associated with phenolic compound content and collection regions. Two compounds, pinocembrin and chrysin, which could be used  as chemical markers of Santiago del Estero propolis, were identified in all samples. Propolis samples extracted with water presented better radical scavenging ability than ethanolic extracts, independent of the antioxidant method (scavenging activity of ABTS&#61623;+, DPPH&#61623;, HO&#9679; and O2  &#9679;- and &#946;-carotene bleaching test). Such results correlated closely with the levels of total phenols and flavonoids in samples. The results justify the use of Argentine propolis as a functional dietary supplement.","palabras_clave":"Argentine propolis| Micronutrients|Macronutrients|Functional compounds"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39307,"idioma_id":4,"titulo":"A serendipitous conversion in one step of 3H-1,2-dithiole-3-thione to (E)-3-[1-(alkylthio)alkylidene]-3H-1,2-dithiole: an experimental and theoretical study","resumen":"In the course of our studies on 3H-1,2-dithiole-3-thione synthesis, a serendipitous reactivity with á-haloketones, in the presence of excess of potassium iodide, has been observed. Instead of the expected reaction of the nucleophile in a remote point of the molecule, we have obtained a product resulted from the electrophile character of the thiocarbonyl moiety on the 3-position of the 1,2-dithiole. In order to obtain an efficient protocol in terms of energy efficiency, this methodology was studied under conventional and microwave heating with similar or better results in the latter conditions. Simplicity and great efficiency in this one-step transformation are some of the advantages of this reaction. Moreover, the results can be explained according to the Pearson?s hard and soft acid base theory.","palabras_clave":"3H-1,2-Dithiole-3-thione|(E)-3-Alkylidene-3H-1,2-dithiole|DFT calculations|HSAB theory"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39308,"idioma_id":4,"titulo":"Abundance of native fishes, wild introduced salmonids, and escaped farmed rainbow trout in a Patagonian reservoir","resumen":"The introduction of salmonids in Patagonia has resulted in significant impacts on its lakes, as well as a major impact on streams, in which native fishes seem to have been displaced almost completely by rainbow trout (Oncorhynchus mykiss). Another perspective is that the introduced salmonid species have resulted in wild fish populations that sustain an eco- nomically important sport fishery. The wide distribution and high abundance of escaped farmed rainbow trout, and a clear decrease in the abundance of native and successfully introduced salmonid species in Alicura Reservoir were all observed, based on comparison of recent data and data from 1993 to 1995 corresponding to littoral gillnet captures. Thus, both native fish and introduced salmonid populations seem to have been drastically reduced in the presence of farmed fish escapees. The results of the present study regarding fish escapes deserve major consideration when making deci- sions about fish cage culture activities for other Patagonian reservoirs.","palabras_clave":"CAGE CULTURE|FISH ESCAPES|NATIVE FISHES|PATAGONIA|RAINBOW TROUT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39309,"idioma_id":4,"titulo":"Identif ication and molecular characterization of a phytoplasma associated with sunflower in Argentina","resumen":"Sunflower (Helianthus annuus L.) plants showing capitulum with virescence, phyllody and flower malformation, shortened internodes and abnormal branches were found in a field in Pedro Luro (Buenos Aires province, Argentina). Pleomorphic bodies resembling phytoplasmas were observed in sieve tube elements of symptomatic plants but not in healthy ones. DNA from all symptomatic sunflower plants analysed yielded, in direct PCR with phytoplasma universal primers P1\/P7 and R16F2n\/R2, fragments of expected size 1.8&nbsp;kb and 1.2&nbsp;kb, respectively. The phytoplasma associated with the disease, was named Sunflower Phyllody (SunPhy). Real and putative RFLP of the 16S rDNA showed the affiliation of SunPhy to 16SrIII (X-disease group), subgroup J. The 16S rDNA sequence from SunPhy showed the highest identity (99&nbsp;%) with 16SrIII members and the phylogenetic tree confirmed a closer relationship to subgroup J of the 16SIII ribosomal group. This is the first report of a phytoplasma related to the 16SrIII group affecting sunflower.","palabras_clave":"PHYTOPLASMA|X-DISEASE|SUNFLOWER|16SrDNA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39310,"idioma_id":5,"titulo":"Metáforas de la desigualdad social. Una lectura de El hombre de al lado","resumen":"El artículo aborda los fundamentos simbólicos del regímen de desigualdades sociales en la Argentina contemporánea a partir del análisis de las metáforas visuales presentes en el film El hombre de al lado (Cohn y Duprat, 2009).&nbsp;","palabras_clave":"CINE ARGENTINO|DESIGUALDAD SOCIAL|METAFORA|IMAGINARIOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39311,"idioma_id":4,"titulo":"Palladium nanoparticle?s surface structure and morphology effect on the catalytic activity for dry reforming of methane","resumen":"Low loaded Pd\/-Al2O3catalysts (<0.5 wt% Pd) were characterized and tested for CH4reforming withCO2at 650&#9702;C. The catalysts were prepared by a recharging procedure, using an organometallic precursor,followed by intermediate washing and calcination steps. FTIR spectra of adsorbed CO showed that thePd surface structure and the particle size were dependent on the number of post-impregnation washingsteps. A catalyst sample with a metal dispersion of 33% showing well defined low-index planes (by FTIR)and nearly spherical particles (by TEM) was obtained using two-washing steps. In the reaction, it exhibiteda high initial activity followed by a pronounced deactivation due to carbon nanofiber?s formation andsintering. TEM analysis of the used catalyst revealed the presence of spherical Pd particles at the end ofthe fibers that were not attached to the support surface. On the other hand, a high dispersion sample (78%)with a large fraction of Pd atoms with low coordination was obtained by applying three washing stepsafter impregnation. The presence of small hemispherical particles and larger nearly-flat ones attachedto the support were found by TEM. In this case, the catalyst initially showed a very low activity thatincreased slowly up to a steady value. Although sintering also occurred and the surface structure ofthe used catalyst resembled the one of the low dispersion catalyst, the amount of carbon formed wasquite low. The observed activation under reaction conditions was associated with the slow developmentof a surface structure that exhibited mainly the (1 0 0) plane favoring methane dissociation. However,the initial interaction of the particles with the support suggested by TEM micrographs seems to remainunaltered despite the particle size increase. Consequently, the process of nanofiber formation and particleseparation was inhibited.","palabras_clave":"Pd (palladium)|Catalyst preparation|Dry reforming|Particles morphologyCarbon"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39312,"idioma_id":4,"titulo":"Dynamic laser speckle and fuzzy mathematical morphology applied to studies of chemotaxis towards hydrocarbons","resumen":"The movement of the microorganisms towards a higher concentration of the chemical attractant is called positive chemotaxis and is involved in the efficiency of chemical degradation. Several studies are focused in this field related to genomics, and towards demonstrating chemotactic responses by bacteria, but there is little information related to the activity and morphology of their response. In this work, we use a recently reported dynamic speckle laser method, to process images and to distinguish motile surface patterns per area of colonisation by applying image processing techniques called fuzzy mathematical morphology (FMM). The images of bacterial colonies are usually surfaced, with vague edges and non-homogeneous grey levels. Hence, conventional image processing methods for shape analysis cannot be applied in these cases. In this paper, we propose the application FMM to solve this problem. The approach given was effective to segment,detect and also to describe colonisation patterns.","palabras_clave":"DYNAMIC LASER SPECKLE|FUZZY MATHEMATICAL MORPHOLOGY|BIODEGRADATION|CHEMOTAXIS|HYDROCARBONS|PSEUDOMONAS|SWIM ASSAY|ENVIRONMENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39313,"idioma_id":4,"titulo":"The Effect of Zuccagnia punctata, an Argentine Medicinal Plant, on Virulence Factors from Candida Species","resumen":"Zuccagnia punctata Cav. has been used as a traditional medicine in Argentina for the treatment of bacterial and fungal infections. In this study, we evaluated the ability of Z. punctata extract (ZpE) and compounds isolated from it to inhibit the growth and virulence factors of Candida species. ZpE showed inhibitory activity against planktonic cells of all assayed Candida species with MIC values of 400 &#956;g\/mL and with MFC values between 400 and 1,200 &#956;g\/mL. The principal identified compounds by HPLC-MS\/MS and UV-VIS were chalcones (2&#697;,4&#697;-dihydroxy-3&#697;-methoxychalcone, 2&#697;,4&#697;- dihydroxychalcone), flavones (galangin, 3,7-dihydroxyflavone and chrysin) and flavanones (naringenin, 7-hydroxyflavanone and pinocembrine). These compounds were more effective as inhibitors than the extracts upon biofilm formation as well as on preformed Candida biofilm and yeast germ tube formation. Furthermore, ZpE and chalcones are able to inhibit exoenzymes, which are responsible for the invasion mechanisms of the pathogens. All these effects could moderate colonization, thereby suppressing the pathogen invasive potential. Our results indicate that ZpE and chalcones could be used in antifungal therapy.","palabras_clave":"Candida|Virulence factors |Chalcones|Zuccagnia punctata"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39314,"idioma_id":4,"titulo":"Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits","resumen":"The present study evaluatedthe plasma fatty acidlevels and thevascular prostaglandin releaseina rabbit model of early hypercholesterolemia with endothelial dysfunction. Rabbits were fed either a control diet (CD) or a diet containing 1 % cholesterol (HD) for 5-6 weeks. The level of fatty acids was measured in plasma. The levels of prostaglandin and nitric oxide (NO) released from aorta were also determined. Vascular morphology of aorta was characterized by intima and media thickness measurement. The rabbits fed with HD had higher levels of arachidonic acid (ARA) and lower levels of oleic acid (OLA). Linoleic acid (LNA) level was unchanged.  PGI2 and NO were diminished and PGF2&#945;levels, the PGI2\/TXA2 ratio and the intima\/media ratio were increased in rabbits fed with HD. In conclusion, feeding a HD for a short period increased ARA plasma levels and unbalanced release of vasodilator\/vasoconstrictor PG redirecting the pathway to vasoconstrictor metabolite release. These lipid metabolism alterations in addition to the reduced NO levels and the moderate changes in the vascular morphology would contribute to the endothelial dysfunction in this animal model. Therefore, the present findings support the importance ofearly correction or prevention of high cholesterol levels to disruptthe endothelial dysfunction processthat leadsto cardiovascular disease.","palabras_clave":"HIPERCHOLESTEROLEMIA|PROSTAGLANDINS|ENDOTHELIAL DISFUNCTION|FATTY ACIDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39315,"idioma_id":4,"titulo":"CIRCULATING GONADAL AND ADRENAL STEROIDS IN AMYOTROPHIC LATERAL SCLEROSIS: POSSIBLE MARKERS OF SUSCEPTIBILITY AND OUTCOME","resumen":"Changes of some circulating steroids have been reported in patients with sporadicamyotrophic lateral sclerosis (ALS), but a full comparison of the adrenal and gonadalsteroid profile between ALS patients and controls has not be performed. Considering thatrespiratory failure is one frequent cause of death in ALS, we searched, as well, for therelationship between those steroids and some respiratory parameters. Serum levels ofadrenal and gonadal steroids were measured in 52 age -and gender- matched subjects(28 ALS and 24 controls) using radioimmunoassay techniques. We also evaluatedrespiratory parameters in ALS patients [forced vital capacity FVC%, maximal inspiratorypressure MIP% and maximal expiratory pressure MEP% ] at the time of blood samplecollection. Steroid levels and ratios were correlated with respiratory parameters.Compared to controls, increased levels of testosterone were demonstrated in female ALSpatients. With increasing age, testosterone declined in controls but not in ALS patients.Dehydroepiandrosterone sulfate\/cortisol ratio showed a positive correlation with FVC%,MIP% and MEP%. Higher total testosterone and free testosterone, as well as lowerprogesterone\/free testosterone ratio levels, were associated with a rapid worsening of themonthly FVC%. The present study shows that circulating gonadal and adrenal steroids aredifferentially expressed in ALS patients relative to controls and that they could influencerespiratory outcome in patients. Dehydroepiandrosterone sulfate or progesterone mayprovide a protective function, while others like testosterone or cortisol probably have anegative influence.","palabras_clave":"PROGESTERONE|STEROIDS|PROGNOSIS|AMYOTROPHIC LATERAL SCLEROSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39316,"idioma_id":4,"titulo":"Incorporation of probiotic bacteria (Lactobacillus acidophilus and Bifidobacterium ssp.) in Argentinean ovine cheese","resumen":"The market of cheeses from ewe's milk has been growing steadily inArgentina. The nutritional benefits of these products can be enhanced by addingprobiotic cultures. In the present study, the survival of a mix of probioticmicroorganisms (Lactobacillus acidophilus La-5 and Bifidobacterium animalisssp. lactis Bb12) in a semi-hard ovine cheese, manufactured with a technologypreviously developed in our institute was evaluated. Besides, the effect of itsincorporation on the chemical composition and ripening parameters of cheeses,including the fatty acid composition and CLA production, was investigated.&nbsp;Experimental cheeses made withBb12 and La-5 retained counts of the probiotic strains at the requiredtherapeutic level (107 CFU g-1). No significant differenceswere detected between experimental and control cheeses with respect to the differentparameters evaluated: gross composition, nitrogen fractions, lipolysis, fattyacids profiles of cheese fat including CLA, and volatile fraction. Resultsdemonstrated that the ovine cheese matrix seems to be suitable for delivery ofprobiotic microorganisms.  ","palabras_clave":"ovine cheese|probiotic bacteria|proteolysis|lipolysis|CLA|volatile compounds"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39317,"idioma_id":4,"titulo":"An Observing System Simulation Experiment (OSSE) for the Aquarius\/SAC-D soil moisture product","resumen":"An Observing System Simulation Experiment for the Aquarius\/SAC-D mission has been developed for assessing the accuracy of soil moisture retrievals from passive L-band remote sensing. The implementation of the OSSE is based on the following: a 1-km land surface model over the Red-Arkansas River Basin, a forward microwave emission model to simulate the radiometer observations, a realistic orbital and sensor model to resample the measurements mimicking Aquarius operation, and an inverse soil moisture retrieval model. The simulation implements a zero-order radiative transfer model. Retrieval is performed by direct inversion of the forward model. The Aquarius OSSE attempts to capture the influence of various error sources, such as land surface heterogeneity, instrument noise and retrieval ancillary parameter uncertainty, all on the accuracy of Aquarius surface soil moisture retrievals. In order to assess the impact of these error sources on the estimated volumetric soil moisture, a quantitative error analysis is performed by comparison of footprint-scale synthetic soil moisture with ?true? soil moisture fields obtained from the direct aggregation of the original 1-km soil moisture field input to the forward model. Results show that, in heavily vegetated areas, soil moisture retrievals have a positive bias that can be suppressed with an alternative aggregation strategy for ancillary parameter vegetation water content (VWC). Retrieval accuracy was also evaluated when adding errors to 1-km VWC (which are intended to account for errors in VWC derived from remote sensing data). For soil moisture retrieval RMSE of the order of 0.05 m3=m3, error in VWC should be less than 12%.","palabras_clave":"Aquarius|Observing System Simulation Experiment|Soil Moisture"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39318,"idioma_id":4,"titulo":"Dystrophin proteolysis: a potential target for MMP-2 and its prevention by ischemic preconditioning","resumen":"ABSTRACT  Dystrophin is responsible for the mechanical stabilization of the sarcolemma and it has been shown that it is one of the most sensitive proteins to ischemic injury. However, the enzyme responsible for this proteolysis is still unknown. Isolated rabbit hearts were subjected to 30 minutes of global ischemia with and without reperfusion (180 minutes) to determine whether dystrophin is cleaved by MMP-2 during acute ischemia, and whether ischemic preconditioning (Pc) prevents dystrophin breakdown through MMP-2 inhibition. The activity of MMP-2 was evaluated by zymography and using doxycycline as an inhibitor. Also, to stimulate MMP-2 activity without ischemia, SIN-1 was administered in presence and in absence of doxycycline. Finally, we considered the Pc effect on the MMP-2 activity and the dystrophin expression. Dystrophin level decreased during ischemia, reaching 21% of control values (p <0.05), but spectrin level remained unchanged. MMP-2 activity increased 71% during ischemia compared with control values (p<0.05). Doxycycline administration before ischemia prevented dystrophin breakdown. In normoxic hearts, SIN-1 increased thiobarbituric acid reactive substances by 33% (p<0.05) and MMP-2 activity by 36% (p<0.05), and significantly reduced dystrophin level to 23% of control values (p<0.05). Pc significantly prevented dystrophin breakdown by inhibiting MMP-2 activity, and dystrophin level reached 89% of control values (p<0.05). Conclusions: MMP-2 could be responsible for the proteolysis of dystrophin. Thus, dystrophin emerges as a possible novel substrate for MMP-2 in the context of ischemic injury. Furthermore, our results demonstrate that ischemic preconditioning prevents dystrophin breakdown most likely by inhibiting MMP-2 activity.","palabras_clave":"Dystrophin|MMP-2|Myocardial infarction|Rabbits"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39319,"idioma_id":4,"titulo":"THYROTROPIN-RELEASING HORMONE (TRH) MAY MEDIATE SYMPATHETIC  ACTION AND ARTERIAL BLOOD PRESSURE INCREASE IN OFFSPRING OF MATERNAL OBESITY.","resumen":"        Landa MS, Schuman ML, Peres Diaz LS, Garcia  SI, Pirola CJ. THYROTROPIN-RELEASING  HORMONE (TRH) MAY MEDIATE SYMPATHETIC ACTION AND ARTERIAL BLOOD PRESSURE  INCREASE IN OFFSPRING OF MATERNAL OBESITY..&nbsp;  Hypertension. eLetters. Dallas: American Heart Association, Inc &nbsp;Available from: http:\/\/hyper.ahajournals.org\/content\/63\/2\/338\/reply#hypertensionaha_el_168  . 2014 April.  ","palabras_clave":"TRH|blood pressure|obesity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39320,"idioma_id":4,"titulo":"Soil nematode responses to fertilization with ammonium nitrate after six years of unfertilized apple orchard","resumen":"A nematode community was used as a bioindicator of changes in agroecosystems caused by fertilization. The effect of applying nitrogen (N) fertilizer on a soil nematode community structure was studied in a soil which had not been fertilized for six years in the Rio Negro Valley, Argentina. Treatments were: i) 100 kg N ha-1 (N100); ii) 200 kg N ha-1 (N200); in each case 50% of the dosage was applied at the time of petal fall and 50% at fruit harvest in 2004\/2005, 2005\/2006, 2006\/2007 growing seasons; and iii) control with no fertilizer (N0). Soil samples were collected in the 0 to 30 cm soil layer in October, November, April and July in each growing season. The number of bacterivores increased in N200 compared to N0. Cephalobidae were present in greater numbers in N200 than in N100 and N0. Predator abundance was lower under N200, after the first N application in each growing season. The ratio of fungivores to bacterivores (F\/B) was 0.21, 0.3 and 0.41 in N200, N100 and N0, respectively. N200 resulted in a community with a lower maturity index (MI) than N0. Structure index (SI) was lower in N200 than N100 and N0. The enrichment index (EI) was less sensitive at detecting fertilizer effects. In November and April, soil nitrate concentrations were higher in N200 than in N100 and N0. Soil nitrate concentration was positively correlated with EI and negatively with MI, SI and F\/B. N200 affected the trophic structure of the nematode community consistent with a less stable soil system.","palabras_clave":"ecological indices|soil food web|bioindicator|nitrogen fertilizer|Malus domestica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39321,"idioma_id":4,"titulo":"Average Deactivation Time of the Heterogeneous Reaction 2A + B2 --> 2AB","resumen":"In the present paper we exactly solve the distributed parameter stochastic model of the heterogeneous catalytic reaction 2A + B2 --&gt; 2AB and calculate the average number of reactive steps necessary to deactivate the lattice first,&lt; t &gt;. Results are compared with Monte Carlo simulations. &lt; t &gt; shows a nonmonotonic behavior with the sticking coefficient probability s and the desorption probability pd , reaching a maximum value that depends on s, pd and the lattice size N.","palabras_clave":"HETEROGENEOUS REACTION|DEACTIVATION TIME"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39322,"idioma_id":4,"titulo":"Oxygen assisted H2O dissociation on the Pt{110}(1x2) surface from first principles","resumen":"Water dissociation with and without oxygen coadsorption is investigated on the Pt{110}(1 × 2) surface at low coverage from first principles. Calculations indicate that desorption of the water molecule is likely to occur fromthe clean surface ahead of partial dissociation. The assistance of coadsorbed atomic O in the H2O partial dissociation changes the picture. Several H2O+O&#8594;OH+ OH possible reactions (with no OH+ H + O intermediate step) have been analyzed. The comparison between the activation energy for the mentioned reaction and the activation energy for H2O desorption shows no strong preference for one reaction over the other one.These results predict that the partial dissociation of H2O is a likely process if it is assisted by atomic O on the Pt {110}(1 × 2) surface. Dissociation and desorption of the H2O molecule are competitive processes on the surface and is possible to predict a dynamic system.","palabras_clave":"WATER MOLECULE|DENSITY FUNCTIONAL CALCULATIONS|METAL SURFACE|ADSORPTION|DESORPTION|DISSOCIATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39323,"idioma_id":4,"titulo":"Bulk-like behavior in the temperature driven martensitic transformation of Cu-Zn-Al thin films with 2H structure","resumen":"This paper reports on the possibility to obtain Cu?Zn?Al films with 2H martensitic structure by fixing thevalence electron concentration per atom (e\/a) &#1113099;1.53. Films with thickness of &#1113099;5 lm with micrometricgrains show martensitic transformation temperature and hysteresis values close to the ones found inbulk samples. This result is different to the one found in Cu?Zn?Al thin films with 18R martensitic struc-ture and similar microstructure, in which the hysteresis presents an increment (&#1113099;10 times) compared tobulk samples. This difference can be associated to the intrinsic nature of the 2H transformation whichrequires more undercooling to produce the nucleation of the martensitic phase. The driving force forthe burst-type martensitic transformation decreases the influence of the microstructure in thetransformation.","palabras_clave":"Shape memory|Thin Films"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39324,"idioma_id":4,"titulo":"The effects of agricultural management on the reproductive activity of female rodents in Argentina","resumen":"The aim of this study was to test if female rodents in border habitats of organic farms have higher reproductive activity than those of conventional farms in south-east Córdoba province, Argentina. The study was conducted in field borders of organic and conventional farms in 2012 and 2013 during the summer months, the time of the year when reproductive activity is more likely. We sampled field borders through a CMR trapping session and recorded vegetation cover, plant litter, vegetation volume, bare ground cover and land use of the field on both sides of the border (crop\/crop or crop\/pasture). We recorded the number of reproductive females and the rate of postpartum estrus. Green vegetation cover was higher in organic borders whereas plant litter was higher in borders of conventional farms. We used Generalized Linear Mixed Models (GLMM) to determine the factors that influence the number of reproductive females in borders of organic and conventional farms. The number of reproductive females was mainly determined by agriculture management and field type. There were more reproductive females in organic than in conventional borders, and borders associated with crop fields at both sides supported the highest number of reproductive females. The rate of postpartum estrus was higher in organic than in conventional borders. Our results showed that in border habitats of farms under organic management reproductive activity of female rodents was higher than in borders of conventional farms. Organic farm borders may provide high quality habitats that provide resources for reproduction and persistence of rodent populations.","palabras_clave":"Organic vs. conventional farms|Border habitat |Habitat quality|Rodent populations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39325,"idioma_id":4,"titulo":"Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties","resumen":"Gluconic acid is produced in large quantities by the endophytic and diazotrophic bacterium Gluconacetobacter diazotrophicus PAL5. This organic acid derives from the direct oxidation of glucose by means of a pyrroloquinoline quinone-linked glucose dehydrogenase in this plant growth-promoting microorganism. In this article evidence is presented showing that gluconic acid is also responsible for the antimicrobial activity of G. diazotrophicus PAL5. The broad antagonistic spectrum includes Grampositive and -negative bacteria. Eukaryotic microorganisms are more resistant to the growth inhibition by this acid. The inhibition by gluconic acid can be modified through the presence of other organic acids. In contrast to other microorganisms, the quorum sensing system of G. diazotrophicus PAL5, a regulatory mechanism that plays a key role in several microbe-microbe interactions, is not related to the gluconic acid production and the concomitant antagonistic activity.","palabras_clave":"GLUCONACETOBACTER DIAZOTROPHICUS|GLUCONIC|ANTIMICROBIAL|ANTAGONISM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39326,"idioma_id":4,"titulo":"Experimental evidence and modeling of non-monotonic responses in MOS dosimeters","resumen":"The evolution of the threshold voltage of MOS dosimeters during   irradiation under switched bias is investigated with the aim of using   the sensors with a new biasing technique. The devices response to a bias   change does not only depend on the instant threshold voltage and bias,   and may lead to non-monotonical behavior under fixed bias following the   switch. This work shows experimental evidence for this effect and   presents a simple model based on oxide charge buildup and   neutralization. The proposed model reproduces the experimental data   assuming the existence of two types of hole traps in the oxide. Physical   interpretations of the results are discussed.","palabras_clave":"MOS |DOSIMETERS|MODELING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39327,"idioma_id":4,"titulo":"Switched bias differential MOSFET dosimeter","resumen":"This paper presents a differential MOSFET sensor reading technique based on the bias controlled cycled measurement. The circuit was implemented, and tested with gamma radiation from a 60-cobalt source. Temperature rejectionperformance was assessed during the exposure in real-time measurements. The results show that in comparison with a single MOSFET dosimeter the thermal drift is 20 times smaller and the radiation sensitivity is approximately 10% higher. The switched biasing allows to extend the measurement range beyond MOSFET?s threshold voltage saturation.","palabras_clave":"MOSFET dosimeter|Radiation effects|MOS sensors|Solid-state detectors"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39328,"idioma_id":4,"titulo":"Zoledronate and Related Impurities Analysis by Capillary Zone Electrophoresis","resumen":"A capillary zone electrophoretic (CZE) method has been developed for the   determination of zoledronate and its related impurities (phosphyte and   phosphate). Successful separation of the drug from the impurities was   achieved using 7.5 mM of phthalic acid adjusted to pH 3.50 with TRIS, as   background electrolyte with an indirect detection at 205 nm. The   optimized method was validated for specificity, precision, linearity and   accuracy. The limit of detection was 1.8 µg ml-1 and the limit of quantification was 5.9 µg ml-1 for phosphyte. The limit of detection was 2.8 µg ml-1 and the limit of quantification was 9.3 µg ml-1   for phosphate. The developed CZE method used to determine zoledronate,   phosphyte and phosphate as bisphosphonates impurities can be used to   evaluate the quality of regular production samples of zoledronate.","palabras_clave":"ZOLENDRONATE|CAPILARRY ELECTROPHORESIS|IMPURITIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39329,"idioma_id":4,"titulo":"Removal of azo dyes from water by sol-gel immobilized Pseudomonas sp","resumen":"  Water pollution control is presently one of the major scientific research areas. Sol-gel immobilized Pseudomonas sp. able to enzymatically reduce azo groups was used for the decolourization of water containing azo dyes. It was observed that immobilized bacteria produced more than seven times higher amounts of extracellular enzymes involved in the biodegradation of azo dyes. The reusability of the immobilized bacteria was successfully evaluated with repeated-batch decolourization experiments. Indeed, after four repeated experiments, the decolourization was over 75%, 79% and 83% for remazol black, methyl orange and bencyl orange, respectively. The herein sol-gel immobilized bacteria offer advantages such as high viable cell densities, high stability and extended reaction times. Thus it would be applied as a cost-effective and efficient treatment to remove dyes from effluents.Pseudomonas sp. able to enzymatically reduce azo groups was used for the decolourization of water containing azo dyes. It was observed that immobilized bacteria produced more than seven times higher amounts of extracellular enzymes involved in the biodegradation of azo dyes. The reusability of the immobilized bacteria was successfully evaluated with repeated-batch decolourization experiments. Indeed, after four repeated experiments, the decolourization was over 75%, 79% and 83% for remazol black, methyl orange and bencyl orange, respectively. The herein sol-gel immobilized bacteria offer advantages such as high viable cell densities, high stability and extended reaction times. Thus it would be applied as a cost-effective and efficient treatment to remove dyes from effluents.","palabras_clave":"BIORREMEDIATION|SOL-GEL|DYES|IMMOBILIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39330,"idioma_id":4,"titulo":"Two CCAAT-box-binding transcription factors redundantly regulate early steps of the legume-rhizobia endosymbiosis","resumen":"During endosymbiotic interactions between legume plants and nitrogen-fixing rhizobia, successful root infection by bacteria and nodule organogenesis requires the perception and transduction of bacterial lipo-chitooligosaccharidic signal called Nod factor (NF). NF perception in legume roots leads to the activation of an early signaling pathway and of a set of symbiotic genes which is controlled by specific early transcription factors (TFs) including CYCLOPS\/IPD3, NSP1, NSP2, ERN1 and NIN. In this study, we bring convincing evidence that the Medicago truncatula CCAAT-box-binding NF-YA1 TF, previously associated with later stages of rhizobial infection and nodule meristem formation is, together with its closest homolog NF-YA2, also an essential positive regulator of the NF-signaling pathway. Here we show that NF-YA1 and NF-YA2 are both expressed in epidermal cells responding to NFs and their knock-down by reverse genetic approaches severely affects the NF-induced expression of symbiotic genes and rhizobial infection.Further over-expression, transactivation and ChIP-PCR approaches indicate that NF-YA1 and NF-YA2 function, at least in part, via the direct activation of ERN1. We thus propose a model in which NF-YA1 and NFYA2 appear as early symbiotic regulators acting downstream of DMI3 and NIN and possibly within the same regulatory complexes as NSP1\/2 to directly activate the expression of ERN1.","palabras_clave":"TRANSCRIPTION FACTOR|NUCLEAR FACTOR Y|SYMBIOSIS|NOD FACTOR SIGNALING|CCAAT BINDING FACTOR|MEDICAGO TRUNCATULA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39331,"idioma_id":4,"titulo":"Point of zero charge as a factor to control biofilm formation of Pseudomonas aeruginosa in sol-gel derivatized aluminum alloy plates","resumen":"The hospital environment is particularly susceptible to   contamination by bacterial pathogens that grow on surfaces as biofilms.   An increased risk of disease may be a direct consequence of their   formation. Understanding bacterial adhesion to surfaces could be of   special interest in order to avoid biofilm formation.  In   this work, aluminum alloys plates were modified by coating them with   organosilanes via the sol-gel process in order to get surfaces with   different points of zero charge (PZC). These coatings were homogeneous,   with smooth surface and reduced metal corrosion. These modified surfaces   were investigated to elucidate their effects on bacterial retention at   two different times of a strain of Pseudomonas aeruginosa at   different pHs. Bacterial retention revealed significant differences   between the coated surfaces. Surfaces with low PZC showed a low   bacterial retention due to electrostatic repulsion. On the other hand,   surfaces with high PZC presented a distinct behavior: bacterial   retention increased with pH due to the image charge generated in the   metal surfaces. According to these results, when biofilm formation is   undesired, the use of low PZC surfaces is the best choice since they   showed low attachment efficiency in bacterial retention.","palabras_clave":"SOL-GEL|BACTERIAL RETENTION|POINT OF ZERO CHARGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39332,"idioma_id":4,"titulo":"TEOS as an improved alternative for chitosan beads cross-linking: A comparative adsorption study","resumen":"In this work the use of tetraethoxysilane (TEOS) for cross-linking of chitosan hydrogel beads was studied at the level of 1 mmol TEOS per gram of chitosan. They were compared with glutaraldehyde and epichlorohydrin cross-linked beads. The hydrogels were characterized by FTIR, SEM, water content, nitrogen content, and their point of zero charge. The performance of the anionic dye Remazol Black (RB) and the cationic Cd(II) adsorptions was assessed in order to characterize the sorbate?sorbent interaction. Adsorption experimental data were analyzed using two- and three-parameter isotherm models along with the evaluation of mean adsorption energy and standard free energy. The adsorption was observed to be pH dependent. The uptake rate of RB and Cd(II) showed that the three type of beads followed a similar kinetic behavior. For both sorbates the TEOS cross-linked beads showed the higher maximum adsorption capacity, followed by epichlorohydrin and glutaraldehyde cross-linked beads.","palabras_clave":"ADSORPTION|CROSSLINKING|KINETICS|POLYSACHARIDES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39333,"idioma_id":4,"titulo":"VIP induces an immunosuppressant microenvironment in the maternal-fetal interface of non obese diabetic (NOD) mice and improves pregnancy outcome","resumen":"Problem: Impaired pregnancy in non obese diabetic (NOD) mice was related to limited  vascular remodeling and autoimmune background. Vasoactive intestinal peptide (VIP)  has anti-inflammatory and immunosuppressant effects so we explored its ability to  modulate the immune microenvironment at the early maternal-placental interface and  improve pregnancy in NOD mice.  Method of Study: Implantation sites were isolated from pregnant NOD mice at  gestational day 9,5 and were incubated with VIP for evaluation of cytokine or  transcription factor expression by RT-PCR, immunoblotting and  immunohistochemistry. Alternatively, pregnant mice were injected with VIP at day 6,5  and studied at day 9,5.  Results: VIP and VPAC receptors were detected in viable implantation sites. VIP  immunostaining was found predominantly on trophoblast giant cells. The in vitro  treatment of viable implantation sites with VIP increased IL-10, TGF-&#946; and Foxp3  expression. Sites with resorption processes presented lower VIP expression, reduced  suppressant markers and increased IL-17 and ROR&#947;T expression compared with viable  sites and VIP reduced ROR&#947;T expression. Pregnant mice treated with VIP at day 6,5  presented an even distribution of viable implantation sites with an increased expression  of IL-10, TGF- &#946; and Foxp3.  Conclusions: VIP induces an immunosuppressant profile at the early maternal-placental  interface of NOD mice and improves pregnancy outcome.","palabras_clave":"VIP|early pregnacy|NOD mice|IL-10|FOXP3|TGF-B"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39334,"idioma_id":4,"titulo":"Surface barriers of mandarin cv. 'Okitsu' leaves make a major contribution to canker disease resistance","resumen":"Field evaluations have shown that Satsuma mandarin (Citrus unshiu) cv. ´Okitsu´ is one of the mandarin cultivars that shows substantial resistance to Xanthomonas citri subsp. citri (X. citri), the causal agent of citrus bacterial canker disease. However, the mechanisms underlying this resistance are not well understood. In this study we have shown that ´Okitsu´ leaves are nevertheless susceptible to X. citri infection during a period of their development, but this period is shorter than that seen in the susceptible mandarin cv. ´Clemenules´ (Citrus clementina). Under controlled growth conditions the resistance of ´Okitsu´ cultivar to X. citri was associated with the age of the leaf, and was evident in spray-inoculated plants but not in those inoculated by infiltration. Furthermore, X. citri showed reduced attachment and biofilm formation in ´Okitsu´ leaves as compared to ´Clemenules´. Taken together, our data suggest that structural features of the ´Okitsu´ leaf surface, such as the physical properties of the cuticle, are involved in the resistance to X. citri.","palabras_clave":"Canker resistance|X. citri|Citrus unshiu cv. 'Okitsu'|phenological stages|leaf surface properties|biofilm formation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39335,"idioma_id":5,"titulo":"RASGOS MORFOSEDIMENTARIOS, PROCESOS Y EVOLUCIÓN DE LA PLATAFORMA CONTINENTAL ARGENTINA DESDE EL ÚLTIMO MÁXIMO GLACIAL","resumen":"La plataforma continental argentina es una de las plataformas submarinas más extensas del mundo, localizada en un contexto  geotectónico dominado por un margen continental pasivo, aunque en su porción más austral se asocia a sectores de márgenes  activos. Su extensión y escaso relieve han favorecido un profundo efecto modelador producto de las sucesivas transgresiones  y regresiones marinas del Cuaternario, que le imprimieron variados rasgos morfosedimentarios. La transgresión postglacial  dejó los rasgos finales que pueden ser reconocidos en las características superficiales y subsuperficiales, como ser las terrazas  escalonadas asociadas a variaciones en la velocidad de ascenso del nivel del mar así como evidencias de paleolíneas de costas  hoy sumergidas. Numerosos rasgos demuestran aspectos de la exposición subaérea durante el Último Máximo Glacial, como  relictos de redes fluviales, depósitos glacifluviales y remanentes de suelos. La acción conjunta de los procesos actuantes favoreció  la redistribución de los sedimentos aportados por la erosión de las sucesivas líneas de costas durante los avances y retrocesos  marinos, además de aquellos incorporados desde el continente por acción eólica y fluvial. De esta manera, la cobertura  sedimentaria resultante es terrígena de tipo relíctico y palimpséstico. Las características del borde exterior de la plataforma en  transición al talud demuestran complejos procesos tanto litorales (durante etapas de bajo nivel del mar) como profundos (erosión  retrocederte asociada a la dinámica de cañones submarinos), mientras que la disposición diferente de las terrazas entre los  sectores bonaerense y patagónico de la plataforma estaría asociada a ajustes hidroisostáticos.","palabras_clave":"Margen continental|postglacial,|fluctuaciones del nivel del mar|procesos sedimentarios, margen continental;"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39336,"idioma_id":4,"titulo":"Regulatory Volume Increase and Regulatory Volume Decrease Responses in HL-1 Atrial Myocytes","resumen":"Background\/Aims: we have investigated whether cultured cardiomyocytes of   the cell line HL-1 have the ability to perform regulatory volume responses both in hypotonic and hypertonic conditions. Furthermore, we characterized those regulatory responses and studied the effects of bumetanide and DIDS in volume regulation of HL-1 cells. Methods: we used a light scattering system to measure the transient volume changes of HL-1 cells when subjected to osmotic challenge. Results: We found that HL-1 cells correct for their volume excess by undergoing regulatory volume decrease (RVD), and also respond to hypertonic stress with a   regulatory volume increase (RVI). Rate of RVD was 0.08 ± 0.04 intensity\/min, and rate of RVI was 0.09 ± 0.01 intensity\/min. Volume recovery was 83.68 ± 5.73 % for RVD and 92.3 ± 2.3 % for RVI. Bumetanide 50 µM inhibited volume recovery, from 92.3 ± 2.3 % (control) to 24.6 ±   8.8 % and reduced the rate of RVI from 0.070 ± 0.020 intensity\/min (control) to 0.010 ± 0.005 intensity\/min. 50 µM DIDS reduced volume recovery to 42.93 ± 7.7 % and rate of RVI, to 0.03 ± 0.01 intensity\/min. Conclusions: these results suggest that bumetanide- and DIDS-sensitive mechanisms are involved in the RVI of HL-1 cells, which points to the   involvement of the Na cotransporter and Cl bicarbonate exchanger in RVI, respectively.","palabras_clave":"CELLULAR VOLUMEN|HL-1 CARDIAC CELL|HYPOTONIC CONDITIONS|HYPERTONIC CONDITIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39337,"idioma_id":4,"titulo":"Interpretation of experimental results on Kondo systems with crystal field","resumen":"We present a simple approach to calculate the thermodynamic properties  of single Kondo impurities including orbital degeneracy and crystal field effects (CFE) by extending a previous proposal by K. D. Schotte and U. Schotte [Physics Lett. 55A, 38 (1975)]. Comparison with exact solutions for the specific heat of a quartet ground state split into two doublets shows deviations below 10 % in absence of CFE and a quantitative agreement for moderate or large CFE. As an application, we fit the measured specific heat of the compounds CeCu2Ge2, CePd3Si0.3, CePdAl, CePt, Yb2Pd2Sn and YbCo2Zn20. The agreement between theory and experiment is very good or excellent depending on the compound, except at very low temperatures due to the presence of magnetic correlations (not accounted in the model).","palabras_clave":"Kondo Effect|Crystal Field Effects|Magnetism"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39338,"idioma_id":4,"titulo":"Five Poems from Juan Gelman?s Hoy","resumen":"Translations from Juan Gelman´s last book of verse.","palabras_clave":"poetry|translation|exile|memory"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39339,"idioma_id":5,"titulo":"Áreas persistentes de entierro en cazadores-recolectores del Noroeste de Patagonia: sitio Hermanos Lazcano (Chos Malal, Neuquén)","resumen":"En este trabajo se presenta la caracterización bioarqueológica del sitio Hermanos Lazcano y se discuten los resultados en relación con el registro bioarqueológico regional. Se estableció el estado de preservación ósea, la composición sexual y etaria de la muestra, la cronología y la presencia de modificaciones intencionales del cráneo. Se trata de un entierro  múltiple de 3780 años AP, compuesto por un número mínimo de 4 subadultos y 8 adultos de ambos sexos. El conjunto óseo presenta elevado índice de fragmentación y pobre estado de conservación. Se determinó la presencia de modificación del cráneo circular y pseudocircular. El material cultural comprende bases de molino, cuentas y un colgante de valva, una esfera lítica y litos trapezoidales. Estos resultados indican que el surgimiento de áreas de entierro con alta concentración de individuos se habría producido en los grupos cazadores-recolectores del norte neuquino en momentos más tempranos que en otras regiones patagónicas.","palabras_clave":"Bioarqueología|Holoceno tardío inicial|Prácticas mortuorias|Entierros múltiples"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39340,"idioma_id":4,"titulo":"Predictive role of polymerase chain reaction in the early diagnosis of congenital Trypanosoma cruzi infection","resumen":"The efficacy of specific chemotherapy in congenital Chagas disease before the first year of life ranges between 90 and 100%. Between this age and 15 years of age, the efficacy decreases to around 60%. There- fore, early infection detection is a priority in vertical transmission. The aim of this work was to assess whether polymerase chain reaction (PCR) plays a predictive role in the diagnosis of congenital Chagas disease as compared to conventional parasitological and serological methods. To this end, we studied a total of 468 children born to Trypanosoma cruzi seroreactive mothers came from Argentina, Bolivia and Paraguay, who lived in the city of Buenos Aires and suburban areas (Argentina), a non-endemic area of this country. These children were assessed by PCR from 2004 to 2009 with the specific primers Tcz1 and Tcz2, and 121 and 122. PCR allowed detecting 49 T. cruzi-positive children. Eight of these 49 children were excluded from the analysis: six because they did not complete follow-up and two because the first control was performed after 12 months of age. Parasitological methods allowed detecting 25 positive children, 7 of whom had been earlier diagnosed by PCR (1.53 ± 2.00 vs. 6.71 ± 1.46 months; p = 0.0002). Serological methods allowed detecting 16 positive children, 12 of whom had been earlier diagnosed by PCR (1.46 ± 1.48 vs. 11.77 ± 4.40 months; p < 0.0001). None of the children negative by PCR was positive by serological or parasitological methods. This study shows that PCR allows early diagnosis in congenital Chagas disease. At present, an early positive PCR is not indicative for treatment. However, a positive PCR would alert the health system to search only those infected infants diagnosed by early PCR and thus generate greater efficiency in the diagnosis and treatment of congenital T. cruzi infection.","palabras_clave":"Trypanosoma cruzi|Congenital infection|Congenital Chagas disease|Predictive diagnosis by PCR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39341,"idioma_id":4,"titulo":"First llama (Lama glama) pregnancy obtained after in vitro fertilization and in vitro culture of gametes from live animals","resumen":"The aim of this study was to evaluate the developmental competence and pregnancy rate of llama hatched blastocysts produced in vitro using gametes from live animals and two different culture conditions. Fifteen adult females were superstimulated with 1500 IU of eCG, eleven (73%) responded to the treatment and were used as oocyte donors. Follicular aspiration was conducted by flank laparotomy. Semen collections were performed under general anesthesia by electroejaculation of the male. Sixty-six COCs were recovered from 77 aspirated follicles (86% recovery) and were randomly placed in Fertil-TALP microdroplets with the sperm suspension (20 × 10(6)live spermatozoa\/ml). After 24 h, they were placed in SOFaa medium supplemented with FCS and randomly assigned to one of two culture conditions. Culture condition 1 (CC1) consisted of 6 days of culture (n=28) and culture condition 2 (CC2) consisted of renewing the culture medium every 48 h (n=35). In CC1, the blastocyst rate was 36% (10\/28) and the hatched blastocyst rate was 28% (8\/28) whereas in CC2, the blastocyst rate was 34% (12\/35) and the hatched blastocyst rate was 20% (7\/35) (p>0.05). No pregnancies were obtained after embryo transfer (ET) of CC1 blastocysts (0\/8) while one pregnancy was obtained (1\/7) after transferring a hatched blastocyst from CC2. Forty-two days after the ET, the pregnancy was lost. This study represents the first report of a pregnancy in the llama after intrauterine transfer of embryos produced by in vitro fertilization using gametes from live animals.","palabras_clave":"Embryo |IVC| IVF|Llama"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39342,"idioma_id":5,"titulo":"Puesta en valor de una escuela patrimonial en zona de alto riesgo sísmico: un caso de estudio","resumen":"La Escuela Mitre es un edificio educacional monumental, habilitado en 1906, de mampostería cerámica cocida sin encadenar. Durante su vida útil ha sufrido daños debido a los terremotos impulsivos de Mendoza, Argentina, a los cambios en los materiales y a la falta de mantenimiento. La metodología de estudio ha incluido las siguientes etapas: una inspección detallada, las decisiones de emergencia, el análisis de las condiciones de conservación del edificio, el diagnóstico y las alternativas de rehabilitación. Con los datos de campo y de laboratorio, se ha modelado el edificio mediante elementos finitos. Las ventajas del uso del hormigón en la rehabilitación es lograr el menor costo y el mejor desempeño estructural de acuerdo con las normas de rehabilitación vigentes, pero desde el punto de vista patrimonial, se ha preferido la combinación de estructuras de acero que no interfieren con la fábrica original y la rehabilitación de fundaciones con hormigón armado","palabras_clave":"patrimonio|seguridad|sismorresistente|puesta en valor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39343,"idioma_id":4,"titulo":"Is Munida gregaria (Crustacea: Decapoda: Munididae) a truly transpacific species?","resumen":"                The ?East Pacific Barrier? has been recognized as the  World´s largest marine biogeographic &nbsp;barrier.  Munida gregaria is the only species of its family with transpacific  populations; however, it still remains to be elucidated whether these two distantly  located populations belong to the same species. In this study we investigated  the genetic cohesion of M. gregaria across the East Pacific Barrier by  analyzing mitochondrial markers. COI and ND1 genes were sequenced for  individuals from eight localitiesdifferent areas, i.e. one in the South East Pacific,  two in the South southern tip of South America, East Pacific\/the South West  Atlantic, four in the South West Atlantic, and one in the South West Pacific. A  median-joining network, AMOVA, pairwise FSTs,  genetic diversity statistics and neutrality tests were computed. Our results,  i.e. absence of different haplogroups on both sides of the East Pacific Barrier  and existence of shared haplotypes, showed that populations on both sides of  this barrier belong to the same species. At a population genetic level, our  results suggest that individuals from both regions have been connected, since  although some differentiation was found between the southern tip of South  America and the South West Pacific, the South East Pacific and South West  Atlantic showed no signs of differentiation from the South West Pacific. The  analyses performed showed no genetic differentiation between transpacific populations  of M. gregaria suggesting that there has been enough gene flow to maintain  species cohesion. In addition, our results provided evidence of a spatial  expansion in southern South America during the Middle Pleistocene. The role of  Pleistocene glaciations and the Antarctic Circumpolar Current in shaping the  distribution of sub-Aantarctic marine invertebrates is discussed. Overall, Munida  gregaria constitutes a truly transpacific species.  ","palabras_clave":"marine biogeography|squat lobsters|East Pacific Barrier|Antarctic Circumpolar Current"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39344,"idioma_id":4,"titulo":"Quark deconfinement in high-mass neutron stars","resumen":"In this paper, we explore whether or not quark deconfinement may occur in  high-mass neutron stars such as J1614-2230 (1.97 pm 0.04 M_Sun) and J0348+0432  (2.01 pm 0.04 M_Sun). Our study is based on a non-local extension of the SU(3)  Nambu Jona-Lasinio (n3NJL) model with repulsive vector interactions among the  quarks. This model goes beyond the frequently used local version of the Nambu  Jona-Lasinio model by accounting for several key features of QCD which are not  part of the local model. We find that the n3NJL model predicts the existence of  an extended region of a mixed phase of quarks and hadrons (quark-hybrid matter)  in high-mass neutron stars of masses up to around 2.1 M_Sun. Central stellar  cores made of pure quark matter are not obtained. The radii of high-mass  neutron stars with quark-hybrid matter in their centers are found to lie in the  canonical range of 12 to 13 km.","palabras_clave":"Quark Matter|Hybrid Stars"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39345,"idioma_id":5,"titulo":"HELMINTOS ZOONOTICOS EN HECES CANINAS DE BARRIOS DE BARILOCHE (RIO NEGRO, PATAGONIA, ARGENTINA)","resumen":"El objetivo de este trabajo fue realizar un relevamiento preliminar en Bariloche (Patagonia, Argentina), de helmintos endoparásitos en heces caninas en barrios con distintas Características socioeconómicas y culturales. En 2011 y 2013, se colectaron heces caninas en 5 barrios y se fraccionaron para su análisis por técnicas directas e indirectas. Se identificaron un total de 10 especies de helmintos, detectándose por análisis directos al cestode Diphyllobothrium sp y a los nematodes Strongyloides sp. Uncinaria sp., Ancylostoma sp., Toxocara sp., Toxascaris sp., Capillaria sp. y Trichuris sp. A través de análisis indirectos se detectaron dos especies de cestodes: Echinococcus granulosus y Taenia sp. El número de especies registradas por barrio varió entre 0 y 6, Trichuris sp. presentó el porcentaje más alto de infección (77%) y Strongyloides sp. fue el parásito más distribuido ocurriendo en 4 de los 5 barrios. En el único barrio muestreado en los 2 años, se registró en ambos muestreos la presencia tanto de E. granulosus como de Diphyllobothrium sp. El hallazgo repetido de diferentes especies parásitas en los distintos barrios, en años alternados de muestreo, indica un patrón de circulación de las parasitosis sostenido por prácticas culturales en un contexto social donde no hay adecuada educación sanitaria, control ni monitoreo. La presencia de equinococosis y de difilobotriosis en perros urbanos se cita por primera vez para la ciudad de Bariloche.","palabras_clave":"HECES |DIPHYLLOBOTHRIUM|ECHINOCOCCUS|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39346,"idioma_id":4,"titulo":"Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury","resumen":"Following spinal cord injury (SCI), semaphorin 3A (Sema3A) prevents axonal regeneration through binding to the neuropilin-1 (NRP-1)\/PlexinA4 receptor complex. Here, we show that galectin-1 (Gal-1), an endogenous glycan-binding protein, selectively bound to the NRP-1\/PlexinA4 receptor complex in injured neurons through a glycan-dependent mechanism, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI. Although both Gal-1 and its monomeric variant contribute to de-activation of microglia, only high concentrations of wild-type Gal-1 (which co-exists in a monomer-dimer equilibrium) bind to the NRP-1\/PlexinA4 receptor complex and promote axonal regeneration. Our results show that Gal-1, mainly in its dimeric form, promotes functional recovery of spinal lesions by interfering with inhibitory signals triggered by Sema3A binding to NRP-1\/PlexinA4 complex, supporting the use of this lectin for the treatment of SCI patients.","palabras_clave":"SPINAL CORD INJURY|GALECTIN|NEURONS|NEUROPILIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39347,"idioma_id":4,"titulo":"Effects of Phyllanthus sellowianus Müll Arg. extracts on the rheological properties of human erythrocytes","resumen":"Phyllanthus sellowianus extracts have been used in Argentina since colonial times in the treatment of diabetes. The in vitro biorheological and hemoagglutinant action of different extracts of Phyllanthus sellowianus bark on human erythrocytes (RBC) were studied. RBCs were incubated in vitro with four aqueous extracts: Maceration (PM); Controlled Digestion (PD); Decoction (PC) and Infusion (PI). Biorheological parameters (deformability, membrane surface viscosity, elastic modulus and dynamic viscolelasticity) were determined with an Erythrodeformeter and erythrocyte adhesion was characterized by image digital analysis. Immunohematological assays in RBC incubated with all the extracts showed large globular aggregates and agglutination in human ABO blood group system. Isolated cell coefficient (CCA) showed the increase of cell adhesion. Aggregated shape parameters (ASP) were significantly higher than normal and they changed with the concentration, particularly of PD extracts. Rheological results showed that the extract biorheological action varies with the temperature used in the extract preparations. The results obtained are useful to study the action mechanism of extracts from Phyllanthus sellowianus bark in order to evaluate its use as therapeutic agent in Diabetes. Immunohematological Tests using ABO system showed its agglutinant power, which is of special interest in Immunohematology to be used as hemoclassifier.","palabras_clave":"MEDICAL PLANTS|PHYLLANTHUS SELLOWIANUS |DIABETES|HEMORREOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39348,"idioma_id":4,"titulo":"Floquet chiral edge states in graphene","resumen":"We report on the emergence of laser-induced chiral edge states in   graphene ribbons. Insights on the nature of these Floquet states is   provided by an analytical solution which is complemented with numerical   simulations of the transport properties. Guided by these results we show   that graphene can be used for realizing nonequilibrium topological   states with striking tunability: while the laser intensity can be used   to control their velocity and decay length, changing the laser   polarization switches their propagation direction.","palabras_clave":"GRAPHENE|FLOQUET|QUIRAL|EDGE STATES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39349,"idioma_id":4,"titulo":"Anti-inflammatory and antioxidant activities, functional properties and mutagenicity studies of protein and protein hydrolysate obtained from Prosopis alba seed flour","resumen":"Prosopis species are considered multipurpose trees and shrubs by FAO and their fruit constitute a food  source for humans and animals. According to the ??Código Alimentario Argentino??, ??algarrobo flour?? is  produced by grinding the whole mature pod, but in the traditional process most of the seeds are discarded.  In this paper, the flour from seed was obtained. Then, the proteins were extracted and enzymatic  hydrolysis was carried out. According to their amino acid profile and chemical score (&gt;100%), the Prosopis  alba proteins, are not deficient in essential amino acids considering the amount of amino acid necessary  by adults. The protein isolate showed a good solubility (pH 7.4?9), emulsificant capacity, oil binding  capacity and water adsorption capacity. The antioxidant ability of proteins was significantly increased  with hydrolysis (SC50 values: 50?5 lg\/mL, respectively). Inhibitory activity of pro-inflammatory enzymes  (lipoxygenase and phospholipase) was described. The mutagenicity\/antimutagenicity of proteins and  protein hydrolysates from seed flour were also analysed.  The results suggest that P. alba cotyledon flour could be a new alternative in the formulation of functional  foods not only for its high protein content but also by the biological and functional properties of its  proteins and protein hydrolysates","palabras_clave":"Prosopis alba|seed|protein isolate|biological properties"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39350,"idioma_id":4,"titulo":"Differential growth responses to sodium salts involve different abscisic acid metabolism and transport in Prosopis strombulifera","resumen":"In this work, the response of the halophytic shrub Prosopis strombulifera to lowering an osmotic potential (&#936;o) to-1.0, -1.9, and -2.6 MPa generated by NaCl, Na2SO4, and the iso-osmotic combination of them was studied at 6, 12, and24 h after reaching such values in the growing media. By analyzing the content of abscisic acid (ABA) and relatedmetabolites and transpiration rates, we observed that ABA content varied depending on type of salt, salt concentration,organ analyzed, and age of a plant. ABA content in leaves was much higher than in roots, presumably because of rapidbiosynthesis and transport from roots. Leaves of Na2SO4-treated plants had the highest ABA content at &#936;o -2.6 MPa(24 h) associated with sulfate toxicity symptoms. Significant content of ABA-glucose ester (ABA-GE) was found inboth the roots and leaves, whereas only low content of phaseic acid (PA) and dihydrophaseic acid (DPA). The rootsshowed high ABA-GE accumulation in all treatments. The highest content of free ABA was correlated with ABA-GEglucosidase activity. The results show that ABA-GE and free ABA work together to create a specific stress signal.","palabras_clave":"ABSCISIC ACID GLUCOSE ESTER|DIHYDROPHASEIC ACID|HALOPHYTE|OSMOTIC POTENTIAL-SALINITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39351,"idioma_id":4,"titulo":"CD4(+) CD25(high) forkhead box protein 3(+) regulatory T lymphocytes suppress interferon-&#947; and CD107 expression in CD4(+) and CD8(+) T cells from tuberculous pleural effusions.","resumen":"Tuberculous pleural effusion is characterized by a T helper type 1 (Th1)  profile, but an excessive Th1 response may also cause tissue damage that  might be controlled by regulatory mechanisms. In the current study we  investigated the role of regulatory T cells (Treg) in the modulation of Th1 responses in patients with tuberculous (TB) pleurisy. Using flow cytometry we evaluated the proportion of Treg (CD4+CD25highforkhead box protein 3+),interferon (IFN)-&#947; and interleukin (IL)-10 expression and CD107 degranulation in peripheral blood (PB) and pleural fluid (PF) from patients with TB pleurisy. We demonstrated that the proportion of CD4+CD25+,CD4+CD25highFoxP3+ and CD8+CD25+ cells were increased in PF compared to PB samples. Mycobacterium tuberculosis stimulation increased the proportion of CD4+CD25low\/&#8722;IL-10+ in PB and CD4+CD25low\/&#8722;IFN-&#947;+ in PF; meanwhile,CD25high mainly expressed IL-10 in both compartments. A high proportion of CD4+CD107+ and CD8+CD107+ cells was observed in PF. Treg depletion enhanced the in-vitro M. tuberculosis-induced IFN-&#947; and CD4+ and CD8+ degranulation responses and decreased CD4+IL-10+ cells in PF. Our results demonstrated that in TB pleurisy Treg cells effectively inhibit not only IFN-&#947; expression but also the ability of CD4+ and CD8+ cells to degranulate in response to M. tuberculosis.","palabras_clave":"CD107|pleural effusions|T regulatory|tuberculosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39352,"idioma_id":4,"titulo":"Optimal nondiscriminatory auctions with favoritism","resumen":"In many auction settings, there is favoritism: the seller´s welfare depends positively on the utility of a subset of potential bidders. However, laws or regulations may not allow the seller to discriminate among bidders. We find the optimal nondiscriminatory auction in a private value, single-unit model under favoritism. At the optimal auction there is a reserve price, or an entry fee, which is decreasing in the proportion of preferred bidders and in the intensity of the preference. Otherwise, the highest-valuation bidder wins. We show that, at least under some conditions, imposing a no-discrimination constraint raises expected seller revenue.","palabras_clave":"AUCTIONS|FAVORITISM|NONDISCRIMINATORY MECHANISMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39353,"idioma_id":4,"titulo":"Macroinvertebrates select complex macrophytes  independently of their body size and fish  predation risk in a Pampean stream","resumen":"Macrophyte complexity has been associated with high abundance and richness of macroinvertebrates. While the effect on richness has been attributed to an increase in the number of niches, the effect on abundance has been explained by a higher availability of space for small individuals, refuge and\/or food. For studying effects of complexity on macroinvertebrates we used complementary approaches of laboratory choice and field colonization experiments, with macrophytes (Egeria densa and Elodea ernstae) and plastic imitations of contrasting fractal dimension. We investigated whether macroinvertebrates may actively select complex habitats by Hyalella sp. choice experiments. Then, we tested effects of complexity on macroinvertebrate density, biomass, richness, diversity and body size using colonization experiments. Finally, a caging experiment was performed to study interacting effects of complexity and predation. The active choice of complex substrates by Hyalella sp., and the significant positive relationship between macrophyte fractal dimension and macroinvertebrate density supports the existence of a positive effect of complexity on abundance. As macroinvertebrate length was not associated with fractal dimension, such differences could not be attributed to a higher space available for smaller invertebrates in complex plants. Finally, neither macroinvertebrate density nor size were reduced by fish predation in the Las Flores stream.","palabras_clave":"COMPLEXITY|FRACTAL DIMENSION|DENSITY|SIZE SPECTRA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39354,"idioma_id":4,"titulo":"Spreading of hepatitis C virus subtypes 1a and 1b through the central region of Argentina","resumen":"p { margin-bottom: 0.21cm; direction: ltr; color: rgb(0, 0, 10); line-height: 150%; }p.western { font-family: 'Liberation Sans','Arial',sans-serif; font-size: 11pt; }p.cjk { font-family: '&amp;amp;#23435;&amp;amp;#20307;','SimSun'; font-size: 11pt; }p.ctl { font-family: 'Arial',sans-serif; font-size: 10pt; }a.western:link {  }a.ctl:link {  }      The recent history of the Hepatitis C  Virus (HCV) subtypes 1a and 1b in the central region of Argentina is  hypothesized by phylogeographic reconstruction using coalescent based  Bayesian analyses. Direct partial E2 sequences from HCV 1a and 1b  infected patients attending different health-care centers of the  country were analyzed.    The inferred date of the most recent  common ancestor (tMRCA) for HCV-1a was: 1962 (between 1943  and 1977) and for HCV-1b was earlier: 1929 (between 1895 and 1953).  Diverse ancestral populations were inferred from both subtypes in  Córdoba and in Buenos Aires cities and after that, HCV spread within  and between larger cities and to other smaller cities. The analyses  suggested that HCV-1b was dispersed first and it is currently in a  stationary phase whereas HCV-1a was dispersed latter and it is still  in a growth phase.    Finally, as it was observed in the  developed countries, while the transmission of HCV-1b appears to have  been somehow prevented, the HCV-1a may still represent a concern in  the public health. Further work should be carried out to address  their current transmission rate (and its main transmission route) in  the Argentinean population","palabras_clave":"Hepatitis C 1a|Hepatitis C 1b |epidemiologia|evolucion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39355,"idioma_id":4,"titulo":"Fight or flight: agonistic interactions between females of Acanthogonatus centralis  Goloboff 1995 (Araneae, Mygalomorphae)","resumen":"One hundred and thirty two encounters using a resident (R) ? intruder (I) paradigm between females Acanthogonatus centralis were investigated in order to study its intrasexual interactions and aggressiveness. Also, we examined the effect of presumed increased hunger levels on the incidence of killing and cannibalism. We selected three groups with different satiation levels: medium group (M), low group (L) and high group (H). Interactions took place in 79.54% of the trials. Aggression by lunges or bites was observed in 21.96% of encounters. Spiders made foreleg vibration and touched the silk functioning as aggression-attenuating mechanism. Other general behaviors observed comprehend threat behavior and hug behavior. We found significant differences between charges and retreats in the following treatments: M(R) - M(I), L(R) - L(I), H(R) - H(I) and H(R) - M(I). During encounters we observed 9 cases of cannibalism between females. Interactions are predominantly non-aggressive, at least in the resident-intruder paradigm. Intraspecific predation was not a response to presumed increased hunger. Future approaches of agonistic behavior and cannibalism should include analyses of diet characteristics during more extended time and of experience in determining the outcome of encounters between adult females.","palabras_clave":"MIGALOMORPH SPIDER|NEMESIIDAE|AGONISTIC BEHAVIOR|FEMALE-FEMALE INTERACTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39356,"idioma_id":5,"titulo":"La comunidad de arañas Mygalomorphae (Araneae) de la Reserva Natural Sierra del Tigre (Tandilia, Buenos Aires, Argentina)","resumen":"En el presente trabajo se analizó la riqueza específica, abundancia y actividad de la comunidad de arañas Mygalomorphae en la Reserva Natural ?Sierra del Tigre? (Buenos Aires, Argentina). Este ecosistema serrano alberga numerosas especies endémicas y es rico en fauna y flora nativa. La abundancia de arañas se muestreó mensualmente desde Mayo 2011 ? Mayo 2012 mediante recolección manual y trampas de caída. Las especies registradas en el área de estudio fueron Actinopus sp.1 (Actinopodidae), Grammostola vachoni Schiapelli & Gerschman, 1960; Plesiopelma longisternale Schiapelli & Gerschman, 1942 y Catumiri argentinense (Mello-Leitão, 1941) (Theraphosidae). Grammostola vachoni resultó la especie dominante en la recolección manual y Actinopus sp.1 en trampas de caída. Se discuten y analizan la variación estacional, diversidad y abundancia de la comunidad de migalomorfas. Las Mygalomorphae del sistema de Tandilia comprenden un grupo importante de arañas sedentarias y criptozoicas que parecen depender del tipo de ambiente y factores ambientales.","palabras_clave":"ARAÑAS|ECOLOGÍA|FENOLOGÍA|DIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39357,"idioma_id":4,"titulo":"ARTHROPOD FAUNA OF WINTER WHEAT OF SOUTHWEST BUENOS AIRES PROVINCE, ARGENTINA","resumen":"Agroecosystems are populated by a great diversity and number of invertebrates that are often disturbed by agricultural practices and grazing. The arthropods are good indicators of the heterogeneity of the habitat, the biodiversity of the ecosystem and the stress conditions of the environment, therefore its use for environmental management can reduce pest invasion. The goals of this study are to describe the composition of the arthropod fauna and to analyze how this fauna are distributed throughout the phenological development in a crop of winter wheat at southwestern Buenos Aires Province. Two sampling methods were conducted: at ground level by using pit-fall traps and herbaceous level using a garden-vacuum. A total of 29608 arthropods were collected belonging to 19 orders. The most abundant order was Diptera, followed by Hemiptera, Collembola, Hymenoptera, Acarii, Coleoptera and Araneae. The abundance of the arthropod community associated with the crop increased in the last phenological stages of it. This study comprises one of the first approaches involving the study of the arthropod fauna associated with a winter wheat crop at southwestern Buenos Aires Province, and also is one of the few contributions about this topic in Argentina.","palabras_clave":"COMPOSITION|ABUNDANCE|CEREAL CROP|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39358,"idioma_id":4,"titulo":"A contribution to the knowledge of burrows and reproductive biology of Stenoterommata platensis Holmberg (Mygalomorphae: Nemesiidae)","resumen":"Stenoterommata platensis is a medium-sized nemesiid spider that lives in open burrows. The biology of the Nemesiidae is almost unknown. We describe the courtship and mating of S. platensis for the first time based on two observed matings and add some notes about their burrows in the wild on Martín García Island, Argentina. All males initiated courtship by beating with the first pair of legs when contacted with the female silk from the entrance of the burrow. The copulation position achieved was similar to that of most mygalomorphs. This work constitutes preliminary observations and more data are needed to a better understanding of the reproductive biology of this species.","palabras_clave":"COURTSHIP AND MATING|NATURAL HISTORY|SPIDER|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39359,"idioma_id":4,"titulo":"Removal of humic acid by organo-montmorillonites: Influence of surfactant loading and chain length of alkylamonium cations","resumen":"In this study, the characterization and adsorptionproperties of montmorillonite (MMT) andorganomontmorillonites with different surfactant\/cationic exchange capacity (CEC) ratios (1 and 2) oftetradecyl trimethylammonium (TDTMA+) andhexadecyl trimethylammonium (HDTMA+) cations wereevaluated. The particle apparent diameter, determined bylaser and scanning electron microscopy showed aggregateformation, which varied with loading and cationlength of the surfactant used. X-ray diffraction analysisrevealed the formation of a pseudotrilayer arrangement ofboth surfactants in the interlayer space, FTIR showed thecharacteristic bands of the surfactants and micelle formations,and zeta potential determinations indicated neutralor negative surface charge values, except for sampleobtained with one CEC concentration exchanged withHDTMA+ (HDTMA1-MMT) where a charge reversal topositive was found. Higher adsorption amounts of humicacid (HA) were found for HDTMA1-MMT andTDTMA1-MMT samples than for MMT sample, whilethe increase in the loading of both surfactants decreasedthe amounts of HA adsorbed could be assigned to ahigher micelle formation and different packing densityof alkyl chain, in the external surface. The correlationfound between the total surface area and negative zetapotential values and the HA adsorption rate, within eachsurfactant, indicated the strong influence that these propertieshave on HA adsorption.","palabras_clave":"montmorillonite|humic acids"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39360,"idioma_id":5,"titulo":"Redescripción del canto de anuncio de Gastrotheca gracilis Laurent, 1969 (Anura: Hemiphractidae) y primer registro para el Parque Nacional Campo de Los Alisos, Tucumán, Argentina.","resumen":"El objetivo del presente trabajo es redescribir el canto de anuncio de Gastrotheca gracilis y reportar el registro de esta especie en jurisdicción del Parque Nacional Campo de los Alisos, provincia de Tucumán, Argentina","palabras_clave":"CONSERVACIÓN|CANTO DE ANUNCIO|RANA MARSUPIAL|PARQUES NACIONALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39361,"idioma_id":4,"titulo":"uPA-uPAR molecular complex is involved in cell signaling during neuronal migration and neuritogenesis","resumen":"Background: In the development of the Central Nervous System (CNS), neuronal migrationand neuritogenesis are crucial processes for establishing functional neural circuits. This relies onthe regulation exerted by several signaling molecules, which play important roles in axonal growthand guidance. The urokinase-type plasminogen activator (uPA), in association with its receptor,triggers extracellular matrix proteolysis and other cellular processes through the activation ofsignaling pathways. The uPA:uPAR complex is well characterized in non-neuronal systems, eventhough little is known about its signaling role during CNS development.Results: In response to uPA, neuronal migration and neuritogenesis are promoted in a dosedependentmanner. After stimulation, uPAR interacts with &#945;5- and &#946;1-integrin subunits, which mayconstitute an &#945;&#946;-heterodimer that acts as a co-receptor of the uPA:uPAR complex, favoring theactivation of multiple kinases. This interaction may be responsible for the uPA-promotedphosphorylation of focal adhesion kinase (FAK) and its relocation towards growth cones, triggeringa cytoskeletal reorganization which, in turn, induces morphological changes related to neuronalmigration and neuritogenesis.Conclusions: uPA has a key role during CNS development. In association with its receptor, itorchestrates both proteolytic and non-proteolytic events that govern the proper formation ofneural","palabras_clave":"uPA:uPAR|neuronal migration|neuritogenesis|axonal growth"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39362,"idioma_id":4,"titulo":"First-principles study of point defects in thorium carbide","resumen":"Thorium-based materials are currently being investigated in relation with their potential utilization in Generation-IV reactors as nuclear fuels. One of the most important issues to be studied is their behavior under irradiation. A first approach to this goal is the study of point defects. By means of first-principles calculations within the framework of density functional theory, we study the stability and formation energies of vacancies, interstitials and Frenkel pairs in thorium carbide. We find that C isolated vacancies are the most likely defects, while C interstitials are energetically favored as compared to Th ones. These kind of results for ThC, to the best authors? knowledge, have not been obtained previously, neither experimentally, nor theoretically. For this reason, we compare with results on other compounds with the same NaCl-type structure.","palabras_clave":"First|Principles|thorium |carbide"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39363,"idioma_id":4,"titulo":"Diphenyl diselenide administration enhances cortical mitochondrial number and activity by increasing hemeoxygenase type 1 content in a methylmercury-induced neurotoxicity mouse model","resumen":"Interest in biochemistry of organo selenium compound has increased in the last decades, mainly due to their chemical and biological activities. Here, we investigated the protective effect of diphenyl diselenide (PhSe)2 (5 ìmol\/kg), in a mouse model of methylmercury (MeHg)-induced brain toxicity. Swiss male mice were divided into four experimental groups: control, (PhSe)2 (5ìmol\/kg, subcutaneous administration), MeHg (40 mg\/L, in tap water) and MeHg + (PhSe)2. After the treatment (21 days), the animals were killed and the cerebral cortex analyzed. Electron microscopy indicated enlarged and fused mitochondria leading to a reduced number of organelles, in the MeHg-exposed mice. Furthermore, cortical creatine kinase activity, a sensitive mitochondrial oxidative stress sensor, was almost abolished by MeHg. Subcutaneous (PhSe)2 co-treatment rescued from MeHg-induced mitochondrial alterations. (PhSe)2 also behaved as an enhancer of mitochondrial biogenesis, by increasing cortical mitochondria content in mouse-receiving (PhSe)2 alone. Mechanistically, (PhSe)2 (1 ìM; 24 h) would trigger the cytoprotective Nrf-2 pathway for activating target genes, since astroglial cells exposed to the chalcogen showed increased content of hemeoxygenase type 1, a sensitive marker of the activation of this via. Thus, it is proposed the (PhSe)2-neuroprotective effect might be linked to its mitoprotective activity.","palabras_clave":"DIPHENYL DISELENIDE |MITOCHONDRIA|HEMEOXYGENASE TYPE 1|ELECTRON MICROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39364,"idioma_id":4,"titulo":"Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis and organ growth","resumen":"Genome sequences predict the presence of many 2-oxoglutarate   (2OG)-dependent oxygenases of unknown biochemical and biological   functions in Drosophila. Ribosomal protein hydroxylation is   emerging as an important 2OG oxygenase catalyzed pathway, but its   biological functions are unclear. We report investigations on the   function of Sudestada1 (Sud1), a Drosophila ribosomal   oxygenase. As with its human and yeast homologs, OGFOD1 and Tpa1p,   respectively, we identified Sud1 to catalyze prolyl-hydroxylation of the   small ribosomal subunit protein RPS23. Like OGFOD1, Sud1 catalyzes a   single prolyl-hydroxylation of RPS23 in contrast to yeast Tpa1p, where   Pro-64 dihydroxylation is observed. RNAi-mediated Sud1 knockdown hinders   normal growth in different Drosophila tissues. Growth   impairment originates from both reduction of cell size and diminution of   the number of cells and correlates with impaired translation efficiency   and activation of the unfolded protein response in the endoplasmic   reticulum. This is accompanied by phosphorylation of eIF2á and   concomitant formation of stress granules, as well as promotion of   autophagy and apoptosis. These observations, together with those on   enzyme homologs described in the companion articles, reveal conserved   biochemical and biological roles for a widely distributed ribosomal   oxygenase.","palabras_clave":"DROSOPHILA|GRANULO DE ESTR&#201;S|RIBOSOMA|TRADUCCION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39365,"idioma_id":4,"titulo":"The Drosophila insulin degrading enzyme restricts growth by modulating the PI3K pathway in a cell autonomous manner.","resumen":"Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of growth and metabolism. We find that either loss or gain of function of Drosophila IDE (dIDE) can restrict growth in a cell-autonomous manner by affecting both cell size and cell number. dIDE can modulate Drosophila insulin-like peptide 2 levels, thereby restricting activation of the phosphatidylinositol-3-phosphate kinase pathway and promoting activation of Drosophila forkhead box, subgroup O transcription factor. Larvae reared in high sucrose exhibit delayed developmental timing due to insulin resistance. We find that dIDE loss of function exacerbates this phenotype and that mutants display increased levels of circulating sugar, along with augmented expression of a lipid biosynthesis marker. We propose that dIDE is a modulator of insulin signaling and that its loss of function favors insulin resistance, a hallmark of diabetes mellitus type II.","palabras_clave":"Insulin-degrading enzyme|Growth|Insulin signaling|PI3K|FOXO|Insulin resistance|Drosophila"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39366,"idioma_id":4,"titulo":"Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes","resumen":"Because the ratio between the two major arsenic metabolites is related to the adverse health effects of arsenic, numerous studies have been performed to establish a relationship between the ability to metabolically detoxify arsenic and other variables, including exposure level, gender, age and ethnicity. Because ethnicity may play a key role and provide relevant information for heterogeneous populations, we characterized a group of 70 children from rural schools in the Argentinean provinces of Chaco and Santiago del Estero who were exposed to high levels of arsenic. We used genetic markers for maternal, paternal and bi-parental ancestry to achieve this goal. Our results demonstrate that the Amerindian maternal linages are present in 100% of the samples, whereas the Amerindian component transmitted through the paternal line is less than 10%. Informative markers for autosomal ancestry show a predominantly European ancestry, in which 37% of the samples contained between 90 and 99% European ancestry. The native American component ranged from 50 to 80% in 15.7% of the samples, and in all but four samples, the African component was less than 10%. Correlation analysis demonstrated that the ethnicity and the ratio of the excreted arsenic metabolites monomethyl arsenic and dimethyl arsenic are not associated, dismissing a relationship between ethnic origin and differential metabolism. ","palabras_clave":"ARSENIC|GENETIC|ETHNIC|CHILDREN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39367,"idioma_id":4,"titulo":"Seasonal evaluations of urinary androgen metabolites and semen quality in domestic long tailed chinchilla (Chinchilla lanigera) under natural photoperiod.","resumen":"Chinchilla spp. is a South American hystricomorph rodent genus currently considered almost extinct in the wild. The high quality of chinchilla fur motivated the harvesting of chinchillas for the fur market. Reproductive biology advances come from studies on commercially exploited animals, especially Chinchilla lanigera. We studied seasonal variation of urinary androgen metabolites, sperm concentration and sperm functional activity in males of domestic Chinchilla lanigera under natural photoperiod. In Córdoba city (31° S ? 64° W; Argentina), within the same latitudes as those of the historic Andean distribution (tropical deserts; 15°-34°S), domestic males (n=7) were studied in May (autumn), August (winter), November (spring), and February (summer). Urine was seasonally collected (over 24h; once for season, 4 in total) to measure urinary androgen metabolites (RIA), before semen collection by electroejaculation. The results indicated that although testicular volume (relative to body weight) and&nbsp; values of sperm functional&nbsp; activity did not show seasonal changes, a seasonal variation in androgen excretion was detected, with the highest values occurring during&nbsp; ?short? light\/dark cycles (autumn-winter). In addition, viable spermatozoa with intact acrosome mean values during winter-spring were higher than in autumn or summer. This study provides information that might contribute to the assessment of testicular activity in male chinchilla subjected to genetic selection in the fur industry. In addition, since domestic chinchilla still share some genomic characteristics with their counterparts in the wild, results presented may also contributed to ex situ breeding program of endangered chinchilla. In conclusion, natural photoperiod cycle affects testicular activity in domestic chinchilla.                   ","palabras_clave":"CHINCHILLA|TESTOSTERONE|SPERM|PHOTOPERIOD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39368,"idioma_id":4,"titulo":"Carry-over effects of predation risk on postembryonic life history stages in a freshwater shrimp.","resumen":"For organisms with complex life histories it is well known that risk experienced early in life, as embryosor larvae, may have effects throughout the life cycle. Although carryover effects have been well docu-mented in invertebrates with different levels of parental care, there are few examples of predator-inducedresponses in externally brooded embryos. Here, we studied the effects of nonlethal predation riskthroughout the embryonic development of newly spawned eggs carried by female shrimp on the timingof egg hatching, hatchling morphology, larval development and juvenile morphology. We also deter-mined maternal body mass at the end of the embryonic period. Exposure to predation risk cues duringembryonic development led to larger larvae which also had longer rostra but reached the juvenile stagesooner, at a smaller size and with shorter rostra. There was no difference in hatching timing, but changesin larval morphology and developmental timing showed that the embryos had perceived waterbornesubstances indicative of predation risk. In addition to carryover effects on larval and juvenile stages, pre-dation threat provoked a decrease of body mass in mothers exposed to predator cues while brooding. Ourresults suggest that risk-exposed embryos were able to recognize the same infochemicals as their moth-ers, manifesting a response in the free-living larval stage. Thus, future studies assessing anti-predatorphenotypes should include embryonic development, which seems to determine the morphology anddevelopmental time of subsequent life-history stages according to perceived environmental conditions.","palabras_clave":"COMPLEX LIFE CYCLES|CRUSTACEANS|EXTERNALLY BROODED EGGS|PREDATION RISK|PALAEMONETES ARGENTINUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39369,"idioma_id":4,"titulo":"Ontogeny of consummatory successive negative contrast in rats","resumen":"Consummatory successive negative contrast (cSNC) occurs when organisms repeatedly exposed to a high-magnitude reward are suddenly given a low-magnitude reward. This results in a significant reduction in the consumption of the devalued reinforcer, at a level even below that of a group which had been always exposed to the low-magnitude reinforcer. A scarcity of animal studies assessed the expression of this phenomenon during early development. Three experiments assessed age of cSNC onset in preweanling rats. Percent body weight gained (%BWG) and taste reactions associated with reinforcement devaluation were measured. A reduction in %BWG and a significant increase in emission of aversive hedonic behaviors, indicative of cSNC, occurred on postnatal day 18 (PD 18; Experiments 1 and 2), but not on PD 14 or PD 17 (Experiments 3a and 3b). The neurobiological mechanisms underlying these effects and theoretical implications are discussed.","palabras_clave":"ontogeny|consummatory contrast|disgust|rat"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39370,"idioma_id":4,"titulo":"Optimization of l accase production by two strains of Ganoderma  lucidum using phenolic and metallic inducers","resumen":"Ganoderma lucidum (Curtis) P. Karst is a white rot fungus that is able to degrade the  lignin component in wood. The ability of two strains of this species to produce the  ligninolytic enzyme laccase was assessed. After the evaluation of induction with heavy  metals and phenolic compounds, it was found that among the tested substances, copper  and ferulic acid are the best laccase inducers. It was also observed that the two types of  inducers (phenolic and metallic) produce different electrophoretic patterns of laccase  activity. Optimized concentrations of inducers were obtained through a factorial design  and the thermal stability of optimized supernatants was studied at a wide range of acidic  pH. We found that the enzyme is more thermostable at higher pH values.","palabras_clave":"Vanilloids |Phenolic |Laccase|Copper"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39371,"idioma_id":4,"titulo":"New toxodontid (Notoungulata) from the Early Miocene of Mendoza, Argentina","resumen":"We describe a new toxodontid species, Nesodon taweretus sp. nov., from the Aisol Formation in Mendoza Province, central-west Argentina. Nesodon is a frequently found Toxodontidae, member of the Notoungulata, an extinct endemic group of Cenozoic South American mammals that are ecologically similar to current hoofed ungulates. The holotype of N. taweretus sp. nov. is a skull, and we tentatively assign some mandibular fragments and postcranial bones. N. taweretus sp. nov. differs from the other Nesodon species in several cranial and dental features, and close comparisons were made with the Patagonian Nesodon imbricatus, common in the Santa Cruz Formation (Santacrucian Age, Early Miocene). The material is of a similar size to N. imbricatus, with a body mass estimation of about 550 kg. The phylogenetic analysis groups N. taweretus sp. nov. with other species of Nesodon. The absolute age of the Aisol Formation has been established at ca 19.480 ± 0.025 Ma (Burdigalian; Early Miocene) by means of U?Pb zircon dating. The vertebrate association is encompassed by the Santacrucian Age. Latitudinal separation between Mendoza and Patagonia in the south would have favored taxonomic differences, as reflected in the species of Nesodon.","palabras_clave":"NESODON|SOUTH AMERICA|CENOZOIC|EARLY MIOCENE|U-PB (CA-ID-YIMS) TUFF AGE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39372,"idioma_id":4,"titulo":"Statistical repulsion\/attraction of electrons in graphene  in a magnetic field","resumen":"The aim of this work is to describe the thermodynamic properties of an electron gas in graphene placed in a constant magnetic field. The electron gas is constituted by N Bloch electrons in the long wavelength approximation. The partition function is analyzed in terms of a perturbation expansion of the dimensionless constant ((eB)^(1\/2)*L)^(-1). The statistical repulsion\/attraction potential for electrons in graphene is obtained in the respective case in which antisymmetric\/symmetric states in the coordinates are chosen. Thermodynamic functions are computed for different orders in the perturbation expansion and the different contributions are compared for symmetric and antisymmetric states, showing remarkable differences between them due to the spin exchange correlation. A detailed analysis of the statistical potential is done, showing that, although electrons satisfy Fermi statistics, attractive potential at some interparticle distances can be found.","palabras_clave":"graphene|statistical repulsion\/attraction|magnetic field|partition function"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39373,"idioma_id":4,"titulo":"Generalized contexts and consistent histories in quantum mechanics","resumen":"We analyze a restriction of the theory of consistent histories byimposing that a valid description of a physical system must includequantum histories which satisfy the consistency conditions for allstates. We prove that these conditions are equivalent to imposingthe compatibility conditions of our formalism of generalizedcontexts. Moreover, we show that the theory of consistent historieswith the consistency conditions for all states and the formalismof generalized context are equally useful representing expressionswhich involve properties at different times.","palabras_clave":"Quantum history|Consistent history|Generalized context"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39374,"idioma_id":4,"titulo":"On the nature of defects in liquid-phase exfoliated graphene","resumen":"Liquid-phase exfoliation is one of the most promising routes for large-scale production of multilayer graphene dispersions. These  dispersions, which may be used in coatings, composites, or paints, are  believed to contain disorder-free graphene multilayers. Here, we address the  nature of defects in such samples obtained by liquid-phase exfoliation of graphite powder in N-methyl-2-pyrrolidone. Our Raman spectroscopy data  challenge the assumption that these multilayers are free of bulk defects,  revealing that defect localization strongly depends on the sonication time. For short ultrasound times, defects are located mainly at the layer edges; they turn  out to build up in the bulk for ultrasonic times above 2 h. This knowledge may  help to devise better strategies to achieve high-quality graphene dispersions.","palabras_clave":"Graphene|Liquid-phase exfoliation|Edges defects"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39375,"idioma_id":5,"titulo":"Los relatos policiales de Víctor Juan Guillot","resumen":"Resumen: Los relatos policiales de Víctor Juan Guillot han sido hasta aquí completamente ignorados por la crítica literaria y la historiografía del género policial en la Argentina. Sostenemos que en estos relatos de Guillot puede advertirse el pasaje desde un modelo de relato policial ?aquel que sería el fundamental desde fines de la década de 1870 hasta aproximadamente 1930, con claros aspectos folletinescos y vínculos estrechos con la realidad política y social? hacia una narración detectivesca más cercana al modelo de la Edad de Oro del policial en lengua inglesa y más alejado de la vida empírica nacional. Este último tipo de policial se desarrollará con vigor durante las décadas de 1930 y 1940. En este sentido, mostramos en qué medida los relatos policiales de los libros Historias sin importancia (1920) y El alma en el pozo (1925) consuenan con la tradición temprana del género en la Argentina, mientras que los cuentos incluidos en Terror: cuentos rojos y negros (circa 1935) se hallan en sintonía con los policiales de la década de 1930. Asimismo, exhibimos de qué manera las concepciones de Guillot ?expresadas en la poética de sus relatos y también en reflexiones sobre la novela policial? anticipan ya desde 1925 las ideas de Jorge Luis Borges sobre lo policial durante los años 30.    Palabras clave: Víctor Guillot; Novela policial; Literatura argentina; siglo XX; Jorge Luis Borges     Abstract: This paper studies Victor Juan Guillot?s detective stories, hitherto completely ignored by literary criticism and historiography of the detective genre in Argentina. I argue that in these stories it is possible to see the transition from a sort of detective story-one which was clearly predominant from late 1870 to 1930, with melodramatic features and close links with the political and social reality-into a new kind of detective story, one much closer to the English detective story of the Golden Age and further from the empirical national life. This new type of detective tale will unfold in Argentina vigorously during the 1930s and the 1940s. I show that the detective stories included in Historias sin importancia (1920) and El alma en el pozo (1925) are in the same line with the early tradition of the genre in Argentina, while the stories included in Terror: cuentos de crimen y misterio (circa 1935) have mostly the same features as those of the 1930s. I also show how Guillot?s conception of detective story anticipates already in 1925 Jorge Luis Borges?s conception of the genre in the 30s.    Keywords: Víctor Guillot; Detective Novel; 20th Century; Argentine Literature; Jorge Luis Borges","palabras_clave":"Literatura Policial|Víctor Guillot|Novela policial|Literatura argentina|Siglo XX|Jorge Luis Borges Borges|Historia de la literatura policial"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39376,"idioma_id":4,"titulo":"Hearing and loud music exposure in 14-15 years old adolescents","resumen":"Abstract:  Adolescent exposure to loud music has become a social and health problem whose study demands a holistic approach.  The aims of the current study are:  (1) To detect early noise-induced hearing loss among adolescents and establish its relationship with their participation in musical recreational activities and (2) to determine sound immission levels in nightclubs and personal music players (PMPs).  The participants consisted in 172 14-15 years old adolescents from a technical high school. Conventional and extended high frequency audiometry, transient evoked otoacoustic emissions and questionnaire on recreational habits were administered. Hearing threshold levels (HTLs) were classifi ed as: normal (Group 1), slightly shifted (Group 2), and significantly shifted (Group 3). The musical general exposure (MGE), from participation in recreational musical activities, was categorized in low, moderate, and high exposure. The results revealed an increase of HTL in Group 2 compared with Group 1 (P < 0.01), in Group 3 compared with Group 2 (P < 0.05) only in extended high frequency range, in Group 3 compared with Group 1 (P < 0.01). Besides, a decrease in mean global amplitude, reproducibility and in frequencies amplitude in Group 2 compared with Group 1 (P < 0.05) and in Group 3 compared with Group 1 (P < 0.05). A significant difference (P < 0.05) was found in Group 1?s HTL between low and high exposure, showing higher HTL in high exposure. The sound immission measured in nightclubs (107.8-112.2) dBA and PMPs (82.9-104.6) dBA revealed sound levels risky for hearing health according to exposure times. It demonstrates the need to implement preventive and hearing health promoting actions in adolescents.","palabras_clave":"Conservation Program|Adolescents|Hearing |No ocupational noise"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39377,"idioma_id":4,"titulo":"A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques","resumen":"STUDY QUESTION Can administration of a prostaglandin (PG) E2 receptor 2 (PTGER2) antagonist prevent pregnancy in adult female monkeys by                        blocking periovulatory events in the follicle without altering menstrual cyclicity or general health?                                                                                                  SUMMARY ANSWER This is the first study to demonstrate that a PTGER2 antagonist can serve as an effective non-hormonal contraceptive in primates.                                                                                                  WHAT IS KNOWN ALREADY The requirement for PGE2 in ovulation and the release of an oocyte surrounded by expanded cumulus cells (cumulus¨Coocyte expansion;                        C-OE) was established through the generation of PTGS2 and PTGER2 null-mutant mice. A critical role for PGE2 in primate ovulation                        is supported by evidence that intrafollicular injection of indomethacin in rhesus monkeys suppressed follicle rupture, whereas                        co-injection of PGE2 with indomethacin resulted in ovulation.                                                                                                  STUDY DESIGN, SIZE, DURATION First, controlled ovulation protocols were performed in adult, female rhesus monkeys to analyze the mRNA levels for genes                        encoding PGE2 synthesis and signaling components in the naturally selected pre-ovulatory follicle at different times after                        the ovulatory hCG stimulus (0, 12, 24, 36 h pre-ovulation; 36 h post-ovulation, n = 3¨C4\/time point). Second, controlled ovarian stimulation cycles were utilized to obtain multiple cumulus¨Coocyte complexes                        (COCs) from rhesus monkeys to evaluate the role of PGE2 in C-OE in vitro (n = 3¨C4 animals\/treatment; ¡Ý3 COCs\/animal\/treatment). Third, adult cycling female cynomolgus macaques were randomly assigned                        (n = 10\/group) to vehicle (control) or PTGER2 antagonist (BAY06) groups to perform a contraceptive trial. After the first treatment                        cycle, a male of proven fertility was introduced into each group and they remained housed together for the duration of the                        5-month contraceptive trial that was followed by a post-treatment reversibility trial.                                                                                                  PARTICIPANTS\/MATERIALS, SETTING, METHODS Quantitative real-time PCR, COC culture and expansion, immunofluorescence\/confocal microscopy, enzyme immunoassay, contraceptive                        trial, ultrasonography, complete blood counts, serum biochemistry tests and blood lipid profiles.                                                                                                  MAIN RESULTS AND THE ROLE OF CHANCE Several mRNAs encoding proteins involved in PGE2 synthesis, metabolism and signaling increase (P P                                                                             LIMITATIONS, REASONS FOR CAUTION This is a proof-of-concept study in a non-human primate model. Further investigations are warranted to elucidate the mechanism(s)                        of PTGER2 antagonist action in the primate ovary. Although PTGER2 antagonist treatment did not produce any obvious undesirable                        effects, improvements in the mode of administration, as well as the efficacy of these compounds, are necessary to consider                        such a contraceptive for women.                                                                                                  WIDER IMPLICATIONS OF THE FINDINGS Monitoring as well as improving the efficacy and safety of female contraceptives is an important public health activity.                        Even though hormonal contraceptives are effective for women, concerns remain regarding their side-effects and long-term use                        because of the widespread actions of such steroidal products in many tissues. Moreover, some women cannot take hormones for                        medical reasons. Thus, development of non-hormonal contraceptives for women is warranted.                                                                                                  STUDY FUNDING\/COMPETING INTEREST(S) Supported by Bayer HealthCare Pharmaceuticals, The Eunice Kennedy Shriver NICHD Contraceptive Development and Research Center                        (U54 HD055744), NIH Office of the Director (Oregon National Primate Research Center P51 OD011092), and a Lalor Foundation                        Postdoctoral Basic Research Fellowship (MCP). The use of the Leica confocal was supported by grant number S10RR024585. Some                        of the authors (N.B., A.R., K.-H.F., U.F., B.B. and B.L.) are employees of Bayer Healthcare Pharma. ","palabras_clave":"PROSTAGLANDIN E2 RECEPTOR|CUMULUS OOCYTE EXPANSION|CONTRACEPTIVE TRIAL|PRIMATES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39378,"idioma_id":4,"titulo":"New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia","resumen":"Previous studies have revealed the association between SNPs located on human leukocyte antigen (HLA) class II genes, including HLA-DP and HLA-DQ, and chronic hepatitis B virus (HBV) infection, mainly in Asian populations. HLA-DP alleles or haplotypes associated with chronic HBV infection or disease progression have not been fully identified in Asian populations. We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. To assess the association between HLA-DP and chronic HBV infection and disease progression, we conducted high-resolution (4-digit) HLA-DPA1 and HLA-DPB1 genotyping in a total of 3,167 samples, including HBV patients, HBV-resolved individuals and healthy controls. Trans-ethnic association analyses among Asian populations identified a new risk allele HLA-DPB1*09 ¡Ã 01 (P = 1.36 ¡Á 10(-6); OR= 1.97; 95% CI, 1.50-2.59) and a new protective allele DPB1*02 ¡Ã 01 (P = 5.22 ¡Á 10(-6); OR = 0.68; 95% CI, 0.58-0.81) to chronic HBV infection, in addition to the previously reported alleles. Moreover, DPB1*02 ¡Ã 01 was also associated with a decreased risk of disease progression in chronic HBV patients among Asian populations (P = 1.55 ¡Á 10(-7); OR = 0.50; 95% CI, 0.39-0.65). Trans-ethnic association analyses identified Asian-specific associations of HLA-DP alleles and haplotypes with HBV infection or disease progression. The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.","palabras_clave":"HBV|HLA|ASIAN ETHNICITY|SNP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39379,"idioma_id":4,"titulo":"Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats","resumen":"It is yet unclear if ethanol-induced motor stimulation in the open field (OF) merely reflects psychomotor stimulating effects of the drug or if this stimulation is driven or modulated by ethanol´s antianxiety properties. In the present study, adolescent rats were administered with different ethanol doses or remained untreated. They were sequentially assessed in the OF, elevated plus maze (EPM), and light-dark box (LDB) and then assessed for ethanol intake. The aims were to assess the relationship between measures of ethanol-induced activity and anxiolysis, analyze ethanol intake as a function of prior ethanol exposure, and associate behavioral responsiveness in these apparatus with ethanol intake during adolescence. The results suggested that the enhanced exploration of the OF observed after 2.5 and 3.25 g\/kg ethanol reflected a motor-stimulating effect that appeared to be relatively independent of anxiolysis. The 1.25 g\/kg dose induced motor stimulation in the OF and anti-anxiety effects in the EPM, but these effects were relatively independent. The 0.5 g\/kg ethanol dose exerted significant anxiolytic effects in the EPM in the absence of stimulating effects in the OF. A multivariate regression analysis indicated that adolescents with a higher frequency of rearing behavior in the OF, higher percentage of open arm entries in the EPM, and lower propensity to enter the central area of the OF exhibited greater ethanol intake. These results indicate that the OF is a valid procedure for the measurement of ethanol-induced stimulation, and provide information toward characterizing subpopulations of adolescents at risk for initiating alcohol drinking.","palabras_clave":"ANXIETY|ELEVATED PLUS MAZE|ETHANOL INTAKE|LIGHT DARK BOX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39380,"idioma_id":4,"titulo":"Biological and molecular characterization of an isolate of Pelargonium zonate spot virus infecting sunflower in Argentina","resumen":"Sunflower (Helianthus annuus) plants showing chlorotic concentric rings and line patterns on the leaves were observed in field crops near Paraná city (Entre Ríos, Argentina). Virus-enriched preparations examined with a  trasmission electron microscope contained quasi-spherical particles ca. 33 nm in diameter. Symptomatic sunflower samples were serologically negative for six known members of the family Bromoviridae when tested with commercial antisera, but in later tests gave a positive reaction  with a Pelargonium zonate spot virus (PZSV) antiserum. The virus was mechanically transmitted to 16 plant species belonging to four families. Its complete genomic sequence, obtained by pyrosequencing, had an organization typical of members of the family Bromoviridae. Three contigs resulting from de novo assembly of deep sequencing reads showed 90.0%, 94.7% and 93.9% nucleotide identity with RNA-1 (GenBank accession No. AJ272327), RNA-2 (AJ272328) and RNA-3 (AJ272329), respectively, of Pelargonium zonate spot virus (PZSV), a member of the genus Anulavirus described in Italy. Therefore, the virus associated with chlorotic concentric rings and line pattern symptoms in sunflower was identified as an isolate of PZSV. To our knowledge, this is the first reference to PZSV infecting sunflower worldwide and the first report of its presence in South America.","palabras_clave":"PZSV |SUNFLOWER|BROMOVIRIDAE|CHLOROTIC CONCENTRIC RINGS, LINE PATTERN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39381,"idioma_id":4,"titulo":"Complete nucleotide sequence of Alfalfa mosaic virus isolated from alfalfa (Medicago sativa L.) in Argentina","resumen":"The complete nucleotide sequence of an Alfalfa mosaic virus (AMV) isolate infecting alfalfa (Medicago sativa L.) in Argentina, AMV-Arg, was determined. The virus genome has the typical organization described for AMV, and comprises 3,643, 2,593, and 2,038 nucleotides for RNA1, 2 and 3, respectively. The whole genome sequence and each encoding region were compared with those of other four isolates that have been completely sequenced from China, Italy, Spain and USA. The nucleotide identity percentages ranged from 95.9 to 99.1 % for the three RNAs and from 93.7 to 99 % for the protein 1 (P1), protein 2 (P2), movement protein and coat protein (CP) encoding regions, whereas the amino acid identity percentages of these proteins ranged from 93.4 to 99.5 %, the lowest value corresponding to P2. CP sequences of AMV-Arg were compared with those of other 25 available isolates, and the phylogenetic analysis based on the CP gene was carried out. The highest percentage of nucleotide sequence identity of the CP gene was 98.3 % with a Chinese isolate and 98.6 % at the amino acid level with four isolates, two from Italy, one from Brazil and the remaining one from China. The phylogenetic analysis showed that AMV-Arg is closely related to subgroup I of AMV isolates. To our knowledge, this is the first report of a complete nucleotide sequence of AMV from South America and the first worldwide report of complete nucleotide sequence of AMV isolated from alfalfa as natural host.","palabras_clave":"Alfalfa mosaic virus|Complete genome|Phylogenetic relationships|Alfalfa"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39382,"idioma_id":4,"titulo":"Effect of gregarines (Apicomplexa: Sporozoa) on survival and weight loss of Victorwithius similis Beier, 1959 (Arachnida: Pseudoscorpiones)","resumen":"Gregarines are common intestinal parasites of numerous invertebrate groups. Their effects on hostviability and development have been a matter of debate. Although they may not be lethal to the host,they can be harmless commensals, by affecting adaptive traits, or have a beneficial relationship withthe host. This study focused on determining prevalence, intensity, and change in infection intensity overtime by septate gregarines, and monitoring the effects on survival and weight loss in the pseudoscorpionVictorwithius similis. Individuals (n = 24 females, n = 55 males and n = 41 tritonymphs) were captured inthe field, transported to the vivarium and bred under laboratory conditions. A high prevalence of infectionwas found, with 77.27% of females, 62.50% of males and 73.53% of tritonymphs harboring intenseinfections. Of the infected pseudoscorpions, 62% of females, 58% of males and 71% of tritonymphs didnot show changes in infection intensity over time. The group that maintained intense infections survivedlonger than those with less intense infections (v2 = 8.642; p = 0.035). Most of the results obtained indicatethat relationship studied between gregarines and the pseudoscorpion V. similis might be a case ofcommensalism. This would explain why the infection level and prevalence was very high, as well asthe apparent lack of direct costs to highly infected individuals those with infections.","palabras_clave":"Gregarines  |Survival|Weight loss|Pseudoscorpions"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39383,"idioma_id":4,"titulo":"Theoretical kinetic study of the unimolecular decomposition of 2-bromopropene","resumen":"The kinetics of the gas phase thermal decomposition of 2-bromopropene at 600-1400 K has beenstudied by using the unimolecular rate theory combined with different formulations of the densityfunctional theory and high level ab initio composite methods. This hydrogen bromide eliminationreaction presents two dissociation channels, one forming propyne and another forming allene. Highpressure limit rate coefficients of (6.2 ± 1.2) x 1014 exp [-(64.5 ± 2 kcal mol-1)\/RT] and (1.1 ± 0.1) x 1014 exp [-(63.6 ± 2 kcal mol-1)\/RT] s-1 were obtained for these reaction pathways. The present results allow to elucidate reported contradictory experimental data.","palabras_clave":"2-BROMOPROPENE |UNIMOLECULAR DECOMPOSITION|KINETICS|QUANTUM-CHEMICAL CALCULATIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39384,"idioma_id":4,"titulo":"Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A","resumen":"Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.","palabras_clave":"MOTORES MOLECULARES|SIMULACIÓN MONTE CARLO|PROCESOS ESTOCÁSTICOS|PROTEÍNAS ASOCIADAS AL MICROTÚBULO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39385,"idioma_id":4,"titulo":"Puyehue Cordón ?Caulle: post-eruption analysis of changes in stream benthic fauna of Patagonia","resumen":"Volcanic eruptions are natural phenomena with the most diverse and varied consequences, andhave important effects on both terrestrial and aquatic environments. On June 4th, 2011 the volcanic Puyehue Cordón-Caulle complex (2.236 masl, 40º 32´ S-72º 2´ W, Chile) erupted explosively ejecting on the first day, 950 million metric tons of ashes into the atmosphere. Due to predominant westerly winds, 24 million hectares of Argentinian Patagonia were covered by the ashfall. We studied three streams in northwestern Patagonia in order to explore the ash fall impact and possible recovery processes in water quality and macroinvertebrate communities. We selected three streams representing maximum, intermediate and minimum ash deposition levels. For each stream, we selected two sampling sites to measure pH, conductivity, total dissolved solids (TDS), turbidity (NTU) and to take three macroinvertebrate samples during summer 2012 and 2013. After the eruption of the Puyehue-Cordón Caulle complex, substantial environmental changes were observed in association with the large amount of ash ejected by the volcano and deposited on the nearest areas. Low benthic fauna densities, as well as low values of Ephemeroptera, Plecoptera and Trichoptera (EPT) and Biotic Monitoring Patagonian Streams (BMPS) indexes, reflected changes in water quality due to ash fall, mainly in the two streams closer to the volcano. After eighteen months, the streams had not reached the density, taxa composition and structure of trophic webs comparable to other streams previously studied in the region. The exploratory analysis suggests that the main impact was a consequence of ash fall in terms of the amount andparticle size proportions. ","palabras_clave":"ERUPCION VOLCANICA|IMPACTOS |BENTOS |ARROYOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39386,"idioma_id":5,"titulo":"Evo-devo como disciplina integradora: la temporalidad de los procesos biológicos como estrategia de análisis","resumen":"El objetivo del presente trabajo es indagar en la naturaleza integradora de la biología evolutiva del desarrollo (evo-devo). En particular, analizamos las características temporales de los procesos estudiados por diferentes programas de investigación de evo-devo, y las comparamos con aquellas propias de los procesos macroevolutivos, microevolutivos y del desarrollo de los organismos. Encontramos que en la genética evolutiva del desarrollo se recuperan principalmente características propias de losfenómenos macroevolutivos (planteándose cierta continuidad entre tales fenómenos y los cambios genético-moleculares y organísmicos), mientras que en la sub-área de eco-evo-devo (biología evolutiva ecológica del desarrollo) se recuperan principalmente características propias de la microevolución.","palabras_clave":"DESARROLLO|EVO-DEVO|EVOLUCION|TIEMPO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39387,"idioma_id":4,"titulo":"- Association between spoligotype-VNTR types and virulence of Mycobacterium bovis in cattle","resumen":"Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that affects approximately 5% of Argentine cattle. The aim of this research was to study if it is possible to infer the degree of virulence of different M. bovis genotypes based on scorified observations of tuberculosis lesions in cattle.In this study, we performed association analyses between several parameters with tuberculosis lesions: M. bovis genotype, degree of progression of tuberculosis, and animal age. For this purpose, the genotype was determined by spoligotyping and the degree of bovine tuberculosis gross lesion was quantified with a score based on clinical observations (number, size, and location of granulomas along with histopathologic features). This study was performed with naturally infected cattle of slaughterhouses from three provinces in Argentina.A total of 265 M. bovis isolates were obtained from 378 pathological lesion samples and 192 spoligotyping and VNTR (based on ETR sequences) typing patterns were obtained. SB0140 was the most predominant spoligotype, followed by SB0145. The spoligotype with the highest lesion score was SB0273 (median score of 27 ± 4.46), followed by SB0520 (18 ± 5.8). Furthermore, the most common spoligotype, SB0140, had a median score of 11 ± 0.74. Finally, the spoligotype with the lowest score was SB0145 (8 ± 1.0). ETR typing of SB0140, SB0145, SB0273, and SB0520 did not subdivide the lesion scores in those spoligotypes.In conclusion, SB0273 and SB0520 were the spoligotypes with the strongest association with hypervirulence and both spoligotypes were only found in Río Cuarto at the south of Córdoba province. Interestingly, there is no other report of any of these spoligotyes in Latin America","palabras_clave":"Mycobacterium bovis|VNTR|genotype|spoligotype"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39388,"idioma_id":4,"titulo":"A new non- indigenous Crassostrea species in Southwest Atlantic salt marshes affects mortality of the cordgrass Spartina alterniflora","resumen":"Biological invasions in marine and coastal systems may produce new trophic and nontrophic interactions influencing the structure of the invaded community. In the intertidal salt marshes of Samborombón Bay  (36°19&#8242;20&#8243;S, 56°46&#8242;26&#8243;W; mouth of La Plata River; Argentina), there is a new non-indigenous oyster species, Crassostrea sp., which settles on the dominant smooth cordgrass Spartina alterniflora. Here, we analyzed if the  oyster affects S. alterniflora. Sampling showed that density of live Plant was similar across intertidal levels, but there were higher density of dead plant stems at low intertidal levels. This pattern coincides with higher density and larger shell size of Crassostrea sp. at the low intertidal where oysters are attached to the basal part of the plant stems. An experiment manipulating oysters attached to S. alterniflora stems and oyster mimics shows that Crassostrea sp. can indeed increase mortality of S. alterniflora. The negative effect of bivalves on plant could be because several oysters settle around the Spartina stem, and by growing during the year, strangle the plants increasing their mortality rate. Together, all these evidences strongly suggest that these non-indigenous oysters can control the lower intertidal level of plant distribution in this system.","palabras_clave":"Spartina alterniflora|Non-indigeous Crassastrea sp|Interactions|Samborombón Bay"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39389,"idioma_id":4,"titulo":"Effect of crab bioturbation on organic matter processing in South West Atlantic intertidal sediments","resumen":"Organic matter (OM) remineralization plays a key role controlling the  biogeochemistry of marine sediments. Through their burrowing activities, bioturbating macrofauna not only induces physical, chemical and biological modifications, which can affect microbial communities responsible for organic matter remineralization, but it could  also directly affect the distribution and bioavailability of sedimentary organic matter. Through in situ experiments manipulating crab and burrow density in intertidal softbottoms,we assessed if crab-bioturbation affects benthic metabolism, and the amount,distribution, and bioavailability of sedimentary OM. Crab-bioturbation enhanced overall  benthic metabolism and benthic flux of dissolved OM towards the water column at both mudflat and saltmarsh zones. Moreover, our results revealed that bioturbation also changes the quality, bioavailability and distribution of sedimentary OM in mudflats and saltmarshes. Overall, bioturbation enhanced the proportion of labile organic carbon of bioturbated sediments and homogenized the sediment column in terms of their proportion of labile-organic carbon. However, crabs also generated biogenic structures (e.g., mounds) that could promote spatial heterogeneity of high nutritional-value OM. Bioturbation-induced changes  on benthic metabolism and on OM availability would result in a reduction of the storage capacity of carbon in our intertidal systems. Previous works indicated that crab-burrows trap detritus and OM-rich sediments. Our results suggest that detritus are efficiently remineralized at bioturbated sediment, and finally they are quickly exported to the water  column as CO2 and DOC. Thus, crabs are modifying the OM processing at intertidal soft bottoms, and the ways in which carbon is exported to coastal waters.","palabras_clave":"Bioturbation|Organic matter|Neohelice granulata|intertidal|crab|saltmarshes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39390,"idioma_id":4,"titulo":"Integrated pest management to control Varroa destructor and its implications to Apis mellifera colonies","resumen":"    This article covers  the principal aspects of the interaction between Apis mellifera- Varroa destructor. First of all, it describes the  classical control forms applied to reduce the mite impact on colonies. Several  products along the world have shown good effectiveness. Nevertheless, there  exist certain risks and hazards inherent to their use, such as their negative  impact on human health, loss of benefic insects and native fauna, environmental  pollution, drug residues in products meant for human consumption and resistance  phenomena.    The development of acaricide  resistance in V. detructor populations  and the possibility of incorporating contaminants in colonies by means of this  type of treatment have promoted the addition of new molecules to minimize said  disadvantages. Among them, the application of organic acids, essential oils and  their components have become a worthwhile alternative. However, some  studies have reported undesirable effects of  organic substances when they were applied to A. mellifera colonies, which streeses the need to implement  management strategies  involving much  more than a mere change of one molecule for another.    Integrated Pest Management (IPM) is a pest  management system that, in the socioeconomic context of farming systems, the  associated environment and the population dynamics of the pest species,  utilizes all suitable techniques in as compatible a manner as possible and  maintains the pest population levels below those causing economic injury. In  terms of strategies for pest control, IPM is the most modern concept. This  paper present an example of an IPM carried out for V. destructor in the southeast of Buenos Aires province which  showed good results.  To achieve an integrated management of Varroa destructor entails a change of  mind for beekeepers and the active participation of all those players involved  in the industry. Producers should understand that the only way in which  parasites can be managed is by implementing health strategies that address  parasites and hosts biology, both of which are essential to attain an effective  acaricide treatment. National and private scientific bodies should engage with  the current issues faced by beekeeping and promote scientific activities aimed  at discovering and developing new tools that could be implemented in an IPM.  ","palabras_clave":"Apis mellifera|Varroa destructor|Integrated Pest Management|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39391,"idioma_id":4,"titulo":"Thermodynamic Properties for the Simulation of Crude Oil Primary Refining","resumen":"Commonly, the use of simulators inthe industry is performed without having a proper theoretical support.Sometimes this situation is a consequence of both, lack of time and the dairydynamism required in the refinery industries. Particularly, the application ofthermodynamic models is often not properly considered for the specific processunder analysis. An undesirable fact can appear, for example, when a wrongproperties package is chosen or even more when this selection step iscompletely ignored. The aim of this article is to prove that the habitualselection of the thermodynamic models is appropriate or not for the primaryrefining process. For the purpose, two available simulation softwares and thermodynamicmodels have been analyzed. The research paper focuses on establishing a guidefor plant operators with information that has been previously proven, withtheoretical support. In particular, for the oil crude atmospheric distillation(Topping), engineers use almost by default the Peng? Robinson thermodynamicpackage in Aspen Hysys simulator and Chao?Seader in Aspen Plus. Although theuse of the thermodynamic property packages involves a whole theoreticalsupport, this is not considered at the time of their election.","palabras_clave":"CRUDE OIL|DISTILLATION|SIMULATION|THERMODYNAMIC PROPERTIES|TOPPING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39392,"idioma_id":4,"titulo":"A parametric information-theory model for predictions in time series","resumen":"In this work, a&nbsp; technique based on&nbsp; information theory is developed to make predictions in chaotic time series. Numerical examples are given to illustrate&nbsp; the effectiveness of theproposed method.","palabras_clave":"TIME SERIES|MODEL|PREDICTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39393,"idioma_id":4,"titulo":"Abrogation of TNFa Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12","resumen":"For more than a decade, the cytokine interleukin-12 (IL-12) has been utilized, either alone or in combination with other drugs, as a treatment for cancer. The numerous anti-tumor properties of IL-12 still generate interest in the clinical use of this cytokine, even though it has demonstrated toxicity when administrated systemically. As an approach to overcome thistoxicity, numerous laboratories have attempted to induce IL-12 expression at the site of the tumor. However for tumors that are difficult to remove surgically or for the treatment of disseminated metastases, systemic expression of this cytokine still remains as the most efficient method of administration. Nevertheless, finding alternative approaches for the use of IL-12 in the treatment of cancer and unraveling the basis of IL-12-side effects remain a challenge. In the present work we demonstrate that systemic expression of IL-12 through hydrodynamic injection of IL-12 cDNA is able to induce different types of liver lesions associated with a toxic pathology. However we report here that hepatic toxicity is diminished and survival of mice enhanced in the absence of tumor necrosis factor alpha (TNFa). This observation is in contrast to several murine models and clinical trials that postulate interferon gamma (IFNc) as the main cytokine responsible for IL-12 toxicity.Moreover, our work demonstrates that when IL-12 cDNA is co-injected with IL-18 cDNA or when mice are pre-treated with a low dose of IL-12 cDNA prior to receiving a high dose of IL-12 cDNA, systemic levels of TNFa are almost completely abrogated, resulting in improved survival and less hepatic damage. Importantly, abrogation of TNFa signaling does not affect the strong anti-tumor activity of IL-12. Thus, neutralizing TNFa with antagonists already approved for human use offers a promising approach to abrogate IL-12 side effects during the use of this cytokine for the treatment of cancer.","palabras_clave":"cancer|inmunoterapia|TNFalfa|Interleuquina 12"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39394,"idioma_id":5,"titulo":"Hacia una mirada de género en los estudios de movilidad social: interrogantes teórico-metodológicos","resumen":"El debate sobre la incorporación de la mujer en los estudios de movilidad y estructura social cuenta con antecedentes empíricos en la Argentina (Gómez Rojas, 2009). Si bien son cada más los estudios que tienen en cuenta a las mujeres a la hora de analizar estos temas, todavía no se han generado antecedentes suficientes para construir la movilidad social femenina como objeto de estudio, tal cual lo propusiera Salido Cortés (2001) para España. Este trabajo tiene como objetivo explorar  aspectos dela movilidad social intergeneracional para mujeres y varones. Se pretende aportar conocimientos sobre áreas poco y casi nada exploradas del movimiento de la sociedad argentina.. La fuente de datos utilizada es la Encuesta de Estratificación y Movilidad Social, relevada por el CEDOP-UBA en el 2007. Es una encuesta nacional, probabilística, de 3313 casos. El esquema de clases sociales adoptado es el presentado por Goldthorpe y colaboradores (Goldthorpe, 2010).","palabras_clave":"varones|Movilidad social|mujeres"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39395,"idioma_id":4,"titulo":"Heterogeneous Two-Region Model for Low-Aspect-Ratio Fixed-Bed Catalytic Reactors. Analysis of Fluid-Convective Contributions","resumen":"A two-region, two-dimensional (2R2D) model aimed at improving the heat transfer description of multitubular catalytic reactors is introduced here. The effects concentrated in the wall thermal resistance (1\/hw) of the standard 2D model (S2D model) are distributed in a fluid channel from the wall up to a distance of half-particle diameter and in the particle layer against the wall. The use of computational fluid dynamics (CFD) on regular arrays allowed estimations of two of the 2R2D key parameters: the heat transfer coefficient between wall and core channels hf and the ?true? wall-to-fluid coefficient hwf. The 2R2D and S2D models are compared at conditions when fluid mechanisms dominate radial heat exchange and reversible or irreversible catalytic reactions are carried out. The case of NH3 synthesis was taken as a basis of comparison. Significant differences are obtained in temperature predictions within the usual range of the tube-to-particle diameter ratio, 5 < N < 10, mainly for irreversible kinetics.","palabras_clave":"Fixed-bed reactors|Two-region model|CFD|Convective contributios"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39396,"idioma_id":5,"titulo":"La educación corporal salesiana en la Gobernación Militar de Comodoro Rivadavia, 1944 - 1955","resumen":"En este artículo nos interesa analizar  las formas que fue adquiriendo el discurso corporal de la comunidad educativa salesiana  en el marco de la denominada Gobernación Militar de Comodoro Rivadavia, 1944 ?  1955. Desde mediados de la década del ?30 la congregación salesiana impulsó,  con la colaboración de la Administración de Yacimientos Petrolíferos Fiscales  (YPF), una formación técnica para los jóvenes que posteriormente ingresarían a  la empresa petrolífera estatal. En este escrito mostraremos que con la  instalación de una Escuela de Artes y Oficios en 1937 la Iglesia pretendió  acercar la doctrina cristiana al mundo del trabajo, y con ella un modo de masculinidad.  ","palabras_clave":"EDUCACIÓN|CUERPO|COMUNIDAD SALESIANA|PERONISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39397,"idioma_id":4,"titulo":"The Andean Swallow Oro chelidon andecola in Argentina","resumen":"During ornithological studies in the provinces of Jujuy, Salta, and San Juan, we recorded the Andean Swallow Orochelidon andecola at 40 localities. These are the first records in Argentina, and also represent the southernmost for the species. Some of these localities are up to 1500 m lower than the previously known elevational limit (now 800 masl), and up to 1100 km southwards. This is a relatively poorly known swallow, and we present novel natural history data. We found evidence of breeding in five localities. We obtained photographs and tape recordings, and provide details of a specimen.","palabras_clave":"Orochelidon andecola|distribution|natural history|Seasonal movements"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39398,"idioma_id":4,"titulo":"Characterization of quaternary ammonium compounds in Flourensia xerophytic communities and response to UV-B radiation","resumen":"As part of ongoing studies aimed at characterizing molecular components involved in the ecophysiological adaptations of native xerophytic plants from central Argentina, we demonstrated the presence of compatible solutes in Flourensia campestris (FC) and F. oolepis (FO), and specifically of glycine betaine (GB) through TLC, LC, 1H-NMR and 13C-NMR. GB content (leaves: 38±7 µmol g-1 DW; adult plants>seedlings), and distribution (capitula > vegetative leaves > reproductive leaves > shoots> roots) were similar to other quaternary ammonium compound (QAC) accumulators. Flourensia seedlings from both species protected from UV-B exposure ?a major abiotic stress in these natural environments- showed a significant increase of GB in the leaves (p<0.01) and a significant decrease in the roots (p<0.05). In FC and FO xerophytic shrub-dominated communities QACs were detected for first time in 41% of co-occurring species (N=39), 14 of 28 natives (50%) and 2 of 11 exotics (18%), being GB in natives only (57% of QAC accumulators). GB may be considered as a chemotaxonomical character for the genus Flourensia, since it was also detected in F. hirta, F. niederleinii, F. riparia , F. fiebrigii, F. macroligulata and F. heterolepis. Our controlled UV-B experiments, set up in the same natural environment where these species grow, clearly show that solar UV-B ? and therefore oxidative stress- is involved in regulating GB contents and within-plant distribution in FC and FO seedlings. The findings in Flourensia co-occurring native species suggest that QACs accumulation may be considered as a community-specific ecophysiological trait in these xerophytic environments.","palabras_clave":"quaternary ammonium compounds|Flourensia spp|UV-B radiation|xerophytic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39399,"idioma_id":4,"titulo":"The novel evidence of the specific interaction between cholesterol and a RTX toxin","resumen":"Several toxins that act on animal cells present different, but specific, interactions with cholesterol or sphingomyelin. In the present study we demonstrate that HlyA (&#945;-haemolysin) of Escherichia coli interacts directly with cholesterol. We have recently reported that HlyA became associated with detergent-resistant membranes enriched in cholesterol and sphingomyelin; moreover, toxin oligomerization, and hence haemolytic activity, diminishes in cholesterol-depleted erythrocytes. Considering these results, we studied the insertion process, an essential step in the lytic mechanism, by the monolayer technique, finding that HlyA insertion is favoured in cholesterol- and sphingomyelin-containing membranes. On the basis of this result, we studied the direct interaction with either of the lipids by lipid dot blotting, lysis inhibition and SPR (surface plasmon resonance) assays. The results of the present study demonstrated that an interaction between cholesterol and HlyA exists that seems to favour a conformational state of the protein that allows its correct insertion into the membrane and its further oligomerization to form pores","palabras_clave":"Cholesterol|RTX toxin|SPR|Biacore"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39400,"idioma_id":5,"titulo":"BANCO DE SEMILLAS, GERMINACIÓN Y LONGEVIDAD DE SEMILLAS DE RETAMA (SPARTIUM JUNCEUM, FABACEAE): IMPLICANCIAS PARA SU CONTROL","resumen":"La retama (Spartium junceum) es una especie  invasora de pastizales naturales en las sierras australes bonaerenses. Estudiamos  características del proceso de germinación que podrían resultar clave para su  control. Calculamos la densidad de semillas y el porcentaje de germinación para  muestras de suelo provenientes de tres sectores invadidos. Realizamos ensayos  de germinación en panes de tierra mantenidos a la intemperie y ensayos en  cámara de germinación con semillas colectadas directamente de individuos  adultos y con semillas tomadas del banco del suelo siete años antes del ensayo.  La densidad en el banco del suelo de áreas invadidas varió entre 600 y 4.411  semillas\/m2. El porcentaje de germinación de semillas de ensayos en  panes de tierra fue de 68,33 ±26,66 %.  En el caso de los ensayos en cámara, la escarificación mecánica resultó en la  germinación del total de las semillas recolectadas de las plantas, contra  apenas un 7 ±5,7  % de germinación para el control y valores aún inferiores para shock térmico y  combinación shock térmico + escarificación mecánica El ensayo con semillas de muestras de suelo  (almacenadas durante siete años) resultó en un porcentaje de germinación del  88,73 ±11,16 % para la escarificación mecánica, 85,77 ±10,50 % para shock térmico, 40,30 ±10,14 %  para imbibición y 43,20 ±12,01 % para el control. Altas temperaturas durante  períodos cortos, lesiones en la cubierta seminal y disturbios del suelo  favorecen considerablemente la germinación y estimulan los procesos de  invasión.","palabras_clave":"Invasiones biológicas|Pastizales naturales|Retama|Germinación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39401,"idioma_id":4,"titulo":"Anthropogenic nesting sites allow urban breeding in burrowing parrots Cyanoliseus patagonus","resumen":"How birds adapt tourban life is a key question in evolutionary and conservation biology sinceurbanisation is one of the major causes of habitat loss worldwide. Some speciesare able to deal with these anthropogenic changes but a shortage of nestingsites may preclude them from breeding in cities. We conducted a baseline surveyof the cliff-nesting burrowing parrot Cyanoliseuspatagonus around Bahía Blanca (Argentina), estimating a minimum total of1,361 pairs breeding at 24 sites (colonies) in 2013. The species showedfacultative colonial behaviour, colony size varying between 1 and 300 pairs.Most colonies (68%) and pairs (74%) occupied human-made substrates, mostlyquarries but also water wells. Colony size was strongly correlated to theextent of both natural and anthropogenic nesting substrates, suggesting anideal free distribution of pairs according to the availability of nestingresources. Anthropogenic substrates have certainly allowed population expansionin what is a rather flat landscape with a shortage of cliffs and ravines, aswell as urban breeding by a large part (61%) of the surveyed population. Thisis currently one of the largest populations of burrowing parrots, a previouslyabundant species that is progressively threatened by persecution and nestpoaching for the international pet trade.","palabras_clave":"COLONIALITY |NEST-SITE INNOVATIONS|NEST-SITE SHORTAGE|PSITTACIDAE|QUARRIES AND URBANISATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39402,"idioma_id":4,"titulo":"The influence of feral horses dung piles on surrounding vegetation. Management of Biological Invasions","resumen":"The effect of grazing by large herbivores ongrassland communities has been extensively studied, however less is known aboutchanges associated with sites of high-intensity activity, such as dust bowls,tracks, urine patches and dung piles, that might induce disproportionateimpacts to the directly affected areas and the surrounding vegetation. Thispaper explores the changes associated with exotic feral horse dung piles inrelicts of natural grasslands in Argentine Pampas. We expected greater changesin the composition of plant communities and a greater facilitation effect onthe establishment of invasive alien plants adjacent to the dung piles.Characteristics of the vegetation surrounding dung piles were recorded in 100?e25 cm plots located 0¡V1.5 m from theedge of the piles. We compared the immediate surroundings with reference plotsat 5 m. The diversity of plant species increased as distance from the edgeincreased from 0¡V1.5 m; however, species richness was significantly higher inthe first meter next to dung piles than 5 m away. Percentage cover of bareground decreased further from the dung piles at both scales. Percentage cover ofwoody plants was greater at greater distances from the manure, whereaspercentage cover of exotic plants was significantly higher next to the dungpiles. The reported changes could be related to concentration gradients ofnutrients liberated from the manure and\/or to behaviour patterns of the horses,which may avoid grazing in the immediate surroundings of dung piles. Thesechanges result in invasion windows facilitating the establishment andsubsequent dispersal of exotic plant species in grasslands.","palabras_clave":"Caballos cimarrones|Invasiones biol&oacute;gicas|Pastizales|Dispersi&oacute;n"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39403,"idioma_id":4,"titulo":"Synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents","resumen":"The synthesis of twelve acridine and polycyclic acridine derivatives prepared via the Friedländer reactionis described. The one-pot reactions of 2-amino-5-chloro or 5-nitro-benzophenones and a variety ofcyclanones and indanones were carried out in a MW oven under TFA catalysis in good yields. Theproducts were designed according natural antituberculosis products and were evaluated for growthinhibitory activity towards Mycobacterium tuberculosis H37Rv (Mtb) through the National Institute ofAllergy and Infectious Diseases (NIAID, USA). Three of them underwent additional testings. The cyclopenta[b]quinoline derivative 9 and the acridine derivative 13 showed remarkable MIC values against therifampin resistant strain. The former exhibited bactericidal activity at 50 mg\/mL, its intracellular activity issimilar to rifampin and it was not cytotoxic at low concentrations so it can be considered a new leadcompound.","palabras_clave":"MYCOBACTERIUM TUBERCULOSIS|ACRIDINE DERIVATIVES|FRIEDLAENDER SYNTHESIS|INHIBITOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39404,"idioma_id":4,"titulo":"Improved Fe2O3\/Al2O3 as Heterogeneous Fenton Catalysts for the Oxidation of Phenol Solutions in a Continuous Reactor","resumen":"AbstractBackgroundImproved Fe2O3\/Al2O3 catalysts were studied for the catalytic oxidation of concentrated phenol solutions (5 g\/L) with H2O2. To enhance catalyst stability, two strategies were investigated: the use of a high calcination temperature and a step of immersion into an organic acid solution. The reaction runs were performed in a continuous reactor at 70 ºC and atmospheric pressure.ResultsFor all the catalysts, almost complete phenol degradation was achieved. The mineralization levels were incomplete, reaching 60 and 50% for the catalysts treated with acetic and oxalic acid, respectively. The leaching levels were reduced from 25% (for the untreated catalyst) up to an 11% after the immersion in oxalic acid. In all cases, the formation of reversible carbonaceous deposits was observed during reaction and a progressively decay in phenol, TOC and H2O2 conversions was registered.ConclusionCatalyst resistance to leaching was significantly enhanced by means of combining both thermal and acidic treatments. These procedures did not affect the CWHPO performance in terms of mineralization levels. The lixiviation levels were acceptable, taking into account the strong acidic reaction medium. Deactivation processes might be primarily associated to the formation of reversible carbonaceous deposits due to intermediates accumulation onto the catalyst surface.","palabras_clave":"CWHPO|Fe2O3\/alumina|Fenton-like reaction|phenol removal"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39405,"idioma_id":4,"titulo":"Improved Fe2O3\/Al2O3 Systems for the Oxidation of a Model Organic Pollutant Using H2O2 as Oxidant","resumen":"Different Fe2O3\/Al2O3 catalysts (4 wt% Fe) were prepared and characterized by N2 physisorption, SEM-EDX, TGA and XRD. The systems were tested for the oxidation of high concentration phenol solutions (5 g\/L) in a batch reactor at 50 ºC, using H2O2 as oxidant. In order to enhance the catalyst stability two strategies were combined: an elevated temperature of calcination (900 °C) and pre-treatments with different organic acids (acetic, oxalic acid). The stability of the catalyst was improved significantly (leaching levels were reduced by up to 70%), with a good performance over the global oxidation process: mineralization levels of ca. 50% with oxidant consumption efficiencies of around 75%.","palabras_clave":"CWPO|H2O2|iron|lixiviation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39406,"idioma_id":5,"titulo":"Análisis de opciones reales como herramienta para evaluar el impacto de la regulación en la expansión de los sistemas eléctricos","resumen":"En los mercados eléctricos desregulados, el sistema de transmisión se convirtió en el principal medio que permite adecuadas condiciones de competencia en el sector de generación. Una expansión deficiente de las redes de transmisión impide los potenciales beneficios en términos de eficiencia asociados a los mecanismos de mercado. En consecuencia, es fundamental proporcionar políticas de inversión y señales económicas claras para atraer inversiones eficientes al sector de modo que el sistema de transmisión se desarrolle a mínimo costo, con niveles adecuados de calidad de servicio y confiabilidad, y adaptado a los requerimientos de generadores y consumidores. El presente trabajo propone la implementación de una herramienta moderna de evaluación económica que brinda al Regulador la capacidad de valorar distintos incentivos que permitan a los inversores tomar decisiones eficientes en ambientes de gran incertidumbre. La herramienta de evaluación se denomina Análisis de Opciones Reales. Esta técnica permite valorar en forma correcta las decisiones futuras que puede tomar un inversor como diferir, modificar o aplazar proyectos de inversión, en respuesta al arribo de nueva información o en la medida que las incertidumbres sean resueltas. Las decisiones se evalúan desde el punto de vista del agente inversor, el cual trata de maximizar sus ingresos en el periodo establecido para recuperar el capital invertido. Los resultados del trabajo permiten estudiar el comportamiento del agente inversor, respecto a la toma de decisión, cuando este tiene la posibilidad de administrar la opción de diferir, bajo distintos mecanismos regulatorios que incentiven la expansión del sistema de transmisión.","palabras_clave":"transmission system|planning|regulation|Real Options"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39407,"idioma_id":5,"titulo":"Los orbitales cuánticos y la autonomía del mundo químico","resumen":"El análisis del concepto de orbital permite argumentar ?en oposición a una propuesta reciente en filosofía de la ciencia? que no es posible defender la autonomía ontológica de la realidad química respecto de la física, sobre la base de una ruptura conceptual entre una interpretación química del concepto y otra propia de la mecánica cuántica. Esto es así porque no existen tales interpretaciones distintas del concepto de orbital, sino que, por el contrario, este concepto en química cuántica y en química estructural proviene de la mecánica cuántica.","palabras_clave":"Autonomía Ontológica de la Química|Química Cuántica|Funciones Monoelectronicas|Reducción Ontológica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39408,"idioma_id":5,"titulo":"Actores para un nuevo orden nacional  Los 'abogados de la Confederación' argentina: la idoneidad entre lo jurídico y lo político","resumen":"En septiembre de 1854, Justo José de Urquiza dio los primeros pasos para establecer el poder judicial a través de un decreto por el que estipulaba los requisitos y las formas de habilitación de los `abogados de la Confederación´ argentina. En el mismo, converge una serie de elementos que involucran nuestros problemas de investigación y que constituyen el núcleo de este artículo. Los debates legislativos sobre el decreto\/ley permiten recrear los términos del reconocimiento de los abogados en tanto personas idóneas para ejercer los cargos judiciales nacionales en su etapa de conformación. Dichos debates y las claves en las que se basaba dicha idoneidad, fundamentan una nueva lectura sobre el decreto y su significación en el contexto jurídico-político de esos años.El trabajo transita por hipótesis que involucran a las funciones públicas en un sentido amplio, y específicamente a la conformación del poder judicial nacional como fruto de una decisión política. Se enfatiza tanto en los requisitos de saber, como en las redes de relaciones y lealtades políticas y en las trayectorias públicas de los actores. Se relaciona la problemática con las redefiniciones de los vínculos político-institucionales de las autoridades provinciales y la nacional y del poder judicial con el ejecutivo y legislativo.","palabras_clave":"ABOGADOS|PODER JUDICIAL y PODER POLITICO|CONGRESO Y LEGISLACION|CONFEDERACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39409,"idioma_id":4,"titulo":"Progressive heart P-glycoprotein (P-gp) overexpression after experimental repetitive seizures (ERS) associated with fatal status epilepticus (FSE). Is it related with SUDEP?","resumen":"Patients with refractory epilepsy (RE) have increased risk of Sudden Unexpected Death in Epilepsy (SUDEP),where acute and fatal heart failure is suspected. High seizure frequency,polypharmacy, changes in dosing,  persistent low AED levels or poor adherence to therapy are the greatest risk factors of SUDEP and are also features observed in RE. We evaluated the progressive P-gp overexpression in heart, related with the development  of fatal status epilepticus (FSE) after experimental repetitive seizures (ERS). Male Wistar rats (180?230g) were daily injected (i.p) with Pentylenetetrazole (PTZ; 45mg\/kg; n=18) or saline (Controls; n=6). Severity of seizures was recorded. Four PTZ-treated rats were sacrificed at 4th-7th day respectively. Ten remaining rats, underwent same treatment until develop fatal status epilepticus (FSE). Brains and hearts were studied by immunofluorecent method for P-glycoptrotein (P-gp) expression. Seizures were observed each day of PTZ treatment, associated with a progressive P-gp overexpression in heart and FSE at 9th day. Using the same PTZ model, we previously demonstrated that progressive brain P-gp overexpression contributes to cell membrane depolarization of hippocampus and neocortex. These are the first evidences showing that ERS induces a simultaneous and progressive P-gp overexpression in brain and heart associated with FSE, and suggests a role for this pattern expression of P-gp as risk factor for death during SE. The simultaneous and spontaneous death of all animals during SE observed only at day 9th, suggest that a higher P-gp overexpression in cardiomyocytes could play a role in SUDEP, however, because it is only a study descriptive, further researches are needed to confirm this hypothesis.","palabras_clave":"P-GLICOPROTEIN|REPETITIVE SIZURES |PENTYLENETETRAZOL|SUDEP|STATUS EPILEPTICUS|MYOCARDIUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39410,"idioma_id":4,"titulo":"Mechanical anisotropy and thermo-acoustic properties of SnO2 under high pressures: an ab-initio approach","resumen":"The effects of hydrostatic pressures on the electronic, thermoacoustic and elastic anisotropies of SnO2 inthe rutile structure is analyzed up to 18 GPa. It is found that the polycrystalline bulk modulus B increasesfrom 227 to 312 GPa between 0 and 18 GPa while the Young and shear moduli slightly decrease withpressures. The resulting polycrystalline ductility increases with pressures. The speed of the sound forlongitudinal waves increases with pressure, while the transverse polarizations and the Debye temperaturedecrease. Large crystal anisotropy for the shear planes {001} between 110 and 010 directions underpressures, associated with the phase transition to the Cl2 Ca, is found.","palabras_clave":"Ceramic Oxides|Electronic and elastic properties|anisotropy|tenacity under pressures"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39411,"idioma_id":4,"titulo":"Nonlinear Optical Microscopy Signal Processing Strategies in Cancer","resumen":"This work reviews the most relevant present-day processing methods used to improve the accuracy of multimodal nonlinear images in the detection of epithelial cancer and the supporting stroma. Special emphasis has been placed on methods of non linear optical (NLO) microscopy image processing such as: second harmonic to autofluorescence ageing index of dermis (SAAID), tumor-associated collagen signatures (TACS), fast Fourier transform (FFT) analysis, and gray level co-occurrence matrix (GLCM)-based methods. These strategies are presented as a set of potential valuable diagnostic tools for early cancer detection. It may be proposed that the combination of NLO microscopy and informatics based image analysis approaches described in this review (all carried out on free software) may represent a powerful tool to investigate collagen organization and remodeling of extracellular matrix in carcinogenesis processes.","palabras_clave":"nonlinear signal|nonlinear microscopy|anisotropy, gray level co-occurrence matrix|tumor-associated collagen signatures"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39412,"idioma_id":4,"titulo":"Morphological and genetic variability in an alien invasive mussel across an environmental gradient in South America","resumen":"Adaptation is an essential step in the establishment and spread of alien species in new environments, with phenotypic plasticity or genetic variability often contributing to this success. The golden mussel Limnoperna fortunei is a biofouling mollusc native to Southeast Asia that was introduced to South America near the Río de la Plata estuary, Argentina, though the species has subsequently spread more than 2000 km upstream. We analyzed morphological and genetic variation in 24 introduced populations of L. fortunei across its South American range. Relative gill area and shell morphology differed significantly, even among geographically proximate populations. Differences in relative gill area were especially marked across the species´ range, and negatively correlated with total suspended solids. While mean gill cilia length, filament width, and inter-filamental ciliary junction distance did not differ significantly among populations, mean gill cilia density was significantly lower in populations from areas with high suspended solids. Conversely, morphological differences were not related to the number of haplotypes, haplotype diversity, or nucleotide diversity, based upon analyses of the mitochondrial cytochrome c oxidase subunit 1 (COI) gene. Our results indicate that introduced populations of golden mussels in South America exhibit pronounced morphological variation in shell and gill metrics that appear to result from developmental plasticity in relation to total suspended sediments, as has been observed in other mussel species. These adaptations may have facilitated spread of this species to a wide range of habitats.","palabras_clave":"LIMNOPERNA FORTUNEI|INVASION ECOLOGY|POPULATION GENETICS|MORPHOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39413,"idioma_id":4,"titulo":"Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice","resumen":"Chronic use of methamphetamine (METH) leads to long-lasting  cognitive dysfunction in humans and in animal models. Modafinil is a  wake-promoting compound approved for the treatment of sleeping disorders. It is  also prescribed off label to treat METH dependence. In the present study, we  investigated whether modafinil could improve cognitive deficits induced by  sub-chronic METH treatment in mice by measuring visual retention in a Novel  Object Recognition (NOR) task. After sub-chronic METH treatment (1 mg\/Kg, once  a day for 7 days), mice performed the NOR task, which consisted of habituation  to the object recognition arena (5 min a day, 3 consecutive days), training  session (2 equal objects, 10 min, day 4), and a retention session (1 novel  object, 5 min, day 5). One hour before the training session, mice were given a  single dose of modafinil (30 or 90 mg\/Kg). METH-treated mice showed impairments  in visual memory retention, evidenced by equal preference of familiar and novel  objects during the retention session. The lower dose of modafinil (30 mg\/Kg)  had no effect on visual retention scores in METH-treated mice, while the higher  dose (90 mg\/Kg) rescued visual memory retention to control values. We also  measured ERK phosphorylation in medial prefrontal cortex (mPFC), hippocampus,  and nucleus accumbens (NAc) of METH- and vehicle-treated mice that received  modafinil 1 hr before exposure to novel objects in the training session,  compared to mice placed in the arena without objects. Elevated Extracellular  signal-regulated kinase (ERK) phosphorylation was found in the mPFC of  vehicle-treated mice, but not in METH-treated mice, exposed to objects  (p<0.05). The lower dose of modafinil had no effect on ERK phosphorylation  in METH-treated mice, while 90 mg\/Kg modafinil treatment restored the ERK  phosphorylation induced by novelty in METH-treated mice to values comparable to  controls (p<0.05). We found neither a novelty nor treatment effect on ERK  phosphorylation in hippocampus or nucleus accumbens (NAc) of vehicle- and  METH-treated mice receiving acute 90 mg\/Kg modafinil treatment. Our results  showed a palliative role of modafinil against METH-induced visual cognitive  impairments, possibly by normalizing ERK signaling pathways in mPFC. Modafinil  may be a valuable pharmacological tool for the treatment of cognitive deficits  observed in human METH abusers as well as in other neuropsychiatric conditions.","palabras_clave":"METHAMPHETAMINE|NOVELTY|ERK|PREFRONTAL CORTEX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39414,"idioma_id":4,"titulo":"Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: Effect of androgens","resumen":"Transgenic female mice overexpressing the &#945;- and &#946;- subunits of human chorionic gonadotropin (hCG&#945;&#946;+) exhibited precocious puberty, as evidenced by early vaginal opening. Chronically elevated hCG in 21-day-old hCG&#945;&#946;+ females stimulated gonadal androgen production, which exerted negative feedback over the endogenous gonadotropin synthesis, and activated the hypothalamic GnRH pulsatility and gene expression. Transgenic females also exhibited elevated hypothalamic aromatization in the preoptic area (POA), which is the sexually-differentiated area that controls the LH surge in adulthood. Ovariectomy at 14days of age was unable to rescue this phenotype. However, the blockade of androgen action by flutamide from postnatal day 6 onwards reduced the aromatase levels in the POA of hCG&#945;&#946;+ females. Our results suggest that early exposure of females to androgen action during a critical period between postnatal days 6-14 induces sex-specific organizational changes of the brain, which affect the aromatase expression in the POA at the onset of precocious puberty.","palabras_clave":"AROMATASE|HUMAN CORIONIC GONADOTROPIN|HYPOTHALAMIC-PITUITARY-GONADAL AXIS|PRECOCIOUS PUBERTY|TRANSGENIC MICE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39415,"idioma_id":4,"titulo":"Hydrogen absorption and desorption in the Mg-Ag system","resumen":"We analyze hydrogen absorption and desorption in Mg and Mg?Ag compounds prepared by mechanical milling. The materials were obtained by processing mixtures of Mg or MgH2 with different proportions of Ag under Ar or H2 atmosphere.We observe that Ag and AgMg destabilize MgH2. In the first case the products of the reaction of Ag and MgH2 are AgMg and H2, in the second case MgH2 reacts with AgMg to give AgMg4 and H2. The first reaction was only observed in the forward direction, whereas the second one was registered in both directions. The impossibility to reverse the first reaction was attributed to poor kinetics and experimental limitations. The reversible destabilization induced by AgMg is low, MgH2 overall dehydriding enthalpy is reduced from 76.5 kJ\/mol H2 to 69.1 kJ\/mol H2. This last value allowed us to estimate the formation enthalpy of AgMg4 at -59.5 kJ\/mol.Besides destabilization, a slight improvement in hydrogen absorption kinetics and a more noticeable enhancement in desorption kinetics has been observed in samples containing Ag as an additive. During thermal desorption, the dehydriding temperature decreases by 20 ºC. In isothermal desorption experiments at 325 ºC, the characteristic induction period of MgH2 without additive practically disappears, and the time to reach 50% of conversion decreases from 17 min to 5.4 min when silver is present. The changes in desorption kinetics could be attributed to AgMg or the interfaces MgH2\/AgMg acting as nucleation sites for Mg.","palabras_clave":"HYDROGEN ABSORBING MATERIALS|INTERMETALLICS|MECHANICAL MILLING|THERMODYNAMIC DESTABILIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39416,"idioma_id":4,"titulo":"Habitat degradation and introduction of exotic plants favor persistence of invasive species and population growth of native polyphagous fruit fly pests in a Northwestern Argentinean mosaic","resumen":"Expansion of agricultural land is one of the most significant human alterations to the global environment because it entails not only native habitat loss but also introduction of exotic species. These alterations affect habitat structure and arthropod dynamics, such as those among host plants, tephritid fruit flies, and their natural enemies. We compared abundance and dynamics of pest and non-pest tephritids and their natural enemies over a mosaic of habitats differing in structure, diversity and disturbance history on the Sierra de San Javier in Tucuman, Argentina.Our prediction was that conserved habitats would be more resistant to the establishment and spread of invasive tephritid species due in part to a greater abundance of natural enemies, a greater diversity of native species in the same family and trophic level, and a greater wealth of biotic interactions. We further predicted that native species with broad host ranges should be more sensitive to habitat loss yet more competitive in less disturbed habitats than generalist native and exotic species. We found that environmental degradation, and introduction and spread of exotic host plants strongly affected distribution patterns, abundance, and phenology of native and exotic tephritids. Monophagous tephritid species and several specialized parasitoids were more sensitive to habitat loss than polyphagous species and parasitoids exhibitinga wide host range. In contrast, native monophagous species and native parasitoids appeared to exclude the invasive Mediterranean fruit fly fromconserved patches of native vegetation. Nevertheless, the Mediterranean fruit fly persisted in uncontested exotic host plants and thrived in highly degradeted urban landscapes.","palabras_clave":"CERATITIS CAPITATA|ANASTREPHA SPP.|PARASITOIDS|FRAGMENTATION|YUNGAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39417,"idioma_id":5,"titulo":"Colecciones del Laboratorio de Paleobotánica y Procesamiento de Material Sedimentario del CICYTTP-Diamante (CONICET), Entre Ríos, Argentina","resumen":"En esta contribución se dan a conocer las colecciones del Laboratorio de Paleobotánica y el Laboratorio de Procesamiento de Material Sedimentario. Se describen los protocolos de los tratamientos y los mecanismos de resguardo del material depositado en dichas colecciones.","palabras_clave":"COLECCIONES|PALEOBOTÁNICA|MATERIAL SEDIMENTARIO|CICYTTP-CONICET, DIAMANTE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39418,"idioma_id":5,"titulo":"Excavaciones arqueológicas en el área fundacional de la ciudad de Córdoba, Argentina. Dean Funes 67","resumen":"Se presentan los primeros resultados de la intervención arqueológica, dentro del marco de un estudio de impacto, en un local comercial situado en el Barrio Centro de la ciudad de Córdoba. La parcela en estudio se encuentra localizada e escasos metros del Cabildo de la ciudad por lo que su estudio cobra importancia para el análisis de las formas de uso del espacio en la zona central de la ciudad a lo largo de más de 400 años de ocupación.  Durante las excavaciones se hallaron diversos objetos (metal, vidrio, cerámica utilitaria, loza y restos de huesos) y una estructura arquitectónica. Esta última se trata de un muro de calicanto que permite asignar los restos al menos a tres momentos. Uno temprano que correspondería al Siglo XVIII, y dos posteriores correspondientes a los siglos XIX y XX  Con esto se evidencia la importancia de mitigar el impacto negativo que las nuevas construcciones producen sobre el registro arqueológico -oculto a quienes transitan asiduamente por su superficie- que enriquece y complementa la historia documental de la ciudad.","palabras_clave":"arqueología urbana|área fundacional|Córdoba|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39419,"idioma_id":5,"titulo":"Filosofar desde sujetos y procesos liberadores de Nuestra América","resumen":"                    Quienes conformamos, desde 1999, la Cooperativa   Filosófica Pensamiento del Sur exponemos los temas de nuestras actuales  investigaciones en diferentes ámbitos académicos, pero desde un proyecto común  de pensamiento filosófico situado en Nuestra América. Los núcleos problemáticos  y temáticas comunes son: la crítica del capitalismo, los procesos  emancipatorios, la democracia, la reivindicación de la utopía y la relación de  la filosofía con las ideologías y las ciencias sociales. Todo ello estimulados  con la interlocución del filósofo Horacio Cerutti Guldberg.   ","palabras_clave":"FILOSOFAR|SUJETOS|PROCESOS|NUESTRA AMÉRICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39420,"idioma_id":4,"titulo":"Can we heal Chagas infection?","resumen":"We present a model for the parasite-antibody dynamical competition between Trypanosoma rangeli and its antibodies during the acute phase of an infection in a mammal host. The model reproduces experimental data from murine models found in the literature and allows us to demonstrate that a preinfection with T. rangeli induces a temporary protective effect against Chagas disease. As the mammal immune system is able to eliminate a single T. rangeli infection, the host high antibody levels, needed to resist the Chagas infection, are reduced with time, returning the system to the initial healthy state. Our results suggest that a preinfection with T. rangeli could be used to reduce the in-house vectorial parasitemia through repeated vaccination of domestic animals.","palabras_clave":"Trypanosoma rangeli|Trypanosoma cruzi|Chagas disease|Mathematical modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39421,"idioma_id":4,"titulo":"Synthesis, characterization of mesoporous silica powders and application to antibiotic remotion from aqueous solution Effect of supported Fe-oxide on the SiO2 adsorption properties","resumen":"The remotion of the antibiotic minocycline (MC) on mesoporous silica (SiO2) and on the binary system iron(III) oxide-SiO2 (Fe-SiO2) has been studied in batch experiments by performing adsorption isotherms\/kinetics under different conditions of pH, KCl concentration and temperature. The adsorption of MC on the studied materials is strongly dependent on pH, increasing as pH decreases. The incorporation of a low concentration of iron (1.03 wt %, mainly as amorphous Fe2O3) on the SiO2 matrix not only increases the adsorption capacity but also changes the adsorption mechanism. The adsorption of MC on SiO2 strongly decreases as KCl concentration increases but it is not significantly affected by varying the temperature. This is attributed to electrostatic attractions and H-bond formations between dimethylamino, amide, carbonylic and phenolic groups of the antibiotic and the functional groups of silica particles. The adsorption of MC on Fe-SiO2, on the contrary, strongly increases as temperature increases but remains invariable by varying the KCl concentration. This suggests that the formation of inner-sphere complexes between the functional groups of the antibiotic and the active sites of Fe2O3 plays a key role on the adsorption mechanism. The analysis of adsorption thermodynamic parameters is also reported and discussed. The synthesized materials can act as excellent adsorbents for environmental and engineering processes.","palabras_clave":"Mesoporous silica|Composed materials|Minocycline adsorption|Surface complexes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39422,"idioma_id":4,"titulo":"Analysis of metal profile in soybean after cadmium-induced oxidative damage","resumen":"Toxic  heavy metals enter plant cells through transport systems involved in  macro-micronutrient uptake. The effect of Cd on soybean (Glycine maxL.) and the relationship with the distribution and  concentration of macro-microelements was analysis. The accumulated amount of  dry matter in roots and leaves of soybean seedlings was lower in the Cd-treated  than in the control group. Regression analysis showed that the exposure to Cd  affected the accumulated amount of dry matter as well as the content of mineral  elements in the analysis samples. In Cd treated plants, electrical conductivity  increased respect to the controls, 18.22%, 15.13% and 10.24% at 6 h, 24 h and  72 h respectively, indicating that ionic permeability became altered. A strong  inhibition of the chlorophylls biosynthesis in the Cd-treated group was also  demonstrated by a decrease of clha and  clhb concentration. This result was related with the observed significant  decrease in the Mg uptake at the roots and leaves level. The results  demonstrated that in stress caused by Cd exposure of soybean seedlings,  evidenced by significantly high peroxide levels in roots and leaves after 24 h,  the content of specific macro-microelements is a factor that affects the  accumulation of dry matter, ionic permeability and chlorophyll concentration.","palabras_clave":"SOJA|MACRO-MICRO ELEMENTOS|CLOROFILA|CADMIO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39423,"idioma_id":4,"titulo":"BioPlat: a software for human cancer biomarker discovery","resumen":"Summary: Development of effective tools such as oligo-microarraysand next-generation sequencing methods for monitoring gene expressionon a large scale has resulted in the discovery of gene signatures15 with prognostic\/predictive value in various malignant neoplastic disAQ4eases. However, with the exponential growth of gene expression databases,biologists are faced with the challenge of extracting usefulinformation from these repositories. Here, we present a software package,BioPlat (Biomarkers Platform), which allows biologists to identify20 novel prognostic and predictive cancer biomarkers based on the datamining of gene expression signatures and gene expression profilingdatabases. BioPlat has been designed to be an easy-to-use and aflexible desktop software application, which provides a set of analyticaltools related to data extraction, preprocessing, filtering, gene ex-25 pression signature calculation, in silico validation, feature selection andannotation that leverage the integration and reuse of gene expressionAQ5 signatures in the context of follow-up data.Availability and implementation: BioPlat is a platform-independentsoftware implemented in Java and supported on GNU\/Linux and MS30 Windows, which is freely available for download at http:\/\/www.cancergenomics.net.Contact: mcabba@gmail.comSupplementary information: Supplementary data are available at","palabras_clave":"BIOPLAT|BREAST CANCER|GENE SIGNATURE|BIOINFORMATIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39424,"idioma_id":4,"titulo":"Reusing Design experiences to Materialize Software Architectures into Object-oriented Designs","resumen":"Software architectures capture early design decisions about a system in order to fulfill relevant quality attributes. When moving to detailed design levels, the same architecture can accept many different object-oriented implementations. A common problem here is the mismatches between the quality-attribute levels prescribed by the architecture and those realized by its object-oriented materialization. A significant step towards reducing those  mismatches is the provision of tool support for assisting developers in the materialization of software architectures. Prerequisites to develop materialization tools are the organization of a body of design knowledge and the definition of quality-driven reasoning procedures.  Since materialization activities are mainly driven by past developers? experiences, we propose a Case-based Reasoning (CBR) approach that, through the codification of design experiences, permits to establish links between software architecture structures and object-oriented counterparts. This approach is supported by an Eclipse-based tool, called SAME (Software Architecture Materialization Environment), which is a reuse-oriented  assistant to the developer. SAME is able to recall and adapt successful architecture materializations for particular quality attributes, in order to help the developer to derive an appropriate object-oriented design for his\/her architecture.","palabras_clave":"quality attributes|object-oriented designs|tool support"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39425,"idioma_id":4,"titulo":"Using constraint satisfaction to aid group formation in CSCL","resumen":"In computer-supported collaborative learning contexts, group formation is a key aspect, since different characteristics of students might influence the group performance. In this article, we present an intelligent assistant that models group formation as a weighted constraint satisfaction problem (WCSP). The assistant takes into account three students? features, namely: psychological styles, team roles and social networks. The proposed WCSP approach is able to combine constraints and preferences both for individuals and groups. The main goal of the assistant is to aid teachers to form learning groups considering factors such as team role balance and  distribution of psychological styles. We also describe a pilot study to evaluate our proposal in different scenarios.","palabras_clave":"COMPUTER-SUPPORTED COLLABORATIVE LEARNING|GROUP FORMATION|CONSTRAINT SATISFACTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39426,"idioma_id":4,"titulo":"Assisting Requirements Analysts to Find Latent Concerns with REAssistant","resumen":"Textual requirements are very common in software projects. However, this format of requirements often keeps relevant concerns (e.g., performance, synchronization, data access, etc.) from the analyst´s view because their semantics are implicit in the text. Thus, analysts must carefully review requirements documents in order to identify key concerns and their effects. Concern mining tools based on NLP techniques can help in this activity. Nonetheless, existing tools cannot always detect all the crosscutting effects of a given concern on different requirements sections, as this detection requires a semantic analysis of the text. In this work, we describe an automated tool called REAssistant that supports the extraction of semantic information from textual use cases in order to reveal latent crosscutting concerns. To enable the analysis of use cases, we apply a tandem of advanced NLP techniques (e.g, dependency parsing, semantic role labeling, and domain actions) built on the UIMA framework, which generates different annotations for the use cases. Then, REAssistant allows analysts to query these annotations via concern-specific rules in order to identify all the effects of a given concern. The REAssistant tool has been evaluated with several case-studies, showing good results when compared to a manual identification of concerns and a third-party tool. In particular, the tool achieved a remarkable recall regarding the detection of crosscutting concern effects.","palabras_clave":"Concern Mining|User Assistance|Tool Support|Semantic Analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39427,"idioma_id":4,"titulo":"Simple wavelength-to-phase mapping FBG´s interrogation method","resumen":"In this work, an interrogation method for FBG sensors is presented based on a wavelength-to-time transformation procedure. The proposed scheme uses an externally modulated broadband source, an optical circulator and three Bragg gratings fixed in three different fiber branches, one acting as sensor (FBGS) and others two (FBG1 and FBG2) acting as wavelength calibration devices. Spectral positions of the reflectivity maximum of FBG1,2 are slightly different and fixed while FBGS spectral position lies in the reflection spectral range of FBG1,2. Moreover, an optical time delay between the reflections of both calibration gratings is introduced including a path length greater in one of the branches. Reflections from both gratings are added by employing a 50\/50 coupler. By this set-up, a phase sensible detection technique is generated allowing to reach a sensitivity of up to 660 1\/nm in the performed experiments. A theoretical analysis of the device performance was carried out showing good agreement with the experimental results. This system combines low cost and high flexibility to be customized in a particular application.","palabras_clave":"Optical fiber Sensor  |Bragg grating|Optical interrogator |Phase detection"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39429,"idioma_id":4,"titulo":"Spin response of impurities in a quantum corral","resumen":"In this work we investigate the dependence of spin observables, like the total spin alignment and the spin squeezing factor, for electrons confined inside an elliptic quantum corral and interacting with a pair of impurities located on the semi-major axis of the ellipse. The results suggest that such a system exhibits some of the characteristic features of a qubit, concerning the persistence of the orientation and squeezing of a component of the total spin.","palabras_clave":"QUANTUM CORRALS|ELLIPTICAL BOUNDARIES|CONFINED ELECTRONS AND IMPURITIES|SPIN SQUEEZING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39430,"idioma_id":4,"titulo":"A scientific note on the first report of honeybee venom inhibiting  Paenibacillus larvae growth","resumen":"Honeybee venom (BV) has been recently reported as an  important source of antimicrobial peptides. Despite these broad spectrum  antimicrobial effects, information about BV effects on infectious pathogens of  honeybees is previously absent from the literature. It is a preliminary  approach about an alternative natural substance for American Foulbrood control.  Results showed that very low concentrations of BV are required to inhibit Paenibacillus larvae vegetative cells  growth. The minimal inhibitory concentration values ranged from 3.12 to 8.33  µg\/mL, and minimal bactericidal concentration values of 4.16 to 10.42 &#956;g\/mL. This  paper is the first report on BV antimicrobial activity against P. larvae with no lethal or behavioral  effects on bees.","palabras_clave":"Apis mellifera|Paenibacillus larvae|Bee venom|antimicrobial activity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39431,"idioma_id":4,"titulo":"Effect of land use intensification on specialization in plant-floral visitor interaction networks in the Pampas of Argentina","resumen":"Land use intensification reduces natural areas and alters landscape heterogeneity diminishing species richness and changing ecosystem functionality. The analysis of interaction networks is a useful tool for estimating the degree of change experienced by ecosystems. Here, plant?floral visitor networks from fragments of grassland restored by agricultural activities discontinued over a long time were compared with networks from agriculturalized fragments nearby. The hypothesis evaluated was that land use intensification changes the structure of the original networks by modifying species richness and the network degree of specialization. The study was carried out at three sites located over a 700 km transect across the provinces of Buenos Aires and La Pampa, Argentina. At each site, four fragments were selected (two restored and two agricultural). Five monthly samplings were taken between November and March along three consecutive years. Entomophilous plants and their floral visitors were identified and all plant?floral visitor interactions were recorded. With these data, richness of plants and visitors were calculated, interaction networks were constructed and the degree of specialization was calculated for each network. Land use intensification caused changes in the community composition and degree of specialization. When cropping was the predominant farming enterprise, richness of floral visitors and plants decreased as compared to restored fragments. When cattle production was the predominant land use, richness of floral visitors remained stable. However, at one of the sites plants richness was 48% higher in the grazed fragments than in those restored. In the agricultural fragments, the abundance of units of floral attraction due to exotic plants increased, but the visitation rates were the same as in the restored fragments. The networks in the agricultural fragments were more generalist than in restored fragments, in agreement with previous studies on the effect of land use intensification on natural systems.","palabras_clave":"DEGREE OF SPECIALIZATION |PLANT-POLLINATIOR NETWORKS|AGRO-ECOSYSTEMS| LAND USE INTENSIFICATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39432,"idioma_id":5,"titulo":"Fecundidad y consumo de oxigeno del  cangrejo dulceacuícola Trichodactylus borellianus (Decapoda: Trichodactylidae) en el valle aluvial del Paraná Medio (Argentina)","resumen":"En el presente trabajo se analiza la fecundidad de Trichodactylus borellianus en el área del Paraná Medio (Argentina) y el consumo de oxígeno de hembras ovígeras en condiciones experimentales. Se obtuvieron los valores medios y desvío estándar de fecundidad (96 ± 36 huevos), masa húmeda de huevos (0.11 ± 0.08 g), volumen del huevo (0.40 ± 0.08 mm3) y esfuerzo reproductivo (0.22 ± 0.1). El consumo de oxígeno difirió entre hembras ovígeras, hembras no ovígeras y machos, y también entre hembras ovígeras con los huevos en diferentes estadios de desarrollo. El consumo de oxígeno en hembras ovígeras de T. borellianus muestra una tendencia a invertir energía simultáneamente en el cuidado parental de incubación de los huevos y en el desarrollo de gónadas para optimizar su reproducción.","palabras_clave":"decápodos|hembras ovigeras|ambientes continentales|América del sur"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39433,"idioma_id":4,"titulo":"Combined Experimental and Computational Investigation of the Fluorescence Quenching of Riboflavin by Cinnamic Alcohol Chemisorbed on Silica Nanoparticles","resumen":"ABSTRACT: Riboflavin (vitamin B2) is usually present in water courses, lakes, and seas and acts as a photosensitizer in the photo-oxidation of a range of contaminants.  However, little is known about the interaction of this compound with aromatics sorbed on silica sediments or on suspended silica particles. This article describes the modification and characterization of silica nanoparticles by condensation of the silanol groups of the particles with E-cinnamic alcohol. The reaction was confirmed by Fourier transform infrared spectroscopy (FTIR), solid-state 13C and 29Si crosspolarization  magic angle spinning (CPMAS) NMR, reduction of the specific surface  area measured by BET, thermal analysis, and fluorescence spectroscopy. Toxicity to the marine bacteria Vibrio fischeri of the modified particles was also measured.  Riboflavin fluorescence was quenched in aqueous medium in the presence of  dissolved E-cinnamic alcohol or in suspensions of the modified particles. The results are interpreted in terms of formation of 1:1 complexes between the ground states of riboflavin and the free or adsorbed cinnamic alcohol. Density functional theory (DFT) calculations in aqueous medium support the existence of the complex and explain the observed quenching of riboflavin fluorescence upon addition of cinnamic alcohol  without affecting the emission maximum of riboflavin.","palabras_clave":"Fluorescence Quenching|Silica Nanoparticles|Riboflavin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39434,"idioma_id":4,"titulo":"CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia\/reperfusion injury","resumen":"Ca2+-Calmodulin kinase II (CaMKII) activation is deleterious in cardiac ischemia\/reperfusion (I\/R).  Moreover, inhibition of CaMKII-dependent phosphorylations at the sarcoplasmic reticulum (SR)prevents CaMKII-induced I\/R damage. However, the downstream targets of CaMKII at the SR level,responsible for this detrimental effect, remain unclear.  In the present study we aimed to dissect the role of the two main substrates of CaMKII at the SR level,phospholamban (PLN) and ryanodine receptors (RyR2), in CaMKII-dependent I\/R injury.  In mouse hearts subjected to global I\/R (45\/120 min), phosphorylation of the primary CaMKII sites,S2814 on cardiac RyR2 and of T17 on PLN, significantly increased at the onset of reperfusion whereas PKA-dependent phosphorylation of RyR2 and PLN did not change. Similar results were  obtained in vivo, in mice subjected to regional myocardial I\/R (1\/24 hrs). Knock-in mice with an inactivated serine 2814 phosphorylation site on RyR2 (S2814A), significantly improved post-ischemic  mechanical recovery, reduced infarct size and decreased apoptosis. Conversely, knock-in mice, in which CaMKII site of RyR2 is constitutively activated (S2814D), significantly increased infarct size  and exacerbated apoptosis. In S2814A and S2814D mice subjected to regional myocardial ischemia, infarct size was also decreased and increased respectively. Transgenic mice with double-mutant non-phosphorylatable PLN (S16A\/T17A) in the PLN knockout background (PLNDM) also showed significantly increased post-ischemic cardiac damage. This effect cannot be attributed to PKAdependent PLN phosphorylation and was not due to the enhanced L-type Ca2+ current, present in these  mice.  Our results reveal a major role for the phosphorylation of S2814 site on RyR2 in CaMKII-dependent I\/R cardiac damage. In contrast, they showed that CaMKII-dependent increase in PLN phosphorylation during reperfusion opposes rather than contributes to I\/R damage.","palabras_clave":"RYR2|PLN|CAMKII|ISCHEMIA\/REPERFUSION INJURY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39435,"idioma_id":4,"titulo":"Revised timing of the South American early Paleogene land mammal ages","resumen":"A new Ar\/Ar date on the Las Flores Tuff (Río Chico Group, Las Flores Fm., central Patagonia, Argentina)yielded an age of 49.512 ± 0.019 Ma. This tuff, which stratigraphically overlies the mammal-bearing deposits that produced the Las Flores fauna, helps constrain the age of the Itaboraian SALMA [South American Land Mammal Age] to which that fauna is referred. The new data also have implications for the age of succeeding mammal biochrons, such as the Riochican and ?Sapoan? which are revised to beingsomewhat younger than previously interpreted. Although closer in age than formerly interpreted, they still are biotically distinct. Concomitant evaluations suggest that the Itaboraian SALMA is perhaps more contemporary with the EECO (Early Eocene Climatic Optimum) than previously considered. The Riochican may be interpreted as post-EECO, with its cooler climate consistent in that regard. A recent reconsideration of the chronology of elements of the Salamanca Formation resulted in the downward revision of the ages of the Peligran SALMA and the Carodnia Zone biochrons. These operations, together with our results, reflect a 9 m.y. gap in the late Paleocene and early Eocene land mammal record in South America.","palabras_clave":"Paleógeno|Itaboraiense|Formación Las Flores |Patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39436,"idioma_id":4,"titulo":"The optimization of the culture medium to design Streptomyces sp. M7 based impedimetric biosensors","resumen":"tElectrochemical impedance has been widely used in microbiology in detection, quantifying and identify-ing microorganisms. Streptomyces strain M7 (SM7) is capable to grow in the presence of organochlorinepesticides (OCPs) as carbon source, using the amino acid asparagine as nitrogen source. This bacte-rial growth can be valuable and hence used in an impedimetric biosensor to detect and, eventually,quantify these pesticides. Since amino acids frequently used in culture media interfere in impedancedeterminations, this work presents an optimized design regarding the culture medium capabilities onthe impedance response of SM7 activity, as a first stage toward the development of an impedimetricbiosensor to detect OCPs. With such a purpose, SM7 growth in liquid or adhered to a solid media wasmeasured by impedance in the presence of asparagine or (NH4)2SO4as nitrogen source and glucose asa model carbon source. Impedimetric SM7 measurements were performed in the Quantibac instrumentthat can be employed to evaluate the metabolic behavior of microorganisms in different culture mediausing two fixed frequencies. We found that SM7 used asparagine as carbon source in the absence of glu-cose. Since this consumption strongly contributed to the impedance signal, this is not a suitable mediumto be used with an impedimetric biosensor. On the other hand, (NH4)2SO4appears as an ideal mediumbecause it supports SM7 growth in liquid and solid media without interfering the impedimetric detection.This simple and cost-effective technique combined with a spore-based platform is a promising strategyto design OCPs bacteria-based biosensors.","palabras_clave":"Carbon Source|Nitrogen Source|Impedance|Lindane"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39437,"idioma_id":4,"titulo":"A jellyfish diet for the herbivorous green turtle Chelonia mydas in the temperate SW Atlantic","resumen":"Feeding ecology of juvenile green turtles (Chelonia mydas) was studied from 2008 to 2011 at Samborombon Bay (36°30 -36°30'S, Argentina) combinig data on digestive tract examination and isotope stable analysis through a Bayesian mixing model. We found that animal matter, in particular gelatinous plankton, was consumed in large proportions compared to herviborous food items such as terrstrial  plants and macroalgae. This diet is facilitate by the high abundances of gelatinous plankton in the regiosn, thus confirming the adatative foraging behavior of the juveniles according to prey abundance in the SW Atlantic. To our knowledge, this is the firts study to employ this combination of techniques and to conclusively demostrates, that animal m,atter, in particular gelatinous plankton, is important in the diet of the neritic green sea turtles.","palabras_clave":"CHELONIA MYDAS|JELLYFISH|DIET|STABLE ISOTOPES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39438,"idioma_id":4,"titulo":"Isoconductivity method to study adhesion of yeast cells to gold electrode","resumen":"In this paper, we used impedance spectroscopy and gold electrodes to detect the presence of yeast cells and monitor the attachment of these cells to the electrodes. We analysed the effect of conductivity changes of the medium and the attachment on the electrode-electrolyte interface impedance. A three-electrode cell was designed to produce a uniform electric field distribution on the working electrode and to minimise the counter electrode impedance. Moreover, we used a small AC overpotential (10 mV) to keep the system within the linear impedance limits of the electrode-electrolyte interface. This study proposes a new method to differentiate the impedance changes due to the attachment of yeast cells from those due to conductivity changes of the medium. The experiments showed that when the difference between the cell suspension and base solution conductivities is within the experimental error, the impedance changes are only due to the attachment of yeast cells to the electrodes. The experiments also showed a strong dependence (decrease) of the parallel capacity of the electrode electrolyte interface with the yeast cell concentration of suspension. We suggest that this decrease is due to an asymmetrical redistribution of surface charges on both sides of cell, which can be modelled as a biologic capacity connected in series with the double layer capacity of the interface. Our results could help to explain the rate of biofilm formation through the determination of the rate of cell adhesion.","palabras_clave":"yeast|impedance|attachment|frequency"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39439,"idioma_id":4,"titulo":"Kinetic modelling of thermal inactivation of a keratinase from Purpureocillium lilacinum LPSC # 876 and the influence of some additives on its thermal stability","resumen":"Thermal  inactivation of a keratinase produced by Purpureocillium lilacinum LPSC #876  was kinetically investigated using several enzyme inactivation models at the  temperature range of 50 ? 65 °C. Among the models studied, the Weibull  distribution was the best model that describes the residual activity of P.  lilacinum keratinase after heat treatment over the selected temperatures. The  stabilising effect of metal ions (Ca 2+ or Mg 2+ , 5 mmol l &#8722; 1 )or polyols (propylene glycol and glycerol, 10 % v\/v)  was investigated, showing that the presence of Ca 2+ increases the enzyme stability significantly.  Conforming to the increased Ca 2+ concentration, thermal stability of the enzyme also  increased, with 10 mM of Ca 2+ being the concentration of metal in which the enzyme  retained 100 % of its original activity after being incubated for 1 h at 55 °C.  The effects of temperature on Weibull equation parameters and on the  characteristics of the inactivation curves were evaluated. In the absence of  any additives (control), the reliable time ( t R ) of the keratinase, analogous to D value, ranged from  484.16 to 63.67 min, while in the presence of Ca 2+ the t R values ranged from 6,221 to 414.95 min at 50 ? 65 °C. P. lilacinum keratinase is a potentially useful  biocatalyst, and therefore, kinetic modelling of thermal inactivation addresses  an important topic for its application in various industrial processes&nbsp;     ","palabras_clave":"Keratinase Weibulldistribution| Thermal stability | Kinetic modelling| Weibull distribution| Calcium and polyols"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39440,"idioma_id":4,"titulo":"Immobilization of a keratinolytic protease from Purpureocillium lilacinum on genipin activated-chitosan beads","resumen":"Keratinase from Purpureocillium lilacinum LPSC # 876 was immobilized on chitosan  beads using two different cross-linking agents: glutaraldehyde and genipin. For  its immobilization certain parameters were investigated such as cross-linker  concentration, activation time and activation temperature. Under optimum  conditions, immobilization yield resulted to be 96 and 92.8 % for  glutaraldehyde and genipin, respectively, although activity recovery was better  when genipin was use, reaching up to 81 %. The immobilized keratinase showed  better thermal and pH stabilities compared to the soluble form. The residual  activity of immobilized keratinase remained more than 60 % of its initial  activity after five hydrolytic cycles. The results in this study supported that  glutaraldehyde could be replaced by genipin as an alternative cross-linking eco-friendly  agent for enzyme immobilization","palabras_clave":"Keratinase|Immobilization|Genipin|Chitosan beads|Hair waste"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39441,"idioma_id":4,"titulo":"?Platelet-derived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients?","resumen":"Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology  among women of reproductive age, and is characterized by abnormalities in ovarian  angiogenesis, among other features. Consistent with this association, follicular fluid  (FF) concentration and ovarian expression of vascular endothelial growth factor  (VEGF) are increased in PCOS patients. In this study, we examined the protein levels  of platelet-derived growth factor (PDGF) BB and DD (PDGFBB and PDGFDD),  angiopoietin 1 and 2 (ANGPT1 and ANGPT2), and their soluble receptor sTIE2 in FF  from PCOS and control patients undergoing assisted reproductive techniques. We  also analyzed the effect of FF from PCOS and control patients on tight and adherens  junction protein expression in an endothelial cell line. PDGFBB and PDGFDD were  significantly lower whereas ANGPT1 concentration was significantly higher in FF  from PCOS patients than from control patients. No changes were found in the  concentration of ANGPT2 or sTIE2. Expression of claudin-5 was significantly increased  in endothelial cells incubated for 24 hr in the presence of FF from PCOS  versus from control patients, while vascular-endothelial cadherin, b-catenin, and  zonula occludens 1 expression were unchanged. The changes observed in the levels  ofPDGF isoforms andANGPT1 may prevent VEGF-induced vascular permeability in  the PCOS ovary by regulating endothelial-cell-junction protein levels. Restoring the  levels of angiogenic factors may provide new insights into PCOS treatment and the  prevention of ovarian hyperstimulation syndrome in affected women.","palabras_clave":"Platelet-Derived Growth Factos|PCOS|Follicular Fluid|Angiopoietin1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39442,"idioma_id":4,"titulo":"Plant secondary succession age-related changes in landfills","resumen":"Sanitary landfills are widely used for large-scale disposal of municipal wastes. The material covering the  wastes is diverse in nature and bears propagules of different plant species, which develop spontaneously after  waste disposal stops. The aim of this study was to detect patterns of vegetation secondary succession over the  landfill cells. Along two years, eight samplings were carried out on each of 13 cells from the three active  landfills in Buenos Aires. The relative cover for each plant species and the soil?s mechanic resistance were  registered. Data was analyzed relating the level of vegetation cover and diversity with cell´s age. The  vegetation cover reached 80% after five years, being almost 100% from nine years and afterwards. A decrease  in soil´s mechanic resistance was observed also at 5 years after closure. Regarding the floristic composition,  42% of the herbaceous species were native and 62 % perennials. Cynodon dactylon was dominant in all the  cells. Diversity and species richness were not related to cell age. Even though non-natives dominate, native  species increase their proportion in the older cells. We conclude that the first stages of the plant colonization  on landfill technosols are dominated by non-native species; early successional stages are primarily driven by  the suit of propagules brought in with the soil cover; this driving force eases after 5 to 9 years since closure,  when native plants start to increase their proportion. Soil compaction is likely a limiting factor for plant  colonization during the first few years after closure. All these patterns can be observed after only 23 years of  plant succession on these technosols.  Keywords: landfills, technosols, vegetation cover, diversity, native species","palabras_clave":"LANDFILLS|VEGETATION COVER|DIVERSITY|SOIL MECHANIC RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39443,"idioma_id":4,"titulo":"The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer","resumen":"There is clinical and experimental evidence suggesting that antiprogestins might be used for the treatment of selected breast cancer patients. Our aim was to evaluate the effect of albumin-bound paclitaxel (Nab-paclitaxel) and pegylated doxorubicin liposomes (PEG-LD) in combination with mifepristone (MFP) in experimental breast cancer models expressing different ratios of progesterone receptor (PR) isoforms A and B. We used two antiprogestin-responsive (PRA>PRB) and two resistant (PRA<PRB) murine mammary carcinomas growing in BALB\/c, GFP-BALB\/c or nude mice, along with human T47D-YA and T47D-YB xenografts growing in immunocompromised NSG mice. MFP improved the therapeutic effects of suboptimal doses of Nab-paclitaxel or PEG-LD in murine and human carcinomas with higher levels of PRA than PRB. MFP induced tissue remodeling in PRA-overexpressing tumors, increasing the stromal\/tumor cell ratio and the number of functional vessels. Accordingly, an increase in nanoparticles and drug accumulation was observed in stromal and tumor cells in MFP-treated tumors. We conclude that MFP induces an increase in vessels during tissue remodeling, favoring the selective accumulation of nanoparticles inside the tumors. We propose that antiprogestins have the potential to enhance the efficacy of chemotherapy in breast tumors with a high PRA\/PRB ratio.","palabras_clave":"breast cancer|PR isoforms|doxorubicin|paclitaxel|mifepristone|mammary carcinomas|Nab-paclitaxel|pegylated doxorubicin liposomes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39444,"idioma_id":4,"titulo":"The AIMSS Project I: Bridging the Star Cluster - Galaxy Divide","resumen":"We describe the structural and kinematic properties of the first 28 compact stellar systems discovered by the Archive of Intermediate Mass Stellar Systems (AIMSS) project. This survey identi&#64257;es compact stellar systems in archival HST images of nearby (D &lt; 200 Mpc) galaxies and uses spectroscopic follow-up to confirm their nature (success rate currently &gt; 96%) and to measure their internal&nbsp; kinematics and determine their stellar populations.&nbsp;&nbsp;&nbsp; The objects presented here have e&#8629;ective radii (~6 &lt; Re [pc] &lt; 500) and stellar masses (~2x10^6 &lt; M* \/M0 &lt; 6x10^9 ) spanning the range displayed by massive globular clusters (GCs), ultra compact dwarfs (UCDs) and compact elliptical galaxies (cEs), and they completely fill the gap between star clusters and galaxies. Several ofthe objects have masses and sizes (and hence stellar densities) comparable to those of the prototypical cE, M32, making them the best M32 analogues known. These objects, which are more luminous\/massive than previously discovered UCDs of the same size,further call into question the existence of a tight mass-size trend for compact stellar systems. However, these new objects further strengthen the case for a universal 'zone of avoidance' for dynamically hot old stellar systems in the mass vs size plane.&nbsp;&nbsp;&nbsp; Examination of the luminosity\/mass distribution of our compact stellar systems combined with literature samples, provides further support for a separation of such systems into two types: 1) those formed in-situ, in major star formation events (i.e. massive star clusters), and 2) a second population related to galaxies, either free-&#64258;oating galaxy nuclei\/bulges liberated by the tidal disruption of their hosts or lower mass analogues of classical ellipticals. The relative frequencies of these objects support the suggestion that in general, old UCDs\/cEs more luminous than MV~ -13 are the result of stripping, whilst below this luminosity limit the population is increasingly dominated by massive star clusters.&nbsp;&nbsp;&nbsp;&nbsp; We also see strong indications that the galaxy-type population divides into two groups, which we associate with objects formed by the stripping of nucleated dwarf galaxies (and found amongst the UCDs), and a second more massive population that formed from the stripping of galaxies with bulges or which are a lower mass extensionof the elliptical formation process (the densest UCDs and cEs). Finally, our compact stellar systems are found associated with galaxies in all environments, from isolated galaxies to the densest clusters, demonstrating that the processes responsible for com-pact stellar system formation are not limited to high density environments. ","palabras_clave":"Dwarf Galaxies|Globular clusters|Compact Dwarf Galaxies"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39445,"idioma_id":4,"titulo":"Mapping shallow lakes in a large South American floodplain: A frequency approach on multitemporal Landsat TM\/ETM data","resumen":"We propose a methodology to identify and map shallow lakes (SL) in the Paraná River floodplain, the largest freshwater wetland ecosystem in temperate South America. The presence and number of SL offer various ecosystem services and habitats for wildlife biodiversity. Our approach involved a frequency analysis over a 1987?2010 time series of the Normalized Difference Vegetation Index (NDVI), derived from Landsat 5 and 7 TM\/ETM data. Through descriptive statistics of samples of pixels and field work in different types of SL, we established an NDVI threshold of 0.34 below which we assumed the presence of water in each pixel. The standard deviation of the estimated SL area decreases with the number of images in the analysis, being less than 10% when at least 30 images are used. The mean SL area for the whole period was 112,691 ha (10.9% of the study area). The influence of the hydrological conditions on the resulting SL map was evaluated by analyzing twelve sets of images, which were selected to span the whole period and different time frames according to multiannual dry and wet periods and to relative water level within each period. The Kappa index was then calculated between pairs of resulting SL maps. We compared our maps with the available national and international cartographic documents and with other published maps that used one or a few Landsat images. Landsat images time series provide an accurate spatial and temporal resolution for SL identification in floodplains, particularly in temperate zones with a good provision of cloud free images. The method evaluated in this paper considers the dynamics of SL and reduces the uncertainties of the fuzzy boundaries. Thus, it provides a robust database of SL and its temporal behavior to establish future monitoring programs based on the recent launch of Landsat 8 satellite.","palabras_clave":"Shallow lakes map|Paraná River floodplain|Wetlands|Landsat Time series"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39446,"idioma_id":5,"titulo":"Los derechos sociales y las políticas públicas: una psicología social entre la autoorganización social y el ejercicio de la ciudadanía.","resumen":"Nuestra presentación tiene un doble propósito: exponer la compleja articulación entre las políticas públicas en la Ciudad de Buenos Aires y sus principales tendencias en vivienda y alimentos hasta el año 2011, y analizar las relaciones de las mismas con las prácticas y representaciones de funcionarios y agentes de distintos niveles de responsabildad, respecto de los destinatarios de dichas políticas. La metodología es cualitativa y las principales técnicas usadas son análisis de documentos, entrevistas y estrategias observacionales. El análisis nos permitió identificar una relación paradojal entre el desmantelamiento del estado de bienestar a partir de la recesión económica de los ?90 y las transformaciones de las políticas públicas relativas a la vivienda acorde con los tratados internacionales. En la implementación de dichas políticas detectamos una marcada tensión entre tres tipos de concepciones en los funcionarios y sus respectivos posicionamientos relativos respecto de los beneficiarios, que van desde un fuerte compromiso interaccional a una conceptualización de las comunidades beneficiarias como fuente de riesgo y de naturaleza contracomunitaria.","palabras_clave":"POLÍTICAS PÚBLICAS|VIVIENDAS - ALIMENTOS|REPRESENTACIONES SOCIALES|BENEFICIARIOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39447,"idioma_id":5,"titulo":"Restauración de bosque nativo en un área invadida por tamariscos (Tamarix ramossisima Ledeb.) en el sur de la provincia de Córdoba, Argentina","resumen":"Restauración de bosque nativo en un área invadida por tamariscos Tamarix ramossisima en el sur de la provincia de Córdoba, Argentina.&nbsp;  El hombre produce impactos acumulativos sobre los ecosistemas, siendo las especies exóticas invasoras uno de los más relevantes. Uno de los fines dela restauración ecológica es &nbsp;reparar los ecosistemas para que sean capaces de persistir en ambientes futuros. Este trabajo tiene como objetivo diseñar e implementar técnicas de manejo para la recuperación de ambientes invadidos por tamariscos .T. ramossisima . en el sur de Córdoba (Argentina). Se realizó un ensayo de restauración consistente en el control de tamariscos (tala y aplicación de herbicida), selección y plantación de especies nativas y evaluación del banco de semillas germinable del bosque de tamarisco y del bosque nativo de referencia. Se delimitaron doce parcelas donde se aplicaron cuatro tratamientos: 1) testigo; 2) control de tamariscos; 3) control y plantación de especies nativas; y 4) control, plantación de especies nativas y trasplante de banco de semillas. Se monitoreo durante 20 meses las variables rebrote de tamarisco, riqueza de la comunidad, cobertura de las especies nativas, emergencia y supervivencia de las plántulas del banco de semillas. El 89% de los individuos de tamarisco no rebrotaron. Las especies seleccionadas fueron Lycium boerhaviifolium, Vachellia caven, Schinus fasciculatus, Celtis ehrembergiana y Atriplex undulata. El banco de semillas no aporto nuevos individuos de especies nativas. Se destaca la importancia de la revegetación con especies leñosas nativas luego del control de tamariscos como estrategia para incrementar la biodiversidad.               ","palabras_clave":"especies nativas|revegetacion|invasiones biológicas|banco de semillas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39448,"idioma_id":4,"titulo":"Homogeneous Ricci solitons in low dimensions","resumen":"In this article we classify expanding homogeneous Ricci solitons up to dimension $5$, according to their presentation as homogeneous spaces. We obtain that they are all isometric to solvsolitons, and this in particular implies that the generalized Alekseevskii conjecture holds in these dimensions. In addition, we prove that the conjecture holds in dimension $6$ provided the transitive group is not semisimple.","palabras_clave":"Homogeneous Riemannian manifolds|Ricci solitons|Einstein homogeneous metrics|Low dimensional classification"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39449,"idioma_id":5,"titulo":"Covariación ontogénica en el endocráneo de Pan troglodytes","resumen":"Diversos estudios proponen que el neurocráneo en Homo sapiens es una estructura integrada y que la morfología de la bóveda y la base se asocia con modificaciones del cerebro. En este estudio se evaluó la covariación ontogénica en el endocráneo de Pan troglodytes, otro primate altamente encefalizado. Se analizaron 52 reconstrucciones 3D derivadas de tomografías computadas de individuos adultos y subadultos. Una vez segmentadas las cavidades endocraneanas, se relevaron 27 landmarks. A partir de su configuración, se obtuvieron el tamaño del centroide y las coordenadas de Procrustes y se realizó Análisis de Componentes Principales, regresión, correlación, ANOVA y análisis F de Goodall a fin de evaluar los cambios de tamaño y forma respecto de la edad y las alometrías. Los cambios en forma están fuertemente integrados y se producen hasta etapas tardías de la ontogenia: elongación de la bóveda y la base, distanciamiento entre el foramen magnun y la placa cribiforme, retroflexión del ángulo basicraneano y descenso de los polos temporales. A partir del análisis PLS se observó que los cambios en la base y la bóveda covarían, pero cuando se ajustó el efecto alométrico, dicha covariación se hizo no significativa, tal como ocurre en Homo sapiens. Esto sugiere que el aumento ontogénico del volumen endocraneano -en relación con el crecimiento cerebral- constituye un factor común de integración entre la bóveda y la base en ambas especies. Sin embargo, es probable que en el chimpancé se sume la influencia de distintas estructuras faciales que promuevan variación y covariación en el endocráneo.","palabras_clave":"chimpancé|tomografía computada|integración|cerebro"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39450,"idioma_id":4,"titulo":"Expression and purification of recombinant feline interferon in the baculovirus-insect larvae system","resumen":"Feline interferons (FeIFNs) are cytokines with antiviral, antitumor and immunomodulatory functions used as therapeutic agents in a variety of veterinary diseases. In this work, FeIFN-&#945;7 and FeIFN-&#945;7xArg containing eight residues of arginine were expressed in Sf9 cells and insect larvae. At 4 days post-infection (dpi), the concentrations of FeIFN-&#945;7 and FeIFN-&#945;7xArg in suspension culture were (1.28 ± 0.15) × 106 U ml-1 and (1.3 ± 0.2) × 106 U ml-1respectively. The maximum expression levels of FeIFN-&#945;7 and FeIFN-&#945;7xArg were (3.7 ± 0.2) × 106 U ml -1 and (3.5 ± 0.4) × 106 U ml-1 at 2 dpi in Rachiplusia nu larvae and (1.1 ± 0.2) × 106 U ml-1 and (1.0 ± 0.15) × 106 U ml-1 at 5 dpi in Spodoptera frugiperda larvae respectively. R. nu was a better host for FeIFN-&#945;7 and FeIFN-&#945;7xArg expression. The 8xArg tag did not affect the biological activity of FeIFN-&#945;7 and was useful to promote the FeIFN-&#945;7xArg adsorption on ion exchange chromatography (IEC), allowing its purification in a single step from supernatant culture and R. nu larvae. FeIFN-&#945;7xArg was purified from the larval extract with a yield of 70% and a purification factor of 25 free of viruses. We conclude that R. nu larvae are new low-cost hosts for the expression of recombinant FeIFN-&#945;7. © 2014 Elsevier Ltd.","palabras_clave":"Baculovirus Expression|Feline interferon|Ion exchange chromatography|Polyarginine tag; Purification"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39451,"idioma_id":4,"titulo":"Synergism of arsenic trioxide and MG132 in Raji cells attained by targeting BNIP3, autophagy, and mitochondria with low doses of valproic acid and vincristine","resumen":"Abstract  We previously demonstrated that arsenic trioxide (ATO) and proteasome inhibitor MG132 synergistically induced cell death in promonocytic leukaemia cell line U937 but were antagonistic in Burkitt?s lymphoma cell line Raji. Here we explore the role of autophagy, expression of BNIP3, and mitochondrial mass, in determining whether ATO and MG132 interaction can be shifted from antagonism to synergism in Raji cells. Treatment with ATO + MG132 increased the percentage of cells with collapsed mitochondrial membrane potential (MMP) in U937 cells, but had no effect in Raji cells. Mitochondria were found in cytoplasmic marginal location in U937 cells but at perinuclear location in Raji cells. ATO + MG132 increased mitochondrial mass in U937 cells but decreased it in Raji cells, while autophagy was increased in both cell lines. BNIP3 was expressed in U937 cells at cytoplasmic marginal locations and was hardly detected in Raji cells. Histone deacetylase (HDAC) inhibitor valproic acid (VPA) increased expression of BNIP3 in Raji cells at perinuclear locations. However antagonism between ATO and MG132 was increased in the presence of low doses of VPA. Addition of vincristine (VCR) blocked autophagy, while VPA + VCR treatment of Raji cells at sub-cytotoxic doses caused BNIP3 and mitochondria to redistribute to cytoplasmic peripheral location and increased mitochondrial mass. ATO + MG132 in the presence of subcytotoxic doses of VPA + VCR caused collapse of MMP in Raji cells, while interaction between ATO and MG132 shifted from antagonism to synergism. We conclude that synergism between ATO and MG132 was attained in Raji cells by disruption of the perinuclear mitochondrial cluster, blockage of selective autophagy of mitochondria (mitophagy) by VCR, increased mitochondrial mass, and upregulation of BNIP3 by VPA.","palabras_clave":"SYNERGISM|BNIP3|MITOCHONDRIA|MITOPHAGY|AUTOPHAGY|TARGETED COMBINED|THERAPIES|ARSENIC TRIOXIDE|MG132|VALPROIC ACID|BURKITT´SLYMPHOMA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39452,"idioma_id":4,"titulo":"Mercury distribution in a toposequence of sub-Antarctic forest soils of Tierra del Fuego (Argentina) as consequence of the prevailing soil processes","resumen":"The total content, distribution and assessment of Hg sources in five soils of a toposequence of sub-Antarctic forest soils in Tierra del Fuego were explained as a combination of pedogenetic processes and the interactions between Hg and the soil compounds. The soils of the toposequence were mainly podzols and podzolic soils, strongly acidic (water pH b 5.0), organic matter rich in O horizons (239?444 g kg&#8722;1) and non-crystalline compounds dominate Al and Fe distribution. The total Hg (HgT) values ranged between 12 and 375 ng g&#8722;1 and diminished with soil depth although the secondary peaks of the HgT were observed in illuvial (Bhs or Bs) or buried A horizons. Thetotal Hg was significantly correlated to the total contents of C, N and S (r N 0.71) and to the contents of the non-crystalline Al and Fe compounds (0.44?0.71), whereas the Hg\/C ratio increases with soil depth up to values of 11.3 &#956;g Hg g&#8722;1 C. Exogenic Hg, i.e. Hg deposited from the atmosphere (HgExo), constitutes over 87% of the HgT in the O and A horizons, whilst lithogenic Hg (HgLit) is 36% of the average HgT. Podzolization seems to control the distribution of the HgT in the mid-slope and upslope soils (P480, P590, P630), as suggested by the HgT peaks in the Bhs or Bs horizons, where illuviated organic matter and non-crystalline Al and Fe&nbsp; compounds favour Hg retention. In the downslope soils (P340 and P220), both podzolization andpolycyclism (that result in soils formed by two or more different and contrasting processes derived from a substantial change in soil formations factors, that lead to the accumulation of features over their lifetime), seem to influence the HgT depth pattern in light of the high values observed in the A and Bhs horizons of the buried soils. The significant correlation between the Hg\/C and Cp\/C ratios strengthens the efficiency of humified organic matter to complex Hg,whereas the peaks of the Hg\/C ratio in the Bhs and Bs horizons also indicate that Al and Fe compounds are also involved in Hg retention. Polycyclic events, i.e. those contrasting soil processes that lead to different chemical and morphological signatures within the soil profile, could justify high HgLit values in the deeper horizons of the downslope soils,whilst the peaks of HgExo in the Bhs or Bs horizons could be considered to be a consequence of Hg mobilization and the subsequent retention by Al and Fe compounds during podzolization which is supported by the significant correlations of thesesoil compounds with HgExo. Environmentally, illuvial horizons and buried A horizons could act as a safety mechanism delaying the arrival of Hg to stream waters.","palabras_clave":"Sub-Antarctic forest soils|mercury|podzolization and polycyclism|non-crystalline Al and Fe compounds"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39453,"idioma_id":4,"titulo":"Morphology and histology of the uropygial gland in Antarctic birds: relationship with their contact with the aquatic environment?","resumen":"The uropygial gland is morphologically different in diverse bird species. This gland was macroscopically and  microscopically examined in penguins, storm petrels and skuas. In all the studied species, the gland showed a connective  tissue capsule and one papilla.Anegative relationship was observed between the relative glandular mass and the body mass,  being highest in petrels (small glands) and lowest in penguins (large glands). Birds that spend much time in water (penguins)  have gland characteristics related to a continuous, but not stored, secretion, such as straight adenomers, the presence of  abundant elastic fibres in the connective tissue and the absence of a primary storage chamber. Instead, birds that have less  contact with water (storm petrels) have a gland with much more tortuous adenomers and a small primary storage chamber.  The secretory cells showed a positivePASreaction in all the glandular zones. Therefore, no differences could be seen between  the sebaceous and glucogenic zones, as proposed in other birds. These results allow the conclusion that, in aquatic birds, there  is no connection between the relative mass of the uropygial gland and the time in contact with water, though the differences  found in the histological structure could be related to a different contact with the aquatic environment.","palabras_clave":"avian gland|preen gland|seabirds"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39454,"idioma_id":4,"titulo":"Helminth parasites of the European Starling (Sturnus vulgaris) (Aves, Sturnidae), an invasive bird in Argentina","resumen":"The aim of this work is to contribute to the knowledge of gastrointestinal parasites of the European Starling Sturnus vulgaris, an invasive bird from Argentina. Seventy six birds were collected during the spring of 2007 and examined for helminths. Six parasite species were found: one Digenea species of the Echinostoma revolutum ?group?, four Nematoda species (Synhimantus nasuta, Microtetrameres sp., Pterothominx exilis and Ornithocapillaria ovopunctata), and one Acanthocephalan (Plagiorhynchus cylindraceus). All species found in this work were registered in Eurasia and\/or North America previously, although present reports enlarge their geographical distribution. As expected in an invasive host, the parasite community show lower richness (n=6) than those observed in their native area (79 and 35 in the Eurasia and North America respectively).","palabras_clave":"STURNUS VULGARIS|ARGENTINA|ESTORNINO PINTO|ECHINOSTOMA REVOLUTUM|SYNHIMANTUS NASUTA|MICROTETRAMERES|PTEROTHOMINX EXILIS|ORNITHOCAPILLARIA OVOPUNCTATA|PLAGIORHYNCHUS CYLINDRACEUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39455,"idioma_id":4,"titulo":"Pleiotropic effect of AccD5 and AccE5 depletion in acyl-coenzyme A carboxylase activity and in lipid biosynthesis in mycobacteria","resumen":"Mycobacteria contain a large variety of fatty acids which are used for the biosynthesis of several complex cell wall lipids that have been implicated in the ability of the organism to resist host defenses. The building blocks for the biosynthesis of all these lipids are provided by a fairly complex set of acyl-CoA carboxylases (ACCases) whose subunit composition and roles within these organisms have not yet been clearly established. Previous biochemical and structural studies provided strong evidences that ACCase 5 from Mycobacterium tuberculosis is formed by the AccA3, AccD5 and AccE5 subunits and that this enzyme complex carboxylates acetyl-CoA and propionyl-CoA with a clear substrate preference for the latest. In this work we used a genetic approach to unambiguously demonstrate that the products of both accD5 and accE5 genes are essential for the viability of Mycobacterium smegmatis. By obtaining a conditional mutant on the accD5-accE5 operon, we also demonstrated that the main physiological role of this enzyme complex was to provide the substrates for fatty acid and mycolic acid biosynthesis. Furthermore, enzymatic and biochemical analysis of the conditional mutant provided strong evidences supporting the notion that AccD5 and\/or AccE5 have an additional role in the carboxylation of long chain acyl-CoA prior to mycolic acid condensation. These studies represent a significant step towards a better understanding of the roles of ACCases in mycobacteria and confirm ACCase 5 as an interesting target for the development of new antimycobacterial drugs.","palabras_clave":"MYCOBACTERIUM|MYCOLIC ACID|ACYL-COA CARBOXYLASE|MUTANT ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39456,"idioma_id":4,"titulo":"Arbuscular mycorrhizal fungi alleviate oxidative stress in pomegranate plants growing under different irrigation conditions","resumen":"Drought greatly affects the growth and development of plants. This stressful condition can trigger an increase in reactive oxygen species (ROS) production that, in turn, can induce cellular, anatomical, and morphological changes that improve drought tolerance. A strain of arbuscular mycorrhizal fungi (AMF) is considered efficient when it colonizes roots quickly and extensively, absorbs and transfers nutrients to the plant host, promotes soil aggregation, and protects the host against disease. We evaluated the effect of inoculation of two strains of the AMF Rhizophagus intraradices (N.C. Schenck & G.S. Smith) C. Walker & A. Schüßler (GA5 and GC2) on pomegranate plants (Punica granatum L.) under two irrigation conditions. The response to oxidative stress depended on many factors, including the organism tissue and the degree of stress. Our study showed that, in most cases, mycorrhizal plants increased antioxidant defenses, such as the ROS-scavenging enzymes superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) in shoots under both irrigation levels, whereas the response for roots was ambiguous. AMF inoculation maintained the levels of malondialdehyde (MDA), probably by rapidly increasing antioxidant defenses and preventing lipid damage. We show that early AMF inoculation (particularly with the GC2 strain) in pomegranate propagation protects plants against abiotic stress.","palabras_clave":"ARBUSCULAR MYCORRHIZAL FUNGI|POMEGRANATE|CATALASE|ASCORBATE PEROXIDASE|GLUTHATIONE REDUCTASE|SUPEROXIDE DISMUTASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39457,"idioma_id":4,"titulo":"Postcranial anatomy of the early notoungulate Allalmeia atalaensis from the Eocene of Argentina","resumen":"We redescribe and interpret the postcranial elements of Allalmeia atalaensis Rusconi, found in the Divisadero Largo Formation, Mendoza,  Argentina. Allalmeia is one of the few basal notoungulates with preserved postcranial remains. Rusconi initially documented a skull, several  vertebrae and part of the appendicular skeleton but these specimens were subsequently lost. Recently though, distal components of the holotype  humeri, the proximal portion of the right femur, several broken diaphyses and most of the left and right pes (MCNAM-PV 507), were relocated.  Preparation of this material has revealed new details, especially from the plantar side of the feet. The calcaneum has a distal peroneal process with marked rugosity in the lateral end, a well-developed calcaneal plantar tubercle and a large sustentaculum tali. The naviculars exhibit a  well-developed medial tuberosity and slightly contact the calcaneum on the dorsal side, a condition called a ?reverse alternating tarsus?. The  disposition and morphology of the cuneiforms are similar to those of more recent typotheres and the archaic ungulate Tetraclaenodon puercensis.  The phalangeal rows are oblique to each other, as in some extant digitigrade mammals. The ungual phalanges are claw-like suggesting that they might have borne claws. Long bones are gracile in comparison with other notoungulates, but with well-developed muscle origins and insertions. The use of body-mass allometric equations and a comparison with extant analogues suggests that Allalmeia was a small, generalized, digitigrade animal. An estimated body mass of approximately 3 kg is consistent with oldfieldthomasiids and archaic ungulates.","palabras_clave":"Notoungulata|Eocene|Mendoza"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39458,"idioma_id":5,"titulo":"Primer registro de Biremis circumtexta (Bacillariophyceae) para Tucumán, Argentina","resumen":"En el presente trabajo se da a conocer el primer registro de Biremis circumtexta (Bacillariophyceae) para Tucumán, Argentina y de datos fisicoquímicos del ambiente lótico estudiado. Se amplía el área de distribución de esta especie para Argentina.","palabras_clave":"BACILLARIOPHYCEAE|BIREMIS CIRCUMTEXTA |TUCUMÁN|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39459,"idioma_id":4,"titulo":"Surface coverage dictates the surface bio-activity of D-amino acid oxidase","resumen":"This work presents a systematic study on the relationship between the adsorptionmechanism and the surface bio-activity of D-amino acid oxidase (pkDAAO). Thisrational approach is based on measuring the characteristic filling and relaxation timesunder different experimental conditions. With such a goal, real-time adsorptiondesorptionexperiments at different degrees of surface coverage were performed tuningthe electrostatic and hydrophobic interactions by changing the pH condition for theadsorption and the substrate properties (silica or gold). Surface bio-activity wasmeasured in situ by amperometry using the bio-functional surface as the workingelectrode and ex situ by spectrophotometry. On both solid substrates, pkDAAOadsorption is a transport-controlled process, even under unfavorable electrostaticinteractions (charged protein and substrate with the same sign) due to the highpercentage of basic amino acids in the enzyme. On silica, the relaxation step iselectrostatic in nature and occurs in the same time-scale as filling the surface when thesubstrate and the enzyme are oppositely charged at low surface coverage. Underunfavorable electrostatic conditions, the relaxation (if any) occurs at long time.Accordingly, the bio-activity of the native pkDAAO is preserved at any surfacecoverage. On gold, this step is driven by hydrophobic interactions (pH-independent)and the surface bio-activity is highly dependent on the degree of surface coverage.Under these conditions, the surface bio-activity is preserved only at high surfacescoverage. Our results clearly indicate that pKDAAO bio-functionalized surfaces cannotbe coupled to ampereometry because the analyte interferes the electrochemical signal.However, this simple bio-functionalized strategy can be joined to other detectionmethods.","palabras_clave":"adsorption|filling time|surface denaturing|DAAO|surface relaxation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39460,"idioma_id":4,"titulo":"An Early Cretaceous astropectinid (Echinodermata, Asteroidea) from Patagonia (Argentina): a new species and the oldest record of the family for the Southern Hemisphere","resumen":"Asterozoans are free living, star-shaped echinoderms which are important components of benthic marine faunas worldwide. Their fossil record is, however, poor and fragmentary, probably due to dissarticulation of ossicles. In particular, fossil asteroids are infrequent in South America. A new species of starfish is reported from the early Valanginian of the Mulichinco Formation, Neuquén Basin, in the context of a shallow-water, storm-dominated shoreface environment. The specimen belongs to the Astropectinidae, and was assigned to a new species within the genus Tethyaster Sladen, T. antares sp. nov., characterized by a R:r ratio of 2.43:1, rectangular marginals wider in the interbrachial angles, inferomarginals (28 pairs along a median arc) with slightly convex profile and flat spines (one per ossicle in the interbrachials and two per ossicle in the arms). Both the sedimentologic features of the bearing bed, and the taphonomic signature point to a rapid burial. Considering the presence of well-developed fascioles, it is likely that the specimen was already half buried at the beginning of its taphonomic pathway. This record represents the oldest finding of Astropectinidae in the Southern Hemisphere and the first record of the genus Tethyaster for the Lower Cretaceous of South America.&nbsp;","palabras_clave":"Astropectinidae|Tethyaster|Early Cretaceous|Patagonia|Mulichinco Formation|Neuquén Basin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39461,"idioma_id":4,"titulo":"Bone modeling patterns and morphometric craniofacial variation in individuals from two prehistoric human populations from Argentina","resumen":"Native human populations from South America display high levels of craniofacial variation encompassing gracile and robust skulls. Nevertheless, the processes of bone modeling by which morphological variation among populations were attained, remain poorly understood. Here we analyze the relationship between patterns of bone formation and resorption and morphometric variation in the upper face of adults belonging to farmers and hunter-gatherers from northwestern and south Argentina. Our analyses reveal a common pattern of bone modeling of the malar bone characterized by the presence of formation areas. Thus, the larger size and greater development of malar bone exhibited by hunter-gatherers would be linked to a greater magnitude of bone formation activity. Conversely, the glabella and the superciliary arch presented both formation and resorption areas with a variable distribution among individuals. In the extreme corresponding to more robust morphologies, the great development of the glabella is related to the presence of large formation fields, both in the upper region and toward the frontonasal suture. The less robust morphologies show resorption fields at the upper margin of the glabella, which would contribute to the weaker development of this region. The superciliary arch showed a complex relationship between its morphometric and histological variation; the individuals located at both extremes of the shape space presented large resorption areas located on its upper margin. Overall, our results show the existence of intraspecific variation in the patterns of bone modeling in the human upper face.","palabras_clave":"bone formation and resorption|geometric morphometric|human face"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39462,"idioma_id":4,"titulo":"Canarypox virus expressing infectious bursal disease VP2 protein as immunogen for chickens","resumen":"Canarypox viruses (CNPV) carrying the coding sequence of VP2 protein from infectious bursal disease virus (IBDV) were obtained. These viruses were able to express VP2 protein in vitro and to induce IBDV-neutralizing antibodies when inoculated in specific pathogen-free chickens demonstrating that CNPV platform is usefulness to develop immunogens for chickens.","palabras_clave":"canarypox virus|viral vector |IBDV|VP2 protein"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39463,"idioma_id":4,"titulo":"Damping Micromechanisms for Bones above Room Temperature","resumen":"The wide damping maximum which is reported to appear in bones, involvingbothcortical and cancellous parts, between around 280 K and 420 K; has beendetermined to be acomposition of different processes taking place at different temperaturesin cancellous and corticalparts. In fact, in the present work the mechanical response of cow ribsbones has been analysed bycoupling mechanical spectroscopy, differential scanning calorimetry,thermogravimetry andscanning electron microscopy studies. Cancellous part develops two dampingmaxima at around 320K and 350 K. Cortical part exhibits a wide maximum in damping betweenaround 310 K and 410 Kand another damping relaxation between 390 K and 410 K. Thephysical-chemical driving forcegiving rise to the above relaxation processes are discussed.","palabras_clave":"BONE|MECHANICAL SPECTROSCOPY|DIFFERENTIAL SCANNING CALORIMETRY|THERMOGRAVIMETRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39464,"idioma_id":4,"titulo":"Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets","resumen":"BACKGROUND:Familial platelet disorder with a predisposition to acute myelogenous leukemia (FPD\/AML) is an inherited platelet disorder caused by a germline RUNX1 mutation and characterized by thrombocytopenia, a platelet function defect, and leukemia predisposition. The mechanisms underlying FPD\/AML platelet dysfunction remain incompletely clarified. We aimed to determine the contribution of platelet structural abnormalities and defective activation pathways to the platelet phenotype. In addition, by using a candidate gene approach, we sought to identify potential RUNX1-regulated genes involved in these defects.METHODS:Lumiaggregometry, &#945;-granule and dense granule content and release, platelet ultrastructure, &#945;IIb &#946;3 integrin activation and outside-in signaling were assessed in members of one FPD\/AML pedigree. Expression levels of candidate genes were measured and luciferase reporter assays and chromatin immunoprecipitation were performed to study NF-E2 regulation by RUNX1.RESULTS:A severe decrease in platelet aggregation, defective &#945;IIb &#946;3 integrin activation and combined &#945;&#948; storage pool deficiency were found. However, whereas the number of dense granules was markedly reduced, &#945;-granule content was heterogeneous. A trend towards decreased platelet spreading was found, and &#946;3 integrin phosphorylation was impaired, reflecting altered outside-in signaling. A decrease in the level of transcription factor p45 NF-E2 was shown in platelet RNA and lysates, and other deregulated genes included RAB27B and MYL9. RUNX1 was shown to bind to the NF-E2 promoter in primary megakaryocytes, and wild-type RUNX1, but not FPD\/AML mutants, was able to activate NF-E2 expression.CONCLUSIONS:The FPD\/AML platelet function defect represents a complex trait, and RUNX1 orchestrates platelet function by regulating diverse aspects of this process. This study highlights the RUNX1 target NF-E2 as part of the molecular network by which RUNX1 regulates platelet biogenesis and function.","palabras_clave":"FPD\/AML|NF-E2 transcription factor|RUNX1 protein| Rab27B protein, human"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39465,"idioma_id":4,"titulo":"Efficacy and safety of long term entecavir in chronic hepatitis B treatment naïve patients in clinical practice","resumen":"BACKGROUND AND AIMS:Entecavir (ETV) is effective and safe in patients with chronic hepatitis B in the short term, but its long term efficacy and safety has not been established.MATERIAL AND METHODS:We evaluated HBV DNA clearance, HBeAg\/antiHBe and HBsAg\/antiHBs seroconversion rates in HBeAg-positive and negative NUC naïve HBV patients treated with ETV for more than 6 months, and predictors of response.RESULTS:A hundred and sixty nine consecutive patients were treated with ETV for a median of 181 weeks. 61% were HBeAg positive, 23% were cirrhotics, and mean HBV-DNA levels were 6,88 ± 1,74 log10 IU\/mL. Overall, 156 (92%) patients became HBV DNA undetectable, 92 (88%) HBeAg positive and 64 (98%) HBeAg negative patients. Seventy four (71%) patients cleared HBeAg after a median of 48 weeks of treatment, 23 (14%) patients cleared HBsAg (19 HBeAg positive and 4 HBeAg negative, p 0.025) after a median of 96 weeks of treatment, and 22 (13%) patients developed protective titers of anti-HBs. At the end of the study, 35 (20%) patients had discontinued therapy: 33 HBeAg positive and 2 HBeAg negative; 9 of them (26%) developed virological relapse after a median of 48 weeks of stopping treatment. None of the patients had primary non response and one patient developed breakthrough. Two patients developed HCC, three underwent liver transplantation and 3 deaths were attributable to liver-related events. No serious adverse events were reported.CONCLUSION:Long term ETV treatment showed high virological response rates, and a favorable safety profile for NUC-naive HBeAg-positive and negative patients treated in clinical practice.","palabras_clave":"CHRONIC HEPATITIS B|EFFICACY|ENTECAVIR|SAFETY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39466,"idioma_id":4,"titulo":"The effect of dichlorophen binding to silica nanoparticles on its photosensitized degradation in water","resumen":"The production of dichlorophen (2,2´-methylenebis(4-chlorophenol), DCP) and its use as an anthelmintic and in pesticide products result in its direct release to the environment.&nbsp; To the purpose of modeling the possible photodegradation routes of DCP sorbed on sediments or suspended particles, the synthesis and characterization of silica nanoparticles modified with DCP (NP-DCP) is reported. The reactivity of NP-DCP with the excited states of riboflavin, a sensitizer usually present in natural waters, and with singlet oxygen were investigated. Comparison of the kinetic results obtained here to those previously reported for irradiated aqueous solutions of DCP allowed the discussion of the effect of adsorption of the pesticide on its photodegradation.We show with the aid of computer simulations that in natural waters the relevance of the different photodegradation routes dichlorophen is very much affected by attachment to sediments.","palabras_clave":"DICHLOROPHEN|PHOTODEGRADATION|SILICA NANOPARTICLES|NATURAL WATERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39467,"idioma_id":4,"titulo":"Application of two bacterial strains for wastewater bioremediation and assessment of phenolics biodegradation","resumen":"The use of native bacteria is a useful strategy to decontaminate industrial effluents. In this work, two bacterial strains isolated from polluted environments constitutes a promising alternative since they were able to remove several phenolic compounds not only from synthetic solutions but also from effluents derived from a chemical industry and a tannery which are complex matrices. Acinetobacter sp. RTE1.4 showed ability to completely remove 2-methoxyphenol (1000 mg\/L) while Rhodococcus sp. CS1 not only degrade the same concentration of this compound but also removed 4- chlorophenol, 2,4-dichlorophenol and pentachlorophenol with high efficiency. Moreover, both bacteria degraded phenols naturally present or even exogenously added at high concentrations in effluents from the chemical industry and a tannery in short time (up to 5 d). In addition, a significant reduction of biological oxygen demand and chemical oxygen demand values was achieved after 7 d of treatment for both effluents using Acinetobacter sp. RTE1.4 and Rhodococcus sp. CS1, respectively. These results showed that Acinetobacter sp. RTE1.4 and Rhodococcus sp. CS1 might be considered as useful biotechnological tools for an efficient treatment of different effluents, since they showed wide versatility to detoxify these complex matrices, even supplemented with high phenol concentrations.","palabras_clave":"WASTEWATER|BIOTREATMENT|PHENOLIC COMPOUNDS|BACTERIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39468,"idioma_id":4,"titulo":"Magnetic parameters and their palaeoclimatic implications ? the sediment record of the last 15,500 cal. BP from Laguna Potrok Aike (Argentina)","resumen":"Lake sediments are excellent sources of palaeoenvironmental and palaeoclimatic infor mation because t hey provide continuous and high-resolution r ecords. South America is of par ticular interest because i t i s t he only l andmass t hat stretches southward i nto t he Paci&#64257;c and Atlantic Oceans towards Antarctica. The aim of this study is to explore t he relationship of magnetic parameters with elemental and palaeobiological data of Laguna Potrok Aike to develop a model of lake-level changes and related hydrological and climatic &#64258;uctuations. M agnetic measurements were perfor med on subsamples from 15 500 cal. BP t o t he present, and associated rock magnetic parameters were calculated to infer magnetic mineralogy, concentration and g r ain size. According to the model, parameters dependent on magnetic concentration and g r ain s ize are directly related t o l ake-level changes. During dr y periods, t he remanent coercivity displays high values, whereas the propor tion of magnetite is relatively low. Low percentages of g r eigite are obser ved, indicating t hat the water of the l ake was strati&#64257;ed at least f our times during t he studied period, at approximately 10 300, 8900, 8500 and 8300 cal. BP. The preser vation of g r eigite by inhibiting its complete t ransfor mation i nto pyrite is associated with a r apid b urial that occurs with high sedimentation r ates. Ther mal s trati&#64257;cation could be caused by a s light cooling i n t he area triggered by a weakening of the Westerlies and\/or low activity of the s un, sum t o t he effect of a &#64258;ood of melt water i n t he Nor t h Atlantic.","palabras_clave":"PALEOCLIMATE|MODELLING|ROCK AND MINERAL MAGNETISM|SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39469,"idioma_id":5,"titulo":"Las posturas oscilantes de una centenaria corporación vitivinícola frente a la regulación de la industria. Mendoza 1930-1955","resumen":"Las regulaciones a la industria vitivinícola de Mendoza tuvieron en el periodo analizado distintos niveles de tolerancia que se expresaron en las contradicciones del discurso del Centro Vitivinícola Nacional, longeva corporación empresaria, que osciló entre las preocupaciones por la rentabilidad del negocio vitivinícola y los avances de la libertad de mercado. Este juego entre políticas públicas y corporaciones empresarias, es, precisamente, el tema de esta investigación que se centra entre 1930 y 1955, año de caída del primer peronismo.  Las disposiciones iniciales postergaron las mejoras en el proceso productivo y contaron con el apoyo del Centro Vitivinícola Nacional, que, sin embargo, años más tarde, con corta memoria, olvidó el reclamado apoyo del estado y se pronunció contra lo que consideró políticas totalitarias.","palabras_clave":"VITIVINICULTURA|REGULACIÓN ESTATAL|CRISIS|PERONISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39470,"idioma_id":4,"titulo":"NLP-Based Faceted Search: Experience in the Development of a Science and Technology Search Engine","resumen":"An appropriate promotion, distribution and dissemination of scientific, artistic and technology developments can foster the collaboration between a country´s productive and academic sectors. The purpose of this paper is to present a novel search engine aiming at helping people to access Science and Technology advances, researchers and institutions working in specific areas of research. Our search engine first collects information disseminated on the Web in academic institution sites and in researchers personal homepages. Then, after intensive text processing, it summarizes the information in an enriched and user-friendly presentation oriented to non-expert users. Stable performance and an acceptable level of effectiveness for automatic named entities recognition indicate the potential of our approach for bridging the gap between the heterogeneous and unstructured information available on the Web about the research and development advances in a country and the innovation required by the productive sectors.","palabras_clave":"VERTICAL SEARCH ENGINES|FACETED SEARCH|NAMED ENTITIES RECOGNITION|NATURAL LANGUAGE PROCESSING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39471,"idioma_id":5,"titulo":"Depuración de efluentes textiles mediante la utilización de técnicas fisicoquímicas y biológicas","resumen":"Existen distintos tipos de matrices fisicoquímicas y biológicas, que pueden depurar aguas residuales de industrias textiles. Las industrias textiles tienen un importante desarrollo en el partido de Luján y algunas de ellas vierten sus efluentes a pequeños cuerpos de agua causándoles gran impacto nocivo.  Estos efluentes suelen contener alta coloración, conductividad y temperatura, elevada concentración de metales pesados como el cadmio, y altas concentraciones de fosfatos y materia orgánica. En este estudio, se trabajó principalmente en ensayos de laboratorio que permitieron comparar la capacidad de eliminación de sustancias por parte de apatitas (matriz física), biofilm (matriz biológica autótrofa) y micelio de hongos (matriz biológica heterotrófica), en forma individual.  Se realizaron experimentos que permitieron cuantificar la interacción de la hidroxiapatita (CaHap) con Cd, a partir de experimentos batch, en un amplio rango de concentraciones. Los resultados obtenidos demuestran que la CaHap es un excelente absorbente de metales pesados, por lo que su empleo para la depuración de efluentes textiles es promisorio.   También se obtuvieron buenos resultados en la decoloración realizada por ambos tipos de matrices biológicas en ensayos de laboratorio. Se considera prometedora su posible combinación, así como una puesta a punto adecuada de los distintos sistemas, para evaluar los rendimientos de captación y\/o eliminación de sustancias de cada uno de ellos así como la posibilidad de utilizarlos en diseños de estaciones de depuración ya sea en forma individual o en serie.","palabras_clave":"Efluentes Textiles|Depuración|Matrices fisicoquímicas|Matrices biológicas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39472,"idioma_id":5,"titulo":"Condicionantes ambientales de comunidades de foraminiferos bentonicos durante el Pleistoceno medio en el Atlántico Sudoccidental","resumen":"El Océano Atlántico Sur es clave en la distribución de masas de agua profunda hacia otros océanos. Dado el papel que juega la circulación termohalina en el clima, el reconocimiento de variaciones en su distribución durante los ciclos glaciales\/interglaciales reviste gran interés. Los foraminíferos bentónicos son utilizados como herramientas de reconstrucción paleoceanográfica, y la existencia de especies asociadas a masas de agua fue utilizada para definir cambios en la circulación oceánica profunda. Sin embargo, la relación entre foraminíferos bentónicos y masas de agua es controversial. Con el objetivo de determinar si las asociaciones de foraminíferos bentónicos reflejan la distribución de las masas de agua profunda durante un evento glacial del  Pleistoceno Medio, se analizó un testigo ubicado en el límite entre dos masas de agua profunda: la North Atlantic Deep Water y la Circumpolar Deep Water. En las asociaciones se hallaron especies consideradas indicadoras de ambas masas de agua, aunque algunas especies asociadas a la Circumpolar Deep Water presentan abundancias relativas mayores, siendo Uvigerina peregrina dominante en ciertos niveles. Sin embargo, la escasa abundancia de Globocassidulina subglobosa, asociada a la Circumpolar Deep Water, y la constancia en el porcentaje de especies consideradas indicadoras de la North Atlantic Deep Water impiden atribuir la dominancia de Uvigerina peregrina a una mayor influencia de la Circumpolar Deep Water. El hecho de que esta especie está asociada a flujos elevados de materia orgánica y que su mayor dominancia coincida  con aumentos en la abundancia de Globigerina bulloides indica que la productividad superficial y no la distribución de las masas de agua determinaron la estructuración de las asociaciones de foraminíferos bentónicos en el talud norbonaerense.","palabras_clave":"Foraminiferos bentónicos|Masas de agua|Productividad primaria|Océano Atlántico Sudoccidental"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39473,"idioma_id":5,"titulo":"Momentos Estocásticos de orden superior  y la estimación de la volatilidad  implícta:  aplicación de la expansión de Edgeworth  y el modelo de Black-Scholes","resumen":"Resumen                                         El documento utiliza la expansión de Edgeworth en el modelo de Black-Scholes para estimar la volatilidad implícita y el impacto en el precio de la opción de los momentos estocásticos de orden superior,  sobre contratos de opciones del Grupo Financiero Galicia (GGAL) negociados en la Bolsa de Comercio de Buenos Aires, Argentina. Primero se analiza la distribución de probabilidad de rendimientos de subyacente;  luego el modelo se somete a iteración para  obtener los valores implícitos de la volatilidad, asimetría y curtosis. Las principales conclusiones son: la forma aplanada de la curva de volatilidad implícita del modelo y  el significativo peso de la asimetría y curtosis en el precio de las opciones ?muy fuera\/dentro del dinero?.                                           Palabras claves: Volatilidad implícita, Edgeworth expansion, Asimetría, Curtosis.                                         Clasificación JEL:  G1; G13                                                                                                                                                                 Abstrac                                         In this document the Edgeworth expansion is used in the Black-Scholes model for estimating the implicit volatility and the impact of the higher stochastic moments on the option price, over Grupo Financiero Galicia (GGAL) stock options contracts trading at Buenos Aires Stocks Exchange, Argentina. First the returns´ probability distribution of the underlying is analysed; then the model is subject to iteration for obtain volatility, skewnnes and kurtosis implicit values. The main conclusions are: the flat shape of the volatility curve of the model and the significant weight of the skewnnes and kurtosis in the prices of the ?highly at-out the money?                                           Key words: Implied Volatility, Edgeworth expansion, Skewnnes, Kurtosis.                                         JEL Code: G1; G13                                   ","palabras_clave":"Volatilidad implícita|Expansión Edgeworth|Asimetría|Curtosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39474,"idioma_id":4,"titulo":"Integrated scheduling of resource-constrained flexible manufacturing systems using constraint programming","resumen":"This contribution presents a novel approach to address the scheduling of resource-constrained flexible manufacturing systems (FMSs). It deals with several critical features that are present in many FMS environments in an integrated way. The proposal consists in a constraint programming (CP) formulation that simultaneously takes into account the following sub-problems: (i) machine loading, (ii) manufacturing activities scheduling, (iii) part routing, (iv) machine buffer scheduling, (v) tool planning and allocation, and (vi) AGV scheduling, considering both the loaded and the empty movements of the device. Before introducing the model, this work points out the problems that might appear when all these issues are not concurrently taken into account. Then, the FMS scheduling model is presented and later assessed through several case-studies. The proposed CP approach has been tested by resorting to problems that consider dissimilar number of parts, operations per part, and tool copies, as well as different AGV speeds. The various examples demonstrate the importance of having an integrated formulation and show the important errors that can occur when critical issues such as AGV empty movements are neglected.","palabras_clave":"FLEXIBLE MANUFACTURING SYSTEMS|RESOURCE-CONSTRAINED SCHEDULING|CONSTRAINT-PROGRAMMING|AUTOMATED JOB-SHOP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39475,"idioma_id":4,"titulo":"Auditory localization and precedence effect: An exploratory study in infants and toddlers with visual impairment and normal vision","resumen":"The precedence effect is a spatial hearing phenomenon implicated in sound localization on reverberant environments. It occurs when a pair of sounds, with a brief delay between them, is presented from different directions; listeners give greater perceptual weight to localization cues coming from the first-arriving sound, called lead, and suppress localization cues from the later-arriving reflection, called lag. Developmental studies with sighted infants show that the first responses to precedence effect stimuli are observed at 4-5 months of life. In this exploratory study, we use the minimum audible angle (MAA) paradigm in conjunction with the observer-based psychophysical procedure to test the ability of infants and toddlers, with visual impairment and normal vision, to discriminate changes in the azimuthal position of sounds configured under precedence effect conditions. The results indicated that similar and, in some conditions, higher performances were obtained by blind toddlers when compared to sighted children of similar age, and revealed that the observer-based psychophysical procedure is a valuable method to measure auditory localization acuity in infants and toddlers with visual impairment. The video records showed auditory orienting behaviors specific of the blind children group.","palabras_clave":"PRECEDENCE EFECT|LOCALIZATION ACUITY|BLIND CHILDREN|DEVELOPMENTAL PSYCHOACOUSTICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39476,"idioma_id":4,"titulo":"Persistence of measles neutralizing antibody related to vaccine and natural infection acquired before HIV infection","resumen":"Abstract  Little is known about long-lasting measles protective immunity when exposure to wild-type or vaccine measles virus precedes HIV infection. The results obtained suggest that measles immunity wanes and the lowest measles geometric mean titres (GMT) were significantly associated with measles vaccine-induced immunity in individuals that later developed HIV infection (86% prevalence, GMT 164 mIU\/ml) compared to naturally induced immunity in HIV-infected adults (100% prevalence, GMT 340 mIU\/ml, P = 0·0082) or non-HIV infected adults (100%, GMT 724 mIU\/ml, P = 0·0001), and vaccine-induced immunity in non-HIV-infected adults (100%, GMT 347 mIU\/ml, P = 0·017). The study was conducted in an area without wild-type virus circulation since 2000. The absence of virus circulating may alter the paradigm of lifelong immunity to measles virus after vaccination. As the proportion of HIV-infected individuals possessing only vaccine-induced immunity continues to grow, checking the status of measles immunity in this group is strongly recommended.","palabras_clave":"Measles|mumps| rubella|varicella"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39477,"idioma_id":5,"titulo":"Un proyecto interinstitucional de educación ambiental sobre reforestación con especies autóctonas de la provincia de Córdoba, Argentina","resumen":"Se desarrolló un proyecto escolar con estudiantes de nivel secundario (12-16 años), vinculando Escuela, Universidad y Jardín Botánico, a fin de promover el interés por la flora autóctona. Los alumnos realizaron búsquedas bibliográficas, fichas de caracterización de especies arbóreas, clasificación de semillas, ensayos de germinación e identificaron especies típicas del Espinal. Cuestionarios previos y posteriores a la intervención educativa permitieron evaluar los conceptos y percepciones. El conocimiento conceptual previo se enriqueció, pero el procedimental no mejoró. Se observaron mejores resultados a corto plazo en la integración y\/o aplicación de los contenidos a situaciones problemáticas. Sesugieren programas educativos extendidos, encuestas cortas y actividades prácticas para evaluar los cambios.","palabras_clave":"EDUCACIÓN AMBIENTAL|FLORA AUTÓCTONA|ENCUESTAS|ACTIVIDADES PRÁCTICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39478,"idioma_id":4,"titulo":"Obtaining Clean and Well-dispersed Pt NPs with a Microwave-assisted Method","resumen":"Abstract Carbon-supported platinum nanoparticles Pt\/C(NPs) are used in many fields of science. These kinds ofmaterials have been extensively studied in electrochemistrydue to the fact that they are applied in fuel cell technology.Although there are a myriad of methods for Pt NP synthesis,the need for obtaining Pt\/C NPs with a good dispersion(covering over the entire support), a narrow size distribution,and clean surface (among other parameters) is far to be overcome.On this sense herein we describe a very easy and quickmethod of synthesis of highly dispersed Pt NPs followed by asimple electrochemical cleaning step. The catalysts were electrochemicallycharacterized by studying their behavior in0.5 M H2SO4 and also by using CO as a probe during theCO electro-oxidation reaction (COEOR). This paper showshow to obtain highly dispersed and clean Pt\/C NPs thatproduce very reproducible results. Besides, we demonstratehow the presence of impurities negatively affects the electrochemicalreproducibility of Pt NPs with a clear impact on their","palabras_clave":"platinum nanoparticles|agglomeration|surface area"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39479,"idioma_id":5,"titulo":"Prácticas y estrategias para la producción, multiplicación y difusión de semillas de maíces especiales: Transferencia  al IPEA N° 233. Agustín Tosco","resumen":"El objetivo de este trabajo fue capacitar a alumnos, docentes y no docentes de la Escuela Agrotécnica Agustín Tosco(IPEA N° 233) de La Granja, Córdoba, sobre las prácticas y estrategias para la producción, multiplicación y difusiónde semillas de maíces especiales. Se realizaron encuestas diagnóstico y se dictaron clases-taller sobre el manejo deestos maíces, así como de las principales técnicas de adaptación, mejoramiento, selección, y diferentes formas deconsumo, relevando su importancia nutricional en la alimentación diaria.Se sembraron dos variedades de maíz (Pisingalloy Cuarentín). De la cosecha, se seleccionó material para una nueva siembra y se otorgaron semillas de maízOpaco y Morado. Se pactó un compromiso social, para el rescate de prácticas estratégicas para la continuidad en laproducción de estas variedades, y un manejo sustentable de los recursos disponibles en la escuela, siempre contandocon nuestro asesoramiento.","palabras_clave":"MAICES|ESPECIALES|CALIDAD|AGROALIMENTARIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39480,"idioma_id":4,"titulo":"Agglomeration and Cleaning of Carbon Supported Palladium Nanoparticles in Electrochemical Environment","resumen":"Here we investigate the electrochemical behavior of Pd\/C synthesized by reduction with ethylene glycol in the presence of polyvinylpyrrolidone (EG-PVP). EG-PVP produces nanoparticles (NPs) with a narrow size distribution, but some of them remain covered by impurities after the  synthesis. After successive voltammetric cycles, NPs become cleaner, but some agglomeration and structural modification occur; these effects affect the electrochemical behavior of Pd\/C in different ways, so we used CO as a probe to better understand the processes taking place. CO stripping shows that the general features of the multiple oxidation peaks change with the number of cycles. Possibly, CO and OH from  different NPs react when the particles agglomerate, contributing  to CO stripping changes. Finally, different active areas are found when the charges involved in CO oxidation and PdO reduction are compared. Such differences are rationalized in terms of a balance between the increase of sites which promote the oxidation of CO and the loss of area provoked by the growing of the particles.","palabras_clave":"Palladium nanoparticles |PVP |Cleaning process |Agglomeration of nanoparticles |Active surface area  |CO probe"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39481,"idioma_id":4,"titulo":"Ethanol vs. glycerol: Understanding the lack of correlation between the oxidation currents and the production of CO2 on Pt nanoparticles","resumen":"In the last decades ethanol and glycerol arose as potential fuels for fuel cells. Based on their importance to the field and molecular similarity, here we compare the electrooxidation of ethanol and glycerol on platinum nanoparticles as an attempt to learn about their differences and similarities in terms of oxidation pathways. By using in situ FTIR we interpret the electrochemical behavior in terms of different pathwaysinvolving the production of carboxylic acids for both alcohols. For ethanol, CO2 is produced from CO in a direct pathway involving several electrons, while acetic acid is produced through a parallel pathway.Conversely, for glycerol CO2 seems to be mainly produced through a sequential pathway involving carboxylic acids, each one involving few electrons. The results suggest that glycerol demands surfaces thatspeed up the oxidation of partially oxidized species formed at intermediate potentials.","palabras_clave":"Ethanol |Glycerin |Oxidation pathways |Platinum nanomaterials |Direct alcohol fuel cells"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39482,"idioma_id":5,"titulo":"Uso de la cascarilla de arroz para la remoción de azul de metileno en columnas de lecho empacado","resumen":"ABSTRACT    This work shows the use of rice husk in the removal of cationic dye methylene blue on continuous system. A factorial design 23 with center points and random distribution was implemented to evaluate the correlation of the experimental factors in the adsorption process. The considered variables were pH, particle size, salt presence, flow rate, dye initial concentration and bed depth. The samples were analyzed in defined time intervals. The amount of removed dye was quantified by UV spectroscopy - Visible. Adams-Bohart, Thomas and BDST (Bed-depht\/service time analysis) models were used to predict the breakthrough curves using non-linear regression and establish the characteristic parameters of the process.  It was found that the transference of dye toward the adsorbent is favored by a basic pH, a small particle size, low flow rate and dye concentration and high bed depth. The design of experiments established that the initial dye concentration and the bed depth were the most significant factors. Regarding the models, the Thomas provided the best fit to describe the breakthrough curves in experimental conditions and Adams-Bohart was found suitable for dynamic behavior limited to the initial part. Finally, BDST model exhibited a good correlation and allowed to establish that bed depth is a determinant factor for scaling process.","palabras_clave":"Adsorción en columna|altura de lecho|colorante catiónico|curva de ruptura|Diseño de experimentos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39484,"idioma_id":4,"titulo":"Mapping the fluorescence performance of a photochromic ? fluorescent system coupled with gold nanoparticles at the single molecule ? single particle level","resumen":"Single-molecule (SM) fluorescence microscopy was used to investigate the photochromic fluorescent system spiropyran&#8722;merocyanine (SP &#8596; MC) interacting with gold nanoparticles (AuNPs). We observe a significant increase in the brightness of the emissive MC form, in the duration of its ON time, and in the total number of emitted photons. The spatial distribution of SMs with improved photophysical performance was obtained with 40 nm precision relative to the nearest AuNP. We demonstrate that even photochromic systems with poor photochemical performance for SM can become suitable for long time monitoring and high performance microscopy by interaction with metallic NP.","palabras_clave":"Fluorescence|Nanoparticles|Single-Molecule|Microscopy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39485,"idioma_id":4,"titulo":"Fumigant toxicity of five essential oils rich in ketones against Sitophilus zeamais (Motschulsky)","resumen":"Essential oils (EOs) and individual compounds act as fumigants against  insects found in stored products. In fumigant assays, Sitophilus zeamais  Motschulsky adults were treated with essential oils derived from Aphyllocladus  decussatus Hieron, Aloysia polystachya Griseb, Minthostachys verticillata  Griseb Epling and Tagetes minuta L , which are rich in ketones and their major  components: alfa-thujone, R-carvone, S-carvone, (-) menthone, R (+) pulegone  and E-Z- ocimenone. M. verticillata oil was the most toxic ( LC50: 116,6 &#956;l \/L  air) characterized by a high percentage of menthone (40.1%) and pulegone  (43.7%). All ketones showed insecticidal activity against S. zeamais. However,  pulegone (LC50: 11,8 &#956;l\/L air), R- carvone (LC50: 17,5 &#956;l\/L air), S-carvone (LC50:  28,1 &#956;l\/L air) and E-Z-ocimenone (LC50: 42,3 &#956;l\/L air) were the most toxic. These  ketones are a,b-unsaturated carbonyl. This feature could play a fundamental  role in the increase of insecticidal activity against S. zeamais.","palabras_clave":"SITOPHILUS ZEAMAIS|ESSENTIAL OILS|KETONES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39486,"idioma_id":5,"titulo":"Dynamic Programming for the control of power quality in inbalanced medium voltage networks with distributed generation","resumen":"This paper presents results achieved by an implementation of Dynamic   Programming as power quality control logic on electrical distribution in   unbalanced medium-voltage systems. This control system intends   distributors to optimize quality indicators and generation costs   operation. The aim is to improve energetic efficiency by reducing   additional network losses produced by imbalance. Besides it intends to   profit the capacity of transmission and distribution network and control   the spread of the imbalance index. For this purpose, we worked on a   real distribution system of EPEC enterprise of the Province of Co&#769;rdoba,   Argentina, by modeling its actual behavior by the ATP \/ EMTP software.   It then builds using MATLAB, a platform for control and an algorithm is   developed to process information to control and adjust the system under   the new operating conditions. We conclude that the final results show   the ability to control, regulate and reduce the imbalance optimizing the   Distributed Generation income. Finally we present up to date   achievements.","palabras_clave":"Dynamic Programming|Networking Medium Voltage|Power Quality|Distributed Generation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39487,"idioma_id":4,"titulo":"Protein Universe Containing a PUA  RNA binding domain","resumen":"Here, we review current knowledge about pseudouridine synthase and archaeosine transglycosylase (PUA)-domain-containing proteins to illustrate progress in this field. A methodological analysis of the literature about the topic was carried out, together with a ?qualitative comparative analysis? to give a more comprehensive review. Bioinformatics methods for whole-protein or protein-domain identification are commonly based on pairwise protein sequence comparisons; we added comparison of structures to detect the whole universe of proteins containing the PUA domain. We present an update of proteins having this domain, focusing on the specific proteins present in Homo sapiens (dyskerin, MCT1, Nip7, eIF2D and Nsun6), and explore the existence of these in other species. We also analyze the phylogenetic distribution of the PUA domain in different species and proteins. Finally, we performed a structural comparison of the PUA domain through data mining of structural databases, determining a conserved structural motif, despite the differences in the sequence, even among eukaryotes, archaea and bacteria. All data discussed in this review, both bibliographic and analytical, corroborate the functional importance of the PUA domain in RNA-binding proteins.&nbsp;","palabras_clave":"Dyskerin|Telomerase"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39488,"idioma_id":4,"titulo":"Mitochondrial Fusion and ERK activity Regulate Steroidogenic Acute Regulatory Protein Localization in Mitochondria","resumen":"The rate-limiting step in the biosynthesis of steroid hormones, known as the transfer of cholesterol from the outer to the inner mitochondrial membrane, is facilitated by StAR, the Steroidogenic Acute Regulatory protein. We have described that mitochondrial ERK1\/2 phosphorylates StAR and that mitochondrial fusion, through the up-regulation of a fusion protein Mitofusin 2, is essential during steroidogenesis. Here, we demonstrate that mitochondrial StAR together with mitochondrial active ERK and PKA are necessary for maximal steroid production. Phosphorylation of StAR by ERK is required for the maintenance of this protein in mitochondria, observed by means of over-expression of a StAR variant lacking the ERK phosphorylation residue. Mitochondrial fusion regulates StAR levels in mitochondria after hormone stimulation. In thisstudy, Mitofusin 2 knockdown and mitochondrial fusion inhibition in MA-10 Leydig cells diminished StAR mRNA levels and concomitantly mitochondrial StAR protein. Together our results unveil the requirement of mitochondrial fusion in the regulation of the localization and mRNA abundance of StAR. We here establish the relevance of mitochondrialphosphorylation events in the correct localization of this key protein to exert its action in specialized cells. These discoveries highlight the importance of mitochondrial fusion and ERK phosphorylation in cholesterol transport by means of directing StAR to the outer mitochondrial membrane to achieve a large number of steroid molecules per unit of StAR.","palabras_clave":"MITOCHONDRIAL FUSION|ERK ACTIVITY|STEROIDOGENESIS|StAR LOCALIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39489,"idioma_id":5,"titulo":"Reseña de Claves para repensar el agro argentino de Anllo, Bisang y Campi","resumen":"La reseña recorre los capítulos del Libro que analiza los diferentes aspectos que comprenden las transformaciones del agro argentino.","palabras_clave":"AGRICULTURA ARGENTINA|INNOVACION|CAMBIO|TECNOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39490,"idioma_id":4,"titulo":"Distribution of (-)-hamansic acid A in South American species of Flourensia and phytotoxic effects of leaf aqueous extracts","resumen":"The presence of the phytotoxic sesquiterpene (-)-hamanasic acid A {(-)HAA; 7-carboxy-8-hydroxy-1(2), 12(13)-dien-bisabolene} isolated from Flourensia  campestris (FC), was investigated in the South American species of the genus, together with the evaluation of the phytotoxic activity of their leaf aqueous  extracts. (-)HAA was identified and isolated from F. fiebrigii (FF) and F. oolepis (FO), being chemically (GC-MS, NMR, [&#945;]D) and biologically (bioassayed  on lettuce) indistinguishable from that of FC, while no (-)HAA was found in F. hirta (FH), F. riparia (FR) and F. niederleinii (FN). Its leaf content in FF was  similar to that found in FC (ca. 15 mg g-1 WT) and significantly higher than in FO (0.8 mg g-1 WT). The screening for the presence of (-)HAA in other species  of Flourensia communities showed that its natural occurrence is restricted only to Flourensia species. No (-)HAA could be detected in any of the 37 -most  representative- species of these communities (26 natives, 11 exotics), despite many of them belong to the same family and tribe as Flourensia spp. Leaf  aqueous extracts of all Flourensia species exhibited strong inhibitory effects on lettuce germination and on root and shoot growth, regardless of the presence  and content of (-)HAA. These results strongly suggest the existence of other powerful phytotoxic compounds in those Flourensia spp lacking (-)HAA. Our  results clearly show that (-)HAA only pertains to some species of the genus Flourensia. Relative to previous exomorphologic groupings of the genus, our  chemotaxonomic data would give support to the close link described between FC and FF, but not with FR. In addition, the fact that (-)HAA was also found in  FO, which belongs to a second different line, also points out that species position in this lineage would deserve to be revisited. The restricted production of  (-)HAA by Flourensia in their communities suggests its special link with the genus, and sustains its putative allelochemical role.","palabras_clave":"Flourensia|(-)hamanasic acid A|Phytotoxic activity|Sesquiterpenes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39491,"idioma_id":4,"titulo":"Renal overexpression of atrial natriuretic peptide and hypoxia inducible factor-1&#945; as adaptive response to a high salt diet","resumen":"In the kidney, a high salt intake favors oxidative stress and hypoxia and causes the development of fibrosis. Both atrial natriuretic  peptide (ANP) and hypoxia inducible factor (HIF-1&#120572;) exert cytoprotective effects. We tested the hypothesis that renal expression  of ANP and HIF-1&#120572; is involved in a mechanism responding to the oxidative stress produced in the kidneys of rats chronically fed a  high sodiumdiet. Sprague-Dawley rats were fed with a normal salt (0.4% NaCl) (NS) or a high salt (8% NaCl) (HS) diet for 3 weeks,  with or without the administration of tempol (T), an inhibitor of oxidative stress, in the drinking water. We measured the mean  arterial pressure (MAP), glomerular filtration rate (GFR), and urinary sodium excretion (UVNa). We evaluated the expression of  ANP, HIF-1&#120572;, and transforming growth factor (TGF-&#120573;1) in renal tissues by western blot and immunohistochemistry. The animals  fed a high salt diet showed increased MAP and UVNa levels and enhanced renal immunostaining of ANP, HIF-1&#120572;, and TGF-&#120573;1.  The administration of tempol together with the sodium overload increased the natriuresis further and prevented the elevation of  blood pressure and the increased expression of ANP, TGF-&#120573;1, and HIF-1&#120572; compared to their control.These findings suggest that  HIF-1&#120572; and ANP, synthesized by the kidney, are involved in an adaptive mechanism in response to a sodium overload to prevent  or attenuate the deleterious effects of the oxidative stress and the hypoxia on the development of fibrosis.","palabras_clave":"Oxidative stress|ANP|Salt"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39492,"idioma_id":4,"titulo":"Immunization with antigenic extracts of Leishmania associated with Montanide ISA 763 adjuvant induces partial protection in BALB\/c mice against Leishmania (Leishmania) amazonensis infection","resumen":"J Microbiol Immunol Infect. 2014 Mar 21. pii: S1684-1182(14)00009-7. doi: 10.1016\/j.jmii.2014.01.006. [Epub ahead of print]  Immunization with antigenic extracts of Leishmania associated with Montanide ISA 763 adjuvant induces partial protection in BALB\/c mice against Leishmania (Leishmania) amazonensis infection.  Cargnelutti DE1, Salomón MC2, Celedon V3, García Bustos MF4, Morea G2, Cuello-Carrión FD3, Scodeller EA3.  Author information  Abstract  BACKGROUND\/PURPOSE:  A proper adjuvant has a relevant role in vaccine formulations to generate an effective immune response. In this study, total Leishmania antigen (TLA) formulated with Montanide ISA 763 or R848 as adjuvants were evaluated as a first generation Leishmania vaccine in a murine model.  METHODS:  Immunization protocols were tested in BALB\/c mice with a subcutaneous prime\/boost regimen with an interval of 3 weeks. Mice immunized with unadjuvanted TLA and phosphate-buffered saline (PBS) served as control groups. On Day 21 and Day 36 of the protocol, we evaluated the humoral immune response induced by each formulation. Fifteen days after the boost, the immunized mice were challenged with 1 × 105 promastigotes of Leishmania (Leishmania) amazonensis in the right footpad (RFP). The progress of the infection was followed for 10 weeks; at the end of this period, histopathological studies were performed in the RFP.  RESULTS:  Vaccines formulated with Montanide ISA 763 generated an increase in the production of immunoglobulin G (IgG; p < 0.05) compared with the control group. There were no statistically significant differences in IgG1 production between the study groups. However, immunization with TLA-Montanide ISA 763 resulted in an increase in IgG2a compared to the unadjuvanted control (p < 0.001). Also noteworthy was the fact that a significant reduction in swelling and histopathological damage of the RFP was recorded with the Montanide ISA 763 formulation.  CONCLUSION:  We conclude that the immunization of BALB\/c mice with a vaccine formulated with TLA and Montanide ISA 763 generated a protective immune response against L. (L.) amazonensis, characterized by an intense production of IgG2a.","palabras_clave":"LEISHMANIA|VACUNAS|ADYUVANTES|RESPUESTA INMUNE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39493,"idioma_id":4,"titulo":"Impact of tumor necrosis factor receptor p55 deficiency in susceptibility of C57BL\/6 mice to infection with Leishmania (Leishmania) amazonensis","resumen":"Tumor necrosis factor (TNF) is involved in host resistance to several intracellular pathogens.  Although the critical role of TNF receptor (TNFR)p55 in Leishmania (Leishmania) major infection  has been demonstrated, the impact of TNFRp55 deficiency on L. (L.) amazonensis infection  has not been explored. L. (L.) amazonensis-infected TNFRp55\/ mice failed to resolve  lesions, whereas C57BL\/6 wild-type mice completely healed. The susceptibility of the  TNFRp55\/ mice was characterized by higher lesion size and histopathological damage in  comparison with the wild-type mice. A marked increased of the splenic index was observed","palabras_clave":"C57BL\/6 mice|Infection susceptibility;|Leishmania (Leishmania) amazonensis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39494,"idioma_id":4,"titulo":"Dynamics of visibility, confidence, and choice during eye movements","resumen":"We Study the dynamics of objective and subjective measures of visibility and choice in brief presentations occurring within a fixation during free eye-movements. We show that brief presentations yield  homogeneous levels of performance in a window that extends almost throughout the entire fixation. Instead, confidence judgments vary for presentations occurring at different moments of the fixations. When the target occurs close to the onset of the fixation, it is reported accurately but with lower values of confidence; when it occurs close to the end of the fixation, it is reported with high confidence (Experiments 1 and 2). Consistently, in experiments in which participants can freely choose to report items, we observe a report bias toward the end of the fixation, where the maximum of confidence occurs for experiments with a single target (Experiments 3 and 4). Hence, these results suggest that confidence is not merely a measure of accumulated stimulus energy but instead varies reflecting an endogenous integration process by which later stimuli are as signed greater confidence.","palabras_clave":"CHOICE|CONFIDENCE|DECISION MAKING|EYE MOVEMENTS|VISIBILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39495,"idioma_id":4,"titulo":"Streakline-based closed-loop control of a bluff body flow","resumen":"A novel closed-loop control methodology is introduced to stabilize a cylinder wake flow based on images of streaklines. Passive scalar tracers are injected upstream the cylinder and their concentration is monitored downstream at certain image sectors of the wake. An AutoRegressive with eXogenous inputs mathematical model is built from these images and a Generalized Predictive Controller algorithm is used to compute the actuation required to stabilize the wake by adding momentum tangentially to the cylinder wall through plasma actuators. The methodology is new and has real-world applications. It is demonstrated on a numerical simulation and the provided results show that good performances are achieved.","palabras_clave":"Flow Control|Closed loop"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39496,"idioma_id":4,"titulo":"On the relation between Seyfert 2 accretion rate and environment at z < 0.1","resumen":"We analyse different properties of the small-scale environment of Seyfert 2 for two samples selected according to the accretion                       rate parameter , R,   from the Sloan Digital Sky Survey, Data Release 7 survey. We compare   the results with two control samples of non-active                       galaxies that cover the same redshift range,   luminosity, colours, morphology, age and stellar mass content. Our study   shows                       that both high and low accretion rate subsamples   reside in bluer and lower density environments than the control samples.                       However, we find that this difference is at least   two times stronger for the low accretion rate Seyferts. In the vicinity                       of Seyfert 2, red galaxies have systematically   lower values of stellar mass as compared with corresponding control   samples.                       The lower values of stellar mass for red neighbours   is more significant at higher density environments and it is more   evident                       for low accretion rate Seyfert. We also find that   this effect is independent of the host´s stellar mass. Our results are   consistent                       with a scenario where active galactic nucleus   occurrence is higher in lower\/medium density environments with a higher   merger                       rate and a lack of a dense intergalactic medium   (that can strip gas from these systems) that provide suitable conditions   for                       the central black hole feeding. We find this   particularly evident for the low accretion rate Seyferts that could   compensate                       through the intergalactic medium the lack of gas of   their hosts.","palabras_clave":"galaxies|seyfert|statistics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39498,"idioma_id":4,"titulo":"Steam-methane reforming at low temperature on nickel-based catalysts","resumen":"    In this work, we report the activity results obtained in steam-methane  reforming (SMR) at 500 and 600 C using four nickel-based catalysts: (a) Ni\/Al2O3  and Ni\/SiO2 , prepared by incipient wetness impregnation method and (b)  Ni?Zn?Al and Ni?Mg?Al, prepared by coprecipitation method. In all of the  samples, the nickel load ranged between 7% and 9%. The catalytic activity in  SMR at steady state followed the pattern: Ni?Mg?Al &nbsp;Ni?Zn?Al &gt; Ni\/Al2O3 &gt; Ni\/SiO2 .  According to characterization results, the interaction between Ni2+ species and support in precursor oxides  was stronger in Ni?Mg?Al and Ni?Zn?Al than in Ni\/Al2O3 and Ni\/SiO2. . After  activation in H2flow, large metal nickel particles with low or none interaction with  the support were obtained in the case of Ni\/a-Al2O3 and Ni\/SiO2. &nbsp;On the contrary, small metal particles,  between 3 and 6 nm, in high interaction with support were obtained in Ni?Zn?Al  and Ni?Mg?Al catalysts. The metal phase formed in Ni?Mg?Al and Ni?Zn?Al was the  most active and resistant to sintering under reaction conditions at T 6 600 C.  It was also found that carbon nanofibers were formed on Ni\/a-Al2O3, Ni\/SiO2 and  Ni?Mg?Al catalysts during SMR at 600 C. The amount and diameter of nanofibers  formed on Ni?Mg?Al were lower than on catalysts prepared by impregnation  method, which is in agreement with the relative sizes of metal nickel particles  in each case.  ","palabras_clave":"STEAM-METHANE REFORMING|NICKEL CATALYSTS|METAL?SUPPORT INTERACTION|SYNTHESIS GAS|HYDROGEN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39499,"idioma_id":4,"titulo":"Urban propolis from San Juan province (Argentina). Ethnopharmacological uses and antifungal activity against Candida and dermatophytes","resumen":"Propolis is widely used in the folk medicine of San Juan province (Argentina) to treat several diseases,including cold, cough, muscle aches and superficial mycoses. We report the in vitro antifungal activity ofurban propolis, evaluated with CLSI protocols in addition to the evaluation of their chemical profile byHPLC-ESI-MS\/MS techniques.The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum werethe most susceptible species and guided the fractionation of urban propolis, which was performed withSephadex LH-20 leading to eight fractions (I-VIII). These fractions showed high antifungal activitiesagainst dermatophytes (MICs = 16.0-62.5 g\/mL) and yeasts (MICs = 31.2-125 g\/mL) being III, V and VIthe most active ones (MIC100= 16-31.2 g\/mL). They also, showed fungicidal capacity (a condition highlyappreciated in antifungal drugs to avoid recurrence) with MFC values between 31.2 and 62.5 g\/mL.From the most active fractions, two lignans: 3-methyl-nordihydroguaiaretic acid (MNDGA) (1), andnordihydroguaiaretic acid (NDGA) (2), in addition to three flavonoids: chrysin (3), pinocembrin (4) andgalangin (5), were isolated and quantified by HPLC?PDA-MS\/MS as the main antifungal compounds.Lignans 1 and 2 showed strong activities against T. mentagrophytes, T. rubrum and Microsporum gypseum(MICs between 31.2 and 62.5 g\/mL), and 1 showed strong activity against Candida albicans, Candida trop-icalis and Cryptococcus neoformans (MICs between 31.2 and 62.5 g\/mL). Regarding flavonoids, all yeastswere sensitive to 5 (MIC = 31.2 g\/mL), whereas the dermatophytes T. mentagrophytes and T. rubrum andall yeasts were moderately inhibited by 4 (MIC = 31.2?250 g\/mL). Finally, chrysin (3) showed low activ-ity against yeasts and dermatophytes (MIC = 250 g\/mL). These results support that Argentinean urban propolis, which are frequently used by beekeepers for the preparation of syrups, tinctures and creams, arevaluable natural product for the improving of human health, particularly fungal infections. It is also wor-thy to take into account that its chemical composition contains mainly two antifungal lignans, associatedwith the medicinal Larrea genus.","palabras_clave":"ARGENTINEAN POPOLIS|DERMATOPHYTES|LIGNANS|HPLCESI-MS\/MS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39500,"idioma_id":4,"titulo":"Sensitivity Analysis and Parameter Estimation of Heat Transfer  and Material Flow Models in Friction Stir Welding","resumen":"Although numerical models of heat transfer and material flow have contributed to understand the underlying mechanisms of friction stir welding (FSW), there are certain input model parameters that can not be easily determined. Thus, the model predictions do not always agree with experimental results. In this work, sensitivity analysis and parameter estimation were applied to test heat transfer and material flow models. A forward-difference approximation was used to compute the sensitivity of the solution with respect to the unknown model parameters. The Levenberg-Marquardt (LM) method was applied to solve the nonlinear parameter estimation problem. The numerical models were developed by the finite element method (FEM). The way in which the unknown model parameters independently affect the results and the importance of the location of reference points that take part in the objective function were determined.","palabras_clave":"friction stir welding|sensitivity analysis, parameter estimation|finite element method|CFD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39501,"idioma_id":4,"titulo":"Effect of the surfactant benzalkonium chloride in the sorption of paraquat and cadmium on montmorillonite","resumen":"Abstract  Pesticides, heavy metals and surfactants can share the same region or site in the environment and thus they may compete for the surface of minerals. A competitive study of the adsorption between the cationic surfactant benzalkonium chloride (BAC) with the heavy metal cadmium (Cd(II)) and the cationic herbicide paraquat (PQ) on montmorillonite is presented. Adsorption isotherms for BAC, PQ and Cd(II) were performed in single solute systems and also in binary solute systems, PQ+BAC and Cd(II)+BAC in order to evaluate the effects of BAC on the adsorption of the other two substances. The affinities of BAC and PQ were strong and similar, thus BAC affected significantly the adsorption of PQ and vice versa. The affinity of Cd(II) for the montmorillonite surface was low, thus BAC affected appreciably Cd(II) adsorption, but the heavy metal did not modify BAC adsorption. XRD data show that BAC molecules control the magnitude of the basal spacing.","palabras_clave":"BENZALKONIUM CHLORIDE|PARAQUAT|CADMIUM|COMPETITIVE ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39502,"idioma_id":4,"titulo":"Molecular Chaperone Activity and Biological Regulatory Actions of the TPR-Domain Immunophilins FKBP51 and FKBP52","resumen":"Immunophilins comprise a family of intracellular  proteins with peptidyl-prolyl-(cis\/trans)-isomerase activity. These foldases are abundant,  ubiquitous, and able to bind immunosuppressant drugs, from which the term  immunophilin derives. Family  members are found in abundance in virtually all organisms and subcellular  compartments, and their amino acid sequences are conserved phylogenetically.  Immunophilins possess the ability to function as molecular chaperones favoring  the proper folding and biological regulation of their biological actions.  Their ability to interact via their TPR domains with the 90-kDa heat-shock  protein, and through this chaperone, with several signalling cascade factors is  of particular importance. Among the family members, the highly homologous  proteins FKBP51 and FKBP52 were first characterized due to their ability to  interact with steroid hormone receptors. Since then, much progress has  been made in understanding the mechanisms by which they regulate receptor  signaling and the resulting roles they play not only in endocrine processes,  but also in cell architecture, neurodifferentiation, and tumor progression. In  this article we review the most relevant features of these two immunophilins  and their potential as pharmacologic targets.","palabras_clave":"HSP90|FKBP51|FKBP52|IMMUNOPHILIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39503,"idioma_id":4,"titulo":"Fluorescence polarization assay for the diagnosis of anti-Brucella abortus antibodies in cattle serum: adaptation for its use in microplates and Comparison with conventional agglutination tests","resumen":"Bovine brucellosis, which is endemic in Argentina, is controlled by vaccination and culling  of infected cattle. Conventional agglutination test and primary binding assays like ELISA  and FPA (Fluorescence Polarization Assay) are used for the identification of infected cattle.  The aim of the present study was to set the conditions for a FPA in 96-well microplates,  and to compare its diagnostic performance with the conventional agglutination tests  currently used in Argentina. High percentage of false positive reactions were found in the  agglutination tests compared to FPA, while 8% of FPA-negative samples gave suspected  result in the agglutination tests. Due to its high testing capacity, economy of antigen, lack  of false positive reactions, and avoidance of re-testing of cattle with suspected result in  agglutination tests, the FPA conducted in microplates is a suitable test to be implemented  in the control and eradication of brucellosis in Argentina","palabras_clave":"BRUCELLOSIS|FLUORESCENCE POLARIZATION|AGGLUTINATION|MICROPLATE|SEROLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39504,"idioma_id":5,"titulo":"El lugar como categoría de análisis del espacio público. Complejidad, (in)materialidad, resignificación y planificación del espacio público","resumen":"La complejidad es una propiedad inherente a los espacios urbanos. Dentro de ellos, los espacios públicos muestran en la actualidad una complejidad creciente y variable, acorde a las diversas formas de percibir, concebir, producir y consumir estos espacios. Los espacios públicos se conforman de multiplicidad de lugares. Los lugares son síntesis de formascontenidos y revelan la compleja trama de relaciones que subyacen al espacio urbano. El concepto de lugar ofrece alternativas para la observación, análisis y actuación sobre el ambiente urbano y especialmente del espacio público, en tanto en él se materializan intercambios sociales, culturales, políticos y económicos. En un intento por descubrir la relación dialéctica naturaleza-sociedad en el espacio público, recurrimos al concepto de lugar como categoría analítica para interpretar la materialidad e inmaterialidad en los procesos de producción y consumo del espacio público urbano y, para captar la importancia de su complejidad en miras a la formulación de políticas públicas y al rol que luego estas juegan en dichos procesos.","palabras_clave":"Lugar|Complejidad|Espacio Público|Políticas Públicas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39505,"idioma_id":4,"titulo":"TWO NOVEL AND SIMPLE CORRELATIONS TO ESTIMATE EQUILIBRIUM WATER DEW POINT FOR NATURAL GAS DEHYDRATION PROCESS","resumen":"Water is probably the most undesirable component found in crude natural gas because its presence can produce hydrate formation, and it can also lead to corrosion or erosion problems in pipes and equipment. Natural gas must be dehydrated before being transported through a long distance to ensure an efficient and trouble-free operation. Thermodynamic modelling of triethyleneglycol (TEG)-water system is still rather inaccurate, especially with regard to systems at high temperature and high TEG concentration. As a consequence, design and operation of absorber towers are affected by the lack of accurate data. Two novel correlations have been developed to estimate the equilibrium water dew point of a natural gas stream by evaluating experimental data and literature. These data were collected and analyzed by means of images scanned with MATLAB software R2012B version. An average percentage error is of 1-2% for linear correlation and it is of 2-3% for non-linear correlation. Results are quite accurate and they are consistent with literature data. Due to the simplicity and precision of the correlations developed in this work, the equations obtained have a great practical value. Consequently, they allow process engineers to perform a quick check of the water dew point at different conditions without using complex expressions or graphics.","palabras_clave":"CORRELATION|DEW POINT|NATURAL GAS|TEG - WATER SYSTEM|TRIETHYLENE GLYCOL|WATER DEHYDRATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39506,"idioma_id":4,"titulo":"Genetic characterization of Callosciurus Asiatic squirrels introduced in Argentina","resumen":"Squirrels have been traded in the pet market for several decades, and numerous species have established in the wild. TheAsiatic species Callosciurus erythraeus and Callosciurus finlaysonii have been introduced into other parts of Asia, in Europe andSouth America. In this study, (1) we conducted a genetic characterization of C. erythraeus introduced into Argentina andcompared them with native and introduced populations in Asia, and (2) we analyzed genetic variation among the four invasionfoci in Argentina in order to corroborate that the pathway of invasion was a single introduction event in the country andsubsequent translocations. We analyzed mitochondrial (cytochrome b, Cyt b; cytochrome oxidase c subunit I, COI andD-loop) and nuclear (recombination activating gene I, RAGI) DNA markers using the classical method (DNA barcoding gapanalysis) and also the Automatic Barcode Gap Discovery method (ABGD). The markers D-loop, COI, and RAG1 indicatedthat the introduced squirrels from the different invasion foci formed a monophyletic group that, together with only onehaplotype for the D-loop and COI markers, supported the hypothesis of one introduction event into Argentina followed bysubsequent translocations. Unexpectedly, sequences from squirrels captured in Argentina were more related to C. finlaysoniithan to C. erythraeus for D-loop and Cyt b markers. However, intraspecific variation among sequences of C. erythraeusbelonging to different subspecies or collected in different regions was large and comparable with the distance to the sequencesfrom Argentina. The ABGD method also indicated large genetic variability within C. erythraeus and close proximity betweensquirrels from Argentina and C. finlaysonii. The complex taxonomy of Callosciurus, as occurs with the sister species C. erythraeusand C. finlaysonii, requires a thorough systematic revision. A simultaneous analysis of diagnostic morphological characters andgenetic markers is needed and will provide new insight regarding the worldwide invasion of Asiatic squirrels.","palabras_clave":"INVASIVE SQUIRRELS|ARGENTINA|ASIATIC SQUIRRELS|MITOCHONDRIAL DNA|NUCLEAR DNA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39507,"idioma_id":5,"titulo":"Financiamiento público del gasto total en salud: un estudio ecológico por países según niveles de ingreso","resumen":"En las últimas décadas el gasto total en salud (gts) ha aumentado tanto en las economías desarrolladas como en las emergentes. El presente trabajo es un estudio ecológico descriptivo y mixto. Tomando una muestra de 192 países agrupados por niveles de ingresos, se analizó: i) los patrones de financiamiento público del gts, ii) la proporción que representó el gasto público en  salud en los gastos generales de gobierno, y iii) la hipótesis de Globerman y Vining referida a la existencia de una correlación negativa entre el financiamiento público y el gts como porcentaje del pbi. Los resultados muestran que los gobiernos que más se involucran en el sector salud poseen en promedio un gts per cápita más alto. Asimismo, la relación entre financiamiento  público del gts y gts como porcentaje del pbi es negativa y estadísticamente significativa solo en los países ricos de la ocde y en los pobres.","palabras_clave":"gasto en salud|financiamiento de la atención de la salud|sector salud|sector público"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39508,"idioma_id":4,"titulo":"Co-exposure of the organic nanomaterial fullerene C60  with benzo[a]pyrene in Danio  rerio  (zebrafish) hepatocytes: Evidence of toxicological interactions","resumen":"Compounds  from  the  nanotechnology  industry,  such  as  carbon-based  nanomaterials,  are  strong  candidates  to  contaminate  aquatic  environments  because  their  production  and  disposal  have  exponentially grown  in  a  few  years. Previous  evidence  shows  that  fullerene  C60,  a  carbon  nanomaterial,  can  facilitate the  intake  of  metals  or  PAHs  both  in  vivo  and  in  vitro,  potentially  amplifying  the  deleterious  effects  of these  toxicants  in  organisms.  The  present  work  aimed  to  investigate  the  effects  of  fullerene  C60 in  a Danio  rerio  (zebrafish)  hepatocyte  cell  lineage  exposed  to  benzo[a]pyrene  (BaP)  in  terms  of  cell  viability, oxidative  stress  parameters  and  BaP  intracellular  accumulation.  Additionally,  a  computational  docking was  performed  to  investigate  the  interaction  of  the  fullerene  C60 molecule  with  the  detoxificatory  and antioxidant  enzyme  GST.  Fullerene  C60 provoked  a  significant  (p    0.05)  alter  the  enzyme  activity  when  added  to  GST purified  extracts  from  the  zebrafish  hepatocyte  cells.  These  results  show  that  fullerene  C60can  increasethe  intake  of  BaP  into  the  cells,  decreasing  cell  viability  and  impairing  the  detoxificatory  response  by phase  II  enzymes,  such  as  GST,  and  this  latter  effect  should  be  occurring  at  the  transcriptional  level.","palabras_clave":"NANOTOXICOLOGIA|FULERENO|CULTIVO CELULAR|GLUTATIONA-S-TRANSFERASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39509,"idioma_id":4,"titulo":"Effect of reduction of lactose in yogurts by addition of b-galactosidase enzyme on volatile compound profile and quality parameters","resumen":"A comparative study between reduced-lactose yogurts made with added b-galactosidase (E yogurts) and controls (C yogurts) was performed. The evolution of lactose content, pH, acidity and volatile compounds was measured during fermentation and storage at 5 °C. The hydrolysis percentages of lactose ranged from 75% to 78% in E yogurts and from 10% to 13% in C yogurts at the end of manufacture and stayed without changes throughout storage. There were no significant differences in pH and titratable acidity values among yogurts. A total of 22 volatile compounds were identified. The change in lactose level by the action of b-galactosidase influenced the production of some volatile compounds derived from this sugar.At the end of fermentation, minor differences in volatile composition were recorded among yogurt samples.During storage, acetaldehyde and diketone levels were always higher in hydrolysed yogurts than their respective controls.","palabras_clave":"FLAVOURS|LACTOSE|SOLID PHASE MICROEXTRACTION|YOGURT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39510,"idioma_id":4,"titulo":"Evidence of active regions for ion transport in lithium silicate glasses using the isoconfigurational ensemble. Part II","resumen":"In the context of the ionic transport in glasses, the concept of conduction channels (or pathways) has proved to be useful to rationalize both experimental and computational results. While the concept of a transport ?channel? is well defined for crystalline solid conductors, for the case of glasses this concept mainly refers to a finite region of the sample (at least in the diffusive time scale) in which mobile ions have a convenient environment to perform the electrical transport.    In the previous work, we present an alternative way to put into evidence the existence of such regions in the diffusion time scale during a molecular dynamics experiment. In fact in that work [1] we use the so-called isoconfigurational ensemble method (ICEM) and the associated concept of particle propensity, both recently introduced by Harrowell and co-workers [2]. Then the notion of particle propensity to movement?immerse in the ICEM?was employed to find the existence of regions which are dynamically more active for the moving particles: the conduction channels.    In the present paper we provide more computational evidence to support our alternative way to make evident the existence of channels that we presented in [1]: we show in this paper that our procedure is exactly equivalent to the approach previously adopted by other authors in the literature. This coincidence between the two searching strategies allow us to add more information about the nature of the channels. In fact, we can state now for the first time that the existence of the channels is defined at the very beginning of the dynamics and they remain almost unchanged even in the diffusive (nanosecond) scale. Besides, it was shown that a channel is a region of a sample which is also highly correlated dynamically during the trajectory of the moving ions.","palabras_clave":"Molecular dynamics|Ionic conductivity|Silicate glasses|Transport channels"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39511,"idioma_id":4,"titulo":"Electrodeposited Cu2ZnSnS4 thin films","resumen":"Cu2ZnSnS4 (CZTS) thin films have been prepared using Electrochemical Atomic Layer Deposition (EC-ALD) and also by one-step conventional constant potential electrodeposition. Optimal deposition conditions were investigated using cyclic voltammetry (CV). Then, based on CVs results, CZTS films were grown employing EC-ALD deposition cycles using the sequence Au\/S\/Cu\/S\/Zn\/S\/Sn\/S to form the desired quaternary compound. In parallel, conventional one-step electrodeposition was carried out at -0.85 V vs. Ag\/AgCl over 1 hour. A thermal treatment in sulfur vapor was also investigated in an attempt to optimize the stoichiometry.   The crystal structure of the films was characterized by XRD and micro Raman spectroscopy, while the morphology, thickness, topography and elemental composition were investigated using FIB-SEM and EDS.","palabras_clave":"Electrodeposition|Semiconductors|Thin films|CZTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39512,"idioma_id":4,"titulo":"Dimerization of &#945;-pinene, using Phosphotungstic acid supported on SiO2 as catalyst","resumen":"The &#945;-pinene dimerization in liquid phase was studied by using phosphotungstic acid catalysts H3PW12O40, (HPW) supported on commercial silica. These catalysts were characterized by XRD, FT-IR and FT-IR of pyridine adsorbed. Catalyst characterization by XRD showed the presence of HPW crystals on HPWSi catalyst. FT-IR spectra showed only bands assigned to the pyridine adsorption on Brønsted acid sites. The catalytic activity was found to depend on the reaction temperature and the amount of catalyst loaded in the reactor, and the highest selectivity in dimers corresponded to the HPW supported. Under reaction conditions 130ºC and 4% catalyst, the most active catalyst showed 100% &#61537;-pinene conversion and 55% selectivity to dimers. The selectivity to dimers increases with the increase of the reaction temperature and the amount of catalyst loaded in the reactor","palabras_clave":"ALPHA-PINENE|BIOJET|DIMERIZATION|TERPENES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39513,"idioma_id":4,"titulo":"A certified extension of the Krivine machine for a call-by-name higher-order imperative language","resumen":"In this paper we present a compiler that translates programs from an imperative higher-order  language into a sequence of instructions for an abstract machine. We consider an extension of  the Krivine machine for the call-by-name lambda calculus, which includes strict operators and  imperative features. We show that the compiler is correct with respect to the big-step semantics  of our language, both for convergent and divergent programs.","palabras_clave":"compiler certification|algol like language|call by name|Krivine machine"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39514,"idioma_id":4,"titulo":"Taxa delimitation in the Andropogon lateralis complex (Poaceae) in southern South America based on morphometrical analysis","resumen":"In the tribe Andropogoneae, morphological variation is remarkable, mainly in theinflorescence, on the pair of spikelets, which are the core elements of the inflorescence. The genusAndropogon includes the Andropogon lateralis complex, which is distributed primarily in South and Central America, comprising approximately twelve taxa and inter-specific hybrids. The aim of this study was to assess morphological variation in the A. lateralis complex through morphometricanalyses of specimens from natural populations. For this purpose, univariate ANOVA, as well asprincipal component analysis and discriminant analysis of 19 morphological variables ofsynflorescences, were performed revealing differences between species and interspecific hybrids. The selected diagnostic traits of species and hybrids based on quantitative characters of the synflorescences provided a valuable tool for taxonomic studies in the genus. The results obtained made it possible to generate the first identification key that includes both species and hybrids of the A. lateralis complex for South America.","palabras_clave":"ANDROPOGONEAE|ANOVA|CANONICAL DISCRIMINANT ANALYSIS|INTERSPECIFIC HYBRIDS|MORPHOLOGY|PRINCIPAL COMPONENT ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39515,"idioma_id":4,"titulo":"Effects of Chlorpyrifos and Endosulfan on Different Life Stages of the Freshwater Burrowing Crab Zilchiopsis collastinensis P.: Protective Role of Chorion","resumen":"The lethality (LC50) of endosulfan and chlorpyrifos  is higher in adults (1990 and 156.78 lg\/L respectively)  than in embryos (95380 and 1242.54 lg\/L  respectively) of the crab Zilchiopsis collastinensis. The  thickened embryonic coat of the freshwater species might  isolate the embryo inside the egg, reducing the toxicity.  Sublethal concentrations of chlorpyrifos and endosulfan  caused an increase in hatching time and a decrease in  effective hatching (p&#65533;.05), and only the control crabs  survived until the first molt cycle. The effects of long-term  exposure should be evaluated in the offspring in addition to  the acute toxicity.","palabras_clave":"Biocides | Lethality|Effects in embryos|crab"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39516,"idioma_id":4,"titulo":"Evidences of reliability and validity of the Dispositional Envy Scale","resumen":"The emotional experience of envy goes through different cultures. However, few  instruments  have  been  developed  for  its  measurement.  Smith  et  al.  (1999) proposed  the  Dispositional  Envy  Scale  (DES),  which  has  shown  good  validity properties, stability and internal consistency in psychometric studies conducted with U.S.  and  Brazilian  samples.  This  research  aimed  at  evaluating  the  psychometric properties  of  validity  and  reliability  of  the  DES  with  samples  of  participants  from Cordoba, Argentina, university students (n = 399) and adults from general population (n  =  316).  Furthermore,  the  Psychological  Entitlement  Scale  and  the  Subjective Happiness  Scale  were  applied.  Analysis  of  exploratory  and  confirmatory  factor structure  provided  evidence  about  the  unidimensionality  of  the  scale.  Evidence  of adequate internal consistency was obtained. Besides, envy was positively related to entitlement and it was negatively related to subjective happiness.","palabras_clave":"Dispositional Envy  Scale|Psychometry|factor structure|internal consistency"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39517,"idioma_id":5,"titulo":"Visiones diacrónica y sincrónica de las normas jurídicas: consecución de fines en la interpretación jurídica y argumentación en concurrencia","resumen":"Esta revista es publicada por el Instituto de Cultura Jurídica y la&nbsp;Maestría en Sociología Jurídica de la Facultad de Ciencias Jurídicas y Sociales, UNLP. Se encuentra indizada en Latindex Directorio. Posee distribución nacional e internacional.   Resumen: Este trabajo pretende presentar una serie de ideas en torno a la variación de los sentidos normativos de las normas jurídicas generales interpretadas por los jueces a través del tiempo, es decir, en forma sincrónica. Se introduce una visión de la hermenéutica jurídica y cómo ella conduce a la producción de sentidos normativos novedosos contextualizados. Dado que estas decisiones judiciales pueden acarrear innovaciones o ratificaciones de sentido, la argumentación es necesaria como requisito legitimador frente a la comunidad jurídica y como sustentadora de la razonabilidad de la decisión tomada. Por otro lado, esta argumentación no solo incide en la aceptación por parte de los sujetos de los sentidos sino que también procura convencer y persuadir de la corrección de la interpretación como modo de asegurar la eficacia jurídica.","palabras_clave":"hermenéutica|normas jurídicas|diacronía|sincronía|argumentación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39518,"idioma_id":4,"titulo":"Non-lethal assessment of the reproductive status of broadnose sevengill sharks (Notorynchus cepedianus) to determine the significance of habitat use in coastal areas.","resumen":"Identification of the importance of habitats that are frequently used by any species is essential to a complete understanding of the species? biology and to incorporate their ecological role into conservation and management programmes. In this context, the present study investigated whether Tasmanian coastal waters have any reproductive relevance for the broadnose sevengill shark (Notorynchus cepedianus). Although this species is a large coast-associated apex predator in these areas, there is a complete gap in understanding the role that these coastal systems could play in its reproduction. Reproductive hormones were used as a non-lethal method to address the reproductive biology of this species. Females seemed to have at least a biannual reproductive cycle, being pregnant for ~1 year and spending at least 1 year non-pregnant, with the ovulatory  cycle separated from gestation. Mature females were found to be ovulating, in the initial stages of pregnancy, resting or starting a new vitellogenic cycle. Notorynchus cepedianus did not use these coastal habitats for mating or as a pupping ground. Although the mating season was distinguished between September to April, only 22% of males showed mating scars during the peak of the mating period and no near-term pregnant females were observed. Thus, despite these coastal waters being an important foraging ground for this species, these areas did not have any reproductive relevance. In consequence, future management and conservation planning programmes need to identify whether there are other areas in Tasmania that play a critical role for reproductive purposes in this species. Finally, although previous studies have linked reproductive hormones with external examination of the gonads to validate the use of steroids as a non-lethal tool to address reproduction, the present study used this methodology without killing any animals. This has important implications for conservation programmes of threatened and endangered species worldwide where the methodology cannot be validated.","palabras_clave":"Elasmobranchs|maturity|steroid hormones|viviparity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39519,"idioma_id":4,"titulo":"Ochratoxin A production by Aspergillus niger: Effect of water activity and a biopreserver formulated with Lactobacillus plantarum CRL 778","resumen":"Some filamentous fungi of the genera Aspergillus (A.) are of high impact in food safety due to the productionof a toxic secondary metabolite, the ochratoxin A (OTA). The present study was carried out toevaluate the effect water activity (aw) on the growth and the OTA production by the strain Aspergillusniger 13D both in vitro assays and in bread slices. High values of aw favoured growth and OTA productionby A. niger 13D in Czapek Yeast extract agar medium (CYA) with the optimum at 0.995. In bread slices,fungi growth rate (mmax: 0.90e1.07 cm d1) and OTA production (5.13e10.79 ng g1) were lower respectto CYA medium (mmax: 1.09e1.81 cm d1, OTA concentration: 26.02e133.28 ng g1) independently to aw.Furthermore, efficacy antifungal of biopreserver formulated with Lactobacillus plantarum CRL 778(SL778) for packed bread was evaluated. Our result evidenced the inhibitory activity of SL778 againstgrowth of ochratoxigenic A. niger 13D in bread making at different aw. In addition, this biopreserverdemonstrated is principally antimycotoxigenic, observing a reduction 60% of OTA at 0.995 and 0.971 awin bread added with SL778.","palabras_clave":"Lactobacillus|ochratoxin A|Bread"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39520,"idioma_id":4,"titulo":"The concept of citizenship: multicultural Challenges and Latin Amercian Constitutional democracy","resumen":"In Latin American multicultural societies, citizenship is defined by a normative status that allocates community status rights. Citizenship in multicultural societies is therefore determined by legal dynamics that delimitate who receives citizenship status and who is excluded from it. According to this framework, those who have citizenship rights are considered equal under the law. However, it can be argued that constitutional statements that determine notions of equality do so at a rhetorical level.&nbsp;Considering this point, one can question whether laws that provide rights to citizens with cultural differences are in fact effective if certain groups cannot fully exercise them. The substantive point that is being argued here is that although certain rights are formally granted to every citizen, pragmatically speaking, it is often the case that certain members of society are not able to exercise these rights. The point that will therefore be argued in this article is that while legal and political rights are formally granted to minority groups, administrative and social conditions make such rights unattainable to the very groups that these rights were designed to help.&nbsp;&nbsp;&nbsp;&nbsp;","palabras_clave":"ciudadanía|multiculturalismo|sentidos normativos|discurso jurídico|democracia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39521,"idioma_id":4,"titulo":"Measurements of diffusion coefficients in solids by means of LIBS combined with direct sectioning","resumen":"This work explore the application of Laser Induced Breakdown Spectroscopy (LIBS) to themeasurement of diffusion coefficientsDin solids. Different experimental set ups weretested looking for minimize the error and extend the range of Dvalues achievable. Itwas found that the combination of direct sectioning with precision grinder plus LIBS isthe best arrangement in order to fulfill these goals. Excellent agreement with previousresults in the literature, measured with standard techniques, was obtained.","palabras_clave":"LIBS|DIFFUSION|DIRECT SECTIONING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39522,"idioma_id":4,"titulo":"Phase coexistence in films composed of DLPC and DPPC: A comparison between different model membrane systems","resumen":"For the biophysical study of membranes, a variety of model systems have been used to measure the different parameters and to extract general principles concerning processes that may occur in cellular membranes. However, there are very few reports in which the results obtained with the different models have been compared. In this investigation, we quantitatively compared the phase coexistence in Langmuir monolayers, freestanding bilayers and supported films composed of a lipid mixture of DLPC and DPPC. Two-phase segregation was observed in most of the systems for a wide range of lipid proportions using fluorescence microscopy. The lipid composition of the coexisting phases was determined and the distribution coefficient of the fluorescent probe in each phase was quantified, in order to explore their thermodynamic properties.  The comparison between systems was carried out at 30 mN\/m, since it is accepted that at this or higher lateral pressures, the mean molecular area in bilayers is equivalent to that observed in monolayers.  Our study showed that while Langmuir monolayers and giant unilamellar vesicles had a similar phase behavior, supported films showed a different composition of the phases with the distribution coefficient of the fluorescent probe being close to unity. Our results suggest that, in supported membranes, the presence of the rigid substratemay have led to a stiffening of the liquid-expanded phase due to a loss in the degrees of freedom of the lipids as a consequence of the proximity of the solid material.","palabras_clave":"LIPID MIXTURES|MODEL MEMBRANES|PHASE DIAGRAM|PROBE DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39523,"idioma_id":7,"titulo":"Eredità, genealogie e memorie postcoloniali in America latina Scritture di frontiera dal Sud","resumen":"In questo testo introduttivo i quattro organizzatori del Primo Congresso di Studi Postcoloniali (Buenos Aires, 5, 6, 7  dicembre 2012) passano in rassegna alcune delle principali questioni e le linee guida che hanno attraversato le sessioni plenarie e i tavoli tematici. A partire da un serrato confronto con le categorie e le proposte epistemologiche elaborate   nell ambito degli studi postcoloniali e del femminismo decoloniale, il congresso raccoglie la sfida di avviare un dialogo Sud\/Sud attraverso il consolidamento di uno spazio di discussione interdisciplinare nei distinti campi teorici che indagano l?esperienza della postcolonialità.Indexada en: : Academia.edu, DOAJ, ACNP, BASE, Google Scholar, JournalTOCs, JURN, PLEIADI.","palabras_clave":"POSCOLONIALISMO|POSCOLONIALIDAD|FEMINISMOS|DIALOGO SUR\/SUR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39524,"idioma_id":4,"titulo":"A Double-Hit Model of Stress Dysregulation in Rats: Implications for Limbic Corticosteroid Receptors and Anxious Behavior Under Amitriptyline Treatment","resumen":"Adversity during early life can lead to diverging endocrine and behavioral responses to stress in adulthood. In our laboratory, we evaluated the long-term effects of early life adversity and its interaction with chronic stress during adulthood. We propose this as a model of vulnerability to dysregulation of the stress response. We hypothesized that rats subjected to both protocols would show differential expression of corticosteroid receptors measured as number of neurons immunoreactive for glucocorticoid receptors (GR) or mineralocorticoid receptors (MR), in limbic areas related to the control of anxiety-like behavior. We also evaluated the effect of amitriptyline expecting to prevent the outcomes of the model. Male Wistar rats were separated from the mother (MS) for 4.5&#8201;h every day for the first 3 weeks of life. From postnatal day 50, rats were subjected to chronic variable stress (CVS) during 24&#8201;d (five types of stressor at different times of day). During the stress protocol, the rats were administered amitriptyline (10&#8201;mg\/kg i.p.) daily. MS evoked lower MR expression in the central amygdaloid nucleus and this was reversed by amitriptyline. Furthermore, CVS increased MR immunoreactivity in the hippocampal area CA2 and increased anxious behavior; both effects were prevented by the antidepressant. When MS was combined with CVS during adulthood, there was a reduction of locomotor activity, with no corrective effect of amitriptyline. The differential effects among groups could mean that MS would promote an alternative phenotype that is expressed when facing CVS (a double hit) later in life.","palabras_clave":"GLUCOCORTICOIDS|RECEPTORS|LIMBIC SYSTEM|STRESS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39525,"idioma_id":4,"titulo":"On the Design and Analysis of Fair Contact Plans in Predictable Delay-Tolerant Networks","resumen":"Delay-tolerant networks (DTNs) have become a promising architecture for wireless sensor systems in challenged communication environments where traditional solutions based on persistent connectivity either fail or show serious weaknesses. As a result, different routing schemes have been investigated that take into account the time-evolving nature of the network topology. Among them, contact graph routing has been proposed for space environments with predictable connectivity. In order to evaluate routing decisions, DTN nodes need to know the contact plan in advance, which comprises all communication links among nodes that will be available in the future. Since not all potential contacts can belong to the contact plan, its design requires analyzing conflicting contacts in order to select those that meet an overall goal. In this paper, we consider the design of contact plans that can maximize fairness requirements while still maximizing the overall capacity as well. To this end, we propose to formalize the problem by means of an optimization model and evaluate its performance in terms of different fairness metrics. Since this model can be computationally intractable for a large number of contacts, we also propose to tackle it as a matching problem, resulting in algorithms of polynomial complexity, and compare these results with those of the original model. We show that fairness can be properly modeled to design contact plans and that efficient algorithms do exist to compute these plans quite accurately while also improving overall network routing metrics for a proposed case study.","palabras_clave":"DELAY TOLERANT NETWORKS|NETWORK ROUTING|NETWORK TOPOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39526,"idioma_id":4,"titulo":"Basin-Wide Oceanographic Array Bridges the South Atlantic","resumen":"The Meridional Overturning Circulation (MOC) is a global system of surface, intermediate and deep ocean currents. It is the primary mechanism for transporting heat, freshwater and carbon between ocean basins and connects the surface layer of the ocean and atmosphere with the huge reservoir of the deep sea. Climate models show that past changes in the strength of the MOC were linked to climate variations with further predictions hinting that the MOC will continue to modulate future climate change scenarios on time-scales ranging from decades to centuries [Latif et al., 2006]. At present only one monitoring system of the MOC, the RAPID-MOC\/MOCHA\/Western Boundary Time Series extends across the North Atlantic along 26.5°N, with preliminary results suggesting that the strength of the overturning circulation varies considerably [Rayner et al., 2011]. Given the complexity of the MOC, a more comprehensive observing system extending betweenneighbouring ocean basins is needed. A recent article [Schiermeier, 2013] identified 34.5°S in the South Atlantic as crucial to examining how inter-ocean exchange influences the MOC. Recognition of this critical importance led to the creation of the South Atlantic MOC (SAMOC) initiative [Garzoli et al., 2010]. SAMOC includes a trans-basin mooring line along 34.5°S, the South Atlantic MOC Basin-wide Array (SAMBA), aimed at monitoring long-term physical-chemical changes within the western and eastern boundary current systems, and the impact of inter-ocean exchange (Figure 1).","palabras_clave":"CIRCULACION MERIDIONAL DEL OCEANO|ATLANTICO SUR|CORRIENTES MARINAS|OBSERVACIONES OCEANICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39527,"idioma_id":4,"titulo":"Influence of a lactobacillus probiotic strain on the intestinal ecosystem in a stress model in mouse","resumen":"Daily exposure to stressful situations affects the health of humans and animals. It has been shown that psychological stress affects the immune system and can exacerbate diseases. Probiotics can act as biological immunomodulators in healthy people, increasing both intestinal and systemic immune responses.  The use of probiotics in stress situations may aid in reinforcing the immune system.  The aim of this study was to evaluate the effect of a probiotic bacterium on the gut immune system of mice that were exposed to an experimental model of stress induced by food and mobility restriction. The current study focused on immune cells associated with the lamina propria of the intestine, including CD4+ and CD8+ T lymphocytes, CD11b+ macrophages, CD11c+ dendritic cells, and IgA+ B lymphocytes, as well as the concentrations of secretory IgA (S-IgA) and cytokine interferon gamma (INF-gamma in  intestinal fluid. We also evaluated the probiotic?s influence on the gut microbiota.  Probiotic administration increased IgA producing cells, CD4+ cells in the lamina propria of the small intestine, and S-IgA in the lumen; it also reduced the levels of IFN-gamma that had increased during stress and improved the intestinal microbiota as measured by an increase in the lactobacilli population.  The results obtained from administration of the probiotic to stressed mice suggest that the use of food containing these microorganisms may work as a palliative to reinforce the immune system.","palabras_clave":"STRESS|PROBIOTICS|INTESTINAL MICROBIOTA|IGA PRODUCING CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39528,"idioma_id":4,"titulo":"Evaluation of structural shrinkage on freeze-dried fruits by image analysis: Effect of relative humidity and heat treatment","resumen":"Stability of many dehydrated systems is related to the formation of a glass during drying. Highly porous materials, such as those prepared by freeze-drying are susceptible to shrinkage post-drying when stored at not optimal conditions. The aim of this study was to evaluate the occurrence of structural shrinkage on freeze-dried fruits through image analysis in relation to relative humidity (RH) and heat treatment. Freeze-dried fruits were humidified between 11 and 84 % RH at 25 °C for 14 days, and then stored at 45 °C. Sugar and water content, thermal transitions, and volume changes were determined. The shrinkage degree of fresh, lyophilized, humidified, and heat-treated samples was assessed by image analysis. The freeze-drying process did not produce important changes on fruits volume. At low RH values (11-22 % RH), the reduction of the cylinders volume was lower than 15 %. The maximum shrinkage values at each RH were attained in the initial period of humidification (first and second days), and then shrinkage rate decreased markedly, reaching a nearly constant value. The shrinkage degree increased with the increase in RH, reaching values up to 60 % volume reduction. During heat treatment, the volume reduction was less than 10 %. The shrinkage degree was limited by the structural characteristics of the fruits. The structural changes were strongly influenced by variables such as water content, glass transition temperatures, and storage time. In this work, the degree of shrinkage could be followed by image analysis and the use of a mechanical modeling software. © 2013 Springer Science+Business Media New York.","palabras_clave":"Dehydrated fruits|shrinkage|Freeze-drying|Glass transition"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39529,"idioma_id":4,"titulo":"Proton mobility for the description of dynamic aspects of freeze-dried fruits","resumen":"The partitioning of water sorption isotherms into different zones, according to the strength of water interactions with solids has very important practical applications. However, the dynamic properties of water play an important role in complementing the information provided by water sorption isotherms. One of the most successful techniques used to prove the dynamic behavior of water in foods systems is pulsed NMR. The aim of this study was to apply the concept of proton mobility in order to better define the water-related dynamic aspects of freeze-dried fruits. Different water mobility populations were defined through 1H NMR transversal relaxation times, obtained after the application of several pulses sequences. The water content limits at which proton populations with different mobility appeared, allowed a more complete and precise description of water behavior at the different sorption stages than the parameters obtained by the application of sorption mathematical models. © 2013 Published by Elsevier Ltd.","palabras_clave":"Water sorption isotherm|Molecular mobility|LF-RMN|D´Arcy Watt"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39530,"idioma_id":4,"titulo":"New insights in the use of trehalose and modified starches for the encapsulation of orange essential oil","resumen":"During the encapsulation of aromas by spray-drying, some volatile components may be lost; consequently, the sensory profile could be modified in the final product. Therefore, the selection of the carrier matrix for the encapsulation is crucial to obtain high aroma retention and long shelf life stability, regarding aroma oxidation and physical stability of the powder. With the aim of studying the use of trehalose for the encapsulation of orange essential oil, emulsions were prepared containing mixtures of trehalose-maltodextrin (TMD) and sucrose-maltodextrin (SMD). Two modified starches were used as emulsifiers. The emulsions were spray-dried and stored at 25 and 37 °C.  The aroma retention was evaluated using Head Space-Solid Phase Microextraction \/Gas Chromatography-Mass Spectrometry (HS-SPME\/GC-MS) and by sensory evaluation. In addition, some physical properties of orange essential oil powders such as water sorption and glass transition temperature (Tg) were determined. The sensory profiles obtained for TMD and SMD were very different: TMD formulations retained mainly limonene, while SMD retained mostly alpha-pinene and myrcene. The modified starches (Capsul and Hi Cap) used as emulsifiers also affected the retention  of certain volatiles. Therefore, the selection of components in the carrier matrix is relevant to the retention of aromas in orange oil powders. Regarding the physical properties, TMD formulations presented better characteristics in comparison to SMD, particularly due to the higher Tg values. The high aroma retention levels and the good physical characteristics are promising results in relation to the inclusion of the developed formulations in dehydrated citric juices.","palabras_clave":"Orange essential oil,|Encapsulation|Trehalose|Sensory"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39531,"idioma_id":4,"titulo":"Galectin-8: a matricellular lectin with key roles in angiogenesis","resumen":"Galectin-8 (gal-8) is a tandem-repeat-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. Gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, endothelial cell migration, and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular endothelial cells. Other related gal-8 functions are also summarized here including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis.","palabras_clave":"GALECTINA-8|ENDOTELIO|ANGIOGENESIS|CD166"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39532,"idioma_id":4,"titulo":"Presence of OXA-Type Enzymes in Achromobacter insuavis and A. dolens","resumen":"The accurate species identification of Achromobacter isolates is difficult and the clinical isolates of this genus are mostly referred as A. xylosoxidans. Here, we report new OXA variants in 2 isolates identified as A. insuavis (A114, A79) and 1 isolate identified as A. dolens (A336). These results suggest that different bla OXA genes are ubiquitous in the different species of Achromobacter spp. The role of the other species of Achromobacter in clinical samples needs to be reevaluated, and the proper identification is absolutely necessary to understand the epidemiology of this genus","palabras_clave":"OXA TYPE ENZIMES|ACHOMOBACTER INSUAVIS|ACHROMOBACTER DOLENS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39533,"idioma_id":4,"titulo":"A bla VIM-2 Plasmid Disseminating in Extensively Drug-Resistant Clinical Pseudomonas aeruginosa and Serratia marcescens Isolates","resumen":"Infections caused by carbapenem-resistant Enterobacteriaceae isolates are an issue of major global concern (1). Genes coding for metallo-&#946;-lactamases (M&#946;Ls) identified in clinical isolates are associated with mobile elements and subject to horizontal genetic transfer (HGT) events (2,?6). VIM-2 is present on numerous plasmids, but only pNOR-2000 from Pseudomonas aeruginosa COL-1 from France (7, 8) and pLD209 from Pseudomonas putida LD209 from Argentina (9) have been completely sequenced. Here, we report the complete sequence and characterization of plasmid pDCPR1 harboring a blaVIM-2 gene cassette in a Tn402-type class 1 integron, which was isolated from two extensively drug-resistant strains: P. aeruginosa 802 (from a burn patient at the Hospital Municipal de Quemados, Argentina, 2005) and S. marcescens 68313 (Sanatorio Sagrado Corazón, Argentina, 2012).","palabras_clave":"Drug-Resistant|carbapenem|S. marcescens|P. aeruginosa"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39534,"idioma_id":4,"titulo":"Tailoring Doxorubicin sustainable release from biopolymeric smart matrix by Congo Red as molecular helper","resumen":"Doxorubicin (Dox) was co-encapsulated with Congo Red (CR) in order to increase drug encapsulation and sustain the release from gel microbeads composed of Alginate-Carboxy Methyl Guar Gum (68\/32) for oral controlled delivery. No release of both cargo molecules from the microbeads at pH 1.2 in 90 minutes was detected. However, 62 % CR and 16 % Dox were released from the gels at pH 7.4 at 37 °C in 8 hours when both the cargo molecules are alone. Presence of CR in the formulation reduces in about 25-30 % the release of Dox under the same experimental conditions. Rheological properties of the formulations have been investigated at different temperatures between 20 and 37 ºC. Shear thinning behavior was observed by steady-shear flow experiments for all of them and no yield stress was observed for any of the formulations. The temperature effect on Alg-CMGG-Dox-CR evidenced a synergic action between Dox and CR. Dynamic frequency sweep tests were performed to study the viscoelastic properties of the formulations. The patterns observed for Alg-CMGG indicated physical gel characteristics; however all other formulations showed a typical behavior of concentrated solutions. These results are confirming the interaction of Dox and CR and the positive effect on sustainable release in oral delivery.","palabras_clave":"BIOPOLYMERS|CONTROLLED RELEASE|DOXORUBICIN|CONGO RED"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39535,"idioma_id":4,"titulo":"Effect of the electrolyte composition on the response of a TiO2|CdS-Based Photoanode","resumen":"Sulfide solutions are the most widely selected electrolyte for the photoelectrochemical characterization of metal chalcogenide (like CdS and CdSe) based solar cells because its good hole scavenging properties and improved stabilization of the semiconductor sensitizer. However, the photocurrent values of CdS sensitized TiO2 photoanodes depend on the sodium sulfide analytical concentration and pH values in the electrolyte solution. In this report, we show that the mass transport of the sulfide hole scavenger is the main limiting process and if its concentration is lower than the HO&#8722; concentration there is a competition for adsorption sites onto TiO2 surface, decreasing the photocurrent value. A careful optimization of these two variables it is necessary in order to attaining high overall photoelectrochemical cell efficiency.","palabras_clave":"Sulfide|Solar cell|Optical sensitization|TiO2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39536,"idioma_id":4,"titulo":"Immunogenicity of hypothetical highly conserved proteins as novel antigens in Anaplasma marginale","resumen":"Anaplasma marginale is a tick-transmitted gram-negative intraerythrocytic bacterium and the etiological agent of bovine Anaplasmosis. Even though considerable research efforts have been undertaken, Anaplasmosis vaccine development remains a challenging field. Outer membrane specific antigens responsible for the ability of more complex immunogens could have a significant role in the protective response. Thus, the identification of outer membrane antigens represents a major goal in the development of bacterial vaccines. Considering that 40% of the annotated proteins in Anaplasma marginale remain as hypothetical, we selected three candidate antigens, AM1108, AM127 and AM216 based on experimental evidence, in silico structure prediction of &#946;-barrel outer membrane and orthology clustering. Sequence alignment and analysis demonstrated a high degree of conservation for the three proteins between the isolates from Argentina compared to the American strains. We confirmed the transcription of the three genes in the intraerythrocytic stage. AM1108 and AM216 recombinant proteins elicited specific T-cell response proliferation and a significant rise in TNF-&#945; and IFN-&#947; transcript levels, respectively. Only AM1108 was able to be recognized by specific antibodies from infected bovines. This study allowed the identification of new candidate components of the outer membrane fraction of A. marginale. Further studies will be required to analyze their potential as effective antigens for being included in rational vaccine strategies.","palabras_clave":"A. marginale|membrane proteins|immunogenecity|vaccines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39537,"idioma_id":4,"titulo":"Simultaneous bioremediation of Cr(VI) and lindane in soil by actinobacteria","resumen":"Environments co-contaminated with metals and organic compounds are difficult to remediate. Actinobacteria is an important group of microorganisms found in soils, with high metabolic versatility and potential for bioremediation. In this paper, actinobacteria were used to remediate soil co-contaminated with Cr(VI) and lindane. Five actinobacteria, tolerant to Cr(VI) and lindane mixture were selected: Streptomyces spp. A5, A11, M7, and MC1 and Amycolatopsis tucumanensis DSM 45259. Sterilized soil samples were inoculated with actinobacteria strains, either individually or as a consortium and contaminated with Cr(VI) and lindane, either immediately or after 7 days of growth, and incubated at 30 ºC during 14 days. All actinobacteria were able to grow and remove both contaminants, the consortium formed by Streptomyces spp. A5, M7, MC1 and A. tucumanensis showed the highest Cr(VI) removal, while Streptomyces sp. M7 produced the maximum lindane removal. In non-sterile soil samples, Streptomyces sp. M7 and the consortium removed more than 40% of the lindane, while Streptomyces sp. M7 demonstrated the greatest Cr(VI) removal. The most appropriate strategy for bioremediation of Cr(VI) and lindane co-contaminated soils would be the inoculation with Streptomyces sp. M7. These results represent the first report on successful bioremediation of soils contaminated simultaneously with Cr(VI) and lindane.","palabras_clave":"BIOREMEDIATION|CR(VI)|LINDANE|SOIL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39538,"idioma_id":5,"titulo":"RECURSOS Y DIETAS HUMANAS EN LAGUNA LLANCANELO (MENDOZA; NORDPATAGONIA): UNA DISCUSIÓN ISOTÓPICA DEL REGISTRO ARQUEOLÓGICO","resumen":"Este estudio intenta a mejorar el conocimiento arqueológico de Llancanelo, un humedal desarrollado en nordpatagonia entre los desiertos del Monte y Patagonia. Se parte de la intención por comprender si en Llancanelo se desarrollaron estrategias humanas diferenciales al resto de la región, el sur de Mendoza, o dicho lugar formó, para los grupos humanos, parte integral de los otros ambientes. En ese contexto este trabajo intenta caracterizar la dieta humana mediante los isótopos estables. Así se presenta resultados de estos análisis (&#948;13C y &#948;15N en colágeno y &#948;13C y &#948;18O en hidroxiapatita) que se discuten en primer lugar con la ecología isotópica generada para esta zona. Luego se comparan estas tendencias con las generadas por el modelo de mezcla isotópica aplicando el software SISUS y finalmente comparando esto con el registro zooarqueológico de Llancanelo. En esta escala los resultados muestran una significativa variabilidad tanto en isótopos humanos como en registro de fauna que podrían segregarse en las tendencias del sector Norte y sector Oeste. Aún así hay similares tendencias en el humedal: isótopos y fauna señalarían una baja importancia de guanaco y reidos, y una mediana importancia de recursos acuáticos y animales terrestres pequeños. A pesar de no haber aun registro que lo confirmen, los isótopos simulados por SISUS proponen una fuerte explotación de algarrobos.  El conjunto humano Llancanelo no muestra diferencias significativas con el resto de las muestras humanas del sur de Mendoza, pero analizadas por sector, el Oeste tiene mayor similitud a las dietas isotópicas de Payunia\/Planicies Orientales y las del Norte con las de Piedemonte. Sobre esta base se propone a Llancanelo como un sector de convergencia poblacional y que fue explotada complementariamente con otras áreas del sur de Mendoza.","palabras_clave":"Isotopos estables|Humedal|dieta humana|Nord patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39539,"idioma_id":4,"titulo":"Responses of Phalaris canariensis L. Exposed to Commercial Fuels during Growth","resumen":"The growth behaviour of canary grass (Phalaris canariensis L) when cultivated in presence of farming fuels is reported in this work. P. canariensis L. is relevant in several countries. It is an emergent plant for phytoremediation and biofuel activities. The following variables: root length, stem length, total plant weight, green tissue weight (tiller, leaf), total chlorophyll and chlorophyll a\/b ratio, were monitored during the growth in presence of commercial fuels (premium grade, regular grade, diesel and kerosene) at different concentrations. We applied a comprehensive statistical analysis to understand the results: Univariate analysis, factorial analysis of variance and subsequent Tukey test were applied to the variables to assess the significance of the differences found. The normality of these variables was analyzed with the Shapiro Wilks test. All parameters were affected by all type and concentrations of fuels and its interaction. This is one of the first reported cases which describe the responses of the growth parameters from canary grass when cultivated in presence of persistent contamination of farming fuels.  grass when cutivated in presence of an essentially constant concentration of farming fuels","palabras_clave":"Phanaris canariensis|hydrocarbon contamination|remediation|fuel spills"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39540,"idioma_id":4,"titulo":"Argentophilic nucleolus organizer region as a proliferation marker in cervical intraepithelial neoplasia grade 1 of the uterine cervix","resumen":"AIM:  p16INK4a and argentophilic nucleolus organizer region (AgNOR) can be used as markers for progression of cervical intraepithelial neoplasia grade 1 (CIN1) of the uterine cervix. Our objective was to study the predictive value of the AgNOR technique as a progression marker of CIN1 and its correlation with p16INK4A.  MATERIAL AND METHODS:  One uterine cervix biopsy from each of 75 patients with diagnosis of CIN1 was selected. All of these patients underwent a second biopsy, and these were also used for the study.  RESULTS:  The second biopsies showed: regression (20 patients), persistent CIN1 (38 patients), progression to CIN2 (10 patients) and progression to CIN3 (seven patients). p16INK4A showed reactivity in 67 of the 75 first CIN1 biopsies: 12 of the 20 cases that cleared the lesions and the 55 cases with persistent or progressive lesions were positive for p16INK4a (specificity: 40%; sensitivity: 100%; positive predictive value [PPV]: 82%; negative predictive value [NPV]: 100%). Samples with AgNOR areas less than 3.0 &#956;(2) returned in all cases, but patients whose lesions persisted or progressed to CIN2\/CIN3, showed AgNOR areas greater than 3.0&#8201;&#956;(2) in 50\/55 cases (specificity: 100%; sensitivity: 91%; PPV: 100%; NPV: 80%).  CONCLUSIONS:  p16INK4a is expressed in a high percentage of returning lesions. AgNOR might be a better marker of proliferation of CIN1 than p16INK4a (PPV&#8201;=&#8201;100%), which means that a value greater than 3.0&#8201;&#956;(2) indicates the persistence or progression of the lesion. As its NPV is 80%, a value of AgNOR area less than 3.0&#8201;&#956;(2) in CIN1 leaves a margin of doubt about the future behavior of the lesion.","palabras_clave":"Cervical Cancer|proliferation marker|p16|HPV"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39541,"idioma_id":4,"titulo":"Cysteine-rich positions outside the structural zinc motif of human papillomavirus e7 provide conformational modulation and suggest functional redox roles","resumen":"The E7 protein from high-risk human papillomavirus is essential for cell transformation in cervical, oropharyngeal, and other HPV-related cancers, mainly through the inactivation of the retinoblastoma (Rb) tumor suppressor. Its high cysteine content (~7%) and the observation that HPV-transformed cells are under oxidative stress prompted us to investigate the redox properties of the HPV16 E7 protein under biologically compatible oxidative conditions. The seven cysteines in HPV16 E7 remain reduced in conditions resembling the basal reduced state of a cell. However, under oxidative stress, a stable disulfide bridge forms between cysteines 59 and 68. Residue 59 has a protective effect on the other cysteines, and its mutation leads to an overall increase in the oxidation propensity of E7, including cysteine 24 central to the Rb binding motif. Gluthationylation of Cys 24 abolishes Rb binding, which is reversibly recovered upon reduction. Cysteines 59 and 68 are located 18.6 Å apart, and the formation of the disulfide bridge leads to a large structural rearrangement while retaining strong Zn association. These conformational and covalent changes are fully reversible upon restoration of the reductive environment. In addition, this is the first evidence of an interaction between the N-terminal intrinsically disordered and the C-terminal globular domains, known to be highly and separately conserved among human papillomaviruses. The significant conservation of such noncanonical cysteines in HPV E7 proteins leads us to propose a functional redox activity. Such an activity adds to the previously discovered chaperone activity of E7 and supports the picture of a moonlighting pathological role of this paradigmatic viral oncoprotein","palabras_clave":"CYSTEINE|PAPILLOMAVIRUS|E7|REDOX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39542,"idioma_id":4,"titulo":"Search for Invisible Decays of a Higgs Boson Produced in Association with a Z Boson in ATLAS","resumen":"A search for evidence of invisible-particle decay modes of a Higgs boson produced in associationwith a Z boson at the Large Hadron Collider is presented. No deviation from the Standard Modelexpectation is observed in 4.5 fb&#8722;1 (20.3 fb&#8722;1 ) of 7 (8) TeV pp collision data collected by the ATLASexperiment. Assuming the Standard Model rate for ZH production, an upper limit of 75%, at the 95%confidence level is set on the branching ratio to invisible-particle decay modes of the Higgs boson ata mass of 125.5 GeV. The limit on the branching ratio is also interpreted in terms of an upper limit onthe allowed dark matter?nucleon scattering cross section within a Higgs-portal dark matter scenario.Limits are also set on an additional neutral Higgs boson, in the mass range 110 &lt; mH &lt; 400 GeV,produced in association with a Z boson and decaying to invisible particles.","palabras_clave":"ATLAS|PARTICLE|PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39543,"idioma_id":4,"titulo":"The differential production cross section of the phi(1020) meson in sqrt(s)=7 TeV pp collisions measured with the ATLAS detector","resumen":"A measurement is presented of the &#966; &#8594; K + K &#8722; production cross section at s = 7 TeV usingpp collision data corresponding to an integrated luminosity of 383 &#956;b&#8722;1 , collected with the ATLASexperiment at the LHC. Selection of &#966;(1020) mesons is based on the identification of charged kaonsby their energy loss in the pixel detector. The differential cross section is measured as a function of thetransverse momentum, pT,&#966; , and rapidity, y&#966; , of the &#966;(1020) meson in the fiducial region 500 &lt; pT,&#966; &lt;1200 MeV, |y&#966; | &lt; 0.8, kaon pT,K &gt; 230 MeV and kaon momentum pK &lt; 800 MeV. The integrated&#966;(1020)-meson production cross section in this fiducial range is measured to be &#963;&#966;&#8594;K + K &#8722; = 570 ± 8(stat) ± 66 (syst) ± 20 (lumi) &#956;b.","palabras_clave":"ATLAS|PARTICLE|PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39544,"idioma_id":4,"titulo":"Combined toxicological effects of pesticides: A fish multi-biomarker approach","resumen":"The combined effects of two synthetic insecticides on a wide array of biomarkers in the freshwaterfish Piaractus mesopotamicus were studied. Fish were exposed to sublethal concentrations of endosul-fan (ED), lambda-cyhalothrin (LC), and the combination of both pesticides for 96 h. The set of analyzedbiomarkers included morphometric and hematological parameters, transaminases and alkaline phos-phatase activities, antioxidant enzymes activities and oxidative damage biomarkers measured in gills,liver, kidney, brain and muscle. According to the principal component analysis, the most significant effectswere produced by the ED?LC combination. So, the mixture of both insecticides produced an increase inthe liver-somatic index, hematological changes related to immunological biomarkers (increased whiteblood cells count, and alterations in the differential leukocytes count), decreased liver transaminasesactivity, antioxidant enzymes induction in almost every tissue, and lipid peroxidation levels increases inliver, kidney and brain of exposed fish. Our results suggest deleterious effects of ED and LC insecticidesin combination, and support the usefulness of the multi-biomarker approach for the characterization oftoxicological mechanisms induced by pesticides.","palabras_clave":"ENDOSULFAN|LAMBDA-CYHALOTHRIN|MULTIPLE BIOMARKERS|PIARACTUS MESOPOTAMICUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39545,"idioma_id":4,"titulo":"Influence of the chemical composition on the ausferritic transformation in carbide-free bainitic cast steel","resumen":"This work focuses on the study of the solid state transformations that   take place during the austempering of high silicon carbide-free bainitic   cast steels with different chemical composition. In order to get this   objective three cast steel melts with different chemical compositions   were produced, evaluating the influence of Cr, Mn, Ni, Al and Co. For   each of these steels, samples were subjected to an austempering heat   treatment at 340 oC varying the austempering time from 5 sec to 120 sec.   The results show that small regions of free ferrite were obtained   during continuous cooling from the austenitising to the austempering   temperatures in unalloyed high silicon cast steels. At short   austempering time (5 sec), the presence of a small fraction of   ausferrite was observed. Austempering for 60 sec showed a larger amount   of ausferrite. However, the ausferritic reaction is incomplete, and some   martensite also was present, mainly located in last to freeze (LTF)   zones. After an austempering of 120 sec, a fully ausferritic matrix was   obtained. The addition of Cr and Mo avoided the initial precipitation of   free ferrite, and lowered the isothermal transformation kinetics. On   the other hand the use of Al and Co increase the presence of ferrite   formed during continuous cooling and accelerates the kinetics of the   ausferritic reaction.","palabras_clave":"bainitic steel|cast|chemical composition|carbide free|high silicon"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39546,"idioma_id":4,"titulo":"A Long-Chain Flavodoxin Protects Pseudomonas aeruginosa from Oxidative Stress and Host Bacterial Clearance","resumen":"Long-chain flavodoxins, ubiquitous electron shuttles containing flavin mononucleotide (FMN) as prosthetic group, play an important protective role against reactive oxygen species (ROS) in various microorganisms. Pseudomonas aeruginosa is an opportunistic pathogen which frequently has to face ROS toxicity in the environment as well as within the host. We  identified a single ORF, hereafter referred to as fldP (for flavodoxin from P. aeruginosa), displaying the highest similarity in length, equence identity and predicted secondary structure with typical long-chain flavodoxins. The gene was cloned and expressed in Escherichia coli. The recombinant product (FldP) could bind FMN and exhibited flavodoxin  activity in vitro. Expression of fldP in P. aeruginosa was induced by oxidative stress conditions through an OxyR-independent mechanism, and an fldP-null mutant accumulated higher intracellular ROS levels and exhibited decreased tolerance to H2O2 toxicity compared to wild-type siblings. The mutant phenotype could be complemented by expression of a cyanobacterial flavodoxin. Overexpression of FldP in a mutT-deficient P. aeruginosa strain decreased H2O2-induced cell death and the hypermutability caused by DNA oxidative damage. FldP contributed to the survival of P. aeruginosa within cultured mammalian macrophages and in infected Drosophila melanogaster, which led in turn to accelerated death of the flies. Interestingly, the fldP gene is present in some but not all P. aeruginosa strains, constituting a component of the P. aeruginosa accessory genome. It is located in a genomic island as part of a self-regulated polycistronic operon containing a suite of stress-associated genes. The collected results indicate that the fldP gene encodes a long-chain flavodoxin, which protects the cell from oxidative stress, thereby expanding the capabilities of P. aeruginosa to thrive in hostile  environments.","palabras_clave":"FLAVODOXIN|PSEUDOMONAS|OXIDATIVE STRESS|HYPERMUTABILITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39547,"idioma_id":4,"titulo":"Multiscale recognition of legume varieties based on leaf venation images","resumen":"In this work we propose an automatic low cost procedure aimed at classifying legume species and varieties based exclusively on the characterization and analysis of the leaf venation network. The identification of leaf venation patterns which are characteristic for each species or variety is not an easy task since in some situations (specially for cultivars from the same species) the vein differences are visually indistinguishable for humans. The proposed procedure takes as input leaf images acquired using a standard scanner, processes the images in order to segment the veins at different scales, and measures different traits on them. We use these features in combination with modern automatic classifiers and feature selection techniques in order to perform recognition. The process was initially applied to recognize three different legumes in order to evaluate the improvements over previous works in the literature, and then it was employed to distinguish three diverse soybean cultivars. The results show the improvements achieved by the usage of the multiscale features. The cultivar recognition is a more challenging problem, since the experts can not distinguish evident differences in plain sight. However, we achieve acceptable classification results. We also analyze the feature relevance and identify, for each classifier, a small set of distinctive traits to differentiate the species and varieties.","palabras_clave":"IMAGE CLASSIFICATION |IMAGE ANALYSIS|CULTIVARS RECOGNITION|MULTISCALE VEINS IMAGES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39548,"idioma_id":4,"titulo":"Innervation of amphibian reproductive system. Histological and ultrastructural studies","resumen":"Abstract&nbsp;      In the present study we describe for the first time   in anuran amphibians the histological and ultrastructural   characteristics of innervation in the female reproductive organs. The   observations in Rhinella arenarum revealed the presence of nerve   fibers located predominantly in the ovarian hilium and in the oviduct   wall. In both organs the nerves fibers are placed near blood vessels and   smooth muscles fibers. In the present study the histological   observations were confirmed using antibodies against peripherin and   neurofilament 200 proteins. Ultrastructural analyses demonstrated that   the innervation of the reproductive organs is constituted by   unmyelinated nerve fibers surrounded by Schwann cells. Axon terminals   contain a population of small, clear, translucent vesicles that coexist   with a few dense cored vesicles.      The ultrastructural   characteristics together with the immunopositive reaction to tyrosine   hydroxylase of the nerve fibers and the type of synaptic vesicles   present in the axon terminal would indicate that the reproductive organs   of R. arenarum females are innervated by the sympathetic division of the autonomic nervous system.","palabras_clave":"AMPHIBIAN|OVARY|OVIDUCT|INNERVATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39549,"idioma_id":4,"titulo":"Hydrostatic pressure to trigger and assist magnetic transitions: Baromagnetic refrigeration","resumen":"The possible application of the barocaloric effect to produce solid state refrigerators is a topic of interest in the field of applied physics. In this work, we present experimental data about the influence of external pressure on the magnetic properties of a manganite with phase separation. Using the Jahn Teller effect associated with the presence of the charge ordering, we were able to follow the transition to the ferromagnetic state induced by pressure. We also demonstrated that external pressure can assist the ferromagnetic state, decreasing the magnetic field necessary to generate the magnetic transition.","palabras_clave":"Magnetocaloric|Barocaloric|Manganite"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39550,"idioma_id":5,"titulo":"Parámetros reproductivos de Hypsiboas punctatus (Schneider 1799) (Anura: Hylidae) en el extremo sur de su área de distribución","resumen":"Hypsiboas punctatus (Schneider 1799) posee una amplia distribución en Sudamérica, a lo largo de un gradiente ambiental y latitudinal (tropical\/templado), por lo que las condiciones que enfrentan sus poblaciones difieren significativamente. Hasta el momento, solamente se conocen los parámetros reproductivos de esta especie en regiones tropicales, por lo que en el presente trabajo se estudió una población de una región templada para evaluar si existen diferencias. Los individuos estudiados resultaron ser de menor tamaño que los de poblaciones tropicales. El tamaño y peso de los machos no se correlacionaron con el volumen testicular. En cambio, el tamaño y el peso de las hembras se correlacionaron positivamente con su fertilidad. No se encontraron cuerpos grasos desarrollados en las hembras pero sí en los machos. Los resultados obtenidos sugieren que existe una variabilidad en los parámetros reproductivos de H. punctatus que puede estar relacionada tanto a un fenómeno de plasticidad fenotípica como de diferenciación genética entre poblaciones distantes. Esto sería una de las claves que permitiría a esta especie prosperar en diferentes ecosistemas con distintas características y presiones ambientales","palabras_clave":"HYPSIBOAS PUNCTATUS|PARÁMETROS REPRODUCTIVOS|VARIABILIDAD DE CARACTERES DE HISTORIA DE VIDA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39551,"idioma_id":4,"titulo":"Soybean flour induces a greater increase of the antioxidant defenses in rats fed with normocaloric diet compared with hypercaloric diet","resumen":"Soybeans, due to their antioxidant properties, present beneficial health effects. The objective was to evaluate if replacing casein with soy flour, modifies antioxidant defenses in rat liver, compared to animals that continued being fed with casein based diets (normocaloric and hypercaloric).  RESULTS:  Four groups of rats were used: CC (control casein), CS (control soy), HC (hypercaloric casein) and HS (hypercaloric soy). Malondialdehyde, in serum and liver, did not present differences. In liver, when comparing CS vs. CC: increased superoxide dismutase 1 (P&#8201;<&#8201;0.001), catalase (P&#8201;<&#8201;0.01) and glutathione reductase (P&#8201;<&#8201;0.05) activities, the total glutathione (P&#8201;<&#8201;0.001) and reduced glutathione (P&#8201;<&#8201;0.05) content and decreased oxidized glutathione content (P&#8201;<&#8201;0.05). In HS vs. HC: increased carbonyl groups (P&#8201;<&#8201;0.01) and superoxide dismutase 1 activity (P&#8201;<&#8201;0.05), and decreased glutathione peroxidase activity (P&#8201;<&#8201;0.01), total glutathione (P&#8201;<&#8201;0.05) and oxidized glutathione content (P&#8201;<&#8201;0.001). In HS vs. CS: decreased glutathione reductase activity (P&#8201;<&#8201;0.01), total glutathione (P&#8201;<&#8201;0.001) and reduced glutathione (P&#8201;<&#8201;0.01) content, and increased oxidized glutathione content (P&#8201;<&#8201;0.05).  CONCLUSION:  Replacing casein by soybean flour improves antioxidant defenses, mainly in normocaloric diets.  This article is protected by copyright. All rights reserved.","palabras_clave":"antioxidant defenses|hypercaloric diet| rat liver|reactive oxygen species;"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39552,"idioma_id":4,"titulo":"Search for Higgs boson decays to a photon and a Z boson in pp collisions at s&#8730; = 7 and 8 TeV with the ATLAS detector","resumen":"A search is reported for a neutral Higgs boson in the decay channel H&#8594;Z&#947;,Z&#8594;l+l&#8722;(l=e,µ), using 4.5 fb&#8722;1 of pp collisions at s&#8730; = 7 TeV and 20.3 fb&#8722;1 of pp collisions at s&#8730;   = 8 TeV, recorded by the ATLAS detector at the CERN Large Hadron   Collider. The observed distribution of the invariant mass of the three   final-state particles, mll&#947;,   is consistent with the Standard Model hypothesis in the investigated   mass range of 120?150 GeV. For a Higgs boson with a mass of 125.5 GeV,   the observed upper limit at the 95% confidence level is 11 times the   Standard Model expectation. Upper limits are set on the cross section   times branching ratio of a neutral Higgs boson with mass in the range   120?150 GeV between 0.13 and 0.5 pb for s&#8730; = 8 TeV at 95% confidence level.","palabras_clave":"ATLAS|HIGH|ENERGY|PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39553,"idioma_id":4,"titulo":"Search for supersymmetry at s&#8730;=8 TeV in final states with jets and two same-sign leptons or three leptons with the ATLAS detector","resumen":"A search for strongly produced supersymmetric particles is conducted using signatures involving multiple energetic jets and either two isolated leptons (e or &#956;) with the same electric charge, or at least three isolated leptons. The search also utilises jets originating from b-quarks, missing transverse momentum and other observables to extend its sensitivity. The analysis uses a data sample corresponding to a total integrated luminosity of 20.3 fb(&#8722;1) of = 8 TeV proton-proton collisions recorded with the ATLAS detector at the Large Hadron Collider in 2012. No deviation from the Standard Model expectation is observed. New or significantly improved exclusion limits are set on a wide variety of supersymmetric models in which the lightest squark can be of the first, second or third generations, and in which R-parity can be conserved or violated.","palabras_clave":"ATLAS|HIGH|ENERGY|PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39554,"idioma_id":5,"titulo":"ALCANCES Y LIMITACIONES PARA LA IDENTIFICACIÓN ARQUEOLÓGICA DE  GRÁNULOS DE ALMIDÓN DE RAZAS NATIVAS DE ZEA MAYS (POACEAE) DEL  NOROESTE ARGENTINO","resumen":"Se caracterizaron y analizaron microscópicamente los gránulos de almidón de ocho razas nativas de Zea mays del noroeste de Argentina (pisingallo, cristalino colorado, perlita, calchaquí, complejo tropical, dentado amarillo-colorado, chullpi y capia). Se generó una base de datos de referencia con caracteres morfológicos y métricos de los gránulos de almidón de las razas locales para dar cuenta de la diversidad a nivel intra e inter-racial. El objetivo de este trabajo es reconocer elementos referenciales para lograr mejores y más confiables identificaciones de los gránulos de almidón de maíz en muestras arqueológicas. Para este fin se utilizaron herramientas estadísticas descriptivas y se realizaron análisis multivariados; se aplicó un tratamiento estadístico para los datos para estimar la clasificación de los gránulos de almidón por razas. Los resultados mostraron una alta variabilidad para cada raza y una gran   superposición entre las razas. Ninguna de las razas de maíz presentó características distintivas que permitan una discriminación en grupos.","palabras_clave":"Almidón|Arqueobotánica|Razas nativas|Zea mays"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39555,"idioma_id":4,"titulo":"CHEMOMETRIC APPROACH TO VISUALIZE AND EASILY INTERPRET DATA FROM SEQUENTIAL EXTRACTION  PROCEDURES APPLIED TO SEDIMENT SAMPLES.","resumen":"The aim of this study was to assess metal mobility\/availability in coastal surface (oxic) sediment samples from the Bahía Blanca estuary. Particularly, two sequential extraction procedures able to discriminate metals associated to amorphous Fe and Mn oxides and those associated with crystalline oxides of Fe were applied. Sequential procedures differ in the number of steps, type of reagents used, and in the order in which metals associated to organic matter are extracted. The studied metals were Cd, Cr, Cu,Pb, Ni and Zn because of their hazardous potential and relative abundance in the estuary. Tucker4 model with three factors describes appropriately the data sets (explained variance of 64.05%). This model made it possible to visualize and explain the information underlying in the data set. From the multivariate analysis, it was possible to evaluate the metal behaviour and their availability. In this way, Cd and Zn are associated to the more available fractions whereas Ni, Cr, Cu and Pb are mainly associated to the unavailable fractions. On the other hand, Zn and Cu are associated to organic matter fraction. Despite the fact that the two fractionation schemes are quite different, the results obtained with both schemes are comparable.","palabras_clave":"Four-way Tucker model|Metal fractionation|Oxide phases|Sequential extraction procedures"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39556,"idioma_id":4,"titulo":"ANALYSIS  OF  METALS  AND  PHOSPHORUS  IN  BIODIESEL  B100  FROM  DIFFERENT FEEDSTOCK  USING  A  FLOW  BLURRING MULTINEBULIZER  IN  INDUCTIVELY  COUPLED PLASMA-OPTICAL  EMISSION  SPECTROMETRY.","resumen":"A simple and fast method for determining the content of Na, K, Ca, Mg, P, and 20 heavy metals in biodiesel samples with inductively coupled plasma optical emission spectrometry (ICP OES) using a two-nozzleFlow Blurring1 multinebulizer prototype and on-line internal standard calibration, are proposed. The biodiesel samples were produced from different feedstock such as sunflower, corn, soybean and grapeseed oils, via a base catalyst transesterification. The analysis was carried out without any sample pretreatment. The standards and samples were introduced through one of the multinebulizer nozzles,while the aqueous solution containing yttrium as an internal standard was introduced through the second nozzle. Thus, the spectral interferences were compensated and the formation of carbon deposits on the ICP torch was prevented. The determination coefficients (R2) were greater than 0.99 for the studied analytes, in the range 0.21?14.75 mg kg1. Short-term and long-term precisions were estimated as relative standard deviation. These were acceptable, their values being lower than 10%. The LOQ for majorcomponents such as Ca, K, Mg, Na, and P, were within a range between 4.9 ng g1 for Mg (279.553 nm) and 531.1 ng g1 for Na (588.995 nm), and for the other 20 minor components they were within a rangebetween 1.1 ng g1 for Ba (455.403 nm) and 2913.9 ng g1 for Pb (220.353 nm). Recovery values rangedbetween 95% and 106%.","palabras_clave":"Multinebulizer|ICP OES|Inorganic elemental analysis|Biodiesel"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39557,"idioma_id":4,"titulo":"APPLICATION OF A FULLY INTEGRATED PHOTODEGRADATION-DETECTION   FLOW-BATCH ANALYSIS SYSTEM WITH AN ON-LINE PRECONCENTRATION STEP FOR THE DETERMINATION OF METSULFURON METHYL IN WATER SAMPLES.","resumen":"This workpresentsthedevelopmentofafullyautomated flow-batchanalysis(FBA)system as a new approachforon linepreconcentration,photodegradationand fluorescence detectioninalab-constructedmixingchamberthatwasdesignedtoperformtheseprocesseswithoutsampledispersion.Thesystempositionsthemixingchamberintothedetectionsystemandvariestheinstrumentalparametersaccordingtotherequiredphotodegradationconditions.ThedevelopedFBAsystemissimpleand easilycoupledwithanysamplepretreatmentwithoutalteringtheconfiguration.ThisFBAsystemwasimplementedtophotodegradeanddeterminethe fluorescenceofthedegradationproductsofmetsulfuronmethyl(MSM),anaturallynon-fluorescentherbicideofthesulfonylurea'sfamily.Anon-linesolidphaseextraction(SPE)andcleanupprocedureusingaC18minicolumnwascoupledtothephotodegradation-detectionmixingchamber(PDMC)thatwaslocatedinthespectrofluorometer.Anenrichmentfactorof27wasachieved.Photodegradationconditionshavebeenoptimizedbyconsideringtheinfluenceoftheelutionsolventonboththeformationofthephotoproductandonthe fluorescencesignal.Underoptimalconditions,thecalibrationfortheMSMdeterminationwaslinearovertherangeof1.00?7.20 mg L1. Thelimitofdetection(LOD)was0.28 mg L1; therelativestandarddeviationwas2.0%andthesamplethroughputfortheentireprocesswas3h1. TheproposedmethodwasappliedtorealwatersamplesfromtheBahíaBlanca'sagriculturalregion(BahíaBlanca,BuenosAires,Argentina).Thismethodobtainedsatisfactoryrecoverieswitharangeof94.7?109.8%.","palabras_clave":"On-line solidphaseextraction|Flow-batchanalysis|Photoinduceddegradation|Fluorescence Metsulfuron methyl"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39558,"idioma_id":4,"titulo":"Fly emergence from manure of Japanese quail fed thymol or isoeugenol supplemented diets","resumen":"Many  problems in poultry production are caused by a combination of interrelated  factors such as management, stress, nutrition and exposure to pathogens. Saprophagous  flies that develop in poultry manure are a potential route of pathogen transmission.  Besides their nuisance, defecation and regurgitation of flies soils equipment  and structures and can reduce light levels of lighting fixtures. These effects  clearly affect management and may contribute to reductions in poultry egg  production, health and welfare. Many essential oils or their main components  have bioactive effects such as natural repellents and insecticides,  antioxidants, anticholesterolemics, and antimicrobials. This study evaluated if  supplementing quail feed with thymol or isoeugenol as functional food could  alter the production of flies from manure. Dropping samples deposited by quail  fed with a supplementation of 2000 mg thymol or isoeugenol per kg of feed or no  supplement (control) were collected. Each sample was incubated inside an  emergence cage that was inspected daily to collect emerging adult flies. Fewer  flies emerged from droppings of quail fed a thymol supplemented diet (P = 0.01) and tended to a lower  emergence from droppings of isoeugenol fed quail (P = 0.09). The number of positive containers for Musca domestica was smaller from quail droppings  of thymol (P = 0.02) or isoeugenol (P = 0.01) supplemented feed than from  their control counterparts, suggesting an oviposition repellent effect.  Supplementing quail feed with thymol or isoeugenol has an overall moderate  effect against flies, reducing M.  domestica emergence.","palabras_clave":"dietary supplementation|essential oil|fly control"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39559,"idioma_id":4,"titulo":"Noise-sustained synchronization in a FitzHugh-Nagumo ring with electrical phase-repulsive coupling","resumen":"We study the dynamical response under local noise of an excitable ring of FitzHugh-Nagumo units coupled through nearest-neighbor phase-repulsive electric synapses. The system is externally, adiabatically driven by a weak subthreshold periodic signal and independent Gaussian white noises. By varying the coupling strength and the noise intensity, two routes to noise-sustained synchronization are numerically observed and elucidated in terms of the system?s non-equilibrium potential. In particular, the threshold  noise intensity for synchronization is theoretically predicted and numerically confirmed.","palabras_clave":"FitzHugh-Nagumo|synchronization|phase-repulsive coupling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39560,"idioma_id":4,"titulo":"ENCRUSTATION IN NAUTILIDS: A CASE STUDY IN THE CRETACEOUS SPECIES CYMATOCERAS PERSTRIATUM, NEUQUÉN BASIN,  ARGENTINA","resumen":"In this work the  encrusting fauna of abundant material of the nautilid Cymatoceras perstriatum (Steuer) is statistically and taxonomically  analyzed in order to infer paleoecological and taphonomic features of the  fossil organism. The available material of C.  perstriatum is composed mainly of phragmocone fragments, with rare cases in  which the body chamber was preserved. Nine encrusting taxa (cementing bivalves,  serpulids, sabellids, cyclostome bryozoans and agglutinated foraminifers) were  found in C. perstriatum; they are  strongly dominated by oysters, and evenly distributed across the nautilid  shell. Encrusters are rather abundant, with a mean of 12 encrusters per shell.  Internal encrustation is common, especially inside the body chamber, which  could be extensively encrusted. Orientation of encrusters is very variable.  Intensity of encrustation varies, with some shells heavily colonized while  others remained clean. The encrusting fauna is interpreted as mostly post mortem, originated both during the  necroplanktonic drift and as the shell rested on the sea bottom, &nbsp;given that encrusters are distributed across  the shell in a uniform way, they lack particular orientation, and they are  common in the inside of the body chamber. Few encrusters were trapped between  shell whorls, indicating that less extensive in vivo encrustation took place. Some differences in encrustation  parameters were found among localities, corresponding to minor  paleoenvironmental differences. Variable encrustation intensity suggests  moderate to prolonged time of exposition of the shells, but those collected  from an exceptional concentration in one of the localities (El Salado) were  probably buried shortly after death.","palabras_clave":"Cretaceous|nautilid|encruster|taphonomy|necroplanktonic drift"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39561,"idioma_id":5,"titulo":"Imposex en Voluta musica (Caenogastropoda: Volutidae) en el Noreste de la Península de Araya, Venezuela","resumen":"Voluta musica is a dioecious marine gastropod endemic of the South Caribbean. Tributyltin (TBT)and copper (Cu) are potential inducers of imposex, an endocrine disorder by which females develop a penisand\/or vas deferens. The goal of this work was to determine the imposex incidence in V. musica populationsfrom Northeastern Península de Araya. For this, we selected three sites (Isla Caribe, Isla Lobos and Bajo Cuspe)and made monthly samplings of 15 snails in each site, during one year, and determined: (1) sizes; (2) sex andimposex incidence and (3) the Relative Penis Length Index (RPLI). We also performed histological analysisof the gonads, and measured TBT and Cu concentrations in sediments from the studied localities. Our resultsshowed that the total number of sampled females affected by imposex was 24.5% at Isla Caribe, 12% at IslaLobos, and none at Bajo Cuspe. In sediments, Cu was detected mostly in Isla Lobos. The female gonads withimposex did not show any development of male cells in any of the sampled sites. The higher percentage offemales with imposex matched with the higher boat traffic locality, and higher TBT level (Isla Caribe). Noesterilization was evident in this work, nevertheless, the presence of TBT and Cu in the sediments and femaleswith imposex were considered as a potential threat to V. musica populations in this region. In Venezuela there isno control over this particular issue, possibly because of the lack of information and research in this topic, butcertainly, this information will be useful in biodiversity conservation policies","palabras_clave":"IMPOSEX|VOLUTIDAE|TBT|HEAVY METALS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39562,"idioma_id":5,"titulo":"Áreas de entierro en cazadores-recolectores del Noroeste de Patagonia: sitio Hermanos Lazcano (Chos Malal, Neuquén)","resumen":"En este trabajo se presenta la caracterización bioarqueológica del sitio Hermanos Lazcano y se discuten los resultados en relación con el registro bioarqueológico regional. Se estableció el estado de preservación ósea, la composición sexual y etaria de la muestra, la cronología y la presencia de modificaciones intencionales del cráneo. Se trata de un entierro múltiple de 3780 años AP, compuesto por un número mínimo de 4 subadultos y 8 adultos de ambos sexos. El conjunto óseo presenta elevado índice de fragmentación y pobre estado de conservación. Se determinó la presencia de modificación del cráneo circular y pseudocircular. El material cultural comprende bases de molino, cuentas y un colgante de valva, una esfera lítica y litos trapezoidales. Estos resultados indican que el surgimiento de áreas de entierro con alta concentración de individuos se habría producido en los grupos cazadores-recolectores del norte neuquino en momentos más tempranos que en otras regiones patagónicas.","palabras_clave":"BIOARQUEOLOGÍA|HOLOCENO TARDÍO INICIAL|PRÁCTICAS MORTUORIAS|ENTIERROS MÚLTIPLES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39563,"idioma_id":4,"titulo":"Effect of drying operating conditions on canola oil tocopherol content","resumen":"The aim of this work was to evaluate two operating parameters of seed drying  (temperature and initial moisture content) on the tocopherol content of canola oil. The raw material was characterized by moisture, oil, protein, crude fiber and ash content. Seeds at 13.6% and 22.7% moisture content (dry basis, db) were dried at temperatures in the range of 35?100 °C to a safe storage moisture of 7% db. Oil was extracted from each treated sample. The oil extracted from the samples dried at the extreme temperatures was analyzed by means of the acidity value, peroxide index and fatty acid composition, finding no significant differences among treatments or among untreated and treated samples.  Tocopherol contents in the oils obtained for all the assayed temperatures were determined. Differences were found for the samples with 22.7% (db) initial moisture content. Except at 35 °C, temperature affected negatively the oil tocopherol content. However, when 13.6% (db) moisture seeds were processed, no significant differences were observed in the amount of this minor oil component among assays.","palabras_clave":"CANOLA|TOCOPHEROL|ACIDITY VALUE|PEROXIDE INDEX|FATTY ACID COMPOSITION|DRYING OPERATING CONDITIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39564,"idioma_id":4,"titulo":"Kelp Gulls (Larus dominicanus) killed and injured by discarded monofilament lines at a marine recreational fishery in northern Patagonia","resumen":"Among marine debris, monofilament fishing lines often result in negative impacts on marine organisms. We characterized marine debris and incidence of lost and discarded monofilament lines along beaches used by recreational fishers, and report the impact of lines on Kelp Gulls (Larus dominicanus) at the Bahía San Blas protected area, site of one of the main shore-based recreational fisheries of the southwestern Atlantic. Over 55% of the marine debris recorded originated from recreational fishing activities. Balls of tangled monofilament lines were found at a rate of 40.5 items per km. A total of 27 adult Kelp Gulls were found entangled with monofilament. All individuals were tangled to vegetation within colony boundaries. Four of the gulls had a monofilament line protruding from the bill, showing that they may be also killed when trying to obtain bait. Our results indicate that lost or discarded monofilament lines in the Bahía San Blas recreational fishing area result in undesired impacts on coastal wildlife.","palabras_clave":"MONOFILAMENT FISHING LINES|MARINE DEBRIS|KELP GULL|WILDLIFE MORTALITY|RECREATIONAL FISHERIES|BAHÍA SAN BLAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39565,"idioma_id":4,"titulo":"High velocity blue-shifted FeII absorption in the dwarf star-forming galaxy PHL293B: Evidence for a wind driven supershell?","resumen":"X-shooter and ISIS WHT spectra of the starforming galaxy PHL 293B also known as A2228-00 and SDSS J223036.79-000636.9 are presented in this paper.We nd broad (FWHM = 1000km\/s) and very broad (FWZI = 4000km\/s) com- ponents in the Balmer lines, narrow absorption components in the Balmer series blueshifted by 800km\/s, previously undetected FeII multiplet (42) absorptions also blueshifted by 800km\/s, IR CaII triplet stellar absorptions consistent with [Fe\/H] < -2:0 and no broad components or blushifted absorptions in the HeI lines. Based on historical records, we found no optical variability at the 5  level of 0.02 mag between 2005 and 2013 and no optical variability at the level of 0.1mag for the past 24 years. The lack of variability rules out transient phenomena like luminous blue variables or SN IIn as the origin of the blue shifted absorptions of HI and FeII. The evidence points to either a young and dense expanding supershell or a stationary cooling wind,in both cases driven by the young cluster wind.","palabras_clave":"galaxies|abundances|dwarfs|emission lines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39566,"idioma_id":4,"titulo":"Fault-Related Carbonate Breccia Dykes in the La Chilca Area, Eastern Precordillera, San Juan, Argentina","resumen":"                            In this paper attention is focused upon dykes  of carbonate fault breccia from the Cerro La Chilca area, Eastern Precordillera,  central-western Argentina, which provide some clues on the probable mechanism  of both fault movement and dyke injection.           &nbsp;&nbsp;&nbsp;&nbsp; Breccia  dykes are seen intruding Upper Carboniferous sedimentary rocks, as well as in  the Triassic La Flecha Trachyte Formation. The timing of breccia dyke emplacement is constrained between  the uppermost Triassic and the Early Miocene. The study presented  here supports a tectonic-hydrothermal origin for these breccia dykes;  fragmentation and subsequent hydraulic injection of fluidized breccia are the more important processes in the  entire breccia dykes development. Brecciation can be triggered by seismic  activity which acted as a catalyst. The escape of fluidized material must be  attributed to high hydrostatic pressure establishing the direction of least  pressure.          &nbsp;&nbsp;&nbsp;&nbsp; Previous  studies have shown that cross-strike structures have had an important role in  the evolution of this Andean segment since at least Triassic times. These  structures represent pre-existing crustal fabrics that could have controlled  the emplacement of the dykes. The dykes, which are composed mostly of carbonate  fault breccia, were evidently injected upward along WNW fractures.            ","palabras_clave":"BRECCIA DYKES|FLUIDIZATION|CROSS-STRIKE STRUCTURES|ARGENTINE PRECORDILLERA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39567,"idioma_id":4,"titulo":"Increasing Doxycycline Hyclate Photostability by Complexation with b-Cyclodextrin","resumen":"Doxycycline hyclate (DOX) is a highly photosensitive drug, that limits the stability of the corresponding dosage forms. A freeze-drying method was applied to obtain the complex with &#946;-cyclodextrin in the solid state. The photoprotection produced by the complexation was evaluated by means of an antimicrobial assay. Overall, the present results suggest that the formulation of  DOX complexes with &#946;CD constitutes an interesting approach for the preparation of pharmaceutical forms of DOX with enhanced stability properties.","palabras_clave":"b-cyclodextrin|doxycycline hyclate|microbiological assay|molecular modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39568,"idioma_id":4,"titulo":"Development of a Receptor Model for Efficient in silico Screening of HIV-1 Integrase Inhibitors","resumen":"Integrase (IN) is a key viral enzyme for the replication of the type-1 human immunodeficiency virus (HIV-1), and as such constitutes a relevant therapeutic target for the development of anti-HIV agents. However, the lack of crystallographic data of HIV IN complexed with the corresponding  viral DNA has historically hindered the application of modern structure-based drug design techniques to the discovery of new potent IN inhibitors (INIs). Consequently, the development and validation of reliable HIV IN structural models that may be useful for the screening of large databases of chemical compounds is of particular interest. In this study, four HIV-1 IN homology models were evaluated respect to their capability to  predict the inhibition potency of a training set comprising 36 previously reported INIs with IC50 values in the low nanomolar to the high micromolar range. Also, 9 inactive structurally related compounds were included in this training set. In addition, a crystallographic structure of the IN-DNA complex corresponding to the prototype foamy virus (PFV) was also evaluated as structural model for the screening of inhibitors. The applicability of high throughput screening techniques, such as blind and ligand-guided exhaustive rigid docking was assessed. The receptor models were also refined by molecular dynamics and clustering techniques to assess protein sidechain flexibility and solvent effect on inhibitor binding.  Among the studied models, we conclude that the one derived from the X-ray structure of the PFV integrase exhibited the best performance to rank the potencies of the compounds in the training set, with the predictive power being further improved by explicitly modeling five water molecules within the catalytic side of IN. Also, accounting for protein sidechain  flexibility enhanced the prediction of inhibition potencies among the studied compounds. Finally, an interaction fingerprint pattern was established for the fast identification of potent IN inhibitors. In conclusion, we report an exhaustively validated receptor model if IN that is useful for the efficient screening of large chemical compounds databases in the search of potent HIV-1 IN inhibitors.","palabras_clave":"Integrase inhibitors|anti-HIV agents|Molecular docking|Molecular dynamics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39569,"idioma_id":4,"titulo":"Advanced Oxidation Processes for Wastewater Treatment in the Pulp and Paper Industry: A Review","resumen":"The effluents of some pulp and paper processes are potentially pollutant, because of their large volume and their refractory nature. Biological processes generally are not capable to remove these compounds. Advanced Oxidation Processes (AOP)  are  characterized  by  the  capability  of  exploiting  the  high  reactivity  of  HO?  radicals. AOP can produce a total mineralization, transforming recalcitrant compounds into inorganic substances (CO2 and H2O2), or partial mineralization, transforming them into more biodegradable substances. The high reactivity and low selectivity of these radicals are useful attributes that that make these processes in promising technologies. Due to the differences between pulping processes, the effluents from the various processes and operations of such industries also differ from each other, so that some oxidative processes should be combined to improve the removal efficiency. For the effective oxidation of refractory organic compounds, hydroxyl radicals should be generated continuously in situ due to its chemical instability. Generation of HO? is commonly accelerated by combining oxidizing agents. Among these treatments, UV radiation plus hydrogen peroxide (UV\/H2O2), Fenton's reagent (H2O2\/Fe+2), photo-Fenton UV\/H2O2\/Fe+2), and ozone in different combinations (O3\/UV; O3\/H2O2) are considered to be effective for the oxidation of effluents from pulp and paper industries.","palabras_clave":"ADVANCED OXIDATION PROCESSES|COD REMOVAL|PULPING EFFLUENT|RECALCITRANT COMPOUNDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39570,"idioma_id":4,"titulo":"Impact of volcanic ash deposition on foliar productivity and insect herbivory in northern patagonia deciduous forests","resumen":"Abstract. Volcanism has been a major force shaping the dynamics of Andean landscapes during the Holocene. Yet we still know little about the consequences of modern volcanic events on forest functioning. Ash fall may elicit multiple direct and indirect effects on key ecosystem attributes, with disturbance severity likely varying with distance to the crater. We examined the impact of ash deposition on foliage productivity and insect herbivory after the 2011 eruption of the Volcán Puyehue-Cordón Caulle system, in Nothofagus pumilio forests of northern Patagonia, Argentina. Tree leaf litterfall, a surrogate for annual foliar production, was measured before and after the event in wet and dry forest sites, which were located 22 km and 80 km east from the crater and were affected by mass deposition of coarse- and fine-grained tephra, respectively. Leaf damage by insects was monitored over a 10-year span (2004?2013) including the volcanic event. Foliar productivity in 2012 dropped by 60% in the wet forest, but did not change in the dry forest. Leaf area damaged by insects decreased abruptly in 2012, with post-eruption herbivory levels falling outside the range of annual variation recorded before the event. The impact was most severe in the dry forest that normally supports the highest endemic herbivory. In contrast, leaf damage remained high in another dry forest located 98 km southeast from the volcano and little affected by ashfall. Major shifts in foliar production and insect herbivory persisted for two years after the event. These results show a widespread disruption of canopy?herbivore interactions in areas heavily affected by tephra. Remarkably, volcanic ash acted as a broad-spectrum insecticide on canopy herbivores. In the short-term, ashfall constrained the energy flow through the forest canopy and the arthropod consumer community, and thus temporarily overwhelmed previously existing differences in productivity and herbivory between wet and dry forest habitats.","palabras_clave":"Canopy insects|disturbance|herbivory|long-term study|Nothofagus pumilio|productivity|volcanism"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39571,"idioma_id":4,"titulo":"Special section - Ecological responses of arthropods to volcanism","resumen":"Editorial introduction to a special section in Ecología Austral.","palabras_clave":"arthopods|Patagonia|Puyehue-Cordon Caulle|Volcanism"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39572,"idioma_id":4,"titulo":"Atlas-B: Development and Testing of a Brazilian Deep-Ocean Moored Buoy for Climate Research","resumen":"The PIRATA-SWE (Prediction and Research Moored Array in the Tropical Atlantic-Southwest Extension) was conceived in the early 2000s to gather observations necessary to improve the understanding of the variability of ocean-atmosphere interactions in the SACZ (South Atlantic Convergence Zone), which are believed to influence South American climate. To properly monitor the SACZ, the preliminary design for the PIRATA-SWE array considered the mooring of four buoys, with the southernmost one in the sub-tropics. In 2005, three buoys were deployed in the tropical region. Four years later, in 2009, efforts were started to assemble and deploy a Brazilian prototype of the TAO\/PIRATA Atlas (autonomous temperature line acquisition system) buoy?the Atlas-B. Finally, in April 2013 the first Atlas-B, nicknamed ?Guariroba?, was moored for a testing period at 28.5° S, 44° W, which is the site originally planned for the fourth PIRATA-SWE buoy. In early November 2013, after being detected adrift, the buoy with the upper 700 m part of the mooring line was rescued in an emergency operation. In June 2014, the bottom part was successfully recovered. A new deployment is planned for late 2014. This paper describes part of the learning process of adapting and building the Atlas-B buoy and presents a brief discussion of the data collected during the pilot deployment.&nbsp;","palabras_clave":"Atlas-B Buoy|PIRATA|Southwest Atlantic|hurricane Catarina|SACZ"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39573,"idioma_id":4,"titulo":"A peculiar association: the skin and the subcutaneus diverticula of the Southern Screamer (Chauna torquata, Anseriformes)","resumen":"The aim of this work is to describe for the first time the skin and the subcutaneous diverticula at histological level (by light microscopy) of the Southern Screamer Chauna torquata. We found that the main distinguishing features of the skin were the presence of deep and branched epidermal invaginations whereas in the dermis abundant elastic fibers were found. These skin features could provide a great stretchability to the skin which, in turn, are related to the change of volume that may experience the subcutaneous diverticula. Since screamers are flying birds that soar to great heights, the presence of subcutaneous diverticula together with another anatomical features (like a great skeletal pneumaticity) could favor a body mass reduction and an optimization in its mode of locomotion.","palabras_clave":"Pneumaticity|Epidermis|Dermis|Air sacs|Aves|Anhimidae"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39574,"idioma_id":4,"titulo":"Stress concentration around perforations produced by corrosion in steel storage tanks","resumen":"This  paper presents numerical results of stress concentration factors for  plates perforated by corrosion. Evidence from 25 plates with  corrosion perforation considered show that typical shapes may be  characterized as a deviation from an ellipse or from a circle. In  order to model typical perforations created by this type of  corrosion, holes with non-circular boundaries have been considered in  the form of cosine shape and variations from it. Two load cases are  investigated: uniaxial and shear stress fields in an elastic plane  stress problem. The influence of the amplitude of deviation with  respect to an ellipse or circle and the local curvature of the  internal boundary of the hole are studied. A simplified model of an  equivalent ellipse originally proposed by Nishida is shown to provide  good estimates for stress concentration factors for a range of shapes  induced by corrosion.","palabras_clave":"Finite element analysis|Oil tanks|Corrosion|Stress concentration factors"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39575,"idioma_id":4,"titulo":"Methods for estimating the velocities of the Brazil Current in the Pre-Salt reservoir area off Southeast Brazil (23°S-26°S)","resumen":"The Brazil Current (BC) is likely the least observed and investigated subtropical western boundary current in the world. This study proposes a simple and systematic methodology to estimate quasi-synoptic cross-sectional speeds of the BC within the Santos Basin (23°S-26°S) based on the dynamic method using several combinations of data: Conductivity-Temperature-Depth (CTD), temperature profiles, CTD and vessel-mountedAcoustic Doppler Current Profiler (VMADCP), and temperature profiles and VMADCP.All of the geostrophic estimates agree well with lowered Acoustic Doppler Current Profiler(LADCP) velocity observations and yield volume transports of 5.45 ±1.03 Sv and 2.40±0.80 Sv for the BC and the IntermediateWestern Boundary Current (IWBC), respectively. The LADCP data revealed that the BC flows southwestward and is &#8764;100 km wide, 500 m deep, and has a volume transport of approximately -5.75 ±1.53 Sv and a maximum speed of 0.59 m s&#8722;1. Underneath the BC, the IWBC flows northeastward and has a vertical extent of approximately 1300 m, a width of &#8764;60 km, a maximum velocity of &#8764;0.22 m s&#8722;1 and a volume transport of 4.11 ± 2.01 Sv. Our analysis indicates that in the absence of the observed velocities, the isopycnal (s0) of 26.82 kg m&#8722;3 (&#8764;500 dbar) is an adequate level of no motion for use in geostrophic calculations. Additionally, a simple linear relationship between the temperature and the specific volume anomaly can be used for a reliable first estimate of the BC-IWBC System in temperature-only transects.","palabras_clave":"Brazil Current|Intermediate Western Boundary Current|Santos Basin circulation|geostrophic estimates"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39576,"idioma_id":5,"titulo":"Relación magnitud-frecuencia de sismos para  la ciudad de Mendoza, Argentina","resumen":"          El presente artículo  se centra en la determinación de las relaciones Magnitud-Frecuencia para sismos  de magnitudes mayores de tres ocurridos en el sistema de fuentes potenciales  sísmicas ubicadas en la zona del Gran Mendoza, la cual se emplaza en una región  geográfica considerada, según los reglamentos sismorresistentes de la nación,  como de máxima peligrosidad sísmica de la República   Argentina. La probabilidad de ocurrencia se determina para  eventos de una magnitud dada. Resulta conveniente actualizar estas relaciones y  probabilidades, a la luz de la gran cantidad de eventos registrados&nbsp; en los últimos 40 años. La actividad sísmica  de la región ha sido diferenciada por la profundidad del foco sísmico. Las  fuentes de información, para la elaboración del trabajo, contemplan la  sismicidad histórica e instrumental de la zona conjuntamente con las  características sismotectónicas regionales. Las leyes Magnitud-Frecuencia se  representan para sismos con profundidades no mayores a 35 kilómetros.  También se presentan las probabilidades de ocurrencia para terremotos de  magnitud superior a un umbral preestablecido y para distintos períodos de  tiempo.  ","palabras_clave":"MAGNITUD-FRECUENCIA|PROBABILIDAD DE OCURRENCIA|SISMICIDAD LOCAL|PELIGRO SISMICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39577,"idioma_id":4,"titulo":"Reactivity at the Ln2NiO4+d \/ electrolyte interface (Ln= La , Nd) studied by Electrochemical Impedance Spectroscopy and Transmission Electron Microscopy","resumen":"Chemical reactivity between Ln2NiO4+&#948; (Ln: La, Nd) electrodes and Y0.08Zr0.92O1.96 (YSZ) and Ce0.9Gd0.1O1.95 (CGO) electrolytes was analyzed by Electrochemical Impedance Spectroscopy (EIS) and Focused Ion Beam-Transmission Electron Microscopy (FIB-TEM) techniques. Ln 2NiO4+&#948; electrodes were deposited onto CGO and YSZ electrolytes by aerography and treated at 900 °C during 1 h in order to promote electrode adhesion. EIS spectra were collected between 500 and 800 °C in dry air. The Polarization Resistances (PR) values for La 2NiO4\/CGO\/La2NiO4 cell are higher than those of La2NiO4\/YSZ\/La2NiO4. The PR for both cells and its evolution in time suggest that chemical reactivity is developed at 900 °C during the adhesion treatment and at T higher than 650 °C during the EIS measurements. The PR for Nd2NiO 4\/CGO\/Nd2NiO4 and Nd2NiO 4\/YSZ\/Nd2NiO4 are much lower than those of La2NiO4\/CGO\/La2NiO4 and La 2NiO4\/YSZ\/La2NiO4 cells. These values and the slight increase of PR with time for Nd2NiO4 (NNO) electrodes indicate that the strength of chemical reactivity is much lower than that of La2NiO4 (LNO). TEM results confirmed that reactivity between CGO and LNO is much higher than that of YSZ and LNO and also confirm that the strength of reactivity is appreciably lower for NNO as electrode material.","palabras_clave":"Chemical reactivity|Electrochemical Impedance Spectroscopy|Interface| Intermediate temperature-solid oxide fuel cell"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39578,"idioma_id":4,"titulo":"PhysicoChemical Studies of Complex Silver-Magnetite Nano Heterodimers with Controlled Morphology","resumen":"The influence of synthesis conditions on self-assembly capability and  morphology of obtained Ag?Fe3O4 nano-heterostructures is  discussed in this work. Samples were synthesized in two steps, first were  synthesized silver nanoparticles, used as seeds for the growth of iron oxide  nanoparticles in a second step. The silver nanoparticles size was tuned changing  the oleylamine (OAm) and oleic acid (OA) ratio, which us to study the influence  of chemical agents and seed size on the final magnetic nanoparticles  morphology. The mechanism during the formation of these heterostructures has  been discussed by several authors, however it still remains as an open issue.  In this paper we extend the discussion and advance on the understanding of  synthesis condition, related to silver sizes, chemical agents and physical  properties on the obtained nanoparticles. In our Ag-Fe3O4  system, two types of heterostructures were obtained; dimer, flower or their  combination. We have found that the final shape depends on silver seed size, as  well the polarity of the chemical agents used during the synthesis. We made an  exhaustive study of the relationship between magnetic properties and structural  features. The morphology and size  distributions of the heterostructures have been analyzed by transmission  electron microscopy (TEM).   ","palabras_clave":"Dimer Nano-Heterostructure|Flower Nano-Heterostructure|Dipolar Interaction|self-assembly"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39579,"idioma_id":4,"titulo":"Studies in Diatrypaceae: new taxon and investigation in  ligninolytic enzyme production.","resumen":"In this study the extracellular production of ligninolytic enzymes by xylariaceous and diatrypaceous species from Argentina was investigated. Among them, a new species (Eutypa microasca) was evaluated. Its morphological characteristics (e.g.: very small asci), along with the molecular analyses, support the hypothesis of the new taxon. Ligninolytic enzyme production by several saprophytic and endophytic strains belonging to the genera Xylaria, Eutypella, Eutypa and Peroneutypa was assessed on solid medium supplemented with different dyes (Poly R-478, Azure B and Malachite Green) and under submerged fermentation in copper amended malt extract\/glucose medium. All the strains produced laccase in liquid cultures, and seven out of nine also produced Mn-peroxidase (highest titres detected 113 U\/l). Only 5 of the strains assayed could not decolorize Malachite Green. This is the first report on laccase and Mn-peroxidase production by the members of the Diatrypaceae and contributes to the knowledge on ligninolytic enzyme production in the members of the Xylariaceae, scarcely studied up to date.","palabras_clave":"Diatrypaceae|Eutypa microasca| ligninolytic enzymes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39580,"idioma_id":4,"titulo":"Vibrisseaceous fungi from the southern hemisphere, including Chlorovibrissea chilensis (Helotiales, incertae sedis) sp. nov","resumen":"The discovery of Chlorovibrissea chilensis sp. nov. expands the geographic distribution of Chlorovibrissea from Australasia to include South America. C. chilensis, phylogenetically distinct from other species in the genus, is characterized morphologically by its ascoma with emerald green stalk and pale orange brown head, budding paraphyses and 5-6-septate ascospores. Based on the phylogenetic analysis, the Australasian species Vibrissea albofusca is recombined in Chlorovibrissea, despite it lacking the distinctive green pigmentation of other species in this genus. In addition, the genus Vibrissea in a strict genetic sense is confirmed from the Southern Hemisphere for the first time; Vibrissea truncorum is reported from Chile and V. flavovirens from New Zealand.","palabras_clave":"ASCOMYCOTA|CHILE|NEW ZEALAND|NOTHOFAGUS|PHYLOGENY|VIBRISSEA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39581,"idioma_id":5,"titulo":"INESTABILIDAD DEL DESARROLLO EN ESTRUCTURAS CRANEOFACIALES DE POBLACIONES HUMANAS SUDAMERICANAS","resumen":"Diversos factores genéticos  y ambientales pueden actuar sobre los mecanismos que amortiguan el efecto de perturbaciones aleatorias durante el desarrollo,  resultando en un aumento de la inestabilidad del desarrollo (ID)&nbsp; y de la variación a nivel individual. El  objetivo de este trabajo es analizar el grado y patrón de asimetría fluctuante  (AF) en el cráneo, como una medida de ID, en poblaciones con distinto tipo de  subsistencia. Asimismo, se evalua la existencia de diferencias entre la base, bóveda y esquelto facial. Se relevaron landmarks tridimensionales sagitales y  bilaterales en 109 cráneos de Chubut, San Juan y SO de Pampa. El método de  Superposición Procrustes Generalizado fue usado para extraer los componentes  simétrico y asimétrico de la forma. Los análisis preliminares indicaron que el  error de medición y la asimetría direccional dan cuenta de un porcentaje  reducido de la variación total, mientras la AF explica entre el 10 y 15 %. La  magnitud de AF-estimada como la distancia Procrustes entre las configuraciones  originales y sus imágenes reflejadas- de la bóveda y la región  facial, resultó mayor en San Juan, mientras la base no presentó diferencias  entre las muestras. Los patrones de forma del componente asimétrico indican que  la muestra de Chubut se diferencia en la base y la cara, mientras la de San  Juan en la bóveda. En resumen, los resultados obtenidos  sugieren variación modular en la ID del cráneo y diferencias entre grupos cazadores-recolectores y agricultores. ","palabras_clave":"asimetría fluctuante|modularidad|cazadores-recolectores|agricultores"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39582,"idioma_id":5,"titulo":"ASIMETRÍA DIRECCIONAL DEL POSTCRÁNEO EN POBLACIONES PREHISPÁNICAS DEL SUR DE SUDAMÉRICA","resumen":"El objetivo de este trabajo es estudiar los patrones de asimetría direccional en el tamaño de los huesos largos en poblaciones aborígenes de cazadores-recolectores y agricultores del sur de Sudamérica. Se midieron variables del postcráneo de 272 individuos adultos de ambos sexos correspondientes a cinco muestras de las regiones pampeana, patagónica y Noroeste de Argentina y de la Costa y Valle de Azapa, en el Norte de Chile. Asimismo, se recolectaron datos de 139 individuos adultos de ambos sexos correspondientes a tres muestras del Norte, Sudeste y Sudoeste de Norteamérica. Los datos obtenidos se analizaron en términos de lateralidad y magnitud, dimorfismo sexual y diferencias por modo de subsistencia. Los resultados muestran diferencias significativas, en la asimetría direccional en el miembro superior, particularmente en el diámetro de la diáfisis del húmero. A su vez, estos resultados sugieren que el modo de subsistencia, al menos en las categorías consideradas en este trabajo, no es una variable ambiental adecuada para explicar los patrones de asimetría direccional entre las poblaciones estudiadas.","palabras_clave":"Lateralidad|Plasticidad|Patrones de actividad|Dimorfismo sexual"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39583,"idioma_id":4,"titulo":"Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?","resumen":"Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between anti-natriuretic and natriuretic factors. Renal dopamine plays a central role on this interactive network. The natriuretic hormones such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, receptor sensitization) which can be regulated by the atrial natriuretic peptide. At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the over inhibition of Na+, K+-ATPase activity. In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and\/or atrial natriuretic peptide or as a result of impaired interaction between these two natriuretic systems. The aim of this review is to update and comment the most recent evidences demonstrating how the renal dopaminergic system interact with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways.","palabras_clave":"DOPAMINE|KIDNEY|ATRIAL NATRIURETIC PEPTIDE|NATRIURESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39584,"idioma_id":4,"titulo":"Radiation impact assessment of naturally occurring radionuclides and magnetic mineral studies of Bharathapuzha river sediments, South India","resumen":"The natural radioactivity levels and magnetic measurements in sediment samples of Bharathapuzha river for the first time have been determined. Bottom sediments from 33 locations were collected to determine 226Ra, 232Th and 40K using a HPGe detector based on the high-resolution gamma spectrometry system, and magnetic susceptibility by using Bartington MS2 magnetic susceptibility meter. The calculated activity concentrations of 226Ra, 232Th and 40K have been found to vary from 21.21 to 66.03 Bq kg&#8722;1, 33.49 to 93.10 Bq kg&#8722;1 and 232.25 to 899.66 Bq kg&#8722;1, respectively. The results have been compared with worldwide recommended values and also with radioactivity measurements in river sediments of India and other parts of the world. The air-absorbed dose rate, indoor and outdoor annual effective dose rates and radium equivalent activity are calculated with an aim to access the radiation hazards arising due to the use of these materials in the construction of buildings and their mean values obtained are 74.83 nGy h&#8722;1, 367.08 &#956;Sv y&#8722;1, 91.77 &#956;Sv y&#8722;1 and 157.09 Bq kg&#8722;1, respectively. The mass-specific magnetic susceptibility values ranged widely from 35.4 to 2,160.5 × 10&#8722;8 m3 kg&#8722;1 and compared with other rivers in South India. Multivariate statistical analyses were performed to describe the magnetic and radioactivity relevance of the different groups of samples. The data obtained in the present study may be useful for radiological and magnetic mapping of the study area in the future.","palabras_clave":"Natural radioactivity|Hazard indices |Magnetic susceptibility |Fuzzy c-means clustering"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39585,"idioma_id":4,"titulo":"Variation of thermal parameters in two different color morphs of a diurnal poison toad, Melanophryniscus rubriventris (Anura: Bufonidae)","resumen":"WestudythevariationinthermalparametersintwocontrastingpopulationsYungasRedbellyToads  (Melanophryniscus rubriventris) withdifferentdiscretecolorphenotypescomparing field bodytempera-  tures, criticalthermalmaximumandheatingrates.Wefoundsignificant differencesin field body  temperaturesofthedifferentmorphs.Temperatureswerehigherintoadswithahighextentofdorsal  melanization. Novariationwasregisteredinoperativetemperaturesbetweenthestudylocationsatthe  moment ofcaptureandprocessing.Criticalthermalmaximumoftoadswaspositivelyrelatedwiththe  extentofdorsalmelanization.Furthermore,wefoundedsignificant differencesinheatingratesbetween  morphs, whereindividualswithahighextentofdorsalmelanizationshowedgreaterheatingratesthan  toads withlowerdorsalmelanization.Thecolorpattern-thermalparameterrelationshipobservedmay  influence theactivitypatternsandbodysizeofindividuals.Bodytemperatureisamodulatorof  physiologicalandbehavioralfunctionsinamphibians,influencing dailyandseasonalactivity,locomotor  performance, digestionrateandgrowthrate.Itispossiblethatsomegrowthconstraintsmayarisedueto  the relationshipofcolorpattern-metabolismallowingdifferentmorphstoattainsimilarsizesatdifferent  locations insteadofbody-sizecline","palabras_clave":"MELANIZATION|COLORATION|CRITICAL THERMAL MAXIMUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39586,"idioma_id":4,"titulo":"First survey of nematode parasites in introduced American Bullfrogs (Lithobates catesbeianus) in Argentina","resumen":"We provide the first report of nematode parasites from the introduced American Bullfrog (Lithobates catesbeianus) in San Juan Province, Argentina. Sixteen individuals (7 adult females, 6 adult males, and 3 juveniles) of L. catesbeianus were studied.  Thirteen (81.3%) of the frogs harbored two species of nematodes: larvae of Contracaecum sp. (Nematoda, Anisakidae) in their serosal surface of the stomach wall and at the gastroduodenal junction, and the adults of Falcaustra sanjuanensis (Nematoda, Kathlaniidae) in their large intestine. Previous studies of introduced populations of American Bullfrogs in Argentina have focused on population structure, trophic ecology, and their impacts on native amphibian and other vertebrate populations. More studies of their parasites need to be conducted in South America generally, and Argentina specifically, in order to assess the extent to which bullfrogs introduce new parasites or are infected by native parasites and the potential impacts of non native parasites on native frog species.","palabras_clave":"AMERICAN BULLFROG|NEMATODE PARASITES| LITHOBATES CATESBEIANUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39588,"idioma_id":4,"titulo":"Development of an antioxidant phytoextract of Lantana grisebachii with lymphoprotective activity against in vitro arsenic toxicity","resumen":"Phytochemicals have been presumed to possess prophylactic and curative properties in several pathologies, such as arsenic- (As-) induced immunosuppression. Our aim was to discover a lymphoprotective extract from Lantana grisebachii Stuck. (Verbenaceae) (LG). We assessed its bioactivity and chemical composition using cell-based assays. Fractions produced from a hexane extract acutely induced nitrite formation in T-activated cell cultures (P < 0.0001). Water extraction released a fraction lacking nitrite inducing activity in both lymphocyte types. Aqueous LG was found to be safe in proliferated and proliferating cells. The infusion-derived extract presented better antioxidant capacity in proportion to phenolic amount in lymphocytes (infusive LG-1i at 100 µg\/mL), which protected them against in vitro As-induced lymphotoxicity (P < 0.0001). This infusive LG phytoextract contained 10.23 ± 0.43 mg\/g of phenolics, with 58.46% being flavonoids. Among the phenolics, the only predominant compound was 0.723mg of chlorogenic acid per gram of dry plant, in addition to 10 unknown minor compounds. A fatty acid profile was assessed. It contained one-third of saturated fatty acids, one-third of &#969;9, followed by &#969;6 (&#8764;24%) and &#969;3 (&#8764;4%), and scarce &#969;7. Summing up, L. grisebachii was a source of bioactive and lymphoprotective compounds, which could counteract As-toxicity. This supports its phytomedical use and research in order to reduce As-related dysfunctions.","palabras_clave":"LANTANA GRISEBACHII|LYMPHOPROTECTIVE ACTIVITY|ARSENIC TOXICITY|ANTIOXIDANTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39589,"idioma_id":5,"titulo":"Mantenimiento de la integridad cromosómica frente al daño inducido por el veneno de topoisomerasa II Etopósido en células humanas","resumen":"El presente trabajo evaluó la participación de la vía reunión de extremos no homólogos dependiente de la proteína quinasa DNA-PKcs (D-NHEJ) en la reparación y progresión del daño inducido en el ADN por etopósido (ETO) en la fase G2 de las células humanas HeLa. ETO induce rupturas de doble cadena (RDC) en G2 que se convierten en aberraciones cromosómicas estructurales por falta y\/o incorrecta reparación de las mismas en la metafase siguiente al tratamiento. Las células tratadas con ETO presentan rupturas e intercambios de tipo cromatídico. Cuando DNA-PKcs está inhibida químicamente, las células utilizan una vía alternativa que opera como ?backup? de NHEJ, denominada B-NHEJ. La inhibición de DNA-PKcs con NU7026 en combinación con ETO resulta en la duplicación de las aberraciones cromatídicas obtenidas y produce una importante citotoxicidad. El daño cromosómico inducido por ETO en G2 progresa a la fase G1 posmitótica generando micronúcleos (MN) y persistencia de RDC en los MN y núcleos principales de células binucleadas. Este efecto se potencia por la inhibición química de D-NHEJ asociado a una reducción de células binucleadas. En conclusión, en células HeLa, D-NHEJ mantiene la integridad cromosómica y promueve la progresión de células dañadas al siguiente ciclo celular.","palabras_clave":"DNA TOPOISOMERASA II|REUNIÓN DE EXTREMOS NO HOMÓLOGOS|ETOPÓSIDO|REPARACIÓN DE DAÑO CROMOSÓMICO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39590,"idioma_id":4,"titulo":"Identification of differentially expressed genes potentially involved in the tolerance of Lotus tenuis to long-term alkaline stress","resumen":"Soil alkalinity is one of the most serious agricultural problems limiting crop yields. The legume Lotus tenuis   is an important forage acknowledged by its ability to naturally grow in   alkaline soils. To gain insight into the molecular responses that are   activated by alkalinity in L. tenuis plants, subtractive cDNA   libraries were generated from leaves and roots of these plants. Total   RNAs of non-stressed plants (pH 5.8; E.C. 1.2), and plants stressed by   the addition of 10 mM of NaHCO3 (pH 9.0; E.C. 1.9), were used   as source of the driver and the tester samples, respectively. RNA   samples were collected after 14 and 28 days of treatment. A total of 158   unigenes from leaves and 92 unigenes from roots were obtained and   classified into 11 functional categories. Unigenes from these categories   (4 for leaves and 8 for roots), that were related with nutrient   metabolism and oxidative stress relief were selected, and their   differential expression analyzed by qRT-PCR. These genes were found to be differentially expressed in a time dependent manner in L. tenuis   during the alkaline stress application. Data generated from this study   will contribute to the understanding of the general molecular mechanisms   associated to plant tolerance under long-term alkaline stress in   plants.","palabras_clave":"ALKALINE STRESS|SUPPRESIVE SUBSTRACTIVE HYBRIDIZATION|LOTUS TENUIS|STRESS INDUCED TRANSCRIPTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39591,"idioma_id":4,"titulo":"Activity of digestive enzymes in chicken's small intestine and caeca: Effect of dietary protein and carbohydrate content","resumen":"Digestion is a mediating factor between the animals and their environment, one of the variables related to the efficiency in extracting energy from nutrients is rate of hydrolysis. Phylogenetical and functional hypothesis has been proposed linking dietary flexibility and enzyme lability. Species belong to Parvclass Galloanserae, studied until now, did not modulate aminopeptidase-N activity but they did modulate disaccharidases activities. Additionally, peptide hydrolysis has been demonstrated in avian caeca, but not in chickens. Finally, dietary proteins are essential for chicken growth in the first stages of development, but little information is available in chickens beyond 42 days of life. Chickens beyond that age were fed for 15 days either a high protein (DHP 49.72% protein, 11.92% carbohydrates) or a high starch diet (DHS 52.82% carbohydrates, 10.49% protein). Aminopeptidase-N, maltase and sucrase, were assessed in chicken?s small intestines and caeca. Body mass of DHP birds was 37.5%> higher than body mass of DHS birds, at the end of the trial. Aminopeptidase-N and sucrase did not change, but maltase exhibited higher activity in DHS than in DHP birds. The lack of aminopeptidase-N modulation and its relatively high activity in caeca, together with a modulation of maltase, contribute and give apparent support to the functional hypothesis. Surprisingly, a high quantity of protein resulted important for growth in chickens after 42 days of life. Also it is important to notice that a casein diet has been demonstrated as a high digestible meal for chickens, so the last data  may be of interest for poultry industry.","palabras_clave":"Chickens|caeca|dietary carbohydrates|dietary proteins|enzyme digestion|growth pattern|phenotypic flexibility"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39592,"idioma_id":4,"titulo":"Backscattering and absorption coefficients for electrons: Solutions of invariant embedding transport equations using a method of convergence","resumen":"The backscattering coefficient is a magnitude whose measurement is fundamental for the  characterization of materials with techniques that make use of particle beams and particularly when  performing microanalysis. In this work, we report the results of an analytic method to calculate the  backscattering and absorption coefficients of electrons in similar conditions to those of electron  probe microanalysis. Starting on a five level states ladder model in 3D, we deduced a set of  integro-differential coupled equations of the coefficients with a method know as invariant  embedding. By means of a procedure proposed by authors, called method of convergence, two  types of approximate solutions for the set of equations, namely complete and simple solutions, can  be obtained. Although the simple solutions were initially proposed as auxiliary forms to solve  higher rank equations, they turned out to be also useful for the estimation of the aforementioned  coefficients. In previous reports, we have presented results obtained with the complete solutions. In  this paper, we present results obtained with the simple solutions of the coefficients, which exhibit a  good degree of fit with the experimental data. Both the model and the calculation method  presented here can be generalized to other techniques that make use of different sorts of particle  beams. VC 2014 AIP Publishing LLC.","palabras_clave":"Backscattering|Microanalyisis|Invariant|Inmbedding"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39593,"idioma_id":4,"titulo":"Dynamics of entanglement between two harmonic modes in stable and unstable regimes","resumen":"The exact dynamics of the entanglement between two harmonic modes generated by an angular momentum coupling is examined. Such a system arises when considering a particle in a rotating anisotropic harmonic trap or a charged particle in a fixed harmonic potential in a magnetic field, and it exhibits a rich dynamical structure, with stable, unstable, and critical regimes according to the values of the rotational frequency or field and trap parameters. Consequently, it is shown that the entanglement generated from an initially separable Gaussian state  can exhibit quite distinct evolutions, ranging from quasiperiodic behavior in stable sectors to different types of unbounded increase in critical and unstable regions. The latter lead, respectively, to logarithmic and linear growth of the entanglement entropy with time. It is also shown that entanglement can be controlled by tuning  the frequency, such that it can be increased, kept constant, or returned to a vanishing value with just stepwise frequency variations. Exact asymptotic expressions for the entanglement entropy in the different dynamical regimes are provided.","palabras_clave":"Entanglement|Harmonic modes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39594,"idioma_id":4,"titulo":"Effects of Spray Drying Conditions on the Stability and Antioxidant Properties of Spray Dried Soluble Maté","resumen":"Abstract: The aim of this research was to evaluate the  stability of spray-dried soluble maté (Ilex paraguariensis)  and its total polyphenol content determined with the  Folin?Ciocalteu assay, after it was elaborated with three  different maltodextrin concentrations (0, 7.05 and 14.10%  w\/v) using experimental data of water activities and glass  transition temperatures. Adsorption isotherms were determined  for these three materials at 25°C between water  activity values (aw) of 0.1 and 0.85 (resulting in values of  water content between 0.04 and 0.33 g of water\/g of dried  solid). Glass transition temperatures varied from 15 to 52°C.  At room temperature powder containing 14.10% of maltodextrin  at aw¼0.55 was below the glass transition temperature,  while the two other compositions were below  their Tg and stable at aw¼0.40. In the spray drying conditions  analyzed, the loss of polyphenolic compounds is  negligible. The total polyphenol content varied between 28  and 45 chlorogenic acid equivalents (g % dry powder).","palabras_clave":"Ilex paraguariensis|glass transition|antioxidant capacity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39595,"idioma_id":5,"titulo":"Las sociologías pragmático-pragmatistas puestas a prueba en América Latina","resumen":"La producción sociológica latinoamericana siempre osciló entre una suerte de colonialismo cultural y una reivindicación autonómica regional. Con tendencia a asimilar teorías producidas en otras realidades, la producción sociológica latinoamericana difícilmente salió de dicha confrontación. Así, la demanda de simetría siempre era atravesada por estos ejes antagónicos: una producción local ajustada a una realidad periférica, pero de escasa universalidad, y una producción central que pretende universalidad a fuerza de exportar sus categorías analíticas. Este artículo pretende plantear un primer diálogo entre un enfoque no-dogmático y una realidad diversa. Las perspectivas pragmático-pragmatistas recogen una tradición teórica socio-filosófica sensible a las diferencias y un enfoque metodológico despojado de a prioris que carguen en demasía el análisis de la situación concreta.En primer lugar, presentaremos algunas características epistemológicas y metodológicas de estas perspectivas sociológicas. En segunda instancia, nos focalizaremos sobre ciertos aspectos de dos propuestas específicas: la sociología pragmática de Luc Boltanski sobre la construcción de affaires y&nbsp; la perspectiva pragmatista de Daniel Cefaï sobre la construcción de problemas públicos. Frente a ambas propuestas, orientadas a analizar la problematización pública de ciertas cuestiones sociales, relevaremos el tipo de diálogo existente con la realidad latinoamericana.","palabras_clave":"Sociología pragmática de los affaires|Sociología pragmatista de los problemas públicos|Abordajes metodológicos|Estudios latinoamericanos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39596,"idioma_id":4,"titulo":"Plum  Pox Virus in Japanese Plum  from Argentina: Serological Detection and Molecular Characterization of an Isolate from cv. Red Beauty","resumen":"A Plum pox virus (PPV) isolate detected in a Japanese plum orchard in Pocito (San Juan, Argentina) was transmitted mechanically to Prunus tomentosa and Nicotiana benthamiana. DAS-ELISA and DASI-ELISA indicated the virus presence and serological relationship with D-strain isolates; IC-RT-PCR amplified a 1.2-kb fragment of the virus genome encoding the CP-3&#8242; nc region. The analysis of the sequence showed the presence of the DAG motif at the 5&#8242; end of the capsid protein and the Rsa I and Alu I sites at the 3&#8242; end. The phylogenetic relationships and multiple alignment with PPV isolates from NCBI database indicated greatest (+98%) homology with the D strain and close identity with MNAT1 (AF360579) USA peach isolate. The sequence analysed showed two amino acid mutations towards the 5&#8242; N-terminus of CP (the most variable region) with respect to a consensus of PPV D-strain isolates. This is the first molecular characterization of 3&#8242;terminal genome region of PPV isolate to confirm D strain in a Japanese plum from Argentina.","palabras_clave":"phylogenetic relationship|Plum pox virus|Prunus salicina cv Red Beauty|sharka"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39597,"idioma_id":4,"titulo":"Characterization of gross composition, energy value and fatty acid profile of lowland tapir (Tapirus terrestris) milk during different periods of lactation.","resumen":"We evaluated gross composition, energy value, and fatty acid profile of colostrum, transitional, and mature milk of lowland tapir (Tapirus terrestris (L., 1758)) from Argentina. Samples were obtained from six healthy animals kept in captive or semicaptive conditions. Protein content varied over time from 6 to 19 g\/100 g of milk; carbohydrates varied from 2.4 to 5.4 g\/100 g of milk; fat varied from 2.4 to 17.3 g\/100 g of milk. Energy value also varied over time, with colostrum having the highest value.Fatty acid profile revealed a unique pattern in tapir milk, characterized by the presence of higher amounts of lauric, myristic, and pentadecanoic acids than in milk from other equids. Traces of conjugated linoleic acid (CLA) were measured, being the only trans fatty acid detected in tapir milk. Neither butyric acid (C4:0) nor fatty acids longer than C18 were found in tapir milk. The characteristics of tapir milk include high concentration of fat, caseins, and whey proteins. Gross composition and saturated fatty acid to unsaturated fatty acid (SFA\/UFA) ratio of tapir milk were more similar to that of horse milk than rhinoceros milk. The present study sheds light on tapir fatty acid metabolism and on nutritional requirements of their newborns, which can be used to improve conservation and management strategies. Furthermore, different periods of lactation were evaluated in this species for the first time, thus contributing to the general knowledge of milk from other members of the order Perissodactyla","palabras_clave":"TAPIRUS TERRESTRIS|LOWLAND TAPIR|ENDANGERED SPECIES|MILK|FATTY ACID PROFILE|ENERGY VALUE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39598,"idioma_id":5,"titulo":"Telomerasa y telómero: su estructura y dinámica en salud y enfermedad","resumen":"La telomerasa es la enzima responsable del mantenimiento de la longitud de los telómeros mediante la adición de secuencias repetitivas ricas en guanina, y su actividad se observa principalmente en gametos, células madre y células tumorales. En las células somáticas humanas el potencial de proliferación es limitado, alcanzando la senescencia luego de 50-70 divisiones celulares, debido a que la ADN polimerasa no es capaz de copiar el ADN en los extremos de los cromosomas. Por el contrario, en la mayoría de las células tumorales el potencial de replicación es ilimitado debido al mantenimiento de la longitud telomérica dado por la telomerasa. Los telómeros tienen proteínas adicionales que regulan la unión de la telomerasa. De la misma manera la telomerasa también se asocia con un complejo de proteínas que regulan su actividad. Este trabajo se centra en la estructura y función del complejo telómero\/telomerasa y a cómo las alteraciones en su comportamiento conducen al desarrollo de diversas enfermedades, principalmente cáncer. El desarrollo de inhibidores del sistema telómero \/ telomerasa podría ser un blanco con posibilidades prometedoras.","palabras_clave":"TELÓMERO|CÁNCER|ACTIVIDAD|TELOMERASA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39599,"idioma_id":4,"titulo":"On the evolution of the momentarily static radiation free data in the Apostolatos - Thorne cylindrical shell model.","resumen":"In this paper we study the evolution of the ´Momentarily Static and Radiation Free´ (MSRF) initial data for the Apostolatos?Thorne cylindrical shell model. After briefly reviewing the equations of motion, the definition of the MSRF initial data and of its relation to the static solution that corresponds to the given conserved intrinsic parameters of the shell, we show that for MSRF data the initial acceleration of the shell is always directed towards the static radius. We analyse in detail the relation between the parameters characterizing the configuration corresponding to the initial data and those for the assumed final static configuration, and show that, once the appropriate properties of the solutions of the cylindrical wave equation are taken into account, there is a priori no conflict for any choice of initial MSRF data, in contrast with some recent results of Nakao, Ida and Kurita. To obtain a more detailed description of the evolution we consider the case where the problem can be analysed in the linear approximation, and show that the evolution is stable in all cases. The possible form of the approach to the final static configuration is also analysed. We find that this approach is very slow, with an inverse logarithmic dependence on time at fixed radius. Given the absence of analytic solutions for the problem, we introduce a numerical computation procedure that allows us to visualize the explicit form of the evolution of the shell and the gravitational field up to large times. The results are in agreement with the qualitative behaviour conjectured by Apostolatos and Thorne, with an initial damped oscillatory stage, but we find that these oscillations are not about the final static radius but rather about a position that approaches slowly that of the static final state, as indicated by our analysis. We also include one appendix, where we review some properties of the solutions of the cylindrical wave equation, and prove the existence of solutions with vanishing initial value for r > R0, (R0 > 0 some finite constant), that approach a constant value for large times. This result is crucial for the proof of compatibility of arbitrary MSRF initial data and a final static configuration for the system. In a second appendix we discuss in detail the reasons for the discrepancy between our results and some aspects of the related work by both Apostolatos and Thorne, and by Nakao, Ida and Kurita.","palabras_clave":"Radiation|Cylindrical|Shell"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39600,"idioma_id":4,"titulo":"Cyclic AMP efflux, via MRPs and A1 adenosine receptors, is critical for bovine sperm capacitation","resumen":"Sperm capacitation has been largely associated with an increase in cAMP, although its relevance in the underlying mechanisms of this maturation process remains elusive. Increasing evidence shows that the extrusion of cAMP through multidrug resistance associated protein 4 (MRP4) regulates cell homeostasis not only in physiological but also in pathophysiological situations and studies from our laboratory strongly support this assumption. In the present work we sought to establish the role of cAMP efflux in the regulation of sperm capacitation. Sperm capacitation was performed in vitro by exposing bovine spermatozoa to bicarbonate 40 and 70 mM; cAMP; probenecid (a MRPs general inhibitor) and an adenosine type 1 receptor (A1 adenosine receptor) selective antagonist (DPCPX). Capacitation was assessed by chlortetracycline assay and lysophosphatidylcholine-induced acrosome reaction assessed by PSA-FITC staining. Intracellular and extracellular cAMP was measured by radiobinding the regulatory subunit of PKA under the same experimental conditions. MRP4 was detected by western blot and immunohistochemistry assays. Results showed that the inhibition of soluble adenylyl cyclase significantly inhibited bicarbonate-induced sperm capacitation. Furthermore, in the presence of 40 and 70 mM bicarbonate bovine spermatozoa synthesized and extruded cAMP. Interestingly, in the absence of IBMX (a PDEs inhibitor) cAMP efflux still operated in sperm cells, suggesting that cAMP extrusion would be a physiological process in the spermatozoa complementary to the action of PDE. Blockade of MRPs by probenecid abolished the efflux of the cyclic nucleotide resulting not only in the accumulation of intracellular cAMP but also in the inhibition of bicarbonate-induced sperm capacitation. The effect of probenecid was abolished by exposing sperm cells to cAMP. The high-affinity efflux pump for cAMP, MRP4 was expressed in bovine spermatozoa and localized to the midpiece of the tail as previously reported for soluble adenylyl cyclase and A1 adenosine receptor. Additionally, blockade of A1 adenosine receptor abolished not only bicarbonate-induced sperm capacitation but also that stimulated by cAMP. Present findings strongly support that cAMP efflux, presumably through MRP4, and the activation of A1 adenosine receptor regulate some events associated with bicarbonate-induced sperm capacitation, and further suggest a paracrine and\/or autocrine role for cAMP.","palabras_clave":"cAMP|SPERMATOZOA|CAPACITATION|MRP4"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39601,"idioma_id":4,"titulo":"Molecular identification, morphological characterization and new insights into the ecology of larval Pseudoterranova cattani in fishes from the Argentine coast with its differentiation from the Antarctic species, P. decipiens sp. E (Nematoda: Anisakidae)","resumen":"Larvae of the genus Pseudoterranova constitute a risk for human health when ingested through raw or undercooked fish. They can provoke pseudoterranovosis in humans, a fish-borne zoonotic disease whose pathogenicity varies with the species involved, making their correct specific identification a necessary step in the knowledge of this zoonosis. Larvae of Pseudoterranova decipiens s.l. have been reported in several fish species from off the Argentine coasts; however, there are no studies dealing with their specific identification in this region. Here, a genetic identification and morphological characterization of larval Pseudoterranova spp. from three fish species sampled from Argentine waters and from Notothenia coriiceps from Antarctic waters was carried out. Larvae were sequenced for their genetic\/molecular identification, including the mitochondrial cytochrome c oxidase subunit II (mtDNA cox2), the first (ITS-1) and the second (ITS-2) internal transcribed spacers of the nuclear ribosomal DNA, and compared with all species of the P. decipiens (sensu lato) species complex (sequences available in GenBank). Further, adults of Pseudoterranova spp. from the definitive host, the southern sea lion, Otaria flavescens, from Argentine and Chilean coasts were sequenced at the same genes. The sequences obtained at the ITS-1 and ITS-2 genes from all the larvae examined from fish of Argentine waters, as well as the adult worms, matched 100% the sequences for the species P. cattani. The sequences obtained at mtDNA cox2 gene for Antarctic larvae matched 99% those available in GenBank for the sibling P. decipiens sp. E. Both MP and BI phylogenetic trees strongly supported P. cattani and P. decipiens sp. E as two distinct phylogenetic lineages and depicted the species P. decipiens sp. E as sister taxon to the remaining taxa of the P. decipiens complex. Larval morphometry was similar between specimens of P. cattani from Argentina, but significantly different from those of P. decipiens sp. E, indicating that larval forms can be distinguished based on their morphology. Pseudoterranova cattani is common and abundant in a variety of fish species from Chile, whereas few host species harbour these larvae in Argentina where they show low levels of parasitism. This pattern could arise from a combination of factors, including environmental conditions, density and dietary preferences of definitive hosts and life-cycle pathways of the parasite. Finally, this study revealed that the life-cycle of P. cattani involves mainly demersal and benthic organisms, with a marked preference by large-sized benthophagous fish.","palabras_clave":"Anisakidae|Pseudoterranova;|Argentina|Molecular identification"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39602,"idioma_id":4,"titulo":"Nupela species (Naviculales: Bacillariophyceae) from Colombian lowland waters including N. acaciensis nov. sp. and N. catatumbensis nov. sp.","resumen":"Abstract: The genus Nupela comprises ca. 50 species that generally have a distribution restricted by bioclimatic frontiers. As part of an integrated analysis of the diatom flora of Colombia, in this study we focused our interest on the genus Nupela from lowland waters. Periphyton samples were collected from 150 sites of lotic water bodies in Colombia, taking into account hidrogeomorfological variability. In each sampling station, periphyton samples were obtained by scraping, and temperature, pH, dissolved oxygen and conductivity variables were measured. Samples were processed by both light microscopy (LM; Carl Zeiss Axio Scope.A1) and scanningelectron microscopy (SEM; FEI-Quanta 450 and a Jeol JSM-6360 LV). The genus Nupela was found in 28 sites. Five taxa were identified, described and illustrated from tropical or subtropical environments: N. lesothensis, N. praecipua y N. subpallavicinii; these were new records for Colombia, and N. acaciensis and N. catatumbensis two new species for science. N. acaciensis is characterized by raphe branches of both valves equally long combined with cymbelloid symmetry, striae built by 2 transapically elongated areolae that delimit a longitudinal line at each hemivalve. N. catatumbensis is characterized by the presence of a well developed raphe in both valves; valves lanceolate with subcapitated to capitated ends and cymbelloid symmetry, striae built by 3-4 transapically elongated areolae, interestriae elevated as transapical ribs and internal proximal raphe ends hook-shaped. The genus Nupela was widely distributed in the studied basins but showed different distribution patterns: N. acaciensis and N. subpallavicini had a restricted distribution, while N. catatumbensis, N. lesothensis and N. praecipua had a wider distribution, and were collected in sites with significant variations in their ecomorphology, altitude, temperature, pH and electrolyte content.","palabras_clave":"NUPELA|NUPELA ACACIENSIS|NUPELA CATATUMBENSIS|DIATOM|BACILLARIPHYCEAE|NEOTROPICS|COLOMBIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39603,"idioma_id":4,"titulo":"Biochemical characterization of Macrocystis pyrifera and Undaria pinnatifida (Phaeophyceae) in relation to their potentiality as biosorbents","resumen":"Undaria pinnatifida and Macrocystis pyrifera from Patagonia were characterized in terms of the alginate, protein, total carbohydrate and organic matter content, cation exchange capacity and acid-base properties to assess the suitability of both species as potential biosorbents of metals. Environmental Scanning Electron Microscopy equipped with Energy Dispersive X-ray microanalysis system, Fourier Transform Infrared Spectroscopy (FT-IR) and Brunauer, Emmett and Teller surface area analysis were also applied for characterization. The results showed that U. pinnatifida had higher percentage of organic matter, alginate and protein and a larger specific surface area than M. pyrifera, although the later exhibited a higher ionic exchange capacity. The groups with a weak acid behavior represented 84% and 97% of the total acid groups in M. pyrifera and U. pinnatifida, respectively. FT-IR analysis confirmed the presence of different chemical groups such as sulfonate in both biomaterial M. pyrifera and U. pinnatifida. Besides, Zn(II) adsorption capacity was different among different parts of the thallus of each species. The difference founded in the physicochemical properties of both algae could affect their biosorption capacities","palabras_clave":"BIOCHEMICAL CHARACTERIZATION|BIOSORPTION|MACROCYSTIS PYRIFERA|UNDARIA PINNATIFIDA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39604,"idioma_id":4,"titulo":"CLEAs  of  Candida  antarctica  lipase B  (CALB)  with  a  bovine  serum  albumin  (BSA)  cofeeder  core:  Study  of  their  catalytic  activity","resumen":"Highly active CALB cross-linked enzyme aggregates (CLEAs) were synthesized using a layered methodology based on the synthesis of a cross-linked protein cofeeder core over which an external layer of lipase was later cross-linked. The layered CALB CLEAs were characterized in terms of their catalytic activity in three different test reactions: esterification of oleic acid and ethanol in absence of solvents, esterification of oleic acid and heptanol in organic medium, and hydrolysis of triolein in emulsioned medium. The impact of the cross-linker\/protein mass ratio on CLEAs activity, and its evolution with storage time were evaluated in the solventless synthesis of ethyloleate. The amount of cross-linker used showed to be a key parameter for the evolution of the catalytic activity of CLEAs during storage. Under the best conditions found, hyperactivated CALB CLEAs with up to 188% of recovered activity in ethyl oleate synthesis were obtained. In terms of hydrolytic activity mature layered CALB CLEAs showed a retained activity of 68%. The assay of dried mature layered CALB CLEAs in heptyl oleate synthesis showed catalytic activities much higher than the one exhibited by free CALB, reaching 1 h-fatty acid conversions of 14% and 2%, respectively. The high catalytic activity shown by layered CALB CLEAs, suggests that they are an interesting alternative specially for the catalysis of fatty acid esterifications in both organic and solventless medium","palabras_clave":"BIOCATALYSIS|LIPASE|IMMOBILIZATION|ENZYME ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39605,"idioma_id":4,"titulo":"Seed water concentration and the accumulation of protein and oil during soybean seed development","resumen":"Seed development is partitioned into a ?lag? phase, a ?seed filling? phase, and a ?maturation? phase. Transitions between phases correspond to seed water concentration (WC) values that are fairly consistent within species. For soybean (Glycine max L.), linear seed filling begins at approximately 85% (WCL) and maximum dry weight is attained at approximately 60% (WCM). While such WC values benchmark the progress of seed development, their utility for establishing onset and duration of individual seed chemical component accumulation is not known. Our objectives were (i) to determine WCL and WCM for seed protein, oil, and residual (mostly carbohydrates), (ii) to assess stability across genotypes and environments, and (iii) to investigate their relationship with the duration of accumulation. The WCL and WCM for oil, protein, and residual were significantly different. Values were higher for residual and lower for oil. Since seeds desiccate throughout their development, residual accumulation was initiated first, followed by protein, then by oil. The parameter WCL was more stable across genotypes than was WCM. Genotypes with lower WCM values had a longer duration of component accumulation. Increasing assimilate supply per seed decreased WCL for all seed components, but had little impact on WCM. Our results indicate that a water relations framework can be used to characterize accumulation patterns of individual seed components across genotypes and environments, providing a common basis for modeling the composition of soybean seeds.","palabras_clave":"Seed development|Seed composition|Seed protein|Seed oil"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39606,"idioma_id":4,"titulo":"Messages Do Diffuse Faster Than Messengers: Reconciling disparate estimates of the morphogen Bicoid diffusion coefficient","resumen":"The gradient of Bicoid (Bcd) is key for the establishment of the anterior-posterior axis in Drosophila embryos. The gradient properties are compatible with the SDD model in which Bcd is synthesized at the anterior pole and then diffuses into the embryo and is degraded with a characteristic time. Within this model, the Bcd diffusion coefficient is critical to set the timescale of gradient formation. This coefficient has been measured using two optical techniques, Fluorescence Recovery After Photobleaching (FRAP) and Fluorescence Correlation Spectroscopy (FCS), obtaining estimates in which the FCS value is an order of magnitude larger than the FRAP one. This discrepancy raises the following questions: which estimate is 'correct??; what is the reason for the disparity; and can the SDD model explain Bcd gradient formation within the experimentally observed times? In this paper, we use a simple biophysical model in which Bcd diffuses and interacts with binding sites to show that both the FRAP and the FCS estimates may be correct and compatible with the observed timescale of gradient formation. The discrepancy arises from the fact that FCS and FRAP report on different effective (concentration dependent) diffusion coefficients, one of which describes the spreading rate of the individual Bcd molecules (the messengers) and the other one that of their concentration (the message). The latter is the one that is more relevant for the gradient establishment and is compatible with its formation within the experimentally observed times.","palabras_clave":"bicoid|diffusion|FCS|FRAP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39607,"idioma_id":4,"titulo":"Low X-ray luminosity galaxy clusters - II. Optical properties and morphological content at 0.18 < z < 0.70","resumen":"This is the second of a series of papers on low X-ray luminosity galaxy clusters, in which we present the r´, g´ and i´ photometry obtained with Gemini Multi-Object Spectrograph IMAGE at Gemini North and South telescopes for seven systems in the redshift range of 0.18 to 0.70. Optical magnitudes, colours and morphological parameters, namely, concentration index, ellipticity and visual morphological classification, are also given. At lower redshifts, the presence of a well-defined red cluster sequence extending by more than 4 mag showed that these intermediate-mass clusters had reached a relaxed stage. This was confirmed by the small fraction of blue galaxy members observed in the central regions of ?0.75 Mpc. In contrast, galaxy clusters at higher redshifts had a less important red cluster sequence. We also found that the galaxy radial density profiles in these clusters were well fitted by a single power law. At 0.18 < z < 0.70, we observed an increasing fraction of blue galaxies and a decreasing fraction of lenticulars, with the early-type fraction remaining almost constant. Overall, the results of these intermediate-mass clusters are in agreement with those for high-mass clusters.","palabras_clave":"galaxies: clusters: general|galaxies: fundamental parameters|galaxies: photometry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39608,"idioma_id":4,"titulo":"A new genus of sigmodontine rodent from eastern Brazil and the origin of the tribe Phyllotini","resumen":"We describe a new living genus and species of Sigmodontinae currently only known from the Brazilian National Park Sempre Vivas, Minas Gerais State. This rodent is characterized by a unique combination of traits that include, among others, a long tail, with its distal tip (approximately 2.5 to 5 cm) entirely white; skull with domed profile; long rostrum with an incipient rostral tube; and noticeable small brachyodont molars with reduced mesolophs and mesostyles present on the 1st and 2nd upper molars. Cladistic analyses of molecular (1 mitochondrial and 1 nuclear marker) and morphological characters indicate that the new genus belongs to the Phyllotini and is sister to the remainder genera of this tribe. However, contrary to other known phyllotines, the new genus shows vestigial mesolophs and mesostyles. Phyllotines are widespread in open areas, in particular desert and semideserts, mostly in the western portion of South America. The new genus described herein expands the diversity of the tribe and suggests an ancient event of diversification in eastern Brazil.","palabras_clave":"BRAZIL|CALOMYS|CERRADO|CRICETIDAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39609,"idioma_id":4,"titulo":"A new species of the tetraploid vizcacha rat Tympanoctomys (Caviomorpha, Octodontidae) from Central Patagonia, Argentina","resumen":"A new living species of the desert-adapted tetraploid rodent Tympanoctomys (Caviomorpha, Octodontidae) is described. The new form is restricted to the type locality in Chubut Province, central Patagonia, Argentina, although is known from at least 4 additional Holocene-aged localities along the middle and lower valley of the Chubut River. Tympanoctomys sp. nov. is smaller than the living T. barrerae, its general coloration is yellowish(reddish in T. barrerae) and its tail is equal to ~43?50% of head and body length (~49?53% in T. barrerae). Its skull and dentition are characterized by a unique combination of morphological traits, including narrow and posteriorly acuminate nasals (broad and barrel-shaped in T. barrerae), supraoccipital not laterally expanded(expanded in T. barrerae), and 8-shaped lower 3rd molar (comma-shaped in T. barrerae and ?T. cordubensis). Morphometric and genetic evidence supports the specific distinction of this Patagonian endemic Tympanoctomys, also characterized by smaller sperm than T. barrerae. The reduced range of the new species, coupled with its recent extinction from the Chubut River valley and the potential impact of large uranium mining projects in central Patagonia, suggest that this species faces a severe extinction risk in the short term.","palabras_clave":"PIPANACOCTOMYS|SALINOCTOMYS|OCTODONTIDS|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39610,"idioma_id":4,"titulo":"Molecular phylogenetics of mouse opossums: new findings on the phylogeny of Thylamys (Didelphimorphia, Didelphidae)","resumen":"The  mouse opossums of the genus Thylamys constitute  a group of species mainly adapted to open xeric-like habitats and restricted to  the southern portion of South America. We used molecular data (mitochondrial  and nuclear sequences) to evaluate the phylogenetic and biogeographical relationships  of all currently known living species of the genus, recognizing a new taxon  from the middle and high elevations of the Peruvian Andes and evaluating the phylogenetic  structuring within T. pallidior and T. elegans, as well as the validity of T. sponsorius, T. cinderella and T. tatei,  and the haplogroups recognized within T.  pusillus. Our results confirm the monophyly of the genus and that the  Caatinga and the Cerrado inhabitants Thylamys  karimii and T. velutinus are the  most basal species in the radiation of Thylamys.  We also calibrated a molecular clock which hypothesized a time of origin of the  genus of about 24 My, with most species differentiating in middle and late  Miocene and Plio-Pleistocene times of South America.","palabras_clave":"TAXONOMY|SOUTH AMERICA|MOLECULAR DATA|THYLAMYS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39611,"idioma_id":4,"titulo":"Congruence between morphology and phylogeography in the Patagonian long-clawed mouse Chelemys macronyx (Rodentia, Cricetidae)","resumen":"Abstract: Chelemys macronyx is a medium-sized, long clawed sigmodontine of fossorial habits, distributed between 33 ¡ã 20 ¡ä and 51 ¡ã 30 ¡ä S in the central and southern Andes of Argentina and Chile. Phylogeographic studies based on the analysis of mitochondrial DNA showed that this rodent has a shallow genealogy geographically structured into two main clades: one in the northern part of its range, at high-Andean localities in the Argentinean provinces of Mendoza and northern Neuqu¨¦n, and the other covering medium- to low-elevation areas from northwestern Neuqu¨¦n to southern Chile and Argentina. Qualitative and quantitative morphological characters show the existence of two main morphotypes of C. macronyx. Northern populations are characterized by a mesopterygoid fossa rounded at its anterior border and by a large and nearly circular foramen ovale, whereas in central and southern populations the mesopterygoid fossa is quadrate with an ovate to piriform foramen ovale. The described morphological variation is in congruence with the phylogeographic patterns identified by molecular markers. In light of these results, we suggest a simplified taxonomic arrangement on which two subspecies are recognized within C . macronyx, a northern one and a southern one for which the names C. m. macronyx and C. m. vestitus correspond, respectively. ","palabras_clave":"ABROTRICHINI|FOSSORIAL RODENTS|MORPHOLOGY|SIGMODONTINAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39612,"idioma_id":4,"titulo":"Kunsia tomentosus","resumen":"Abstract: Kunsia tomentosus (Lichtenstein, 1830), the Woolly Giant Rat, is a semifossorial cricetid typically associated to the Cerrado and Beni domains in central South America. Kunsia was recently revised and includes only 1 species. It is the largest extant sigmondontine and is readily distinguishable by its large size, a body covered with dark-gray pelage, dense and harsh fur, short tail, short limbs, bicolored pes, and long, powerful claws. Inhabits primarily open grasslands and savannas from central and south-western Brazil and eastern Bolivia. K. tomentosus presently is not considered threatened, however some populations are in localities under high human impacts and westernmost populations have presumably been extirpated in the past 2 centuries.","palabras_clave":"AKODONTINI|BOLIVIA|BRAZIL|CERRADO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39613,"idioma_id":4,"titulo":"Study of lead levels in soils by weathering of metallic Pb bullets used in dove hunting in Córdoba, Argentina","resumen":"A study of level of Pb in soils of the center-north of the Province of Córdoba, a worldwide recognized tourist region for dove hunting, was performed in this work. The native forest of the region has a great population of doves associated with the grainproductive fields of the surrounding. Contamination of soils due to hunting activities is regulated by national and local norms. The Córdoba Environmental Secretary by resolution no. 1115\/2011 approved a new regulation that categorizes this activity as generator of Y31 (Pb) industrial waste. Lead from pellets alloy is deposited on the soil of the shooting fields. Samples were taken at depth of 50mm from 315 pits referenced by GPS in accordance with local environmental authorities as well as the hunting outfitters companies. Sampling sites are distributed between parallels 31 °S (S31) up to 30 °S (S30) and between meridians W64 up to W63. Soils samples were analyzed by X-ray fluorescence spectroscopy while Pb bullets were analyzed by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The average concentration obtained for Pb in dry soil sieved (200 mesh) was 80 ppm. Powder XRD patterns of crust material removed from the corroded surface of weathered bullets were obtained. Three Pb mineral compounds were identified by XRD analysis and also studied by optical microscopy and SEM.","palabras_clave":"metallic Pb|dove hunting"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39614,"idioma_id":4,"titulo":"In situ formation of coloured M(II)-doped  Zn2SiO4-willemite in ceramic glazes (M=Mn, Co, Ni, Cu)","resumen":"The family of M(II) substituted ZnO-wurtzite was investigated as potential new ceramic pigments. When MxZn1&#8722;xO or (MM´)xZn1&#8722;xO with (M\/M´=Mn, Co, Ni, Cu) oxides are incorporated to industrial frits the development of new colour hues is observed. This is attributed to the in situ formation of coloured M(II)-doped Zn2SiO4-willemite in ceramic glazes. The pigments were prepared by solid state reaction through the traditional ceramic route. Prior to enamelling, the materials were characterized by XRD analysis and FTIR spectroscopy. The colour performance and technological properties of the enamels were evaluated by enamelling in batches containing 5% weight with a transparent frit, representative of single firing industrial procedures, and submitting them to thermal treatment at 1000&#730;C. The colours obtained, once the glazes were formed are attributed mainly to the formation of crystalline Zn2SiO4 within the glassy matrix, when chromophore M(II) ions enters into the tetrahedral coordination Zn(II) site available in willemite. The colorimetric CIELab parameters measured are in good agreement with the structural and spectroscopic analysis. The colour of some glassy coatings was interpreted by analyzing the reflectance UV-visible electronic spectra of the samples. This study demonstrates that this family of pigment is capable of forming its own Zn-based crystals in a conventional transparent ceramic frit giving rise to a wide palette of colours. When Mn, Co, Ni and Cu are present in the Zn(II) site light brown, deep blue, pale yellow and green, are achieved respectively. Furthermore the simultaneous doping with a combination MM´ results in various nice new shades of colours, enlarging the palette of green, yellow, brown and blue hues. The homogeneity of the enamels was confirmed by SEM-EDX microscopy. These materials are promising for ceramic applications since a low amount of pigment would be necessary to achieve intense coloration.","palabras_clave":"M(II)-ZnO|COLOUR|GLASSY COATING|SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39615,"idioma_id":4,"titulo":"comTAR: a web tool for the prediction and characterization of conserved microRNA targets in plants","resumen":"MOTIVATION:  MicroRNAs (miRNAs) are major regulators of gene expression in plants and animals. They recognize their target messenger RNAs (mRNAs) by sequence complementarity and guide them to cleavage or translational arrest. So far, the prediction of plant miRNA-target pairs generally relies on the use of empirical parameters deduced from known miRNA-target interactions.    RESULTS:  We developed comTAR, a web tool for the prediction of miRNA targets that is mainly based on the conservation of the potential regulation in different species. We used data generated from a pipeline applied to transcript datasets of 33 angiosperms that was used to build a database of potential miRNA targets of different plant species. The database contains information describing each miRNA-target pair, their function and evolutionary conservation, while the results are displayed in a user-friendly interface. The tool also allows the search using new miRNAs.    AVAILABILITY AND IMPLEMENTATION:  The Web site is free to all users, with no login requirements, at http:\/\/rnabiology.ibr-conicet.gov.ar\/comtar.","palabras_clave":"Bioinformatics|microRNA|prediction|target"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39616,"idioma_id":4,"titulo":"Hydrological links in South Eastern South America: Soil Moisture memory and coupling within a hot spot","resumen":"Southeastern South America has been identified as a hot spot of soil moisture and evapotranspiration coupling efficiency during austral summer in a previous study. Here, hydrological processes such as coupling and memory of soil moisture, evapotranspiration and precipitation and the links between these variables are discussed on the daily time scale over this region. The correlations between surface variables, rainfall persistence and soil moisture memory are discussed over three subregions selected on basis of their coupling efficiency and mean daily intensity of precipitation. The relationship between surface climate and land cover is qualitatively assessed. The memory, or statistical persistence, is longer and has a more robust spatial pattern for the root zone than for the top soil moisture. Where the coupling efficiency between soil moisture and evapotranspiration is high, the evapotranspiration is regulated by soil moisture conditions independently on the intensity of precipitation, whereas in a region with low coupling efficiency and high intensity, the evapotranspiration is regulated by the atmosphere. The coupling efficiency is in general related to the memory of the root-zone layer, since the soil state is modified when the soil moisture and the atmosphere interact, resulting in an anticorrelation between these metrics. The persistence of rainfall is another factor that modulates the memory. Nevertheless, there are some areas around the La Plata River where both the coupling efficiency and the memory are relatively high, such as Uruguay and the northeast of Argentina, where an improvement of soil moisture initial conditions could improve predictability of surface variables on a monthly timescale.","palabras_clave":"soil moisture memory|evapotranspiration|precipitation|Southeastern South America|La Plata Basin|regional climate modelling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39617,"idioma_id":4,"titulo":"Understanding the low breeding success in Greater Rheas populations through an energy budget model","resumen":"We propose an individual-based energy budget model of the Greater Rhea (Rhea americana)   with the purpose of analyzing the population´s recruitment. One   remarkable characteristic of this species is that female rheas lay eggs   communally and males incubate the eggs and care for the chicks without   the assistance of females.      The model is based on a   system of equations daily updating the weight of each bird as a function   of its ingestion rate and the energetic cost of its activity pattern.   Ingestion rate is calculated from field experiments. Daily energetic   costs are estimated from activity patterns observed in the field, taking   into account gender and factors that influence behavior (e.g.,   photoperiod, season). Concatenating daily model outputs, the weight   dynamics of an individual can be calculated over any given period of   time.      The possible factors that affect the   successful breeding of the Greater Rhea and therefore population growth   are analyzed using the model. Different reproductive strategies for each   gender are analyzed and the minimal body weight, and thus energy   reserves, that an individual needs to achieve for ensuring reproductive   success is determined. Model outputs show that the reproductive success   of males depends strongly on their body weight while females exhibit low   nutritional requirements for producing eggs. An analysis of model   outputs allows inferring that males in wild populations might not be   able to breed in consecutive years but could successfully breed every   other year. They also allow estimating the incidence that food   availability has on population growth. Management strategies that are   easy to implement in extensive and semi-extensive farms may allow   obtaining male individuals capable of breeding every year.","palabras_clave":"Rhea americana;|Quantitative modeling|Energy balance|Body weight dynamics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39618,"idioma_id":4,"titulo":"Targeting galectin-1-induced angiogenesis mitigates the  severity of endometriosis","resumen":"Endometriosis is characterized by the presence of endometrial tissue outside the uterus that causes severe pelvicpain and infertility in women of reproductive age. Although not completely understood, the pathophysiology of thedisease involves chronic dysregulation of inflammatory and vascular signalling. In the quest for novel therapeutictargets, we investigated the involvement of galectin-1 (Gal-1), an endogenous glycan-binding protein endowedwith both immunosuppressive and pro-angiogenic activities, in the pathophysiology of endometriotic lesions. Herewe show that Gal-1 is selectively expressed in stromal and endothelial cells of human endometriotic lesions. Usingan experimental endometriosis model induced in wild-type and Gal-1-deficient (Lgals1&#8722;\/&#8722;) mice, we showed thatthis lectin orchestrates the formation of vascular networks in endometriotic lesionsin vivo, facilitating their ectopicgrowth independently of vascular endothelial growth factor (VEGF) and the keratinocyte-derived CXC-motif(CXC-KC) chemokine. Targeting Gal-1 using a specific neutralizing mAb reduced the size and vascularized areaof endometriotic lesions within the peritoneal compartment. These results underline the essential role of Gal-1during endometriosis and validate this lectin as a possible target for the treatment of disease.","palabras_clave":"endometriosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39619,"idioma_id":4,"titulo":"Theoretical Study of the Electronic Spectrum of Disulfur Monoxide","resumen":"The near ultraviolet-visible absorption spectrum of disulfur monoxide ( S2O) has been theoreticallystudied by using the time-dependent density functional theory (TD-DFT) and the equation of motioncoupled-cluster singles and doubles approach (EOM-CCSD) combined with the AUG-cc-PVQZ basis set. From this, analytical expressions for the absorption coefficient over the 250 ? 340 nm range are reported for the first time. The computed molecular structure and the vibrational frequencies for the ground and third electronically excited state S2O (C 1A0), responsible of the observed spectrum, are compared with available data.","palabras_clave":"S2O|Absorption spectra|TD-DFT|EOM-CCSD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39620,"idioma_id":4,"titulo":"Remarks on Sedum thartii (Crassulaceae), an exotic species naturalized in Argentina","resumen":"Sedum thartii L.P. Hebert, a crassulacean plant that originates from Europe, was recently discovered in central Argentina.  This species occurs in mountainous habitats in the province of Córdoba; here we show diagnostic characters to aid its  identification and ecological features. A key of the species of Sedum in Argentina is also provided.","palabras_clave":"ALIEN FLORA|ARGENTINA|CHACO SERRANO|CÓRDOBA|CRASSULACEAE|SEDUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39621,"idioma_id":4,"titulo":"Weather and child health in rural Nigeria","resumen":"The effect of weather shocks on children´s anthropometrics is investigated using the two most recent rounds of the Nigeria Demographic and Health Survey (DHS). For this purpose, climate data for each DHS cluster are interpolated using daily weather station records from the national network. The findings reveal that rainfall shocks have a statistically significant and robust impact on child health in the short-run for both weight-for-height and height-for-age, and the incidence of diarrhoea. The impacts of weather shocks on health are of considerable magnitude; however, children seem to catch-up with their cohort rapidly after experiencing a shock. Finally, it appears that the impact of these shocks is the same for young boys and girls, which suggests that there is no gender-based discrimination in the allocation of resources within households.","palabras_clave":"weather shocks|climate change|health|Nigeria"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39622,"idioma_id":4,"titulo":"Genomic and phenotypic attributes of novel salinivibrios from stromatolites, sediment and water from a high altitude lake","resumen":"AbstractBackgroundSalinivibrios are moderately halophilic bacteria found in salted meats, brines and hypersalineenvironments. We obtained three novel conspecific Salinivibrio strains closely related to S.costicola, from Socompa Lake, a high altitude hypersaline Andean lake (approx. 3,800meters above the sea level).ResultsThe three novel Salinivibrio spp. were extremely resistant to arsenic (up to 200 mM As),NaCl (up to 15%), and UV-B radiation (19 KJ\/m2, corresponding to 240 minutes ofexposure) by means of phenotypic tests. Our subsequent draft genome ionsequencing andRAST-based genome annotation revealed the presence of genes related to arsenic, NaCl, andUV radiation resistance. The three novel Salinivibrio genomes also had the xanthorhodopsingene cluster phylogenetically related to Marinobacter and Spiribacter. The genomictaxonomy analysis, including multilocus sequence analysis, average amino acid identity, andgenome-to-genome distance revealed that the three novel strains belong to a new Salinivibriospecies.ConclusionsArsenic resistance genes, genes involved in DNA repair, resistance to extreme environmentalconditions and the possible light-based energy production, may represent important attributesof the novel salinivibrios, allowing these microbes to thrive in the Socompa Lake.Keywords","palabras_clave":"Arsenic|UV radiation|Xanthorhodopsin|Extreme environment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39624,"idioma_id":4,"titulo":"Electrophoretic deposition of ZnO nanostructures: Au nanoclusters on Si substrates induce self-assembled nanowire growth","resumen":"The present work reports the self-assembled growth of ZnO nanowires on silicon substrate with nano-meter sized Au clusters using electrophoretic deposition technique at room temperature without asacrificial template. A colloidal suspension of &#8776;5 nm sized ZnO nanoparticles dispersed in 2-propanolwas used (nanoparticle bandgap of 3.47 eV as determined from absorbance measurements). The resultsshow that the Au nanoclusters on the silicon substrate induce the self-assembly of the ZnO nanoparticlesinto vertically aligned ZnO nanowires. This effect is tentatively explained as being due to increased elec-tric field intensities near the Au nanoclusters during the electrophoretic deposition. Photoluminescencemeasurements reveal the presence of quantum confined excitons and a relatively low concentrationof deep defects in the nanowires. The electric field guided growth of semiconductor nanostructures atroom temperature has great industrial potential as it minimizes production costs and enables the use ofsubstrate materials not withstanding high temperatures.","palabras_clave":"ZnO NANOWIRES|ELECTROPHORETIC DEPOSITION|PHOTOLUMINESCENCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39626,"idioma_id":4,"titulo":"Selection of indigenous lactic acid bacteria to reinforce the intestinal microbiota of newly hatched chicken - relevance of in vitro and ex vivo methods for strains characterization","resumen":"Based on the natural benefits of the indigenous microbiota, lactic acid bacteria (LAB) from poultry origin were isolated from hens and broilers intestine, and their probiotic potential was further studied. The tolerance to digestion, adhesion, capture of a mannose-binding lectin, absence of virulent factors and antibiotic resistances were studied. Different in vitro and ex vivo assays were performed to select tolerant and adherent strains because standardized protocols have not been defined. Fourteen strains highly tolerant to gastrointestinal digestion were genetically identified. Hydrophobic surfaces were not requiredfor the bacterial adhesion and only nine strains adhered ex vivo to the intestinal mucosa. Three strains captured a lectin of the same specificity of Type-1 fimbriae. Virulence factors were absent but some strains evidenced multiple antibiotic resistances. These results provide bases for a future standardization of methods for the selection of probiotic strains intended to reinforce the microbiota of newly hatched chickens.","palabras_clave":"POULTRY|LACTIC ACID BACTERIA|PROBIOTIC|SELECTION PROTOCOLS|SAFETY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39627,"idioma_id":4,"titulo":"Photochemical reduction of U(VI) in aqueous solution in the presence of 2-propanol","resumen":"The efficiency of the photochemical reduction of uranyl (UO22+) (0.25 mM, pH 3) was analyzed in the absence and in the presence of 2-propanol (2-PrOH), evaluating the effect of anions (nitrate, acetate and perchlorate) and the use of quartz and glass photoreactors. Higher removals were observed with the quartz photoreactor; the best system was that starting from uranyl nitrate, where a 90% UO22 removal was attained after 15 min irradiation. In the absence of 2-PrOH, the acetate system was the only one where some U(VI) removal was observed (15% after 15 min in the quartz photoreactor) but, in the presence of the alcohol, the acetate system was the least reactive. In the irradiated uranyl systems, nitrate and acetate were consumed during the reaction, causing important effects on the conversion, while perchlorate was inactive. Uranium was removed from the system as a solid residue in the case of nitrate- (as U(IV)) and perchlorate-containing systems (as U(VI)), while it remained in solution in the case of the acetate systems. Mechanisms are proposed for the different conditions. The importance of nitrate as a reducing agent of uranium species has not been previously reported. The use of uranyl nitrate and short-near UV-vis light seems to be the most advisable way of removing uranyl from solutions in the form of a stable precipitate.","palabras_clave":"Photochemical reduction |uranium| 2-propanol"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39628,"idioma_id":4,"titulo":"GPGPU implementation of the BFECC algorithm for pure advection equations","resumen":"In the present work an implementation of the Back and Forth Error Compensation and Correction (BFECC) algorithm specially suited for running on General-Purpose Graphics Processing Units (GPGPUs) through Nvidia?s Compute Unified Device Architecture (CUDA) is analyzed in order to solve transient pure advection equations. The objective is to compare it to a previous explicit version used in a Navier-Stokes solver fully written in CUDA. It turns out that BFECC could be implemented with unconditional stable stability using Semi-Lagrangian time integration allowing larger time steps than Eulerian ones.","palabras_clave":"GPGPU|CUDA|BFECC|Semi-Lagrangian|Level-Set|Navier-Stokes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39629,"idioma_id":4,"titulo":"Drought effects on the early development stages of Panicum virgatum L.: Cultivar differences","resumen":"We studied the response to moderate drought and re-watering in 55-day-old plants of the lowland cv. Kanlow and the upland cv. Greenville. Plants were grown in a growth chamber; drought treatment was applied by water suppression until moderate stress was reached. The optimal harvest time was determined when the relative water content (RWC) in plants  reached an average of 60%. The effects of drought and recovering on growth (i.e. plant height and leaf number), antioxidant enzymes (SOD and CAT), abscisic, salicylic and jasmonic acids levels (ABA, SA, JA), and water stress related genes were analyzed. Drought induced a decrease in growth in cv. Greenville but not in Kanlow. Drought tolerance in cv.  Kanlow was correlated with higher antioxidant activities both in stress and recovery. Thus, we investigated stress hormones known to induce reactive oxygen species (ROS). ABA was the main hormone under stress, and increased higher in cv. Kanlow than in cv. Greenville. SA and JA basal levels were higher in well watered plants of cv. Kanlow. At gene levels,  RAB18 and RD22 overexpressed after 24 h of re-watering in cv. Kanlow, resembling a ?stress memory? mechanism described in other species. Further molecular markers of hormone effects (PR2) or drought (DREB2) well known in dicots seem not to be specific for Panicum virgatum. Overall, we found that cultivar Kanlow has an effective machinery of stress response, which makes it promising to be grown successfully in semi-arid regions.","palabras_clave":"Panicum virgatum   |Drought|Stress hormones |Stress marker genes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39630,"idioma_id":4,"titulo":"Making explosive cocktails: Recipes and costs of 20 Argentine crises from 1865 to 2004","resumen":"The objective of this paper is twofold. Firstly, we investigate what were the ?recipes? of the 20 Argentine currency crises from 1865 to 2004 using regression tree analysis, which is a non-parametric data classification technique. Secondly, we evaluate the costs of Argentina?s crises in terms of output losses and recovery time. We obtained three ?recipes? that constitute an early warning system. The most costly and frequent mix has two ?ingredients?: high Public Expenditures (% of GDP) and Current Account Deficit (% of GDP). The less  frequent and less costly mix consists of moderate Public Expenditures, Real Exchange Rate Overvaluation, and high International Interest Rates. Finally, the mix with intermediate costs and medium frequency is made up of five ingredients: moderate Public Expenditures, Real Exchange Rate Overvaluation, moderate  International Interest Rates, strong decline in Bank Deposits, and high ratio of Monetary Aggregate M2 to International Reserves.","palabras_clave":"CURRENCY CRISES|CLASSIFICATION TREE ANALYSIS|CRISES COSTS|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39631,"idioma_id":4,"titulo":"A Window into the Intoxicated Mind: Speech as an Index of Psychoactive Drug Effects","resumen":"Abused drugs can profoundly alter mental states in ways that may motivate drug use. These effects are usually assessed with self-report, an approach that is vulnerable to biases. Analyzing speech during intoxication may present a more direct, objective measure, offering a unique 'window' into the mind. Here, we employed computational analyses of speech semantic and topological structure after ±3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') and methamphetamine in 13 ecstasy users. In 4 sessions, participants completed a 10-min speech task after MDMA (0.75 and 1.5&#8201;mg\/kg), methamphetamine (20&#8201;mg), or placebo. Latent Semantic Analyses identified the semantic proximity between speech content and concepts relevant to drug effects. Graph-based analyses identified topological speech characteristics. Group-level drug effects on semantic distances and topology were assessed. Machine-learning analyses (with leave-one-out cross-validation) assessed whether speech characteristics could predict drug condition in the individual subject. Speech after MDMA (1.5&#8201;mg\/kg) had greater semantic proximity than placebo to the concepts friend, support, intimacy, and rapport. Speech on MDMA (0.75&#8201;mg\/kg) had greater proximity to empathy than placebo. Conversely, speech on methamphetamine was further from compassion than placebo. Classifiers discriminated between MDMA (1.5&#8201;mg\/kg) and placebo with 88% accuracy, and MDMA (1.5&#8201;mg\/kg) and methamphetamine with 84% accuracy. For the two MDMA doses, the classifier performed at chance. These data suggest that automated semantic speech analyses can capture subtle alterations in mental state, accurately discriminating between drugs. The findings also illustrate the potential for automated speech-based approaches to characterize clinically relevant alterations to mental state, including those occurring in psychiatric illness.","palabras_clave":"ECSTASY|MDMA|METHAMPHETAMINE|SPEECH|SEMANTIC ANALYSES|MACHINE LEARNING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39632,"idioma_id":4,"titulo":"The geometry of Expertise","resumen":"Theories of expertise, based on chunk and templates acquisition theories, suggest a differential geometric organization of perception between experts and novices. It is implied that expert representation is less anchored by spatial (Euclidean) proximity and may instead be dictated by the intrinsic relation in the structure and grammar of the specific domain of expertise. Here we set out to examine this hypothesis. We used the domain of chess which has been widely used as a tool to study human expertise. We reasoned that the movement of an opponent piece to a specific square constitutes an external cue and the reaction of the player to this 'perturbation' should reveal his internal representation of proximity. We hypothesized that naive players will tend to respond in more proximal squares than experts. Similarly, in terms of object representations, we hypothesized naive players will more likely focus on a specific piece and hence produce sequence of actions repeating movements of the same piece. We capitalized on a large corpus of data obtained from internet chess servers. Results showed that weaker players tend to 1) produce consecutive moves in proximal board locations,  2) move more often the same piece and 3) reduce the number of remaining pieces more rapidly, most likely to decrease cognitive load and mental effort. These three principles might reflect the effect of expertise on human actions in complex setups.","palabras_clave":"CHESS EXPERTISE|OBJECT REPRESENTATION|CHUNKS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39633,"idioma_id":4,"titulo":"Frequency analysis of PWM inverters with dead-time for arbitrary modulating signals","resumen":"The effect of dead-time on the spectrum of pulse-width modulated signals is analyzed in this paper. The study is valid for arbitrary, band-limited modulating signals, extending previous results in the literature. A simple distortion index is developed that can be used at the design stage to select dead-time or switching frequency based on maximum allowed distortion. Experimental results with various band-limited signals reveal a very good agreement between the theoretical results and the experiments.","palabras_clave":"PWM modulation|dead time|inverter|distortion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39634,"idioma_id":4,"titulo":"Simple Real-Time Digital PWM Implementation for class-D Amplifiers With Distortion-free Baseband","resumen":"A real-time, digital algorithm for pulse width modulation (PWM) with distortion-free baseband is developed in this paper. The algorithm not only eliminates the intrinsic baseband distortion of digital PWM but also avoids the appearance of side-band components of the carrier in the baseband even for low switching frequencies. Previous attempts to implement digital PWM with these spectral properties required several processors due to their complexity; the proposed algorithm uses only several FIR filters and a few multiplications and additions and therefore is implemented in real time on a standard DSP. The performance of the algorithm is compared with that of uniform, double-edge PWM modulator via experimental measurements for several bandlimited modulating signals.","palabras_clave":"digital PWM|real-time|low distortion|amplifier"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39635,"idioma_id":4,"titulo":"Virulence Variation among Epidemic and Non-Epidemic Strains of St. Louis Encephalitis Virus Circulating in Argentina","resumen":"Saint Louis encephalitis virus caused an outbreak of febrile illness and encephalitis cases in Córdoba, Argentina,in 2005. During this outbreak, the strain CbaAr-4005 was isolated from Culex quinquefasciatus mosquitoes. We hypothesised that this epidemic variant would be more virulent in a mouse model than two other non-epidemic strains (78V-6507 and CorAn-9275) isolated under different epidemiological conditions. To test this hypothesis, we performed a biological characterisation in a murine model, including mortality, morbidity and infection percentages and lethal infection indices using the three strains. Mice were separated into age groups (7, 10 and 21-day-old mice) and analysed after infection. The strain CbaAr-4005 was the most infective and lethal of the three variants, whereas the other two strains exhibited a decreasing mortality percentage with increasing animal age. The strain CbaAr-4005 produced the highest morbidity percentages and no significant differences among age groups were observed. The epidemic strain caused signs of illness in all inoculated animals and showed narrower ranges from the onset of symptoms than the other strains. CbaAr-4005 was the most virulent for Swiss albino mice. Our results highlight the importance of performing biological characterisations of arbovirus strains likely to be responsible for emerging or reemerging human diseases.","palabras_clave":"ARBOVIRUS|FLAVIVIRUS|ST LOUIS ENCEPHALITIS VIRUS|VIRULENCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39636,"idioma_id":4,"titulo":"A Toxocara cati eggs concentration method from cats faeces, for experimental  and diagnostic purposes","resumen":"Toxocariosis is a zoonotic parasite infection worldwide distributed, now considered a neglected disease associated to poverty. For experimental infection in animals and to develop the diagnosis in humans it is necessary to obtain large number of Toxocara spp. larval eggs. Toxocara cati eggs recovered percentage from faeces of infected cats was determined employing a novel egg concentration method. The McMaster egg counting technique and the concentration method were applied on 20 positive cats? sample faeces obtained from naturally infected cats. The mean percentage of eggs recovered by the concentration method was 24.37% higher than the count obtained by McMaster egg counting technique. The main advantage of this method is that it can be obtained a small final volume with a high number of recovered eggs and a good quality inoculum for experimental and diagnostic purposes.","palabras_clave":"TOXOCARA|CATI|FAECES|EGGS|DIAGNOSTIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39637,"idioma_id":4,"titulo":"Linear algebra based controller design applied to a bench-scale oenological alcoholic fermentation","resumen":"This work presents a controller design for a non-isothermal alcoholic fermentation to produce wines in a bench-scale bioreactor. The main controller objective is that the system tracks an optimal operation trajectory to produce wines with constant quality. This trajectory is previously determined for the biomass and for the CO2 produced by the fermentation. To meet the goal, the process is approximated using numerical methods, and then, the problem is posed like solving a system of linear equations. The necessary conditions for the system of linear equations has exact solution are analyzed. Afterwards the control action is obtained by solving the system of linear equations. The methodology success is shown using experimental results.","palabras_clave":"DIFFERENCE EQUATIONS|NON-ISOTHERMAL OPERATION|OENOLOGICAL ALCOHOLIC FERMENTATION|YEASTS GROWTH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39638,"idioma_id":4,"titulo":"Cassava (Manihot esculenta) starch films reinforced with natural fibrous filler","resumen":"tThe remaining fibrous residue of cassava starch extraction was characterized and used as film fillerin order to obtain an enhanced fully biodegradable starch-based composite. Film-forming gelatinizedcassava starch suspensions increased significantly their apparent viscosity and storage modulus withfiller addition, although no segregation of filler particles was observed. Homogenous films were obtainedfrom 3% w\/w cassava starch film-forming suspensions including glycerol as plasticizer and the remainingfibrous residue. Plasticizer concentration was optimized in reinforced starch films. SEM micrographs evi-denced that the filler was structurally incorporated in the matrix, although concentrations of 3% ledto more heterogeneous surfaces because of the presence of large size filler particles. Reinforced filmsexhibited UV-barrier capacity and adequate water vapor barrier properties (14.6 ± 0.7 10&#8722;11g\/m s Pa)and tensile strength (18.01 ± 0.19 MPa) when 25% w\/w glycerol was added as plasticizer. Filler addi-tion reinforced the starch matrix increasing its mechanical resistance: 1.5% residue content increasedover 900% the films elastic modulus. Furthermore, the obtained eco-compatible materials could be heatsealed, which indicates their suitability for packaging development. In conclusion, an integral approachto cassava roots use has been proposed, expanding its scope and providing added value to the remainingresidue of starch extraction.","palabras_clave":"Eco-compatible materials|Cassava starch films|Natural fillers|Mechanical properties"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39639,"idioma_id":4,"titulo":"Thermo-compression of biodegradable thermoplastic corn starch films containing chitin and chitosan","resumen":"Films based on thermoplastic corn starch (TPS) and chitosan\/chitin were obtained by melt-mixing and thermo-compression. Chitosan and chitin incorporation to TPS matrix induced some structural modifications due mainly to the interactions between starch hydroxyl and chitosan\/chitin amino groups. Crystallinity degree of TPS films was increased with biopolymers incorporation. Enthalpy melting values for TPS chitosan\/chitin films resulted lower than those corresponding to TPS control ones. Films had homogeneous and smooth surfaces, without pores and cracks and no glycerol migration was evidenced by Scanning Electronic Microscopy. Films fracture surfaces were uniform without the presence of unmelting starch granules neither chitosan\/chitin agglomerates. Films with chitosan\/chitin presented higher color, UV absorption capacity and opacity than TPS films. Addition of 10 g chitosan or chitin\/100 g starch decreased 35 and 56% water vapor permeability, respectively. Biopolymers addition to TPS increased tensile strength and elastic modulus, and decreased elongation at break. Starch and glycerol rich domains where evidenced in TPS matrixes by Dynamic Mechanical Analysis. Finally, TPS\/ chitosan films reduced Staphylococcus aureus and Escherichia coli growth in the contact zone.","palabras_clave":"Thermoplastic corn starch films with chitosan and chitin  |Thermo-compression|Structural characterization Barrier and mechanical properties| Antimicrobial capacity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39640,"idioma_id":4,"titulo":"EXPERIMENTAL INFECTION WITH Toxocara cati IN PIGS: MIGRATORY PATTERN AND  PATHOLOGICAL RESPONSE IN EARLY PHASE","resumen":"Experimental inoculations of approximately 100,000 infective Toxocara cati larval eggs were done in twelve pigs. The T. cati eggs   used for inoculation were collected from cat?s feces. Another group of three pigs served as an uninfected control. Groups of infected   pigs were euthanized at seven, 14, 21, and 28 days post-inoculation (dpi). Tissue samples were taken for digestion and histopathology   changes in early phase. The number of larvae recovered from the lungs peaked at seven and 14 dpi and were also present at 21, and   28 dpi. Larvae of T. cati were present in the lymph nodes of the small and large intestine at seven, 14, and 28 dpi and at seven, 14, 21,   and 28 dpi respectively. In other studied tissues, no larvae or less than one larva per gram was detected. The pathological response   observed in the liver and lungs at seven and 14 dpi, showed white spots on the liver surface and areas of consolidation were observed   in the lungs. The lungs showed an inflammatory reaction with larvae in center at 28 dpi. In the liver we observed periportal and   perilobular hepatitis. The lymph nodes of the intestines displayed eosinophil lymphadenitis with reactive centers containing parasitic   forms in some of them. The granulomatous reaction was not observed in any tissues. The role of the other examined tissues had less   significance. The relevance of this parasite as an etiological agent that leads to disease in paratenic hosts is evident.","palabras_clave":"Animal model |Larval recovery|Toxocara cati|Infected pig"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39641,"idioma_id":5,"titulo":"Las actividades laborales y extraescolares de jóvenes de la escuela secundaria en Argentina de principios de siglo veintiuno.","resumen":"El objetivo general del presente artículo es brindar evidencia de las transiciones entre la educación y el empleo de un segmento particular de la juventud en Argentina: los egresados de la educación secundaria. El análisis se realiza en base a la información producida en el marco del Proyecto La inserción ocupacional de los egresados de la escuela media: 10 años después, un estudio replicativo de un proyecto anterior desarrollado en 1999. La información en análisis corresponde a períodos caracterizados por situaciones económico ? sociales divergentes: el primer proyecto da evidencia de los procesos de inserción ocupacional durante la crisis de principios de 2000 y el segundo proyecto da cuenta de estos mismos procesos en un período de crecimiento económico y redistribución del ingreso de principios de 2010. Los resultados se presentan de manera comparativa, con la finalidad de aportar al debate sobre las transiciones juveniles en distintos contextos y estrategias económicas.","palabras_clave":"Jóvenes |Educación|Trabajo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39642,"idioma_id":4,"titulo":"Design method for a Historical Data Warehouse, explicit valid time in multidimensional models","resumen":"We present a new storage structure that contains the explicit valid time called Historical DW. This proposalcombines a Historical Data Base and a DW in one integrated model. The objective of this model is to solve the temporal limitations of the traditional multidimensional structures. Although the Temporal DW considers, besides the temporal dimension, other aspects related to time, this model only takes into account the changes that occur in the DW schema, both in dimensions and in hierarchies. Therefore, consideringthe need for registering values that allow to evaluate trends, variations, maximum and minimum values,a problem to be solved is how to shape the values of entities, attributes or relationships that may varyin time, in the design of the structure. The fact that the needed data was stored is already known, but the temporal search mechanisms would be complex. The Historical DW design is framed in the MDD approach, a strategy that allows, through successive automatic transformations, to obtain one of the implementations of the model in a Relational Data Base Management System (RDBMS).","palabras_clave":"datawarehouse|model driven development|design method"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39643,"idioma_id":4,"titulo":"A Model-Driven Approach to Constructing Robotic Systems","resumen":"Most robotic systems tend to becomplex to maintain and reuse because existing frameworks are based mainly oncode-driven approaches. This means the software development process is reducedto the implementation of systems using specific programming languages. Duringthe constant evolution, the systems grow in size and in complexity. Even whenthese approaches address the needs of robotic focused markets, currently usedmethodologies and toolsets fail to cope with the needs of such complex softwaredevelopment process. The general objective of our work is the definition of amethodological framework supported by a set of tools to deal with therequirements of the robotic software development process. A major challenge isto make the step from code-driven to model-driven in the development of roboticsoftware systems. Separating robotics knowledge from short-cycledimplementation technologies is essential to foster reuse and maintenance ","palabras_clave":"robotic system|modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39644,"idioma_id":4,"titulo":"Detecting students' perception style by using games","resumen":"Knowing students' learning styles allows us to improve their experience in an educational environment. Particularly, the perception style is one of the most important dimensions of the learning styles since it describes the way students perceive the world as well as the kind of learning content they prefer. Several approaches to detect students' perception style according to Felder's model have been proposed. However, these approaches exhibit several limitations that make their implementation difficult. Thus, we propose a novel approach to detect the perception style of a student by analyzing his\/her interaction with games, namely puzzle games. To carry out this detection, we track how students play a puzzle game and extract information about this interaction. Then, we train a Naive Bayes Classifier to infer the students' perception style by using the information extracted. We have evaluated our proposed approach with 47 Computer Engineering students. Experimental results showed that the perception style was successfully predicted through the use of games, with an accuracy of 85%. Finally, we conclude that games are a promising environment where the students' perception style can be detected. © 2013 Elsevier Ltd. All rights reserved.","palabras_clave":"Digital games|Learning styles|Naive Bayes classifier|Perception style"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39645,"idioma_id":4,"titulo":"MICROBIALITES IN A HIGH-ALTITUDE ANDEAN LAKE: MULTIPLE CONTROLS IN CARBONATE PRECIPITATION AND LAMINA ACCRETION","resumen":"ABSTRACT: Microbialites comprise the mineralized record of early life on Earth and preserve a spectrum of fabrics that reflectcomplex physical, chemical, and biological interactions. The relatively rarity of microbialites in modern environments, however,challenges our interpretation of ancient structures. Here we report the occurrence of microbial mats, mineral precipitates, andoncoids in the Laguna Negra, a high-altitude hypersaline Andean lake in Catamarca Province, Argentina. Laguna Negra is aCa-Na-Cl brine where abundant carbonate precipitation takes place. Extreme environmental conditions, including high UVradiation, elevated salinity, and temperature extremes, restrict multicellular life so that mineralization reflects a combination oflocal hydrologic conditions, lake geochemistry, and microbial activity. The resulting carbonates consist of micritic laminae,botryoidal cement fans, and isopachous cement laminae that are strikingly similar to those observed in Proterozoicstromatolites, providing insight into mechanisms of mineralization. Here, increased saturation with respect to carbonateminerals reflects mixing of spring-fed inlets and lake waters, favoring microbialite formation and preservation. This highlightsthe importance of hydrological mixing zones in microbialite formation and as taphonomic windows to record microbial activity.Recent discoveries of minerals related to evaporating playa-lake systems on Mars further highlights the potential of LagunaNegra to provide critical insight into biosignature preservation in both terrestrial and extraterrestrial settings.","palabras_clave":"microbialites|carbonate sedimentology|Geobiology|Puna"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39646,"idioma_id":4,"titulo":"Brackish to freshwater dinoflagellate cyst assemblages from the La Colonia Formation (Paleocene), northeastern Patagonia, Argentina","resumen":"A palynological analysis of the section of La Colonia Formation exposed at Estancia San Miguel yielded conspicuous assemblagesof organic-walled dinoflagellate cysts (dinocysts) and green algae. The monotypic palaeoperidinioid dinocyst assemblage of ?Ginginodiniumsp. in the basal beds of this section indicates low-salinity water conditions in a restricted shallow marine paleoenvironment. The green-algaedominatedassemblages together with specimens of ?Morkallacysta spp., Dinocysts type P and ?Vesperopsis sp. recorded in the middle andupper part of the San Miguel section indicate brackish to freshwater and freshwater depositional conditions, respectively. The changes in thecomposition of the palynological assemblages, in agreement with the analysis of the sedimentary facies, reflect a salinity-drop in the waterbodies and a progressive upward-shallowing trend. The occurrence of specimens of the neritic open marine Cribroperidinium spp., Apteodiniumsp., Circulodinium sp. and Areoligera sp. cf. A. circumsenonensis Fensome et al. is here considered as reflecting contemporaneous transportedmaterial from the adjacent shelf. The marine part of the La Colonia Formation is associated to Late Cretaceous and Paleocene ages.Nevertheless, palynomorphs together with a stratigraphical criterion suggest an age non older than Paleocene for the deposits of the unit atthe San Miguel section.","palabras_clave":"Green algae|Paleosalinity|Paleocene|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39647,"idioma_id":4,"titulo":"Holocene ochreous lacustrine sediments within the Famatina belt, NW Argentina: A natural case for fossil damming of an acid drainage system.","resumen":"A 44 m-thick lacustrine succession of silty-clay banded ochres and subordinated sandstones, and conglomerates(known as the Corral Amarillo Formation) is superbly exposed within the Famatina Belt(Central Andes of Argentina) after deep entrenchment by the present-day Amarillo river due to strongrecent uplifting and consequent relative drop in base level. The unusual ochreous-rich succession wasproduced by natural damming (3.48e3.54 14C kyr BP) of an acid drainage system linked to the alterationcap of polymetallic deposits. Facies of silty-clay ochre (wet season) and banded ochre (dry season) fromthe paleolacustrine setting are composed of jarosite þ goethite and goethite respectively. Geochemically,these layers record high concentrations of Fe2O3 (25e55 wt. %) and trace elements (Cu, Zn, Co, As, andMo with mean concentrations of 2759; 2467; 109; 375 and 116 ppm, respectively). Their origin is inferredfrom a comparative analysis with the present-day Amarillo river, which has a pH of w3, (SO4)2 concentrationsof w5000 mg\/l, and jarosite as the dominant phase, in the upper catchments. Watersdownstream have pH values of 3e4.5, (SO4)2 concentrations of w3000e480 mg\/l, and schwertmanniteas the dominant phase. Thus goethite in the paleolake facies is likely related to schwertmannite transformationby an aging process, whereas jarosite is probably transported from the river but could also beassociated with post-depositional formation regulated by variations in grain size and the pore fluidchemistry. The Corral Amarillo Formation offers a Natural model, which may be employed to infer theeffect on nature of acid drainage of mineralized areas.","palabras_clave":"Acid rock drainage|Paleolake deposits|Jarosite|Quaternary"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39648,"idioma_id":4,"titulo":"First fossil of Discocephalinae (Insecta: Heteroptera): a new genus from the Eocene of Patagonia, Argentina","resumen":"          A new genus and species  of Discocephalini, Acanthocephalonotum martinsnetoi gen. n. et sp. n. is  described from Río Pichileufú, middle Eocene of Patagonia, Argentina. The new  species is the first fossil representative of the Discocephalinae. This taxon  is extant in equatorial to subtropical America, and some species reach warm temperate latitudes. The new genus is distinguished from the other genera of  Discocephalini by the combination of these characters: interocular width  greater than head length; head massive and quadrangular with the anterior  margin almost straight; juga touching each other; labrum thick and curved; triangular  ante-ocular process extending beyond the eye;  broad spine-like antero-lateral process of the pronotum; pronotum explanate and  bean shaped; scutellum triangular with a circular tongue reaching the  anterior side of abdominal segment 7; and wings well  developed with membrane just surpassing end of abdomen.  ","palabras_clave":"Acanthocephalonotum gen. n.|Heteroptera,|Discocephalini"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39649,"idioma_id":4,"titulo":"Synthesis and characterization of Cu core Pt-Ru shell nanoparticles for the electro-oxidation of alcohols","resumen":"Cu@Pt-Ru coreeshell supported electrocatalysts have been synthesized by a two-stepprocess via a galvanic displacement reaction. XRD diffraction and EDX analysis, and cyclicvoltammetry measurements revealed the presence of nanoparticles composed by a CurichPteCu core surrounded by a Pt-rich PteRu shell. Cyclic voltammetry and chronoamperometricmeasurements showed that as-synthesized coreeshell materials exhibitsuperior catalytic activity towards methanol and ethanol electro-oxidation compared to acommercial PteRu\/C catalyst with higher Pt loading. This behavior can be associated withthe lattice mismatch between the Pt-rich shell and the Cu rich core, which in turn produceslattice-strain, surface ligand effects and a large amount of surface defect sites. In addition,the coreeshell electrodes displayed a better catalytic activity and lower onset potentials forethanol oxidation than for methanol oxidation.","palabras_clave":"Core-shell nanoparticles|Carbon supported electrocatalysts|Methanol and ethanol electro-oxidation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39650,"idioma_id":4,"titulo":"Azospirillum brasilense mitigates water stress imposed by a vascular disease by increasing xylem vessel area and stem hydraulic conductivity in tomato","resumen":"Water stress, with its negative consequences on plant growth and survival, can be mitigated by Azospirillum brasilense inoculation. In tomato, A. brasilense delays wilting caused by a vascular pathogen, Clavibacter michiganensis subsp. michiganensis, by yet unknown mechanisms. We studied morphological, anatomical and physiological changes induced by A. brasilense in tomato that relate to water stress tolerance, which could explain the deferral in symptom expression. For this purpose, tomato seeds were treated or not with A. brasilense BNM65, and 5 weeks later plants were challenged with C. michiganensis subsp. michiganensis or mock inoculated with water. There was a large growth promotion associated to Azospirillum: treated plants had higher total biomass and leaf area. In relation to water stress tolerance, Azospirillum treated plants had larger xylem vessel area, higher stem specific hydraulic conductivity, thicker stems, and lower shoot\/root dry matter and specific leaf area. These changes were opposite to those induced by C. michiganensis subsp. michiganensis. We conclude that A. brasilense favoured a better adjustment of plant-water relations by several mechanisms, and thus, transitorily alleviated symptoms expression of a vascular disease.","palabras_clave":"CLAVIBACTER MICHIGANENSIS SUBSP. MICHIGANENSIS|BACTERIAL CANKER|SOLANUM LYCOPERSICUM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39651,"idioma_id":4,"titulo":"A conceptual model and technological support for organizational knowledge management","resumen":"Knowledge Management (KM) models proposed in the literature do not take into account all necessary aspects for effective knowledge management. First, to address this issue, this paper presents a set of requirements that any KM model or initiative should take into account to cover all aspects implied in knowing processes. These requirements were identified through a critical and evolutionary analysis of KM. Second; the paper presents a new distributed KM Conceptual Model whose building blocks are the knowledge activities involved in knowing processes. These activities are: knowledge creation, knowledge sharing, and knowledge representation and retrieval. This model provides a holistic view of KM whose purpose is helping managers understand the scope of this initiative, and supplying a guide for research and implementation in organizations. In this sense, the model presents KM as a highly social rather than technological process. Third; the paper briefly describes an architecture to provide a technological support for knowledge representation and retrieval activities of the proposed KM Conceptual Model. This architecture allows implementing a distributed organizational memory that helps to represent the knowledge context through an ontological model, providing a local perspective of each knowledge domain within the organization. Strategies for knowledge annotation, knowledge retrieval, and ontology evolution are briefly described and results of preliminary performance analysis are shown. Finally; based on the available literature, a comparative analysis of different KM models shows their adequacy for previously presented requirements.","palabras_clave":"KNOWLEDGE MANAGEMENT|KNOWLEDGE MANAGEMENT MODEL|DISTRIBUTED ORGANIZATIONAL MEMORY|SEMANTIC INFORMATION RETRIEVAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39652,"idioma_id":4,"titulo":"Environmental factors associated with heterotrophic nitrogen-fixing bacteria in water, sediment  and riparian soil of Suquía River","resumen":"In this study we investigated the environmental factors associated with biological nitrogen (N) fixation(BNF) in water, sediments, and riparian soil along a polluted river (Suquía River of Córdoba, Argentina).Here, we screened heterotrophic nitrogen-fixing bacteria and assessed the magnitude of BNF at different sites of Suquía River. To this aim, samples of the three habitats (riparian soil, water, and sediment) were collected from five polluted sites and one reference site during low and high flow water periods. In all samples the abundance of N-fixing bacteria was evaluated in solid nitrogen-free medium and the biological N fixation was measured by nitrogenase (Nase) enzyme activity using the acetylene reduction method. To identify the heterotrophic N-fixing taxa DNA of nine cultures isolated from sites with different Nase enzyme activity was extracted and the 16S rRNA gene was amplified and sequenced. In addition, the ammonia and organic carbon (C) content in all samples, the dissolved O2concentration in water, and the water content in riparian soil were measured. The N-fixing bacteria were detected in all study sites and habitats. The abundance of them correlated significantly with organic C content in sediment, and with water and organic C contents in riparian soil, whereas in water a negative correlation with dissolved O2was observed. In addition, the water and sediment Nase enzyme activity varied among sites during low flow period presenting significant correlation with ammonia and organic C contents in sediment. The identified taxonomic groups in the Suquía River are related to Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, and Actinobacteria although the N-fixing capacity of them was not established. Altogether these findings demonstrate that BNF occurs in all habitats of Suquía River, being in sediments influenced mainly by the higher organic C present in the most polluted sites, while in riparian soil the organic C and water contents were the major abiotic factors that control the abundance of N-fixing bacteria. In Suquía River water the density of N-fixing bacteria were associated with low dissolved O2concentration. These data suggest that the BNF in Suquía River is a complex process that depends on numerous environmental factors that act together.","palabras_clave":"BIOLOGICAL NITROGEN FIXATION|LOTIC ECOSYSTEMS|NITROGENASE ENZIME ACTIVITY|ORGANIC CARBON"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39653,"idioma_id":4,"titulo":"Homeostasis and Secretion of  calcium in the oviductal mucosa of toad Rhinella arenarum","resumen":"The presence of a calcium pump, calbindin D-28KD and calmodulin in the secretory cells (SC) of the oviductal pars convoluta (PC) of Rhinella arenarum was established for the first time in amphibians using immunohistochemical techniques. Marked variations were observed in the localization and degree of expression of these proteins according to the duct segment and the period of the sexual cycle analyzed. During the preovulatory and ovulatory periods the calcium pump colocalized with calbindin D-28KD can be seen mainly in the apical border of the SC, which are located in the first zones of PC and synthesize and secrete the components of the inner jelly coat layers. These envelopes, which surround the oocytes, contain the molecules indispensable for fertilization, probably inducing the sperm acrosome reaction (AR). Our results suggest that calmodulin, colocalized with the calcium pump at the SC cytoplasmic level, would be involved in the active transport of the cation inside the secretory granules, maintaining adequate levels of intracellular Ca2+.During the postreproductive period, a calcium pump colocalized with calbindin D-28KD appears for the first time in the cycle in the basal zones of the SC. This system would be related to thereplenishing of intracellular Ca2+ stores.","palabras_clave":"AMPHIBIAN|CALCIUM|FERTILIZATION|REPRODUCTIVE CYCLE|TRANSCELLULAR TRANSPORT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39654,"idioma_id":4,"titulo":"Detection of Trypanosoma evansi infection in wild capybaras from Argentina using smear microscopy and real-time PCR assays","resumen":"Trypanosoma evansi is a flagellated protozoan that parasitizes a wide variety of mammals, occasionally including humans. In South America, it infects horses, cattle, buffaloes, dogs and wild mammals, causing a disease known as ?Mal de Caderas?, which results in important economic losses due to a wide range of pathological expressions. Argentina represents the southern limit of its distribution.    The capybara (Hydrochoerus hydrochaeris) is a large rodent found in tropical to temperate freshwater wetlands of South America. As capybaras infected with T. evansi present no clinical signs of disease, withstanding high parasitaemia, this species was proposed as a reservoir host.    In this study we investigated the prevalence and parasitaemic intensity of T. evansi in samples obtained from 60 free-ranging capybaras of Esteros del Iberá (Corrientes province, northeastern Argentina) using smear microscopy and real-time PCR assays. All the cases of capybaras infected with T. evansi were found during one of the years studied, with no evidence of seasonality. The overall infection prevalence was 10%, but between years it ranged from 0% to 17% (in 2011). This is the &#64257;rst confirmation of T. evansi infection in Argentina by molecular biology techniques. Our results showed no differences between the methods used to detect the presence of T. evansi in capybaras, which indicates that simple methods like microscopy can generate important data on the ecoepidemiology of this parasite. Both techniques used in this study represent a viable tool for ecoepidemiological studies, and can be used to produce good estimates of prevalence and parasitaemic level of the infection, which inform for the implementation of strategies for the control of the disease.","palabras_clave":"TRYPANOSOMA EVANSI|MAL DE CADERAS|SURRA|HYDROCHOERUS HYDROCHAERIS|CAPYBARA|SMEAR MICROSCOPY|REAL TIME PCR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39655,"idioma_id":4,"titulo":"Stability of the resistance to the thiosemicarbazone derived from 5,6-dimethoxy-1-indanone, a non-nucleoside polymerase inhibitor of bovine viral diarrhea virus","resumen":"            Abstract                        Bovine viral   diarrhea virus (BVDV) is the prototype Pestivirus. BVDV infection is   distributed worldwide and causes serious problems for the livestock   industry. The thiosemicarbazone of 5,6-dimethoxy-1-indanone (TSC) is a   non-nucleoside polymerase inhibitor (NNI) of BVDV. All TSC-resistant   BVDV variants (BVDV-TSCr T1-5) present an N264D mutation in the NS5B   gene (RdRp) whereas the variant BVDV-TSCr T1 also presents an NS5B A392E   mutation. In the present study, we carried out twenty passages of   BVDV-TSCr T1-5 in MDBK cells in the absence of TSC to evaluate the   stability of the resistance. The viral populations obtained (BVDV R1-5)   remained resistant to the antiviral compound and conserved the mutations   in NS5B associated with this phenotype. Along the passages, BVDV R2, R3   and R5 presented a delay in the production of cytopathic effect that   correlated with a decrease in cell apoptosis and intracellular   accumulation of viral RNA. The complete genome sequences that encode for   NS2 to NS5B, Npro and Erns were analyzed. Additional mutations were   detected in the NS5B of BVDV R1, R3 and R4. In both BVDV R2 and R3, most   of the mutations found were localized in NS5A, whereas in BVDV R5, the   only mutation fixed was NS5A V177A. These results suggest that mutations   in NS5A could alter BVDV cytopathogenicity. In conclusion, the   stability of the resistance to TSC may be due to the fixation of   different compensatory mutations in each BVDV-TSCr. During their   replication in a TSC-free medium, some virus populations presented a   kind of interaction with the host cell that resembled a persistent   infection: decreased cytopathogenicity and viral genome synthesis. This   is the first report on the stability of antiviral resistance and on the   evolution of NNI-resistant BVDV variants. The results obtained for   BVDV-TSCr could also be applied for other NNIs. ","palabras_clave":"bovine viral diarrhea virus.|antiviral|resistance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39656,"idioma_id":4,"titulo":"Genetic and evolutionary characterization of Venezuelan equine encephalitis virus isolates from Argentina","resumen":"Venezuelan equine encephalitis viruses (VEEV) are emerging pathogens of medical and veterinary importancecirculating in America. Argentina is a country free from epizootic VEEV activity, with circulation ofenzootic strains belonging to Rio Negro virus (RNV; VEEV subtype VI) and Pixuna virus (PIXV, VEEV subtypeIV). In this work, we aim to report the sequencing and phylogenetic analyses of all Argentinean VEEviruses, including 7 strains previously isolated from mosquitoes in 1980, 5 sequences obtained fromrodents in 1991 and 11 sequences amplified from mosquitoes between 2003 and 2005. Two genomicregions, corresponding to the non-structural protein 4 (nsP4) and the protein E3\/E2 (PE2) genes wereanalyzed, but only 8 samples could be amplified in the last one (longer and more variable fragment of702 bp). For both genomic fragments, phylogenetic trees showed the absence of lineages within RNVgroup, and a close genetic relationship between Argentinean strains and the prototype strain BeAr35645for PIXV clade. The analysis of nsP4 gene opens the possibility to propose a possible geographic clusteringof strains within PIXV group (Argentina and Brazil). Coalescent analysis performed on RNV sequencessuggested a common ancestor of 58.3 years (with a 95% highest posterior density [HPD] interval of16.4?345.7) prior to 1991 and inferred a substitution rate of 9.8  105 substitutions\/site\/year, slightlylower than other enzootic VEE viruses. These results provide, for the first time, information about geneticfeatures and variability of all VEEVs detected in Argentina, creating a database that will be useful forfuture detections in our country. This is particularly important for RNV, which has indigenous circulation.","palabras_clave":"Venezuelan equine encephalitis virus|genetic|evolution|epidemiology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39657,"idioma_id":4,"titulo":"Flavoprotein monooxygenases for oxidative biocatalysis: recombinant expression in microbial hosts and applications","resumen":"External flavoprotein monooxygenases comprise a group of flavin-dependent oxidoreductases that catalyze the insertion of one atom of molecular oxygen into an organic substrate and the second atom is reduced to water. These enzymes are involved in a great number of metabolic pathways both in prokaryotes and eukaryotes. Flavoprotein monooxygenases have attracted the attention of researchers for several decades and the advent of recombinant DNA technology caused a great progress in the field. These enzymes are subjected to detailed biochemical and structural characterization and some of them are also regarded as appealing oxidative biocatalysts for the production of fine chemicals and valuable intermediates toward active pharmaceutical ingredients due to their high chemo-, stereo- and regioselectivity. Here, we review the most representative reactions catalyzed both in vivo and in vitro by prototype flavoprotein monooxygenases, highlighting the strategies employed to produce them recombinantly, to enhance the yield of soluble proteins, and to improve cofactor regeneration in order to obtain versatile biocatalysts. Although we describe the most outstanding features of flavoprotein monooxygenases, we mainly focus on enzymes that were cloned, expressed and used for biocatalysis during the last years.","palabras_clave":"FLAVOPROTEIN MONOOXYGENASE|BAEYERVILLIGER OXIDATION|BIOOXIDATIONS|BIOCATALYSIS |SULFOXIDATION  |EPOXIDATION  |HYDROXYLATION| RECOMBINANT BIOCATALYST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39658,"idioma_id":4,"titulo":"MIDDLE TO LATE HOLOCENE RELATIVE SEA LEVEL CHANGES AT PUERTO DESEADO (PATAGONIA, ARGENTINA)","resumen":"Stratigraphic, morphologic and radiocarbon data from Puerto Deseado coastal area (Santa Cruz  Province, Argentina) indicate that Holocene coast formed in response to the discontinuous  aggradation of coarse gravely beach since ca. 6300 cal BP related to a progressive falling of relative  sea level. Beach ridge crests crudely approximate the sea level showing at least 3 steps of  aggradation and relative sea level lowering. Two inactive abrasive notches at ca. 6 and 1.8 m a.h.T.  (above high tide) have recorded this sea level trend suggesting two important phases of sea level  stationing. This allows to estimate a rate of relative sea level falling in the last ca. 3500 cal BP of  ca 1.8 mm\/a. Moreover, notches and morphological data indicate that the crest of the beach ridges  overestimated the sea level of ca. 2±0.5 m. This values seems a reasonable regional correction to be  applied to this sea level markers for producing comparable relative sea level curve for Atlantic  Patagonia coast.","palabras_clave":"RELATIVE SEA LEVEL|BEACH RIDGES|HOLOCENE|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39659,"idioma_id":4,"titulo":"Craniofacial variation, body size and ecological factors in aboriginal populations from Center Patagonia (2000-200 years BP)","resumen":"            Previous  studies have shown that ecological factors had a significant role in shaping  the patterns of craniofacial variation among South American populations. Here,  we evaluate whether temperature and diet contributed to facial diversification  in small geographic areas. Facial size and shape of 9 osteological simples from  central Patagonia (Argentina) were described using 2D landmarks and  semilandmarks. Data on mean annual temperature, diet composition (13C and 15N values) and femoral  head maximum breadth, used as a proxy of body mass, were obtained for each sample.  We then tested the association of body mass and the ecological variables with  facial morphology using spatial regression techniques and a model selection  approach. Akaike Information Criterion produced disparate results for both  components of facialmorphology. The best model for facial size included temperature  and body mass proxy, and accounted for more than 80% of variation in size.  Lower temperatures were related to larger facial sizes. Body mass was  negatively associated with facial size and showed no relationship with the  temperature. This suggests a relatively independent variation of cranial traits  and body mass at the spatial scale studied here. Facial shape was not  associated with the temperature or diet composition, contrasting with the  patterns observed at larger spatial scales. Our results point out that the  effect of climatic variables on cranial traits might be a source of  morphological differentiation not only at large scales but also in small  geographic areas, and that size and shape display a differential preservation  of environmental signals.  ","palabras_clave":"Variacion craneofacial|tamaño corporal|poblaciones humanas|escala local"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39660,"idioma_id":4,"titulo":"Evaluation of immune response, microbiota, and blood markers after probiotic bacteria administration in obese mice induced by a high-fat diet","resumen":"Objective: Obesity is associated to alterations in the intestinal microbiota and immunity. The aim of this study was to determine the effect of probiotic Lactobacillus casei CRL 431 administration on intestinal and humoral immune response, clinical parameters, and gut microbiota was evaluated using a high-fat diet to induce obesity in a mouse model. Methods: Adult mice received a conventional balanced diet or a high-fat diet supplemented with milk, milk fermented by Lactobacillus casei (FM), L. casei as suspension or water over 60 d. Histology of liver and small intestine (SI), immunoglobulin A-positive cells and macrophages in SI, phagocytic activity of spleen and peritoneal macrophages, and humoral immune response to ovalbumin were studied. Clinical parameters in serum and gut microbiota were also analyzed. Results: FM was the most effective supplement to decrease body weight and clinical parameters in serum. The histology of liver and SI was also improved in obese mice given FM. These animals increased the number of immunoglobulin A-positive cells and macrophages in SI. The gut microbiota showed that obese mice given probiotics increased Bacteroides and bifidobacteria. Administration of FM or L. casei as suspension enhanced the phagocytic activity of macrophages. The anti-ovalbumin specific immune response was not increased by any supplement assayed. Conclusion: Probiotic administration to obese hosts improved the gut microbiota and the mucosal immunity altered by obesity, down-regulated some biochemical parameters in blood associated with metabolic syndrome and decreased liver steatosis. These results demonstrate the potential use of probiotics in obese individuals to decrease the body weight and to improve the biochemical and immunologic parameters altered by obesity.","palabras_clave":"PROBIOTIC|FERMENTED MILK|OBESITY|HUMORAL IMMUNE RESPONSE|GUT IMMUNITY|GUT MICROBIOTA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39661,"idioma_id":4,"titulo":"Intentional Teaching Facilitates Young Children's Comprehension and Use of a Symbolic Object","resumen":"Children are exposed to symbolic objects that they have to learn to use very early in life. The aim of the present research was to examine whether we can intentionally teach young children the symbolic function of an object. We employed a search task in which children had to use a map to find a toy. Experiment 1 revealed that with no-instruction 3;10-year-old children were quite successful, 3;6-year-olds showed a divided performance, and 3;0-year-olds failed. With this baseline, Experiment 2 compared the performance of 3;0-year-olds in three different conditions: no-instruction, complete instruction (before the task begins), and teaching (complete instruction plus corrective feedback); only children in the teaching condition succeeded. However, children six months younger, 2;6-year-olds, failed despite teaching was provided (Study 3). This research shows that at some points in development instruction is not enough, intentional teaching in communicative contexts is the mechanism that boosts symbolic understanding in early childhood.","palabras_clave":"SYMBOLIC OBJECTS|INTENTIONAL TEACHING|CORRECTIVE FEEDBACK|CONTINGENT INFORMATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39662,"idioma_id":4,"titulo":"On-line flow injection solid phase extraction using oxidised carbon nanotubes as the substrate for cold vapour-atomic absorption determination of Hg(II) in different kinds of water","resumen":"A study was carried out to investigate the concentrations of Hg(II) in different categories of water samples at ng L&#8722;1 levels. The capabilities of oxidised carbon nanotubes (ox-CNTs) were studied to assess if this substrate serves as an efficient material for Hg(II) preconcentration using an on-line flow injection cold vapour-atomic absorption spectrometry (FI-CV-AAS) system. Carbon nanotubes are characterized by a marked tendency to aggregate, which negatively affects the retention of Hg whenever integrated in flow systems as a packed column. For this reason, the preconcentration was carried out in a microcolumn filled with a mixture of ox-CNTs and a low molecular weight polyethylene. The preparation of the microcolumn was studied in detail. Concerning column design, the best performance was achieved when packing the substrate in a microcolumn of 2.25 mm (i.d.) × 20 mm length. The effect of chemical and physical parameters including the pH of the solutions, the eluent type and the concentration was systematically examined. Mercury was retained at pH 5.0 and 15% (v\/v) HCl was the best alternative for Hg(II) elution. Under optimal conditions, the adsorption capacity of the substrate was found to be 3.2 mg g&#8722;1 reaching a preconcentration factor (PF) of 150. The high adsorption capacity of this substrate allowed reaching a detection limit (3&#963;) of 1.9 ng L&#8722;1, when using a sorbent column containing only 1.0 mg of ox-CNTs. The limit of quantification (10&#963;) resulted to be 6.3 ng L&#8722;1. Precision, expressed as relative standard deviation (RSD), turned out to be 1.6% at the 0.1 &#956;g L&#8722;1 level (n = 8). The system was evaluated for quantitative determination of Hg in river water, sea water and effluents.","palabras_clave":"WATER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39663,"idioma_id":4,"titulo":"Agricultural impact on soil organic carbon content: Testing the IPCC carbon accounting method for evaluations at county scale","resumen":"Soil  organic carbon (SOC) plays a vital role in determining soil quality  and health, but also SOC decrease contributes significantly to the  increase in atmospheric CO2 concentration. Countries need to quantify  their SOC stocks and flows in order to assess their greenhouse gas  emissions. To facilitate this, the Intergovernmental Panel on Climate  Change has developed a simple carbon accounting method to estimate  SOC stocks and flows in response to changes in land use. This method  proposes three tiers for SOC change estimation. The higher the tier  the greater the accuracy of the estimates, but also the complexity  and the need of information. We used the RothC model to derive SOC  change factors in order to develop a Tier 2 (T2) method. We applied  this T2 and Tier 1 (T1) methods to estimate SOC stocks and flows in  five sub regions of the Argentinean Pampa Region between 1900 and  2006. We evaluated T1 and T2 methods performances comparing their  estimates against empirical data, at sub region and county scales. At  both spatial scales, T1 method showed a poor performance and an  important improvement was achieved with T2 method, although its  performance varied among spatial scales. At sub region scale, T2  method estimates were very good (R2  = 0.85), but at county scale the fit was poor (R2  = 0.46). However, this poor fit may have been due, at least in part,  to the quality of the input and validation information of one of the  sub regions (Flooding Pampa) since its exclusion of the analysis led  to an increase of the R2  up to 0.73. Tier 2 was used to estimate the impact of land use change  on SOC. Sub regions with the highest estimated SOC losses were  Central Pampa, Southern Pampa ? Eastern and Rolling Pampa, with  35%, 28% and 26% average SOC losses, respectively. Given that several  conceptual limitations of T1 method were overcome with our simple T2  method, we conclude that T2 method is more realistic to conduct a  regional SOC inventory. Besides, our T2 method was developed without  using empirical information from field or laboratory studies about  SOC change and, therefore, countries that have not enough empirical  information available on SOC change associated to land use could  derive a similar T2 method.   ","palabras_clave":"Land use change|Soil carbon inventory|IPCC|Argentinean Pampean region|Tier 2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39664,"idioma_id":5,"titulo":"Estilos y estrategias de Aprendizaje en alumnos univeristarios","resumen":"El presente trabajo tiene como objetivo comparar estilos y estrategias de aprendizaje que poseen alumnos que cursan diferentes carreras universitarias. Participaron de la investigación alumnos de tercer año de la Universidad Católica Argentina sede Mendoza de las carreras de Psicopedagogía y Contador. A modo de hipótesis se planteó que los alumnos de tercer año que estudiaban la misma carrera tiene el mismo estilo de aprendizaje y aplican similares estrategias para abordar el estudio; y que se encontraban diferencias en estos aspectos entre los alumnos de las carreras mencionadas. Se exploraron los estilos de aprendizaje en ambas carreras, a través de la administración de los cuestionarios CHAEA (cuestionario Honey-Alonso de Estilos de aprendizaje, 1992) y las estrategias de aprendizaje a través de ACRA-A (versión abreviada de De La Fuente Arias y Justicia, 2003). Al analizar los resultados obtenidos se concluye que los alumnos que estudian la misma carrera poseen un estilo de aprendizaje similar, por lo que se encuentra predominancia de un estilo de aprendizaje sobre otro según el tipo de carrera. No siendo así con las estrategias de aprendizaje, ya que no se advierten diferencias notables en su aplicación por alumnos de ambas carreras.","palabras_clave":"ESTUDIANTES|ESTRATEGIAS|ESTILOS|APRENDIZAJE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39665,"idioma_id":4,"titulo":"POPULATION GENETIC STRUCTURE OF THE FRESHWATER ANOMURAN AEGLA URUGUAYANA SCHMITT, 1942 (DECAPODA, AEGLIDAE) IN THE CENTRAL REGION OF ARGENTINA","resumen":"Aeglidae is the only freshwater family in the infraorder Anomura. Aegla uruguayana Schmitt, 1942 is one of themost widely distributed species in southern South America and is found in different environments, which makes it an interesting object for population genetic studies. The main objective of this work was to analyse the genetic population structure of A. uruguayana along a sea distance gradient for four populations that were studied in the La Plata Basin with an 1100-km range in relation to an east-west transect. The populations studied were the Río Tercero Reservoir, the Setúbal Lagoon, the Doll Stream and the Urquiza Stream. Aeglid DNA was extracted using a commercial kit that was amplified with ISSR markers. Of the 10 primers tested, we selected four that showed the best resolution and reproducible results. Our studies revealed a He of 0.3479 ± 0.1383 (mean ± SD) and a global FST of 0.3583 (p<0.0001), demonstrating genetic differentiation among populations with low gene flow. The Urquiza Stream population showed a genetic structure clearly different from that of the other populations. However, the Río Tercero, Setúbal and Doll populations were well grouped with one effective connection among them. The geomorphologic history of the basin provides  evidence for the isolation hypothesis. These data demonstrate the importance of geoclimatic history in the study region and the importance of using complete population distribution data where the species live. These data permit us to interpret that different populations have independent histories that are delineated by the geomorphological events that occurred on earth.","palabras_clave":"POLYMORPHISM|ISSR|FRESHWATER ANOMURA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39666,"idioma_id":4,"titulo":"THE TAXONOMIC STATUS OF THE PLIOCENE CAPYBARAS (RODENTIA) PHUGATHERIUM AMEGHINO AND CHAPALMATHERIUM AMEGHINO","resumen":"Living capybaras are a unique group of rodents. They have ever-growing cheek teeth with a complicated occlusal morphology that  changes even after birth. Concerning fossil capybaras this morphological change, associated with increasing size, led to regard them as taxonomical  highly diverse, including small species with simple dental morphology, and large species with complicated cheek teeth, considered  as primitive and derived, respectively. Recently, it was proposed that the different morphs found in each locality actually represent individuals  of different ontogenetic stages of a population or successive populations, rather than a multiplicity of coeval species in different stages of evolution.  For the Pliocene, the richest locality for capybaras is Farola Monte Hermoso at the southern coast of Buenos Aires Province. This yielded  four nominal species of capybaras, three of them are a small morph (Phugatherium cataclisticum, ?Anchimysops villalobosi?, ?A. ultra?) and the  other a large one (?Chapalmatherium perturbidum?). In this paper we propose that they represent juveniles and adults of one species, P. cataclisticum.  In order to evaluate the phylogenetic position of Phugatherium within Cavioidea a cladistic analysis was performed modifying a  previously published combined matrix of morphology and DNA sequences. Phugatherium forms a monophyletic group and is the sister  group of modern capybaras. Within Phugatherium the most basal species is P. novum, whereas the type species P. cataclisticum is the sister  group of P. saavedrai.","palabras_clave":"RODENTIA|HYDROCHOERIDAE|TAXONOMY|PLIOCENE|SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39667,"idioma_id":4,"titulo":"Toxicity enhancement of Clostridium argentinense by non O1, non O139 Vibrio cholerae in co-culture","resumen":"      The growth  and botulinic toxin production of Clostridium  argentinense G 89 HT in co-culture with non O1, non O139 Vibrio cholerae &nbsp;&nbsp;were studied using three culture systems, operated  under different aeration conditions. Growth in homogeneous co-culture with  aerobic and anaerobic stage presented a dual-phase progression and 2000 LD50  of botulinum toxin was obtained. &nbsp;This  value represented an increase of 20 times compared with the other culture  systems studied and high levels of protease activity were achieved. &nbsp;The remarkable increase on the toxicity of C. argentinense G 89 HT was attributed  to activation of the toxin by non O1, non O139 Vibrio cholerae &nbsp;proteases. &nbsp;The heterogeneous co-culture obtained with a dialysis  membrane physically separating both bacteria, thereby eliminating the protease  activity, produced low levels of activity toxigenic.   ","palabras_clave":"Clostridium argentinense|Non O1, non O139 Vibrio cholerae|Co-culture|Toxin activation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39668,"idioma_id":4,"titulo":"Quantitative Micrograph, HPLC and FTIR profiles of Melissa officinalis and Nepeta cataria (Lamiaceae) from Argentina","resumen":"Melissa officinalis L., so called 'Melissa' or 'Toronjil', is a perennial aromatic herb, whose leaves are used in traditional medicine as a carminative, digestive and sedative, both in simple as in mixtures. Meanwhile, Nepeta cataria L., commonly called 'Cat mint' or 'Toronjil', with some similar properties, often replacing M. officinalis in the market, although their chemical composition is not completely matched, and contains an iridoid potentially toxic (nepetalactone). It is therefore necessary to establish diacritic parameters to differentiate these species, both at crude drug level, mixtures and extracts. Samples from various sources in Argentina were studied and documental specimens are preserved in the Herbarium UNSL. Anatomical sections were analyzed, and quantitative micrographic parameters were obtained, together with HPLC and FTIR spectra from methanolic and aqueous lyophilized extracts. Significant differences were detected in the prevailing smell foliage, morphology of leaves and inflorescences, trichomata type, palisade ratio, veinlet termination number, rosmarinic acid concentration (with distinctive HPLC profiles), and the CO\/CH relationships obtained by FTIR from the extracts, that together allow adequate differentiation of both drugs, even when they were ground or powdered. Quantitative Micrograph, HPLC and FTIR profiles of Melissa officinalis and Nepeta cataria (Lamiaceae) from Argentina (PDF Download Available). Available from: https:\/\/www.researchgate.net\/publication\/279804279_Quantitative_Micrograph_HPLC_and_FTIR_profiles_of_Melissa_officinalis_and_Nepeta_cataria_Lamiaceae_from_Argentina [accessed Feb 21 2018].","palabras_clave":"Melissa officinalis|Nepeta cataria|quantitative micrograph|HPLC, FTIR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39669,"idioma_id":5,"titulo":"Seguridad del paciente: Errores de medicación (EM) en fármacos utilizados para el tratamiento de patologías cardiovasculares notificados al Centro Regional de Farmacovigilancia de la UNNE- ANMAT (CRF-UNNE).","resumen":"Se presenta el análisis de los  reportes de errores de medicación cardiovascular presentados al CRF-UNNE desde 1995 a 2013.  Trabajo subsidiado por la SGCyT-UNNE","palabras_clave":"SEGURIDAD DEL PACIENTE|ERRORES DE MEDICACIÓN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39670,"idioma_id":5,"titulo":"Identificación de C-glicosilflavonas por HPLC y FTIR, en extractos acuoso y metanólico de Passiflora caerulea y P. foetida (Passifloraceae)","resumen":"Several species of Passiflora L. (Passifloraceae) are used in traditional medicine for the treatment of anxiety, insomnia, and other nervous disorders. Various C-glycosylflavones have been isolated from these species. In this study the presence of C-glycosylflavones in Passiflora caerulea L., and P. foetida L. was determined by HPLC, and FTIR was used in a comparative form, in order to contribute to the quality control as well as the identification and authentication of these compounds from crude drugs, aqueous extracts and methanolic extracts of these species, with which some herbal medicines are prepared. HPLC chromatograms of both, aqueous and methanolic extracts, showed characteristic peaks at retention time 12.10 min (vitexin), 17.94 min (isovitexin), 19.93 min (orientin), and 25.11 min (isoorientin) with characteristic UV spectra. P. caer¬ulea contained the four mentioned C-glycosylflavones, while P. foetida showed a lack of isoorientin in the aqueous extract, and contained only vitexin and isovitexin in the methanolic extract. Substantial qualitative differences in the ?fingerprint? region of the FTIR profile were found. P. foetida showed a band at 1250 cm 1 which was not detected in P. caerulea. The CO\/CH ratio in the aqueous extract was 3.87 in P. caerulea, while 1.58 in P. foetida. The CO\/CH ratio in the methanolic extract in P. caerulea was 17.09 and 15.40 in P. foetida. These spectral data helped to characterize both species during quality control of crude drugs and herbal medicines containing these plants in their formulationDiscover the world´s research Identificación de C-glicosilflavonas por HPLC y FTIR en extractos acuoso y metanólico de Passiflora caerulea y P. foetida (Passifloraceae) (PDF Download Available). Available from: https:\/\/www.researchgate.net\/publication\/282612833_Identificacion_de_C-glicosilflavonas_por_HPLC_y_FTIR_en_extractos_acuoso_y_metanolico_de_Passiflora_caerulea_y_P_foetida_Passifloraceae [accessed Feb 20 2018].","palabras_clave":"Passiflora caerulea|Passiflora foetida|HPLC|FTIR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39671,"idioma_id":4,"titulo":"{k}-packing Functions of Graphs","resumen":"Given a positive integer $k$ and a graph $G$,  a $k$-limited packing in $G$ (2010) is a subset $B$ of its vertex set such that each closed neighborhood has at most $k$ vertices of $B$. As a variation, we introduce the notion of a emph{${k}$-packing function} $f$ of $G$ which assigns a non-negative integer to the vertices of $G$ in such a way that the sum of $f(v)$ over each closedneighborhood is at most $k$.  For fiixed $k$, we prove that the problem of finding a ${k}$-packing function of maximum weight (${k$}PF) can be reduced linearly to the problem of finding a $k$-limited packing of maximum cardinality ($k$LP).  We present an $O(|V(G)|+|E(G)|)$ time algorithm to solve ${k$}PF on strongly chordal graphs. We also use monadic second-order logic to prove that both problems are linear time solvable for graphs with clique-width bounded by a constant.","palabras_clave":"PACKING FUNCTIONS|LINEAR REDUCTION|STRONGLY CHORDAL  GRAPHS|MONADIC SECOND ORDER LOGIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39672,"idioma_id":5,"titulo":"Dieta de Phytotoma rutila (Passeriformes: Cotingidae) en el desierto  del Monte central, Argentina","resumen":"Se determinó la composición botánica de la dieta del Cortarramas Phytotoma rutila en el desierto del Monte central, Argentina, mediante análisis microhistológico de las heces. En ambos sexos, la dieta estuvo compuesta por una importante proporción de frutos (26.8%) y hojas (35.6%) del arbusto Lycium tenuispinosum (Solanaceae) y hojas del árbol Prosopis fl exuosa (Fabaceae) (26.8%). P. rutila es una ave predominantemente folívora con un alto consumo de frutos durante el verano, cuando estos ítems son abundantes, lo que refl eja su comportamiento oportunista.","palabras_clave":"COMPORTAMIENTO|DIETA|OPORTUNISMO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39673,"idioma_id":4,"titulo":"Intravaginal placebo sponges affect negatively the conception rate in sheep","resumen":"Intravaginal sponges (IS) impregnated with progestagens are commonly used for oestrous synchronization in ewes. However, the use of IS is a predisposing factor for vaginal contamination that can affect negatively fertility. The objective of this work was to determine if the use of IS negatively affects the fertility. The experiment was conducted on a commercial farm (Uruguay), during March-May (mid-breeding season) with 575 mature Australian Merino ewes. Oestrous was recorded daily with vasectomized rams for 5 d in ewes that received a single dose of a PGF2alpha analogue. Two days after oestrous detection, females were randomly allocated to three groups: Group MAP (n&nbsp;=&nbsp;200) received an intravaginal polyurethane sponge impregnated with 60&nbsp;mg of medroxyprogesterone acetate (MAP) for 13 days. At the same time, sponges without MAP were inserted in 156 ewes (ISG Group), and remained in situ also for 13 days. Other 213 ewes (Group CG) remained as a control of the fertility of the spontaneous oestrus, without treatment. Ewes presenting oestrous were inseminated 12&nbsp;h later. Conception rates were determined by rectal ultrasound 30 days after oestrus. Conception rate of the CG group was greater than that of MAP and ISG groups (CG: 55.4% vs MAP: 41.5% and ISG: 34.6%; p&nbsp;=&nbsp;0.0002), without differences between the last two. We conclude that the IS is responsible itself for a significant reduction in conception rate in oestrous synchronization treatments in sheep.","palabras_clave":"ARTIFICIAL INSEMINATION|INTRAVAGINAL DEVICES|OESTROUS SYNCHRONIZATION|SHEEP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39674,"idioma_id":4,"titulo":"Melatonin therapy in patients with Alzheimer's disease","resumen":"Abstract: Alzheimer?s disease (AD) is a major health problem and a growing recognition exists that efforts to prevent it must be undertaken by both governmental and non-governmental organizations. In this context, the pineal product, melatonin, has a promising significance because of its chronobiotic\/cytoprotective properties potentially useful for a number of aspects of AD. One of the features of advancing age is the gradual decrease in circulating melatonin levels. A limited number of therapeutic trials have indicated that melatonin has a therapeutic value as a neuroprotective drug in the treatment of AD and minimal cognitive impairment (which may evolve to AD). Both in vitro and in vivo, melatonin prevented the neurodegeneration seen in experimental models of AD. For these effects to occur, doses of melatonin about two orders of magnitude higher than those required to affect sleep and circadian rhythmicity are needed. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects, which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50?100 mg\/day are urgently needed to assess its therapeutic validity in neurodegenerative disorders such as AD.","palabras_clave":"MELATONINA|ENFERMEDAD DE ALZHEIMER|NEURODEGENERACIÓN|RADICALES LIBRES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39675,"idioma_id":4,"titulo":"Prenatal lead exposure and relationship with maternal exposure determinants in a public maternity hospital of La Plata, Argentina","resumen":"Prenatal lead exposure is a health hazard that may cause cognitive development impairments and other adverse effects in children. We conducted a cross sectional study analyzing cord blood lead levels (CBLL) of newborns and their relationship with maternal determinants of lead exposure. Mothers answered a questionnaire about socio-demographic, lifestyle habits and environmental characteristics. We used Mann-Whitney's test to compare CBLL geometrical means (GM) corresponding to the presence or absence of each lead exposure determinant, and Chi square test to study the relationship between CBLL and maternal lead exposure determinants. A total of 159 newborns participated in the study. CBLL GM was 2.1 &#956;g\/dL; and 25% of the participants had a measurable CBLL (LOQ=3.3 &#956;g\/dl). Although the participants had several determinants of lead exposure, we only found a significant relationship with inside household determinants, such as presence of lead piping (p=0.026), unplastered walls (p=0.046) and peeling paint (p=0.048). Our results show that CBLL GM was similar to that reported in several studies conducted around the world. However, 25% of the participants might have some degree of risk for lead poisoning.","palabras_clave":"Lead exposure|Prenatal care|Blood lead level|cord lead level"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39676,"idioma_id":4,"titulo":"Effect of protein supplementation on tropical grass hay utilization by beef steers drinking saline water","resumen":"Concentrated separator by-product (CSB) is produced when beet molasses goes through an industrial desugaring process. To investigate the nutritional value of CSB as a supplement for grass hay diets (12.5% CP; DM basis), 4 ruminally and duodenally cannulated beef steers (332 ± 2.3 kg) were used in a 4 × 4 Latin square with a 2 × 2 factorial arrangement of treatments. Factors were intake level: ad libitum (AL) vs. restricted (RE; 1.25% of BW, DM basis) and dietary CSB addition (0 vs. 10%; DM basis). Experimental periods were 21 d in length, with the last 7 d used for collections. By design, intakes of both DM and OM (g\/kg of BW) were greater (P < 0.01; 18.8 vs. 13.1 ± 0.69 and 16.8 vs. 11.7 ± 0.62, respectively) for animals consuming AL compared with RE diets. Main effect means for intake were not affected by CSB (P = 0.59). However, within AL-fed steers, CSB tended (P = 0.12) to improve DMI (6,018 vs. 6,585 ± 185 g for 0 and 10% CSB, respectively). Feeding CSB resulted in similar total tract DM and OM digestion compared with controls (P = 0.50 and 0.87, respectively). There were no effects of CSB on apparent total tract NDF (P = 0.27) or ADF (P = 0.35) digestion; however, apparent N absorption increased (P = 0.10) with CSB addition. Total tract NDF, ADF, or N digestion coefficients were not different between AL- and RE-fed steers. Nitrogen intake (P = 0.02), total duodenal N flow (P = 0.02), and feed N escaping to the small intestine (P = 0.02) were increased with CSB addition. Microbial efficiency was unaffected by treatment (P = 0.17). Supplementation with CSB increased the rate of DM disappearance (P = 0.001; 4.9 vs. 6.9 ± 0.33 %\/h). Restricted intake increased the rate of in situ DM disappearance (P = 0.03; 6.4 vs. 5.3 ± 0.33 %\/h) compared with AL-fed steers. Ruminal DM fill was greater (P = 0.01) in AL compared with RE. Total VFA concentrations were greater (P = 0.04) for CSB compared with controls; however, ammonia concentrations were reduced (P = 0.03) with CSB addition. At different levels of dietary intake, supplementing medium-quality forage with 10% CSB increased N intake, small intestinal protein supply, and total ruminal VFA.","palabras_clave":"beef cattle|digestion|grass hay|intake|saline water|sulfate"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39677,"idioma_id":5,"titulo":"Morfología y anatomía de ejes caulinares, licofilos y esporangios de Phlegmariurus phylicifolius: un aporte a la sistemática de las Lycopodiaceae neotropicales","resumen":"El género Phlegmariurus (Herter) Holub   está dividido en 22 grupos informales. El grupo   Phlegmariurus phlegmaria posee plantas epifitas,péndulas, con licofilos dimórficos. Este grupo es   polifilético y reúne especies con convergencia   evolutiva. En Argentina está representado por   Phlegmariurus phylicifolius (Desv. ex Poir) B.   Øllg. Debido a que las especies de Phlegmariurus   requieren profundos estudios y revisiones, el   objetivo de este trabajo es describir morfológica   y anatómicamente tallo, licofilos y esporangios   de Phlegmariurus phylicifolius. Para realizar los   preparados anatómicos se utilizó material en FAA   y técnicas tradicionales de microscopia óptica.   Phlegmariurus phylicifolius presenta licofilos   dimorfos, los trofofilos reunidos en subverticilos de   tres, angostamente lanceolados a lineal subulados,   hipoestomáticos, uninervados, glabros y enteros.   El tallo presenta epidermis uniestratificada, con   gruesa pared tangencial externa y endodermis   uniestratificada. El tejido vascular forma una   plectostela de organización subradiada con cinco   polos de protoxilema. Los esporofilos son adpresos,   subdecusados o dispuestos en 3-4 hileras, ovados,   cuculados, con ápice obtuso. Los esporangios   poseen paredes típicas de Huperzioideae, son   de origen caulinar junto con los primordios de   licofilos y poseen un estomio formado por células   isodiamétricas más pequeñas que las adyacentes y   con paredes marcadamente engrosadas.","palabras_clave":"PHLEGMARIURUS PHYLICIFOLIUS|LYCOPODIACEAE |SISTEMÁTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39678,"idioma_id":4,"titulo":"Comparison of two proposed MLVA protocols for subtyping non-O157:H7 verotoxigenic Escherichia coli","resumen":"Multiple locus VNTRs analysis (MLVA) has become a reliable tool, able to establish genetic relationships for epidemiological surveillance and molecular subtyping of pathogens such as verotoxigenic Escherichia coli (VTEC). This emerging pathogen &nbsp;&nbsp;whose primary reservoir is the cattle causes severe disease in humans, such as hemorrhagic colitis and hemolytic uremic syndrome. With the aim of comparing a recently proposed MLVA assay with that used routinely in our laboratory, we analyzed a set of VTEC isolates (n=72) obtained from meat using both assays. All samples could be typed by the new MLVA assay and an increase in the number of distinct profiles (31 to 43) was observed. However, intraserotype resolution was not significantly enhanced, thus the incorporation of more VNTR loci is still needed to achieve a greater discrimination among non O157:H7 serotypes.","palabras_clave":"VTEC|MLVA|non-O157 serotypes|raw products"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39679,"idioma_id":4,"titulo":"Hybrid organic inorganic macromolecular photoinitiator system forvisible-light photopolymerization","resumen":"Hybrid organic-inorganic macrophotoinitiator bearing pendant tertiary amine groups (OI-AH) was prepared by hydrolytic condensation of a silane containing amino groups. The macromolecular amino-functionalized photoinitiator was used in combination with camphorquinone (CQ) for visible-light photo-polymerization. The OI-AH was incorporated into methacrylate resins at loadings between 1 and 10 wt.%. The photodecomposition of the CQ\/OI-AH in methacrylate monomers under visible light irradiation (470 nm) was examined. The photolysis products of CQ\/OI-AH were transparent at the irradiating wavelengths; consequently, the consumption of the CQ is accompanied by increased light intensity in the underlying lays. The clean and rapid photobleaching of CQ in combination with OI-AH makes this photoinitiator system very attractive for polymerization of thick sections. The evolution of monomer conversion versus irradiation time showed that the OI-AH is an efficient co-initiator of CQ because a fast reaction and high conversion of methacrylate groups result after 60 s irradiation with a LED source of 140 mW.","palabras_clave":"PHOTOPOLYMERIZATION|MACROPHOTOINITIATOR|HYBRID ORGANIC-INORGANIC|SOL-GEL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39680,"idioma_id":4,"titulo":"First report of isolation and molecular characterization of bubaline herpesvirus 1 (BuHV1) from Argentinean water buffaloes","resumen":"Herpesviruses have mainly co-evolved with their hosts for   millions of years. However, bovine herpesvirus 1 (BoHV1) and related ruminant   alphaherpesviruses have been reported to cross the species barrier. Bubaline   herpesvirus 1 (BuHV1) is an alphaherpesvirus closely related to BoHV1 and BoHV5.   According to the serological cross-relationships between ruminant   alphaherpesviruses, several surveys have studied the occurrence of BoHV1-related   virus infection in wild and domestic ruminant species. Recent studies in   Argentina showed an increase in serological prevalence against BoHV1 related   viruses in water buffaloes (Bubalus bubalis)   population. The aim of this study was to investigate the presence of related   ruminant alphaherpesvirus in the Argentinean water buffalo population. BuHV1 was   successfully isolated from 5 out of 225 buffaloes analyzed. One isolate was   obtained from nasal secretions, and the others were from vaginal swabs. The   buffaloes belonged to four different farms located in northeastern Argentina.   The isolates were characterized as alphaherpesvirus by direct immunofluorescence   using FITC-anti-BoHV1 IgG.   Restriction analysis performed with BamHI and BstEII on the complete genome showed differences between   the isolates and those from BoHV1 and BoHV5 subtypes. Phylogenetic analysis on   both UL27 and US6 showed similarity in tree topology. While three of the   isolates grouped together with sequences of BoHV5, two other isolates clustered   separately. Genetic analysis of eight concatenated sequences from all isolates   and references strains showed high nucleotide sequence identity between BuHV1   and BoHV5. While three of the isolates clustered together with the BoHV5   reference strain, the last two isolates were closely related to an Australian   BuHV1 strain. To our knowledge, this is the first report on the isolation and   molecular characterization of BuHV1 in South America. Phylogenetic analysis   suggested that two different BuHV1 lineages circulate in the Argentinean water   buffalo population.","palabras_clave":"Isolatiom|molecular|herpes virus|1 (BuHV1)"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39681,"idioma_id":5,"titulo":"Dinámica de la humedad de los combustibles y su relación con la ecología y el manejo de fuego en la región chaqueña occidental (Argentina) I: conceptos básicos","resumen":"El fuego es un modelador de la mayoría de los ecosistemas vegetales del mundo, entre ellos, los correspondientes a la región chaqueña argentina donde asimismo ha sido usado ampliamente como una herramienta de manejo de la vegetación. Dada una fuente de ignición, para que un fuego pueda prosperar deben existir ciertas condiciones. Entre ellas, el contenido de humedad del combustible (CH) juega un rol fundamental ya que su magnitud influirá en la probabilidad de ignición, en el posterior comportamiento del fuego y en el impacto que éste tendrá sobre el ecosistema afectado. Existen diferencias entre el contenido de humedad de los combustibles vivos (CHCV) y el de los muertos (CHCM), debido a que el contenido del agua en cada uno de ellos responde a procesos distintos. Mientras que el CHCV responde a características propias de las especies como su fisiología y fenología, el CHCM varía de acuerdo a leyes físicas universales que regulan el intercambio de humedad entre ese combustible y el ambiente que lo rodea. Dada la relevancia que tiene CH, se han desarrollado diversos métodos y sistemas para medirlo, estimarlo, y\/o poder predecirlo. Conocer su dinámica a lo largo del tiempo permite, además, determinar los períodos en los que el fuego es más propenso a ocurrir en cada ecosistema. Al presente, se han realizado estudios preliminares para algunas especies de la región chaqueña. Para el desarrollo de indicadores de peligro y modelos de comportamiento que permitan llevar a cabo quemas prescriptas con un mayor grado de seguridad y mejor cumplimiento de los objetivos, es necesario incrementar este conocimiento a un mayor número de especies. El objetivo de este trabajo fue, por lo tanto, ampliar la información existente, cuantificando la dinámica estacional del CH en diferentes especies nativas de gramíneas, arbustos y árboles de la región chaqueña. Además analizamos los efectos de la estación climática, el sitio ecológico y las características del combustible sobre el CH. En esta primera parte, presentamos las bases conceptuales sobre la combustión de los vegetales y su relación con el CH, las características que hacen a las diferencias entre combustibles vivos y muertos, los factores que inciden en sus respectivas dinámicas, y las metodologías que existen para su determinación. En los siguientes aportes se darán a conocer estas determinaciones en las principales especies de la región chaqueña argentina.","palabras_clave":"COMBUSTIÓN|TIPO DE COMBUSTIBLE|INCENDIOS FORESTALES|QUEMAS PRESCRIPTAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39682,"idioma_id":4,"titulo":"In Vitro Toxicity Evaluation of Hydrogel Carbon Nanotubes Composites on Intestinal Cells","resumen":"Composite materials based on carbon nanotubes (CNT) and polymeric hydrogels have become the subject matter of  major interest for use as carriers in drug delivery research. The aim of this study was to evaluate the in vitro cytotoxicity of the  hydrogel?carbon nanotube?chitosan (hydrogel?CNT?CH) composites on intestinal cells. Oxidized CNT were wrapped with chitosan  (CH), Fourier transform infrared (FT-IR) analysis suggest that oxidized CNT interact with CH. Transmission electron microscopy  (TEM) images show a CH layer lying around CNT. Chitosan wrapped CNT were incorporated to poly (acrylamide-co-acrylic acid)  hydrogels. Swelling behavior in buffers at different pH were evaluated and revealed a significantly lower swelling when it is exposed  to a acid buffer solution (pH 2.2). Mechanical properties were evaluated by measurements of elasticity and the material with CNT  showed better mechanical properties. The incorporation and liberation of Egg Yolk Immunoglobulin from hydrogel?CNT?CH were  also assessed and it revealed an improved performance. To evaluate the effect of these nanocomposites on cellular redox balance,  intestinal cells were exposed to hydrogel?CNT?CH composites and antioxidant enzymes were assessed. Cytotoxicity and apoptosis  were also evaluated. Hydrogel?CNT?CH composites induce no oxidative stress and there were no evidence of cytotoxicity or cell  death. These preliminary findings suggest that hydrogel?CNT?CH composites show improved properties and good biocompatibility  in vitro making these biomaterials promising systems for drug delivery purposes.","palabras_clave":"BIOCOMPATIBILITY|GELS COMPOSITES|GRAPHENES AND FULLERENES|CARBON NANOTUBE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39683,"idioma_id":5,"titulo":"Región Pampeana: Geografía y bienestar según subregiones (2010)","resumen":"Más allá de la imagen positiva que, en términos generales, se tiene de la Región Pampeana, esta presenta fuertes asimetrías internas. Este trabajo se propone medir y contribuir a la explicación de estas inequidades a través del análisis de un conjunto de indicadores socioeconómicos y ambientales significativos del grado de bienestar de su población. La información a nivel departamental (219 unidades) se analizará considerando, asimismo, sus subregiones.","palabras_clave":"Desigualdades socioespaciales |calidad de vida|SIG|región pampeana"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39684,"idioma_id":4,"titulo":"High Resistance Connection Detection in Induction Motor Drives using Signal Injection","resumen":"Two new methods for high-resistance connection  (HRC) diagnosis in induction motor (IM) drives are presented in  this effort. These automatic offline methods are based on a signal  injection strategy applied to the IM at standstill. By measuring  the voltage in the machine neutral point and phase currents, it is  possible to detect and isolate connection problems. Experimental  results showing a good sensitivity to HRCs and immunity to symmetrical  stator resistance variations were obtained in a laboratory  setup.","palabras_clave":"High-Resistance Connection|Induction motor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39685,"idioma_id":4,"titulo":"Oral administration of Shiga toxin-producing Escherichia coli induces intestinal and systemic specific immune response in mice","resumen":"Hemolytic uremic syndrome (HUS) is the major complication of gastrointestinal infections with enterohemorrhagic Escherichia coli (EHEC) and is mediated by the production of Shiga toxins (Stx). Although it has been previously reported that not only HUS patients but healthy children have anti-Stx antibodies, very little is known about how these infections impact on mucosal immune system to generate a specific immune response. This work aimed to evaluate the immune responses elicited after a single oral dose of EHEC in a mouse model of HUS at weaning. We found sequential activation of T and B lymphocytes together with an increased percentage of IgA-bearing B cells in Peyer´s patches and mesenteric lymph nodes. We also found fecal anti-EHEC IgA and serum anti-Stx2 IgG in EHEC-inoculated mice. Besides, these mice were partially protected against an intravenous challenge with Stx2. These data demonstrate that one episode of EHEC infection is enough to induce activation in the gut-associated lymphoid tissue, especially the B cell compartment, and lead to the production of specific IgA in mucosal tissue and the generation of systemic protection against Stx2 in a percentage of intragastrically inoculated mice. These data also support the epidemiologic observation that a second episode of HUS is very rare","palabras_clave":"HUS|EHEC|Stx2|mucosal immunology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39686,"idioma_id":4,"titulo":"Preparation of NiNbO\/AISI 430 Ferritic Stainless Steel Monoliths for Catalytic Applications","resumen":"AISI 430 ferritic stainless steel was used as substrate to make  catalytic monolithic structures. In order to increase the surface roughness of the substrate, the steel was oxidized at a temperature range of 900-940 °C and in a time range of 30-120 min. The oxide layer formed was characterized. Treatments at 940 °C for 60 min were found optimum to obtain a Cr-rich rough oxide layer, with good adherence and homogeneity.  Catalytic monoliths were prepared by dip-coating into four different slurries containing the NiNb mixed oxide catalyst. The samples were characterized and tested in the oxidative dehydrogenation (ODH) of ethane to ethylene.  The structured catalysts were active for the ODH of ethane, with very good  selectivity to ethylene. The catalytic performance was remarkably constant for 170 h in stream at 400 °C.","palabras_clave":"NiNb MIXED OXIDE|AISI-430|MONOLITHIC CATALYST|OXIDATIVE DEHYDROGENATION|ETHANE|ETHYLENE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39687,"idioma_id":4,"titulo":"Light coupling in single-track guiding structures obtained by femtosecond laser writing in lithium niobate","resumen":"In this Letter we present a study of light coupling into a pair of Type II waveguides made of lithium niobate crystals by using femtosecond laser writing. Simulations based on the beam propagation method and optical fiber coupling experiments with the guiding structures showed good agreement. The presented results can be a suitable tool for designing high-performance optical circuits using femtosecond laser writing techniques for different technological requirements.","palabras_clave":"lithium niobate|waveguide |coupling|femtosecond"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39688,"idioma_id":4,"titulo":"Association between testosterone levels and the metabolic syndrome in adult men","resumen":"Objective: To evaluate the relationship between testosterone levels and the metabolic syndrome (MS) in men older than 45 years.Methods: Six hundred and sixty men (45?70 years) selected from 2906 participants of a population screening for prostate cancer were included in this study. Testosterone and the components of MS were assessed in all men. MS was diagnosed according to NCEP-ATP III criteria. Triglycerides (TG)\/HDL-cholesterol (chol) index was calculated.Results: The presence of MS was inversely associated with testosterone (÷2, p&#8201;&lt;&#8201;0.001), independently of age (OR 0.802, CI 95%: 0.724?0.887, p&#8201;&lt;&#8201;0.0001). Hypertension was the most frequent abnormality observed followed by elevated TG and waist circumference (WC). Testosterone correlated positively with HDL-chol (r: 0.14, p&#8201;&lt;&#8201;0.0001) and negatively with body mass index (BMI)(r: &#8722;0.29, p&#8201;&lt;&#8201;0.0001), WC (r: &#8722;0.26, p&#8201;&lt;&#8201;0.0001), TG (r: &#8722;0.20, p&#8201;&lt;&#8201;0.0001), TG\/HDL-chol (r: &#8722;0.20, p&#8201;&lt;&#8201;0.0001), glucose (r: &#8722;0.11, p&#8201;=&#8201;0.005) and MS score (r: &#8722;0.23, p&#8201;&lt;&#8201;0.0001).Conclusions: Our results show that in men older than 45 years, as long as testosterone levels decline, the prevalence of MS increases, independently of age. The correlations found between testosterone and four of the five components of MS, as well as with BMI and TG\/HDL-chol ratio, a surrogate marker of insulin resistance, suggest considering male hypogonadism as a determinant of developmental abnormalities typical of MS.","palabras_clave":"testosterone|metabolic syndrome|insulin resistance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39689,"idioma_id":4,"titulo":"Simulation of Electric Vehicles Combining Structural  and Functional Approaches","resumen":"In this paper the construction of a model that represents the behavior of an ElectricVehicle is described. Both the mechanical and the electric traction systems are represented usingMulti-Bond Graph structural approach suited to model large scale physical systems. Then the model ofthe controllers, represented with a functional approach, is included giving rise to an integrated modelwhich exploits the advantages of both approaches. Simulation and experimental results are aimed toillustrate the electromechanical interaction and to validate the proposal.","palabras_clave":"Modeling and simulation|Electric Vehicles|Multi-Bond Graph"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39690,"idioma_id":4,"titulo":"Ultra-Compact Dwarfs around NGC 3268","resumen":"We present radial  velocities (from Gemini\/GMOS) of the second sample of ultracompact dwarfs (UCDs) and bright globular clusters (GCs) in the Antlia cluster. 23 objects are located around the giant elliptical NGC 3268, and one is close to the fainter lenticular NGC 3273. Together with previously found UCDs around NGC 3258, a total of 35 UCDs and bright GCs  has been now identified in the Antlia cluster. Their colours and magnitudes are compared with those of the nuclei of dE,N galaxies already confirmed as Antlia members. For a subsample that lie on ACS (Advanced Camera for Surveys) images and are brighter than MV = &#8722; 9 mag, the   effective radii (Reff ) have been measured, the maximum radius being approximately 10 pc. In addition to the radial velocity sample, we find 10 objects in the magnitude range corresponding to GCs but with   10 &lt; Reff &lt;  17 pc, resembling the so-called extended clusters. By number and magnitude, the new UCDs fit to the GC luminosity function, supporting their interpretation as bright GCs. Additionally, we use a tracer mass estimator to calculate the mass enclosed up to approx. 47 kpc from NGC 3268, which results in 2.7 x 10^12 solar masses.","palabras_clave":"STAR|CLUSTERS|PHOTOMETRY|NUCLEI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39691,"idioma_id":4,"titulo":"La comunicación organizacional y sus fracturas.","resumen":"Esta presentación se basa en un proyecto de investigación&nbsp; cuya área de problematización trata las condiciones de surgimiento de un sistema acosador en el ámbito laboral, las formas en que tiene lugar&nbsp; y las características con las que se estructura.Los objetivos de indagación del proyecto orientaron la búsqueda de las formas iniciales del acoso hacia la detección de los incidentes críticos&nbsp; (Flanagan, 1954; Edvardsson, 1992). Partiendo de las condiciones facilitadoras que puedan dar lugar al surgimiento de un sistema acosador, subrayamos la gradualidad de su emergencia, tanto en el tiempo como en el espacio. Desde este punto de vista entendemos que en el transcurso de este devenir se produce un incidente particular, al que denominamos crítico debido a que, a partir de su manifestación disruptiva en las interacciones y experiencia cotidiana del trabajo, comienza a visualizarse más claramente la expresión de hostigamiento. (Flanagan, 1954; Edvardsson, 1992)&nbsp; A partir de ese momento comienza a percibirse o a visualizarse francamente la manifestación de la hostilidad. Muchas veces, el sujeto afectado no&nbsp; encuentra motivos para que ese hostigamiento pueda organizarse significativamente desde sus referencias habituales. Sobre todo si el surgimiento del incidente crítico se vincula con una situación en la que previamente el mismo sujeto trasgredió sin proponérselo alguna norma de operancia implícita para el grupo o para alguna persona en posición jerárquica. No tiene un saber en términos de intencionalidad sobre lo que hizo o trasgredió. En ese caso frecuentemente necesita una ayuda para reconstruir lo sucedido. En términos generales el desconcierto que desata la percepción de tales inconsistencias produce un estado subjetivo temporal de perturbación para el destinatario del hostigamiento. La puesta en cuestión de lo que siente y piensa acerca de lo que le está ocurriendo es un claro ejemplo de lo que un incidente crítico puede desatar. Cuando la recurrencia de los comportamientosde destrato en el marco de la&nbsp; práctica social en el trabajo pasa de ser un incidente a instalarse en un período sostenido, la identificamos como situación de acoso. Son modalidades que producen cambios bruscos y dificultades diversas en los intercambios. La tensión emocional, el desgaste psíquico y la exigencia de improvisar respuestas ante la ocurrencia inesperada, inquietante o incoherente de actitudes de hostigamiento se traduce finalmente en una situación desestabilizante que impacta en los planos cognitivo, social y emocional de los afectados. ","palabras_clave":"comunicacion|organización|-"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39692,"idioma_id":5,"titulo":"Introducción a la fotografía hemisférica  en ciencias forestales","resumen":"La fotografía hemisférica es profusamente utilizada en climatología y ciencias forestales en vinculación con tecnología geomática. Permite obtener un registro detallado de los claros del dosel y estimar, tanto la estructura del mismo, como la transmisión de luz al sotobosque, ambas variables de gran importancia para el inventario forestal y el manejo de la regeneración natural. Debido a que los equipos de fotografía hemisférica tienen usos muy diversos, incluso en fotografía artística, su costo es bajo en comparación con instrumentos específicos. Para utilizar esta técnica correctamente se requiere de conocimientos particulares de óptica, fotografía y procesamiento digital de imágenes. El objetivo del trabajo es explicar el principio de funcionamiento de la fotografía hemisférica en estimación de parámetros estructurales de bosques. Para ello se discute sobre óptica y fotografía, procesamiento digital de imágenes y estimación de parámetros estructurales. Conocer estos aspectos es relevante para adquirir un equipo, capturar fotografías en el terreno y utilizar softwares específicos para su procesamiento. Las fotografías son archivos raster, los cuales pueden entenderse como una matriz de n filas por m columnas, donde cada celda es un pixel. Para que un raster se visualice como una imagen es necesario establecer un espacio y una profundidad de color. Es importante tener en cuenta que en la captura de la fotografía se producen muchos errores, ya que dependiendo de la región geográfica es muy difícil satisfacer las condiciones ideales de iluminación.","palabras_clave":"Apertura del dosel|Fotografías ojo de pez|fracción de claros|índice área foliar|procesamiento digital imágenes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39693,"idioma_id":4,"titulo":"A New Synonym in Senna, Series Aphyllae (Leguminosae, Caesalpinioideae)","resumen":"Abstract?Multivariate and univariate analyses based on morphological characters were carried out in order to understand the taxonomic status of Senna spiniflora and S. chacoe ¨nsis. Fifteen morphological characters from herbarium specimens were recorded and analyzed by the Kruskal-Wallis test and principal components analysis. The type specimens and all available herbarium material were examined for the taxonomic study. The results showed that the taxa differed only by the character of stem pubescence and this feature displayed high variability. In parallel, the principal components analysis demonstrated that no clearly separated groups were recognized. Based upon these results, the synonymy of S. chacoe ¨nsis to S. spiniflora is proposed.","palabras_clave":"Aphyllae|Morphometrical analysis|quantitative characters|senna"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39694,"idioma_id":5,"titulo":"Funciones de los canales iónicos CFTR Y ENAC en la fibrosis quística","resumen":"La fibrosis quística se debe a la ausencia o defecto del canal transmembrana regulador de la fibrosis  quística (CFTR), un canal de cloruro codificado en el gen cftr que juega un papel clave en la homeostasis del agua e iones. El CFTR es activado por el AMPc y se localiza en las membranas apicales y basolaterales de las vías aéreas, intestino y glándulas exocrinas. Una de sus funciones primarias en los pulmones es mantener la capa de líquido superficial a través de su función de canal y regular el canal epitelial de sodio sensible al amiloride (ENaC). Se han identificado más de 1900 mutaciones en el gen cftr. La enfermedad se caracteriza por secreciones viscosas en las glándulas exocrinas y por niveles elevados de cloruro de sodio en el sudor. En la fibrosis quística el CFTR no funciona y el ENaC está desregulado; el resultado es un aumento en la reabsorción de sodio y agua con la formación de un líquido viscoso. En las glándulas sudoríparas tanto el Na+ como el Cl- se retienen en el lumen causando una pérdida de electrolitos durante la sudoración y el NaCl se elimina al sudor. Así, los niveles elevados de NaCl son la base del test del sudor inducido por pilocarpina, un método de diagnóstico para la enfermedad. En esta revisión se discuten los movimientos de Cl- y Na+ en las glándulas sudoríparas y pulmón así como el papel del ENaC en la patogénesis de la enfermedad.","palabras_clave":"FIBROSISQUÍSTICA|CFTR|ENAC|MOVIMIENTOSIÓNICOS|CITOESQUELETO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39695,"idioma_id":4,"titulo":"Experimental study and numerical modeling of the freezing process of marine products","resumen":"An increasing interest in the exploitation of new Patagonian marine crabs was manifested by the industry, due to their commercial value as frozen products. In the present work the freezing of two products: crab meat in plastic pouches and crab claws was experimentally conducted and numerically modeled. Non linear, non-stationary heat conduction partial differential equations were solved to simulate the freezing of pouches, using a computational program in finite elements coded by the authors. The freezing of crab claws was simulated considering the irregular geometry of the system and two domains with different thermal properties (crab meat in contact with a calcareous layer) using Heaviside and Gaussian functions, to obtain a smoother specific heat curve. Heat transfer coefficients in the industrial tunnel freezer were determined from independent experiments. The influence of the freezing rate on the size of the ice crystals was determined by histological observations. Numerical models were satisfactorily validated by means of experimental time?temperature curves obtained at industrial scale in freezing tunnels. Tracking of the warmest point paths in each product was performed. These simulations are of great value for food process design and can help to optimize and control the freezing of new products.","palabras_clave":"Marine product|Freezing|Numerical simulation|Crab|Heat transfer|Mathematical modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39696,"idioma_id":4,"titulo":"Field and laboratory studies to determine the suitability of Cissoanthonomus tuberculipennis (Coleoptera: Curculionidae) for release against Cardiospermum grandiflorum (Sapindaceae) in South Africa","resumen":"Cardiospermum grandiflorum is an invasive creeper that was targeted for biological control in South Africa in 2003. To determine ecological host range of its natural enemies, surveys were conducted on C. grandiflorum and 11 other Sapindaceae at 40 sites in the weed?s native range (Argentina). These surveys indicated that the seed-feeding weevil Cissoanthonomus tuberculipennis was restricted to C. grandiflorum, and that it was among the common natural enemies, occurring at most sites where C. grandiflorum was recorded. Open-field tests were conducted under natural conditions in Argentina to determine the host preference of C. tuberculipennis and other natural enemies of C. grandiflorum among three Cardiospermum species. These tests revealed that C. tuberculipennis and the bug Gargaphia sp. were restricted to C. grandiflorum though the latter subsequently developed on non-target Cardiospermum species in the laboratory. C. tuberculi- pennis was found to be highly damaging, destroying up to 44% of the seeds per plant in Argentina. In all the host-specificity tests, including no-choice, paired- choice and multi-choice tests, C. tuberculipennis only fed and developed on C. grandiflorum. Failure of C. tuberculipennis to feed and develop on all congeners of C. grandiflorum shows that the weevil is highly host-specific to the target weed. Results of host-specificity tests, open field tests and long-term monitoring of C. tuberculipennis populations demonstrate that the weevil poses no threat to non- target plant species, and therefore safe for release against C. grandiflorum in South Africa. Permission to release C. tuberculipennis in South Africa has been granted by the relevant regulatory authorities.","palabras_clave":"Cardiospermum grandiflorum|Cissoanthonomus tuberculipennis|ecological host range|host-specificity tests"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39697,"idioma_id":5,"titulo":"'La resocialización carcelaria. Su permanencia y sus cambios.","resumen":"A partir del análisis del campo del control del delito y la justiciapenal en Norteamérica e Inglaterra, David Garland sostiene quedesde la década de los ?70 en adelante se opera un giro en tornoa la forma en que se considera cómo debe ser tratado quien escondenado por el sistema penal. El argumento central es que lamodernidad tardía trajo una serie de riesgos, inseguridades yproblemas de control que han moldeado las formas de respuestafrente al delito. Es en este sentido que afirma que existe undeclive del ideal ?rehabilitador? y que, a la vez, este declive va dela mano de la reinvención de la prisión. Por ejemplo, en EstadosUnidos, a pesar de que hay tasas de delito decrecientes, lastasas de encarcelamiento aumentaron en los últimos 30 años.La prisión criticada a lo largo de toda su historia, emerge comola herramienta privilegiada del control penal","palabras_clave":"Cárcel|Resocialización|Cambios|Continuidades"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39698,"idioma_id":4,"titulo":"A chemometric approach: characterization of quality and authenticity of artisanal honeys from Argentina","resumen":"ABSTRACT: The demand of honey with defined quality has increased around the world, therefore an adequately description of traceability and authenticity of honeys is necessary. The pollen and physicochemical characteristics of 58 honey samples collected from 5 different Environmental Units (EUs) of the Jujuy province (Argentine) were determined, in order to differentiate them by geographical origin through the application of chemometrics methods. A qualitative pollen analysis was performed by microscopy. The physicochemical characteristics were determined by AOAC methods. Correspondence Analysis (CA), Principal Component Analyses (PCA) and Linear Discriminant Analyses (LDA) were performed. Forty-five percent of honeys were monofloral; nearly half of them correspond to native species, among which Salix humboldtiana, Baccharis sp. and Ziziphus mistol stood out. Physicochemical and microbiological analysis showed acceptable quality for honeys. CA characterized significantly honeys from different 4 EUs using all pollen data. While Forward Stepwise coupled to LDA identified 14 significant variables to build a discriminatory model with three significant discriminant functions, reaching a cumulative variance of 94%. Thus 86% of the samples were correctly classified. PCA and LDA applied to physicochemical data, allowed to distinguish three different groups with a significant function (p&lt;0.01) that explained 90% of the total variability. Honeys corresponding to EU III 'Subandean Hills of Santa Barbara' was the best classified by pollen and physicochemical data. The application of chemometrics methods to pollen data and physicochemical parameters may be a useful tool to determine honey geographical origin.","palabras_clave":"HONEY|MELISSOPALYNOLOGY|PHYSICOCHEMICAL PROPERTIES|CHEMOMETRIC METHODS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39699,"idioma_id":4,"titulo":"A double-hit model of stress dysregulation: Implications for limbic glucocorticoid receptors and anxiety under amitriptyline treatment","resumen":"Adversity during early life can lead to diverging endocrine and behavioral responses to stress in adulthood. In our laboratory, we evaluated the long-term effects of early life adversity and its interaction with chronic stress during adulthood. We propose this as a model of vulnerability to dysregulation of the stress response. We hypothesized that rats subjected to both protocols would show differential expression of corticosteroid receptors measured as number of neurons immunoreactive for glucocorticoid receptors (GR) or mineralocorticoid receptors (MR), in limbic areas related to the control of anxiety-like behavior. We also evaluated the effect of amitriptyline expecting to prevent the outcomes of the model. Male Wistar rats were separated from the mother (MS) for 4.5&#8201;h every day for the first 3 weeks of life. From postnatal day 50, rats were subjected to chronic variable stress (CVS) during 24&#8201;d (five types of stressor at different times of day). During the stress protocol, the rats were administered amitriptyline (10&#8201;mg\/kg i.p.) daily. MS evoked lower MR expression in the central amygdaloid nucleus and this was reversed by amitriptyline. Furthermore, CVS increased MR immunoreactivity in the hippocampal area CA2 and increased anxious behavior; both effects were prevented by the antidepressant. When MS was combined with CVS during adulthood, there was a reduction of locomotor activity, with no corrective effect of amitriptyline. The differential effects among groups could mean that MS would promote an alternative phenotype that is expressed when facing CVS (a double hit) later in life.","palabras_clave":"Stress|corticosteroid|amitriptyline|lymbic"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39700,"idioma_id":5,"titulo":"Caracterización química y evaluación sensorial de dulces novedosos elaborados con frutos de Geoffroea decorticans, Fabaceae","resumen":"En el presente trabajo de investigación se evaluó la posibilidad de elaborar  mermeladas (producto A) y dulce símil batata (producto B)  a partir de la pulpa comestible de los frutos de G. decortican.  Como primer paso se caracterizó químicamente la harina (parte mollar)  destacando el contenido de carbohidratos (85,6%), proteína (9,4%) y minerales (4,2%). Se  cuantificaron mediante cromatografía en fase gaseosa sacarosa (29,5%), glucosa (3,80%) y fructosa (5,30%). Se destaca en la mermelada el aporte de proteínas (5,7%), minerales (3,4%) y fibra dietaría (0,97%), sacarosa (46,8%), glucosa (1,9%) y fructosa (2,4%). El dulce símil batata  tiene bajo contenido calórico (140 Kcal\/100g) y  aporta  proteínas (4,6%).   Durante los 12 meses de almacenamiento, la mermelada  tuvo  buena estabilidad físico-química y microbiológica a pesar de ligeras fluctuaciones observadas durante el almacenamiento en el pH, contenidos de sólidos solubles y acidez total titulable. La  evaluación sensorial, arrojó resultado positivo, resultando aceptable ambos productos elaborados y con un 75% de preferencia del producto B sobre  A. También, se resalta el aporte de aminoácidos y minerales que aportan estos frutos como cualidad nutricional que se traducen luego en los productos elaborados.","palabras_clave":"FRUTOS DE GEOFFROEA DECORTICANS|DULCES|ANALISIS FISICO-QUIMICO|ANALISIS SENSORIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39701,"idioma_id":4,"titulo":"Chemical and nutritional characterization of fruits from Geoffroea decorticans tree (chañar) and their parts, from argentine subtropical forest","resumen":"Geoffroea decorticans, chañar, is an abundant tree in the north of Argentina and limiting countries. Its fruits  are rich in minerals, carbohydrate, protein and fibers. A novel approach was developed, where after coarse  milling and sieving of the fruits, exocarp and mesocarp is separated from the stones (endocarp and seed).  Subsequent fine grinding gave flours named A and B, respectively. But, in another original process, the  stones can be coarse milled and two new fractions can be obtained, C and D. Flour A representing 61% of  the fruit was low in crude fiber (CF, 5.13%) and fat (1.89%), but high in carbohydrate (81.95%) and protein  (8.90%). Flour B was higher in fat and fibers (6.66% and 46.8%), but lower in protein (5.02%). The  carbohydrate content was almost the same in both. Flour C had almost nothing of fat and minor quantities  of protein but was rich in fibers (47.0%). Flour D contained most of the stone protein and the remaining oil  in a 23 % concentration. The main minerals present in the different fractions were Ca, Mg, and Fe, while  heavy metals were not significant. Samples showed all essential amino acids in free state except the sulfur  ones, but the proteins presented all of them, with some fractions exceeding the chemical score of 100.  These results enable to suggest some of these flour fractions as raw material for food or feed.","palabras_clave":"CHAÑAR|FRUIT|PROXIMATE ANALYSIS|FLOURS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39702,"idioma_id":4,"titulo":"Remembering stories together: Social contagion and the moderating influence of disagreements in conversations","resumen":"Although remembering often occurs with conversations, the effects of its pragmatics on memory are rarely examined. We studied the effect of two pragmatic factors: (1) the presence of disagreeing and (2) the level of participation in the disagreement. In the present study, each participant read a slightly different version of four stories, thereby allowing for the possibility of social contagion through the conversation. They then jointly recounted the stories. We coded for the presence or absence of disagreements, and whether a participant contributed to the disagreement. Three factors mediated social contagion: (a) the presence or absence of an overt disagreement; (b) whether or not a member of a conversational remembering participated actively in a disagreement; and (c) how well participants remembered the original material. Both the pragmatics of conversations and quality of memory are important factors moderating social contagion.","palabras_clave":"Disagreements|Social Contagion|Conversational Remembering"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39703,"idioma_id":4,"titulo":"Genetic and morphological evidence reveals the existence of a new family, genus and species of Echinorhynchida (Acanthocephala)","resumen":"Gymnorhadinorhynchus gen. n. is proposed to accommodate its type species, G. decapteri sp. n., a parasite of the marine fish Decapterus punctatus (Cuvier), caught from the coastal waters of Brazil. Gymnorhadinorhynchus decapteri sp. n. was morphologically most similar to species of two echinorhynchid families, the Rhadinorhynchidae and the Cavisomidae, particularly in the structure of the proboscis and the absence of somatic spines, respectively. This combination of morphological features made it difficult to assign our specimen to an extant family of the Acanthocephala. Therefore, in order to clarify the systematic placement of G. decapteri, a molecular phylogenetic analysis was performed based on the SSU and LSU rDNA and the mitochondrial cox1 gene sequences obtained for the new taxon and other 26 acanthocephalan species. The results of parsimony and maximum likelihood analyses, using individual, combined and concatenated sequence data, consistently indicate that the specimens do not belong to any  known family of the Echinorhynchida. Rather, G. decapteri represents a distinct lineage that is closely related to the Transvenidae, but distantly related to both the Rhadinorhynchidae and the Cavisomidae. Gymnorhadinorhynchidae fam. n. is therefore erected. This newly described family can be distinguished from other families of Echinorhynchida by the combination of the following morphological characters: a proboscis cylindrical with 10 rows of 22?26 hooks, dorsoventral differences in proboscis hooks, basal hooks forming a ring and being abruptly larger than anterior hooks, absence of trunk spines and presence of four tubular cement glands. This combination, in addition to several molecular autapomorphies, justifies the erection of a new genus, Gymnorhadinorhynchus gen. n., in order to accommodate this new species.","palabras_clave":"Rhadinorhynchidae|Cavisomidae|Gymnorhadinorhynchidae|Taxonomy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39704,"idioma_id":4,"titulo":"In situ formed microparticles of PLGA from O\/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone","resumen":"In situ-formed microspheres are an alternative to expensive and complex manufactured preformed systems for the controlled release of drugs. The aim of this study was to evaluate the potential of stable O\/W emulsions to entrap progesterone after in vitro precipitation of poly(D,L-lactide-co-glycolide) (PLGA) microparticles. This was achieved by a solvent selection based on their miscibility and capability to solubilize the drug and PLGA. Stability assays, size distribution studies, and progesterone encapsulation efficiency evaluation were carried out for the candidate formulations. After selection of the most suitable formulations, in vitro-controlled release test of progesterone were done. Results demonstrate that emulsions based on triacetin and polyvinyl alcohol (PVA) aqueous solutions were useful solvent systems to obtain microspheres capable to deliver the hormone in a controlled release manner. In addition, for the first time, for these authors, PVAwas successfully implemented into a continuous phase to increase the stability of in situ-formed O\/W formulations. © Springer Science+Business Media 2014.","palabras_clave":"In situ-forming microspheres|Emulsion stability|Progesterone|PLGA|PVA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39705,"idioma_id":4,"titulo":"Suzuki-Miyaura cross-coupling of aryl iodides and phenyl boronic acid over  palladium-free CeO2 catalysts.","resumen":"The Suzuki?Miyaura cross-coupling reaction between p-iodotoluene and phenylboronic acid is carriedout over a series of ceria catalysts, at 150&#9702;C, under N2 atmosphere, employing DMF as the solvent. The ceriacatalysts present different BET area (determined from N2 isotherms at 77 K), different Ce4+\/Ce3+ ratio (asmeasured by XPS), and different concentration and strength of acid sites (as measured by potentiometrictitration with n-butylamine). The activity of the different samples depends on the concentration andstrength of acid sites, although the participation of Ce3+ centers should not be neglected. Ceria catalystsare less active and less selective than a Pd\/SiO2 sample. Although the catalytic performance of ceriacatalysts is lower than the one corresponding to Pd\/SiO2, the fact that a transition metal-free catalyst isactive for SM reaction is highlighted.","palabras_clave":"Ceria|Suzuki-Miyaura|cross coupling|acid sites"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39706,"idioma_id":4,"titulo":"Developmental programming: prenatal steroid excess disrupts key members of intra-ovarian steroidogenic pathway","resumen":"Prenatal testosterone (T) excess  disrupts ovarian cyclicity, increases circulating estradiol levels as well as  follicular recruitment and persistence culminating in multifollicular ovarian  morphology similar to women with PCOS. We tested whether prenatal T excess, by  androgenic or estrogenic action, disrupts the steroid biosynthetic machinery in  a cell, follicle stage, age and treatment-specific manner consistent with the  ovarian disruptions and increased estradiol release. Impact of T \/ dihydrotestosterone  (DHT) treatments from days 30-90 of gestation on STAR, HSD3B, CYP17A1 and CYP19A1  were examined on fetal day 90, 140, 10 months (postpubertal) and 21 months  (adult, no DHT group) of age by immunohistochemistry. All 4 markers changed in  a cell, follicle stage, and age-specific manner. Both treatments increased STAR expression in  preantral follicles of postpubertal and adult females. Effects of prenatal T  and DHT on HSD3B differed in a follicle and age-specifc manner. CYP17A1 was reduced in the theca  interna of antral follicles by T, but not DHT in 10 and 21 month old females.  CYP19A1 was reduced by both T and DHT at all ages barring an increase on fetal  day140. Reduced granulosa cell CYP19A1 and thecal CYP17A1 in adults likely  disrupt the intrafollicular androgen \/ estrogen balance contributing to  follicular persistence. The reduced thecal CYP17A1 expression suggest the hyperandrogenic ovarian  phenotype may originate from increased enzyme activity or alternatively via a  diferent isoform of CYP17.&nbsp; The reduced  CYP19A1 in antral follicles of adults indicates that the increased circulating  estradiol release likely arises from the increased number of persisting  follicles. ","palabras_clave":"reprogramacion ovarica|Esteroides|ovario"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39707,"idioma_id":5,"titulo":"Efecto de la adición de harinas no tradicionales en las características nutricionales de productos libres de gluten","resumen":"Los productos farináceos sin glutenson formulados con harinas y\/o almidones refinados y generalmente aportan bajascantidades de proteínas, minerales y fibra. La complementación de esosproductos podría incrementar la calidad nutricional de las dietas libres degluten. Los cultivos andinos son adecuados para realizar la complementación. Elhaba (vicia faba) y la quínoa (Chenopodium quinoa) presentan proteínas que secomplementan adecuadamente con las de cereales, alto contenido de algunasvitaminas, hierro, fibra dietaria y componentes funcionales. El objetivo deltrabajo fue caracterizar nutricionalmente fideos de harinas mezclas maíz\/haba ymaíz\/quínoa. Las mezclas utilizadas fueron harina maíz\/quínoa (M\/Q) 80:20 ymaíz\/haba (M\/H) 70:30, para elaborar fideos tipo espaguetis porextrusión-cocción. Se determinó composición proximal, contenidos de minerales,fibra dietaria, ácidos grasos, Utilización Proteica Neta (UPN), Digestibilidad(D) y Valor Biológico (VB). Los fideos mejorados nutricionalmente mostraron unincremento significativo de macro y micronutrientes, como así también de UPN yVB y una ligera disminución en la D respecto a la harina de maíz pura utilizadacomo control. Una porción de estos fideos aporta 10-20% del valor diariorecomendado de fibra dietaria. El agregado de harinas de habas y quínoa asistemas farináceos sin gluten permite obtener fideos con característicastecnológicas adecuadas y calidad nutricional mejorada","palabras_clave":"HARINAS NO TRADICIONALES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39708,"idioma_id":4,"titulo":"Characterization of nutrient profile of Quinoa (Chenopodium Quinoa), Amaranth (Amaranthus caudatus), and Corn purple (Zea mays L) consumed in the North of Argentina Proximates, Minerals and Trace elements","resumen":"Quinoa, amaranth and purple corn are Andean cereals largely consumed in North of Argentina. Nutrient  analysis with the purpose of inclusion in the Argentinean FCDB and e-search EuroFIR has become urgent  matter. In this work proximate and mineral profile of Andean cereals cultivated in the North of Argentina  were determined and compared with rice. Proximate analysis showed that Andean cereals have similar  profile but significantly higher (p < 0.05) than rice. Andean cereals are rich sources of iron, copper, manganese  and zinc and better than rice. Phosphorus and magnesium quinoa content could contribute up to  55% of consumers DRI. Andean cereals and rice are poor sources of potassium. To guarantee the interchange  of data among users and producers of FCDB component values were obtained in compliance with  EuroFIR guidelines for compilation process. Present work provides necessary information to FCDB users  who wish to have access to food reference analytical parameters","palabras_clave":"ANDEAN CEREALS   | FOOD COMPOSITION DATABASE|DATA QUALITY |EUROFIR|QUALITY ASSURANCE|GLUTEN-FREE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39709,"idioma_id":4,"titulo":"Preliminary assessment of the geothermal potential of Rosario de la Frontera area (Salta, NW Argentina): Insight from hydro-geological, hydro-geochemical and structural investigations","resumen":"This work is part of a project aimed to the development and application of hydrogeological, hydrogeochemical and geological methodologies for the study of the geothermal system of Rosario de La Frontera (NW Argentina).  The surface thermal manifestations of this area, whose temperatures range from 22.6 to 92.6 C, are mainly located in the northern sector of Sierra de la Candelaria anticline. This regional structure crops out between the provinces of Salta and Tucuman (NWArgentina), at the foothills of the central Andean retrowedge.  The present investigation focuses on hydrogeological and structural data, and isotopic compositions (18O, D and 3H) of thermal springs. Preliminary results allowed to define: i) the meteoric origin of spring water and their long (more than 50 years) residence time at depth, ii) a positive water balance, ranging between 2 and 4 millions of m3\/yr,and iii) a conservative geothermal reservoir volume of about 39 km3, iv) a eothermal potential with Er ¼ 5.6*1018 J and Ef ¼ 0.8*1018 J.","palabras_clave":"ANDES RETROWEDGE|GEOTHERMAL FLUIDS|WATER BALANCE|STABLE ISOTOPES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39710,"idioma_id":4,"titulo":"CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions","resumen":"DNA damage, which perturbs genomic stability, has been linked to cognitive decline in the aging human brain, and mutations in DNA repair genes have neurological implications. Several studies have suggested that DNA damage is also increased in brain disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. However, the precise mechanisms connecting DNA damage with neurodegeneration remain poorly understood. CDK5, a critical enzyme in the development of the central nervous system, phosphorylates a number of synaptic proteins and regulates dendritic spine morphogenesis, synaptic plasticity and learning. In addition to these physiological roles, CDK5 has been involved in the neuronal death initiated by DNA damage. We hypothesized that p19INK4d, a member of the cell cycle inhibitor family INK4, is involved in a neuroprotective mechanism activated in response to DNA damage. We found that in response to genotoxic injury or increased levels of intracellular calcium, p19INK4d is transcriptionally induced and phosphorylated by CDK5 which provides it with greater stability in postmitotic neurons. p19INK4d expression improves DNA repair, decreases apoptosis and increases neuronal survival under conditions of genotoxic stress. Our in vivo experiments showed that decreased levels of p19INK4d rendered hippocampal neurons more sensitive to genotoxic insult resulting in the loss of cognitive abilities that rely on the integrity of this brain structure. We propose a feedback mechanism by which the neurotoxic effects of CDK5-p25 activated by genotoxic stress or abnormal intracellular calcium levels are counteracted by the induction and stabilization of p19INK4d protein reducing the adverse consequences on brain functions.","palabras_clave":"Apoptosis|Beta amyloid peptide|DNA damage|Learning and memory|Neocarzinostatin|Neurodegeneration"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39711,"idioma_id":4,"titulo":"Numerical investigation of the double-arcing phenomenon in a cutting arc torch","resumen":"A numerical investigation of the double-arcing phenomenon in a cutting arc torch is reported. The dynamics of the double-arcing were simulated by using a two-dimensional model of the gas breakdown development in the space-charge layer contiguous to the nozzle of a cutting arc torch operated with oxygen. The kinetic scheme includes ionization of heavy particles by electron impact, electron attachment, electron detachment, electron?ion recombination, and ion?ion recombination. Complementary measurements during double-arcing phenomena were also conducted. A marked rise of the nozzle voltage was found. The numerical results showed that the dynamics of a cathode spot at the exit of the nozzle inner surface play a key role in the raising of the nozzle voltage, which in turn allows more electrons to return to the wall at the nozzle inlet. The return flow of electrons thus closes the current loop of the double-arcing. The increase in the (floating) nozzle voltage is due to the fact that the increased electron emission at the spot is mainly compensated by the displacement current (the ions do not play a relevant role due to its low-mobility) until that the stationary state is achieved and the electron return flow fully-compensates the electron emission at the spot. A fairly good agreement was found between the model and the experiment for a spot emission current growth rate of the order of 7x10^4 A\/s.","palabras_clave":"Plasma torch|Double arcing"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39712,"idioma_id":5,"titulo":"Efectos del tiempo de transporte, espera pre-faena y maduración en novillos sobre indicadores de estrés, calidad instrumental y sensorial de la carne","resumen":"     SUMMARY       We evaluated the effects of two    journey times (3 h vs 8 h), two lairage times (2 h vs 14 h) and    four ageing periods (4, 6, 8 and 15 d) on instrumental and sensory characteristics    of Longissimus dorsi from Angus steers (n = 64). Additionally, we evaluated    the effect of journey and lairage time on stress-related metabolites and    hormones. The instrumental analysis included final pH, meat colour, Warner Brätzler    shear force, cooking losses, water-holding capacity, and those obtained    in the texture profile analysis. The sensory parameters evaluated were odour,    flavour, initial and final tenderness, juiciness and connective tissue. Journey    time had no effect on most of the analysed variables. The longer lairage time    led to dehydration in the steers, increasing haematocrit and total plasma protein,    decreased glycemia and increased urinary concentration of cortisol. Regarding    instrumental quality of beef longer lairage time increased springiness and chewiness    in the texture profile analysis, while decreasing tenderness and juiciness at    sensory evaluation. The longer ageing time (15 days) decreased Warner Brätzler    shear force and hardness in the texture profile analysis, and increased tenderness    and juiciness in the sensory analysis. These results indicate that, under the    experimental conditions used in this study, journey times of up to 8 h did not    affect neither physiological indicators of stress nor beef quality, while longer    lairage time impaired both physiological indicators of stress and beef quality.    Ageing time of 15 days improved tenderness and juiciness of beef.","palabras_clave":"cattle transport| lairage|beef ageing |beef quality"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39713,"idioma_id":4,"titulo":"Synthesis and Characterization of Ammonium Acesulfamate","resumen":"Ammonium acesulfamate, (NH4)C4H4NO4S, was prepared by the reaction of acesulfamic acidand ammonium carbonate in aqueous solution, and characterized by elemental analysis and 1H and13C NMR spectroscopy. Its crystal and molecular structure was determined by single-crystal X-ray diffraction methods. The substance crystallizes in the orthorhombic space group Pnma with Z = 4 molecules per unit cell. The NH4+ ion generates medium to strong hydrogen bonds with the carbonylic oxygen, the iminic nitrogen and the sulfonyl oxygen atoms of the acesulfamate anion. The FTIR spectrum of the compound was also recorded and is briefly discussed.","palabras_clave":"Ammonium acesulfamate|Synthesis|Crystal structure|FTIR-spectra"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39714,"idioma_id":4,"titulo":"When the periphery becomes the center: Forensic Anthropology in Argentina, a case of socially relevant scientific knowledge production","resumen":"Forensic anthropology has had an extraordinary scientific success in Argentina. On the one hand, this discipline has developed very well for short 25 years generating scientifically relevant knowledge both locally and internationally. On the other hand, and unlike a large part of scientific knowledge generated in peripheral contexts, it has major social applications. This work describes the different dimensions of the origin and development of this discipline in Argentina. The cognitive condition of that science in 1983 and, briefly, its development until today, its institutional dimension, the existence of other research traditions and some social dimensions which, we believe, are the basis for the success of this scientific discipline.","palabras_clave":"Forensic Anthropology|Sociology of science"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39715,"idioma_id":4,"titulo":"Interaction effects on  galaxy pairs  with Gemini\/GMOS- I: Electron density","resumen":"We present an observational study about the impacts of the interactions on the electron density of HII regions located in seven systems of interacting galaxies. The data consist of long-slit spectra in the range 4400-7300 A, obtained with the Gemini Multi-Object Spectrograph at Gemini South (GMOS-S). The electron density was determined using the ratio of emission-lines [S II] lambda 6716\/ lambda 6731. Our results indicate that the electron density estimates obtained of HII regions from our sample of interacting galaxies are systematically higher than those derived for isolated galaxies. The mean electron density values of interacting galaxies are in the range of Ne = 24 - 532 cm^{-3}, whilethose obtained for isolated galaxies are in the range of Ne = 40 - 137 cm^{-3}. Comparing the observed emission lines with predictions of photoionization models, we verified that almost all the HII regions of the galaxies AM1054A, AM2058B, AM2306B have emission lines excited by shocks, such as in AM2322B (one point) and AM 2322A (four points). No correlation is obtained between the presence of shocks and electron densities. Indeed, the highest electron density values found in our sample do not belong to the objects with gas shock excitation. We emphasize the importance of considering theses quantities especially when the metallicity is derived for this type of systems.","palabras_clave":"galaxies: ISM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39716,"idioma_id":5,"titulo":"Seroprevalencia y estudio de factores asociados a  la neosporosis canina en animales ingresados al Hospital Escuela, FCV,  UBA, Argentina","resumen":"El análisis de riesgo (AR) es una herramienta que facilita la toma de decisiones, proporcionando información sobre el riesgo de introducción de agentes que afecten negativamente la salud, a través del comercio de animales, productos y subproductos de origen animal. Si bien no es una metodología nueva (se ha utilizado en diversas áreas como ingeniería y economía), su aplicación en el ámbito de la salud animal es relativamente reciente. La creciente globalización de los intercambios comerciales de animales y\/o productos derivados de estos incrementan las posibilidades de diseminación de enfermedades. Ante esta situación, es necesario establecer mecanismos que permitan el comercio, protegiendo la salud de las poblaciones y el ambiente de los países involucrados. Una parte importante del proceso de análisis de riesgo es la transparencia, por lo que es fundamental que se utilice una nomenclatura y una metodología estandarizadas que permitan a todos los actores involucrados entender el análisis realizado, sus consecuencias y las recomendaciones por seguir.","palabras_clave":"NEOSPORA CANINUM|SEROPREVALENCIA|FACTORES|CANINOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39717,"idioma_id":4,"titulo":"Freeze Dried Bone Matrix on Rat Critical Size Defect Regeneration","resumen":"Abstract: Bone allografts are commonly used for bone regeneration. The aim of this study was evaluate the efficacy of a freeze dried bone matrix (FDBM) in critical size defect (CZD) rat calvaria. Eighteen Wistar female rats (body weight 150 ± 50 g) with CZD (5mm) were divided in two groups: group 1, using freeze dried bone matrix; and group 2, only with coagulum. All samples were evaluated on the 1st, 3rd and 6th weeks post-surgery by soft X-ray, histological and histometric studies. Soft X-ray results showed a radiolucent image with many irregular radiopaque areas. Histologically, bone regeneration was initiated from the 3rd week, when a thin layer of new woven bone could be seen adjacent to the matrix. At the 6th week, lamellar bone covered over half (61.8 %) of the defect area. The lack of FDBM resorption allowed its incorporation to the new regenerated bone. This behavior is important in circumstances where it is necessary not only to stimulate bone regeneration but also increase the volume in affected areas, such as during the placement of dental implants. The results obtained in this research are encouraging for the use of freeze dried bone matrix as a bone graft material.Key words:  Freeze dried bone, Critical-sized defect, Bone regeneration","palabras_clave":"freeze dried bone|critical size defect|bone regeneration"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39718,"idioma_id":4,"titulo":"Novel antifungal agents: a patent review (2011 - present)","resumen":"Introduction: Invasive fungal infections (IFI) have increased significantly over the past decades. The mortality rate of IFI is alarming, and early and accurate diagnosis is difficult. Most used antifungal drugs are not completely effective due to the development of increasing resistance and undesirable side effects which limit their use. In this scenario, new effective broad spectrum and safer antifungal drugs are urgently needed.  Areas covered: This review summarizes the latest advances in the discovery of new antifungal compounds through the patents granted from 2011 to August 2013. In the 26 patents reviewed here, either derivatives of existing antifungal drugs or novel structures are included. New imidazoles, fluconazole analogs and adducts of azoles with 2,6-di-tert-butyl-4-methylphenol are described. The review also includes chitinases, b-1,3-D-glucan and chitin synthases inhibitors and novel structures.  Expert opinion: In the patents reviewed here, progress has been made to accomplish at least one of the necessary requirements for the development of novel antifungal agents, such as broad spectrum of activity, more favorable pharmacokinetic profile, good bioavailability and low adverse effects. However, in vivo activity, mechanisms of action, drug--drug interactions and other aspects that make a compound a good antifungal agent need further development.","palabras_clave":"ANTIFUNGAL COMPOUND|AZOLE|DRUG RESISTANCE|ECHINOCANDINS|ERGOSTEROL BIOSYNTHESIS INHIBITION|FUNGAL CELL WALL|FUNGAL MEMBRANE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39719,"idioma_id":4,"titulo":"Methanol and ethanol oxidation on carbon supported nanostructured Cu core Pt-Pd shell electrocatalysts synthesized via redox displacement","resumen":"Six different carbon-supported Cu core Pt-Pd shell (Cu@Pt-Pd) catalysts have been successfullysynthesized by the galvanic replacement of Cu atoms by Pt4+ and Pd2+ ions atroom temperature and their electrocatalytic activity for methanol and ethanol oxidationhave been evaluated in acid media. Cu@Pt-Pd core shell nanoparticles with a narrow sizedistribution and an average diameter in the range of 3.1-3.5 nm were generated onto thecarbon support. The compositional and the structural analysis of the as-prepared materialspointed out that the nanoparticles are formed by a Cu rich core covered by a Pt-Pd richshell due to the interdiffusion of the metals after the galvanic replacement reaction. Theelectrocatalytic properties of the Cu@Pt-Pd electrodes in the electro-oxidation of methanoland ethanol was found to be dependent on the electrochemical surface area, lattice strainof the surface, composition and thickness of the Pt-Pd shell surrounding the Cu core. Theoptimum catalyst composition to obtain the best performance for methanol and ethanolelectro-oxidation was determined to be Pt0.59-Pd-0.324-Cu0.167\/C (6.2 wt.% Pt, 2.2 wt.% Pd and0.7 wt.% Cu). This catalyst has a greatly enhanced mass activity, lower onset potential andpoisoning rate, and higher turnover number in the MOR and EOR reactions compared to acommercial Pt0.51-Ru0.49\/C (20 wt.% Pt and 10 wt.% Ru). Consequently, this simple preparationmethod is a viable approach to making a highly active catalyst with low platinumcontent for application in direct alcohol fuel cells (DAFCs).","palabras_clave":"Core-shell |Pt-Pd-Cu supported catalysts |Methanol and Ethanol |fuel cells"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39720,"idioma_id":4,"titulo":"New contributions to non-linear process monitoring through kernel partial least squares","resumen":"The kernel partial least squares (KPLS) method was originally focused on   soft-sensor calibration for predicting online quality attributes. In   this work, an analysis of the KPLS-based modeling technique and its   application to nonlinear process monitoring are presented. To this   effect, the measurement decomposition, the development of new specific   statistics acting on non-overlapped domains, and the contribution   analysis are addressed for purposes of fault detection, diagnosis, and   prediction risk assessment. Some practical insights for synthesizing the   models are also given, which are related to an appropriate order   selection and the adoption of the kernel function parameter. A proper   combination of scaled statistics allows the definition of an efficient   detection index for monitoring a nonlinear process. The effectiveness of   the proposed methods is confirmed by using simulation examples.","palabras_clave":"KPLS MODELING|FAULT DETECTION|FAULT DIAGNOSIS|PREDICTION RISK ASSESTMENTS|NONLINEAR PROCESSES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39721,"idioma_id":4,"titulo":"Dendritic cells regulate angiogenesis associated with liver fibrogenesis","resumen":"During liver fibrogenesis the immune response and angiogenesis process are fine-tuned resulting in activation of hepatic stellate cells that produce an excess of extracellular matrix proteins. Dendritic cells (DC) play a central role modulating the liver immunity and have recently been implicated to favour fibrosis regression; although their ability to influence the development of fibrogenesis is unknown. Therefore, we explored whether the depletion of DC during early stages of liver injury has an impact in the development of fibrogenesis. Using the CD11c.DTR transgenic mice, DC were depleted in two experimental models of fibrosis in vivo. The effect of antiangiogenic therapy was tested during early stages of liver fibrogenesis. DC depletion accelerates the development of fibrosis and as a consequence, the angiogenesis process isboosted.Weobserved up-regulation of pro-angiogenic factors together with an enhanced vascular endothelial growth factor (VEGF) bioavailability, mainly evidenced by the decrease of anti-angiogenic VEGF receptor 1 (also known as sFlt-1) levels. Interestingly, fibrogenesis process enhanced the expression of Flt-1 on hepaticDCand administration of sFlt-1 was sufficient to abrogate the acceleration of fibrogenesis upon DC depletion. Thus, DC emerge as novel players during the development of liver fibrosis regulating the angiogenesis process and thereby influencing fibrogenesis.","palabras_clave":"dendritic cells|angiogenesis|liver fibrogenesis|sFlt-1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39722,"idioma_id":4,"titulo":"THE COMPLETE GENOME OF A PUTATIVE ENDORNAVIRUS IDENTIFIED IN YERBA MATE (ILEX PARAGUARIENSIS ST. HIL.)","resumen":"We present the first report of a virus infecting the subtropical tree crop yerba mate (Ilex paraguariensis St. Hil.). Total RNA purification, followed by next-generation sequencing, transcripts assembly and annotation, resulted in the identification of a new endornavirus species infecting yerba mate. The complete sequence of the linear dsRNA viral genome is 13954 nt long, contains a single 13743 nt ORF, presents a 149 nt 5´UTR and a 61 nt 3´UTR. The predicted ORF encodes a 4581 aa polypeptide with a UDP-glucose glycosyl-transferase, a capsular polysaccharide synthesis protein and a RNA dependent RNA polymerase domain. The name yerba mate endornavirus (YmEV) is proposed for the identified virus. Due to the intriguing peculiarities of this virus family, and the complete lack of yerba mate virus literature, we consider that the information reported here will be helpful in leading to a new and needed attention to this important topic and crop.","palabras_clave":"Yerba mate|Endornavirus|Virus genome|Phylogenetic analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39723,"idioma_id":4,"titulo":"Invasive belowground mutualists of woody plants","resumen":"Most plants require mutualistic associa-  tions to survive, which can be an important limitation  on their ability to become invasive. There are four  strategies that permit plants to become invasive   without being limited by a lack of mutualists. One is   to not be dependent on mutualists. The other three   strategies are to form novel mutualisms, form associ-   ations with cosmopolitan species, or co-invade with   mutualists from their native range. Historically there   has been a bias to study mutualisms from a plant   perspective, with little consideration of soil biota as   invasive species in their own right. Here we address   this by reviewing the literature on belowground   invasive mutualists of woody plants. We focus on   woody invaders as ecosystem-transforming plants that   frequently have a high dependence on belowground   mutualists. We found that co-invasions are common,  with many ectomycorrhizal plant species and N-fixing   species co-invading with their mutualists. Other   groups, such as arbuscular mycorrhizal plants, tend   to associate with cosmopolitan fungal species or to   form novel associations in their exotic range. Only   limited evidence exists of direct negative effects of co-   invading mutualists on native mutualist communities,   and effects on native plants appear to be largely driven   by altered environmental conditions rather than direct   interactions. Mutualists that introduce novel ecosys-   tem functions have effects greater than would be   predicted based solely on their biomass. Focusing on   the belowground aspects of plant invasions provides   novel insights into the impacts, processes and man-   agement of invasions of both soil organisms and   woody plant species.","palabras_clave":"N\/A"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39724,"idioma_id":5,"titulo":"Caracterización y situación actual de los Bosques Nativos en el Centro Sur de la Provincia de Córdoba, Argentina.","resumen":"Caracterización y situación actual de los bosques nativos en el centro sur de la provincia de Córdoba, Argentina.","palabras_clave":"CONSERVACIÓN|BOSQUES NATIVOS|CÓRDOBA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39725,"idioma_id":4,"titulo":"Activity of a novel compound produced by Aspergillus parasiticus  in the presence of red flour beetle Tribolium castaneum against  Pseudomonas aeruginosa and coleopteran insects","resumen":"Aspergillus is a promising source of bioactive secondary metabolites. The addition of insect-derived material in the broth culture could trigger the biosynthesis of insecticidal and antimicrobial compounds by entomopathogenic fungus (EF). Insects inhabit diverse niches and interact with various bacteria, for this reason, when a fungus kills an insect should inhibit the insect?s gut bacteria to prevent the insect consumptionby bacteria. According with this hypothesis, the EF is able to produce substances that inhibit bacteria growth or bacteria virulence strategies. In the present, investigation is demonstrated that the addition of Tribolium castaneum Herbst (Coleoptera: Tenebrionidae) components (2 % w\/v) in a culture of saprophytic fungus Aspergillus parasiticus MOR 3 induces the production of a novel compound present inside mycelium 2-(4-bromophenyl)-2-oxoethyl benzoate, that is reported here for the first time as a natural product of A. parasiticus. In addition, increased significantly the fungal extracellular production of undecyl 4-fluorobenzoate. The mycelium extract (ME) at 250 ìg per g of diet on adult population of T. castaneum produced an alteration of the feeding behavior of coleopteran insects (Repellency index = +30). The fraction derived from ME (Fr2) that contained the organobromine compound, 2-(4-bromophenyl)-2-oxoethylbenzoate had the highest inhibition of the Pseudomonas aeruginosa virulence factors like elastase enzyme (49 %) at 5 ìg\/ml and biofilm formation (43 %) at 100 ìg\/ml. The results suggest that the extract from mycelium of a non-aflatoxigenic A. parasiticus MOR 3 strain is a potential candidate as food coleopteran repellent as well as an anti-virulence strategy of P. aeruginosa. ","palabras_clave":"ASPERGILLUS PARASITICUS|FUNGAL INDUCTION|REPELLENT SUBSTANCES|TRIBOLIUM CASTANEUM HERBST|PSEUDOMONAS AERUGINOSA|BIOFILM|ELASTASE ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39726,"idioma_id":4,"titulo":"Binding of [Cr(phen)3]3+ to transferrin at extracellular and endosomal pHs: Potential application in photodynamic therapy","resumen":"Background: Transferrin is an iron-binding blood plasma glycoprotein that controls the level of free iron in biologicalfluids. This protein has been deeply studied in the past few years because of its potential use as a strategy ofdrug targeting to tumor tissues. Chromium complex, [Cr(phen)3]3+ (phen = 1,10-phenanthroline), has beenproposed as photosensitizers for photodynamic therapy (PDT). Thus, we analyzed the binding of chromiumcomplex, [Cr(phen)3]3+, to transferrin for a potential delivery of this diimine complex to tumor cells for PDT.Methods: The interaction between [Cr(phen)3]3+ and holotransferrin (holoTf) was studied by fluorescencequenching technique, circular dichroism (CD) and ultraviolet (UV)?visible spectroscopy.Results: [Cr(phen)3]3+ binds strongly to holoTfwith a binding constant around 105M&#8722;1, that depends on the pH.The thermodynamic parameters indicated that hydrophobic interactions played amajor role in the binding processes.The CD studies showed that there are no conformational changes in the secondary and tertiary structuresof the protein.Conclusions: These results suggest that the binding process would occur in a site different from the specific ironbinding sites of the protein and would be the same in both protein states. As secondary and tertiary structures oftransferrin do not showremarkable changes, we propose that the TfR could recognize the holoTf despite having achromium complex associated.General significance: Understanding the interaction between [Cr(phen)3]3+ with transferrin is relevant becausethis protein could be a delivery agent of Cr(III) complex to tumor cells. This can allow us to understand furtherthe role of Cr(III) complex as sensitizer in PDT.","palabras_clave":"Tris(1,10-phenanthroline)chromium(III)|Apotransferrin|Holotransferrin|Photodynamic therapy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39727,"idioma_id":4,"titulo":"The modulatory action of Allopregnanolona on  hypothalamic  3beta-HSD modifies the ovarian steroidogenesis in female rat.","resumen":"Vega Orozco y Laconi: Both authors contribute equally.  Abstract  The aims of this work were to study: whether icv in vivo allopregnanolone injection modifies the  enzymatic activity and gene expression of the 3&#946;-hydroxysteroid- dehydrogenase (3&#946;-HSD) in  hypothalamus and ovary and if exist an modulatory effect of allopregnanolone on the peripheral  nervous system that regulate ovarian steroidogenesis on proestrus (PE) and dioestrus I (DI) day.  In the in vivo experiments, on PE, allopregnanolone caused a decrease in the 3&#946;-HSD activity in  hypothalamus and ovary but did not show changes in gene expression. On DI, allopregnanolone  caused an increase on the 3&#946;-HSD activity and gene expression in the ovary without changes in  the hypothalamus.  In the ex vivo experiment, the SMG-ONP-Ovary system was isolated after the drugs injection and  ovarian progesterone concentration was determined at different times. The ovarian progesterone  release and the 3&#946;-HSD activity augmented on PE and DI. The gene expression of ovarian 3&#946;-  HSD increased only during DI. These effects were reverted by bicuculline in both stages in all  experiments. Allopregnanolone has a modulatory effect on the hypothalamic and ovarian  steroidogenesis in the time and cycle-depending pathway mediated by both peripheral nervous  system and hypothalamic GABAergic system.","palabras_clave":"ALLOPREGNANOLONE|HYPOTHALAMUS|OVARY|HYDROXYSTEROID DEHYDROGENASE |STEROIDOGENES|PERIPHERAL NERVOUS SYSTEM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39728,"idioma_id":4,"titulo":"Large-scale fungal diversity assessment in the Andean Yungas forests reveals strong community turnover among forest types along an altitudinal gradient","resumen":"The Yungas, a system of tropical and subtropical montane forests on the eastern slopes of the Andes, are extremely diverse and severely threatened by anthropogenic pressure and climate change. Previous mycological works focused on macrofungi (e.g. agarics, polypores) and mycorrhizae in Alnus acuminata forests, while fungal diversity in other parts of the Yungas has remained mostly unexplored. We carried out Ion Torrent sequencing of ITS2 rDNA from soil samples taken at 24 sites along the entire latitudinal extent of the Yungas in Argentina. The sampled sites represent the three altitudinal forest types: the piedmont (400?700&nbsp;m a.s.l.), montane (700?1500&nbsp;m a.s.l.) and montane cloud (1500?3000&nbsp;m a.s.l.) forests. The deep sequence data presented here (i.e. 4&nbsp;108&nbsp;126 quality-filtered sequences) indicate that fungal community composition correlates most strongly with elevation, with many fungi showing preference for a certain altitudinal forest type. For example, ectomycorrhizal and root endophytic fungi were most diverse in the montane cloud forests, particularly at sites dominated by Alnus acuminata, while the diversity values of various saprobic groups were highest at lower elevations. Despite the strong altitudinal community turnover, fungal diversity was comparable across the different zonal forest types. Besides elevation, soil pH, N, P, and organic matter contents correlated with fungal community structure as well, although most of these variables were co-correlated with elevation. Our data provide an unprecedented insight into the high diversity and spatial distribution of fungi in the Yungas forests.","palabras_clave":"BIODIVERSITY|FUNGI|ION TORRENT SEQUENCING|METABARCODING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39729,"idioma_id":5,"titulo":"El reino Plantae: ¿Qué es una planta y cómo se clasifican?: Un cambio paradigmático","resumen":"Hoy en día existe un cambio de paradigmas en la Botánica, que es fundamental analizar y debatir. Los principales conceptos que están bajo una intensa discusión y cambios son la filogenia y clasificación biológica de los seres vivos con cloroplastos, la nueva visión del concepto de ?planta? y ?célula vegetal? y el reemplazo de la teoría celular por una visión organísmica de las plantas pluricelulares, lo que ha generado una visión holística de las mismas. Los objetivos del presente trabajo son presentar y debatir la actual circunscripción de los conceptos de ?planta? y ?célula vegetal? y presentar los recientes cambios en el campo de la filogenia y clasificación de las plantas","palabras_clave":"TEORÍA CELULAR|TEORÍA ORGANISMICA|CÉLULA VEGETAL|FILOGENIA DE PLANTAS|REINO PLANTAE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39731,"idioma_id":4,"titulo":"Self-Optimizing Control Structures with Minimum Number of Process-Dependent Controlled Variables","resumen":"In order to operate continuous processes near the economically optimal steady-state operating point, self-optimizing control schemes reformulate the optimization problem as a process control problem. The objective is to find controlled variables and constant set points such that the controller leads to optimal adjustments of the inputs in the presence of stable disturbances. In particular, the null space approach consists in selecting the self-optimizing controlled variables as linear combinations of the inactive output variables, based on the first-order variation of the necessary conditions of optimality. In the self-optimizing control structures proposed in the literature, the number of controlled variables required is typically equal to the number of degrees of freedom (inputs) that are available after all the equality and active inequality constrained variables are controlled. In this paper, we propose new self-optimizing control structures based on the null space approach, where depending on the number of disturbances, the number of active constraints, and the number of inputs, it is possible to decrease the number of process-dependent controlled variables by fixing linear combinations of the inputs. The effectiveness of the proposed self-optimizing control structures with minimum number of process-dependent controlled variables is demonstrated in simulation by means of a continuous stirred tank reactor and an evaporator.","palabras_clave":"SELF-OPTIMIZING CONTROL|NULL-SPACE METHOD|MINIMUM NUMBER OF CONTROL LOOPS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39732,"idioma_id":4,"titulo":"Effects of Different Water Deprivation Levels on Arbuscular Mycorrhizae Fungi Associated with Olives Trees","resumen":"Olive trees have a great adaptability to adverse soil conditions and are typically grown in marginal soils with low fertility. Water deficit and osmotic  imbalance are the most common stressors affecting crops in arid and semi-arid  regions. Tolerance to osmotic stress in plants is a complex phenomenon that  involves many changes at the biochemical and physiological levels. However, the  mechanisms behind the modulation of tissue water conductivity and osmotic  adjustment appear to be affected by arbuscular mycorrhizal fungi (AMF). This study aims to evaluate the effect of water availability on the AMF (colonization  and spores) of olive trees (cv. Arbequina) grown in two different agro-climatic  environments. The experimental design included two  water deficit treatments, one at 50% of the estimated crop evapotranspiration in  the province of Mendoza  and a second one under natural rainfall conditions in the province of Córdoba,  and in each locality two adjacent treatments irrigated at 100% of the estimated  crop evapotranspiration. The root-associated soil samples from each individual  plant (n=10) were randomly collected between 10 to 20 cm depth. Each sample  consisted of five bulked sub-samples (200 cm3 soil cores). From each  soil sample, olive roots were extracted, stained and their AMF structures determined.  The total AMF spore number was also quantified. The arbuscular mycorrhizal colonization  (AMC) rate was higher in treatments with less water availability; the average  increments were found to be 42% and 75% for Mendoza and Córdoba, respectively  (p &#8804; 0.01). The same pattern was found in AMF spore number; 42% for Mendoza and 121% for Córdoba  (p &#8804; 0.01). These results indicate that treatments with less irrigation seem to  stimulate AMC and spore production. Further studies are needed in order to determine  if AMF allows olive tree roots to access the soil  water reservoir.","palabras_clave":"ARBUSCULAR MYCORRHIZAL SYMBIOSIS|OLIVE TREE|WATER RELATIONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39733,"idioma_id":5,"titulo":"Interfaz visual para un Autocolimador Nikon 6D mediante procesamiento de imagenes con precision sub-pixel: un caso de estudio","resumen":"Este documento tiene el objetivo de describir el potencial de una interfaz visual basica en un Autocolimador del tipo Nikon 6B\/6D, para reemplazar al operario en una medici´on de calidad metrologica. La interfaz visual implementada consta de una camara con sensor CMOS adosada al ocular del autocolimador, partes posicionales, y un sistema de procesamiento digital de imagenes  propio, escrito en lenguaje Matlab , que analiza la imagen de la ret&#305;cula para detectar la escala y la cruz de medicion a nivel sub-p&#305;xel. Mediante un experimento controlado, realizado con un nivel electronico trazable internacionalmente, se obtuvieron, con este sistema, angulos de cabeceo (\u000By) con una resolucion tres veces mejor que la del instrumento sin interfaz. Este ejemplo sugiere que el valor de 0.06 p&#305;xeles para la incertidumbre asociada con la posicion sub-p&#305;xel de las diferentes l&#305;neas que conforman la ret&#305;cula de medicion es realista, y permite seguir trabajando en una interfaz robusta para todos los parametros angulares posibles deser medidos por el autocolimador.","palabras_clave":"autocolimador visual|interfaz electronica|reconocimiento de lineas|procesamiento subpixel"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39734,"idioma_id":4,"titulo":"The bacterial community structure of hydrocarbon-polluted marine environments as the basis for the definition of an ecological index of hydrocarbon exposure","resumen":"Using amplicon pyrosequencing of 16S  rRNA genes, we analyzed the bacterial community structure of intertidal  sediments from two sites of the Patagonian coast with a different history of hydrocarbon  exposure, using a global and a local perspective. Global-scale patterns in  bacterial community structure seemed to be mostly associated with environmental  factors such as sediment depth and distance from the coast, while the effect of  hydrocarbon exposure was not noticeable. However, at a local scale, differences  in community composition between samples with different hydrocarbon content  could be detected at the class level, including higher abundances of  Gammaproteobacteria and Alphaproteobacteria in polluted samples. These differences  were more noticeable at the genus level, indicating that phylogenetic  resolution is a factor to take into account when analyzing local differences in  bacterial communities. Considering 63 bacterial genera selected based on being previously  linked to hydrocarbon biodegradation, 40% of them showed higher abundances in  at least one of the polluted samples with respect to the pristine sample. Using  this information, an ecological indicator (ecological index of hydrocarbon  exposure, EIHE) was defined and calculated for these samples, as well as for  samples from a previous study. The EIHE index is directly related to the  proportion of the bacterial community potentially capable of hydrocarbon biodegradation,  and therefore can provide an estimation of hydrocarbon-degrading potential of  the microbial community and of hydrocarbon exposure history. This index could  be a valuable tool for bioremediation technologies, as a high number of samples  can be processed and analyzed in a semi-automated manner.","palabras_clave":"HYDROCARBON POLLUTION|COASTAL MARINE ENVIRONMENTS|BACTERIAL COMMUNITY STRUCTURE|PYROSEQUENCING|ECOLOGICAL INDICATORS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39735,"idioma_id":4,"titulo":"Biomarkers of environmental stress in gills of ribbed mussel Aulacomya atra atra (Nuevo Gulf, Northern Patagonia)","resumen":"In this study, we assessed in gills of native ribbed mussels Aulacomya atra atra from three sites within Nuevo Gulf (Northern Patagonia)several biomarkers such as reactive oxygen species(ROS),lipid radicals (LR), malondialdehyde (MDA),superoxide dismutase (SOD),catalase (CAT),glutathione S-transferase (GST) and metallothionein(MT).Furthermore, concentrations of main trace metals (Fe,Al,Zn,Cu,Cd and Pb) were quantified in mussel tissue. Results showed significant induction of SOD, GST, MT and MDA, as well as, higher concentration of Fe, Al and Cd in winter than in summer. The high MDA content measured in mussels from Folías Wreck seemed to be caused by the very high levels of Fe that would come from the corrosion of the vessel. Mussels from the control site Punta Cuevas presented the lowest levels of Cd and the highest of Al in winter. Despite positive correlations were found between Al and GST and MT, no spatial differentiation was detected in those biomarkers. On the other hand, MT was only related to Al been most likely influenced by environmental variables than by the trace metals. It has to be highlighted that the relationship detected among water temperature, nutrients and antioxidant responses in gills is probably related to the fact that this tissue is in direct contact with water and it is sensitive to its fluctuations. Taking into account that mussel gill is a tissue actively proliferating and the first target of contaminants present in water, so that changes in its antioxidant system can provide an earlier warning signal than in other tissues.","palabras_clave":"Biomarkers|Trace metals|Oxidative stress|Gills"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39736,"idioma_id":4,"titulo":"Finite-dimensional Pointed or Copointed Hopf algebras over affine racks","resumen":"We study the copointed, respectively pointed, liftings of Nichols algebras associated toaffine racks and constant cocycle over k^G, respectively kG, for any finite groupG admitting a principal YD-realization of the rack. In the copointed case we completethe classification for the four affine racks whose Nichols algebra is known to be offinite dimension. In the pointed case our method allows us to finishthree of them. In all of the cases the Hopf algebras obtained turn out to be cocycledeformations of their associated graded Hopf algebras. All of them are new examples offinite-dimensional copointed or pointed Hopf algebras over non-abelian groups.","palabras_clave":"HOPF ALGEBRAS|POINTED HOPF ALGEBRAS|COPOINTED HOPF ALGEBRAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39737,"idioma_id":4,"titulo":"'Detection transposable elements in Botrytis cinerea in latent infection stage from symptomless apples'","resumen":"Detection of Botrytis cinerea latent infections on apples before storage is essential for effective control strategies in the fruit postharvest industry. In the present study a PCR detection method, based on primers designed on B. cinerea transposable elements (boty and flipper) and  intergenic spacer (IGS) region as internal control were utilized to reveal the presence of symptomless infections on apple fruits. The method molecular proved to be highly specific and sensitive in detecting latent infections, revealed the presence of the pathogen in 83% of the samples from infected apples with 104 conidia\/mL, whereas those infected with 106 conidia\/mL detected 94% as compared to the traditional method that revealed the pathogen in 40 and 66% of the samples inoculated with 104 and 106 conidia\/mL respectively. Furthermore, the method characterized B. cinerea as subpopulation transposa-type by the presence of the transposable elements boty and flipper  The results obtained of DNA quantification method were compared with ELISA assay and these studies showed good correlation. Therefore our method has important advantages compared with others detection methods for B. cinerea, because the proposed methodology allowed distinguishes between its two subpopulations (vacuma and transposa) and this would allow establish possible control appropriate strategies. Finally, the method can be an interesting alternative for its possible application in the phytosanitary programs of the fruit industry worldwide.","palabras_clave":"BOTRYTIS CINEREA|LATENT INFECTION|TRANSPOSABLE ELEMENTS|SYMPTOMLESS APPLES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39738,"idioma_id":5,"titulo":"Entre Saberes Académicos y Saberes Populares: La Escuela Primaria Popular","resumen":"En el presente trabajo nos proponemos compartir reflexiones y posicionamientosteÉrico\/ ideolÉgicos que surgen al calor de nuestra experiencia como educadorasPopulares en un espacio singular, como lo es los procesos de EducciÉn de Adultos.En San Luis, segÑn diversos estudios realizados, casi el 20% de la poblaciÉn no haterminado su escolarizaciÉn o nunca asistiÉ a la escuela. Ello nos convocÉ a ofrecer a losjÉvenes y Adultos de sectores populares un espacio en donde pudieran, desde los saberespropios de sus contexto de origen, acceder a los saberes mÖs sistemÖticos que los y lashabilitara para ir concretando su escolaridad y que denominamos ?Escuela PrimariaPopular?.Articular lÉgicas de producciÉn de conocimiento histÉricamente fragmentadas, nosenfrentÉ a un complejo proceso de bÑsquedas, discusiones y debates que nos permitieranconstruir un horizonte polàtico de emancipaciÉn a los saberes escolarizados. De allà quedaremos cuenta de las mUltiples tensiones por las que vamos atravesando en este sentidoy que interpelan cotidianamente nuestras prÖcticas como educadores, al mismo tiempoque vamos redefiniendo el sentido de la ?extensiÉn Universitaria? en los espaciosmarcados por la pobreza.Las voces de los y las sujetos participantes encarnadas en las vivencias en torno a estaexperiencia, son las que nos devuelven la mirada acerca de lo que debemos hacer, sentir,pensar cuando optamos por trabajar junto con los sectores populares.","palabras_clave":"SECTORES POPULARES|ESCUELA PRIMARIA|SABERES ACADEMICOS Y POPULARES|EXTENSION UNIVERSITARIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39739,"idioma_id":4,"titulo":"A note on the homotopy type of the Alexander dual","resumen":"We investigate the homotopy type of the Alexander dual of a simplicial complex. It is known that in general the homotopy type of $K$ does not determine the homotopy type of its dual $K^*$. We construct for each finitely presented group $G$, a simply connected simplicial complex $K$ such that $pi_1(K^*)=G$ and study sufficient conditions on $K$ for $K^*$ to have the homotopy type of a sphere. We extend the simplicial Alexander duality to the more general context of reduced lattices and relate this construction with Bier spheres using deleted joins of lattices. Finally we introduce an alternative dual, in the context of reduced lattices, with the same homotopy type as the Alexander dual but smaller and simpler to compute.","palabras_clave":"dualidad alexander|complejos simpliciales|homologia|lattice"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39740,"idioma_id":4,"titulo":"Reactivation of Paleozoic structures during Cenozoic deformation in the Cordón del Plata and Southern Precordillera ranges (Mendoza, Argentina)","resumen":"The tectonic style of the eastern morphostructural units of the Central Andes between 32°20´ and 33°20´S is strongly influenced by pre-Andean structures, especially those developed during the late Carboniferous-Early Permian San Rafael orogeny of the Gondwanan orogenic cycle. Moreover, in the study area pre-Carboniferous rocks were deformed in Late Devonian-early Carboniferous times by the Chanic orogeny. In this paper we argue that the Cordón del Plata and the Southern Precordillera ranges, first order features of the eastern ranges of the Andes, have been shaped in large part by the Permian event. Our data suggest that the double verging character of the Andean Precordillera fold- thrust belt is mainly the result of the reactivation of Gondwanan structures which conform a fold-thrust belt with distinct characteristics north and south of 33°S.  The northern sector of this belt corresponds to a bivergent system, while the southern sector had a widespread east vergence. The vergence of the Chanic structures is more difficult to determine, but we infer a westward vergence in the Frontal Cordillera and western sector of Precordillera, and an eastern vergence in the eastern sector of the Precordillera. The sharp disappearance of the Precordillera morphostructural unit south of 33°S is inferred here to be related to the distribution of inherited Permian structures.","palabras_clave":"ANDES CENTRALES DEL SUR|REACTIVACIÓN TECTÓNICA|FAJA PLEGADA Y CORRIDA PÉRMICA|FRENTE DE DEFORMACIÓN ANDINO|ORÓGENO CHÁNICO|CORDILLERA FRONTAL|PRECORDILLERA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39742,"idioma_id":4,"titulo":"Effects of the synthetic estrogen 17&#945;- Ethinylestradiol on aromatase expression, reproductive behavior and sperm quality in the fish Jenynsia multidentata","resumen":"The synthetic estrogen 17a-ethynylestradiol(EE2) has been increasingly detected in sewage effluents inthe last two decades. The aim of the present study wasdetermined if EE2 exposure adversely affected reproductionin internally fertilizing fish species Jenynsia multidentata.Sexual behavior, brain and gonadal aromataseexpression as well as sperm quality were evaluated. Thebrain aromatase expression, reproductive behavior, spermatozoaviability and gonadosomatic index were sensitivebiomarkers of EE2 effects on this species. The conditionfactor, hepatosomatic index, gonadal aromatase expression,sperm count and sperm velocities were unaltered after EE2exposure. The present work highlights the importance ofusing a combination of several biomarkers to study theeffects of estrogenic compounds, especially when trying tolink these results to potential population-level effects.","palabras_clave":"ESTROGENS|ENDOCRINE DISRUPTORS|FISH|WATER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39743,"idioma_id":4,"titulo":"Effect of fasting in the digestive system: Histological study of the small intestine in house sparrows","resumen":"In birds and mammals the metabolic response to fasting has been studied and can be characterized by three consecutive phases reflecting metabolic and physiological adjustments. An effective way to minimize energy expenditure during food scarcity is to decrease the mass of the organs. As the digestive system is metabolically expensive to maintain, the small intestine and the liver are the most affected organs. We evaluated the effects of phase III starvation on the mass of the different organs and histological parameters on house sparrows, a small non-migrant bird. In a short period of time (34 hours) we observed a larger reduction in the digestive organ mass when compared to the mass of the body and non-alimentary tissues. Furthermore, the intestinal mass was proportionally more reduced than its length and nominal surface area. A reduction on the intestinal mucosal layer also resulted in a shortening of villus (length and thickness) and crypt depth. Moreover, the morphology of the enterocytes changed from cylindrical to cubical, suggesting that the surface exposed to the lumen was conserved. This may indicate an adaptive response to the moment of refeeding. The nominal surface area\/body mass remained constant in both groups and several histological parameters were reduced, suggesting that starving induces the atrophy of the small intestine. However, the goblet cells were conserved after fasting indicating a protective tendency.","palabras_clave":"BIRDS|DIGESTIVE SYSTEM|FASTING|HISTOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39744,"idioma_id":4,"titulo":"Time course of systemic oxidative stress and inflammatory response induced by an acute exposure to residual oil fly ash","resumen":"It is suggested that systemic oxidative stress and inflammation play a central role in the onset and progression of cardiovascular diseases associated with the exposure to particulate matter (PM). The aim of this work was to evaluate the time changes of systemic markers of oxidative stress and inflammation, after an acute exposure to Residual Oil Fly Ash (ROFA). Female Swiss mice were intranasally instilled with a ROFA suspension (1.0mg\/kg body weight) or saline solution, and plasma levels of oxidative damage markers [thiobarbituric acid reactive substances (TBARSs) and protein carbonyls], antioxidant status [reduced (GSH) and oxidized (GSSG) glutathione, ascorbic acid levels, and superoxide dismutase (SOD) activity], cytokines levels, and intravascular leukocyte activation were evaluated after 1, 3 or 5h of exposure. Oxidative damage to lipids and decreased GSH\/GSSG ratio were observed in ROFA-exposed mice as early as 1h. Afterwards, increased protein oxidation, decreased ascorbic acid content and SOD activity were found in this group at 3h. The onset of an adaptive response was observed at 5h after the ROFA exposure, as indicated by decreased TBARS plasma content and increased SOD activity. The observed increase in oxidative damage to plasma macromolecules, together with systemic antioxidants depletion, may be a consequence of a systemic inflammatory response triggered by the ROFA exposure, since increased TNF-&#945; and IL-6 plasma levels and polymorphonuclear leukocytes activation was found at every evaluated time point. These findings contribute to the understanding of the increase in cardiovascular morbidity and mortality, in association with environmental PM inhalation.Copyright © 2013 Elsevier Inc. All rights reserved.","palabras_clave":"Air pollution|Particulate matter|ROFA|Oxidative stress"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39745,"idioma_id":4,"titulo":"'Plastic Deformation in Nanoindentation of a BCC Metal: A New Mechanism for Prismatic Loop Formation'","resumen":"The mechanisms of deformation under a nanoindentation in tantalum, chosen as a model BCCmetal, are indentified and quantified. Molecular dynamics calculations are conducted for themonocrystal orientation [100] and indentation experiments for the three orientations [100], [110], and[111]. The evolution of plastic deformation proceeds by the initiation through nanotwins and stackingfaults, which evolve into shear dislocation loops. It is shown through a dislocation analysis that anelementary twin (3 layers) is energetically favorable for a diameter below 7.2 nm, at which point ashear loop comprised of a perfect dislocation is formed. The shear loops expand into the material bythe advance of the edge components. Simultaneously with this advance, the screw components of theloop cross slip and generate a cylindrical surface. When the opposite segments approach, theyeventually cancel by virtue of the attraction between them, forming a quasi-circular prismatic loopcomposed of edge dislocation segments. This 'lasso' like mechanism by which a shear loop transitionsto a prismatic loop is identified for the first time. The prismatic loops advance into the material alongthe &lt;111&gt; directions, transporting material away from the nucleation site. Analytical calculationssupplement the molecular dynamics and experimental observations and provide a framework for theimproved understanding of the evolution of plastic deformation under a nanoindenter. Dislocationdensities under the indenter are estimated experimentally (~1.2 x10^15 m^-2), by moleculardynamics (7x10^15 m^-2), and through an analytical calculation (2.6x10^15-1.9x10^16 m^-2).Considering the assumptions and simplifications, this agreement is considered satisfactory.","palabras_clave":"nanoindentation|dislocations|molecular dynamics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39746,"idioma_id":4,"titulo":"U-Pb detrital ages on tuffaceous and sandstone levels from a Neogene thick foreland basin of the Central Andes of Argentina","resumen":"Six tuffaceous and sandstone levels from an Andean (Mio-Pliocene) synorogenic succession were analyzed using the U-Pb LA-ICP-MS method on detrital zircons, in order to constrain maximum depositional ages and to define the basin provenance and likely connections with the volcanic history of the South-Central Andes. The detrital ages of the different samples were rather similar, ranging from ~2007 to ~5 Ma (Paleoproterozoic to Cenozoic). The pool of ages suggests reworking and detrital contribution for the studied volcaniclastics. The main detrital populations have age mode at 460 and 480 Ma (Ordovician), whereas three main Andean volcanic episodes at ~5, 13 and 21 Ma were identified. From these new data sets, a sedimentation rate of ~0.7mm\/yr would characterize the basin fill between ~13 and 5 Ma.","palabras_clave":"Detrital U-Pb zircon ages|Vinchina Basin|Miocene Andean Foreland|Provenance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39747,"idioma_id":4,"titulo":"Understanding the Role of Oxygen Vacancies in the Water Gas Shift Reaction on Ceria-Supported Platinum Catalysts","resumen":"Reducible oxides have been shown to greatly improve the activity of water gas shift (WGS) catalysts. The precise mechanism for this effect is a matter of intense debate, but the dissociation of water is generally considered to be the key step in the reaction. We present here a study of the water activation on oxygen vacancies at the support, as part of the mechanism of the WGS reaction on Pt supported on pure and gallium-doped ceria. Doping the ceria with gallium allows tuning the vacancies in the support, while maintaining constant the metal dispersion. An inverse relationship was found between the catalytic activity to WGS and the amount of oxygen vacancies. In situ time resolved X-ray diffraction, mass spectrometry and diffuse reflectance infrared spectroscopy (DRIFT) showed that the oxygen vacancy filling by water is always fast either in Pt\/CeO2 or Pt\/CeGa. DFT calculation provides molecular insights to understand the pathway of water reaction with vacancies at the of metal-oxide interface sites. Our results suggest that the activation of water molecule in the WGS mechanism is not the rate limiting step in these systems. Concentration-modulation spectroscopy in DRIFT mode under WGS reaction conditions allows the selective detection of key reaction intermediates, a monodentate formate (HCOO) and carboxylate (CO2&#61540;-) species, which clearly indicate the prevalence of an associative mechanism activated at the oxide-metal interface of the catalyst.","palabras_clave":"water gas shift|platinum|ceria|reaction mechanism|in situ spectroscopies|DRIFT|time-resolved X-ray diffraction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39748,"idioma_id":4,"titulo":"Product distribution study of the Cl-atom initiated oxidation of ethyl methyl sulfide and diethyl sulfide","resumen":"The products formed in the gas-phase reactions of Cl atoms with (CH3CH2)2S and CH3CH2SCH3 have been investigated in a large volume reactor in NOx-free air at atmospheric pressure and (298 ± 2) K using long path ?in situ? FTIR spectroscopy for the analysis. HCl, SO2 and CH3CHO were identified as the major products for both reactions. For the Cl + CH3CH2SCH3 reaction HCHO was also identified as a major product. The yields of the products obtained for the reaction of Cl with (CH3CH2)2S were (59±2) %, (52±5) % and (103±4) % for HCl, SO2 and CH3CHO, respectively. For the reaction of Cl with CH3CH2SCH3 yields of (43±5) %, (55±3) %, (58±3) % and (53±5) % were obtained for HCl, SO2, CH3CHO and HCHO, respectively. This is the first products and mechanistic studies for the gas-phase Cl-initiated oxidation of non-CH3SCH3 alkyl sulfides. Comparison with previous results for the reaction of Cl with dimethyl sulfide is made and simple atmospheric degradation mechanisms are postulated to explain the formation of the observed products.","palabras_clave":"Distribucion de productos|sulfuros|fotoreactores|FTIR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39749,"idioma_id":4,"titulo":"Neuroprotective effects of hypothermia on synaptic actin cytoskeletal changes induced by perinatal asphyxia","resumen":"Cerebral hypoxia-ischemia damages synaptic proteins, resulting in cytoskeletal alterations, protein aggregation and neuronal death. In the previous works, we have shown neuronal and synaptic changes in rat neostriatum subjected to hypoxia that leads to ubi-protein accumulation. Recently, we also showed that, changes in F-actin organization could be related to early alterations induced by hypoxia in the Central Nervous System. However, little is known about effective treatment to diminish the damage. The main aim of this work is to study the effects of birth hypothermia on the actin cytoskeleton of neostriatal post-synaptic densities (PSD) in 60 days olds rats by immunohistochemistry, photooxidation and western blot. We used 2 different protocols of hypothermia: (a) intrahypoxic hypothermia at 15°C and (b) post-hypoxia hypothermia at 32°C. Consistent with previous data at 30 days, staining with phalloidin-Alexa(488) followed by confocal microscopy analysis showed an increase of F-actin fluorescent staining in the neostriatum of hypoxic animals. Correlative photooxidation electron microscopy confirmed these observations showing an increment in the number of mushroom-shaped F-actin staining spines in neostriatal excitatory synapses in rats subjected to hypoxia. In addition, western blot revealed &#946;-actin increase in PSDs in hypoxic animals. The optic relative density measurement showed a significant difference between controls and hypoxic animals. When hypoxia was induced under hypothermic conditions, the changes observed in actin cytoskeleton were blocked. Post-hypoxic hypothermia showed similar answer but actin cytoskeleton modifications were not totally reverted as we observed at 15°C. These data suggest that the decrease of the body temperature decreases the actin modifications in dendritic spines preventing the neuronal death.","palabras_clave":"NEOESTRIATUM | PERINATAL ASPHYXIA|HYPOTEHERMIA| NEUROPROTECCION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39750,"idioma_id":4,"titulo":"Effects of Sublethal Exposure to a Glyphosate-Based Herbicide Formulation on Metabolic Activities of Different Xenobiotic-Metabolizing Enzymes in Rats","resumen":"The activities of different xenobiotic-metabolizing enzymes in liver subcellular fractions from Wistar rats exposed to a glyphosate (GLP)-based herbicide (Roundup full II) were evaluated in this work. Exposure to the herbicide triggered protective mechanismsagainst oxidative stress (increased glutathione peroxidase activity and total glutathione levels). Liver microsomes from both male and female rats exposed to the herbicide had lower (45%-54%,P&lt; 0.01) hepatic cytochrome P450 (CYP) levels compared to theirrespective control animals. In female rats, the hepatic 7-ethoxycoumarin O-deethylase (a general CYP-dependent enzyme activity) was 57% higher (P&lt; 0.05) in herbicide-exposed compared to control animals. Conversely, this enzyme activity was 58% lower (P&lt; 0.05) in male rats receiving the herbicide. Lower (P&lt; 0.05) 7-ethoxyresorufin O-deethlyase (EROD, CYP1A1\/2 dependent) and oleandomycin triacetate (TAO)N-demethylase (CYP3A dependent) enzyme activities were observed in liver microsomes from exposed male rats. Conversely, in females receiving the herbicide, EROD increased (123%-168%,P&lt; 0.05),whereas TAON-demethylase did not change. A higher (158%-179%, P&lt; 0.01) benzyloxyresorufin O-debenzylase (a CYP2Bdependent enzyme activity) activity was only observed in herbicide-exposed female rats. In herbicide-exposed rats, the hepaticS-oxidation of methimazole (flavin monooxygenase dependent) was 49% to 62% lower (P&lt; 0.001), whereas the carbonyl reduction of menadione (a cytosolic carbonyl reductase-dependent activity) was higher (P&lt; 0.05). Exposure to the herbicide had no effects on enzymatic activities dependent on carboxylesterases, glutathionetransferases, and uridinediphosphoglucuronosyltransferases. This research demonstrated certain biochemical modifications after exposure to a GLP-based herbicide. Such modifications may affect the metabolic fate ofdifferent endobiotic and xenobiotic substances. The pharmacotoxicological significance of these findings remains to be clarified.","palabras_clave":"GLYPHOSATE|XENOBIOTIC-METABOLIZING ENZYMES|NON-TARGET SPECIES|RATS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39751,"idioma_id":4,"titulo":"Energy Conservation and Solar Energy Use for Cooking Impact of Its Massive Adoption in the Arid Zone of Argentina","resumen":"The use of solar energy, together with energy conservation, is an essential task to transform human habitat into sustainable places. This paper presents the positive impact produced by the adoption of energy-efficient equipment for cooking, both, by the use of the heat retention box cooker and the solar drum oven in the arid zone of Argentina. These can improve the quality of life of populations and, at the same time, save energy, time and effort in trying to obtain firewood, with less serious health problems associated and GHG emissions control. It is demonstrated that savings of 65.7% of Liquefied Petroleum Gas and 63.8 % of Firewood utilized in rural and arid zone. From this manner, a reduction of 3.09 kgCO2e per cápita from 2015-2050 of greenhouse gases emitted to the environment are possible when 50% of arid zone population have adopted the technology.","palabras_clave":"energetic- efficient cooking|solar cooking|arid zones"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39752,"idioma_id":4,"titulo":"Comparison of Human T cell Leukemia Virus-1\/2 (HTLV-1\/2) screening assays in South America: Implications in the loss of blood units","resumen":"Although the detection of HTLV antibodies became mandatory in Argentinean blood banks since 2005, there is no recommendation on how to perform the screening. As a consequence, there is a variable number of HTLV false positives depending on the kit used. The aim of the present study was to evaluate the performance of six commercial screening tests available currently for the initial diagnosis of HTLV-1\/2 infection in South America. The positive panel included 14 HTLV-1 and 13 HTLV-2 samples confirmed by WB (HTLV-1\/2 MP Diagnostics). The negative panel included 233 samples analysed with Architect (n=47), Diapro (n=46), MP (n=45), Murex (n=47) and Serodia (n=48), collected in 5 different institutions in a period of one up to 10 consecutive days. All of them were confirmed by n-PCR. The sensitivity for all HTLV diagnostic kits was 100.0%. The most specific test was Serodia (PA) (99,1%; 2\/233), followed by the ELISAs: Celquest (98.3%, 4\/233), Murex (97.8%; 5\/233), MP and Architect (97.4%; 6\/233), and Diapro (93,1%; 16\/233). According to this data, 2 to 16 blood units out of 233 should have been discarded due to false positive results in a period of 10 days. This data must be considered when choosing the assays, not only to obtain an optimal efficiency on HTLV-1\/2 diagnosis, to increase the number of potential blood units and to decrease the circulation of anxious individuals without a final result, but also to lower the overall cost-benefits of the diagnosis in the health care system.","palabras_clave":"HTLV-1\/2|SCREENING|SOUTH AMERICA|BLOOD UNITS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39753,"idioma_id":4,"titulo":"Zeolite, study of aptitude as a natural pozzolan applied to structural concrete","resumen":"Nowadays concrete is, among construction materials, one of the most widely used due to its low price, appropriate mechanic characteristics and durability. Also, due to its ease to adopt diverse forms y sizes (Najimi, Sobhani, Ahmadi &amp; Shekarchi, 2012). Owing to the importance in the use of concrete as a structural material and to its impact in the environment as a consumer of great quantities of natural resources and emitter of CO2 in the concrete industry, it is necessary to develop from the science of materials, mixtures that support the growth of the construction industry and that consider the environment. Therefore, it becomes necessary to develop energetically efficient materials.A natural zeolite is studied as a material with potential pozzolanic activity and as a possible partial replacement in different percentages of Portland cement in structural concrete. The results of the mechanic trials in concrete samples prove the feasibility of using this element as pozzolanic material. Key words: zeolite, concrete, pozzolan, active additive, replacement.","palabras_clave":"ZEOLITE|CONCRETE|POZZOLAN|REPLACEMENT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39754,"idioma_id":4,"titulo":"Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta","resumen":"Breast cancer is the most common malignancy in women and the appearance of distant metastases produces the death in 98% of cases. The  retinoic acid receptor b (RARb) is not expressed in 50% of invasive breast carcinoma compared with normal tissue and it has been associated  with lymph node metastasis. Our hypothesis is that RARb protein participates in the metastatic process. T47D and MCF7 breast cancer cell lines  were used to perform viability assay, immunobloting, migration assays, RNA interference and immunofluorescence. Administration of retinoic  acid (RA) in breast cancer cells induced RARb gene expression that was greatest after 72 hrs with a concentration 1 lM. High concentrations  of RA increased the expression of RARb causing an inhibition of the 60% in cell migration and significantly decreased the expression of migration-  related proteins [moesin, c-Src and focal adhesion kinase (FAK)]. The treatment with RARa and RARc agonists did not affect the cell  migration. On the contrary, the addition of the selective retinoid RARb-agonist (BMS453) significantly reduced cell migration comparable to RA  inhibition. When RARb gene silencing was performed, the RA failed to significantly inhibit migration and resulted ineffective to reduce moesin,  c-Src and FAK expressions. RARb is necessary to inhibit migration induced by RA in breast cancer cells modulating the expression of proteins  involved in cell migration.","palabras_clave":"RETINOIC ACID|RAR BETA|FAK|MOESIN|CELL MIGRATION|BREAST CANCER CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39755,"idioma_id":4,"titulo":"Health insurance status and outcomes of critically ill obstetric patients: a prospective cohort study in Argentina","resumen":"PURPOSE:   In Argentina, uninsured patients receive public   health care, and the insured receive private health care. Our aim was to   compare different outcomes between critically ill obstetric patients   from both sectors.  METHODS:   This is a prospective cohort,   including pregnant\/postpartum patients requiring admission to 1   intensive care unit in the public sector (uninsured) and 1 in the   private (insured) from January 1, 2008, to September 30, 2011.  RESULTS:   A   total of 151 patients were included in the study. In uninsured (n = 63)   vs insured (n = 88) patients, Acute Physiology and Chronic Evaluation   II (APACHE II) and Sequential Organ Failure Assessment scores were 11 ±   6.5 vs 8 ± 4 and 3 (2-7) vs 1 (0-2), respectively, and 84% vs 100%   received prenatal care (P = .001 for all). Multiple organ dysfunction   syndrome (MODS) was present in 32 (54%) uninsured vs 9 (10%) insured   patients (P = .001), and acute respiratory distress syndrome developed   in 18 (30.5%) of 59 vs 2(2%) of 88 (P = .001). Neonatal survival was 80%   vs 96% (P = .003). Variables independently associated with the   development of MODS were APACHE II (odds ratio, 1.30 [1.13-1.49]),   referral from another hospital (odds ratio, 11.43 [1.86-70.20]), lack of   health insurance (odds ratio 6.75 [2.17-20.09]), and shock (odds ratio   4.82 [1.54-15.06]). Three patients died, all uninsured.  CONCLUSIONS:   Uninsured   critically ill obstetric patients (public sector) were more severely   ill on admission and experienced worse outcomes than insured patients   (private sector). Variables independently associated with MODS were   APACHE II, shock, referral from another hospital, and lack of insurance.","palabras_clave":"Critical care|Insurance|Pregnancy|Pregnancy outcome"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39756,"idioma_id":5,"titulo":"Valoración nutricional de escolares de tres países iberoamericanos: Análisis comparativo de las referencias propuestas por el International Obesity Task Force (IOTF)  y la Organización Mundial de la Salud","resumen":"El índice de masa corporal (IMC) resulta un indicador útil para valorar la condición nutricional en la infancia y adolescencia. Si bien no existe consenso respecto a los valores o puntos de corte de IMC que deben utilizarse para la diagnosis del sobrepeso, la obesidad o la insuficiencia ponderal, las referencias propuestas por la Organización Mundial de la Salud (OMS) y la International Obesity Task Force (IOTF) son las más aceptadas. No obstante, existen discrepancias importantes en los resultados obtenidos en función de una u otra referencia. Objetivo: Analizar y  comparar la condición nutricional de una muestra internacional a partir del IMC, mediante la aplicación simultánea de las referencias recomendadas por la IOTF y la OMS. Métodos: Se calculó el IMC de 1289 escolares de 10 a 13 años de México, Venezuela y España. A cada niño le fue atribuida una categoría nutricional (bajo  peso, normopeso, sobrepeso y obesidad) utilizando el criterio de la IOTF (puntos de corte equivalentes a 18,5; 25 y 30 en adultos) y OMS (-1 DE: bajo peso +1DE: sobrepeso y +2 DE: obesidad). Las prevalencias de estado nutricional obtenidas por cada criterio fueron comparadas mediante la prueba de Chi-Cuadrado. Resultados: El porcentaje de escolares en cada una de las categorías nutricionales varió  significativamente en función de la referencia empleada. La prevalencia de malnutrición por exceso o por defecto fue, en ambos sexos y en los tres países, superior al emplear los parámetros OMS. La referencia OMS evidenció un 10,9% menos de niños normonutridos y un 13,1% más de malnutridos que la IOTF. Discusión: Los resultados de esta investigación permiten inferir que la referencia propuesta por la OMS resulta ser más ?preventiva? al momento de identificar individuos malnutridos. Se subraya la importancia de especificar los criterios empleados para la determinación del estado nutricional en los estudios de carácter epidemiológico, así como de contrastar las referencias empleadas para el diagnóstico. Conclusiones: Las referencias OMS para IMC sobrestiman la prevalencia de bajo peso, sobrepeso y obesidad en relación a los puntos de corte propuestos por el IOTF para el diagnóstico de la malnutrición.","palabras_clave":"ESTADO NUTRICIONAL|OMS|IOTF|NIÑOS Y ADOLESCENTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39757,"idioma_id":4,"titulo":"Derivative expansion approach to the interaction between close surfaces","resumen":"The derivative-expansion approach to the calculation of the interaction   between two surfaces is a generalization of the proximity force   approximation, a technique in widespread use in different areas of   physics. The derivative expansion has so far been applied to seemingly   unrelated problems in different areas; it is our principal aim here to   present the approach in its full generality. To that end, we introduce a   unified setting, which is independent of any particular application,   provide a formal derivation of the derivative expansion in that general   setting, and study some of its properties. With a view toward the   possible application of the derivative expansion to other areas, like   nuclear and colloidal physics, we also discuss the relation between the   derivative expansion and some time-honored uncontrolled approximations   used in these contexts. By putting them under similar terms as in the   derivative expansion, we believe that the path is open to the   calculation of next-to-leading-order corrections also for these   contexts. We also review some results obtained within the derivative   expansion, by applying it to different concrete examples and   highlighting some important points.","palabras_clave":"Casimir effect|Derivative expansion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39758,"idioma_id":4,"titulo":"Abstract- APOPTOSIS IN Leptodactylus chaquensis TESTIS DURING THE REPRODUCTIVE CYCLE","resumen":"There are limited data on apoptosis in amphibian?s testis but nothing is known in Leptodactylus chaquensis. The aim of this paper is to analyze the frequency of this process in adult male animals collected during the reproductive and postreproductive periods. Testis was processed for identification of apoptotic cells using the TUNEL technique and for transmission electron microscopy (TEM). Apoptosis percentage was determined in both periods counting the number (n°) of cysts with TUNEL positive cells \/n° total cysts of each stage of maturation. Seminiferous tubules of the reproductive period showed a greater number of cysts, with a significant predominance of primary spermatogonia (G1), secondary (G2) and primary spermatocytes (C1), than of the postreproductive ones. Apoptosis was evident at all stages of maturation and in both periods of the cycle. However, in the reproductive period, a significant increase in the percentage of TUNEL positive cysts, mainly at G2 and C1 stages, it was observed. TEM observations confirmed these results. Apoptotic cells show spherical morphology surrounded by clear halo, with cytoplasmic disorganization, fragmented nucleus with condensed chromatin. Apoptotic bodies were observed.  The highest percentage of apoptosis during the reproductive period may play a role in controlling the spermatogenesis process ensuring adequate spermatozoa production.","palabras_clave":"APOPTOSIS|TESTIS|AMPHIBIAN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39759,"idioma_id":5,"titulo":"Dispositivos de cuidado y medidas de seguridad curativas: estrategias para el abordaje terapéutico-penitenciario del peligroso en el contexto jurídico-penal argentino","resumen":"El artículo se propone reconstruir, desde una perspectiva antropológica, los modos concretos que adquiere la ejecución de medidas de seguridad curativas en términos de dispositivos de cuidado en el marco de instituciones penitenciarias. Las reflexiones aquí vertidas son producto del trabajo de campo (2010-2012) en el Servicio Psiquiátrico para varones del Servicio Penitenciario Federal argentino; y se encuentran fundamentadas en el relevamiento y análisis de los Legajos Personales Únicos de los allí alojados (donde son archivados, entre otros documentos, todos los informes producidos por los equipos tratantes sobre cada uno de ellos y diversos pasajes de los expedientes judiciales de cada caso), tanto como en algunas entrevistas realizadas a profesionales que desarrollan o han desarrollado funciones en estos servicios.","palabras_clave":"DERECHO PENAL|MEDIDAS DE SEGURIDAD|PELIGROSIDAD|INSTITUCIONES UNIVERSITARIAS|DISPOSITIVOS DE CUIDADO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39760,"idioma_id":4,"titulo":"Abstract-- Ultraestructure of ganglia involved in the innervation of reproductive system of the amphibian female","resumen":"It is known that the vertebrates reproductive function is also under a direct neural control. The aim of this work is to study the ultrastructure of ganglia origin of the nerves that innervate Rhinella arenarum ovary and oviduct.   Ganglion samples taken from the coelomic cavity, below the common intestinal artery, were fixed and processed following routine techniques for transmission electron microscopy.  The observations show:   a- neurons characterized by their large size, with nucleus showing a single prominent nucleoli and with chromatin condenses near the nuclear envelope. The cytoplasm shows the presence of: rough endoplasmic reticulum that is formed into clusters that correspond to the so-called Nissl corpuscles; Golgi apparatus surrounded by numerous vesicles; mitochondria and neurofilaments.   b- nerve fibers in which it could be observed neurofilaments, mitochondria and numerous vesicles. Two types of fibers can be identified unmyelinated and myelinated ones.         c- axon terminals some of which show multiple small electronlucid vesicles (probably containing acetylcholine) while in others coexist transparent small vesicles with larger vesicles presenting an electrondense core (containing high molecular weigh neurotransmitters).         Ultrastructural analyses allow us to suggest that ganglia would be autonomic prevertebral ones.","palabras_clave":"AMPHIBIAN|REPRODUCTIVE SYSTEM|INNERVATION|GANGLION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39761,"idioma_id":4,"titulo":"Abstract-- Biological role of a oviductal glycoprotein of 74 KDa (gp74) in amphibian fertilization.","resumen":"BIOLOGICAL ROLE OF A OVIDUCTAL GLYCOPROTEIN OF 74 KDA (GP74) INAMPHIBIAN FERTILIZATION Crespo CA, Medina MF, Ramos I y Fernández SNInstituto Superior de Investigaciones Biológicas INSIBIO (CONICET-UNT). Chacabuco 461. 4000. Tucumán.  At present is not known the role of an oviductal acidic protein of 74KDa (gp74), obtained from the jelly diffusible components, in amphibian fertilization. The aim of this work is to study the biological activity of gp74 and determined its participation together with Ca2+ in gameteinteractions.The oocytes fecundity progressively decreases as a function of time extraction of the diffusible components and the washing medium of the jelly coats. The addition of diffusible proteins, previouslypurified, partially restitute the fecundation rates which significantly increased by the addition of Ca2+ 4 mM. It was demonstrated that gp74 produce changes in the oocytes surface similar to those induced by acrosomallysines that arephysiologically released during the acrosomal reaction, being this effect enhances by Ca2+addition. The lytic effect is not observed on the oocyte in the absence of sperm. The same effect was obtained when sperm were previously treated with gp74 in the presence or absence of Ca2+. The results demonstrate for the first time in anuran amphibian that a specific glycoproteinacts on the sperm promoting the acrosomic content release. This effect is enhanced by the presence of the cation in the medium, suggesting that both participate as factor-cofactor for the acrosomic reaction induction.","palabras_clave":"CALCIUM|GLICOPROTEIN|FECUNDATION|AMPHIBIAN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39762,"idioma_id":4,"titulo":"Numerical Treatment of Interfaces for Second-Order Wave Equations","resumen":"Abstract  In this article we develop a numerical scheme to deal with interfaces between touching numerical grids when solving the second-order wave equation. We show that it is possible to implement an interface scheme of penalty type for the second-order wave equation, similar to the ones used for first-order hyperbolic and parabolic equations, and the second-order scheme used by Mattsson et al. 2008. These schemes, known as SAT schemes for finite difference approximations and penalties for spectral ones, and ours share similar properties but in our case one needs to pass at the interface a smaller amount of data than previously known schemes. This is important for multi-block parallelizations in several dimensions, for it implies that one obtains the same solution quality while sharing among different computational grids only a fraction of the data one would need for a comparable (in accuracy) SAT or Mattsson et al.?s scheme. The semi-discrete approximation used here preserves the norm and uses standard finite-difference operators satisfying summation by parts. For the time integrator we use a semi-implicit IMEX Runge Kutta method. This is crucial, since the explicit Runge?Kutta method would be impractical given the severe restrictions that arise from the stiff parts of the equations.","palabras_clave":"wave|equation|interfaces|penalties"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39763,"idioma_id":4,"titulo":"Abstract-- Subcellular study of rat liver treated with cadmium at low-dose","resumen":"The aim of this study is to evaluate the ultrastructural alterations in the liver parenchyma of rats treated with low doses of Cd2+. Wistarmale rats were intoxicated with 10 mg CdCl2\/kg orally administered for 12 weeks. Controls were treated with distilled water. The ratswere sacrificed on the 4th, 8th and 12th week and the liver was dissected and analyzed by routine techniques for transmission electronmicroscopy. The results showed that in controls animals, at all times analyzed, the subcellular structures of the liver parenchyma werepreserved. In contrast, Cd2+ treatment produced morphological alterations dependent on the treatment period. Ultrastructural changesin hepatocytes were observed after the 4th week, showing an increase in the number of lipid droplets, a decrease in glycogen granulesand dilated rough endoplasmic reticulum associated with swollen mitochondria with loss of crests. Sinusoidal congestion was alsoobserved with mild hypertrophy of Kupffer cells and formation of collagen fibers. On the 8th and 12th week of treatment most of thehepatocytes exhibited cytoplasmic vacuolization. In conclusion, these results demonstrate that since the 4th week of treatment with 10mg\/kg of Cd2+ the liver shows the first signs of toxicity and a progressive deterioration in its morphology, affecting its normalfunction.","palabras_clave":"CADMIO|LIVER|SUBCELLULAR|RATA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39764,"idioma_id":5,"titulo":"Revisando la psicologización de la religiosidad","resumen":"Este trabajo analiza los procesos de psicologización de la religiosidad en un ámbito identificado con las clases medias de Buenos Aires.  Con foco en versiones reavivadas del catolicismo y en experiencias vinculadas con la llamada Nueva Era, analiza comparativamente la especificidad de categorías y prácticas psi en esos ámbitos. Dando prioridad a la cultura letrada urbana por sobre la denominaciones religiosas, propone un análisis contrastivo con los modos diferenciales de construcción de la persona psicológica en espacios seculares de la cultura letrada e, incluso, en la religiosidad de los sectores populares.","palabras_clave":"PSICOLOGIZACION|CULTURA LETRADA|CATOLICISMO|NUEVA ERA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39765,"idioma_id":4,"titulo":"ZrO2 -modified Al2O3 -supported PdCu catalysts for the water denitrification reaction","resumen":"Monometallic Pd and bimetallic Pd?Cu catalysts supported on alumina, zirconia and ZrO2?Al2O3mixedoxides of different composition were prepared and evaluated in the catalytic denitrification of water.The supports were characterized by X-ray diffraction (XRD), scanning electron microscopy with energydispersive X-ray (SEM\/EDX), NH3-adsorption thermogravimetry and specific surface areas measured bythe BET method. XRD studies showed that the predominant phase in the ZrO2-modified Al2O3supportsis the metastable tetragonal phase (57%) of zirconia. SEM\/EDX results indicated that ZrO2crystals aredistributed homogeneously on the supports. Temperature-programmed reduction (TPR) experimentscarried out on bimetallic PdCu catalysts showed that Pd is well dispersed on the modified supports andthat there is a strong interaction between both metals. The modification of Al2O3by the addition of ZrO2not only improved the activity but also the selectivity to N2of the PdCu catalysts.","palabras_clave":"nitrate|nitrite|water denitrification|catalysts"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39766,"idioma_id":4,"titulo":"Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia blainvillei, from Argentina","resumen":"Metallothioneins are signals of metal exposure and widely used in biomonitoring. Franciscana dolphin is an endemic cetacean from the Southwestern Atlantic Ocean, classified as Vulnerable A3d by the IUCN. Metallothionein, copper and zinc in Franciscana were assessed in two geographic groups; one inhabits La Plata River estuary, anthropogenically impacted, and the other inhabits marine coastal ecosystems, with negligible pollution. Despite the environment, hepatic and renal MT concentrations were similar, but there was a declining trend from early to later developmental stages. Metallothionein K\/L, Cu and Zn levels corresponded to normal reported ranges. MT was not related with Cd. Fetal concentrations were higher than its mother. These results and the health status of dolphins are suggesting that MT correspond to physiological ranges for the species, and they are closely to homeostasis of Zn and Cu, according to its ontogenetic changes. The information constitutes the first MT information on Franciscana dolphin and can be considered as baseline for the species conservation.","palabras_clave":"Metallothioneins|Biomarker|Ontogeny|Trace elements"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39767,"idioma_id":5,"titulo":"La violencia invisible. Hechicería, agresión y persona en los Andes","resumen":"la hechicería constituye un elemento central en la socialidad de las poblaciones rurales y urbanas del noroeste de Argentina. Este trabajo pretende poner en relación las prácticas de hechicería (o daño) en el horizonte más amplio de un orden socio-cosmológico, que en términos contrastivos, es propio del mundo andino. Para ello recurre a la noción de persona como una llave interpretativa situada y comparada para entender el lugar singular de la práctica de la hechicería y la contra-hechicería como modos de producir aflicción o bienestar. Insiste también en la agresión como parte de una trama relacional más amplia, usualmente entendida únicamente a la luz de la solidaridad y la ayuda mutua.","palabras_clave":"HECHICERIA|SOCIALIDAD|PERSONA|ANDES ARGENTINOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39769,"idioma_id":4,"titulo":"The morphology and relationships of the walking mud spiders of the genus Cryptothele (Araneae: Zodariidae)","resumen":"A b s t r a c tWe revise the relationships of the spider genus Cryptothele after reexamination of the morphology of the spinnerets, leg tarsal claws and maxillae with scanning electron microscopy. Cryptothele species have a particular conformation of the spinning field of the anterior lateral spigots that is typical of zodariids and close relatives: the field of major ampullate gland spigots, together with their strain sensilla, are invaginated within the field of piriform gland spigots. The implantation of the teeth on the inner side of the leg tarsal claws is also consistent with its placement among zodariids. We added Cryptothele to a morphological dataset of zodariid genera, together with the outgroups Homalonychus (Homalonychidae) and Penestomus (Penestomidae). The phylogenetic analysis concludes that the genus Cryptothele is a member of the subfamily Cydrelinae, which by priority is here considered a junior synonym of Cryptothelinae. Cryptothele specimens cover most of their body with soil particles which become consolidated as mud, and the debris is probably held in place by curved setae covered by long barbs. The spinnerets, which can be retracted and hidden, as well as the booklungs, are surrounded by a crown of thick setae that are densely covered by short barbs, protecting those areas against soil particles. Cryptothele are probably specialized to prey on termites, and their phylogenetic placement indicates that this diet specificity evolved two times independently in zodariids.","palabras_clave":"PHYLOGENY|ZODARIIDAE|TROPICAL|CRYPTIC|DIRT ADHESION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39770,"idioma_id":4,"titulo":"Egg yolk antibodies (IgY) against Bovine Leukemia Virus","resumen":"Bovine Leukemia Virus (BLV) is distributed worldwide and causes important economic losses on dairy farms. Currently, there are no effective vaccines or antivirals against BLV. Egg yolk antibodies (IgY) has many advantages over mammalian IgG. Despite the higher yields, they are non-invasively extracted from egg yolk, do not cross react against mammalian antigens or activate the mammalian complement system. In this work we evaluate the reactivity of Igy antibodies against Bovine Leukemia Virus p24 core protein and against the whole virus particle. Hens were immunized by intramuscular inoculation with purified p24 or the virus particle until the development of high antibody-titers. Total IgY was purified from egg yolks by ammonium sulfate precipitation. The purified egg yolk antibodies strongly reacted with BLV particles from a persistently infected cell line, with supernatants from ex vivo cultures of PBMCs from natural infected animals and also with purified p24 by both ELISA and Western blot. These data suggest that chicken IgY may be a suitable platform to produce large amounts of anti-BLV antibodies for diagnostic systems. Furthermore, the use of IgY for passive immunization against BLV infection should also be explored in order to develop new strategies to control the disease in cattle.","palabras_clave":"antibodies egg yolk|blv|protection"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39771,"idioma_id":4,"titulo":"Epidemiological features of BLV natural infection","resumen":"Dairy farms are heavily infected with Bovine Leukemia Virus (BLV) in Argentina and many other countries, where a control strategy should be design based on the behavior of natural. We conducted a series of studies with the aim to better understand the epidemiology of BLV. Infected new born calves were present in 3 studied farms (8.3%-11%). Proviral load (PVL) was very low in 9\/10 new born analyzed calves but rapidly augmented during the first months of age. Cross-sectional studies showed that the rate of high PVL between seroreactors raised together with the prevalence, from 20.2% at 8 months of age to 44.4% in 26 months heifers, with similar levels to adult lactating cows of the same farm. Low fluctuation of blood PVL was observed on animals with naturally-acquired infections. We also observed 10 seroconversions between young heifers with an initial elevation of PVl. The presence of provirus in colostrum was significantly correlated with blood PVL (p&#8804;0.0001). Provirus in milk was detectable in bulk tank (17.2%) and individual samples (40.4%). Colostrum of individual cows showed different provirus\/antibodies dual profiles that permit to speculate about different infective\/protective potential among infected animals. These findings suggest animals would be exposed to the infective challenge since a very young age. Consequently, it must be control as soon as possible after birth. The main focus should be put on the new-born infected calves that could play the role of main propagators together with the putative oral exposition through colostrum and milk.","palabras_clave":"BLV epidemiology|proviral load|antibodies|incidence"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39772,"idioma_id":4,"titulo":"Incorporation of inorganic mercury (Hg2+) in pelagic food webs of ultraoligotrophic and oligotrophic lakes: the role of different plankton size fractions and species assemblages","resumen":"In lake food webs, pelagic basal organisms such as bacteria and phytoplankton incorporate mercury (Hg2+) from the dissolved phase and pass the adsorbed and internalized Hg to higher trophic levels. This experimental investigation addresses the incorporation of dissolved Hg2+ by four plankton fractions (picoplancton: 0.2?2.7 µm; pico+nanoplankton: 0.2-20 µm; microplankton: 20-50 µm; and mesoplankton: 50-200 µm) obtained from four Andean Patagonian lakes, using the radioisotope 197Hg2+. Species composition and abundance were determined in each plankton fraction. In addition, morphometric parameters such as surface and biovolume were calculated using standard geometric models. The incorporation of Hg2+ in each plankton fraction was analyzed through three concentration factors: BCF (Bioconcentration factor) as a function of cell or individual abundance, SCF (Surface concentration factor) and VCF (Volume concentration factor) as functions of individual exposed surface and biovolume, respectively. Overall, this investigation showed that through adsorption and internalization, pico+nanoplankton play a central role leading the incorporation of Hg2+ in pelagic food webs of Andean lakes. Larger planktonic organisms included in the micro- and mesoplankton fractions incorporate Hg2+ by surface adsorption, although at a lesser extent. Mixotrophic bacterivorous organisms dominate the different plankton fractions of the lakes connecting trophic levels through microbial loops (e.g., bacteria-nanoflagellates-crustaceans; bacteria-ciliates-crustaceans; endosymbiotic algae-ciliates). These bacterivorous organisms, which incorporate Hg from the dissolved phase and through their prey, appear to explain the high incorporation of Hg2+ observed in all the plankton fractions.","palabras_clave":"PLANKTON|SIZE FRACTIONS|MERCURY ADSORPTION AND INTERNALIZATION|DEEP AND SHALLOW NORTH PATAGONIAN LAKES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39773,"idioma_id":4,"titulo":"Differences in diet composition and foraging patterns between sexes of the Magellanic penguin (Spheniscus magellanicus) during the non-breeding period as revealed by &#948;13C and &#948;15N values in feathers and bone","resumen":"In diving seabirds, sexual dimorphism in size often results in sex-related differences of foraging patterns. Previous research on Magellanic penguins, conducted during the breeding season, failed to reveal consistent differences between the sexes on foraging behavior, despite sexual dimorphism. In this paper, we tested the hypothesis that male and female Magellanic penguins differ in diet and foraging patterns during the non-breeding period when the constraints imposed by chick rearing activities vanish. We used stable isotope ratios of carbon and nitrogen in feather and bone to characterize the diet and foraging patterns of male and female penguins in the South Atlantic at the beginning of the 2009-2010 and 2010-2011 post-breeding seasons (feathers) and over several consecutive breeding and migratory seasons (bone). The mean &#948;13C and &#948;15N values of feathers showed no differences between the sexes in any of the three regions considered or in the diet composition between the sexes from identical breeding regions; however, Bayesian ellipses showed a higher isotopic niche width in males at the beginning of the post-breeding season. Stable isotope ratios in bone revealed the enrichment of males with &#948;13C compared with females across the three regions considered. Furthermore, the Bayesian ellipses were larger for males and encompassed those of females in two of the three regions analyzed. These results suggest a differential use of winter resources between the sexes, with males typically showing a larger diversity of foraging\/migratory strategies. The results also show that dietary differences between male and female Magellanic penguins may occur once the constraints imposed by chick rearing activities cease at the beginning of the post-breeding season.&nbsp;","palabras_clave":"Magellanic penguin|Spheniscus magellanicus|diet composition|ä13C & ä15N"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39774,"idioma_id":4,"titulo":"An improved trajectory-based hybrid metaheuristic applied to the noisy DNA Fragment Assembly Problem","resumen":"The DNA Fragment Assembly Problem (FAP) is an NP-complete that consists in reconstructing a DNA sequence from a set of fragments taken at random. The FAP has been successfully and efficiently solved through metaheuristics. But these methods usually face difficulties to succeed when noise appears in the input data or during the search, specially in large instances. In this regard, the design of more efficient techniques are indeed necessary. One example of these techniques found in literature is the Problem Aware Local Search (PALS) which represents a state-of-the-art and robust assembler to solve noisy instances. Although PALS performs better than other metaheuristics, the quality of the achieved solutions by this method can still be improved. Towards this aim, this work proposes a new hybrid and effective method that combines a local search technique specially designed for this problem (PALS) with Simulated Annealing (SA), which is further distributed following an island model. Our proposed hybrid approach showed an improved performance on the largest non-noisy and noisy instances when compared separately with Simulated Annealing and PALS.","palabras_clave":"DNA FRAGMENT ASSEMBLY PROBLEM|METAHEURISTIC|PARALLELISM|SIMULATED ANNEALING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39775,"idioma_id":4,"titulo":"Empirical evaluation of distributed differential evolution on standard benchmarks","resumen":"This paper presents a new distributed Differential Evolution (dDE) algorithm and provides an exhaustive evaluation of it by using two standard benchmarks. One of them was proposed in the special session of Real-Parameter Optimization of CEC'05, and the other was proposed in the special session of Large Scale Global Optimization of CEC'08. We statistically validate and compare our results versus all other techniques presented in these special sessions. This means that more than 25 problems, with different dimensions: 30, 50, 100, and 500 variables, are evaluated; and 15 algorithms are compared in the experiments. Our dDE is simple, accurate, and competitive when applied to a wide variety of problems, with scaling dimensions, and different function features: noisy, non-separable, multimodal, rotated, etc.","palabras_clave":"BENCHMARKING|DISTRIBUTED DIFFERENTIAL EVOLUTION|NON- PARAMETRIC TEST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39776,"idioma_id":4,"titulo":"Model Design for a Reduced Variant of a Trivium Type Stream  Cipher.","resumen":"The paper analyze the family of stream ciphers N-viums: Trívium and Bivium and its variants. In particular the NLFSRs used in these generations.","palabras_clave":"CRIPTOLOGY|ALGORITHM|TRIVIUM|STREAM CIPHER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39777,"idioma_id":4,"titulo":"A comparative analysis of prenatal care and fetal growth in eight South American countries","resumen":"There has been little work that comprehensively compared the   relationship between prenatal care and infant health across multiple   countries using similar data sources and analytical models. Such   comparative analyses are useful for understanding the background of   differences in infant health between populations. We evaluated the   association between prenatal care visits and fetal growth measured by   birth weight (BW) in grams or low birth weight (&lt;2500 grams; LBW)   adjusted for gestational age in eight South American countries using   similarly collected data across countries and the same analytical   models. OLS and logistic regressions were estimated adjusting for a   large set of relevant infant, maternal, and household characteristics   and birth year and hospital fixed effects. Birth data were acquired from   140 hospitals that are part of the Latin American Collaborative Study   of Congenital Malformations (ECLAMC) network. The analytical sample   included 56,014 live-born infants (&#8764;69% of total sample) with complete   data born without congenital anomalies in the years 1996-2011 in Brazil,   Argentina, Chile, Venezuela, Ecuador, Colombia, Bolivia, and Uruguay.   Prenatal care visits were significantly (at p&lt;.05) and positively   associated with BW and negatively associated with LBW for all countries.   The OLS coefficients ranged from 9 grams per visit in Bolivia to 36   grams in Uruguay. The association with LBW was strongest for Chile   (OR&#8202;=&#8202;0.87 per visit) and lowest for Argentina and Venezuela   (OR&#8202;=&#8202;0.95). The association decreased in the recent decade compared to   earlier years. Our findings suggest that estimates of association   between prenatal care and fetal growth are population-specific and may   not be generalizable to other populations. Furthermore, as one of the   indicators for a country´s healthcare system for maternal and child   health, prenatal care is a highly variable indicator between countries   in South America.","palabras_clave":"prenatal care|fetal growth|south american countries"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39778,"idioma_id":5,"titulo":"Estado nutricional y presión arterial en niños de la provincia del Chaco, Argentina","resumen":"La provincia del Chaco, Argentina, posee una población de 1.055.259 habitantes, siendo una de las que tiene mayor población pediátrica y aborigen del país.    El objetivo del presente estudio es conocer las cifras de presión arterial (PA) y estado nutricional (EN) en población pediátrica del Chaco y describir las diferencias encontradas entre la población caucásica (CP) y aborígenes de la etnia Toba (AT) en menores de 10 años.    Estudio con una muestra no aleatoria, de 678 niños de 1-17 años realizado en sus casas. Se utilizaron las tablas elaboradas por la OMS 2007 para determinar el EN. La PA se tomó adaptando la técnica descrita en el IV Reporte de PA en niños y adolescentes.    Según la edad y la etnia, los niños participantes se dividieron en 4 grupos: grupo I, 90 (13,3%) AT menores a 10 años; grupo II, 52 (7,7%) de CP del mismo rango de edad; grupo III, 190 (28%) CP de 11-13 años y grupo IV, 346 (51%) CP de 14-17 años. El riesgo de sobrepeso y el sobrepeso se encontraron entre el 24-46% de los niños. Presentaron bajo peso el 2,7% (IC 95% 1,6-4,2).    Se detectaron cifras tensionales mayores o iguales al percentil 95 en el 42% de los del grupo I, 30% del grupo II, 21% del grupo III, 16% del grupo IV (p < 0,05).    La frecuencia de sobrepeso hallada es superior a la de estudios realizados en Canadá y Buenos Aires y menor a la de Estados Unidos. Los AT presentaron mayor frecuencia de peso normal y menor estatura.","palabras_clave":"Obesidad|Hipertensión arterial|Etnia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39779,"idioma_id":4,"titulo":"Reactivity and Selectivity of Boron-substituted Alkenes in the Diels-Alder Reaction with Cyclopentadiene. A Study of the Electron Charge Density and Its Laplacian","resumen":"The effect of the nature of the boron moiety upon the reactivity and the selectivity of a variety of vinylboron dienophiles (1-12) in the Diels-Alder (DA) reaction was investigated using the density functional theory and the quantum theory of atoms in molecules. The calculated reactivity of the dienophiles decreases in the order: vinylborane (1) &gt; dihalovinylboranes (2-4) &gt; dialkylvinylboranes (5-7) ~ vinyl boronic acid (8) &gt; vinylboronates (9-10) &gt; vinyl MIDA boronate (11) ~ vinyltrifluoroborate (12). The DA reactions of 1-7 were slightly endo-selective due to the stronger C6-B secondary orbital interaction in the endo transition structures (TSs) evaluated by the C6|B delocalization index. In the TSs of 5 and 7 a combination of electronic and steric factors reduce the endo selectivity. The moderate exo-selectivity calculated for the DA reactions of boronates 8-11 was attributed mainly to the hydrogen bond between the oxygen atom of boronate moieties and one of the acidic hydrogen of the methylene of cyclopentadiene in the exo TSs, which also reduces the ability of the oxygen lone pairs to donate electron density into the vacant boron orbital. Interestingly, the cooperative effect between the two hydrogen bonds in the exo TS of the DA reaction of vinyltrifluoroborate (12) determines the almost exclusive exo selectivity predicted for this DA reaction. We propose that the relative reactivities of the dienophiles can be estimated by the charge density ( rr) and its Laplacian (Ñ2 rr) at the(3,+1) critical point in the topology of Ñ2 rr, evaluated at the reactant molecules in the ground state. The profiles of the several topological parameters along the reaction are affected by the nature of the substituents attached to the boron atom and by the mode of addition (endo and exo) in the DA reactions.","palabras_clave":"BORON-SUBSTITUTED DIENOPHILES|DFT|QTAIM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39780,"idioma_id":4,"titulo":"Do alien and native tree species from Central Argentina differ in their water transport strategy","resumen":"In this study we assessed the water transport strategies and the abundance of alien and native tree species at a regional scale in Córdoba Mountains, Central Argentina. The aims of this study were: 1) to analyze whether alien and native tree species show divergent water transport strategies; and 2) to explore whether species abundances of alien and natives are associated with specific trait attributes. Eight alien species and 12 native species were recorded in 50 complete vascular plant vegetation relevés. Water transport strategies were assessed through the following functional traits: minimum leaf water potential, potential water content of wood, effective leaf area, leaf area per sapwood area, and wood density. Also, resource use strategies were assessed throughout the measurement of specific leaf area. We found that alien species had a higher efficiency in water transport (i.e. higher minimum leaf water potential and lower wood density values) and faster resource acquisition and use (higher specific leaf area values) than native species. We did not find evidence suggesting that the relative abundance of species was associated to water transport strategies and faster resource acquisition and use. Alien species seem to differ from natives in specific functional attributes that are absent in the resident community and might allow aliens to use more resources and at a higher rate than native species. Finally, our results show the potential of a trait based predictive framework for alien species, and the possible effects on ecosystem functions.","palabras_clave":"biological invasions|functional ecology|leaf area per sapwood area|alien woody species"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39781,"idioma_id":4,"titulo":"c-Fos: An AP-1 transcription factor with an additional cytoplasmic, non-genomic lipid synthesis activation capacity","resumen":"The mechanisms that co-ordinately activate lipid synthesis when high rates of membrane biogenesis are needed to support cell growth are largely unknown. c-Fos, a well known AP-1 transcription factor, has emerged as a unique protein with the capacity to associate to specific enzymes of the pathway of synthesis of phospholipids at the endoplasmic reticulum and activate their synthesis to accompany genomic decisions of growth. Herein, we discuss this cytoplasmic, non-genomic effect of c-Fos in the context of other mechanisms that have been proposed to regulate lipid synthesis.","palabras_clave":"Membrane biogenesis regulation|PI4KII&#945;\/c-Fos association|Phospholipid synthesizing enzymes regulation|c-Fos\/CDS association"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39782,"idioma_id":4,"titulo":"c-Fos-activated Synthesis of Nuclear Phosphatidyl Inositol-4,5-bisphosphate [PtdIns(4,5)P2] Promotes Global Transcriptional Changes","resumen":"c-Fos is a well-recognized member of the AP-1 family of transcription factors. In addition to this canonical activity, we previously showed that cytoplasmic c-Fos activates phospholipid synthesis through a mechanism independent of its genomic AP-1 activity. c-Fos associates with particular enzymes of the pathway of synthesis of lipids at the endoplasmic reticulum and increases the Vmax of the reactions without modifying the Km values. This lipid synthesis activation is associated to events of differentiation and proliferation that require high rates of membrane biogenesis. Since lipid synthesis also occurs in the nucleus, and different phospholipids have been assigned transcription regulatory functions, herein we examine if c-Fos also acts as a regulator of phospholipid synthesis in the nucleus. Furthermore, we examine if c-Fos modulates transcription through its phospholipid synthesis activator capacity. We show that nuclear-localized c-Fos associates with and activates Phosphatidyl Inositol 4 monophosphate 5 Kinase [PI4P5K] but not with Type III Beta Phosphatidyl Inositol 4 Kinase [PI4KIII&#946;] thus promoting Phosphatidyl Inositol-4,5-bisphosphate [PtdIns(4,5)P2] formation which, in its turn, promotes transcriptional changes. We propose c-Fos as a key regulator of nuclear PtdIns(4,5)P2 synthesis in response to growth signals that results in c-Fos-dependent transcriptional changes promoted by the newly synthesized lipids.  Summary statement: c-Fos promotes transcriptional changes by activating Phosphatidyl Inositol-4,5-bisphosphate synthesis in the nucleus. Regulatory transcriptional functions of c-Fos can now be extended to its phospholipid synthesis activator capacity, which means that new mechanisms of transcriptional regulation can be envisaged","palabras_clave":"fos|Lipidos|Nucleo Celular|Sintesis Nuclear"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39783,"idioma_id":5,"titulo":"La Tragedia de calle Salta (Rosario- Argentina). Reflexionando las prácticas de intervención de Trabajo Social","resumen":"En el artículo se comparte la experiencia de trabajo llevada a cabo por integrantes de nuestro equipo de investigación, en una Jornada organizada por el Colegio de Trabajadores Sociales de Rosario, realizada 40 días después de la explosión del edificio sobre calle Salta, en la ciudad de Rosario, Santa Fe, Argentina, en el año 2014. Con trabajadoras sociales que intervinieron en esta situación de desastre.","palabras_clave":"TRAGEDIA|EMERGENCIA|AFECTACIÓN|SUBJETIVA|CRISIS|FORMACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39784,"idioma_id":4,"titulo":"Atomistic Simulation of Tantalum Nanoindentation: effects of indenter diameter, penetration velocity, and interatomic potentials on defect mechanisms and evolution","resumen":"Nanoindentation simulations are a helpful complement to experiments. There is a dearth of nanoindentation simulations for bcc metals, partly due to the lack of computationally efficient and reliable interatomic potentials at large strains. We carry out indentation simulations for bcc tantalum using three different interatomic potentials and present the defect mechanisms responsible for the creation and expansion of the plastic deformation zone: twins are initially formed, giving rise to shear loop expansion and the formation of sequential prismatic loops. The calculated elastic constants as function of pressure as well as stacking fault energy surfaces explain the significant differences found in the defect structures generated for the three potentials investigated in this study. The simulations enable the quantification of total dislocation length and twinning fraction. The indenter velocity is varied and, as expected, the penetration depth for the first pop-in (defect emission) event shows a strain rate sensitivity m in the range of 0.037-0.055. The effect of indenter diameter on the first pop-in is discussed. A new intrinsic&nbsp; length-scale model is presented based on the profile of the residual indentation and geometrically-necessary dislocation theory.","palabras_clave":"MD Simulation|Tantalum|Nanoindentation|Plasticity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39785,"idioma_id":4,"titulo":"Latitudinal variation in clutch size-lay date regressions in Tachycineta swallows: effects of food supply or demography?","resumen":"In a study of almost 16,000 nest records from seven swallow species across the entire Western Hemisphere, clutch sizes decline with relative laying date in each population, but the slope of this decline grows steeper with increasing distance from the equator. Late-laying birds at all latitudes lay clutches of similar sizes, suggesting that latitudinal differences may be driven primarily by earlier-laying birds. Focused comparisons of site-years in North America with qualitatively different food availability indicate that food supply significantly affects mean clutch size but not the clutch size-lay date regression. Other studies on the seasonality of swallow food also indicate that steeper clutch size-lay date declines in the North are not caused by steeper earlier food peaks there. The distribution of lay dates grows increasingly right-skewed with increasing latitude. This variation in lay-date distributions could be due the predominance of higher quality, early-laying (and large-clutched) individuals among populations at higher latitudes, resulting from latitudinal variation in mortality rates and the intensity of sexual selection. Our results underscore the importance of studying clutch size and lay date in tandem and suggest new research into the causes of their joint geographic variation.","palabras_clave":"lay date|life history traits|geographic variation|Swallows"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39786,"idioma_id":4,"titulo":"Experimental determination of Naproxen solubility in organic solvents and aqueous binary mixtures: interactions and thermodynamic parameters relating to the solvation process","resumen":"The experimental solubility of Nap in fifteen pure solvents and in eight aqueous-organic cosolvent mixtures was determined. The results obtained indicate that the &#61552; parameter which describes the polarity\/polarizability of the solvent, and the &#61552; Hildebrand´s solubility parameter, which accounts for the cohesive forces of the solvent, have a greater influence on the solubility of Nap. This drug has a lower solubility (T=300.0 ±0.3 K) in water (3.02 10-4 M) and a greater solubility in DMS (1.56 M) and DMF (1.48M). In all the cosolvent mixtures analyzed, the solute was preferentially solvated by the organic cosolvent. For the aqueous binary mixtures formed by ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropic and Gibbs free energy changes involved with the solvation process were determined. In the three systems analyzed, it can be seen that the process is always entropically favorable and endothermic or unfavorable, hence, solute-solute and\/or solvent-solvent interactions predominate. The solution process is driven by the enthalpy term. The contributions of enthalpy and therefore entropy do not change when modifying the composition of the mixture of cosolvents.","palabras_clave":"NAPROXEN|COSOLVENT|SOLUBILITY|THERMODYNAMIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39787,"idioma_id":4,"titulo":"Polymerase chain reaction-based assay for the detection and identification of sand fly  gregarines in Lutzomyia longipalpis, a vector of visceral leishmaniasis","resumen":"Gregarines that parasitise phlebotomine sand flies belong to the genus Psychodiella and, even though they are highly host-specific, only five species have been described to date. Their most outstanding features include the unique localisation of the oocysts in the accessory glands of the female host, which ensures contamination of the egg surface during oviposition, and the fact that they naturally parasitise the vectors of Leishmania, causal agent of leishmaniasis. The type species, Ps. chagasi, was first described in Lutzomyia longipalpis, vector of visceral leishmaniasis (VL), from Brazil. We recently reported Ps. chagasi sequences in Lu. longipalpis from Posadas (Misiones, Argentina), an endemic VL location where this gregarine had not been previously recorded. In order to analyse the incidence of Ps. chagasi infections in Lu. longipalpis from this location, the aim of this study was to develop a diagnostic assay for sand fly gregarine parasites in Lu. longipalpis. For this, we designed primers using the Ps. chagasi sequences we previously identified and performed an in vitro validation by PCR amplification of the original sand fly samples. Their specificity and sensitivity as diagnostic primers were subsequently confirmed by PCR reactions using total DNA extracted from naturally infected Lu. longipalpis from the same location (Posadas, Argentina).","palabras_clave":"SAND FLY GREGARINES|PSYCHODIELLA CHAGASI|DIAGNOSTIC PRIMERS|PCR-BASED ASSAY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39788,"idioma_id":4,"titulo":"A Catalase-Magnetic Switch for Cell Proliferation","resumen":"The advance of novel biotechnology requires the development of  versatile control systems for cell behavior. Towards the vision of cell growth  control, we report a magnetic switching in cell proliferation by a  catalase-nanomagnetite complex. The system synergically exploits both the  ability of catalase to scavenge cell-generated hydrogen peroxide, a messenger  involved in cell cycle regulation, and magnetite manipulation to modulate cell  proliferation between arrest and growth using magnetic fields. This ON\/OFF  switch methodology could constitute the basis of new classes of diagnostic and  therapeutic strategies as well as novel integrated responsive  biomaterials.","palabras_clave":"MAGNETIC NANOPARTICLES|CATALASE|PROLIFERATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39789,"idioma_id":5,"titulo":"Analisis de eficiencia comparativo entre dos diseños de surcadores de disco para siembra directa en un cultivo de trigo (Triticum aestivum L.)","resumen":"Ante las controversias generadas por la falta de información acerca del desempeño de los distintos órganos utilizados para la apertura del surco en siembra directa, en el Laboratorio de Terramecánica e Implantación de Cultivos del Instituto de Ingeniería Rural (INTA Castelar) se comenzaron a evaluar algunos de los principales implementos utilizados en los trenes de siembra en las áreas productivas más representativas de la Argentina.&nbsp;El objetivo de este trabajo fue realizar una evaluación comparativa de la eficiencia de implantación de dos surcadores de disco de gran adopción por los diseñadores de maquinaria agrícola. En cuanto a la profundidad de siembra elegida de 40 mm, los valores alcanzados fueron de 39,9 y 32,2 mm por el monodisco y el bidisco respectivamente. Se observó la influencia que genera la presencia de rastrojo sobre la eficiencia de implantación del cultivo de trigo y el desempeño de las cuchillas labrasurco.","palabras_clave":"SIEMBRA DIRECTA|EFICIENCIA DE IMPLANTACION|SEMBRADORAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39790,"idioma_id":4,"titulo":"Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis.","resumen":"AbstractOBJECTIVES: We used a screening strategy of global serum microRNA (miRNA) profiling, followed by a second stage of independent replication and exploration of liver expression of selected miRNAs to study: (1) the circulating miRNA signature associated with non-alcoholic fatty liver disease (NAFLD) progression and predictive power, (2) the role of miRNAs in disease biology and (3) the association between circulating miRNAs and features of the metabolic syndrome.METHODS: The study used a case-control design and included patients with NAFLD proven through biopsy and healthy controls.RESULTS: Among 84 circulating miRNAs analysed, miR-122, miR-192, miR-19a and miR-19b, miR-125b, and miR-375 were upregulated &gt;2-fold (p&lt;0.05) either in simple steatosis (SS) or non-alcoholic steatohepatitis (NASH). The most dramatic and significant fold changes were observed in the serum levels of miR-122 (7.2-fold change in NASH vs controls and 3.1-fold change in NASH vs SS) and miR-192 (4.4-fold change in NASH vs controls); these results were replicated in the validation set. The majority of serum miR-122 circulate in argonaute2-free forms. Circulating miR-19a\/b and miR-125b were correlated with biomarkers of atherosclerosis. Liver miR-122 expression was 10-fold (p&lt;0.03) downregulated in NASH compared with SS and was preferentially expressed at the edge of lipid-laden hepatocytes. In vitro exploration showed that overexpression of miR-122 enhances alanine aminotransferase activity.CONCLUSIONS: miR-122 plays a role of physiological significance in the biology of NAFLD; circulating miRNAs mirror the histological and molecular events occurring in the liver. NAFLD has a distinguishing circulating miRNA profile associated with a global dysmetabolic disease state and cardiovascular risk.","palabras_clave":"MICRORNA|NAFLD|NASH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39791,"idioma_id":4,"titulo":"'Electrical response of bivalent modifier cations into a Vanadium-Tellurite glassy matrix'","resumen":"In this work, we suggest an explanation of the electrical conductivity behavior of tellurite glassy systems  modified with barium when transition metal oxides (V2O5-MoO3) present in the glassy matrix are replaced  progressively by bariumoxide. These glasses of formula x BaO (1&#8722;x) (0.5V2O5 · 0.5MoO3) 2 TeO2 are obtained  by the standard quenching technique and analyzed by means of impedance spectroscopy. We also report some  structural results that explain the effect of the bivalent cation (Ba+2) on the electrical response in comparison  to the effect of univalent cations on this kind of glassy matrix. The results confirm the existence of a transition  from a typical hopping of small polarons response (when the content of BaO is low) to a weak ionic conductive  response (when more than 50% of the transition metal oxides content has been replaced by BaO). The independent  migration path is suggested by the observed electrical conductivity behavior. In this system, vanadiumgives  the active centers responsible for the polaron hopping mechanism while barium cations seem to be responsible  for the ionic transport regimen.","palabras_clave":"IONIC CONDUCTIVITY|OXIDE GLASSES|TELLURITE GLASSES|IMPEDANCE SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39792,"idioma_id":5,"titulo":"Análisis espacial del riesgo de establecimiento de Lymantria dispar en bosques nativos de Sudamérica","resumen":"Lymantria dispar es una plaga cuarentenaria ausente de Sudamérica, para la que se ha elaborado un plan de vigilancia fitosanitaria regional, debido su elevado riesgo de introducción involuntaria a través del comercio. El objetivo de este trabajo fue estimar la distribución geográfica potencial de L. dispar en una nueva área utilizando un enfoque deductivo, a fin de priorizar ambientes en riesgo para su monitoreo preventivo. En Sudamérica se evaluó la susceptibilidad de la cobertura boscosa ante diferentes escenarios climáticos. A escala local, en Argentina, se simuló la fenología potencial de la especie. A base de las condiciones climáticas históricas de Sudamérica, L. dispar podría establecerse en los bosques andinos desde el norte de Argentina, hasta Venezuela, la mata atlántica brasileña, áreas costeras litorales de Uruguay y Argentina y el área mediterránea del centro y sur de Chile. Los efectos del cambio climático estimados por el IPCC, provocarían una disminución de este área susceptible en las próximas décadas.  Aunque existieron diferencias significativas en la superficie clasificada como de mayor riesgo fitosanitario en las dos escalas de estudio (subcontinental vs. regional), se lograron identificar las principales áreas susceptibles para el monitoreo preventivo de L. dispar.","palabras_clave":"especie invasora|cambio climático|riesgo fitosanitario"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39793,"idioma_id":5,"titulo":"Relación con el saber. Un estudio con adultos que inician la escolaridad.","resumen":"Presentamos parte de un estudio dirigido a conocer la relación con el saber matemático y los conocimientos aritméticos de alumnos adultos que inician la escolaridad primaria.  Analizamos diferentes fuentes de movilización de los alumnos para ir a la escuela y aprender matemática, el rol de algunas figuras que han sido decisivas en sus relaciones con el saber y sus perspectivas sobre el origen de sus conocimientos matemáticos. Se explicitan aquellos conceptos sobre la relación con el saber que son usados como herramientas de relevamiento y análisis de los datos.  El estudio simultáneo de la relación con el saber y de los conocimientos matemáticos permitió enriquecer la mirada sobre las matemáticas de los sujetos entrevistados y reconocer cómo atribuyen significados personales a las porciones de sus matemáticas en interacción con sus historias de vida. Algunos resultados de esta investigación interpelan perspectivas didácticas vigentes en la enseñanza de la matemática a adultos.","palabras_clave":"Relacion con el saber|adultos|matemática|bajo nivel de escolarización"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39794,"idioma_id":4,"titulo":"Differential expression of immunogenic proteins on virulent Mycobacterium tuberculosis clinical isolates","resumen":"Molecular epidemiology has revealed that Mycobacterium tuberculosis (Mtb), formerly regarded as highly conserved specie, displays a considerable degree of genetic variability that can influence the outcome of the disease as well as the innate and adaptive immune response. Recent studies have demonstrated that Mtb families found  worldwide today differ in pathology, transmissibility, virulence and development of immune response. By proteomic approaches seven proteins that were differentially expressed between a local clinical isolate from Latin-American-Mediterranean (LAM)and from Haarlem (H) lineages were identified. In order to analyze the immunogenic ability, recombinant Rv2241, Rv0009, Rv0407 and Rv2624c proteins were produced for testing specific antibody responses. We found that these proteins induced humoral immune responses in patients with drug-sensitive and drug-resistant tuberculosis with substantial cross-reactivity among the four proteins. Moreover, such reactivity was also correlated with anti-Mtb-cell surface IgM, but not with anti-ManLAM, anti-PPD or anti-Mtb-surface IgG antibodies. Therefore, the present results describe new Mtb  antigens with potential application as biomarkers of TB.","palabras_clave":"TUBERCULOSIS|PROTEOMICS|SEROLOGY|IMMUNOINFORMATICS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39795,"idioma_id":4,"titulo":"Decay-accelerating factor 1 deficiency exacerbates leptospiral-induced murine chronic nephritis and renal fibrosis","resumen":"Leptospirosis is a global zoonosis caused by pathogenic Leptospira, which can colonize the proximal renal tubules and persist for long periods in the kidneys of infected hosts. Here, we characterized the infection of C57BL\/6J wild-type and Daf1-\/- mice, which have an enhanced host response, with a virulent Leptospira interrogans strain at 14 days post-infection, its persistence in the kidney, and its link to kidney fibrosis at 90 days post-infection. We found that Leptospira interrogans can induce acute moderate nephritis in wild-type mice and is able to persist in some animals, inducing fibrosis in the absence of mortality. In contrast, Daf1-\/- mice showed acute mortality, with a higher bacterial burden and renal inflammation. At the chronic stage, Daf1-\/- mice showed greater inflammation and fibrosis than at 14 days post-infection and higher levels at all times than the wild-type counterpart. Compared with uninfected mice, infected wild-type mice showed higher levels of IL-4, IL-10 and IL-13, with similar levels of &#945;-smooth muscle actin, galectin-3, TGF-&#946;1, IL-17, IFN-&#947;, and lower IL-12 levels at 90 days post-infection. In contrast, fibrosis in Daf1-\/- mice was accompanied by high expression of &#945;-smooth muscle actin, galectin-3, IL-10, IL-13, and IFN-&#947;, similar levels of TGF-&#946;1, IL-12, and IL-17 and lower IL-4 levels. This study demonstrates the link between Leptospira-induced murine chronic nephritis with renal fibrosis and shows a protective role of Daf1.","palabras_clave":"leptospirosis|Fibrosis|Daf1|Leptospira interrogans|Kidney"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39797,"idioma_id":4,"titulo":"Argument-based Mixed Recommenders and their Application to Movie Suggestion","resumen":"Recommender systems have become prevalent in recent years as they help users to access relevant items from the vast universe of possibilities available these days. Most existing research in this area is based purely on quantitative aspects such as indices of popularity or measures of similarity between items or users. This work introduces a novel perspective on movie recommendation that combines a basic quantitative method with a qualitative approach, resulting in a family of mixed character recommender systems. The proposed framework incorporates the use of arguments in favor or against recommendations to determine if a suggestion should be presented or not to a user. In order to accomplish this, Defeasible Logic Programming (DeLP) is adopted as the underlying formalism to model facts and rules about the recommendation domain and to compute the argumentation process. This approach has a number features that could be proven useful in recommendation settings. In particular, recommendations can account for several different aspects (e.g., the cast, the genre or the rating of a movie), considering them all together through a dialectical analysis. Moreover, the approach can stem for both content-based or collaborative filtering techniques, or mix them in any arbitrary way. Most importantly, explanations supporting each recommendation can be provided in a way that can be easily understood by the user, by means of the computed arguments. In this work the proposed approach is evaluated obtaining very positive results. This suggests a great opportunity to exploit the benefits of transparent explanations and justifications in recommendations, sometimes unrealized by quantitative methods.","palabras_clave":"Defeasible Argumentation|Recommender Systems|Qualitative vs Quantitative Recommendations"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39798,"idioma_id":5,"titulo":"Resultados tras la rehabilitaci&oacute;n vestibular y terapia Wii&reg; en pacientes con hipofunci&oacute;n vestibular unilateral cr&oacute;nica","resumen":"Introduction and objectives: Vestibular rehabilitation therapy is an exercise-based programme designed to promote central nervous system compensation for inner ear deficit. The objective of the present study was to analyse the differences in the perception of handicap, the risk of falls, and gaze stability in patients diagnosed with chronic unilateral vestibular hypofunction before and after vestibular rehabilitation treatment with complementary Wii® therapy.Materials and methods: A review was performed on the clinical histories of patients in the vestibular rehabilitation area of a university hospital between April 2009 and May 2011. The variables studied were the Dizziness Handicap Inventory, the Dynamic Gait Index and dynamic visual acuity. All subjects received complementary Wii® therapy.Results: There were 69 cases (41 woman and 28 men), with a median age of 64 years. The initial median Dizziness Handicap Inventory score was 40 points (range 0-84, percentile 25-75=20-59) and the final, 24 points (range 0-76, percentile 25-75=10.40), P<.0001. The initial median for the Dynamic Gait Index score was 21 points (range 8-24, percentile 25-75=17.5-2.3) and the final, 23 (range 12-24, percentile 25-75=21-23), P<.0001. The initial median for dynamicvisual acuity was 2 (range 0-6, percentile 25-75=1-4) and the final, 1 (range 0-3, percentile 25-75=0-2), P<.0001.Conclusion: A reduction was observed in the Dizziness Handicap Inventory Values. Values for the Dynamic Gait Index increased and dynamic visual acuity improved. All these variations were statistically significant.© 2013 Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial. All rights reserved.","palabras_clave":"ENFERMEDAD-VESTIBULAR|REHABILITACIÓN-VESTIBULAR|VIDEOJUEGOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39799,"idioma_id":4,"titulo":"Lacosamide Derivatives with Anticonvulsant Activity as Carbonic Anhydrase Inhibitors. Molecular Modeling, Docking and QSAR Analysis","resumen":"Lacosamide is an anticonvulsant drug which presents carbonic anhydrase inhibition. In this paper, we analyzed the apparent relationship between both activities performing a molecular modeling, docking and QSAR studies on 18 lacosamide derivatives with known anticonvulsant activity. Docking results suggested the zinc-binding site of carbonic anhydrase is a possible target of lacosamide and lacosamide derivatives making favorable Van der Waals interactions with Asn67, Gln92, Phe131 and Thr200. The mathematical models revealed a poor relationship between the anticonvulsant activity and molecular descriptors obtained from DFT and docking calculations. However, a QSAR model was developed using Dragon software descriptors. The statistic parameters of the model are: correlation coefficient, R=0.957 and standard deviation, S=0.162. Our results provide new valuable information regarding the relationship between both activities and contribute important insights into the essential molecular requirements for the anticonvulsant activity.","palabras_clave":"Lacosamide derivatives|Anticonvulsant activity|Carbonic Anhydrase|Molecular Docking|Dragon descriptors|QSAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39800,"idioma_id":5,"titulo":"Productividad de una plantación de espárrago (Asparagus officinalis var. altilis) verde iniciados por plantines a lo largo de cuatro temporadas de cosecha","resumen":"Si bien existen dos sistemas de iniciación para  el cultivo de espárrago, por arañas y por plantines, sólo el  primero permite iniciar la plantación definitiva en el primer  año. A fin de determinar la incidencia del tamaño de plantín  durante los primeros seis años desde la plantación, se inició  un ensayo el 21 de agosto de 2002, con tres tamaños  de celda: PG: grande, PM: mediana y PCH: chica (70, 50  y 20 cm3   respectivamente), y dos densidades: D1:35,714  y D2:17,857 pl ha-1, empleando el híbrido UC-157 y evaluando  su productividad en el período 2005-2008. Se determinó:  peso fresco por cosecha (PFC) y total anual por ha  (PFT), número de turiones por cosecha (NTC) y por ha (NT)  y peso promedio por turión (PPT). La PFT total 2005-2008  fue 26.300 Kg ha-1 y NT, con un promedio anual de 6,575  kg ha-1 y 480,180 turiones respectivamente. NT mostró una  tendencia creciente a lo largo de todo el período de estudio  mientras que PFT fue creciente en 2005?2007, disminuyendo  en 2008, debido al menor PPT, ocasionado, posiblemente,  por competencia intraespecífica. PM permitió lograr  el mayor rendimiento PFC: 343 kg ha-1. El PPT promedio  del período fue 14 g. D1 logró el máximo rendimiento a lo  largo de todo el período evaluado. Puede concluirse que,  cuando el objetivo es obtener elevada productividad inicial,  convendría utilizar plantines de tamaño de celda superior  a 100 cm3   y que la elección de la densidad es un factor  importante, debido a que existiría una relación directa entre  el marco de plantación utilizado y la productividad lograda","palabras_clave":"RENDIMIENTO|TURIONES|CALIDAD|COSECHA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39801,"idioma_id":5,"titulo":"Evaluación sensorial de diferentes híbridos masculinos de espárrago (Asparagus officinalis) verde","resumen":"El espárrago es una hortaliza delicada, con tendencia creciente a nivel global. Existen diferentes genotipos  cuyas características deben ser evaluadas para determinar los más adaptados al gusto de los consumidores;  fundamentalmente en países como Argentina, en los que es necesario el reposicionamiento de la misma. Se  efectuó una evaluación sensorial de híbridos de espárrago (ensayo de tipo exploratorio), en la Facultad de  Ciencias Agrarias, UCA, con 16 jueces no entrenados. Se evaluaron: Italo, Zeno, Eros, Ercole, H668, Marte,  y Giove, masculinos de origen italiano, y UC 157 de origen americano. Una vez cosechados los turiones,  fueron procesados en base al protocolo argentino de calidad para espárrago verde, cortados a 20 cm, cocidos  y separados en dos partes (punta y base). Se estudiaron: agradabilidad olfativa (AO), agradabilidad visual  general (AV); intensidad de color (AV-IC), apertura puntas (AV-AP), estructura general (AV-E), agradabilidad  gustativa (AG), consistencia pulpa (AG-CP), fibrosidad (AG-F), intensidad de sabor (AG-IS) y juicio general  (JG). En AO se destacaron: Italo, UC 157, H668, Marte; en AV: Italo, Marte y UC 157, Giove y Eros; en AG:  Marte, seguido del resto excepto Ercole; en AV-IC: Eros, Marte y UC 157; en AV-AP: Giove y H668; en AV-E:  Italo, H668, Marte, Zeno, UC 157; en AG-IS: Marte y UC157, Ercole, Giove, Italo y Eros; en AG-CP: Marte,  los restantes excepto Ercole. Los menos fibrosos resultaron: H668 y Giove. En JG superaron la media de 6,7,  Marte, Italo y UC 157","palabras_clave":"CALIDAD|PERCEPCIÓN|TURIONES|AGRADABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39802,"idioma_id":4,"titulo":"Analysis of large-scale spatio-temporal trends of Ostrea puelchana beds in Northern Patagonian gulfs, Argentina","resumen":"Wild oyster populations have declined severely worldwide, however fluctuations of South Atlantic populations are poorly documented. We explored the changes in the abundance of Ostrea puelchana population of Northern Patagonia, Argentina, by linking data from palaeontological, archaeological and informal sources, with time series data from fishing, ecological and studies of oyster pathology.  The focal area for this study is the San Matías Gulf (SMG, 40° 50´ to 42° 15´ S, 63° 5? to 65° 10´ W). Populations of O. puelchana were inferred from sub-fossil deposits (>700 years ago) throughout the gulf, but were documented in surveys a century ago only in the NW coast. More recently, new populations have established in the NE and southern regions of the gulf. We proposed that the O.puelchana populations of the NW of the SMG have declined as a consequence of epizootic infections by Bonamia exitiosa while populations of the NE of the gulf have expanded and increased apparently not influenced by dredge activities.  Dredge fisheries for scallops took place in the 1970s and 1980s on the NE coast of the gulf but had a low impact on oyster beds. Coincident with epizootic infections by B. exitiosa and other possible local causes, oyster populations in the northwestern region declined after 1996.   The southward expansion of oyster population at latitudes beyond the historical distribution range might reflect long-term adequate environmental conditions for larval survival on the NE and S of the SMG. On the other hand, oyster population contraction pattern on the NW coast of the gulf occurred at smaller spatial and temporal scale and was caused by local factors.","palabras_clave":"CONTRACTION|EXPANSION|EPIZOOTY|OYSTER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39803,"idioma_id":4,"titulo":"Interacting proteins of protein kinase A regulatory subunit in  Saccharomyces cerevisiae","resumen":"ABSTRACT  28  29 cAMP-dependent protein kinase mediates many extracellular signals in eukaryotes. The  30 compartmentalization of PKA is an important level of control of the specificity of signal  31 transduction mediated by cAMP. Unlike mammalian PKA for which proof insights in  32 the mechanism that controls its localization through anchoring proteins (AKAPs) has  33 been obtained, in the case of Saccharomyces cerevisiae PKA there was little  34 information available. In this work, we present results that demonstrate the isolation and  35 identification of yeast PKA regulatory subunit (Bcy1) associated proteins using a MS36  based proteomic analysis and a bioinformatic approach. The verification of some of  37 these interactions was assessed by immunoprecipitation, pull down and co-localization  38 by subcellular fractionation. The key role of positively charged residues present in the  39 interaction domain of the identified proteins was demonstrated. The defined interaction  40 domain has therefore different molecular characteristics than conventional AKAP  41 domains. Finally we assess initial experiments to visualize the physiological relevance  42 of the interaction of both Ira2 and Hsp60 with Bcy1. Bcy1 interacts with Ira2 tethering  43 PKA to the Ras complex and Hsp60 chaperone localizes PKA to mitochondria and has a  44 role in the kinase stability.","palabras_clave":"PKA|Saccharomyces cerevisiae|AKAPs|Specificity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39804,"idioma_id":4,"titulo":"Hydrogen sorption properties of mechanically alloyed Mg1\u00022xFexTix powder mixtures","resumen":"We report an investigation on the hydrogen sorption properties of mechanically alloyed systems of nominal composition Mg12xFexTix (x = 0.10, 0.15 and 0.20). The starting metallic powder mixtures were milled in H2 ambient, till a steady state with no further H2 absorption was attained. The resulting samples were then characterized and submitted to several H2 discharge?charge cycles in order to determine their hydrogen sorption properties. With the aim to investigate the dependence of these properties on the sample microstructure we also studied samples of nominal composition Mg80Fe10Ti10 obtained through different processing routes. In those samples the Fe and Ti additives were added as a fine powder mixture or as the intermetallic compound FeTi while their mechanical alloying with Mg was conducted under H2 or Ar atmosphere. All the samples were characterized by X-ray diffraction and Mössbauer spectroscopy on 57Fe, before and after their cycling in H2. The results are analyzed in the framework of possible mechanisms for the transition metals catalytic action on the H2 sorption processes and the influence of the sample microstructure.","palabras_clave":"Metallic hydrides|Hydrogen storage|Mechanical alloying|Mössbauer spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39805,"idioma_id":4,"titulo":"An Approach for Automating Use Case Refactoring","resumen":"Carrying out requirements capture and modeling activities successfully is not easy, often requiring a thoughtful analysis of clients needs and demanding an adequate expertise from analysts. To ensure a fluid communication among stakeholders, analysts must take advantage of modeling techniques while describing requirements and exploit reuse and abstraction practices so as to avoid redundancy (for instance, using relations between use cases). Unfortunately, these practices are seldom applied because inspecting requirements such as textual use cases by hand, looking out for faulty or duplicate functionalities, is a challenging and error-prone activity. In this context, we introduce an assistive approach called ReUse that searches redundancy eficiencies in use case specifications and allows to fix them with relation-based refactorings. Our approach makes use of text processing and sequence alignment techniques to discover deficiencies (e.g., duplicate functionality). We have evaluated ReUse in five case studies, achieving promising results.","palabras_clave":"USE CASE REFACTORING|SEQUENCE ALIGNMENT|REQUIREMENT DEFECT|DOMAIN CLASSIFICATION|REQUIREMENTS ENGINEERING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39806,"idioma_id":4,"titulo":"Leptin is an anti-apoptotic effector in placental cells involving p53 downregulation","resumen":"            Leptin, a peripheral signal synthetized by the adipocyte to regulate energy metabolism, can also be produced by placenta,            where it may work as an autocrine hormone. We have previously demonstrated that leptin promotes proliferation and            survival of trophoblastic cells. In the present work, we aimed to study the molecular mechanisms that mediate the survival            effect of leptin in placenta. We used the human placenta choriocarcinoma BeWo and first trimester Swan-71 cell lines, as            well as human placental explants. We tested the late phase of apoptosis, triggered by serum deprivation, by studying the            activation of Caspase-3 and DNA fragmentation. Recombinant human leptin added to BeWo cell line and human placental            explants, showed a decrease on Caspase-3 activation. These effects were dose dependent. Maximal effect was achieved at            250 ng leptin\/ml. Moreover, inhibition of endogenous leptin expression with 2 mM of an antisense oligonucleotide, reversed            Caspase-3 diminution. We also found that the cleavage of Poly [ADP-ribose] polymerase-1 (PARP-1) was diminished in the            presence of leptin. We analyzed the presence of low DNA fragments, products from apoptotic DNA cleavage. Placental            explants cultivated in the absence of serum in the culture media increased the apoptotic cleavage of DNA and this effect            was prevented by the addition of 100 ng leptin\/ml. Taken together these results reinforce the survival effect exerted by            leptin on placental cells. To improve the understanding of leptin mechanism in regulating the process of apoptosis we            determined the expression of different intermediaries in the apoptosis cascade. We found that under serum deprivation            conditions, leptin increased the anti-apoptotic BCL-2 protein expression, while downregulated the pro-apoptotic BAX and            BID proteins expression in Swan-71 cells and placental explants. In both models leptin augmented BCL-2\/BAX ratio.            Moreover we have demonstrated that p53, one of the key cell cycle-signaling proteins, is downregulated in the presence of            leptin under serum deprivation. On the other hand, we determined that leptin reduced the phosphorylation of Ser-46 p53            that plays a pivotal role for apoptotic signaling by p53. Our data suggest that the observed anti-apoptotic effect of leptin in            placenta is in part mediated by the p53 pathway. In conclusion, we provide evidence that demonstrates that leptin is a            trophic factor for trophoblastic cells.","palabras_clave":"leptina|p53|apoptosis|placenta"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39807,"idioma_id":4,"titulo":"Comments on 'A Closed-Form Solution to Tensor Voting: Theory and Applications'","resumen":"We comment on a paper that describes a closed-form formulation to Tensor Voting, a technique to perceptually group  clouds of points, usually applied to infer features in images. The authors proved an analytic solution to the technique, a highly relevant  contribution considering that the original formulation required numerical integration, a time-consuming task. Their work constitutes the  first closed-form expression for the Tensor Voting framework.  In this work we first observe that the proposed formulation leads to unexpected results which do not satisfy the constraints for a Tensor Voting output, hence they cannot be interpreted. Given that the closed-form expression is said to be an analytic equivalent solution, unexpected outputs should not be encountered unless there are flaws in the proof. We analyzed the underlying math to find which were the causes of these unexpected results.  In this commentary we show that their proposal does not in fact provide a proper analytic solution to Tensor Voting and we indicate the flaws in the proof.","palabras_clave":"Tensor Voting|perceptual grouping|feature inference"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39808,"idioma_id":4,"titulo":"Perceptual Grouping by Tensor Voting: A Comparative Survey of Recent Approaches","resumen":"Tensor Voting is a computational framework that addresses the problem of perceptual organization. It was designed to convey human perception principles into a unified framework that can be adapted to extract visually salient elements from possibly noisy or corrupted images.  The original formulation featured some concerns that made it difficult or impractical to be applied directly. Therefore, several partial or total theoretical reformulations or augmentations have been proposed. These almost parallel publication were presented in di\u000Bfferent directions, with diff\u000Berent priorities and even in a diff\u000Berent notation. Thus, we observed the need for a coherent description and comparison of the diff\u000Berent proposals.  This work, after describing the original approach of Tensor Voting, reviews and explains a number of high impact theoretical modications in a self-contained manner and including possible future directions of work.  We have selected and organized a number of formulations and unied the way the problem is addressed across the different proposals. In addition we provide a theoretical comparison intended to be a reference guide at the time of selecting a formulation to solve a particular problem.  The aim of this paper is to contribute with a modern comprehensive source of information on the theoretical aspects of Tensor Voting. We also show diff\u000Berent ways in which traditional computer vision problems have been adapted to be solved applying this technique.","palabras_clave":"Tensor Voting|Perceptual grouping|Feature extraction|Noisy images"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39809,"idioma_id":5,"titulo":"Enseñanza en medicina de la metodología del diagnostico clínico en pequeños grupos con interacción pautada","resumen":"El mejor scenario para la enseñanza del método de diagnóstico  clinico es utilizando pequeños grupos, situación con gran aceptación tanto en  docentes como en estudiantes. Aún siendo considerado el entrono ideal de  trabajo, tiene algunos aspectos que deben ser tenidos en cuenta para alcanzar  los objetivos. Este trabajo fue realizado para promover una propuesta de  trabajo en la dinámica de dos grupos y comparar los resultados en términos  de análisis cualtitativo y cuantitativos. Sesenta y dos estudiantes se  incluyeron en el grupo control y setenta y cuatro en el grupo experimental.  Todos debían estar cursando el 4° año de la Carrera de Medicina entre los  años 2010 y 2012. Los dos grupos se compararon no solo en la  autoevaluación y satisfacción de los estudiantes, sino también en una  evaluación continua individual, grupal y escrita individual. La comparación  entre grupos fue estadisticamente significativa al comienzo del trabajo en  terminus cuantitativos mientras no lo fue al finalizar el mismo. Con respecto  a la participación de los estudiantes hubo diferencia en favor del grupo  experimental (p<0,001). La sistematización en la interacción en pequeños  grupos es posiblemente la modalidad más adecuada para la incorporación de  competencias debido al mayor compromiso y motivación de los estudiantes.","palabras_clave":"Enseñanza en pequeños grupos |aprendizaje basado en casos|método diagnostic|diagnostic clínico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39810,"idioma_id":4,"titulo":"Expanding the chemical diversity of natural esters by engineering a polyketide-derived pathway into Escherichia coli","resumen":"Microbial fatty acid (FA)-derived molecules have emerged as promising alternatives to petroleum-based chemicals for reducing dependence on fossil hydrocarbons. However, native FA biosynthetic pathways often yield limited structural diversity, and therefore restricted physicochemical properties, of the end products by providing only a limited variety of usually linear hydrocarbons. Here we have engineered into Escherichia coli a mycocerosic polyketide synthase-based biosynthetic pathway from Mycobacterium tuberculosis and redefined its biological role towards the production of multi-methyl-branched-esters (MBEs) with novel chemical structures. Expression of FadD28, Mas and PapA5 enzymes enabled the biosynthesis of multi-methyl-branched-FA and their further esterification to an alcohol. The high substrate tolerance of these enzymes towards different FA and alcohol moieties resulted in the biosynthesis of a broad range of MBE. Further metabolic engineering of the MBE producer strain coupled this system to long-chain-alcohol biosynthetic pathways resulting in de novo production of branched wax esters following addition of only propionate.","palabras_clave":"Branched fatty acid|Mycocerosic acid|Lipid metabolism|Polyketide-derived molecules"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39811,"idioma_id":5,"titulo":"Las denuncias de los afiliados de las empresas de medicina prepaga presentadas ante la Subsecretaría de Defensa del Consumidor en Argentina, 2000-2008","resumen":"El trabajo analiza los problemas de los afiliados a las empresas de medicina prepaga en Argentina cuando las mismas incumplen con la Ley de Defensa del Consumidor. El universo de estudio se conformó por las denuncias de los afiliados durante los años 2000-2008, ante la Subsecretaría de Defensa del Consumidor de la Nación, y por las disposiciones y laudos emitidos por la misma. Un aspecto conclusivo es la recurrencia de los incumplimientos en las prestaciones del Programa Médico Obligatorio y los argumentos expuestos por las empresas, centrados en la responsabilización de los afiliados. Se advierte que la falta de un sistema de información a nivel nacional impide la realización de estudios empíricos que reflejen adecuadamente el problema. La discusión se realiza a partir de estudios sobre los seguros privados de salud en otros países de la región. Sobre ello se observa la importancia de estudiar a las empresas de medicina prepaga, su articulación con el sistema de salud, y los procesos de limitación y negación de la ciudadanía, así como la creciente judicialización de la salud.","palabras_clave":"Sistemas Prepagos de Salud|Legislación &  Jurispridencia|Defensa del Consumidor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39812,"idioma_id":4,"titulo":"Growth, abundance, morphometric and metabolic parameters of three populations of Diplodon chilensis subject to different levels of natural and anthropogenic organic matter input in a glaciar lake of North Patagonia","resumen":"Three populations of Diplodon chilensis (Hiridae, Bivalvia) from North Patagonia (Lacar lake, Argentina) have been studied to determine how organic matter (OM) influence their growth, density, morphometric and metabolic parameters in two pristine sites (Yuco and Nonthué) and in a growing touristic locality (San Martín de los Andes Bay, site SMA) affected by urban discharges. In Nonthué (chemical and biological oxygen demand ratio COD\/BOD ratio of 4.7), a dense neighboring forest provides higher quantities of vegetal detritus compared to Yuco, while in SMA the OM input increase is related to anthropogenic impact, mainly sewage discharges, which is more biodegradable (COD\/BOD ratio of 1.7). Our results show that population?s size distribution and growth rates are affected positively by increased OM, independently of its natural or anthropogenic origin. The modal shell length interval for SMA and Nonthué is two-fold higher (70 mm), in agreement to the growth rate increase (k=0.079), compared to Yuco (35 mm, k=0.045). The morphometric relationships between size-size and size-mass show a higher slope for SMA and Nonthué, which underline allometric differences between these two populations and the Yuco?s one. The lower population densities in both sites (SMA 33 ind.\/m2 and Nonthue 76 ind.\/m2) compare to Yuco (176 ind.\/m2) and the absence of individuals younger than 7 and 5 years old, respectively, in SMA and Nonthué could be related to the higher allochthonous OM content in the sediments and total suspended solids in water. Increased OM due to urban pollution in SMA bivalves leads to higher oxidative damage to lipids, which is not counterbalanced by the higher detoxification enzyme glutathione-S-transferase activity. Hence, we can conclude that pollution would explain the drastic reduction in population density, probably related to a high impair in the juvenile?s survival\/recruitment, the higher observed mortality and the lower population longevity. When increased OM is supply by the forest, like in Nonthue, this has less negative effect on population density and no effect on longevity at all. However, a negative effect of oxygen depletion due to increased OM (either anthropogenic or natural) on juvenile survival cannot be discarded, but further studies should be carried out to support this idea.","palabras_clave":"Freshwater bivalves|Growth rates |Population parameters|Allochthonous organic matter |Anthropogenic impact"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39813,"idioma_id":4,"titulo":"Antioxidant activity of amaranth protein hydrolysate against thermal oxidation of vegetable oils","resumen":"The antioxidant capacity of amaranth protein hydrolysate (AH) during the thermal induced oxidation of two different vegetable oils, sunflower oil (SO) and canola oil (CO), was assessed by differential scanning calorimetry (DSC) by means of isothermal and non-isothermal assays. Interactions between AH and tocopherols were also analyzed. In both oils, AH (10 % w\/w) produced an increase of the induction period (IP) in isothermal assays, presenting a synergistic effect with tocopherols.  In the case of non-isothermal assays, thermograms of oils with AH showed a significant diminution in the second exothermic peak, suggesting an inhibition of the decomposition of primary to secondary oxidation products. In addition, AH produced an increase in the oxidation rate constant (k) value at low temperatures being more evident in the case of canola oil. However, this effect decreased as a function of the temperature increase, which suggests that AH would have a pro-oxidant effect at low temperatures but an heat stabilizing effect at high temperatures (above 210 °C for SO and 190 °C for CO).","palabras_clave":"amaranth|protein hydrolysates |antioxidant activity|thermal oxidation|differential scanning calorimetry (DSC)"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39814,"idioma_id":4,"titulo":"Characterization of Rhizobium grahamii extrachromosomal replicons and their transfer among rhizobia","resumen":"BACKGROUND: Rhizobium grahamii belongs to a new phylogenetic group of rhizobia together with Rhizobium mesoamericanum and other species. R. grahamii has a broad-host-range that includes Leucaena leucocephala and Phaseolus vulgaris, although it is a poor competitor for P. vulgaris nodulation in the presence of Rhizobium etli or Rhizobium phaseoli strains. This work analyzed the genome sequence and transfer properties of R. grahamii plasmids. RESULTS: Genome sequence was obtained from R. grahamii CCGE502 type strain isolated from Dalea leporina in Mexico. The CCGE502 genome comprises one chromosome and two extrachromosomal replicons (ERs), pRgrCCGE502a and pRgrCCGE502b. Additionally, a plasmid integrated in the CCGE502 chromosome was found. The genomic comparison of ERs from this group showed that gene content is more variable than average nucleotide identity (ANI). Well conserved nod and nif genes were found in R. grahamii and R. mesoamericanum with some differences. R. phaseoli Ch24-10 genes expressed in bacterial cells in roots were found to be conserved in pRgrCCGE502b. Regarding conjugative transfer we were unable to transfer the R. grahamii CCGE502 symbiotic plasmid and its megaplasmid to other rhizobial hosts but we could transfer the symbiotic plasmid to Agrobacterium tumefaciens with transfer dependent on homoserine lactones. CONCLUSION: Variable degrees of nucleotide identity and gene content conservation were found among the different R. grahamii CCGE502 replicons in comparison to R. mesoamericanum genomes. The extrachromosomal replicons from R. grahamii were more similar to those found in phylogenetically related Rhizobium species. However, limited similarities of R. grahamii CCGE502 symbiotic plasmid and megaplasmid were observed in other more distant Rhizobium species. The set of conserved genes in R. grahamii comprises some of those that are highly expressed in R. phaseoli on plant roots, suggesting that they play an important role in root colonization.","palabras_clave":"Rhizobium grahamii|genomic analysis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39815,"idioma_id":4,"titulo":"Benefits of soil carbon: report on the outcomes of an international scientific committee on problems of the environment rapid assessment workshop","resumen":"A Scientific Committee on Problems of the Environment Rapid Assessment (SCOPE-RAP) workshop was heldon 18?22 March 2013. This workshop was hosted by the European Commission, JRC Centre at Ispra, Italy, andbrought together 40 leading experts from Africa, Asia, Europe and North and South America to create foursynthesis chapters aimed at identifying knowledge gaps, research requirements, and policy innovations. Thisreport provides an update on the global societal challenge of soil carbon management and some of the mainissues and solutions that were identified in the working sessions. Given the forthcoming publication by CABIof a book volume of the outcomes of the SCOPE-RAP in 2014, this workshop report provides an update on theglobal societal challenge of soil carbon management and some of the main issues and solutions that wereidentified in the four working sessions.","palabras_clave":"CLIMATE CHANGE|LAND USE CHANGE|ECOSYSTEM SERVICES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39816,"idioma_id":4,"titulo":"Rhizobial plasmid pLPU83a is able to switch between different transfer machineries depending on its genomic background","resumen":"Plasmids have played a major role in bacterial evolution, mainly by   their capacity to perform horizontal gene transfer (HGT). Their   conjugative transfer (CT) properties are usually described in terms of   the plasmid itself. In this work, we analyzed structural and functional   aspects of the CT of pLPU83a, an accessory replicon from Rhizobium sp. LPU83, able to transfer from its parental strain, from Ensifer meliloti, or from Rhizobium   etli. pLPU83a contains a complete set of transfer genes, featuring a   particular organization, shared with only two other rhizobial plasmids.   These plasmids contain a TraR quorum-sensing (QS) transcriptional   regulator, but lack an acyl-homoserine lactone (AHL) synthase gene. We   also determined that the ability of pLPU83a to transfer from R. etli   CFN42 genomic background was mainly achieved through mobilization,   employing the machinery of the endogenous plasmid pRetCFN42a, falling   under control of the QS regulators from pRetCFN42a. In contrast, from   its native or from the E. meliloti background, pLPU83a utilized its own   machinery for conjugation, requiring the plasmid-encoded traR.   Activation of TraR seemed to be AHL independent. The results obtained   indicate that the CT phenotype of a plasmid is dictated not only by the   genes it carries, but by their interaction with its genomic context.","palabras_clave":"plasmid|rhizobium"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39817,"idioma_id":4,"titulo":"Evolution and natural selection: learning by playing and reflecting","resumen":"Scientific literacy is more than the simple reproduction of traditional school science knowledge and requires a set of skills, among them identifying scientific issues, explaining phenomena scientifically and using scientific evidence. Several studies have indicated that playing computer games in the classroom can support the development of students? conceptual understanding about scientific phenomena and theories.  Our paper presents a research study where the role of the video game Spore as a learning tool was analysed in a Biology class. An ethnographical perspective served as the framework for the organization and development of a workshop comprised of five sessions with 22 4th grade students, and their Biology teacher.  The results show that this video game could become an interesting learning tool to improve students? understanding of evolution and natural selection. The students could combine their previous knowledge with the academic knowledge obtained though the simulation presented by the video game.  To sum up, an attempt has been made to give some empirical guidance about effective approaches to the utilisation of games in classrooms, additionally paying attention to a number of concerns related to the effectiveness of video games as learning tools.","palabras_clave":"COMPUTER GAMES|SCIENCE EDUCATION|ETHNOGRAPHY|SECONDARY EDUCATION|LEARNING STRATEGIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39818,"idioma_id":4,"titulo":"A Novel light-dependent activation of DAGK and PKC in Bovine  Photoreceptor Nuclei","resumen":"In this work, we describe a selective light-dependent distribution of the lipid kinase 1,2-diacylglycerol kinase (EC 2.7.1.107, DAGK) and the phosphorylated protein kinase C alpha (pPKCalpha) in a nuclear fraction of photoreceptor cells from bovine retinas. A nuclear fraction enriched in small nuclei from photoreceptor cells (PNF), was obtained when a modified nuclear isolation protocol developed by our laboratory was used. We measured and compared DAGK activity as phosphatidic acid (PA) formation in PNF obtained from retinas exposed to light and in retinas kept in darkness using  [gamma-32P]ATP or [3H]DAG. In the absence of exogenous substrates and detergents, no changes in DAGK activity were observed. However, when DAGK activity assays were performed in the presence of exogenous substrates, such as stearoyl arachidonoyl glycerol (SAG) or dioleoyl glycerol (DOG), and different detergents (used to make different DAGK isoforms evident), we observed significant light effects on DAGK activity, suggesting the presence of several DAGK isoforms in PNF. Under conditions favoring DAGKzeta activity (DOG, Triton X-100, dioleoyl phosphatidylserine and R59022) we observed an increase in PA formation in PNF from retinas exposed to light with respect to those exposed to darkness. In contrast, under conditions favoring DAGKepsilon (SAG, octylglucoside and R59022) we observed a decrease in its activity. These results suggest different physiological roles of the above-mentioned DAGK isoforms. Western blot analysis showed that whereas light stimulation of bovine retinas increases DAGKzeta nuclear content, it decreases DAGKepsilon and DAGKbeta content in PNF. The role of PIP2-phospholipase C in light-stimulated DAGK activity was demonstrated using U73122. Light was also observed to induce enhanced pPKCalpha content in PNF. The selective distribution of DAGKzeta and epsilon in PNF could be a light-dependent mechanism that in vertebrate retina promotes selective DAG removal and PKC regulation.","palabras_clave":"DIACYLGLYCEROL KINASE|PROTEIN KINASE C|BOVINE PHOTORECEPTOR NUCLEI|LIGHT-DEPENDENT DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39819,"idioma_id":5,"titulo":"CLASIFICACIÓN DE LA EPILEPSIA Y SÍNDROMES EPILÉPTICOS: UNA TAREA PENDIENTE  PARA LA MEDICINA VETERINARIA","resumen":"En la actualidad no existe una terminología universalmente aceptada en epileptología veterinaria, motivopor el cual se suelen aplicar los conceptos emitidos por la Liga Internacional contra la Epilepsia. Clasificarlos síndromes epilépticos es imprescindible para unificar criterios, agrupar los trastornos convulsivos, generarestadísticas, marcar tendencias generales y particulares, y comparar estudios epidemiológicos. En MedicinaHumana, las clasificaciones vigentes se encuentran en una fase de reconsideración de los conceptos clásicos, ytodavía no están instalados en la comunidad científica.La gran dificultad de la Medicina Veterinaria radica en el diagnóstico. Los trastornos epilépticos de losperros y gatos son similares a los de los humanos, y es posible que se puedan aplicar los mismos criterios declasificación. Para lograrlo se debe elaborar una detallada descripción de las crisis epilépticas, realizada porneurólogos expertos, y un entrenamiento adicional de los veterinarios no especialistas que facilite un diagnósticoexacto. También es imprescindible la disponibilidad de herramientas diagnósticas adecuadas, como elelectroencefalograma o las imágenes sofisticadas, que permitan la diferenciación entre crisis epilépticas y noepilépticas y el reconocimiento de patologías estructurales. No es una tarea sencilla, y elaborar una clasificaciónadecuada puede resultar un trabajo arduo que implica necesariamente un trabajo multicéntrico y consensuado.Pero es imprescindible trabajar en ello para poder unificar criterios y poder comparar experiencias","palabras_clave":"EPILEPSIA|SINDROMES EPILEPTICOS|CLASIFICACION|MEDICINA VETERINARIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39820,"idioma_id":4,"titulo":"Social Influence in Group Recommender Systems","resumen":"Structured Abstract:  Purpose: This paper proposes an approach to generate recommendations for groups on the basis of social factors extracted from a social network. Group recommendation techniques traditionally assumed users as independent individuals, ignoring the effects of social interaction and relationships among users. In this work we analyze those social factors, available in social networks, in the light of sociological theories, which endorse individuals? influenceability within a group.    Design\/methodology\/approach: The approach proposed is based on the creation of a group model in two stages: identifying the items representative of the majority?s preferences, analyzing members? similarity; extracting potential influence from members? interaction in social network to predict a group?s opinion for each item.    Findings: The promising results obtained when evaluating the approach on the movie domain, support that individual opinions tend to be accommodated to group satisfaction, evidencing the incidence of the aforementioned factors in collective behavior, as endorsed by sociological research. What is more, findings suggest that these factors have dissimilar impact on group satisfaction.  Originality\/value: The results obtained provide clues about how social influence exerted within groups could alter individuals? opinions when a group has a common goal. There is limited research in this area exploring social influence in group recommendation; thus, the originality of this perspective lies in the use of sociological theoretical basis to explain social influence in groups of users, and the flexibility of the approach to be applied in any domain. Our findings could be helpful for group recommender systems developers both at research and commercial levels.","palabras_clave":"social influence|group recommendation|social recommendation|online social networks"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39821,"idioma_id":4,"titulo":"Easy Gesture Recognition for Kinect","resumen":"Recent progress in entertainment and gaming systems has brought more natural and intuitive human-computer interfaces to our  lives. Innovative technologies, such as Xbox Kinect, enable the recognition of body gestures, which are a direct and expressive  way of human communication. Although current development toolkits provide support to identify the position of several joints of  the human body and to process the movements of the body parts, they actually lack a flexible and robust mechanism to perform  high-level gesture recognition. In consequence, developers are still left with the time-consuming and tedious task of recognizing  gestures by explicitly defining a set of conditions on the joint positions and movements of the body parts. This paper presents  EasyGR (Easy Gesture Recognition), a tool based on machine learning algorithms that help to reduce the effort involved in gesture  recognition. We evaluated EasyGR in the development of 7 gestures, involving 10 developers. We compared time consumed, code  size, and the achieved quality of the developed gesture recognizers, with and without the support of EasyGR. The results have  shown that our approach is practical and reduces the effort involved in implementing gesture recognizers with Kinect.","palabras_clave":"Natural User Interfaces|Gesture Recognition|Machine Learning|Kinect"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39822,"idioma_id":4,"titulo":"Water decontamination by silver and copper montmorillonite","resumen":"Several bactericide inorganic materials have been used for the  purification of water with varying success. The characterisation of the  incorporation of Ag or Cu cations in montmorillonite (MMT) clay, to obtain a  bactericide material against E. coli, indicated that both outer and interlayer  surfaces act as adsorption sites of AgO and Ag2O or CuO, respectively. The  Ag-exchanged clays retain their bactericide ability even after being stirred in  aqueous suspension, whereas samples with the highest concentration of Cu do  not inhibit bacterial growth. Experiences from supernatants of Cu-exchanged  clays indicated that bactericide capacity was present at high clay concentration.","palabras_clave":"silver montmorillonite|copper montmorillonite|bactericidal effect"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39823,"idioma_id":4,"titulo":"Synthesis, characterization and catalytic properties of cationic hydrogels containing copper(II) and cobalt(II) ions","resumen":"Here, we report the synthesis and characterization of a hydrogel based   on ethylene glycol diglycidyl ether (EGDE) and   1,8-diamino-3,6-dioxaoctane (DA). Chemically stable Co(II) and Cu(II)   coordination complexes were prepared with this nonsoluble   polyelectrolyte, poly(EGDE-DA), and studied by ss-NMR,   FT-IR, thermogravimetry, and microscopy. Mesopores were found in all the   samples, the thermal stability of the polymer matrix was highly   affected by the presence of metal ions, and the 13C CP-MAS   spectrum for the Cu(II)-complex evidenced a significant increase in the   reticulation degree by Cu(II) ions. The catalytic activity of these   materials on H2O2 activation was studied by electron spin resonance (ESR). The Co(II)-poly(EGDE-DA)\/H2O2 heterogeneous system produced O2, an anion superoxide (O2?¯), and a hydroxyl radical (OH?), which diffused into the solution at the time that a decrease in pH was detected. In the same way, the Cu(II)-poly(EGDE-DA)\/H2O2 heterogeneous system produced O2 and OH?. H2O2 activation by the poly(EGDE-DA)   complexes with Co(II) and Cu(II) were applied on the decolorization of   solutions of the azo-dye methyl orange (MO). In the presence of 63 mM H2O2, 87% of MO was removed in 10 min with Cu(II)-poly(EGDE-DA) and in 110 min with Co(II)-poly(EGDE-DA). In addition, the pharmaceutical product epinephrine was partially oxidized to adrenochrome by the O2?¯ released from the Co(II)-poly(EGDE-DA)\/H2O2 heterogeneous system.","palabras_clave":"HETEROGENEOUS CATALYSIS|POLYELECTROLITES|Cu COMPLEXES|Co COMPLEXES|HYDROGEN PEROXIDE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39824,"idioma_id":6,"titulo":"Au temps du Test du crapaud. Justice et avortement ( Argentine, Mi-XX Siécle","resumen":"En este artículo se analizan las relaciones entre justicia, aborto y medicina en los años peronistas en la Argentina.","palabras_clave":"GENERO Y JUSTICIA|PERONISMO|HORMONAS|ABORTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39825,"idioma_id":4,"titulo":"Redox Potential Determines the Reaction Mechanism of HNO Donors with Mn and Fe Porphyrins: Defining the Better Traps","resumen":"Azanone (1HNO, nitroxyl) is a highly reactive  molecule with interesting chemical and biological properties. Like  nitric oxide (NO), its main biologically related targets are oxygen,  thiols, and metalloproteins, particularly heme proteins. As HNO  dimerizes with a rate constant between 106 and 107 M&#8722;1 s&#8722;1, reactive  studies are performed using donors, which are compounds that  spontaneously release HNO in solution. In the present work, we  studied the reaction mechanism and kinetics of two azanone donors   Salt and toluene sulfohydroxamic acid (TSHA) with eight  Angelis  different Mn porphyrins as trapping agents. These porphyrins differ in  their total peripheral charge (positively or negatively charged) and in  their MnIII\/MnII reduction potential, showing for each case positive  (oxidizing) and negative (reducing) values. Our results show that the  reduction potential determines the azanone donor reaction mechanism. While oxidizing porphyrins accelerate decomposition of  the donor, reducing porphyrins react with free HNO. Our results also shed light into the donor decomposition mechanism using  ab initio methods and provide a thorough analysis of which MnP are the best candidates for azanone trapping and quantification  experiments.","palabras_clave":"SULFOHYDROXAMIC ACID|PORPHYRINS|TRAPPING AGENTS|AZANONE DONOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39826,"idioma_id":4,"titulo":"Effect of hot air, vacuum and infrared drying methods on quality of rose hip (Rosa rubiginosa) leathers","resumen":"For the development of fruit leathers, a formulation containing rose hip pulp, sucrose and citric acid was used as initial material for the drying process. Three dehydration techniques were tested: forced hot air, infrared and vacuum, all carried out at 60 and 70 °C. All methods led to flexible, translucent fruit leathers at both temperatures. Colour and water activity were not affected by the dehydration method nor by the temperatures tested. Nutritional parameters such as antioxidant capacity (TEAC) and content of phenolic substances were measured. The best retention was achieved with vacuum drying at 60 °C being of 57.5% and 25.1%, respectively. ESEM observations were conducted to assess the effect of drying methods and conditions on microstructure of leathers. Various extents of sucrose crystallisation were inferred from surface images. Cross-sectional micrographs showed that the size of pores was affected by the drying technique but not by temperature in the range studied.","palabras_clave":"Dehydration|infrared drying|rose hip|;acuum drying"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39827,"idioma_id":4,"titulo":"Draft Genome Sequence of the Polyextremophilic Halorubrum sp. Strain AJ67, Isolated from Hyperarsenic Lakes in the Argentinian Puna","resumen":"Halorubrum sp. strain AJ67, an extreme halophilic UV-resistant archaeon, was isolated from Laguna Antofalla in the Argentinian Puna. The draft genome sequence suggests the presence of potent enzyme candidates that are essential for survival under multiple environmental extreme conditions, such as high UV radiation, elevated salinity, and the presence of critical arsenic concentrations.","palabras_clave":"GEnomica|Resistencia Arsenico|Bioinformatica|Secuenciacion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39828,"idioma_id":4,"titulo":"Double-layered rotavirus-like particles are efficient carriers to elicit strong CTL responses to delivered heterologous antigens","resumen":"The first 92 amino acids of VP2 of rotavirus are dispensable for VLP assembly and can be replaced by heterologous reporter proteins without affecting either self-assembly of chimeric VP2 or the interaction with VP6 to render chimeric VP2\/6 VLPs. In this study, we constructed recombinant baculoviruses expressing GFP or OVA fused to the amino terminus of a truncated VP2 sequence and produced chimeric VLPs by co-infection with a baculovirus expressing VP6. The results showed that these chimeric VLPs were efficiently uptaken by murine dendritic cells and that the heterologous sequences contained in the core of these VLPs seemed to be able to reach the MHC-I pathway as they elicited strong and specific CTL responses. Therefore, the data presented here suggest that chimeric VLPs could be used as excellent carriers to elicit CTL responses to antigens transported inside the VLPs. © 2014 Elsevier Ltd. All rights reserved.","palabras_clave":"CTL RESPONSES |HETEROLOGOUS ANTIGENS |ROTAVIRUS-DERIVED DLPS AS CARRIER |VECTOR VACCINE |BACULOVIRUS SYSTEM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39829,"idioma_id":5,"titulo":"Una propuesta metodológica para la determinación de capacidades estratégicas en pymes industriales","resumen":"Una forma para evaluar los problemas internos de las empresas y conocer las fuentes de sus ventajas competitivas, es estudiar sus recursos y capacidades. Los recursos son la base de las capacidades y éstas se pueden desarrollar y transformar en capacidades estratégicas que llevan a la obtención de una  ventaja o igualdad competitiva. En este trabajo se propone una metodología para determinar y valorar las capacidades actuales de pymes industriales de una región argentina para posteriormente conocer su efecto competitivo.  Para ello, se definen cuatro capacidades principales denominadas directiva, innovación, comercialización e integración que a su vez se dividen en subcapacidades compuestas por recursos. Estas capacidades se ponderan, analizan y evalúan para determinar si están presentes en las empresas motivo de estudio. Posteriormente, se hace uso del test VRIO para definir la consecuencia competitiva y distinguir si esas capacidades logran igualdad competitiva o ventajas competitivas temporales o sostenibles.","palabras_clave":"cadena de valor|recursos y capacidades|pymes industriales|ventaja competitiva"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39830,"idioma_id":4,"titulo":"Genetic Structure of Phytophthora capsici populations in the Northeast of Buenos Aires province, Argentina","resumen":"Phytophthora capsici causes destructive diseases worldwide. The pathogen is heterothallic and the two mating types (MTs) are required for sexual reproduction. MTs rates vary amongst geographical regions and so does the chance for sexual reproduction. Taking into account that the durability of control measures depends upon genetic variation, it is advisable to consider the quantity and distribution of genetic variation within and between the species population; the genetic structure. This is determined by factors that influence the population evolution like mutation, genetic drift, genetic flux, reproduction system and selection. In these regards, little is known about P. capsici populations in Argentina. The objective was to evaluate the genetic variability of P. capsici isolates from three horticultural production sites of the Northeast of Buenos Aires. Sixty one isolates of P. capsici collected from Capsicum annuum, Solanum melongena, Solanum lycopersicum and Cucurbita spp. crops were morphologically identified and analyzed for MTs. The isolates were further identified via molecular techniques based on the sequences of the ITS1 - 5.8S - ITS2 region of the ADNr. Los haplotypes were defined for all the isolates. The number and diversity of haplotypes, the number of polymorphic sites and recombination events, and the genetic structure of P. capsici were subsequently estimated. Phylogenetic network reconstruction was assayed using Network 4.6.1.0.All isolates showed morphological and genetic characteristics of P. capsici and belonged to the A1 MT. No differences were observed among isolates from different hosts, but the DNA data showed evidence of recombination and high levels of variability among sites.","palabras_clave":"P. capsici|Cucurbita spp.|Mating type|Haplotype"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39831,"idioma_id":5,"titulo":"Análisis sobre la eficacia de niveles moderados de actividad física para reducir el riesgo de padecer enfermedades cardiovasculares, Un Meta-análisis.","resumen":"Objetivos:             a.Determinar la eficacia de la actividad física en la reducción del riesgo de enfermedades cardiovasculares.         b.Analizar los cambios relativos en los niveles de riesgo a padecer enfermedades cardiovasculares de acuerdo a diferentes intensidades (baja-moderada) de actividad física.              Metodología:        Se realizó un Meta-análisis de los estudios encontrados en la base de datos PUBMED. Se calculó el tamaño del efecto medio y se aplicó el test de Egger para descartar un posible sesgo de publicación. Al detectarse heterogeneidad, se procedió a realizar un análisis de las variables moderadoras.              Resultados:        Se obtuvo un tamaño del efecto medio de 0.762 (0.678-0857; 95% IC). El test de Egger arrojó un p-valor de 0.67 (I.C. 0.95), de manera tal que se confirmó la ausencia de sesgo de publicación. El análisis moderador determinó que los años de seguimiento (p=0.000; 95% IC) y los países de estudio (p=0.0096; 95% IC) son significativos.              Conclusión:      Se puede concluir en que la práctica de actividad física a intensidades moderadas ofrece un efecto protector sobre los individuos que la realizan disminuyendo el riesgo a padecer enfermedades cardiovasculares.","palabras_clave":"META-ANÁLISIS|ENFERMEDADES CARDIOVASCULARES|NIVEL DE ACTIVIDAD FÍSICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39832,"idioma_id":4,"titulo":"Comparison of host cell invasion and proliferation among Neospora caninum isolates obtained from oocysts and from clinical cases of naturally infected dogs","resumen":"In a previous study, we have shown that the in vitro invasion rate (IR) and tachyzoite yield  (TY) are associated with the virulence phenotypes of Neospora caninum isolates of bovine origin. In  addition, we recently observed marked differences in virulence when canine isolates were compared in  a pregnant BALB\/c mouse model. In this study, we investigated whether invasion and proliferation  capacities could be used as virulence-related N. caninum phenotypic traits. Of the isolates compared in  mice, four canine isolates obtained from oocysts (Nc-Ger2, Nc-Ger3, Nc-Ger-6, Nc-6 Arg) had shown a  low-moderate virulence, and two further isolates obtained from dogs with neurological signs (Nc-  Bahia, Nc-Liv) were highly virulent. The IR for each isolate was determined by a plaque assay and the  counting of immunofluorescence-labeled parasitophorous vacuoles at 3 days post-inoculation (p.i.).  The TY was determined by the quantification of tachyzoites at 56 h p.i. by real-time PCR. Most of the  canine isolates showed similar IR values under controlled invasion conditions for 4 h and 72 h p.i.,  indicating a limited time period for invasion similar to that observed for bovine isolates. The Nc-Ger3,  Nc-Bahia, and Nc-Liv isolates showed a significantly higher IR and TY than the Nc-Ger2 and Nc-Ger6  isolates (P0.885, P0.8117, P<0.058)  in mice. These results demonstrate the importance both the invasive and proliferative capacities have  on the virulence of canine N. caninum isolates.","palabras_clave":"Canine Neospora caninum |tachyzoite yield| behavior in vitro|invasion rate|virulence related phenotypic traits"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39833,"idioma_id":5,"titulo":"La teoría de Prebisch-Singer en relación con los términos de  intercambio dentro del sector de commodities agrícolas, período   2001-2008","resumen":"En esta investigación se pretende analizar la tendencia de los términosde intercambio en el período 2001-2008 en referencia a lascommodities agrícolas. A partir del año 2001, la tendencia al deteriorode los términos de intercambio comenzó a modificarse. Esta mejorase debió a factores económicos internacionales como el aumentode la demanda de China e India. Además, el ingreso de especuladoresfinancieros al mercado de commodities influyó notablementeen su precio. En función de esto, la apreciación del tipo de cambioreal es un factor que determinó la mejora de los términos de intercambio.Todos estos factores influyen en parte, en el aumento de losprecios de las commodities agrícolas y en la mejora de sus términosde intercambio en el contexto internacional.","palabras_clave":"TÉRMINOS DE INTERCAMBIO|TIPO DE CAMBIO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39834,"idioma_id":4,"titulo":"Estimating percentiles of bacteriological counts of recreational water quality using Tweedie models","resumen":"p { margin-bottom: 0.25cm; direction: ltr; line-height: 120%; text-align: left; widows: 2; orphans: 2; }a:link { color: rgb(0, 0, 255); }              There  are general guidelines and standards for measuring the microbial  quality of water to prevent the incidence of disease outbreaks. The  last  published  epidemiological studios for recreational waters allowed estimating  the degree of health  protection  or, conversely, the load of disease associated with water quality. To  measurethe  quality ofrecreational  waters,many  agencies havechosenthe95th  percentile.One  can assess therecreationalwater  quality,  depending  if thepercentile  valueexceedsthe  guideline valueor  not. Analyses  of a large data base of historical measurements showed that the data  do not display a normal distribution. Transformations are often  applied so that normality is reestablished, but working with data on  the original scale is more convenient than working with transformed  data. Another alternative is to calculate the nonparametric  percentiles, the disadvantage of calculating these percentiles is  that nonparametric statistics sometimes ignore, waste or lose  information. The most appropriate percentile estimate is obtained by  generating a probability density function based on a  distribution that fits well  the bacteriological counts. A  set of distributions that provides broad possibilities is the Tweedie  family that is a subset of the exponential family and contains the  normal, Poisson, gamma, and inverse Gaussian distributions as  particular cases. We performed a Monte Carlo simulation to compare  the percentiles described above. The  original contribution of this work is that we respected the original  scale of the data and estimated the 95th percentile from the Tweedie  distribution.  It  fits the actual data without transformations.","palabras_clave":"Recreational water quality|95th percentile|Tweedie family|health protection to water quality"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39835,"idioma_id":5,"titulo":"Determinación de propiedades físicas del líquido de cobertura de arvejas enlatadas","resumen":"Las operaciones de enlatados, se basan en dos métodos generales para evitarla destrucción del alimento por microorganismos, siendo estos, la esterilización y la inhibicióno retardo de la actividad de los organismos. Dado que el primero es ampliamenteusado, se decide determinar propiedades físicas, tales como, densidad, viscosidad y tensiónsuperficial, en el líquido de cobertura de arvejas enlatadas para conocer el valor de estaspropiedades físicas, una vez aplicado el proceso de conservación. Las determinacionesse realizaron mediante picnometría, viscosímetro de capilar y estalagmómetro de Traube.","palabras_clave":"CONSERVAS|DENSIDAD|VISCOSIDAD|TENSION SUPERFICIAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39836,"idioma_id":4,"titulo":"Simultaneous correlation architecture for  multilevel complementary sequences","resumen":"Complementary sequences are being widely used in applications  ranging from communication to radar and sonar systems. The properties of these sequences render them suitable for applications requiring  signal detection in noisy environments and\/or multi-user systems. The  use of complementary sequences in practical applications with reduced  hardware resources has promoted the development of efficient architectures that reduce the computational requirements for the generation and  correlation of the sequences. An optimised architecture for the simultaneous correlation of pairs of multilevel complementary sequences  is presented, which achieves that reduction by removing redundant  operations. The proposal has an impact also on the correlation of  binary complementary pairs of sequences of lengths of a power of  10 and 26 that use the multilevel architecture to generate the kernels","palabras_clave":"Complementary Sequences |Correlation|Architectures"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39837,"idioma_id":4,"titulo":"SUMOylation and deimination of proteins: two epigenetic modifications involved in Giardia encystation","resumen":"SUMOylation, a posttranslational modification of proteins, has been recently described as vital in eukaryotic cells. In a previous work, we analyzed the role of SUMO protein and the genes encoding the putative enzymes of the SUMOylation pathway in the parasite Giardia lamblia. Although we observed several SUMOylated proteins, only the enzyme Arginine Deiminase (ADI) was confirmed as a SUMOylated substrate. ADI is involved in the survival of the parasite and, besides its role in ATP production, it also catalyzes the modification of arginine residues to citrulline in the cytoplasmic tail of surface proteins. During encystation, however, ADI translocates to the nuclei and downregulates the expression of the Cyst Wall Protein 2 (CWP2). In this work, we made site-specific mutation of the ADI SUMOylation site (Lys101) and observed that transgenic trophozoites did not translocate to the nuclei at the first steps of encystation but shuttled in the nuclei late during this process through classical nuclear localization signals. Inside the nuclei, ADI acts as a peptidylarginine deiminase, being probably involved in the downregulation of CWPs expression and cyst wall formation. Our results strongly indicate that ADI plays a regulatory role during encystation in which posttranslational modifications of proteins are key players.","palabras_clave":"SUMOYLATION|GIARDIA LAMBLIA|ARGININE DEIMINASE (ADI)|ENCYSTATION|NUCLEAR LOCALIZATION SIGNALS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39838,"idioma_id":4,"titulo":"Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes","resumen":"Although much is described about the molecules involved in neutrophil migration from circulation into tissues, less is known about the molecular mechanisms that regulate neutrophil entry into lymph nodes (LNs) draining a local inflammatory site. In this study, we investigated neutrophil migration toward LNs in a context of inflammation induced by immunization of BALB\/c mice with OVA emulsified in CFA. We demonstrated that neutrophils can enter LNs of OVA\/CFA-immunized mice not only via lymphatic vessels but also from blood, across high endothelial venules. By adoptive transfer experiments, we showed that this influx was dependent on an inflammatory-state condition and previous neutrophil stimulation with OVA\/anti-OVA immune complexes. Importantly, we have demonstrated that, in the migratory pattern to LNs, neutrophils used L-selectin and P-selectin glycoprotein ligand-1, macrophage-1 Ag and LFA-1 integrins, and CXCR4 to get access across high endothelial venules, whereas macrophage-1 Ag, LFA-1, and CXCR4 were involved in their trafficking through afferent lymphatics. Strikingly, we found that stimulation with immune complexes significantly upregulated the expression of sphingosine-1-phosphate receptor 4 on neutrophils, and that treatment with the sphingosine-1-phosphate agonist FTY720 altered neutrophil LN-homing ability. These findings summarized in this article disclose the molecular pattern that controls neutrophil recruitment to LNs.","palabras_clave":"Neutrophils|Draining Lymph Nodes|migration"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39839,"idioma_id":4,"titulo":"Soybean fungal soil-borne diseases: a parameter for measuring the effect of agricultural intensification on soil health","resumen":"The aim of this study was to investigate the influence of agricultural intensification on soil microbial diversity, chemical and physical parameters, and the decrease of the incidence of sudden death syndrome (Fusarium crassistipitatum) and charcoal rot (Macrophomina phaseolina) in soybean. Soils under different management systems were evaluated during 2 crop cycles: soybean monoculture for 24 and 11 years, soybean?maize rotation for 15 and 4 years, 1 year of soybean, and native vegetation. The incidence of both soil-borne diseases was higher under monoculture than under rotation. Increased populations of potential biocontrol agents (Trichoderma spp., Gliocladium spp., fluorescent pseudomonads) were associated with rotation treatments, especially in 2010?2011. The comparison of agricultural vs. native vegetation soil and the average of agricultural cycles showed that microbial biomass carbon and glomalin-related soil protein were higher in the rotation system than in monoculture (50% and 77%, respectively). Furthermore, from the community-level functional diversity (Biolog Eco plates), McIntosh index showed lower functional diversity in monoculture than in rotation and native vegetation plots. Agricultural intensification reduced microbial biomass carbon, glomalin-related soil protein, organic matter, total nitrogen, aggregate stability, and yield, and increased bulk density. Soil quality degradation was associated with the establishment of soil-borne pathogens and increased soybean plant susceptibility to disease.","palabras_clave":"MICROORGANISM|SOIL|INTENSIFICATION|AGRICULTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39840,"idioma_id":4,"titulo":"Quantitative analysis of CKS1B mRNA expression and copy number change in patients with plasma cell disorders","resumen":"n this study, we have examined CKS1B gene expression and copy number in a total of 114- patients at diagnosis: 83 with multiple myeloma (MM) and 31 with monoclonal gammopathy of undetermined significance (MGUS). Results were correlated with cytogenetics, FISH and clinical characteristic. Significant CKS1B mRNA levels in MM compared to MGUS cases (p<0.048) were detected. In MM, the frequency of 1q21 (CKS1B) copy gain was significantly higher in cases with abnormal karyotype compared to patients with normal karyotype (p=0.021). Global analysis showed a positive correlation between CKS1B expression and 1q21 copy number (p<0.0001). No association between CKS1B mRNA expression and clinical parameters was found. However, a significantly higher level of â2 microglobulin in cases with 1q21 gains than those without (p=0.0094) was observed. Overall survival was shorter in cases with 1q21 gain compared to those with normal 1q21 region (p=0.0082). Our results suggest a role for CKS1B in the multiple step process of progression of MGUS to MM and show that CKS1B copy gain has a more significant prognostic value than its overexpression. This adverse impact on survival probably reflects the genetic instability associated to chromosome 1q alterations resulting in a more aggressive behavior of the disease.","palabras_clave":"MULTIPLE MYELOMA|MGUS|CKS1B GENE EXPRESSION|FISH"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39841,"idioma_id":5,"titulo":"El concepto de melancolía en Marsilio Ficino","resumen":"La melancolía como un temperamento asimilado a la tristeza o pesadumbre ha generado en la historia de la filosofía diversos interrogantes que convergen en un mismo problema: ¿Es en el sujeto melancólico donde la capacidad creadora alcanza su máxima expresión?  Nos proponemos en este trabajo desarrollar la respuesta que Marsilio Ficino brindó al respecto en De vita triplici. Si bien no es la única obra en la que da cuenta de la melancolía, elegimos el De vita, específicamente su primer libro Sobre los cuidados de  la salud de quienes se dedican al estudio de las letras, porque consideramos que en ella nuestro autor le dedica mayor atención a las efectos positivos y negativos del estado melancólico. Analizaremos el texto de Ficino tratando de poner de manifiesto la construcción de una doctrina que entiende la melancolía como un estado que provoca una inestabilidad antropológica entre el aspecto físico y el aspecto espiritual del hombre, entre lo voluntario y lo involuntario y, en tal sentido,  nos abocaremos a comprender la relación que establece nuestro autor entre la ?bilis negra?, como se la ha entendido en la Antigüedad, y el planeta Saturno, clave, según Ficino, para vencer un determinismo astrológico mermando sus efectos desfavorables en pos de aquellos provechosos. A lo largo del trabajo buscaremos demostrar que para Ficino, Saturno, como símbolo de la melancolía, influye en los hombres llevándolos a un estado de fervor por la contemplación y, de esta manera, determina al genio creador.  Sin embargo, para alcanzar ese estado es preciso también tomar una serie de medidas terapéuticas que apuntaran al ?cuidado de sí mismo? y que permitieran gozar de los beneficios intelectuales de la melancolía reduciendo las perturbaciones físicas que ella conlleva.","palabras_clave":"Melancolía|Renacimiento|Neoplatonismo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39842,"idioma_id":4,"titulo":"Insights into Embryo Defenses of the Invasive Apple Snail Pomacea canaliculata: Egg Mass Ingestion Affects Rat Intestine Morphology and Growth","resumen":"Background The spread of the invasive snail Pomacea canaliculata is expanding the rat lungworm disease beyond its native range. Their toxic eggs have virtually no predators and unusual defenses including a neurotoxic lectin and a proteinase inhibitor that diminish rat growth rate. We explored the effect of egg perivitellin fluid (PVF) ingestion on the rat small intestine morphophysiology to bring further insight into egg defenses. Methodology\/Principal Findings Through a combination of biochemical, histochemical, histopathological, scanning electron microscopy, cell culture and feeding experiments, we analyzed intestinal morphology, growth rate, hemaglutinating activity, cytotoxicity and cell proliferation after oral administration of PVF to rats. PVF adversely affects small intestine metabolism and morphology and consequently the growth rate, presumably by lectin-like proteins, as suggested by PVF hemaglutinating activity and its cytotoxic effect on CaCo-2 cell culture. Short-term effects of ingested PVF were studied in growing rats. PVF-supplemented diet induced a thickening of the gut wall, the appearance of shorter and wider villi and fused pathological villi. This was associated with changes in glycoconjugate expression, increased cell proliferation at crypt base, and hypertrophic mucosal growth. This resulted in a decreased absorptive surface after 3-day treatment and a diminished rat growth rate that reverted to normal after the fourth day. Longer exposure to the toxic induced a time-dependent lengthening of the small intestine while switching to a control diet restored intestine length and morphology after 4 days. Conclusions\/Significance Ingestion of PVF rapidly limits predator?s ability to absorb egg nutrients of potential predators by inducing large, reversible changes in intestinal morphology and growth rate. The acquisition of toxins that affect intestinal morphology and absorption is a strategy against predation not recognized among animals before. The present study extends to animals plant antipredator defenses acting on the intestine wall of potential predators. This defense mechanism may explain the near absence of predators of apple snail eggs. .http:\/\/www.plosntds.org\/article\/info:doi\/10.1371\/journal.pntd.0002961","palabras_clave":"Snail|egg|embryo defenses|antinutritive"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39843,"idioma_id":5,"titulo":"Internet del Futuro. Desafíos y Perspectivas","resumen":"?Internet del Futuro? es llamada a representar dentro de las Tecnologías de Información y Comunicaciones en un futuro no muy lejano, una batería de conceptos y tecnologías que involucraran a dispositivos, interfaces y software. Desde la Internet de las computadoras, pasando por la Web 2.0, la tendencia es la ubicuidad y fortalecimiento del nuevo paradigma de la computación ?datacentrica?.  En el presente trabajo se analiza la evolución de las tecnologías y conceptos involucrados, fundamentalmente considerando a Internet de las Cosas (IoT), los desafíos e implicancias que conllevan el acceder a ese dominio al cual denominamos Internet del Futuro.  Se concluye que los cambios de paradigmas involucrados envuelven a la sociedad toda, debiendo atenderse los desafíos éticos y tecnológicos a nivel global. Internet de las cosas debe abocarse a mitigar los riesgos en una sociedad donde la información propia debe ser transparente para aquellos actores seleccionados y totalmente invisibles para los demás.","palabras_clave":"Future internet|; Internet of things|Wireless Sensor Networks"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39844,"idioma_id":5,"titulo":"Descontaminación de superficies sólidas mediante cócteles fágicos para prevenir la contaminación cruzada por Escherichia coli enteropatógena y shigatoxigénica","resumen":"El biocontrol de cepas de Escherichia coli enteropatógena (EPEC) y Shigatoxigénica (STEC), causantes de enfermedades trasmitidas por alimentos, mediado por fagos puede ser una herramienta interesante de control para evitar la contaminación cruzada tanto en la industria como en el hogar. Con el objetivo de reducir la contaminación por parte de bacterias patógenas nos propusimos realizar ensayos para evaluar el nivel de biocontrol en medio líquido (challenge en caldo Hershey + MgSO4 5 mM, Hershey-Mg) tanto con fagos individuales como formando parte de un cóctel así como la descontaminación de superficies sólidas, a saber acero inoxidables (AI) (25 mm x 15 mm) y cubreobjetos de vidrio (CV) (18 mm x 18 mm), mediante cócteles fágicos a 4 y 37 ºC. En los challenge se ensayaron 100 µl de fago sobre 5 ml de cultivo bacteriano (DO600nm = 0,1), posteriormente se realizaron recuentos bacterianos a 2, 6 y 24 h. El fago DT1 se ensayó sobre las cepas EPEC920 (eaeA+) (Multiplicidad de infección, MOI = 8,6x101) y STEC O157:H7 (464) (stx2+ y eaeA+) (MOI = 1,4x10exp2), el DT5 sobre STEC no-O157 (ARG4827) (stx1+ y stx2+) (MOI = 2,9x10exp2) y DT6 sobre las tres cepas mencionadas anteriormente a una MOI de 7,8x10exp1, 1,3x10exp2 y 2,6x10exp2, respectivamente. En los ensayos sobre superficies sólidas, las matrices se limpiaron con etanol al 70 % y se autoclavaron. Cada bacteria se inoculó a dos concentraciones, a saber aproximadamente 10exp4 y 10exp6 UFC\/ml para CV y 10exp5 y 10exp7 UFC\/ml para AI, se dejó secar a temperatura ambiente, se aplicó 100 µl del cóctel de fagos (109 UFP\/ml) correspondiente [(DT1 + DT6 para EPEC920 y STEC O157:H7 (464) y DT5 + DT6 para STEC no-O157 (ARG4827)], o caldo Hershey-Mg (control) y se incubó a 4 y 37 ºC durante 1, 3 y 24 h. Pasado el tiempo de incubación, las matrices se procesan para la extracción y recuento de células bacterianas. En los challenge, tanto con fagos individuales como con el cóctel obtuvimos reducciones significativas de células viables y un comportamiento similar para todas las cepas evaluadas a 37 ºC, mientras que a 4 ºC, si bien en la mayoría de los casos se obtuvieron reducciones significativas, éstas fueron pequeñas. En CV y AI el cóctel de fagos inactivó rápida y completamente tanto a la cepa EPEC920 como a STEC O157:H7 (464) a las temperaturas (4 y 37 ºC) y MOI evaluadas. Sin embargo, se observó un recrecimiento cuando se empleo MOI baja para STEC O157:H7 (464) a 4 y 37 ºC en CV y AI, respectivamente, así como para EPEC920 a 37 ºC a ambos valores de MOI empleados. En CV, STEC no-O157 (ARG4827) fue significativamente reducida por el cóctel solo a las primeras horas del ensayo tanto a 5 como a 37 ºC, sin embargo, no se obtuvo una inactivación total del patógeno y se observó un recrecimiento a 37 ºC. Contrariamente, en AI se obtuvo una inactivación completa de STEC no-O157 (ARG4827) a ambas temperaturas evaluadas. En base a nuestros resultados los bacteriofagos resultan promisorios para el biocontrol de cepas patógenas de E. coli, sin embargo, es necesario optimizar cada sistema fago\/cepa para prevenir, debido al recrecimiento observado en algunos casos, la potencial aparición de resistencia.","palabras_clave":"BACTERIOFAGOS|DECONTAMINACION|CARNICOS|ESCHERICHIA COLI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39845,"idioma_id":4,"titulo":"Guanacos in the Desert Puna: A trade-off between drinking and the risk of being predated","resumen":"Habitats vary not only in resource availability and quality but also in predation risk, among other factors.The Desert Puna of Argentina comprises two habitats: the shrub steppe and the vegas. The former, the most abundant habitat, is a topographically simple area with unavailable free water and poor food  quality; the latter is a very scarce and topographically complex habitat and with water available year round and high quality food. Guanaco relies heavily on vision to detect predators and narrow and complex habitats would be risky. Hence, we expected that guanacos would use the vegas in lowest proportion and would increase the time devoted to vigilance. Guanacos spent more time in the shrub-steppe than in the vegas, where the highest percentage of vigilant guanacos was recorded. A positive and signi&#64257;cant relationship between time devoted to foraging and number of animals per herd was observed in both habitats. In the shrub-steppe the opposite was observed for vigilance, whereas in the vegas, no relationship was observed. Despite the low availability of vegas and the high predation risk, they represent a critical habitat for guanacos in the Desert Puna, because they representing the only areas with free water available throughout year for wildlife.","palabras_clave":"FORAGING|LAMA GUANICOE|PREDATION RISK|VIGILANCE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39846,"idioma_id":4,"titulo":"Renal intraspecific variation along an aridity gradient detected by new  renal indices in a desert herbivorous rodent","resumen":"Mammals that live in arid and semi&#8208;arid environments in South America present physiologicalmechanisms that enable them to conserve water. Body water is lost through the kidneys, lungs, skin,and intestines. Regarding renal adaptation for water conservation, several indices have been usedto estimate the capacity of the kidneys to produce a maximum urine concentration. Most studieswere conducted at an inter&#8208;specific level, with only few performed at the intraspecific level. In thiswork, we compare renal function and morphology among five populations of Southern mountaincavy, Microcavia australis, present along an aridity gradient. We hypothesized that individuals fromdrier zones would present morphological and functional renal modifications that imply a greatercapability to conserve body water. These features were studied considering the classical indices(RMT, PMT, PMA, and RMA) and three new indices that consider area measurements; the lattershowed to be more adequate to reflect intraspecific differences. Our results suggest that themorphological modifications of kidneys, that is, the greater areas of renal inner medulla, would berelated to the aridity gradient where populations of Southern mountain cavy occur.","palabras_clave":"renal variation|aridity|Monte|rodent"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39847,"idioma_id":4,"titulo":"Jarosite versus Soluble Iron-Sulfate Formation and Their Role in Acid Mine Drainage Formation at the Pan de Azúcar Mine Tailings (Zn-Pb-Ag), NW Argentina","resumen":"Secondary jarosite and water-soluble iron-sulfate minerals control the composition of acid mine waters formed by the oxidation of sulfide in tailings impoundments at the (Zn-Pb-Ag) Pan de Azúcar mine located in the Pozuelos Lagoon Basin (semi-arid climate) in Northwest (NW) Argentina. In the primary zone of the tailings (9.5 wt % pyrite-marcasite) precipitation of anglesite (PbSO4), wupatkite ((Co,Mg,Ni)Al2(SO4)4) and gypsum retain Pb, Co and Ca, while mainly Fe2+, Zn2+, Al3+, Mg2+, As3+\/5+ and Cd2+ migrate downwards, forming a sulfate and metal-rich plume. In the oxidation zone, jarosite (MFe3(TO4)2(OH)6) is the main secondary Fe3+ phase; its most suitable composition is M = K+, Na+, and Pb2+and TO4 = SO42&#8722;; AsO42&#8722;. During the dry season, iron-sulfate salts precipitate by capillary transport on the tailings and at the foot of DC2 (tailings impoundment DC2) tailings dam where an acid, Fe2+ rich plume outcrops. The most abundant compounds in the acid mine drainage (AMD) are SO42&#8722;, Fe2+, Fe3+, Zn2+, Al3+, Mg2+, Cu2+, As3+\/5+, Cd2+. These show peak concentrations at the beginning of the wet season, when the soluble salts and jarosite dissolve. The formation of soluble sulfate salts during the dry season and dilution during the wet season conform an annual cycle of rapid metals and acidity transference from the tailings to the downstream environment.","palabras_clave":"sulfide oxidation|mine tailings|soluble iron-sulfate salts|jarosite"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39848,"idioma_id":4,"titulo":"Leuconostoc bacteriophages from blue cheese manufacture: long term survival, resistance to thermal treatments, high pressure homogenization and chemical biocides of industrial application","resumen":"Nine Leuconostoc mesenteroides phages were isolated during blue cheese manufacture yielding faulty products with reduced eye formation. Their morphologies, restriction profiles, host ranges and long-term survival rates (25ºC, 8ºC, -20ºC and -80ºC) were analyzed. Based on restriction analysis, six of them were further examined regarding resistance to physical (heat and high pressure homogenization, HPH) and chemical treatments (ethanol, sodium hypochlorite, peracetic acid, biocides A, C, E and F). According to their morphology, Ln. mesenteroides phages studied in the present work belonged to Caudovirales order and Siphoviridae family. Six distinct restriction patterns were obtained with EcoRV, HindIII, ClaI and XhoI enzymes, revealing interesting phage diversity in the dairy environment. No significant reductions in phage counts were observed after ten months of storage at -20ºC and -80ºC, while slightly and moderate decrease in phage numbers were noticed at 8ºC and 25ºC, respectively. Phages subjected to heat treatments generally showed high resistance at 63ºC and moderate resistance at 72ºC. However, 80ºC for 30 min and 90ºC for 2 min led to complete inactivation of viral particles. In general, the best ethanol concentration tested was 75%, as complete inactivation for most Leuconostoc phages within 30 min of incubation was achieved. Peracetic acid, biocides A, C, E and F were highly effective when used at the same or at a moderately lower concentration as recommended by the producer. Usually, moderate or high concentrations (600-1600 ppm) of sodium hypochlorite were necessary to completely inactivate phage particles. Leuconostoc phages were partially inactivated by HPH treatments as remaining viral particles were found even after 8 passes at 100 MPa. This is the first report of Ln. mesenteroides phages isolated from an Argentinean dairy cheese plant. Results of this work could be useful for establishing the most effective physical and chemical treatments for inactivating phages in industrial plants and laboratory environments","palabras_clave":"LEUCONOSTOC|BACTERIOPHAGES|INACTIVATION|INDUSTRIAL TECHNOLOGIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39849,"idioma_id":4,"titulo":"Technological and probiotic characterization of Lactobacillus casei \/ paracasei strains and their phage resistant mutants","resumen":"Technological, biological and functional attributes of two groups of spontaneousbacteriophage-resistant mutants were investigated to verify similar features to those of theirrespective parental phage-sensitive probiotic strains (Lactobacillus casei\/paracasei). A derivative from each group was challenged with phages in simulated probiotic product fermentation. Proper technological performance, contrastingly with the original strains, was demonstrated. Minimalvariations were detected in acidifying and enzymatic profiles. No &#946;-glucuronidase but very high &#945;-glucosidase and &#946;-galactosidase activities were recorded. Poor proteolytic activities and inability to ferment prebiotics were observed. Within one group, significant difference throughout simulatedgastrointestinal-transit was observed. Neither of the strains deconjugated bile salts, but all showedinhibitory activity against four pathogens. Both mutants increased IgA producing cells´ number in vivo similarly to their parental strains did. Two derivatives demonstrated improved phage-resistance phenotype compared to the parental strains, thus resulting in alternatives for industrial rotation schemes. For probiotic strains, this strategy deserves special mention","palabras_clave":"LACTOBACILLUS CASEI\/PARACASEI|BACTERIOPHAGES|INSENSITIVE MUTANTS|DAIRY INDUSTRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39850,"idioma_id":5,"titulo":"Surcadores Monodisco y bidisco: Análisis comparativo","resumen":"Ante las controversias generadas por la falta de información acerca del desempeño de los distintos órganos utilizados para la apertura del surco en siembra directa, en el Laboratorio de Terramecánica e Implantación de Cultivos del Instituto de Ingeniería Rural (INTA Castelar) se comenzaron a evaluar algunos de los principales implementos utilizados en los trenes de siembra en las áreas productivas más representativas de la Argentina. El objetivo de este trabajo fue realizar una evaluación comparativa de la eficiencia de implantación de dos surcadores de disco de gran adopción por los diseñadores de maquinaria agrícola. En cuanto a la profundidad de siembra elegida de 40 mm, los valores alcanzados fueron de 39,9 y 32,2 mm por el monodisco y el bidisco respectivamente. Se observó la influencia que genera la presencia de rastrojo sobre la eficiencia de implantación del cultivo de trigo y el desempeño de las cuchillas labrasurco. ","palabras_clave":"SIEMBRA DIRECTA|EFICIENCIA DE IMPLANTACIÓN|SEMBRADORAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39852,"idioma_id":4,"titulo":"Inter-Domain Interactions in Charged Lipid Monolayers","resumen":"Phase coexistence is common in model bio-membranes with the presence of domains formed by lipids in a dense phase state modulating lateral diffusion of species through hydrodynamic and electrostatic interactions. In this study, inter-domain interactions in monolayers of charged surfactants were analyzed and compared with neutral systems. Interactions were investigated at different inter-domain distances and by varying the ionic strength (I) of the subphase. At low percentages of condensed area (%Ac), i.e. high inter-domain distances, domains were approximated as point charges or dipoles, and a comparison between the simulated and experimental results was made. At high %Ac, domains were arranged in a distorted hexagonal lattice, and the energy of a domain around its equilibrium position in the lattice was modeled using a harmonic potential and the spring constant determined.  On subphases of high I, charged domains interacted in a manner similar to neutral domains with domain motion being precluded at high percentages of condensed area. At low I, a higher inter-domain repulsion was observed along with a lower domain motion and, therefore, a higher apparent viscosity at comparable %Ac. Interestingly, this effect was observed at conditions where the Debye-Hückel length was still two orders lower than the inter-domain distances.","palabras_clave":"Monolayers|Electric Field|Molecular Dynamics Simulation|Lipid Difussion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39853,"idioma_id":4,"titulo":"A new model for the prediction of oxygen interference in hydrogen storage systems","resumen":"A new model is developed to analyze oxygen interference in hydrogen   storage materials. It is based on the competitive adsorption isotherm   between the two gases, with the parameters fitted from molecular dynamic   simulations. The model is applied to a system consisting of graphene   sheets separated by different distances. For a gas-phase mixture of   hydrogen (99.9%) and oxygen (0.1%) in interaction with porous graphite   of 6.5 Å (optimum size) it can be observed that after 50 cycles of   charging\/discharging the blocking of active sites of the material by   oxygen is &#8764;10%, due to progressive pollution of the system by oxygen.   The model presented here may easily be extended to other systems of   interest, involving other blocking species or adsorbent materials.","palabras_clave":"hydrogen storage|carbon materials"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39854,"idioma_id":4,"titulo":"A New Approach for the Calculation on the Entropic and Free Energy Contributions to Underpotential Deposition","resumen":"In the present work we have studied the electrochemical nonpseudomorphic formation of Pbbidimensional structures on Au(111) surfaces. Based on the two-phase thermodynamic method, we haveanalyzed, from a computational perspective, entropic and energetic contributions to underpotentialdeposition. The occurrence of incommensurate nanophase formation, rotation of the adsorbate withrespect to the substrate, and the effect of expansion and compression of the Pb monolayer were alsoanalyzed. Our results show that the entropic contribution to monolayer underpotential deposition of Pb onAu(111) at room temperature is approximately 20% of the total free energy excess. For very smallclusters, this contribution increases up to 45%. Simulations show that in the early stages of formation, Pbnanophases grow without rotation. When the size of the Pb islands is close 100 atoms, a rotation processtakes places. At relatively high coverage, a strong lateral compression of Pb monolayer sets on, evidencedby a sharp decrease in the distance between nearest neighbors.","palabras_clave":"underpotential deposition|entropy|computer simuilation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39855,"idioma_id":4,"titulo":"Hydroxytyrosol and Oleuropein of olive oil Inhibit Mast Cell Degranulation Induced by Immune and Non-Immune Pathways","resumen":"The aim of this study was to determine whether hydroxytyrosol and oleuropein, the major phenols found in olives and olive oil, inhibit mast cell activation induced by immune and non-immune pathways. Purified peritoneal mast cells were preincubated in the presence of test compounds (hydroxytyrosol or oleuropein), before incubation with concanavalin A, compound 48\/80 or calcium ionophore A23187. Dose-response and time-dependence studies were carried out. Comparative studies with sodium cromoglycate, a classical mast cell stabilizer, were also made. After incubation the supernatants and pellets were used to determine the beta-hexosaminidase content by colorimetric reaction. The percentage of beta-hexosaminidase release in each tube was calculated and taken as a measure of mast cell activation. Other samples of cell pellets were used for cell viability studies by the trypan blue dye exclusion test, or fixed for light and electron microscopy. Biochemical and morphological findings of the present study showed for the first time that hydroxytyrosol and oleuropein inhibit mast cell degranulation induced by both immune and non-immune pathways. These results suggest that olive phenols, particularly hydroxytyrosol and oleuropein, may provide insights into the development of useful tools for the prevention and treatment of mast cell-mediated disorders.","palabras_clave":"Degranulation|Hydroxytyrosol|Mast cell|Olea europaea|Oleuropein|&#946;-Hexosaminidase"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39856,"idioma_id":5,"titulo":"Conocimiento científico, desastres, y política pública. Dossier","resumen":"Se trata de la compliacion de un dossier espeial de la revista. Incluye un estudio previo donde se propone una conceptualizacion de los desastres como objeto de analisis del campo  ciencia, tecnología y sociedad (CTS) y se realiza la presentación comparativa de los trabajos compilados para el dossier. El propósito ha sido  acercar a los lectores de CTS un campo de  investigación y reflexión incipiente en la región iberoamericana, así como también  contribuir a su desarrollo y difusión. Los artículos incluidos en esta compilación han  sido preparados por autores iberoamericanos que, aplicando un enfoque basado en  el análisis CTS, abordan  algunas de las muy diversas dimensiones en que se expresa la relación entre  desastres y conocimiento científico y tecnológico.","palabras_clave":"desastres|conocimiento científico |riesgo|politicas publicas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39857,"idioma_id":4,"titulo":"Unveiling the mechanism of core-shell formation by counting the relative occurrence of microstates","resumen":"A procedure usually applied to construct free energy surfaces for a system at equilibrium is found here useful for obtain information on a non-equilibrium process. The joint probability of observing collective variables from a swarm of irreversible molecular dynamic trajectories is analyzed. This straightforward procedure can supply detailed mechanistic information on the irreversible coalescence of two particles made of 42 Au atoms and 13 Co atoms respectively. A complex mechanistic behavior is unveiled using the analysis proposed. This is performed without the need to compute large databases containing minima and transition rates, as required by master equation methods.","palabras_clave":"MICROSTATE OCURRENCE|NON-EQUILIBRIUM|COALESCENCE|NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39858,"idioma_id":4,"titulo":"Synthesis and cytotoxic evaluation of four new 6E-hydroximinosteroids","resumen":"Four new 6E-hydroximinosteroids (1, 2a, 3 and 4) have been synthesized from the corresponding ketones, 2b,3b-dihydroxy-5a-cholestan-6-one (5), 2a,3a-dihydroxy-5a-cholestan-6-one (6), 2b,3adihydroxy-5a-cholestan-6-one (7) and 2b,3a-dihydroxy-5a-cholestan-6-one-disulfate (8). The cytotoxic activity of the steroidal oximes was evaluated against two prostate carcinoma cell lines (PC-3 and LNCaP) and compared with that of five polyhydroxylated sulfated analogs (8?12). Oxime 3 and trisulfated analog 11 were the most active compounds with IC50 values of 10.8 lM (PC-3) and 7.9 lM (LNCaP), respectively.","palabras_clave":"HYDROXIMINOSTEROIDS|SYNTHESIS|SULFATED STEROIDS|PROSTATE CANCER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39859,"idioma_id":4,"titulo":"Characterization of N-homocysteinylated albumin adducts","resumen":"        Increased plasma homocysteine (Hcy) levels are  considered an important risk factor for vascular disease. Hcy, an intermediate  compound in methionine metabolism, is an amino acid that includes a thiol  group, and circulates as different species. One of them,  homocysteine-thiolactone (HTL) forms adducts through irreversible reactions  with epsilon-NH2 groups of lysine residues. These processes can  alter the structure and biological function of diverse proteins that may be  involved in the detrimental effects of Hcy. Particularly, in this work we  evaluated HTL-mediated molecular changes in human serum albumin (HSA) through  electrophoretic techniques. Albumin and HTL were incubated (37ºC, 6 h) at HSA:HTL molar  ratios of 1:25, 1:50 and 1:100. Polyacrilamide gel electrophoresis (PAGE)  showed that electrophoretic mobility was increased in the treated HSA respect  to control, in an HTL-concentration-dependent manner. That anodic shift of the  treated samples was also observed in crossed  immunoelectrophoresis (CIE) profiles. As expected, a decrease in the  isoelectric point of the homocysteinilated albumin (pI 4.7) in comparison to  that of control (pI 4.8) was shown by the isoelectric focusing technique (IEF).  Moreover, the electropherogram acquired by capillary zone electrophoresis (CZE)  indicated that migration times and full width at half height were enhanced with  the rise of HTL concentration. We propose that the in vitro structural  changes of albumin described in the present work would be involved in  the harmful effects of the N-homocysteinylation process.  ","palabras_clave":"ALBUMIN|CAPILLARY ZONE ELECTRPPHORESIS|CROSSED IMMUNOELECTROPHORESIS|HOMOCYSTEINE-THIOLACTONE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39860,"idioma_id":4,"titulo":"?\tImpact of homocysteine-thiolactone on plasma fibrin networks","resumen":"Epidemiologic studies have shown that hyperhomocysteinemia is an independent risk factor for vascular disease. Homocysteine (Hcy) circulates as different species, mostly protein bound, and approximately 1% as its reduced form and the cyclic thioester homocysteine-thiolactone (HTL). Despite the level of plasma thiolactone being markedly low, detrimental effects are related to its high reactivity. HTL reacts with proteins by acylation of free basic amino groups; in particular, the epsilon-amino group of lysine residues forms adducts and induces structural and functional changes in plasma proteins. In order to assess the effects of HTL on plasma fibrin networks, a pool of normal plasma incubated with HTL (100, 500 and 1,000 &#956;mol\/L, respectively) was evaluated by global coagulation tests and fibrin formation kinetic assays, and the resulting fibrin was observed by scanning electron microscopy. HTL significantly prolonged global coagulation tests in a concentration-dependent manner with respect to control, and increases were up to 14.5%. Fibrin formation kinetic parameters displayed statistically significant differences between HTL-treated plasma and control in a concentration-dependent way, showing higher lag phase and lower maximum reaction velocity and final network optical density. Electron microscopy analysis of HTL plasma networks revealed a compact architecture, with more branches and shorter fibers than control. We can conclude that HTL induced a slower coagulation process, rendering more tightly packed fibrin clots. Since these features of the networks have been related to impaired fibrinolysis, the N-homocysteinylation reactions would be involved in the prothrombotic effects associated to hyperhomocysteinemia.","palabras_clave":"HOMOCYSTEINE-THIOLACTONE|FIBRIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39861,"idioma_id":4,"titulo":"Naturally occurring compounds elicit HIV-1 replication in chronically infected promonocytic cells","resumen":"Since antiretroviral therapy suppresses but does not eradicate HIV-1 infection,methods to purge viral reservoirs are required. Many strategies involve the reactivation of chronically HIV infected cells to induce the expression of integrated viral genome. In this study, five bioactive compounds, the plant derivatives 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), nordihydroguaiaretic acid (NDGA), and curcumin (Cur) and the synthetic stigmasterol analogs (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (compound 1) and (22S,23S)-3b-bromo-5a,22,23-trihydroxystigmastan-6-one (compound 2), were evaluated for their ability to elicit HIVreplication in promonocytic (U1) and lymphocytic (H9+) HIV-1 chronically infected cells. The results revealed that natural compounds CDM, NDGA, and Cur were able to increase HIV-1 p24 antigen, determined by ELISA, only in latently infected promonocytic cells. CDM would reactivate HIV from latency by modulating the release of IL-6 and TNF-a, since the amount of both cytokines measured through ELISA significantly increased in U1 treated cells. Besides, NDGA increased ROS production, which might be related to the increase on p24 level observed in NDGA treated U1. These findings suggest that CDM, NDGA, and Cur might be candidates for further studies on latency-reversing therapeutics to eliminate latently HIV-1 reservoirs.","palabras_clave":"HIV|CHRONIC INFECTION|NATURAL COMPOUNDS|PROMONOCYTIC CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39862,"idioma_id":4,"titulo":"Autosomal dominant cerebellar ataxias: a systematic review of clinical features","resumen":"BACKGROUND AND PURPOSE:  To assess, through systematic review, distinctive or common clinical signs of autosomal dominant cerebellar ataxias (ADCAs), also referred to as spinocerebellar ataxias (SCAs) in genetic nomenclature.  METHODS:  This was a structured search of electronic databases up to September 2012 conducted by two independent reviewers. Publications containing proportions or descriptions of ADCA clinical features written in several languages were selected. Gray literature was included and a back-search was conducted of retrieved publication reference lists. Initial selection was based on title and abstract screening, followed by full-text reading of potentially relevant publications. Clinical findings and demographic data from genetically confirmed patients were extracted. Data were analyzed using the chi-squared test and controlled for alpha-error inflation by applying the Holms step-down procedure.  RESULTS:  In all, 1062 publications reviewing 12 141 patients (52% male) from 30 SCAs were analyzed. Mean age at onset was 35 ± 11 years. Onset symptoms in 3945 patients revealed gait ataxia as the most frequent sign (68%), whereas overall non-ataxia symptom frequency was 50%. Some ADCAs often presented non-ataxia symptoms at onset, such as SCA7 (visual impairment), SCA14 (myoclonus) and SCA17 (parkinsonism). Therefore a categorization into two groups was established: pure ataxia and mainly non-ataxia forms. During overall disease course, dysarthria (90%) and saccadic eye movement alterations (69%) were the most prevalent non-ataxia findings. Some ADCAs were clinically restricted to cerebellar dysfunction, whilst others presented additional features.  CONCLUSIONS:  Autosomal dominant cerebellar ataxias encompass a broad spectrum of clinical features with high prevalence of non-ataxia symptoms. Certain features distinguish different genetic subtypes. A new algorithm for ADCA classification at disease onset is proposed.","palabras_clave":"ataxia and gait disorders|movement disorders|spinocerebellar ataxia|systematic review"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39863,"idioma_id":4,"titulo":"One-step \/ one-pot decoration of oxide microparticles with silver nanoparticles","resumen":"Hypothesis: Heterogeneous nucleation of silver oxide (Ag2O) onto oxide microparticles (OMPs) followed by spontaneous thermal decomposition produce nanostructures made of OMPs decorated with silver nanoparticles (OMP|AgNPs).Experiments: Colloidal chemistry methods have been used to produce the decoration of OMPs with silver nanoparticles (AgNPs), by carrying out the Ag2O precipitation\/thermal decomposition. The process is dri-ven in water enriched acetone medium containing NaOH, NH3, AgNO3 and SiO2MPs as substrate. Optical and morphological properties of OMP|AgNPs were characterized by using STEM, EDS, HRTEM and Raman spectroscopy.Findings: A new synthetic method to decorate OMPs (TiO2, SiO2) with metallic AgNPs in a single step\/single pot reaction is proven effective to produce OMP|AgNPs either in aqueous or water enriched media.","palabras_clave":"Silver|oxide Decomposition|decoratios|oxide microparticles"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39864,"idioma_id":6,"titulo":"L'attraction du capital étranger dans le secteur des mines argentin et l essor des assemblées socio-environnementales","resumen":"À partir des années 1990 l´État argentin met en place une série de réformes qui fondent un nouveau cadre juridique minier et créent des conditions très favorables pour les capitaux qui investissaient dans ce secteur. À la fin de cette même décennie a lieu le 'boom minier', un processus qui a pour conséquence une augmentation considérable des projets miniers métallifères qui se développent dans tout le pays, mais aussi des Investissements directs étrangers (IDE) et de la production du secteur. Tout indique que cette croissance de l´activité minière-métallifère est rendue possible par le développement de nouvelles technologies qui permettent l´extraction de minéraux impossible à extraire avec les méthodes traditionnelles ; elle est en même temps favorisée par l´augmentation du prix des métaux sur le marché mondial.    Malgré cela, cet essor qu´avait eu l´activité minière entre 1996 et 1997 s´interrompt suite à la crise asiatique, qui provoque l´interruption momentanée de certains projets miniers mais surtout incite les entrepreneurs à être plus prudents lorsqu´ils investissent dans de nouveaux projets. Cette période au cours de laquelle une certaine instabilité prédomine dans le secteur des mines, semble toutefois se terminer en 2002, quand le prix des métaux remonte à nouveau. Au début du XXIe siècle, le secteur minier commence à se récupérer y compris des répercussions de la récession de 2001, quand il subit un nouveau coup. Cette fois non pas à cause d´une crise internationale, mais des mobilisations sociales contre la mise en place de projets miniers, qui ont pour conséquence la fin de la stabilité politique et juridique sur laquelle le secteur minier avait compté jusque-là.    Au vu de tout cela, il y a de nombreuses raisons de considérer que l´analyse de la question minière argentine est cruciale. D´abord parce que c´est une des activités du pays qui a connu le plus de croissance au cours des deux dernières décennies. Ensuite parce que même si l´on ne parlera que de l´Argentine, de nombreuses caractéristiques de ce cas sont inévitablement semblables à celles d´autres pays latino-américains. De plus, parce qu´elle s´insère dans les débats sur les activités dites 'extractives' et leur relation avec l´expansion continuelle du capital. En lien avec cela et dans le cadre des nouvelles théories sur impérialisme et mondialisation, qui reformulent de vieux débats, certains auteurs revisitent le concept     'd´accumulation primitive' utilisé par Marx (2008) et baptisent  'accumulation par dépossession' (Harvey, 2004; De Angelis, 2001; Bonefeld, 2001) la nouvelle phase d´expansion du capital inaugurée après la crise de suraccumulation des années 1970, à cause de la réactualisation et de l´approfondissement des mécanismes de prédation. De même, du point de vue des investissements, des auteurs comme Holloway (1992) ou Hirsch (1992, 1996), expliquent que les États sont en concurrence entre eux pour attirer une portion du capital global. Enfin, parallèlement à l´augmentation du nombre des mines, des protestations se sont également développées dans tout le pays, remettant en cause les mégaprojets miniers, allant jusqu´à contester que l´activité minière apporterait une meilleure qualité de vie aux populations des provinces argentines. On a ainsi vu naître, à partir de 2002, des 'assemblées pour le NON à la mine', produits du mouvement de 2001 en Argentine mais dotées de leurs propres pratiques et d´un point de vue nouveau sur la relation capital-nature et capital-travail, à l´origine d´intéressants débats en Argentine et dans plusieurs pays latino-américains.            Les nouveaux acteurs des luttes socio-environnementales ont incontestablement réussi à insérer dans l´agenda de l´opinion publique des thématiques dont l´importance était jusqu´ici ignorée, même par la plupart des secteurs de la gauche. La suite de cet article se compose de deux parties. Dans la première, nous analyserons les principales caractéristiques du processus que l´on appelle 'boom minier' ; dans la seconde, nous parlerons des résistances sociales contre l´avancée des projets méga-miniers, dans tout le territoire argentin.","palabras_clave":"Minería|Inversiones|Asambleas|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39865,"idioma_id":4,"titulo":"Extensive pollen flow in a natural fragmented population of Patagonian cypress Austrocedrus chilensis","resumen":"Habitat fragmentation might significantly affect mating and pollen dispersal patterns in plant populations, contributing to the decline of remnant populations. However, wind-pollinated species are able to disperse pollen at longer distances after opening of the canopy. Our objectives were to characterize the mating system parameters and to estimate the average distance of effective pollen dispersal in the wind-pollinated conifer Austrocedrus chilensis. We sampled 19 'mother trees', 200 progeny, and 81 additional adults (both male and female), in a fragmented population at the Argentinean Patagonian steppe. We registered the spatial positions of individuals and genotyped all samples with five microsatellite markers. We found a high genetic diversity, a moderated rate of biparental inbreeding (tm-ts=0.105), and a complete absence of correlated paternity (rp=-0.015). The effective number of pollen donors contributing to a single mother (Nep) was 13.9. Applying TWOGENER, we estimated a low but significant differentiation among the inferred pollen pools (PhiFT=0.036, p=0.001) and a very large average pollen dispersal distance (d=1032.3m). The leptokurtic distribution (b=0.18) presumes a potential for even larger dispersal distances. The high genetic diversity, the mating patterns, and the extensive pollen dispersal presume that habitat fragmentation did not have a negative impact on pollen movement in this population of A. chilensis. Genetic connectivity among fragmented populations scattered in the Patagonian region is possible, and we stress the need of management policies at the landscape level.","palabras_clave":"Gene flow|TWOGENER|Mating system|Pollen dispersal|Patagonian cypress"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39866,"idioma_id":4,"titulo":"Phytotherapy of Polish migrants in Misiones, Argentina: Legacy and acquired plant species","resumen":"Ethnopharmacological relevance: Analyzing  how and why phytotherapeutical practices survive in a migratory process is  important for understanding migrants? health seeking behavior and health  demand. Contrary to most studies, which focus on migrants form warm climates who  settle in European and American cities, this study explores the continuations  in herbal pharmacopoeia of Eastern European peasants who settled down in rural  subtropical areas of Argentina. The study also explores the pharmacopoeia among  the descendents from the first generation born in Argentina.     Material  and methods: In this study  primary and secondary sources were employed. Data were collected during over  200 interviews (semi-structured, free lists, in-depth) directed to 94 study  participants. Voucher specimens of mentioned species were gathered and  identified. Illnesses were reported according to local ethnomedical terminology  and classification. Only the reports of self-experience were included in the  analysis. The unit of analysis was a plant use report (plant species x plant part  x ailment x informant). The frequency of mentions was calculated for plant  part used and mode of preparation and administration of herbal medicines, also  the Informant Diversity Value was estimated. The secondary information was  obtained from ethnobotanical and ethnomedical literature concerning whole  Poland. A list of medicinal plant species known form Poland available in the  study area was made. Then, the similarity between the available species and the  used ones by Polish migrants was evaluated by applying Simpson index.     Results: An  exhaustive list of 129 plant species used by Polish community in Misiones,  Argentina, was obtained. Among 37 available species in Misiones, known form  Poland, 19 are used by this community. There has been low consensus in the  health conditions treatment with legacy plants between Polish migrants and the  Polish folk pharmacopoeia. The reasons for relative low use of heritage species  are explained. More continuation has been observed in forms of application and  administration of medicinal plants. Most of the continued species are food  plants and have been predominantly applied as medicinal food.    Conclusions: In  the migratory process Polish peasants have preserved culturally salient species  with a wide range of therapeutic applications and easily accessible. Polish migrants, and their  descendents, have incorporated a great number of local medicinal plant species  into their home medicine but at the same time retained traditional ways of  herbal medicines administration. Based on the theory of acculturation, the  observed pattern of medicinal plant use in Polish migrant colonies in Misiones indicates  well adaptation to predominant cultural environment.    &nbsp;","palabras_clave":"Heritage plant species|Medicinal plants|Informant Diversity Value|Pharmacopeia validation|Optimal adaptation|Ways of preparation and administrarion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39867,"idioma_id":4,"titulo":"Identification of Giardia lamblia DHHC proteins and the role of protein S-palmitoylation in the encystation process","resumen":"  Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a  common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In  this work, we analyzed the presence of DHHC proteins in the protozoa parasite Giardia lamblia and the function of the  reversible S-palmitoylation of proteins during parasite differentiation into cyst. Two specific events were observed:  encysting cells displayed a larger amount of palmitoylated proteins, and parasites treated with palmitoylation inhibitors  produced a reduced number of mature cysts. With bioinformatics tools, we found nine DHHC proteins, potential protein  acyltransferases, in the Giardia proteome. These proteins displayed a conserved structure when compared to different  organisms and are distributed in different monophyletic clades. Although all Giardia DHHC proteins were found to be  present in trophozoites and encysting cells, these proteins showed a different intracellular localization in trophozoites and  seemed to be differently involved in the encystation process when they were overexpressed. dhhc transgenic parasites  showed a different pattern of cyst wall protein expression and yielded different amounts of mature cysts when they were  induced to encyst. Our findings disclosed some important issues regarding the role of DHHC proteins and palmitoylation  during Giardia encystation.","palabras_clave":"PALMITOYLATION|PARASITES|GIARDIA LAMBLIA|ENCYSTATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39868,"idioma_id":5,"titulo":"GASIFICACIÓN ISOTÉRMICA CON OCTAVE","resumen":"La gasificación es un proceso de termoconversión donde la biomasa sólida (pellets de aserrín) se convierte en gas, a través de oxidación parcial a temperaturas altas. El modelo utilizado se basa en la teoría de las dos fases (burbuja ? emulsión), adecuado para predecir resultados experimentales en reacciones que ocurren en lechos fluidizados.  El modelo se simula a partir del conjunto de ecuaciones diferenciales ordinarias para los balances de masa y de energía; como así también, estudios hidrodinámicos de porosidad, velocidad, fracción de burbujas, con determinadas suposiciones como el comportamiento isotérmico del proceso.","palabras_clave":"GASIFICACION|MODELO|SIMULACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39869,"idioma_id":4,"titulo":"Current Status of Allograft Tolerance in Intestinal Transplantation","resumen":"Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolerance has been the ?holy grail? for transplantation medicine since its beginnings. Different experimental approaches and clinical trials resulted in the accumulation of knowledge on mechanisms and strategies that favor the establishment of tolerance without achieving the objective of autonomous allograft tolerance in the clinical field. Development of tolerance in intestinal transplantation constitutes a challenging situation due to several particular features that contribute to the generation of a strong allogeneic response. In the present review, we summarize the different immune mechanisms that may contribute to allograft tolerance. The different barriers that should be bypassed in intestinal transplantation to tolerate the graft are discussed. Finally, we revise the strategies that were applied with different degrees of success in the clinical field including the most promising recent approaches and the forthcoming candidates in the field that might be translated into clinical trials in the near future.","palabras_clave":"adoptive cellular therapy|chimerism|operational tolerance|rejection|small bowel"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39870,"idioma_id":4,"titulo":"Critical Water Effect on the Plasmon Band and Visible Light Activity of Au\/ZnO Nanocomposites","resumen":"Small amounts of water (between and 0.05 and 0.35% V\/V)  critically determine the morphology and plasmon band of Au\/ZnO  nanostructures obtained by Au3+ photoreduction on ZnO nanoparticles  dispersed in 2-propanol. All the synthesized materials exhibit plasmon induced activity to drive the solvent oxidation; however, the temporal evolution of acetone shows a clear induction time followed by the sudden boost in the rate of the oxidation product, which depends on the photodeposition conditions. Xray photoelectron spectroscopy (XPS) indicates that visible irradiation produces the transformation of surface Au(0) in Au(+). Besides, an increment in the ZnO surface area ascribed to the photoinduced fragmentation of aggregated networks of Au\/ZnO nanocomposites is evidenced by XPS and simple adsorption experiments. The changes in the surface properties correlate with the onset in the catalytic activity. Possible mechanisms are discussed to account for the experimental findings.","palabras_clave":"plasmon|nanocomposites|critical effect"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39871,"idioma_id":5,"titulo":"Morbilidad severa materna y neonatal: vigilancia en servicios y capacidad de respuesta del sistema de salud","resumen":"Introducción: En el mundo, 358.000 mujeres mueren cada año por complicaciones del embarazo, parto o puerperio, junto a más de 4.000.000 de muertes neonatales, 75% dentro de la primera semana de vida. Las complicaciones maternas agudas graves (cuadros clínicos críticos durante el aborto, el embarazo, el parto o el postparto que evolucionan favorablemente hacia la sobrevida), comparten características con las muertes maternas y son una fuente de información directa sobre los obstáculos a superar después de su aparición. Pueden complementar la información que se obtiene al revisar las muertes maternas y actuar como sustitutos de las mismas.Métodos: Estudio de corte transversal. Se relevó la prevalencia y el manejo de las complicaciones maternas graves asociadas con la mortalidad materna y neonatal en maternidades públicas de las provincias de Corrientes y Santa Fe durante 3 meses. Se evaluaron la disponibilidad y uso de intervenciones preventivas y terapéuticas. Resultados: Entre septiembre y diciembre de 2012,  fueron incluidas 6.121 mujeres atendidas en 3 maternidades públicas de Corrientes y en 10 de Santa Fe. Se detectaron condiciones potencialmente fatales en 755 casos (12,3%) y complicaciones agudas graves en 28 casos (0,5%).  El sulfato de magnesio se utilizó en el 100 % de los casos de eclampsia, siendo elevado también el uso de uterotónicos para la prevención de la hemorragia posparto. La cobertura con antibióticos y corticoides antenatales fue menor. Los indicadores de morbilidad severa sugieren que hasta en dos tercios de los casos las complicaciones se inician antes de la llegada al hospital, o durante las primeras 24 horas.Discusión: el monitoreo de las complicaciones maternas agudas graves permite conocer, entre otros, las incidencias locales y los patrones de mortalidad y morbilidad severa materna, las fortalezas y debilidades en los sistemas de referencia y la correcta utilización (o no utilización) de intervenciones clínicas y de sistemas de salud.","palabras_clave":"Mortalidad Materna|Morbilidad Materna|Vigilancia Epidemiológica|Incidencia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39872,"idioma_id":5,"titulo":"MEJORA EN IMÁGENES ACÚSTICAS UTILIZANDO RANGO DINAMICO ALTO (RDA)","resumen":"Las imágenes acústicas se obtienen mediante algoritmos de pos proceso. Estos utilizan los datos adquiridos a través de una distribución de sensores de presión o arreglo de micrófonos. Este arreglo, limita el rango dinámico de la imagen acústica. Por lo tanto, si existen fuentes de ruido con diferencia de nivel de presión sonora mayor al rango dinámico del arreglo no se podrán distinguir ya que los lóbulos laterales de la fuente principal cubrirán las fuentes sonoras menores. Esto puede solucionarse aumentando el número de micrófonos y así aumentar el rango dinámico pero se incrementaría el costo del hardware. Otra forma de solucionar este problema es mediante el pos proceso adecuado de los datos. Por lo tanto, debido al aumento en la capacidad de cálculo computacional es conveniente utilizar algoritmos que logren este cometido como lo es el Rango Dinámico Alto (RDA). La idea básica del método es extraer del mapa de ruido la máxima fuente sonora incluyendo sus lóbulos laterales y colocarlo en un mapa ?limpio?, luego con las señales sin la fuente principal se vuelve a reconstruir el mapa de ruido y nuevamente se extrae la segunda fuente dominante con sus lóbulos laterales. De esta manera se puede aplicar sucesivamente el método hasta extraer la cantidad de fuentes seleccionadas. Esto permite obtener un mapa de ruido con baja influencia de fuentes fantasmas y aumentar el rango dinámico de la imagen acústica.En este trabajo se presenta un sistema de formación de imágenes acústicas optimizado. En primer lugar se optimizó una distribución de micrófonos para mejorar el rango dinámico de la imagen acústica. Y en segundo lugar, se presenta el algoritmo Rango Dinámico Alto (RDA) que permite aumentar más aún la escala de medición de la imagen acústica basado en la técnicas de retardo y suma convencional en el dominio del tiempo.","palabras_clave":"imágenes acústicas|retardo y suma|rango dinámico alto|Fuente de ruido"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39873,"idioma_id":5,"titulo":"Sistemas de referencia en la enseñanza de la Astronomía. Un análisis a partir de una revisión bibliográfica","resumen":"      Se presenta  el resultado de un proceso de revisión bibliográfica centrado en identificar cuáles  son los sistemas de referencia astronómicos que utilizan los investigadores,  tanto implícita como explícitamente, cuando intentan averiguar y categorizar  las concepciones de los alumnos y docentes en relación a la comprensión de los  fenómenos astronómicos más cotidianos (día y noche, estaciones del año y fases de  la Luna) y  cuando proponen secuencias de enseñanza acerca de dichos fenómenos. Las  conclusiones obtenidas muestran un predominio de artículos en los cuales los  fenómenos celestes son desarrollados desde un sistema de referencia externo a la Tierra, sin hacer mención a  la posibilidad de describirlos y explicarlos adecuadamente desde un sistema  posicionado en la superficie terrestre. Esto pone de manifiesto la necesidad de  explicitar y justificar con claridad el sistema de referencia que será  utilizado al llevar adelante investigaciones en esta temática.  ","palabras_clave":"Revisión bibliográfica|Investigaciones|Sistemas de referencia|Astronomía"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39874,"idioma_id":5,"titulo":"Analogías en la enseñanza de la estequiometría: revisión de páginas web","resumen":"      En este trabajo se  presentan los resultados de una búsqueda sobre analogías para enseñar  estequiometría, realizada en páginas web. Se analizan los resultados obtenidos  a la luz de una serie de preguntas que plantea la investigación y se emiten  sugerencias para la enseñanza. Se revisan las confusiones o concepciones  alternativas que pueden promover y la utilización que se hace de las imágenes.  Se concluye que un profesor encontrará en Internet muchos ejemplos de analogías,  pero pocas secuencias adecuadas y escasas propuestas sistematizadas y  fundamentadas a la luz del conocimiento de la Didáctica de las Ciencias. El  trabajo con la analogía debería reforzar especialmente la comprensión profunda  del significado de la ecuación química.  ","palabras_clave":"Enseñanza|Estequiometría|Analogías|Búsqueda en Internet"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39875,"idioma_id":4,"titulo":"How often do they have sex? A comparative analysis of the population structure of seven eukaryotic microbial pathogens","resumen":"The model of predominant clonal evolution (PCE) proposed for micropathogens does not state that genetic exchange is totally absent, but rather, that it is too rare to break the prevalent PCE pattern. However, the actual impact of this ?residual? genetic exchange should be evaluated. Multilocus Sequence Typing (MLST) is an excellent tool to explore the problem. Here, we compared online available MLST datasets for seven eukaryotic microbial pathogens: Trypanosoma cruzi, the Fusarium solani complex, Aspergillus fumigatus, Blastocystis subtype 3, the Leishmania donovani complex, Candida albicans and Candida glabrata. We first analyzed phylogenetic relationships among genotypes within each dataset. Then, we examined different measures of branch support and incongruence among loci as signs of genetic structure and levels of past recombination. The analyses allow us to identify three types of genetic structure. The first was characterized by trees with well-supported branches and low levels of incongruence suggesting well-structured populations and PCE. This was the case for the T. cruzi and F. solani datasets. The second genetic structure, represented by Blastocystis spp., A. fumigatus and the L. donovani complex datasets, showed trees with weakly-supported branches but low levels of incongruence among loci, whereby genetic structuration was not clearly defined by MLST. Finally, trees showing weakly-supported branches and high levels of incongruence among loci were observed for Candida species, suggesting that genetic exchange has a higher evolutionary impact in these mainly clonal yeast species. Furthermore, simulations showed that MLST may fail to show right clustering in population datasets even in the absence of genetic exchange. In conclusion, these results make it possible to infer variable impacts of genetic exchange in populations of predominantly clonal micro-pathogens. Moreover, our results reveal different problems of MLST to determine the genetic structure in these organisms that should be considered.","palabras_clave":"GENETIC EXCHANGE|POPULATION GENETICS|MLST|ASPERGILLUS FUMIGATUS|CANDIDA ALBICANS|CANDIDA GLABRATA|TRYPANOSOMA CRUZI|LEISHMANIA|FUSARIUM SOLANI|BLASTOCYSTIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39876,"idioma_id":4,"titulo":"Identification of N-benzylacetamide as a major component of human plasmatic metabolic profiling of benznidazole","resumen":"Chagas disease is an endemic infection in Latin America with a high health impact. Caused by the parasite Trypanosoma cruzi, it has expanded to non-endemic regions such as North America and European countries via immigration of infected people. This infectious disease has been rising in the ranking of international health priorities due to the growing migration flows from endemic to non-endemic areas. Benznidazole (BZN), a nitroheterocyclic drug, is one of the two trypanocidal drugs currently in clinical use, associated with significant adverse drug reactions (ADRs). Mammalian metabolism of BNZ has been poorly studied, including the potential role of metabolites on both toxicity and anti-parasitic activity. High-resolution UPLC\/MS\/MS was used to analyze three plasma samples obtained from pediatric patients under BNZ treatment in steady state. Spectroscopic and structural criteria were applied to identify BNZ and accompanying substances from chromatographic signals. From all detected species, two can be undoubtedly associated with the BNZ and N-benzylacetamide molecules, the second one being a fragment of the parent drug (BZN). From the obtained results, two hypotheses could be formulated. The first one is to relate the presence of N-benzyl acetamide with the hepatic metabolism of BNZ. The second hypothesis has to do with the possible trypanocidal activity of this metabolite, as well as its role in the development of side effects, associated with the pharmacotherapy. Complementary studies should be carried out to determine the possible association of this metabolite with the BNZ treatment stages, patient?s clinical features, ADRs, and trypanocidal effectiveness.","palabras_clave":"BENZNIDAZOL|CHAGAS DISEASE|METABOLITE|NITROCOMPOUNDS|PEDIATRIC PHARMACOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39877,"idioma_id":4,"titulo":"Cytogenetics analyses among populations of the fish Iheringichtys labrosus (Kröyer, 1874) (Siluriformes, Pimelodidae). Karyotype analysis, C- banding and AgRONs distribution","resumen":"Karyotypic data on Iheringichthys labrosus from several populations of Paraná River\/Argentina are presented. The diploid number was 2n=56 and the karyotype consisted of 42m\/sm + 14st\/a (NF= 98). The AgNORs were observed in telomeres of the long arm of a st\/a chromosome pair. These sites were also positive after C-banding. Heterochromatin was observed in the telomeric position in some chromosomal pairs and can be found in one or both metacentric chromosome arms. The obtained results were compared with those reported for different populations from Brazilian rivers and the similarity among them was evident. However, discordant chromosome formulae and karyotype features between samples should be carefully taken because, in some cases, they seem to be more technical artifacts than real differences.","palabras_clave":"PIMELODIDAE|I. labrosus|KARYOTYPE CONSERVATISM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39878,"idioma_id":4,"titulo":"Cycling performance and hydriding kinetics of LaNi(5) and LaNi(4.73)Sn(0.27) alloys in the presence of CO","resumen":"We analyzed the sorption cycling behavior of LaNi5 and LaNi4.73Sn0.27 alloys in H2   containing 10 and 100&nbsp;ppm of CO. The effect of temperature was studied   for the Sn-containing alloy. When cycling in the presence of CO, we   found the reaction was strongly retarded due to surface contamination   but no loss of capacity was observed when samples were given enough time   for both absorption and desorption. The retardation was stronger at   lower temperatures and higher CO concentration. The results also   indicate that a fraction of the adsorbed CO is released during the   desorption process. For the Sn-containing alloy, a stationary state is   met after about 10 cycles, with no further degradation occurring past   this point. The retarding factor at 40&nbsp;°C and 100&nbsp;ppm in this condition,   with respect to the kinetics in pure hydrogen, is of about 600.","palabras_clave":"CICLADO|HIDRÓGENO|HIDRUROS|AB5"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39879,"idioma_id":4,"titulo":"Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases","resumen":"One of the major goals in the research of autoimmune diseases is to develop specific therapies to regulate the expression and function of gene products that could contribute to restoring tolerance to self-constituents and replace conventional systemic immunosuppression, which is associated with important undesired side effects. Although significant progress has been made on the understanding of the pathogenesis of autoimmunity, therapies for these ailments have not seen a change. During the last decade, different strategies such as pharmacologic or gene therapy modulation of heme oxygenase-1 (HO-1) and the administration of its metabolic product, carbon monoxide (CO), have been shown to display beneficial immunoregulatory and cytoprotective properties. In different experimental autoimmune conditions, such as Experimental autoimmune encephalomyelitis, type-1 diabetes and systemic lupus erythematosus, genetic or pharmacological modulation of HO-1, as well as delivery of CO have shown to ameliorate disease progression. Furthermore, it has been demonstrated that dendritic cell and monocyte function can be modulated by HO-1 and\/or CO. In this article, recent data related to the immunoregulatory properties of HO-1\/CO will be discussed, focusing on their potential therapeutic use to treat autoimmune diseases.","palabras_clave":"heme-oxygenase 1|immunotherapy|autoimmunity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39880,"idioma_id":4,"titulo":"Effects of spirulina biomass on the technological and nutritional quality of bread wheat pasta","resumen":"The objective of this study was to evaluate the effect of the incorporation of spirulina on technological and nutritional quality of dried pasta. Wheat flour was substituted by spirulina biomass at three levels: 5, 10 and 20 g\/100 g, and a sample without spirulina biomass was made as control. The technological quality was analyzed in terms of cooking properties and texture profile, while pasta surface was observed by confocal microscopy. In addition, protein content, in vitro protein digestibility, phenolic compound content and in vitro antioxidant activity were the major bio-functional characteristics measured. An in vitro starch digestion was performed in order to estimate the glycemic index. Only pasta with 20 g of spirulina \/ 100 g of flour did slightly modify technological quality parameters; microstructure studies revealed the impact of spirulina addition, resulting in a more heterogeneous surface. The glycemic index was not affected by the addition of spirulina. The incorporation of spirulina resulted in an increase of protein content; however, protein digestibility was reduced as microalgae content increased. Pasta with spirulina exhibited high phenolic compounds content and antioxidant activity compared to control pasta, which could be used to enhance the nutritional profile of the product.","palabras_clave":"Spirulina|biomass|pasta"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39881,"idioma_id":4,"titulo":"Automatic Rectum Limit Detection by Anatomical Markers Correlation","resumen":"Several diseases take place at the end of the digestive system. Many of them can be diagnosed by means of different medical imaging modalities together with computer aided detection (CAD) systems. These CAD systems mainly focus on the complete segmentation of the digestive tube. However, the detection of limits between different sections could provide important information to these systems. In this paper we present an automatic method for detecting the rectum and sigmoid colon limit using anovel global curvature analysis over the centerline of the segmented digestive tube in different imaging modalities. The results are compared with the gold standard rectum upper limit through a validation scheme comprising two different anatomical markers: the third sacral vertebra and the average rectum length. Experimental results in both magnetic resonance imaging (MRI) and computed tomography colonography (CTC) acquisitions show the efficacy of the proposed strategy in automatic detection of rectum limits. The method is intended for application to the rectum segmentation in MRI for geometrical modeling and as contextual information source in virtual colonoscopies and CAD systems.","palabras_clave":"Anatomical markers|Colon|Rectum|Computed tomography|Magnetic resonance imaging"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39882,"idioma_id":5,"titulo":"Avispas exóticas en la Patagonia: la importancia de la ecología  de invasiones en el manejo de plagas.","resumen":"El manejo integrado de plagas (MIP) se basa en el conocimiento de la ecología de las especies problema. Se ha sugerido que cuando las plagas son especies invasoras, la comprensión del proceso de invasión puede mejorar aún más nuestra capacidad de control de las mismas. Nuestro objetivo es revisar algunos atributos ecológicos y comportamentales claves en el proceso de invasión de la avispa de los pinos Sirex noctilio y de la avispa chaqueta amarilla Vespula germanica, y discutir sus implicancias sobre las acciones de manejo implementadas en el N.O. de la Patagonia Argentina. Investigaciones previas identificaron los factores determinantes del éxito de invasión como la demografía, los atributos de la comunidad receptora y el papel de los disturbios, para éstas y otras especies invasoras. Aquí, ampliamos ese conocimiento focalizándonos en aquellos aspectos ecológicos y conductuales característicos de las distintas etapas del proceso de invasión. Mientras las acciones de control para la avispa de los pinos tuvieron carácter regional y forman parte de un plan de manejo establecido, para la chaqueta amarilla las medidas son de carácter local y sin coordinación espacio-temporal. En ambos casos, y pese a las acciones ejecutadas, las especies avanzaron geográficamente, se establecieron con éxito y generaron impactos importantes en nuevas áreas. Sugerimos que los limitados alcances en términos de eficiencia de control de las poblaciones son, en parte, consecuencia de acciones diseñadas e implementadas con una escasa contemplación de los atributos ecológicos y comportamentales claves de estas especies.","palabras_clave":"SIREX NOCTILIO|VESPULA GERMANICA|AVISPAS INVASORAS|HIMENÓPTEROS SOCIALES|MANEJO INTEGRADO DE PLAGAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39883,"idioma_id":4,"titulo":"Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells","resumen":"Human respiratory syncytial virus (hRSV) is the leading cause of bronchiolitis and pneumonia in young children worldwide. The recurrent hRSV outbreaks and reinfections are the cause of a significant public health burden and associate with an inefficient antiviral immunity, even after disease resolution. Although several mouse- and human cell-based studies have shown that hRSV infection prevents naïve T-cell activation by antigen-presenting cells, the mechanism underlying such inhibition remains unknown. Here, we show that the hRSV nucleoprotein (N) could be at least partially responsible for inhibiting T-cell activation during infection by this virus. Early after infection, the N protein was expressed on the surface of epithelial and dendritic cells, after interacting with trans-Golgi and lysosomal compartments. Further, experiments on supported lipid bilayers loaded with peptide-MHC (pMHC) complexes showed that surface-anchored N protein prevented immunological synapse assembly by naive CD4(+) T cells and, to a lesser extent, by antigen-experienced T-cell blasts. Synapse assembly inhibition was in part due to reduced T-cell receptor (TCR) signaling and pMHC clustering at the T-cell-bilayer interface, suggesting that N protein interferes with pMHC-TCR interactions. Moreover, N protein colocalized with the TCR independently of pMHC, consistent with a possible interaction with TCR complex components. Based on these data, we conclude that hRSV N protein expression at the surface of infected cells inhibits T-cell activation. Our study defines this protein as a major virulence factor that contributes to impairing acquired immunity and enhances susceptibility to reinfection by hRSV.","palabras_clave":"Virus|T cells|immunity|synapsis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39884,"idioma_id":4,"titulo":"Electroejaculation Increases Low Molecular Weight Proteins in Seminal Plasma Modifying Sperm Quality in Corriedale Rams","resumen":"This study was conducted to evaluate the effect of seminal collection method (artificial vagina or electroejaculation) on the protein composition of seminal plasma and sperm quality parameters in Corriedale rams. To address this question, we assessed the effect of seminal collection method on motility, plasma membrane integrity and functionality, mitochondrial functionality and the decondensation state of nuclear chromatin in sperm cells. Volume, pH, osmolarity, protein concentration, total protein content and protein profile using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and 2-D polyacrylamide electrophoresis of seminal plasma collected with artificial vagina and electroejaculation were also analysed. The main findings from this study were that ejaculates obtained with electroejaculation had (i) a higher number of spermatozoa with intact plasma membrane and functional mitochondria and (ii) a higher proportion of seminal plasma, total protein content and relative abundance of low molecular weight proteins than ejaculates obtained with artificial vagina. Five of these proteins were identified by mass spectrometry: binder of sperm 5 precursor; RSVP14; RSVP22; epididymal secretory protein E1 and clusterin. One protein spot with molecular weight of approximately 31 kDa and isoelectric point of 4.8 was only found in the seminal plasma from electroejaculation.","palabras_clave":"ram|sperm|seminal plasma"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39885,"idioma_id":4,"titulo":"How slow RNA Polymerase II elongation favors alternative exon skipping","resumen":"Splicing is functionally coupled to transcription, linking the rate of RNA polymerase II (Pol II) elongation and the ability of splicing factors to recognize splice sites (ss) of various strengths. In most cases, slow Pol II elongation allows weak splice sites to be recognized, leading to higher inclusion of alternative exons. Using CFTR alternative exon 9 (E9) as a model, we show here that slowing down elongation can also cause exon skipping by promoting the recruitment of the negative factor ETR-3 onto the UG-repeat at E9 3' splice site, which displaces the constitutive splicing factor U2AF65 from the overlapping polypyrimidine tract. Weakening of E9 5' ss increases ETR-3 binding at the 3' ss and subsequent E9 skipping, whereas strengthening of the 5' ss usage has the opposite effect. This indicates that a delay in the cotranscriptional emergence of the 5' ss promotes ETR-3 recruitment and subsequent inhibition of E9 inclusion.","palabras_clave":"mRNA alternative splicing|RNA polymerase II |Pol II elongation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39886,"idioma_id":4,"titulo":"Exploration of liquid chromatographic-diode array data for Argentinean wines by extended multivariate curve resolution","resumen":"Second-order data were measured using high-performance liquid-chromatography with diode array detection (HPLC-DAD) for a number of wine samples, which were directly injected in the HPLC-DAD system without sample pre-treatment. The data were arranged in data matrices whose modes were elution time and UV?visible absorption wavelength, and processed by extended multivariate curve resolution coupled to alternating least squares(MCR?ALS). The individual data matrices were organized in a row-wise augmented data matrix sharing the time subspace, due to the high spectral similarity among several sample components. This required previous time alignment of the chromatograms using a suitable synchronization algorithm, in order to produce a bilinear augmented datamatrix to be processed by MCR?ALS. The latter algorithm led to resolved component chromatogramsand spectra, from which component scores could be estimated, which are proportional to the relative component concentrations in each studied sample. The matrix of sample scoreswas then submitted to principal component analysis, which was applied for data exploration according to grape varietal and geographical origin. The results showed that the present data generation and analysis are useful for the discrimination of all samples of the Malbec varietal from the remaining ones, but achieved partial success regarding geographical origin.","palabras_clave":"Química Analítica|Quimiometría"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39887,"idioma_id":4,"titulo":"Chemometric modeling of organic contaminant sources in  surface waters of a mediterranean river basin","resumen":"Chemometric methods are applied to the analysis and interpretation of large multivariate datasets obtained in environmental monitoring studies. Concentrations of multiple organic compounds were measured in river samples taken from several sampling sites, at various geographical locations, during a number of campaigns and\/or sampling time periods. Samples were collected and analyzed as part of an extensive multi-annual monitoring program from a mediterranean river basin (in Catalonia, at the northeast of Spain) by the Water Quality Regional Agency. Due to the great amount of multivariate data stored inenvironmental databases and to their complexity, chemometric modeling methods such as Principal Component Analysis (PCA) and Multivariate Curve Resolution with Alternating Least-Squares (MCR-ALS) coupled with appropriate mapping representations are proposed for the evaluation of the environmental quality of the studied rivers. Results achieved in this study are intended to be a contribution to water quality assessment and evaluation of contamination of surface waters in river basins, and to support public policies of environmental control and management of the regions under study.","palabras_clave":"Química Analítica|Quimiometría"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39888,"idioma_id":4,"titulo":"Targeting Dendritic Cell Function during Systemic Autoimmunity to Restore Tolerance","resumen":"Systemic autoimmune diseases can damage nearly every tissue or cell type of the body. Although a great deal of progress has been made in understanding the pathogenesis of autoimmune diseases, current therapies have not been improved, remain unspecific and are associated with significant side effects. Because dendritic cells (DCs) play a major role in promoting immune tolerance against self-antigens (self-Ags), current efforts are focusing at generating new therapies based on the transfer of tolerogenic DCs (tolDCs) during autoimmunity. However, the feasibility of this approach during systemic autoimmunity has yet to be evaluated. TolDCs may ameliorate autoimmunity mainly by restoring T cell tolerance and, thus, indirectly modulating autoantibody development. In vitro induction of tolDCs loaded with immunodominant self-Ags and subsequent cell transfer to patients would be a specific new therapy that will avoid systemic immunosuppression. Herein, we review recent approaches evaluating the potential of tolDCs for the treatment of systemic autoimmune disorders.","palabras_clave":"dendritic cells|autoimmunity|tolerance|therapy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39889,"idioma_id":4,"titulo":"Pinning-Dependent Field-Driven Domain Wall Dynamics and Thermal Scaling in an Ultrathin Pt\/Co\/Pt Magnetic Film","resumen":"Magnetic-field-driven domain wall motion in an ultrathin Pt\/Co 0.45 nm\/Pt ferromagnetic film with  perpendicular anisotropy is studied over a wide temperature range. Three different pinning dependent  dynamical regimes are clearly identified: the creep, the thermally assisted flux flow, and the depinning, as  well as their corresponding crossovers. The wall elastic energy and microscopic parameters characterizing  the pinning are determined. Both the extracted thermal rounding exponent at the depinning transition,  &#968;=0.15, and the Larkin length crossover exponent, &#981;=0.24, fit well with the numerical predictions.","palabras_clave":"Magnetic Domain Walls dynamics|Disorder|Out of equilibrium"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39890,"idioma_id":4,"titulo":"Production of equine herpesvirus 1 recombinant glycoprotein D and development of an agar gel immunodiffusion test for serological diagnosis","resumen":"Equine herpesvirus 1 and 4 (EHV-1 and 4) infect most of the world's horses, causing serious clinical illness. Viral glycoproteins have been identified as the immunodominant antigens that generate the antiviral serological responses to EHV-1 and EHV-4 in infected horses. Here, glycoprotein D of EHV-1 was expressed by a recombinant baculovirus, purified and evaluated by a simple agar gel immunodiffusion test (AGID). Compared with virus neutralization, serological analysis by AGID showed good specificity (100%) and sensitivity (99.5%). The estimated Kappa values for repeatability and reproducibility were satisfactory. Thus, this rapid, inexpensive, simple and highly specific AGID test seems to be a valuable alternative tool for serological detection of antibodies against both EHV-1 and EHV-4.","palabras_clave":"Agar gel immunodiffusion test,|Equine herpesvirus 1|Recombinant glycoprotein D|Virus neutralization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39891,"idioma_id":5,"titulo":"Estándares ISO abordados en Congresos de Informática en Argentina (2010-2012), y su aplicación a productos software","resumen":"En este trabajo se expone una indagación documental de algunos estánda-res y modelos de calidad de software, en particular las normas ISO y su abordaje en congresos de la disciplina Informática en el periodo 2010- 2012. El artículo se compone de cuatro secciones. En la primera se sintetiza el contexto en el que se desarrolla el trabajo. En la segunda sección se introduce el concepto de calidad y sus acepciones en la Ingeniería del Software. La tercera muestra algunos estándares ISO, tratadas por equipos de I+D y presentados en congresos nacionales de Informática. Finalmente, se exponen reflexiones preliminares derivadas del estudio.","palabras_clave":"estándares|modelos de calidad|normas ISO|ingenieria web|calidad web"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39892,"idioma_id":5,"titulo":"Sistema virtual para apoyar la elaboración del Trabajo Final de Aplicación en la Universidad Nacional del  Nordeste: diseño, implementación y evaluación.","resumen":"Trabajo Final de Aplicación es una asignatura integradora de la carrera Licenciatura en Sistemas de Información (Facultad de Ciencias Exactas y Naturales y Agrimensura - Universidad Nacional del Nordeste). En este trabajo, se describe el sistema Web para apoyar el desarrollo de la asignatura y su valoración desde la perspectiva de los alumnos del ciclo lectivo 2012.","palabras_clave":"educación superior|informática|trabajos final de graduación,|tecnologías de la información,|sistema Web."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39893,"idioma_id":5,"titulo":"Comprensión lectora en niños de educación primaria que viven en contextos de pobreza: decodificación, conocimiento léxico e inferencias","resumen":"Las condiciones de pobreza inciden negativamente en el desarrollo infantil y, en consecuencia, en los procesos alfabetizadores. Diversos estudios nacionales e internacionales evidenciaron que las condiciones de pobreza tienen consecuencias en el desarrollo cognitivo y en las habilidades necesarias para la comprensión lectora. La comprensión lectora es un proceso que depende del funcionamiento interrelacionado de tres habilidades: decodificación, conocimiento léxico-semántico e inferencias. En esta investigación se estudia la incidencia de las condiciones contextuales de pobreza en las habilidades implicadas en la comprensión lectora. Se realizó un estudio correlacional con una muestra de 94 niños escolarizados de 9-10 años de S. M. de Tucumán. Se evaluaron las condiciones de vida y las habilidades lectoras antes mencionadas. Los resultados mostraron correlaciones moderadas a altas y significativas entre las habilidades lectoras. Este estudio contribuye a la literatura científica previa, ya que los niños con NBS tuvieron un mejor rendimiento que los niños con NBI en estas habilidades, especialmente en las habilidades inferenciales.","palabras_clave":"comprension lectora|niños|pobreza"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39894,"idioma_id":5,"titulo":"Evaluación de accesibilidad en sitios web de dos empresas de una provincia del Nordeste Argentino. Una aproximación empírica","resumen":"En los ultimos años el diseño y desarrollo de sistemas informáticos de calidad ha cobrado importancia tanto para la industria del software como en la academia.","palabras_clave":"accesibilidad|calidad en sistemas de informaciòn|industria del sofware|sector de servicios informáticos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39895,"idioma_id":5,"titulo":"Estudio Preliminar de las expectativas de estudiantes universitarios de una carrera de sistemas en su calidad de pasantes","resumen":"En este trabajo se presenta un estudio preliminar orientado a generar y brindar informaciónreferente al cumplimiento de las expectativas de estudiantes universitarios de la Carrera deLicenciatura en Sistema de Información (L.S.I), quienes se desempeñaron como pasantes enel sector servicio de una ciudad del Nordeste Argentino (NEA) en el periodo que comprendelos años 2003 a 2010. El trabajo se compone de cuatro secciones. En primer lugar, secontextualiza el problema, junto con los objetivos e interrogantes planteados, como asítambién la justificación. Se despliega el marco teórico con los conceptos principales utilizadospara respaldar la presente investigación. La segunda sección presenta una estrategiametodológica cuanti-cualitativa; además se obtuvieron de los estudiantes aportes referentes alpuesto, tarea y formación, surgidas mediante encuestas semi-estructuradas. En la tercerasección se muestra el análisis de los resultados del relevamiento de los datos. Finalizando, seexponen las conclusiones.","palabras_clave":"relaciones laborales|pasantías|carreras de grado, .|informática"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39896,"idioma_id":5,"titulo":"Los Derechos Humanos en Argentina y sus Procesos de subjetivación","resumen":"El saber hacer y el conocimiento acerca de los derechos humanos acumulado durante los últimos 50 años en Argentina, disciplina a los individuos, gubernamentaliza a la población, como así también refiere a los modos de constitución de los sujetos o mecanismos que respectan a los procesos de subjetivación de los argentinos. Nosotros nos aproximamos, en la indagación de los derechos humanos, cómo un dispositivo nos permite pasar del análisis de la gubernamentalidad hacia los modos de constituirse como sujetos en un contexto determinado. Los derechos humanos en la Argentina configuran un foco de experiencia en el que se han configurado numerosos y múltiples sentidos en los ciudadanos.  ","palabras_clave":"Derechos Humanos|Gubernamentalidad|Conocimiento|Subjetivación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39897,"idioma_id":4,"titulo":"Resource segregation in two herbivorous species of mountain lizards from Argentina","resumen":"Lizard assemblages may experience resource partitioning in the spatial,   trophic or temporal dimensions of their niche. Niche segregation does   not always imply competition, and the role of interspecific competition   is better understood when the response of species to the presence or   absence of other species is evaluated. The aim of this study is to   determine daily activity patterns and food consumption in two   phylogenetically related species (Phymaturus roigorum and P. payuniae).   These saxicolous and herbivorous species live in sympatry in the   volcanic region of Payunia, in central-west Argentina. One of these   species can also be found in allopatry, allowing comparative studies on   their lifestyle. We evaluated the temporal daily patterns of both   species and their diet overlap. Although competition is not evident   between the species studied here, it is shown that selectivity towards   different plant species and the time schedule of foraging are the   primary mechanisms that promote the coexistence of these lizards. Daily   basking activity, however, was similar in both species.","palabras_clave":"PAYUNIA REGION|FOOD SEGREGATION|ACTIVITY PATTERN|PHYMATURUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39898,"idioma_id":4,"titulo":"Prolonged larval development in the Critically Endangered Pehuenche's frog Alsodes pehuenche: implications for conservation","resumen":"Overwintering is an anuran strategy to survive in cold-temperate climates. Those                 aquatic species that withstand harsh conditions and short growing seasons are                 candidates for having long larval periods. Prolonged larval development, which includes overwintering for more than two years, has been reported for North-American                 and Euro-Asiatic species, but this strategy has been poorly studied in the Southern                 Hemisphere. Alsodes pehuenche is an endemic frog from the high Andes mountains of                 Argentina and Chile, recently categorized as Endangered by the Asociación                 Herpetológica Argentina (AHA) and as Critically Endangered by the International                 Union for Conservation of Nature (IUCN). We studied egg laying in this species and its                 larval development by marking tadpoles with elastomers. We found that eggs are laid in                 clumps at the beginning of summer. The larval cycle includes four winters, although a                 fifth winter should not be ruled out. This is the first study that demonstrates a long                 larval development (four winters) in South-American species and has important                 implications for conservation biology.","palabras_clave":"LIFE CYCLE|CENTRAL ANDES|ENDEMISM|OVERWINTERING TADPOLES|EGG LAYING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39899,"idioma_id":5,"titulo":"UNA PERSPECTIVA PSICOSOCIAL EN TORNO A LAS ESTRATEGIAS DE POLITIZACIÓN EN CONFLICTOS ASIMÉTRICOS","resumen":"En este artículo se explicarán un conjunto de tradiciones relativas a los enfoques de las concepciones políticas contemporáneas desde una perspectiva psicosocial. Nos interesa dar cuenta de algunos aportes que problematizan la acción política de grupos y comunidades sociales, analizando discursivamente su posicionamiento y subjetivación. Asimismo, buscamos dar cuenta de las transformaciones en su relación con otras instancias sociales y, su distinción y complementariedad con las políticas públicas vigentes. Los casos que aquí presentamos son de la empresa recuperada IMPA (Industrias Metalúrgicas y Plásticas Argentinas) del barrio de Almagro y de la cooperativa de promotores ambientales (ex cartoneros) de Villa Crespo de la CABA, El CorreCamino, ambos de la Ciudad de Buenos Aires, con el objeto de dar cuenta de los aspectos innovadores de movimientos que realizan prácticas de resistencia frente a condiciones sociales y estructurales desventajadas. El método es una Investigación Acción Participativa (IAP)","palabras_clave":"ACCIÓN POLÍTICA|SUBJETIVIDAD|CONFLICTOS ASIMÉTRICOS|INVESTIGACIÓN ACCIÓN PARTICIPATIVA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39900,"idioma_id":4,"titulo":"Maternal administration of flutamide during late gestation affects brain and reproductive organs development in the rat male offspring","resumen":"We have previously demonstrated that male rats exposed to stress during the last week of gestation present age-specific impairments of brain development. Since the organization of the fetal developing brain is subject to androgen exposure and prenatal stress was reported to disrupt perinatal testosterone surges, the aim of this research was to explore whether abnormal androgen concentrations during late gestation affects the morphology of the prefrontal cortex (PFC), hippocampus (HPC) and ventral tegmental area (VTA), three major areas that were shown to be affected by prenatal stress in our previous studies. We administered 10-mg\/kg\/day of the androgen receptor antagonist flutamide (4&#8242;nitro-3&#8242;-trifluoromethylsobutyranilide) or vehicle injections to pregnant rats from days 15?21 of gestation. The antiandrogenic effects of flutamide were confirmed by the analysis of androgen-dependent developmental markers: flutamide-exposed rats showed reduced anogenital distance, delay in the completion of testis descent, hypospadias, cryptorchidism and atrophied seminal vesicles. Brain morphological studies revealed that prenatal flutamide decreased the number of MAP2 (a microtubule-associated protein type 2, present almost exclusively in dendrites) immunoreactive neuronal processes in all evaluated brain areas, both in prepubertal and adult offspring, suggesting that prenatal androgen disruption induces long-term reductions of the dendritic arborization of several brain structures, affecting the normal connectivity between areas. Moreover, the number of tyrosine hydroxylase (TH)-immunopositive neurons in the VTA of prepubertal offspring was reduced in flutamide rats but reach normal values at adulthood. Our results demonstrate that the effects of prenatal flutamide on the offspring brain morphology resemble several prenatal stress effects suggesting that the mechanism of action of prenatal stress might be related to the impairment of the organizational role of androgens on brain development.","palabras_clave":"PRENATAL FLUTAMIDE|MALE RATE OFFSPRING|PREFRONTAL  CORTEX|HIPPOCAMPUS|VENTRAL TEGMENTAL AREA|TYROSINE HYDROXYLASE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39901,"idioma_id":4,"titulo":"Physiological Response of Multiple Contrasting Rice (Oriza sativa L.) Cultivars to Suboptimal Temperatures","resumen":"        The physiological response of  multiple rice cultivars, eighteen initially and eight cultivars later on, to  suboptimal temperatures (ST) conditions was investigated in laboratory and  outdoor experimental conditions. Treatment with ST decreased growth in  different extents according to the cultivar and affected the PSII performance,  determined by chlorophyll &#64258;uorescence fast-transient test, and stomatal  conductance,&nbsp;&nbsp;&nbsp; regardless the&nbsp; experimental&nbsp;&nbsp;  condition.&nbsp; Two&nbsp;&nbsp; groups&nbsp;&nbsp;  of cultivars could be distinguished on the base of their growth and  physiological parameters.         The&nbsp; group&nbsp;  of&nbsp; cultivars&nbsp; presenting&nbsp;  higher&nbsp; growths&nbsp; displayed&nbsp;  optimal&nbsp; JIP&nbsp; values, and higher instantaneous water use  ef&#64257;ciency (WUE ), due to a lower Gs under i ST, unlike cultivars showing lower  growth values, which presented worse JIP values&nbsp;  and&nbsp; could&nbsp; not&nbsp;  adjust&nbsp; their&nbsp; Gs&nbsp;  and&nbsp; hence&nbsp; their&nbsp;  WUEi.&nbsp; In&nbsp; this&nbsp;  work,&nbsp; we detected at least two  cultivars with superior tolerance to ST than the cold tolerant referent  Koshihikari. These cultivars could be used as parents or tolerance donors in  breeding for new crop varieties. On other hand, positive and signi&#64257;cant correlations  between data obtained from laboratory and outdoor experiments suggest that  laboratory measurements of most of the above mentioned parameters would be  useful to predict the response of rice cultivars to ST outdoor.     ","palabras_clave":"instantaneous water use efficiency|JIP test|net photosynthesis rate|Oryza sativa|stomatal conductance|suboptimal temperatures"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39902,"idioma_id":4,"titulo":"Diels-Alder Reactions of Pinacol Alkenylboronates: An experimental and theoretical study","resumen":"We have studied the Diels-Alder reactions of pinacol alkenylboronates   with cyclopentadiene under two different conditions: thermal heating at   170 °C in a pressure tube and with catalytic TFA (5 mol%) at 80 °C.   Yields varied significantly from system to system and also for the   uncatalyzed and catalyzed methodologies. Moderate to excellent   exo-stereoselectivities were obtained in all cases. The theoretical   study of the thermal reactions shed some light into the intriguing   substituent effects observed experimentally. A variety of substituted   5-norbornen-2-ols were easily generated by subsequent in-situ oxidation   of the cycloadducts with alkaline hydrogen peroxide.","palabras_clave":"DIELS-ALDER|BORONATE|DFT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39903,"idioma_id":4,"titulo":"In vitro and in vivo experiments with iron oxide nanoparticles functionalized with DEXTRAN or polyethylene glycol for medical applications: Magnetic targeting","resumen":"In this research work, DEXTRAN- and polyethylene glycol (PEG)-coated iron-oxide superparamagnetic nanoparticles were synthetized and their cytotoxicity and biodistribution assessed. Well-crystalline hydrophobic Fe3O4 SPIONs were formed by a thermal decomposition process with d = 18 nm and sigma = 2 nm; finally, the character of SPIONs was changed to hydrophilic by a post-synthesis procedure with the functionalization of the SPIONs with PEG or DEXTRAN. The nanoparticles present high saturation magnetization and superparamagnetic behavior at room temperature, and the hydrodynamic diameters of DEXTRAN- and PEG-coated SPIONs were measured as 170 and 120 nm, respectively. PEG- and DEXTRAN-coated SPIONs have a Specific Power Absorption SPA of 320 and 400 W\/g, respectively, in an ac magnetic field with amplitude of 13 kA\/m and frequency of 256 kHz. In vitro studies using VERO and MDCK cell lineages were performed to study the cytotoxicity and cell uptake of the SPIONs. For both cell lineages, PEG- and DEXTRAN-coated nanoparticles presented high cell viability for concentrations as high as 200 lg\/mL. In vivo studies were conducted using BALB\/c mice inoculating the SPIONs intravenously and exposing them to the presence of an external magnet located over the tumour. It was observed that the amount of PEG-coated SPIONs in the tumor increased by up to 160% when using the external permanent magnetic as opposed to those animals that were not exposed to the external magnetic field.","palabras_clave":"SPIONS quantification|tumors|SPIONs biodistribution|magnetic nanoparticles|hyperthermia|SPIONS biocompatibility|cell uptake|superparamagnetism|mice"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39904,"idioma_id":4,"titulo":"Modeling and experimentation with asymmetric rigid bodies. A variation on disks and inclines","resumen":"We study the ascending motion of a disk rolling on an incline when its centre of mass lies outside the disk axis. The problem is suitable as laboratory project for a first course in mechanics at the undergraduate level and goes beyond typical textbook problems about bi-dimensional rigid body motions. We develop a theoretical model for the disk motion based on mechanical energy conservation and compare its predictions with experimental data obtained by digital video recording. Using readily available resources, a very satisfactory agreement is obtained between the model and the experimental observations. These results complement previous ones that have been reported in the literature for similar systems.","palabras_clave":"MODELING|EXPERIMENTATION|RIGID BODY MOTION|DIGITAL VIDEO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39905,"idioma_id":5,"titulo":"Localización de receptores de progesterona isoforma A en útero de cerdas no gestantes y placenta materna durante la gestación temprana","resumen":"El mantenimiento de la preñez requiere de interacciones recíprocas entre el conceptus y el endometrio. Las hormonas esteroides producidas por el ovario así como las placentarias actúan sobre el endometrio uterino regulando la diferenciación y función de las células uterinas. Durante la preñez, la progesterona (P4) producida por el cuerpo lúteo, cumple una función de vital importancia en la preparación, recepción de embriones y mantenimiento de la gestación. Los efectos de la P4 están mediados por la interacción de la hormona con sus receptores intracelulares específicos. Por eso el objetivo de este estudio fue investigar la localización de los receptores de progesterona isoforma A (RPA) en cortes histológicos de útero de cerdas no gestantes y placenta materna de cerdas gestantes  y la concentración de  P4 a nivel sistémico. Se utilizaron cerdas mestizas no gestantes en fase folicular y gestantes de 5, 17 y 35 días (n=16). Se determinó la localización de los RPA por inmunohistoquimica con anticuerpos monoclonales. En cerdas no gestantes y de 5 días de gestación se observó expresión del RPA en núcleos de epitelio, glándulas uterinas, estroma y miometrio. En tanto que a los 17 días de gestación la expresión se halló en núcleos de glándulas, estroma y miometrio, mientras que a los 35 días de gestación la expresión se observó en estroma y miometrio. Hallamos un aumento de la concentración de P4 a nivel sistémico a los 17 días de gestación. Dado que la P4 es imprescindible para el mantenimiento de la preñez y es el ligando especifico para las diferentes isoformas del RP, la diferencia entre la expresión de los RPA y la concentración sistémica de la hormona se  explicaría por el rol de RPA como factor de transcripción inhibidor de la expresión génica de la P4.","palabras_clave":"Porcinos|Placenta|Progesterona|RPA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39906,"idioma_id":4,"titulo":"Ultraviolet-B-induced stomatal closure in Arabidopsis is regulated by the UV RESISTANCE LOCUS8 photoreceptor in  a nitric oxide-dependent mechanism","resumen":"UV RESISTANCE LOCUS8 (UVR8) signaling involves CONSTITUTIVELY PHOTOMORPHOGENIC1, the ELONGATED HYPOCOTYL5 (HY5) transcription factor, and the closely related HY5 HOMOLOG. Some UV-B responses mediated by UVR8 are also regulated by nitric oxide (NO), a bioactive molecule that orchestrates a wide range of processes in plants. In this study, we investigated the participation of the UVR8 pathway and its interaction with NO in UV-B-induced stomatal movements in Arabidopsis (Arabidopsis thaliana). Stomata in abaxial epidermal strips of Arabidopsis ecotype Landsberg erecta closed in response to increasing UV-B fluence rates, with maximal closure after 3-h exposure to 5.46 &#956;mol m?2 s?1 UV-B. Both hydrogen peroxide (H2O2) and NO increased in response to UV-B, and stomatal closure was maintained by NO up to 24 h after the beginning of exposure. Stomata of plants expressing bacterial NO dioxygenase,","palabras_clave":"PHOTOMORPHOGENIC1|HY5 HOMOLOG|NITRIC OXIDE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39908,"idioma_id":5,"titulo":"Distribución vertical del banco de semillas de Euphorbia davidii Subils en lotes agrícolas de la zona centro de la Provincia de Buenos Aires, Argentina","resumen":"Euphorbia davidii Subils, es una maleza anual que está presente en la zona centro de la provincia de Buenos Aires, Argentina. Se realizaron estudios para determinar el banco de semillas de esta especie y su distribución vertical en lotes agrícolas de Azul y Olavarría. Se extrajeron 240 muestras de suelo, provenientes de 60 puntos distribuidos al azar, a cuatro niveles de profundidad: 0-5 cm, 5-10 cm, 10-15 cm y 15-20 cm. Las extracciones se realizaron dos veces al año, en mayo y en septiembre. Las muestras fueron procesadas y las semillas separadas por tamizado en húmedo. Se evaluó germinación y viabilidad mediante la prueba de trifeniltetrazolio. Se cuantificaron 30.000 y 15.000 semillas m-2, para los lotes de Azul y Olavarría, respectivamente. En Olavarría, el 79% de las semillas se encontraron de 0-5 cm, de profundidad, el 14%, de 5-10 cm y el 7% restante de 10-20 cm. En Azul se observó una distribución vertical más homogénea. El 55 % de las semillas se encontraron de 0-5 cm de profundidad, un 24% de 5-10 cm, el 16% de 10-15 cm y el 5% en el muestreo más profundo. Las diferencias en la distribución se asociaron al manejo de los lotes. En ambas localidades la viabilidad de semillas, provenientes del estrato superficial, superó el 70%. Las semillas de estratos superficiales recolectadas en el lote de Olavarría, inmediatamente después de la dehiscencia, presentaron dormición, en cambio en las semillas provenientes del lote de Azul para el mismo momento de muestreo, no se observó dormición.","palabras_clave":"EUPHORBIA DAVIDII|LABRANZA|PROPÁGULOS|VIABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39909,"idioma_id":4,"titulo":"Growth, nutrient uptake and symbiosis with  rhizobia and arbuscular mycorrhizal fungi  in Lotus tenuis plants fertilized with different phosphate sources and inoculated with the phosphate-solubilizing bacterium Pantoea eucalypti M91","resumen":"                    Background and Aims: The aim of  this work was to evaluate the ability of P fertilization and phosphate-solubilizing  bacteria (PSB) inoculation to promote the growth of L. tenuis in typical  soils of the Salado River Basin (Argentina) with low P availability.                     Methods:  Aboveground biomass and P and N levels were evaluated in field-grown L.  tenuis plants inoculated with Pantoea eucalypti M91, either without  fertilization or in combination with phosphate rock and triple superphosphate  (TSP). The impact of P fertilization and inoculation on the symbiotic  interactions between L. tenuis and native rhizobia bacteria and  arbuscular mycorrhizal fungi was also evaluated.                     Results: Inoculation with M91 increased the L. tenuis biomass production and P  concentration in shoots, at an early stage of plant growth. The combined  treatment of inoculation with M91 and TSP significantly increased the P and N  content in shoots compared to non-inoculated plants, fertilized or not.  P. eucalypti M91 was found to endophytically colonize roots and  leaves of L. tenuis plants grown in vitro and also under field conditions.                    Conclusions: The results  suggesting that inoculation of L. tenuis  with the PSB such as P. eucalypti M91  strain might allow more efficient use of N and P and a more sustainable option  for grasslands producers from the Salado River Basin, in order to reduce costs  and avoid increased levels of P insoluble in soils.  ","palabras_clave":"LOTUS TENUIS|PHOSPHATE-SOLUBILIZING BACTERIA|SOIL P AVAILABILITY|RHIZOBIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39910,"idioma_id":5,"titulo":"El debate sobre la sostenibilidad desde la posición del pensamiento ambiental crítico","resumen":"El presente artículo reflexiona sobre el debate generado en torno al concepto de sostenibilidad en el marco de crisis estructural que caracteriza al sistema global, considerando la posición adoptada desde el pensamiento ambiental crítico. El hilo conductor se centra en dos ejes principales, el primero se focaliza en la indefinición conceptual y el debate teórico en que se inscribe la idea de sostenibilidad, teniendo en cuentas las características del contexto del cual emerge. El segundo eje profundiza en la necesidad de reflexionar sobre su ambigüedad conceptual, poniendo de manifiesto las contradicciones que implica su aplicación a partir de una lectura crítica de los componentes ideológicos implícitos en la crisis ecológica. Se propone un enfoque teórico de carácter sociocrítico, poniendo énfasis en el enfoque crítico, posición desde la cual la problemática de la sostenibilidad no puede desvincularse de los mecanismos y relaciones de poder que la atraviesan. El abordaje metodológico contempla la aplicación de técnicas de carácter cualitativo, entre las que destacan: el análisis bibliográfico y documental, la triangulación de fuentes de información y la autorreflexión epistemológica. El análisis desarrollado intenta realizar un aporte tendiente a enriquecer los argumentos teóricos que constituyen el campo de las ciencias socioambientales.","palabras_clave":"Indefinición conceptual|Pensamiento ambiental crítico|Incertidumbre|Crisis estructural"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39911,"idioma_id":5,"titulo":"Estrategias ejecutivas de búsqueda, recuperación y cambio en la fluidez verbal","resumen":"Las tareas de fluidez verbal suelen dividirse en semántica -evocar palabras de una categoría- y fonológica -evocar palabras que empiecen con una determinada letra-, y conllevan un tiempo limitado. En dichas tareas intervienen la búsqueda y la recuperación de palabras -lo cual requiere flexibilidad cognitiva, memoria de trabajo e inhibición (componente ejecutivo)- y la organización, capacidad e integridad del almacén léxico-semántico (componente asociativo). El primer componente se manifiesta en la cantidad de subagrupamientos (clusters) y de saltos entre ellos (switching) que un sujeto pueda hacer, y el segundo, en el tamaño de los clusters. Para estudiarlos se administraron tareas de fluidez verbal semántica (animales) y fonológica (letra p) a 133 niños de 1°, 3° y 5° año de EPB de Mar del Plata. Se halló un aumento del control cognitivo en 3er año, asociado a una mejor fluidez, pero no se encontraron cambios en el componente asociativo.","palabras_clave":"fluidez verbal|flexibilidad cognitiva|clusters|switching"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39912,"idioma_id":5,"titulo":"Investigación en Educación Ambiental. Problematizando la Temática Ambiental en la sociedad contemporánea","resumen":"El presente artículo se focaliza en tres ejes principales que actúan como hilo conductor de la presentación y a partir de los cuales se desarrolla el tema central de la ponencia. En el primer eje se reflexiona sobre el campo de la Educación Ambiental, considerando la pluralidad discursiva y los diferentes enfoques desde los que se estructura su conformación como campo disciplinar en formación, haciendo especial hincapié en las características del enfoque crítico. El segundo eje gira en torno a las contradicciones que se vislumbran entre la emergencia de la Educación Ambiental y los resultados obtenidos hasta el momento actual, considerando los mecanismos que han condicionado su resolución, teniendo en cuenta aquellos elementos que pueden considerarse bien como constitutivos de la crisis ambiental, o como elementos válidos para la conformación de una relación alternativa entre sociedad-naturaleza, a lo largo del proceso de racionalización de la sociedad occidental. En el tercer eje se profundiza en los retos y perspectivas a los que se enfrenta la Educación Ambiental en la sociedad contemporánea, considerando su relación con aquellas dimensiones que se visualizan como el marco categorial del contexto social en que se desarrolla la profundización de la crisis ambiental. Para finalizar se dejan planteados algunos interrogantes con relación a los temas abordados y al futuro de la Educación Ambiental como respuesta educativa a la problemática ambiental.","palabras_clave":"EDUCACIÓN AMBIENTAL|SOCIEDAD CONTEMPORÁNEA|RETOS Y PERSPECTIVAS|INTERROGANTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39913,"idioma_id":4,"titulo":"Inhibition of the phytopathogenic fungus Fusarium proliferatum by volatile compounds produced by Pseudomonas","resumen":"The Fusarium head blight of grain cereals is a significant disease worldwide. In Argentina, high levels of contamination with Fusarium proliferatum have been found in crops. Many strains of the Pseudomonas genus antagonize the growth of fungi by different mechanisms, such as the production of antibiotics, siderophores, volatiles, and extracellular enzymes. In this work, we have designed a new system for studying the growth inhibition of F. proliferatum?namely by volatile compounds produced by Pseudomonas fluorescens MGR12. In both rich and minimal media, the bacterium released volatiles that negatively affected the mycelial growth of that phytopathogenic fungus. These bacterial compounds were analyzed by gas chromatography?mass spectrometry, but only a few could be identified by comparing their mass spectra with the libraries of the National Institutes of Standards and Technology MS search.","palabras_clave":"BIOCONTROL|FUSARIUM|PSEUDOMONAS|VOLATILES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39914,"idioma_id":5,"titulo":"La competitividad de América Latina en el comercio de servicios basados en el conocimiento","resumen":"        En este  trabajo se presenta un análisis dinámico de la competitividad de América Latina  en los ?servicios intensivos en conocimiento? (SIC), utilizando una metodología  del estilo TradeCAN &#8722;desarrollada por la Comisión Económica para América Latina  y el Caribe (CEPAL)&#8722; para evaluar la competitividad de un país mediante sus  exportaciones a los mercados de mayor crecimiento, pero aplicada principalmente  al comercio de bienes. Los resultados sugieren que si bien varios países  latinoamericanos avanzaron en los segmentos de SIC y muestran ventajas  comparativas positivas, existe aún un bajo porcentaje de ?estrellas nacientes?  (sectores dinámicos donde se gana participación de mercado) y un relativamente  alto nivel de ?oportunidades perdidas? (sectores dinámicos donde se pierde  peso), lo que se corresponde con las debilidades competitivas de la región y plantea  la necesidad de políticas para potenciar los factores aventajados y remover los  obstáculos que traban una mejor inserción en los mercados de SIC.  ","palabras_clave":"Competitividad|Servicios|América Latina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39915,"idioma_id":5,"titulo":"La mirada subyacente. Los obstáculos ideológicos en el devenir jurídico.","resumen":"La tradición jurídica ha marcado históricamente una tendencia signada por la reproducción autómata de los contenidos normativos, y la consecuente contribución a perpetuar los intereses allí cristalizados. El desafío de nuestros tiempos radica en evidenciar el conglomerado de poderes que subyacen tanto en la creación como en la aplicación de las normas jurídicas. En cause de alcanzar tal propósito, resulta ineludible revelar los obstáculos ideológicos que detienen el análisis crítico y condenan al derecho a permanecer en un perfil netamente conservador. La mirada subyacente contribuye desde la incomodidad, propia de toda perspectiva rebelde, a devolverle a nuestra disciplina su enorme potencialidad transformadora, colocándola al servicio de las necesidades sociales y de la efectividad de los derechos humanos.","palabras_clave":"IUSILOSOFÍA|IDEOLOGÍA|SUBYACENTE|CRÍTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39916,"idioma_id":4,"titulo":"Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation","resumen":"Multiple sclerosis (MS) is a progressive degenerative disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal loss. While the majority of MS patients experience relapsing-remitting symptoms followed by a secondary progressive phase, about 10?15% patients exhibit a primary progressive disease involving continuous progression from its onset. Here we review the role of lectin?glycan recognition systems, including those concerning siglecs, C-type lectins and galectins in the pathogenesis of MS and experimental autoimmune encephalomyelitis. Particularly, we will focus on the role of galectins in the fate of T cells, dendritic cells and CNS cell populations. Understanding the regulatory circuits governed by lectin?glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS.","palabras_clave":"Multiple sclerosis|Glycans|Siglecs|C-type lectins|Galectins"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39917,"idioma_id":5,"titulo":"Nonlinear Control of a Buck Converter Feeding a Constant Power Load","resumen":"In this paper a nonlinear control strategy for  controlling a dc\/dc Buck converter feeding a constant power load is  proposed. A feedback controller is combined with a feedforward  strategy. A nonlinear reduced order observer is used for estimating  the value of the power load and its time derivative. These estimated  values are fed forward to the nonlinear feedback controller whose  design is based on feedback linearization method. The proposed  controller is tested via simulations and also, experimental results  are presented.","palabras_clave":"CPL|nonlinear control|feedforward compensation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39918,"idioma_id":5,"titulo":"Generalidades sobre la Hematología de anfibios anuros","resumen":"    En el presente  trabajo se presenta generalidades de la constitución de la sangre de anfibios,  base fundamental de la tesis doctoral titulada: ?Caracterización hematológica  de especies de anfibios anuros con distribución en los ecosistemas del litoral  fluvial argentino (Provincias de Entre Ríos y Santa Fe). Potencialidad de su  utilización como biomarcadores? (FBCB-UNL), señalando algunos de los resultados  de la caracterización hematológica de individuos (larvas y adultos) de quince  especies pertenecientes a cinco de las seis familias de anfibios anuros&nbsp; con distribución en las áreas riparias del  río Paraná.  ","palabras_clave":"ANUROS|ERITROCITOS|LEUCOCITOS|TROMBOCITOS|HEMOPARÁSITOS|BIOMARCADORES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39919,"idioma_id":4,"titulo":"Composition of the diet of Netta peposaca (Birds: Anseriformes) in Santa Fe province, Argentina","resumen":"We examined the diet of the Rosy-billed Pochard, Netta peposaca (Vieillot, 1816), (n = 59) during the autumn of 2010 in Santa Fe province, Argentina. Were analyzed a total of 59 ducks (n = 37 females and n = 22 males) to assess their gastrointestinal contents. The trophic spectrum was composed of 16 taxa (plant fraction: animal fraction 9 and 7). The contribution of each food category estimated using the IRI was: Echynochloa sp. (Poaceae) = 4301, Polygonum sp. (Polygonaceae) = 956, and unidentified graminoid species = 53 (females: Echynochloa sp. = 4313, Polygonum sp. = 1095 and males: Echynochloa sp. = 5522, Polygonum sp. = 814). No significant differences were found between females and males in diet composition (Fisher´s test, p < 0.05). Moreover, the diversity index (H´) was significantly (Mann-Whitney, p < 0.05) different between sexes. The Rosy-billed Pochard showed a predominantly phytophagous feeding habit in autumn. Likewise, this is the first contribution on the sexual differences in the feeding biology of the Rosy-billed Pochard.","palabras_clave":"Dieta |Netta peposaca"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39920,"idioma_id":4,"titulo":"Biological endpoints, enzyme activities, and blood cell parameters in two anuran tadpole species in rice agroecosystems of mid-eastern Argentina","resumen":"Different biological variables of tadpoles, includingsurvival, development and growth rates, andbiomarkers [cholinesterases, glutathione-S-transferases(GST), and blood cell morphology] were evaluated intwo anuran species, Scinax squalirostris (Hylidae) andLeptodactylus mystacinus (Leptodactylidae), using in situexperimental chambers in a rice field (RF) sprayed withinsecticide Lambda-cyhalothrin (LTC) by aircraft inSanta Fe Province, Argentina. We found a significantdecrease in body weight (0.62±0.04 g) of L. mystacinusand an increased development rate of S. squalirostris inindividuals from RF (41±1; Gosner) with respect toindividuals from the reference site (RS: 0.93±0.04 gand 37±0; respectively). In S. squalirostris, individualsfrom RF mean values of butyrylcholinesterase activitiesdecreased at 48 (4.09±0.32 nmol min-1 mg-1 of TP) and96 h (3.74±0.20 nmol min-1 mg-1 of TP), whereas inhibitionof acetylcholinesterase was observed at 96 h (47.44±2.78 nmol min-1 mg-1 of TP). In L. mystacinus from RF,an induction of acetylcholinesterase activity was observedat 96 h (36.01±1.09 nmol min-1 mg-1 of TP).Glutathione-S-transferase levels varied between species,being higher in L. mystacinus individuals but lower in S.squalirostris from RF at 48 (272.29 ±11.78 and 71.87±1.70 nmol min-1 mg-1 of TP; respectively) and 96 h(279.25±13.06 and 57.62±4.58 nmol min-1 mg-1 of TP,respectively). Blood cell parameters revealed a lowernumber of mitotic cells (MC: 0.36±0.31%o for S.squalirostris and 0.08±0.05 %o for L. mystacinus)and higher number of eosinophils (E: 3.45±1.75%o for S. squalirostris and 7.64±0.98 %o for L.mystacinus) in individuals from the RF than inindividuals from the RS (MC: 2.55±0.74 %o for S.squalirostris and 1.87±0.72%o for L. mystacinus; andE: 0.13±0.09 for S. squalirostris and 3.20±0.80 for L.mystacinus). Overall, our results demonstrate the existenceof apparent differences in sensitivity betweenspecies in a series of sublethal responses to shorttermexposure in RF after the application of Lambdacyhalothrin.We suggest that the integral use ofbiological endpoints (development and growth) togetherwith biomarkers (cholinesterase, GST, andblood cell parameters) may be a promising integralprocedure for investigating pesticide exposure in wildfrog populations. ","palabras_clave":"Amphibians|Biomarker|Rice fields"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39921,"idioma_id":4,"titulo":"First evidence of the effects of agricultural activities on gonadal form and function in Rhinella fernandezae and Dendropsophus sanborni (Amphibia: Anura) from Entre Ríos Province, Argentina","resumen":"The relationship between male gonadal abnormalities and habitats with different degrees of agricultural activities was quantified in two anuran species, Rhinella fernandezae and Dendropsophus sanborni. The study siteswere selected along a gradient of increasing agricultural land use in south-western Entre Ríos province (Argentina): an agroecosystem, a natural wetland (a non-agricultural site adjacent to monoculture zones), and a natural forest (not associated with agriculture). Rhinella fernandezae and D. sanborni were manually captured from each environmentduring field surveys. A scaled mass index (MI) was evaluated for each animal. Specimens of R. fernandezae from the agroecosystem and the natural wetland site presented poorly developed seminiferous tubules, lower testicular volume,and a lower number of seminiferous tubules, primary spermatogonia, and spermatids than specimens from the naturalforest site. Additionally, we observed fewer primary spermatocytes in the agroecosystem group than in the natural forest group. Individuals of D. sanborni from the agroecosystem and the natural wetland site presented poorly developed tubules, higher proportions of irregularly shaped testes, and a reduced number of primary and secondary spermatogoniacompared with specimens from natural forest sites. Consequently, the affected anurans are likely to have reduced reproductive success. We suggest that agrochemical use may be associated with decreased testicular development and function in both R. fernandezae and D. sanborni occurring in agroecosystems and nearby environments.Buffer zones are needed to prevent contamination, preserve wildlife, and enhance the conservation value of pristine natural forests.","palabras_clave":"AGRICULTURE|ANOMALIES|TESTICULAR HISTOLOGY|GERM CELLS|RHINELLA FERNANDEZAE|DENDROPSOPHUS SANBORNI"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39922,"idioma_id":4,"titulo":"Versatile Action of Picomolar Gradients of Progesterone on Different Sperm Subpopulations","resumen":"High step concentrations of progesterone may stimulate various sperm physiological processes, such as priming and the acrosome reaction. However, approaching the egg, spermatozoa face increasing concentrations of the hormone, as it is secreted by the cumulus cells and then passively diffuses along the cumulus matrix and beyond. In this context, several questions arise: are spermatozoa sensitive to the steroid gradients as they undergo priming and the acrosome reaction? If so, what are the functional gradual concentrations of progesterone? Do spermatozoa in different physiological states respond differentially to steroid gradients? To answer these questions, spermatozoa were confronted with progesterone gradients generated by different hormone concentrations (1 pM to 100 µM). Brief exposure to a 10 pM progesterone gradient stimulated priming for the acrosome reaction in one sperm subpopulation, and simultaneously induced the acrosome reaction in a different sperm subpopulation. This effect was not observed in non-capacitated cells or when progesterone was homogeneously distributed. The results suggest a versatile role of the gradual distribution of very low doses of progesterone, which selectively stimulate the priming and the acrosome reaction in different sperm subpopulations.","palabras_clave":"Acrosomes|Calcium signaling|Ionopheres|Progesterone|Sperm |Reproductive physiology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39923,"idioma_id":5,"titulo":"Algunas consideraciones sobre la sustentabilidad en la agricultura argentina. Herramientas para el cumplimiento de la normativa ambiental","resumen":"Actualmente los países compradores de insumos y mercancías exigen calidad además de valor agregado, lo cual implica adecuar conocimientos y tecnología para obtener productos agrícolas que sean competitivos en el comercio internacional. Dentro de esta tendencia surgieron las Buenas Prácticas Agrícolas (BPA) y las normas sobre Responsabilidad Social, que a través de los sistemas de certificación ayudan a demostrar formalmente el cumplimiento de este ?buen hacer?. En el presente trabajo se pretende analizar y difundir que la implementación de Sistemas de Gestión de la Calidad (SGC), especialmente las Buenas Prácticas Agrícolas (BPA) y las normas sobre Responsabilidad Social, son complementarias para cumplir con lo estipulado en el Derecho Ambiental aplicable al ámbito agrícola argentino. Su importancia radica en que la protección, preservación y la consagración del derecho al ambiente sano antes de la reforma de la Constitución Nacional de 1994 se interpretaba dentro de los derechos implícitos del artículo 33 de la misma. La reforma significó un hito histórico en lo relativo con la evolución del Derecho Ambiental, ya que se incorporó, dentro del capítulo segundo titulado ?Nuevos derechos y garantías?, el artículo 41 donde se estableció el derecho a un ambiente sano, equilibrado, apto para el desarrollo humano y se relaciona de forma directa con otros derechos como a gozar de calidad de vida, al desarrollo, a la salud, a la propiedad, e información, entre otros.","palabras_clave":"sustentabilidad|normas voluntarias"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39924,"idioma_id":4,"titulo":"Placental oxidative status in rural residents environmentally exposed to organophosphates","resumen":"The impact of environmental organophosphate pesticide exposure on the placenta oxidative  status was assessed. Placental samples were collected from women residing in an agricultural area during pesticide pulverization period, non-pulverization period and from control group. Carboxylesterase activity was significantly decreased in pulverization period group. Enzymatic and non-enzymatic defense system, the oxidative stress biomarkers and the nuclear factor erythroid 2-related factor levels showed no differences among groups. However, in the pulverization period group, an inverse association between catalase activity and placental index, a useful metric for estimating placental inefficiency, was found. This result suggests that catalase may serve as a potential placental biomarker of susceptibility to  pesticides. Further studies designed from a gene-environment perspective are needed","palabras_clave":"Placenta|Organofosforados"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39925,"idioma_id":5,"titulo":"Fabricación de materiales con reciclados","resumen":"Las arquitectas Marta Yajnes y Susana Caruso, docentes e investigadoras del CEP ATAE FADU UBA, llevan adelante dentro de la Facultad de Arquitectura, Diseño y Urbanismo de la Universidad de Buenos Aires sendos proyectos de investigación llamados Proyectos SI, acerca de la incorporación de agregados provenientes de Residuos Sólidos Urbanos (RSU) y Residuos de Construcción y Demolición (RCD) en mezclas aptas para uso en productos de construcción y equipamiento.Acerca de las Investigaciones:El hormigón es el material de construcción más empleado en el mundo. Su gran popularidad se debe a sus excelentes características, como durabilidad, resistencia y adaptación a moldes. Al mismo tiempo su uso produce grandes costos medioambientales, entre ellos la enorme cantidad de energía consumida para extracción, acarreo, fabricación y traslado de sus componentes.Los residuos urbanos y de construcción están en constante aumento, contaminando especialmente las áreas suburbanas y amenazando la salud de los habitantes y se hace indispensable un abordaje integral. La necesidad de viviendas que cumplan con los estándares de confort bajando el consumo de energía es urgente, mientras que hay un número elevado de personas dispuestas a producir y a utilizar nuevos productos que cumplan con el paradigma de la sustentabilidad.","palabras_clave":"FABRICACION|SUSTENTABILIDAD|MATERIALES|RESIDUOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39926,"idioma_id":5,"titulo":"Seguridad asociada al uso de antiepilepticos en el Nordeste Argentino: reacciones adversas notificadas al centro regional de farmacovigilancia de la Universidad Nacional del Nordeste","resumen":"El objetivo del estudio fue analizar y describir las reacciones adversas producidas por medicamentos  (RAM), notificadas al Centro Regional de Farmacovigilancia de la Universidad Nacional del  Nordeste (CRF-UNNE) en el periodo 1993-2013. Material y métodos: Estudio observacional descriptivo,  transversal. Se analizaron las notificaciones registradas en la base de datos del CRF-UNNE.  Los fármacos fueron codificados según la Clasificación Anátomo-Terapéutica-Química (ATC-2010)  del Centro Colaborador de la Organización Mundial de la Salud (OMS). La codificación de las RAM  se realizó de acuerdo al Diccionario de Reacciones Adversas de la OMS (WHO Adverse Reaction  Terminology - WHO ART). Fueron clasificadas según su tipo, gravedad y causalidad. Para establecer  la causalidad o imputabilidad, se utilizó el algoritmo de Karch y Lasagna. El análisis estadístico se  realizó mediante el Statistical Package for the Social Sciences (SPSS). Resultados: Sobre 5128 notificaciones  de RAM registradas, 132 fueron causadas por fármacos antiepilépticos (2,6%). Setenta  notificaciones (53%) correspondieron al sexo masculino, con una edad media de 25 años (DS: ±19).  Se observaron 83 reacciones de tipo A (62%), relacionadas con la dosis. De acuerdo a la gravedad  16 (12%) fueron graves, dos fatales; 48 (36%) moderadas y 68 (52%) leves. Según la causalidad 96  (73%) fueron probables, 28 (21%) probadas y 8 (6%) posibles. Los órganos o sistemas afectados,  según la terminología WHO ART, fueron Piel y apéndices 68 (40%), Sistema Nervioso 56 (32%), Digestivo  19 (11%) y Trastornos de la visión 7 (4%). Conclusiones: Se notificaron un elevado porcentaje  de RAM moderadas y leves, en su mayoría de tipo A. Las más graves fueron de tipo B, impredecibles.  Como queda demostrado, los fármacos antiepilépticos no quedan exentos de riesgos de generar  RAM por lo cual su prescripción debería seguir los lineamientos de la terapéutica razonada,  con una evaluación cuidadosa de la relación beneficio\/riesgo para su administración en cada situación,  y en cada paciente","palabras_clave":"ERRORES DE MEDICACION|EPILEPSIA|FARMACOEPIDEMIOLOGIA|USO RACIONAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39927,"idioma_id":4,"titulo":"Capillary Pressure Sensitivity in Modeling CO2 Injection","resumen":"Carbon dioxide (CO2) sequestration consists in injecting and storage the gas into a geologic formation as a means of mitigating the greenhouse effect. Among the storage sites, saline aquifers are very promising because of their large capacity and wide availability. In this work, we perform a sensitivity analysis on the response of a flow simulator to study the impact of capillary pressure in CO2 injection and storage. Capillary pressure is represented as a exponential function of CO2 saturation. The simultaneous flow of CO2 and brine in porous media is based on the well known Black-Oil formulation, applied to two-phase fluid flow. It considers that CO2 may dissolve in the brine but the brine is not allowed to vaporize into the CO2 phase. This formulation uses the PVT data as a simplified thermodynamic model. The numerical solution is obtained applying the public-domain software BOAST, which solves the differential equations by finite differences with the IMPES algorithm. Besides, we build a suitable geological model based on fractal porosity and clay content and taking into account the variation of properties with pore pressure and CO2 saturation. This model also includes embedded mudstone layers of very low permeability that accumulate CO2 but also allow its upward migration. Relative permeability and capillary pressure as functions of CO2 saturation are taken from published data, using the Leverett J-function to scale capillary pressure values. The numerical results show that the fluid simulator is able to represent the CO2 injection and storage. As injection proceeds, part of the injected fluid migrates upwards across the mudstone layers. The simulations are performed using different capillary pressure curves. When capillary pressure is higher, CO2 upward migration is slower and, consequently, different zones of accumulations below the layers and high CO2 saturations levels between layers are obtained. Thus, a precise estimation of the capillary pressure function is needed to perfom realistic long term predictions of the spatial-time CO2 distribution in the underground.","palabras_clave":"CO2 SEQUESTRATION|CAPILLARY PRESSURE|FLUID FLOW SIMULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39928,"idioma_id":4,"titulo":"Self-assembly of flagellin on Au (111) surfaces","resumen":"The adsorption of flagellin monomers from Pseudomonas fluorescens on Au(111) has been studied by Atomic Force Microscopy (AFM), Scanning Tunneling Microscopy (STM), X-ray Photoelectron Spectroscopy (XPS), Surface Plasmon Resonance (SPR), and electrochemical techniques. Results show that flagellin monomers spontaneously self-assemble forming a monolayer thick protein film bounded to the Au surface by the more hydrophobic subunit and exposed to the environment the hydrophilic subunit. The films are conductive and allow allocation of electrochemically active cytochrome C. The self-assembled films could be used as biological platforms to build 3D complex molecular structures on planar metal surfaces  and to functionalize metal nanoparticles.","palabras_clave":"Flagellin|Self-assembly|Protein adsorption|Cytochrome C"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39929,"idioma_id":4,"titulo":"Defeasible logic programming: DeLP-servers, contextual queries, and explanations for answers","resumen":"Argumentation represents a way of reasoning over a knowledge base containing possibly incomplete and\/or inconsistent information, to obtain useful conclusions. As a reasoning mechanism, the way an argumentation reasoning engine reaches these conclusions resembles the cognitive process that humans follow to analyse their beliefs; thus, unlike other computationally reasoning systems, argumentation offers an intellectually friendly alternative to other defeasible reasoning systems. Logic Programming is a computational paradigm that has produced computationally attractive systems with remarkable success in many applications. Merging ideas from both areas, Defeasible Logic Programming offers a computational reasoning system that uses an argumentation engine to obtain answers from a knowledge base represented using a logic programming language extended with defeasible rules. This combination of ideas brings about a computationally effective system together with a human-like reasoning model facilitating its use in applications.","palabras_clave":"argumentation frameworks|defeasible reasoning|defeasible logic programming|Knowledge Representation and Reasoning"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39930,"idioma_id":4,"titulo":"Introduction to structured argumentation","resumen":"In abstract argumentation, each argument is regarded as atomic. There is   no internal structure to an argument. Also, there is no specification   of what is an argument or an attack. They are assumed to be given. This   abstract perspective provides many advantages for studying the nature of   argumentation, but it does not cover all our needs for understanding   argumentation or for building tools for supporting or undertaking   argumentation. If we want a more detailed formalisation of arguments   than is available with abstract argumentation, we can turn to structured   argumentation, which is the topic of this special issue of Argument and   Computation. In structured argumentation, we assume a formal language   for representing knowledge, and specifying how arguments and   counterarguments can be constructed from that knowledge. An argument is   then said to be structured in the sense that normally the premises and   claim of the argument are made explicit, and the relationship between   the premises and claim is formally defined (for instance using logical   entailment). In this introduction, we provide a brief overview of the   approaches covered in this special issue on structured argumentation.","palabras_clave":"formal models of argumentation| logic|argument in logic programming|automated argumentation reasoning system"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39931,"idioma_id":4,"titulo":"On the revision of informant credibility orders","resumen":"In this paper we propose an approach to multi-source belief revision where the trust or credibility assigned to informant agents can be revised. In our proposal, the credibility of each informant represented as a strict partial order among informant agents, will be maintained in a repository called credibility base. Upon arrival of new information concerning the credibility of its peers, an agent will be capable of revising this strict partial order, changing the trust assigned to its  peers accordingly. Our goal is to formalize a set of change operators over the credibility base: expansion, contraction, prioritized, and non-prioritized revision. These operators will provide the capability of dynamically modifying the credibility of informants considering the reliability of the information. This dynamics will reflect a new perception of trust assigned to the informant, or extend the set of informants by admitting the addition of new informant agents.","palabras_clave":"Multi-agent system|Belief revision|Trust|Multi-source belief revision"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39932,"idioma_id":4,"titulo":"An Approach to Argumentative Reasoning Servers with Multiple Preference Criteria","resumen":"Argumentation is a reasoning mechanism of dialectical and non-monotonic nature, with useful properties of computational tractability. In dynamic domains where agents deal with incomplete and contradictory information, an argument  comparison criterion can be used to determine the accepted information; argumentation systems with a single argument comparison criterion have been  widely studied. In some of these approaches the comparison criterion is fixed, while in others a criterion can be selected and replaced in a modular way. In  this work, we introduce an argumentative server that provides recommendations to its client agents and the possibility of indicating under what conditions an argument comparison criterion can be chosen to answer a particular query. To achieve this, we formalize a special type of query which, by using a conditional  expression, allows the server to dynamically choose a criterion. As a result, several properties of these expressions will be studied.","palabras_clave":"Reasoning Server|Argumentation System|Preference Criteria|Criteria Combination"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39933,"idioma_id":4,"titulo":"Protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera","resumen":"Inmunizando a las madres mcon la quimera STx-BLS se observa protección totals de la crias amamantadas por ellas.","palabras_clave":"SUH|vacuna|inmunidad pasiva|toxina shiga"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39934,"idioma_id":4,"titulo":"Wear resistance of nitrided and DLC coated PH stainless steel","resumen":"Precipitation hardening stainless steels are extensively used as a material for plastic injection dies because of their dimensional stability during hardening, impact strength and wear and corrosion resistance. Plasma surface engineering can enhance even more the working life of these components preserving them from wear and corrosion damage by means of surface modification or coatings. In this work PH stainless steel Corrax® was ion nitrided and coated with DLC in a modified PACVD duplex process. DLC films are known not only for their hardness but also for their low friction coefficient, features that improve the wear resistance of steel components. Adhesion tests were performed; wear resistance was tested in a pin on disk machine with different counterparts and in the abrasion ASTM G65 test. Nitrided samples were compared in all tests with DLC only coated samples and the duplex ones (nitriding&nbsp;+&nbsp;coating). The thickness of the nitrided layer was of 14&nbsp;ìm, and the coating, 1.8&nbsp;ìm. The duplex samples had the best abrasive wear resistance; their mass loss was almost negligible and within the error of the instrument. The only coated samples had a very low mass loss compared with the only aged steel, but the coating was detached.        The coated samples presented a low friction coefficient, about 0.03 against alumina and the no wear loss was detected. On the other hand, only the duplex samples presented an acceptable adhesion in the Rockwell C indentation test with 600&nbsp;N and the critical load was 28&nbsp;N in the scratch test.","palabras_clave":"Corrax PH steel|DLC films|Duplex coating|Plasma nitriding|Wear resistance"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39935,"idioma_id":4,"titulo":"Postharvest control of gray mould in apples with lyophilized formulations of Cryptococcus Laurentii: the effect of cold stress in the survival and effectiveness of the yeast","resumen":"The yeast Cryptococcus laurentii (BNM0525) isolated, identified and tested in our laboratory, is an effective Biological Control Agent (BCA) against phytopathogenic molds.  The BCA marketing requires developing a formulation that preserves the viability and biocontrol ability. The objective of this study was to compare the population dynamics and biocontrol capacity of C. laurentii in two physiological conditions: -a) stressed cold (1 °C) and -b) no-stressed (28 °C).  The yeasts were grown in YGM (Yeast Glucose Medium) at 1ºC and 28 °C, then lyophilized using a suitable cryoprotectant with non fat milk.    The growth curve (of formulation lyophilised) and effectiveness against B. cinerea (quantified as Severity Reduction - RS%) were tested in Red Delicious apples wounds, inside cold storage at 4 °C.  RS% of stressed yeast was 79.30% versus 69.12% no-stressed cell.  The stressed cell population reached 5,01x107 CFU\/ml (30 days). That growth curve (stressed) exceed on all times at no-stressed cells curve.  The significant difference between the effectiveness of biocontrol (RS%) could be due to the different population dynamics, namely the major cell concentration of C. laurentii stressed by cold, present throughout the period of the bioassay.  Supported by SeCyT-UNSL 22\/Q541.","palabras_clave":"CRYPTOCOCCUS LAURENTII|COLD STRESS|BIOCONTROL|FREEZE-DRYING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39936,"idioma_id":4,"titulo":"'Effect of temperature on the morphological characteristics of Botrytis cinerea and its correlated with the genetic variability'","resumen":"Objective: Botrytis cinerea is a plant-pathogenic fungus that produces the disease known as grey mould in a wide variety of agriculturally important hosts in many countries. The main objective of the present work was to study the effect of temperature on the morphological characteristics of B. cinerea and its correlated with the genetic variability.  Methods: Six strains from different host collected have been isolated and characterized by several methods as mycelial growth, fungicide resistance, pathogenicity and the effects of the temperature. Also was analyzed by PCR and distinguished by the presence or absence of transposable elements.   Results: Results showed that clear morphological differences exist between strains at the temperature of 4, 12 and 28°C. All strains analyzed molecularly were classified as Group II (transposa-type). Demonstrating a negative correlation between mycelial growth and other characteristics as the fungicide resistance and pathogenicity. Lastly is difficult to establish relationships phenotypic and genotypic between strains of B. cinerea.   Conclusions: The results indicated that the mycelial growth, resistance at fungicide and pathogenicity are independent of the characteristics molecular, however are dependent of a factor such as temperature.","palabras_clave":"BOTRYTIS CINEREA|TRANSPOSABLE ELEMENTS|TEMPERATURE|PATHOGENICITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39937,"idioma_id":4,"titulo":"Hindlimb myology of the monk parakeet (Aves, Psittaciformes)","resumen":"We studied the hindlimb myology of the monk parakeet (Myiopsitta monachus). Like all parrots, it has zygodactyl feet enabling perching, climbing, hanging, moving easily among trees, and handling food. Muscles were described and weighed, and physiological cross-sectional area (PCSA) of four flexors and one extensor was calculated. In comparison to other muscles, the M. tibialis cranialis and the M. fibularis brevis show increased development and high PCSA values, and therefore, large potential force production. Also, a large proportion of muscle mass was involved in flexing the digits. We hypothesize that these muscle traits are associated with the arboreal locomotion and food manipulation habits. In the monk parakeet, the M. extensor digitorum longus sends a branch to the hallux, and the connection between the M. flexor digitorum longus and the M. flexor hallucis longus is type I (Gadow´s classification). We reaffirm the presence of the M. ambiens as a plesiomorphic condition that disappears in most members of the order. Among Psittaciformes, the M. fibularis brevis is stronger and the M. fibularis weaker in arboreal species than in basal terrestrial ones (e.g., Strigops).","palabras_clave":"MYIOPSITTA MONACHUS|ZYGODACTYL FEET|NEOTROPICAL PARROTS|MUSCLE|ARBOREAL LOCOMOTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39938,"idioma_id":4,"titulo":"Size effects in bimagnetic CoO\/CoFe2O4 core\/shell nanoparticles","resumen":"The control of the size of bimagnetic nanoparticles represents an important step toward the study of fundamental properties and the design of new nanostructured magnetic materials. We report the synthesis and the structural and magnetic characterization of bimagnetic CoO\/CoFe2O4 core\/shell nanoparticles. The material was fabricated by a seed-mediated growth high-temperature decomposition method with sizes in the range of 5?11 nm. We show that the core\/shell morphology favours the crystallinity of the shell phase, and the reduction of the particle size leads to a remarkable increase of the magnetic hardening. When the size is reduced, the coercive field at 5 K increases from 21.5 kOe to 30.8 kOe, while the blocking temperature decreases from 388 K to 167 K. The size effects on the magnetic behaviour are described through a phenomenological model for strongly ferri-\/antiferromagnetic coupled phases.","palabras_clave":"BIMAGNETIC NANOPARTICLES|MAGNETIC ANISOTROPY|INTERFACE EXCHANGE COUPLING|COBALT FERRITE|NANOMAGNETISM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39939,"idioma_id":5,"titulo":"Un análisis sobre la inseguridad en la  prensa: representaciones discursivas sobre  el delito en un caso periodístico","resumen":"En julio de 2010, en la provincia de Buenos Aires, Carolina Piparo, una joven embarazada, es atacada por dos asaltantes tras retirar dinero de un banco y, como consecuencia de la agresión, su bebé muere al poco tiempo de nacer. El caso adquiere relevancia en los medios y tiene repercusiones políticas, constituyéndose como caso emblemático de ?inseguridad?, temática central en la agenda periodística y política en Argentina. Nuestro trabajo parte del interés por observar cómo los medios de comunicación construyen en su discurso los ?hechos de inseguridad?. El objetivo es analizar, desde el marco teórico del Análisis Crítico del Discurso (ACD), las representaciones discursivas que los principales diarios argentinos construyen sobre el ?caso Piparo? y los actores involucrados en él: las víctimas, los agresores, las instituciones bancarias, los investigadores y los funcionarios políticos. El análisis muestra cómo (de forma diferenciada de acuerdo al diario) las noticias construyen a las víctimas como figura central, apelando en ocasiones a una dimensión emotiva y moral, en oposición a los agresores, representados como salvajes e inhumanos. El caso, descrito como   ?brutal? y ?conmocionante?, se utiliza para la (re)producción de un ?guión de la inseguridad?, que, al cuestionar a las instituciones (los bancos, la policía o el gobierno) y presentar un panorama atemorizante, fundamenta los reclamos de mayor seguridad.","palabras_clave":"DIARIOS|DELITO|INSEGURIDAD|ACD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39940,"idioma_id":4,"titulo":"S100B protein activates a RAGE-dependent autocrine loop in astrocytes:  Implications for its role in the propagation of reactive gliosis","resumen":"Extracellular S100B dramatically increases after brain injury.  While low S100B levels are neuroprotective, micromolar  S100B levels have shown in vitro to activate microglia and  facilitate neuronal death. In astrocytes, S100B exposure  activates nuclear factor kappa B (NF-jB) and induces proinflammatory  mediators. On microglia and neurons S100B  effects are essentially mediated by receptor for advanced  glycation end products (RAGE)\/NF-jB, but it is not clear if  these intracellular cascades are activated by different S100B  levels in astrocytes and whether increased extracellular S100B  is sufficient to induce reactive gliosis. A better understanding of  these pathways is essential for developing successful strategies  to preserve the beneficial S100B effects after brain injury.  Here, we show that microglia-depleted cultured astrocytes  exposed to S100B mimicked several features of reactive  gliosis by activating RAGE\/Rac-1-Cdc42, RAGE\/Erk-Akt or  RAGE\/NF-jB-dependent pathways. S100B effects include  RAGE\/Rac1-Cdc42-dependent astroglial hypertrophy and  facilitation of migration as well as increased mitosis. S100B  exposure improved the astrocytic survival to oxidative stress,  an effect that requires Erk\/Akt. S100B also activates NF-jB in  a dose-dependent manner; increases RAGE proximal promoter  transcriptional activity and augmented endogenous  RAGE expression. S100B-exposed astrocytes showed a proinflammatory  phenotype with expression of Toll-like receptor 2  (TLR 2), inducible nitric oxide synthase (iNOS) and interleukin  1-beta (IL-1b), and facilitated neuronal death induced by  oxygen-glucose deprivation. In vivo, intracerebral infusion of  S100B was enough to induce an astroglial reactive phenotype.  Together, these findings demonstrate that extracellular S100B  in the micromolar level activates different RAGE-dependent  pathways that turn astrocytes into a pro-inflammatory and  neurodegenerative phenotype.  Keywords: DAMP, inflammation, reactive gliosis.  J. Neurochem. (2014) 131, 190?205.","palabras_clave":"DAMP|inflammation|reactive gliosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39941,"idioma_id":4,"titulo":"Synthesis of magnesium aluminate spinel by periclase and alumina chlorination","resumen":"A pyrometallurgical route for the synthesis of magnesium aluminate spinel by thermal treatment of amechanical mixture containing 29 wt% MgO (periclase) and 71 wt% Al2O3 (alumina) in chlorineatmosphere was developed and the results were compared with those obtained by calcining the samemixture of oxides in air atmosphere. Isothermal and non-isothermal assays were performed in anexperimental piece of equipment adapted to work in corrosive atmospheres. Both reagents and productswere analyzed by differential thermal analysis (DTA), X-ray diffraction (XRD) and X-rayfluorescence(XRF). Thermal treatment in Cl2 atmosphere of the MgO?Al2O3 mixture produces magnesium aluminatespinel at 700 C, while in air, magnesium spinel is generated at 930 C. The synthesis reaction ofmagnesium aluminate spinel was complete at 800 C.","palabras_clave":"MAGNESIUM ALUMINATE SPINEL|CHEMICAL SYNTHESIS|THERMOGRAVIMETRIC ANALYSIS|X-RAYDIFFRACTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39942,"idioma_id":4,"titulo":"Argentine Beef Demand and Household Choices of Retail Channels","resumen":"Household choices of outlet retail channels in beef purchases depend on several characteristics related to the quality of the product, convenience and ease of purchase, and economic factors such as price, income and payment methods. The aim of this paper is to study the influence of demographic and socio-economic attributes in the choice made by argentine   consumers using a Multinominal Logit Model. The results show that the total number of purchases, the type of household, payment methods, and gender and schooling years of household head are the most relevant variables in the sample.","palabras_clave":"Beef|Household consumption|Multinomial Logit|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39943,"idioma_id":5,"titulo":"Descolonizar la descolonización mediante la didáctica integrada de historia y lengua","resumen":"El artículo reflexiona en torno a los conceptos de nación y cultura y suimpacto en la didáctica de la historia y de las lenguas extranjeras. Construimosluego un marco conceptual mixto a partir del Enfoque Integrado de Contenidos yLengua y la competencia comunicativa intercultural. Tras la reflexión teórica,presentamos una propuesta didáctica para estudiantes de español lenguaextranjera sobre el encuentro entre San Martín y Bolívar. A partir de esta unidadanhelamos ?descolonizar? el tratamiento de la descolonización así como sugerirlineamientos para nuevas propuestas de enseñanza.","palabras_clave":"Descolonización|Español L2|Entrevista de Guayaquil|Enfoque Integrado de Contenidos y Lengua|Competencia comunicativa intercultural"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39944,"idioma_id":4,"titulo":"Activity of Order n in Continuous Systems","resumen":"In this work we generalize the concept of activity of continuous time signals. We de&#64257;ne the activity of order n of a signal and show that it allows to estimate the number of sections of polynomials up to order n which are needed to represent that signal with certain accuracy. Then, we apply this concept to obtain a lower bound for the number of steps performed by quantization?based integration algorithms in the simulation of ordinary di&#64256;erential equations. We perform an exhaustive analysis over two examples, computing the activity of order n and comparing it with the number of steps performed by di&#64256;erent integration methods. This analysis corroborates the theoretical predictions and also allows to measure the suitability of the di&#64256;erent algorithms depending on how close they perform in comparison with the theoretical lower bound.","palabras_clave":"DEVS|NUMERICAL METHODS|CONTINUOUS SYSTEMS|SIMULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39945,"idioma_id":4,"titulo":"Biological activity of extracts from leaves of Colliguaja integerrima (Hook.) gill. (Euphorbiaceae).","resumen":"Colliguaja integerrima (Euphorbiaceae) was used by Tehuelches-Mapuches of Patagonia to treat corns, warts, toothache. This study aimed to evaluate the biological in vitro activity of extracts obtained from leaves of C. integerrima related to their traditional uses.Leaves were extracted with aqueous methanol (Et). Et was partitioned with petroleum ether, chloroform, ethyl ether, ethyl acetate, water (E1-E5). They were assayed for antimicrobial activity by agar-well diffusion and for antioxidant activity by DPPH method. The inhibition of radicular growing was assayed with Et, E4 and E5.E4 inhibited the development of standard strains of Staphylococcus aureus (MIC = 0.50 mg\/mL); Pseudomonas aeruginosa and Escherichia coli (MIC of 0.25 mg\/mL in both cases). The antioxidant activity was important for all the extracts (SC50 of E4 = 5.75 µg\/mL).Et and E5 (1 %) inhibited root length in a similar way as vinblastin sulphate 0.02 %; E4 showed higher activity.Consequently, the chemical composition of this extract, the antibacterial and antioxidant activities demonstrated are evidences that could justify the traditional use in toothache which is extensively related with infection, inflammatory processes and tissue damage induced by ROS. Furthermore, citotoxic activity and antioxidant properties are related to traditional uses for corns and warts.","palabras_clave":"ANTIMICROBIAL|ANTIOXIDANT|COLLIGUAJA|INTEGERRIMA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39946,"idioma_id":4,"titulo":"Physiological aspects of fruit ripening: the mitochondrial connection","resumen":"Fruit ripening is a genetically programmed process which leads to an assortment of physiological and metabolic changes that irreversibly alter its characteristics. Depending on the species, fruit maturation can be either climacteric or non-climacteric. In both cases there is a metabolic shift from normal development conditions towards the fully mature state, but climacteric fruit is characterized by a sharp increase in respiration. In non-climacteric fruit, that generally do not display this feature, respiration changes can be affected by processes related to postharvest storage. This review describes some of the many ways in which mitochondrial metabolism is implicated in this crucial reproductive stage, such as the connection between ethylene production and respiration rate, the involvement of alternative oxidase (AOX) and plant uncoupling mitochondrial protein (PUMP) during the ripening and the common alterations of this organelle in fruits affected by different stress conditions","palabras_clave":"FRUIT| RIPENING|RESPITARION|CLIMATERIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39947,"idioma_id":4,"titulo":"A broad spectrum of genomic changes in ext1\/ext2-cdg patients with a severe phenotype of multiple osteocondromatosis in Latin American countries.","resumen":"Multiple osteochondromatosis (MO), or EXT1\/EXT2-CDG, is an autosomal dominant O-linked glycosylation disorder characterized by the formation of multiple cartilage-capped tumors (osteochondromas). In contrast, solitary osteochondroma (SO) is a non-hereditary condition. EXT1 and EXT2, are tumor suppressor genes that encode glycosyltransferases involved in heparan sulfate elongation. We present the clinical and molecular analysis of 33 unrelated Latin American patients (27 MO and 6 SO). Sixty-three percent of all MO cases presented severe phenotype and two malignant transformations to chondrosarcoma (7%). We found the mutant allele in 78% of MO patients. Ten mutations were novel. The disease-causing mutations remained unknown in 22% of the MO patients and in all SO patients. No second mutational hit was detected in the DNA of the secondary chondrosarcoma from a patient who carried a nonsense EXT1 mutation. Neither EXT1 nor EXT2 protein could be detected in this sample. This is the first Latin American research program on EXT1\/EXT2-CDG.","palabras_clave":"glycosilation|CDG|skeletal dysplasia|EXT1\/EXT2-CDG"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39948,"idioma_id":4,"titulo":"Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment","resumen":"Abnormal glycosylation is a typical hallmark of the transition from healthy to neoplastic tissues. Although the importance of glycans and glycan-binding proteins in cancer-related processes such as tumor cell adhesion, migration, metastasis and immune escape has been largely appreciated, our awareness of the impact of lectin-glycan recognition in tumor vascularization is relatively new. Regulated glycosylation can influence vascular biology by controlling trafficking, endocytosis and signaling of endothelial cell (EC) receptors including vascular endothelial growth factor receptors, platelet EC adhesion molecule, Notch and integrins. In addition, glycans may control angiogenesis by regulating migration of endothelial tip cells and influencing EC survival and vascular permeability. Recent evidence indicated that changes in the EC surface glycome may also serve â??on-and-offâ?switches that control galectin binding to signaling receptors by displaying or masking-specific glycan epitopes. These glycosylation-dependent lectin-receptor interactions can link tumor hypoxia to EC signaling and control tumor sensitivity to anti-angiogenic treatment.","palabras_clave":"ANGIOGENESIS|GALECTIN-1|GALECTINS|GLYCOSYLATION|HYPOXIA|IMMUNOTHERAPY|LECTINS|VASCULATURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39949,"idioma_id":4,"titulo":"Abnormal mitochondrial fusion-fission balance contributes to the progression of experimental sepsis","resumen":"Sepsis-associated multiple organ failure is a major cause of mortality characterized by a massive increase of reactive oxygen and nitrogen  species (ROS\/RNS) and mitochondrial dysfunction. Despite intensive research, determining events in the progression or reversal of  the disease are incompletely understood. Herein, we studied two prototype sepsis models: endotoxemia and cecal ligation and puncture  (CLP) ? which showed very di&#64256; erent lethality rates (2.5% and 67%, respectively) ? , evaluated iNOS, ROS and respiratory chain activity,  and investigated mitochondrial biogenesis and dynamics, as possible processes involved in sepsis outcome. Endotoxemia and CLP showed  di&#64256; erent iNOS, ROS\/RNS, and complex activities time-courses. Moreover, these alterations reverted after 24-h endotoxemia but not after  CLP. Mitochondrial biogenesis was not elicited during the &#64257; rst 24 h in either model but instead, 50% mtDNA depletion was observed.  Mitochondrial fusion and &#64257; ssion were evaluated using real-time PCR of mitofusin-2 (Mfn2), dynamin-related protein-1 (Drp1), and using  electron microscopy. During endotoxemia, we observed a decrease of Mfn2-mRNA levels at 4 ? 6 h, and an increase of mitochondrial  fragmentation at 6 h. These parameters reverted at 24 h. In contrast, CLP showed not only decreased Mfn2-mRNA levels at 12 ? 18 h but  also increased Drp1-mRNA levels at 4 h, and enhanced and sustained mitochondrial fragmentation. The  in vivo  pretreatment with mdivi-1  (Drp1 inhibitor) signi&#64257; cantly attenuated mitochondrial dysfunction and apoptosis in CLP. Therefore, abnormal fusion-to-&#64257; ssion balance,  probably evoked by ROS\/RNS secondary to iNOS induction, contributes to the progression of sepsis. Pharmacological targeting of Drp1  may be a potential novel therapeutic tool for sepsis.","palabras_clave":"iNOS| lipopolysaccharide|mitochondria|nitric oxide"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39950,"idioma_id":4,"titulo":"Effect of fasting in house sparrows digestive system: Histological study of small intestine","resumen":"The metabolic response of birds and mammals to fasting has been studied and characterized by three phases reflecting metabolic and physiological adjustments. An effective way to minimize energy expenditure during food scarcity is organ mass decrease. The digestive system is metabolically expensive to maintain, so small intestine and liver are the most affected organs. We evaluated the phase III starvation effects on organ mass and histological parameters on house sparrows, a small no migrant bird. In short time (34 hs) we observed a disproportionately large reduction of digestive organ mass compared with the decline in body mass and nonalimentary tissues. However, intestinal mass was more reduced than intestinal length and nominal surface area. Regarding histological parameters, a reduction on intestinal mucosal layer also resulted in a shortening of villus (length and thickness) and crypt depth.  Moreover, enterocytes morphology also changed from cylindrical to cube suggesting that the surface exposed to lumen was conserved. This observation and the fact that nominal surface area\/body mass remains constant in both treatments could be indicating an adaptive response  to the moment of refeeding. In spite of the reduction of several histological parameters suggesting that starving produces the atrophy of small intestine, globet cells were conserved after fasting indicating a protective tendency.","palabras_clave":"starvation|gastrointestinal tract|histological parameters|no migrant birds"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39951,"idioma_id":4,"titulo":"Hydrogen production from ethanol with low carbon monoxide generation in a one-pot reaction with iron oxides as catalysts","resumen":"Bulk &#947;-Fe2O3 (maghemite) and Fe3O4 (magnetite) were synthesized with Fe(III) hydroxyacetate as an intermediate during the preparation step. The fresh and used catalysts were characterized by X-ray diffraction, N2 adsorption at 77 K, Mössbauer spectroscopy at 298 K, diffuse-reflectance spectroscopy, and thermogravimetric analysis. The solids were used as catalysts in the ethanol hydrotreatment within the range of 673-758 K. The catalysts showed a satisfactory selectivity for H2 and an especially low CO production. These activities and selectivities were analyzed in conjunction with the structural properties of the oxides. Magnetite seemed to be a more appropriate catalyst than maghemite since the latter was converted into magnetite at reaction temperatures higher than 713 K because of the reducing atmosphere.","palabras_clave":"Hydrogen production with low CO content|Ethanol hydrotreatment|Magnetite catalyst"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39952,"idioma_id":5,"titulo":"Construyendo nuevas miradas pedagógicas en  pos de la accesibilidad académica en la  Universidad","resumen":"Durante el primer cuatrimestre del año 2012 la asignatura Patrimonio Natural Regional de la carrera Tecnicatura de Empresas de Servicios Turísticos ? Facultad de Turismo ? Universidad Nacional del Comahue; contó con la presencia de un estudiante en situación de discapacidad (motora).   A partir de la iniciativa de los docentes de la asignatura, se solicita apoyo institucional y se toma contacto con la Comisión Universitaria sobre Accesibilidad al Medio Físico y Social, para consensuar estrategias a implementar en la evaluación parcial del alumno en situación de discapacidad en relación al resto del curso.   Este trabajo tiene por objetivos: reflexionar acerca de la evaluación parcial con estudiantes en situación de discapacidad y proponer cambios en la evaluación parcial de la asignatura Patrimonio Natural Regional en relación a estudiantes en situación de discapacidad motora. La metodología usada por el equipo de cátedra fue de un estudio de diseño para las asignaturas del área de concurso Recursos Naturales, contextualizado para el estudiante en situación de   discapacidad con el asesoramiento de la comisión sobre accesibilidad y   también de la comunicación con el alumno.   Algunas conclusiones a las que se arribó tienen relación con los ejes 1.   Necesidad de evaluaciones con nuevas estrategias pedagógicas contextuales   particulares; 2.Necesidad de un acompañamiento institucional ante la presencia de estudiantes en situación de discapacidad en las aulas.","palabras_clave":"IINCLUSION EDUCATIVA|EVALUACION|SITUACION DE DISCAPACIDAD|UNIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39953,"idioma_id":4,"titulo":"A Possibilistic Defeasible Logic Programming Approach to Argumentation-Based Decision Making","resumen":"The development of symbolic approaches to decision-making has become an ever-growing research line in artificial intelligence; argumentation has contributed to that with its unique strengths. Following this trend, this article proposes a general-purpose decision framework based on argumentation. Given a set of alternatives posed to the decision-maker, the framework represents the agent´s preferences and knowledge by an epistemic component developed using possibilistic defeasible logic programming. The reasons by which a particular alternative is deemed better than another are explicitly considered in the argumentation process involved in warranting information from the epistemic component. The information warranted by the dialectical process is then used in decision rules that implement the agent´s general decision-making policy. Essentially, decision rules establish patterns of behaviour of the agent specifying under which conditions a set of alternatives will be considered acceptable; moreover, a methodology for programming the agent´s epistemic component is defined. It is demonstrated that programming the agent´s epistemic component following this methodology exhibits some interesting properties with respect to the selected alternatives; also, when all the relevant information regarding the agent´s preferences is specified, its choice behaviour coincides with respect to the optimum preference derived from a rational preference relation.","palabras_clave":"NON-MONOTONIC REASONING |ARGUMENTATION |POSSIBILISTIC DEFEASIBLE LOGIC PROGRAMMING |DECISION MAKING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39954,"idioma_id":4,"titulo":"Mother dough in bread making","resumen":"      The objective of this work was the preparation of mother dough and to  study the effect produced on bread, besides to look for the kind of bread that  best reflects the effect of using sourdough. pH and acidity were measured to sourdough  without replenish during 7 days at 5oC and to sourdough with replenishment  every 24 hours, during 27 days at 5oC. Breads were made applying both the  French and the pan bread methods. Experts scored the external and internal characteristics  of breads. When the sourdough is maintained at 5oC and replenished every 24 hours,  its stabilization is achieved at the day 10 with a pH of 4.40 and an acidity of  6.5 mass meq\/100 g. By other hand, when the sourdough is maintained at 5oC but  is not replenished every 24 hours, pH and acidity are constant up to the day 3  and then a very important change is produced. The addition of 10% of mother  dough improves quality of crumb structure and flavor in the French type bread  while there is not an improved quality of the pan bread. Therefore, the French  type bread is the kind of bread that best reflects the effect of using mother  dough.  ","palabras_clave":"MOTHER DOUGH|WHEAT FLOUR|BREAD|BAIKING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39956,"idioma_id":4,"titulo":"Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII","resumen":"The transmembrane isoforms of carbonic anhydrase (hCA IX and XII) have been shown to be linked to carcinogenesis and their inhibition to arrest primary tumor and metastases growth. In this paper, we present a new class of Cglycosides incorporating the methoxyaryl moiety, that was designed to selectively target and inhibit the extracellular domains of the cancer-relevant CA isozymes. The glycosides have been prepared by aldol reaction of glycosyl ketones with the appropriate aromatic aldehydes. We also present the inhibition profile of our new glycomimetics, against four isozymes of carbonic anhydrase comprising hCAs I and II (cytosolic, ubiquitous isozymes) and hCAs IX and XII(tumor associated isozymes). In this study, per-O-acetylated glycoside 4, 6 and deprotected compounds 7,9,10 and 12 were identified as potent and highly selective inhibitors of hCA IX and XII. These results confirm that attaching carbohydrate moieties to CA methoxyaryl pharmacophore improves and enhances its inhibitory activity. These CA inhibitors have developmental potential to selectively target cancer cells, leading to cell death.","palabras_clave":"Glycomimetics|Enzyme inhibitors|Cancer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39957,"idioma_id":4,"titulo":"Topoisomerase I inhibitor, camptothecin, induces apoptogenic signaling in human embryonic stem cells","resumen":"Embryonic stem cells (ESCs) need to maintain their genomic integrity in   response to DNA damage to safeguard the integrity of the organism. DNA   double strand breaks (DSBs) are one of the most lethal forms of DNA   damage and, if not repaired correctly, they can lead to cell death,   genomic instability and cancer. How human ESCs (hESCs) maintain genomic   integrity in response to agents that cause DSBs is relatively unclear.   In the present study we aim to determine the hESC response to the DSB   inducing agent camptothecin (CPT). We find that hESCs are hypersensitive   to CPT, as evidenced by high levels of apoptosis. CPT treatment leads   to DNA-damage sensor kinase (ATM and DNA-PKcs) phosphorylation on serine   1981 and serine 2056, respectively. Activation of ATM and DNA-PKcs was   followed by histone H2AX phosphorylation on Ser 139, a sensitive   reporter of DNA damage. Nuclear accumulation and ATM-dependent   phosphorylation of p53 on serine 15 were also observed. Remarkably, hESC   viability was further decreased when ATM or DNA-PKcs kinase activity   was impaired by the use of specific inhibitors. The hypersensitivity to   CPT treatment was markedly reduced by blocking p53 translocation to   mitochondria with pifithrin-&#956;. Importantly, programmed cell death was   achieved in the absence of the cyclin dependent kinase inhibitor,   p21(Waf1), a bona fide p53 target gene. Conversely, differentiated hESCs   were no longer highly sensitive to CPT. This attenuated apoptotic   response was accompanied by changes in cell cycle profile and by the   presence of p21(Waf1). The results presented here suggest that p53 has a   key involvement in preventing the propagation of damaged hESCs when   genome is threatened. As a whole, our findings support the concept that   the phenomenon of apoptosis is a prominent player in normal embryonic   development.","palabras_clave":"APOPTOSIS|CELULAS MADRE PLURIPOTENTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39958,"idioma_id":5,"titulo":"p19INK4d is involved in the cellular senescence mechanism contributing to heterochromatin formation","resumen":"Background: During evolution, organisms with renewable tissues have developed mechanisms to prevent tumorigenesis, including cellular senescence and apoptosis. Cellular senescence is characterized by a permanent cell cycle arrest triggered by both endogenous and exogenous stress. The p19INK4d, a member of the INK4 family of cyclin-dependent kinase inhibitors, plays an important role on cell cycle regulation and in the cellular DNA damage response. We hypothesize that p19INK4d is a potential factor involved in the onset and\/or maintenance of the senescent state.   Methods: Senescence was con&#64257;rmed by measuring the cell cycle arrest and the senescence-associated &#946;-galactosidase activity. Changes in p19INK4d expression and localization during senescence were determined by western blot and immuno&#64258;uorescence assays. Chromatin condensation was measured by microccocal nuclease digestion and histone salt extraction.  Results: The data presented here show for the first time that p19INK4d expression is up-regulated by different types of senescence. Changes in senescence-associated hallmarks were driven by modulation of p19 expression indicating a direct link between p19INK4d induction and the establishment of cellular senescence. Following a senescence stimulus, p19INK4d translocates to the nucleus and tightly associates with chromatin. Moreover, reduced levels of p19INK4d impair senescence-related global genomic heterochromatinization. Analysis of p19INK4d mRNA and protein levels in tissues from differently aged mice revealed an up-regulation of p19INK4d that correlates with age.   Conclusion: We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction.  General significance: This study provides novel insights into the dynamics process of cellular senescence, a central tumor suppressive mechanism.","palabras_clave":"SENESCENCIA|MANTENIMIENTO INTEGRIDAD GENOMA|HETEROCROMATINA|ENVEJECIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39959,"idioma_id":4,"titulo":"Land use and land cover effects on regional biodiversity distribution in a subtropical dry forest: a hierarchical integrative multi-taxa study","resumen":"Latin American subtropical dry ecosystems have experienced significant human impact for more than a century, mainly in the form of extensive livestock grazing, forest products extraction and agriculture expansion. We assessed the regional-scale effect of land use and land cover (LULC) on patterns of richness distribution of trees, birds, amphibians and mammals in the Northern Argentine Dry Chaco (NADC) over c. 19 million hectares. Using species distribution models in a hierarchical framework, we modeled the distributions of 138 species. First, we trained the models for the entire Argentinean Chaco with climatic and topographic variables. Second, we modeled the same species for the NADC including the biophysical variables identified as relevant in the first step plus four LULC-related variables: woody biomass, distance to crops, density of livestock-based rural settlements (puestos) and vegetation cover. Third, we constructed species richness maps by adding the models of individual species and considering two situations, with and without LULC variables. Four, richness maps were used for assessing differences when LULC variables are added, and for determining the main drivers of current patterns of species richness. We found a marked decrease of richness species of the four groups as consequence of inclusion of LULC variables in distribution models. The main factors associated with current richness distribution patterns (both negatively) were woody biomass and density of livestock puestos. Species richness in present-day Semiarid Chaco landscapes is strongly affected by LULC patterns, even in areas not transformed to agriculture. Regional-scale biodiversity planning should consider open habitats such as grasslands and savannas in addition to woodlands.","palabras_clave":"Amphibians|Birds|Chaco|Hierarchical species distribution modeling|Mammals"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39960,"idioma_id":5,"titulo":"El discurso del docente en clase de lengua y literatura: entre la facilitación y la portación de saberes","resumen":"En este artículo analizamos tres clases de lengua y  literatura de igual duración, dictadas en el nivel secundario en tres  provincias argentinas. Nuestros objetivos son dos: por un lado, estudiar en qué  medida, de qué forma y en relación con qué contextos los docentes de lengua y  literatura actúan como facilitadores del aprendizaje o como portadores de  saberes, y por otro, emplear una metodología de investigación que sirva a los  docentes para analizar sus prácticas en los contextos en los que se  desarrollan. Nuestro marco teórico es la Lingüística Sistémico Funcional y nos  valemos particularmente de la metafunción intepersonal y de la teoría de la  valoración. Los resultados del análisis revelan muy diferentes opciones de  negociación del tenor de la situación, plasmadas a nivel léxico-gramatical en  distintos modos verbales y expresiones de las actitudes. Estas diferencias  resultan estrechamente asociadas a los contextos de situación en los que las  clases se desarrollaron. ","palabras_clave":"ANÁLISIS DEL DISCURSO|GÉNEROS AÚLICOS|LENGUA Y LITERATURA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39961,"idioma_id":4,"titulo":"Oviposition Site Preference for Natural Breeding Sites in Drosophila melanogaster (Diptera: Drosophilidae) Populations from Argentina","resumen":"                Maternal decisions, like the choice of  a site for laying eggs, have important ecological and evolutionary implications.  In the present study, we investigated variation, both within- and between-  populations in oviposition site preference in a collection of isofemale lines  derived from three Drosophila melanogaster Meigen natural populations of  western Argentina. In the oviposition preference assay we employed two  resources that fruit flies utilize as egg laying sites in nature. Results  revealed, i) the distribution of eggs across the two alternative resources  offered to the flies deviated from randomness when flies were given the chance  to choose between grape and orange, ii) oviposition site preference (OSP)  varied within and between populations, and iii) a substantial proportion of OSP  variation has a genetic basis as suggested by the significant contribution of  variation among lines to total trait variance. Our survey represents an initial  step in understanding patterns of natural variation in oviposition preferences  for natural resources in D. melanogaster.   ","palabras_clave":"oviposition site preference |phenotypic variation |genetic variation |natural breeding resources"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39962,"idioma_id":4,"titulo":"Ocular delivery of Flurbiprofen based  on Eudragit E-flurbiprofen complex dispersed in aqueous solution - preparation, characterization, in vitro corneal penetration and ocular irritation","resumen":"A novel ophthalmic formulation based on the ionic complexation between Eudragit E 100 (EU) and  flurbiprofen (FB) is proposed. The selected complex composition, named EU-FBH 50 Cl 50  had the  basic groups of EU completely neutralized with equal molar amounts of FB and HCl. This complex,   obtained in the solid state, exhibited a high aqueous compatibility producing a colloidal dispersion  with a high positive electrokinetic potential, in which more than 99% of FB was ionically condensed  with EU. In bicompartimental Franz cells, FB diffusion from the complex was very slow. However,  dispersion in NaCl 0.9% increased the FB release through an ionic exchange, providing an optimal  constant rate of delivery.  Corneal FB permeation from 0.1% EU-FBH 50 -Cl 50  dispersed in 0.9% NaCl   solution was substantially more effective compared to FB 0.1% solution, EU-FBH 50 -Cl 50 (Dex) or  Tolerane � (a marketed formulation). This complex formulation was shown to be innocuous for rabbit   ocular tissues, since no irritant effects were evidenced.","palabras_clave":"Flurbiprofen, |Eudragit, complex, |ophthalmic solution."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39963,"idioma_id":4,"titulo":"Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with Fenoprofen in comparison to the parent drug. Promising insights in the treatment of chronic inflammatory diseases?","resumen":"Analgesic and ulcerogenic properties have been studied for the copper(II) coordination complex of the nonsteroidal antiinflammatory  drug Fenoprofen and the biologically active molecule imidazole with the formula [Cu(fen)2(im)2] (where Cu:  copper(II) ion; fen: fenoprofenate anion from Fenoprofen acidic form; im: imidazole). In all assays, a therapeutic dose of 28mg\/kg  was tested for [Cu(fen)2(im)2] and a dose of 21 mg\/kg was employed for Fenoprofen calcium salt, administered by oral gavage in  female mice in order to compare the therapeutic properties of the new entity and the commercial parent drug. The acetic acidinduced  writhing test was employed in vivo in mice for the study of visceral pain. Results revealed that the percentage of inhibition  in writhing and stretching was 78.9% and 46.2% for the [Cu(fen)2(im)2] complex and Fenoprofen calcium salt, respectively. This  result indicates that the complex could bemore effective in diminishing visceral pain than the uncomplexed drug.The formalin test  was evaluated in mice in order to study the impact of the drugs studied over nociceptive and inflammatory pain. Results revealed  that the complex is amore potent analgesic on inflammatory pain than the parent drug, Fenoprofen calciumsalt.Ulcerogenic effects  were evaluated using a model of gastric lesions induced by hypothermic-restraint stress. Fenoprofen calcium salt caused an ulcer  index of about 79mm2 while the one caused by [Cu(fen)2(im)2] was found to be 22mm2. This study revealed that the complex  diminished the development of gastric mucosal ulcers in comparison to the uncomplexed parent drug. Possible mechanisms of  action related to both therapeutic properties studied have been discussed. The presence of copper(II) ion in the complex moiety  may become crucial for the enhanced therapeutic properties of [Cu(fen)2(im)2] in comparison to uncomplexed Fenoprofen.","palabras_clave":"ANALGESIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39964,"idioma_id":5,"titulo":"La experiencia de la posibilidad","resumen":"Surge la creación.Una revolución cognitiva se pone en marcha junto al papel de los afectos y dela energía circulante. La experiencia de la posibilidad de encontrarse con undesafío realizado, la percepción del logro, el recuerdo de las discusiones, lascharlas de los espacios de colaboración, de la merienda compartida, de la seriede toma de decisiones que se pusieron en marcha y que permitieron laconstrucción del objeto, conforman el entramado que permite que cada sábado,los chicos, los jóvenes, los adultos vuelvan y la escuela se tiña de potencia,creación y deseo, reciclado, reinventado, resignificado","palabras_clave":"EDUCACION NO FORMAL|ENSEÑANZA|APRENDIZAJE|CREATIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39965,"idioma_id":4,"titulo":"Copolymers Based on Epoxidized Soy Bean Oil and Diglycidyl Ether of Bisphenol A: Relation Between Morphology and Fracture Behavior","resumen":"Epoxidized soybean oil (ESO) was proved to be a good  alternative to partially replace a synthetic commercial  epoxy resin in a formulation to obtain thermosetting  polymer, contributing to transform a vegetable oil into  a higher added value product. This work focuses on  the study of the fracture behavior of copolymers based  on anhydride-cured epoxy systems with different contents  of ESO as a replacement for the synthetic resin.  It was found that fracture toughness was greatly  improved when replacing diglycidyl ether of bisphenol  A (DGEBA) by ESO, being the critical stress intensity  factor (KIC) 1.067 MPam1\/2 for cured ESO and 0.557  MPam1\/2 for cured DGEBA. The better performance of  ESO networks was ascribed to its higher ability to  attain plastic deformation. Moreover, for DGEBA-ESO  systems, the morphologies generated during the curing  process were also considered to account for the  observed results.","palabras_clave":"Epoxidized Soybean Oil (ESO)|Thermosets|Morphology|Fracture Behavior"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39966,"idioma_id":4,"titulo":"EFFECTS OF CASTRATION ON ANDROGEN RECEPTORS AND GONADOTROPINS IN THE PITUITARY OF ADULT MALE VISCACHAS","resumen":"The aims of the present study were to detect whether the castration provokes quantitative immunohistochemical changes in the androgen receptors (AR), LH-ir cells and FSH-ir cells; and to analyze the co-localization of androgen receptors (AR) and the gonadotrophins in pituitary pars distalis (PD) of viscachas. Pituitaries were processed for light and electron microscopy. AR-immunoreactive (ir), LH-ir and FSH-ir cells were detected by immunohistochemistry. In the morphometric study, the percentages of AR-ir, LH-ir, FSH-ir, LH-ir\/AR-ir, and FSH-ir\/AR-ir cells were analized. The AR were distributed throughout the PD; they were numerous in the caudal end with intense immunostaining. LH-ir cells   and FSH-ir cells were found mainly in the ventral region and rostral end. About 45%-66% of LH-ir cells and 49%-57% of FSH-ir cells expressed AR in the different PD zones. In castrated animals, a significant decrease of the percentages of AR-ir, LH-ir, FSH-ir, and FSH-ir\/AR-ir cells was observed. Some pituitary cells from castrated viscachas presented ultrastructural changes. These results provide the morphological evidence for gonadal androgens are directly related to the immunolabeling of AR, LH and FSH. Moreover, the co-localization of AR and FSH is the most affected by castration, suggesting the existence of a subpopulation of gonadotrophs with different regulatory mechanisms of hormonal synthesis, storage and secretion activities.","palabras_clave":"Castration|Androgen Receptor|Pituitary|Lagostomus"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39967,"idioma_id":4,"titulo":"Seedling response of Nothofagus species to N and P: linking plant architecture to N\/P ratio and resorption proficiency","resumen":"Previous studieson mature forests of NW Argentinean Patagonia indicated that N is the maingrowth-limiting nutrient in most dominant tree species, while P limitation isuncommon, despite the soils? volcanic origin. This pattern was inferred fromleaf N\/P ratios and resorption proficiencies, but has not been experimentallytested. We conducted a greenhouse trial with seedlings of two deciduous speciesof high timber quality, Nothofagusnervosa and N. obliqua, and soilscharacteristic of each species. Seedlings were fertilized with three levels ofN (100, 200 and 400 mg kg-1 soil) with or without the concurrentapplication of a single P dose (60 mg kg-1 soil) during their secondgrowing season. Response variables were morphological descriptors of shoot androot growth, N and P concentrations in green and senescent leaves, andectomycorrhizal infection. Both species were primarily limited by N: theaddition of N resulted in higher shoot and root masses, an increased number ofnodes, taller stems, and greater basal and root diameters, while no effect of Pwas found. N\/P ratios in green leaves and N and P resorption proficiencies indicatethat with increased N availability P can become a secondary limiting nutrientfor N. nervosa. This was accompaniedby the maintenance of ectomycorrhizal infection and mass allocation to roots inthis species. The steep growth response of N.obliqua to N addition may signal a strong competitive capacity of thisspecies when growing in soils of high N availability.","palabras_clave":"Mass allocation|volcanic soils|architectural descriptors;|mycorrhizal infection"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39968,"idioma_id":4,"titulo":"Online Video Summarization Based on Local Features","resumen":"        Digital video has become a very popular media in several  contexts, with an ever expanding horizon of applications and uses. Thus, the  amount of available video takes is growing almost limitless. For this reason,  video summarization continues to attract the attention of a wide spectrum of  research efforts. In this work we present a novel video summarization technique  based on tracking local features among consecutive frames. Our approach  operates on the uncompressed domain, and requires only a small set of  consecutive frames to perform, thus being able to process the video stream  directly, and to produce results on the fly. We tested our implementation with  standard available datasets, and compared the results with the most recent  published work in the field. The achieved results are similar or better in  quality than the best performing proposals, with the additional advantage of  being able to process the stream directly in the uncompressed domain.  ","palabras_clave":"Computer vision| key-frame detection|video summarization|local features"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39969,"idioma_id":5,"titulo":"Uso industrial del agua en Mendoza, Argentina: coeficientes para la industria alimenticia","resumen":"Aproximadamente el 50% de los establecimientos industriales de la provincia de Mendoza, Argentina se concentra en los rubros de alimentos y bebidas. En zonas áridas como ésta, el consumo y la eficiencia en el uso del agua requieren de especial atención en todos los sectores de la demanda: doméstico, riego, industrial y ambiental. Las industrias de Mendoza utilizan fundamentalmente agua subterránea, ya sea para refrigerar, como materia prima o para la limpieza en distintas partes del proceso productivo; en este último caso, con retorno al sistema hídrico. El conocimiento del volumen de agua que utilizan tales industrias es importante para diversas aplicaciones, como el cálculo del agua virtual de los productos, y para la realización de balances hídricos que incorporan los usos sectoriales en el nivel de cuenca. Para conocer el consumo de agua por parte de la industria alimenticia de Mendoza, el presente trabajo propone utilizar coeficientes que relacionen volumen de agua con materia prima procesada o producto elaborado. Éstos se pueden aplicar para efectuar las estimaciones por cuenca del volumen de agua utilizada por tales industrias. Los coeficientes primarios se obtuvieron a partir de entrevistas presenciales en industrias con diferentes escalas de producción, tales como bodegas, cerveceras, elaboradoras de bebidas no alcohólicas, y conserveras de frutas y hortalizas. Asimismo, para cada rama de actividad se explica el uso de agua en el proceso. Los valores de coeficientes obtenidos a partir de las entrevistas se compararon con aquellos provenientes de bibliografía local e internacional","palabras_clave":"uso del agua|industrias alimenticias|coeficientes|Mendoza"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39970,"idioma_id":5,"titulo":"Uso de agua en industrias de elaboración de conservas de tomate y de durazno de Mendoza, Argentina","resumen":"El objetivo de este trabajo es conocer, a nivel de cuenca, el volumen de agua utilizado por las industrias de elaboración de conservas de tomate y de durazno de Mendoza. Para ello se  stima la materia prima utilizada en la elaboración de estas conservas a partir de datos de superficie cultivada para tal destino y de rendimientos por superficie obtenidos en el Registro  ermanente de Uso de la Tierra de Mendoza y el Instituto Nacional de Tecnología Agropecuaria. Se emplearon coeficientes de volumen de agua utilizada por unidad de materia prima  rocesada, que varían entre 5 y 25 L kg-1 de producto procesado, sin incluir el uso de agua para riego en fincas. Los resultados se analizaron para diferentes valores de coeficientes  sociados a la eficiencia del uso del agua, en escenarios optimista y pesimista. Se concluye que las industrias elaboradoras de conservas de tomate y de durazno de Mendoza utilizan  ntre  ,66 y 6,15 hm3\/año. El mayor consumo de agua de las conserveras de tomate ocurre en la cuenca Norte, alcanzando el 64,9% del total demandado por tales industrias. Para las  onserveras de durazno, el mayor consumo se produce en la cuenca Sur con un 46% de total demandado","palabras_clave":"uso del agua|industrias conserveras|cuencas hídricas|Mendoza"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39971,"idioma_id":5,"titulo":"Experiencias e interpretaciones en performances rituales (Iruya y El Cajón, noroeste argentino)","resumen":"Este artículo se propone reflexionar acerca del modo en que dos performances rituales del noroeste argentino recrean en sus puestas en escena diferentes experiencias. Desde un enfoque etnográfico apoyado en los respectivos trabajos de campo de las autoras, se analizan comparativamente la Fiesta Patronal de la Virgen del Rosario de Iruya (Salta) y la Semana Santa de El Cajón (Catamarca). En particular, se discuten algunas de las razones por la cuales en un contexto ritual la puesta en escena implica la recreación de su historia sociocultural y política, mientras que en el otro el eje central transcurre reactualizando eventos cosmológicos. El marco teórico utilizado se basa en el concepto de performance y su relación con la experiencia, siguiendo los aportes realizados por Edward Bruner (1986) y Victor Turner (1982, 1985, 1986, 1987).","palabras_clave":"RITUAL |PERFORMANCE|IRUYA|EL CAJON"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39972,"idioma_id":5,"titulo":"Riesgo social: Medición de la vulnerabilidad en grupos focalizados","resumen":"    El trabajo provee un marco  metodológico para la medición del riesgo y la vulnerabilidad social. Constituye  el primer paso de una investigación más amplia que se propone construir  indicadores socioeconómicos que aborden la cuantificación del riesgo de un país  superando el análisis de riesgo basado en indicadores financieros. A partir de  una definición de factores objetivos y subjetivos de riesgo social y su  distribución en categorías entre la población de menores ingresos, en esta  etapa la investigación toma como unidad de análisis un caso testigo de un grupo  socioeconómico focalizado, constituido por trabajadores autogestionados del  Partido de La Matanza de la Provincia de Buenos Aires. La finalidad perseguida  es identificar y testear abordajes teóricos y empíricos de la medición de la  vulnerabilidad, tales como variables, relaciones y metodologías cuanti-cualitativas  aplicables.  ","palabras_clave":"Riesgo |vulnerabilidad social|medicion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39973,"idioma_id":4,"titulo":"Game theory in models of pedestrian room evacuation","resumen":"We analyze the pedestrian evacuation of a rectangular room with a single door considering a lattice gas scheme with the addition of behavioral aspects of the pedestrians. The movement of the individuals is based on random and rational choices and is affected by conflicts between two or more agents that want to advance to the same position. Such conflicts are solved according to certain rules closely related to the concept of strategies in game theory, cooperation and defection. We consider game rules analogous to those from the Prisoner?s Dilemma and Stag Hunt games, with payoffs associated to the probabilities of the individuals to advance to the selected site. We find that, even when defecting is the rational choice for any agent, under certain conditions, cooperators cantake advantage from mutual cooperation and leave the room more rapidly than defectors.","palabras_clave":"Game Theory|Complex systems"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39974,"idioma_id":4,"titulo":"Space use by foragers consuming renewable resources","resumen":"We study a simple model of a forager as a walk that modifies a relaxing substrate. Within itsimplicity, this provides an insight on a number of relevant and non-intuitive facts. Even without memory of the good places to feed and no explicit cost of moving, we observe the emergence of a finite home range.We characterize the walks and the use of resources in several statistical ways, involving the behavior of the average used fraction of the system, the length of the cycles followed by the walkers, and the frequency of visits to plants. Preliminary results on population effects are explored by means of a system of two non directly interacting animals. Properties of the overlap of home ranges show the existence of a set of parameters that provides the best utilization of the shared resource.","palabras_clave":"RANDOM WALK|SELF PROPELING|MATHEMATICAL ECOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39975,"idioma_id":4,"titulo":"Crimes against Humanity: The Role of International Courts","resumen":"We study the role of international tribunals, like the International Criminal Court (ICC), as an effective way of reducing the          number and\/or gravity of crimes against humanity. The action of the ICC is directed against leaders that promote or tolerate          these   kinds of crimes, that is, political authorities, army commanders, civil   leaders, etc. In order to simulate the action of the          ICC we build a hierarchical society where the most important leaders have the highest connectivity and can spread their          points of view, or their orders, through a chain of less but still highly connected deputy chiefs or opinion chieftains. In this          way, if they practice misconduct, corruption, or any kind of discriminatory or criminal actions against individuals or groups,          it would very difficult and improbable that they will be prosecuted by the courts of their own country. It is to alleviate this          situation that the ICC was created. Its mission is to process and condemn crimes against humanity though a supranational          organism that can act on criminal leaders in any country. In this study, the action of the ICC is simulated by removing the          corrupt leader and replacing it by a ??decent?? one. However, as the action of the corrupt leader could have spread among          the   population by the time the ICC acts, we try to determine if a unique   action of the ICC is sufficient or if further actions are          required, depending on the degree of deterioration of the human rights in the hypothetical country. The results evidence          the positive effect of the ICC action with a relatively low number of interventions. The effect of the ICC is also comparedwith the action of the local national judiciary system","palabras_clave":"Statistical Mechanics|Complex Networks|Social dynamics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39976,"idioma_id":4,"titulo":"Analysis of genetic population structure in Acacia caven (Leguminosae, Mimosoideae) comparing one exploratory and two Bayesian model based methods","resumen":"Bayesian clustering as implemented in STRUCTURE or GENELAND are widely used to form genetics groups of populations or individuals. On the other hand, in order to satisfy the need for less computer intensive approaches, multivariate analyses are specifically devoted to extracting information from large datasets. In this paper, we use a data set of AFLP markers belonging to 15 sampling sites of Acacia caven to study the genetic structure and compare the consistency of three methods (STRUCTURE, GENELAND and DAPC). Of these methods, DAPC resulted the fasted one and showed accuracy on inferring the K number of populations (K=12 using the find.clusters option and K=15 with a priori information of populations). GENELAND in addition, gives information of the area of membership probabilities for individuals or populations in the space, when coordinates are specified (K=12). STRUCTURE also inferred the number of K populations and the membership probabilities of individuals based on ancestry, giving K=11 without prior information of populations and K=15 using the LOCPRIOR option. Finally, in this work all methods have shown high consistency on estimating the population structure, inferring similar numbers of populations and the membership probabilities of individuals to each group with a high correlation between each other.","palabras_clave":"ACACIA CAVEN|AFLP |GENELAND|DAPC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39977,"idioma_id":4,"titulo":"Morphometric trait differentiation between a wild and a mass-reared population of Anastrepha fraterculus (Diptera: Tephritidae)","resumen":"The South American fruit fly Anastrepha fraterculus (Wiedemann) is an important pest in many countries. The sterile insect technique is an effective method of controlling Ceratitis capitata (Wiedemann) in Argentina and has been proposed for use against A. fraterculus. Because this technique relies on sterile mass-reared males mating with wild females, it is essential to verify that artificial rearing does not reduce&nbsp; male mating competitiveness. Several morphometric characters were evaluated to detect differences between a wild population and a&nbsp; laboratory strain that was derived from it and reared artificially since 1997. Eight morphometric traits were analysed as indicators of body size,head shape and potential mobility: Thorax Length, Head Width, Face Width, Eye Length, Wing Length, Wing Width, Third Tibia Length and Femur Length. The results were analysed using multivariate analysis of variance, linear multiple regression and logistic multiple regression. In general, laboratory flies were larger than wild ones (possibly because the larval diet was supplied ad libitum). Laboratory males had significantly larger Head Width and Eye Length and a smaller Wing Width than wild males. Laboratory females differed from wild ones only by having narrower wings. These results could be due to environmental and genetic factors, or as a consequence of genetic drift (for the latter) during colony establishment plus gradual adaptation to laboratory conditions, where flight ability is most likely less important (resources are found easily at close distances). Also, short-distance interactions among individuals are more frequent in a colony, possibly favouring increased facial trait sizes by sexual selection. Because long-term morphological changes could represent the beginning of intraspecific differentiation, they should probably be worthy of some consideration if a large mass-rearing colony is established.","palabras_clave":"ADAPTATION|ARTIFICIAL REARING|MORPHOMETRIC|SIT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39978,"idioma_id":4,"titulo":"Modeling the microbial growth of two 'Escherichia coli' strains in a multi-substrate environment","resumen":"The microbial growth in multi-substrate environments may be viewed as an optimal resourcesallocation problem. The optimization aims at maximizing some biological objective like the biomass growth.The models developed using this hypothesis are called 'cybernetic' and they represent the complex cell structure as an optimizing function that regulates the intracellular enzymatic machinery. In this work, a cybernetic model was developed to represent the growth of two 'E. coli' strains (JM 109 and BL 21 ?DE3?) on a medium containing glucose and glycerol as carbon and energy sources. The model was able to accurately simulate the biomass growth, the substrates consumption and the growth-rate profiles.","palabras_clave":"Cybernetic model|Optimal control|Glycerol|-"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39979,"idioma_id":4,"titulo":"THE EVOLUTION OF A MID-CRUSTAL THERMAL AUREOLE AT CERRO TORO, SIERRA DE FAMATINA, NW ARGENTINA","resumen":"Amore than 12 kmwide sheeted tonalite complex in western Sierra de Famatina, NWArgentina,was emplaced at middle crust levels (ca. 5 kbar), coeval with regional metamorphism during an early phase of the Ordovician  Famatinian orogeny (ca. 480 Ma). Advective heat fromthe tonalite complex caused a rise in the host regional temperatures (&#8804;700 °C) by amaximum of ca. 100 °C, developing an aureole (~3 kmwide) parallel to the igneous contact. This was accompanied by significant melting (ca. 40%) of the host rocks that hybridized to a variable extent with the tonalitic magmas. Three metamorphic zones were distinguished in a cross-section through the aureole: (1) an external zone consisting of metatexitic gneisses, amphibolites and minor tonalites, (2) an intermediate  zone formed by screens of highly melted gneisses, amphibolites and metagabbros lying between tonalite and newly formed leucogranitoid and hybrid rock sheets, and (3) an internal zone formed almost exclusively ofmassive tonalite and minor hybrid rocks. Incongruent melting of biotite in gneisses of the intermediate zone produced peritectic cordierite and garnet. Hybrids resulting from variable mixing of anatectic granitoids and tonalite magma developed in the innermost part of the aureole at 750?800 °C. Increased water activity within this zone eventually promoted increased melting of plagioclase + quartz in the gneisses. Leucogranitoid magmas formed in part by extraction from the hybrid magmas led to heterogeneity of the Sr-isotope composition. The Cerro Toro contact aureole shows that assimilation of metasedimentary rocks through partial melting can play an important role during emplacement of tonalitic magmas at mid-crustal levels.","palabras_clave":"I-type magmatism|Middle crust emplacement|Anatexis|Hybridization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39980,"idioma_id":4,"titulo":"Coexistence of Localized and Itinerant Electrons in the Double-Perovskite Ba2Fe2\/3Mo4\/3O6","resumen":"A polycrystalline Ba2Fe2\/3Mo4\/3O6   double-perovskite has been prepared by decomposition of citrate   precursors and subsequent thermal treatment under a reducing atmosphere.   The crystal structure has been studied by combined X-ray and neutron   powder diffraction (XRPD and NPD). At room temperature, the structure is   cubic (Fmm) with lattice parameter a = 8.0710(1) Å. It is unchanged between 3 and 320 K. The crystallographic formula is Ba2[Fe0.52(2)Mo0.48(2)]4a[Fe0.14(2)Mo0.86(2)]4bO5.9(2).   NPD, electron spin resonance (ESR), and magnetization measurements show   spontaneous magnetization below the Curie temperature (TC) = 310 K. The ESR behavior is associated with the presence of localized Fe3+   ions, whereas the transport properties (electrical conductivity and   Seebeck effect) suggest the presence of highly correlated electrons in a   metallic band with disorder, which can be associated with the Mo t2g electrons. The coexistence of localized and itinerant electrons leads to non-negligible magnetoresistance properties.","palabras_clave":"Iron|Molybdenum|Mixed-valent compounds|Magnetic properties|Perovskite phases"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39981,"idioma_id":4,"titulo":"Fluoxetine potentiation of omega-3 fatty acid antidepressant effect: Evaluating pharmacokinetic and brain fatty acid-related aspects in rodents","resumen":"We previously reported that combined administration of fluoxetine at antidepressant doses renders additive antidepressant effects while non-antidepressant doses potentiate the omega-3 fatty acid antidepressant effect. We aimed the present study to evaluate putative pharmacokinetic and brain omega-3 fatty acid-related aspects for fluoxetine potentiation of omega- 3 fatty acid antidepressant effect in rats. Co-administration of omega-3 fatty acids with a non-antidepressant dose of fluoxetine (1mg\/kg\/day) failed to affect both brain fluoxetine concentration and norfluoxetine plasma concentration profile. Fluoxetine plasma concentrations remained below the sensitivity limit of the detection method. Either antidepressant (10 m\/kg\/day) or non-antidepressant (1 mg\/kg\/day) doses of fluoxetine in combination with omega-3 fatty acids increased hippocampal docosapentaenoic acid (DPA, 22:5 omega-3) levels. While individual treatments had no effects on DPA concentration, DPA increase was higher when omega-3 were combined with the non-antidepressant dose of fluoxetine. Chronic DPA administration exerted antidepressant-like effects in the forced swimming test while increasing hippocampal docosahexaenoic (22:6 omega-3) and DPA levels. Our results suggest no pharmacokinetic interaction and reveal specific hippocampal DPA changes after fluoxetine and omega-3 combined treatments in our experimental conditions. The DPA role in the synergistic effect of fluoxetine and omega-3 combined treatments will be for sure the focus of future studies.","palabras_clave":"OMEGA-3 FATTY ACIDS|ANTIDEPRESSANTS|FLUOXETINE|FORCED SWIMMING TEST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39982,"idioma_id":4,"titulo":"From rumors to genetic isolates","resumen":"Here we propose a registration process for population genetic isolates, usually geographic clusters of genetic disorders, based on the systematic search of rumors, defined as any type of account regardless of its reliability. Systematically ascertained rumors are recorded, and validated through a progressive process of pre-established steps. This paper outlines the conceptual basis for this approach and presents the preliminary results from a rumor-based nationwide registry of genetically isolated populations, named CENISO (Censo Nacional de Isolados), operating in Brazil since 2009. During the first four years of its existence (2009-2013), a total of 191 Rumors were registered and validated, resulting in a prevalence rate of one per million inhabitants of Brazil. When the five statutory geographic regions of Brazil were considered, more Rumors were registered for the Northeast (2.11; 1.74-2.54 per 10(6)) than for the remaining four regions, North, Center-West, Southeast, and South, which did not differ among themselves. About half (86\/191) of the recorded rumors were proven to be geographic clusters; of these disorders, 58 were autosomal recessive, 17 autosomal dominant, 5 X-linked, 3 multifactorial, and one environmental (thalidomide embryopathy).","palabras_clave":"Brazil; |genetic diseases; |disease clustering; |population registers; rumors"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39983,"idioma_id":5,"titulo":"Neriinae (Diptera: Neriidae) new records for Corrientes and Chaco, Argentina","resumen":"        El  presente documento proporciona los registros de cuatro especies de Neriidae, Nerius  pilifer Fabricius, Nerius plurivittatus Bigot,  Eoneria blanchardi Aczél, 1951 y Eoneria aczeli Sepúlveda y  Carvalho, 2013, para las provincias de Chaco y Corrientes. Nerius  pilifer se capturó en ambas provincias y  es una nueva cita para el nordeste de Argentina. N. plurivittatus fue  capturado en Mburucuyá (Corrientes), E. blanchardi y E. aczeli en  Colonia Benítez (Chaco). N. plurivittatus y E. aczeli son nuevas  citas para Argentina.      ","palabras_clave":"Neriidae|New Records|Chaco|Corrientes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39984,"idioma_id":4,"titulo":"Presence of Genus Pterois (Oken, 1817) (Scorpaeniformes, Scorpaenidae):     Extension of Invasive range in Caribbean Sea and First Published Record for Los Frailes Archipelago","resumen":"            The present work reports the presence of Lionfish (Pterois volitans) in Los Frailes Archipelago, Venezuela. This is the first published record of Lionfish presence for this location and the extension of their invasive range to the South-East of the Caribbean Sea. Pterois volitans) in Los Frailes Archipelago, Venezuela. This is the first published record of Lionfish presence for this location and the extension of their invasive range to the South-East of the Caribbean Sea. ","palabras_clave":"Lionfish|Invasive range expansion|Caribbean Sea|Los Frailes Archipelago"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39985,"idioma_id":4,"titulo":"Optimization of Metal Oxide Gas Sensor in Electronic Nose to Monitor Odor Profiles of Garlic Scape","resumen":"Response of metal-oxide sensors based on tin dioxide ${rm SnO}_{2}$ (P and T) and chromium titanium oxide, and on tungsten oxide (LY) were used to analyze different cultivars of garlic scapes. Temperature and time for sample incubation were set at two temperatures (40 $^{circ}{rm C}$ and 50 $^{circ}{rm C}$ ) and at two incubation times (6 and 10 min). All the sensors presented saturation at 50 $^{circ}{rm C}$ . A temperature set at 40 $^{circ}{rm C}$ had optimal responses for all the sensors. Conditions established in the first place (40 $^{circ}{rm C}$ during 6-min incubation) were used to evaluate five types of different cultivars of fresh garlic scape in order to evaluate sensors. Linear discrimant analysis with Wilks´ lambda stepwise method was applied to investigate the grouping of garlic scapes as a function of the cultivar. Two discriminant functions ( ${rm DF}_{1}$ and ${rm DF}_{2}$ ) were obtained that explained 93.7% and 5% of the total variance, respectively. On the other hand, the same cultivars were analyzed among storage (three days). Data showed that changes among storage could be detected by LY, T, and P sensors among each cultivar (LY and T for Sureño; L for Castaño; P for Gostoso; LY, P, and T for Fuego and P for Morado). Differences among odor are related to the amount of volatile compounds (allicins and sulfide compounds) present, which are presumed to be responsible - or their distinct flavors and aromas in each cultivar.","palabras_clave":"Odour profile|garlic scope"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39986,"idioma_id":4,"titulo":"Structural, spectroscopic and theoretical studies on dixanthogens. (ROC(S)S)2, with R= n-propyl and isopropyl","resumen":"Structural and conformational properties of two dixanthogen molecules, [CH3(CH2)2OC(S)S]2 and [(CH3)2CHOC(S)S]2,   have been analyzed using a combined experimental and theoretical   approach, with data obtained from structural X-ray diffraction methods,   IR, Raman and UV-visible spectroscopies, and DFT calculations. [(CH3)2CHOC(S)S]2 crystallizes in the monoclinic P21\/c space group with a = 9.735(1) Å, b = 12.588(3) Å, c = 12.131(2) Å, &#946; = 112.65(1)°, and Z = 4 molecules per unit cell. The interactions in the crystal were modelled and interpreted by NBO analysis. [CH3(CH2)2OC(S)S]2   is liquid at room temperature, and the vibrational spectra were   satisfactorily explained in terms of the equilibrium between three   conformers, originating from the rotation of the two terminal CH3?   groups, in agreement with the DFT predictions. The electronic spectra   of both dixanthogens were assigned with the assistance of the TD-DFT   calculations.","palabras_clave":"Structural|Spectroscopy|Dixanthogens"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39987,"idioma_id":4,"titulo":"Grassroots innovation movements: challenges and contributions","resumen":"Technologies for social inclusion in Latin America are a recent manifestation of grassroots innovation movements whose global activities go back to appropriate technology in the 1970s and earlier. Common to these movements is a vision for innovation processes more inclusive towards local communities in terms of knowledge, processes and outcomes. A comparison in this article between movements for technologies for social inclusion now and appropriate technology in the past reveals three enduring challenges for grassroots innovation: attending to local specificities whilst simultaneously seeking wide-scale diffusion; being appropriate to existing situations that one ultimately seeks to transform; and, working with project-based solutions to goals (of social justice) whose root causes rest in structures of economic and political power. Each challenge effectively frames grassroots innovation differently, and responses generate valuable forms of knowledge production: grassroots ingenuity; grassroots empowerment; and structural critique. Overall, these movements contribute valuable plurality and reflexivity to innovation policy and politics.","palabras_clave":"Inclusive innovation|Appropriate technology|Technologies for social inclusion|Latin America"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39988,"idioma_id":4,"titulo":"Selective synthesis of p-ethylphenol by gas- phase alkylation of phenol with ethanol","resumen":"The selective synthesis of p-ethylphenol from gas-phase alkylation of phenol with ethanol was studied on zeolites HZSM5 and HMCM22 at 523K. Phenol reacted directly with ethanol to form ethylphenylether by O-alkylation, and p- and o-ethylphenol isomers by C-alkylation; secondary products were m-ethylphenol and dialkylated compounds. Both zeolites presented similar activity and formed low amounts of ethylphenylether and dialkylated products, but exhibited different ethylphenol isomers distribution. In fact, for a contact time of 99.3 g h\/mol the selectivity to p-ethylphenol was 51.4% on HMCM22 and only 14.2% on HZSM5. The superior performance of zeolite HMCM22 for selectively producing p-ethylphenol was due to its narrower pore channels that suppressed the formation of dialkylated products and hampered by diffusional constraints the formation of o-ethylphenol. The maximum p-ethylphenol yield obtained on HMCM22 was 41% at a contact time of 250 g h\/mol; for higher contact times, p-ethylphenol was increasingly converted to m-ethylphenol. All the samples deactivated on stream because of coke formation. The carbon amount built on HMCM22 diminished when contact time was increased thereby indicating that coke was mainly formed from the reactants. Additional catalytic runs showed that phenol was the main responsible of catalyst deactivation, probably because of its strong adsorption on surface active sites.","palabras_clave":"p-Ethylphenol|Ethylphenols|Alkylation|Phenol"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39989,"idioma_id":4,"titulo":"Study of gas phase m-cresol alkylation with methanol on solid acid catalysts","resumen":"The gas-phase alkylation of m-cresol with methanol was studied at 523 K on Al-MCM-41 and zeolites ZnY, HBEA, HZSM5 and HMCM22. The acidity was determined by ammonia TPD and FTIR of adsorbed pyridine.On acid sites of moderate strength (Al-MCM-41), initially the O-alkylation rate was higher than the C-alkylation rate. In contrast, formation of dimethylphenols by C-alkylation was highly favored on ZnY and HMCM22 which have both strong acidity although different  nature; Lewis (ZnY) and Brønsted and Lewis (HMCM22). High selectivity of 2,5-DMP was observed on HZSM5, probably due to diffusional constraint. All catalysts,  except Al-MCM-41, showed deactivation by coke formation.","palabras_clave":"gas-phase alkylation|solid acid catalysts|zeolites|O-alkylation"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39990,"idioma_id":4,"titulo":"Divergent Neuronal Circuitries Underlying Acute Orexigenic Effects of Peripheral or Central Ghrelin: Critical Role of Brain Accessibility","resumen":"Ghrelin is an octanoylated peptide hormone that potently and rapidly increases food intake. Theorexigenic action of ghrelin involves the hypothalamic arcuate nucleus (ARC), which is accessibleto plasma ghrelin and expresses high levels of the ghrelin receptor. Local administration of ghrelinin a variety of other brain nuclei also increases food intake. It is currently unclear, however,whether these non-ARC ghrelin brain targets are impacted by physiological increases of plasmaghrelin. Thus, the present study aimed to clarify which ghrelin brain targets participate in theshort-term orexigenic actions of ghrelin. First, c-Fos induction into mouse brains centrally orperipherally treated with ghrelin was analysed. It was confirmed that peripherally administeredghrelin dose-dependently increases food intake and mainly activates c-Fos in ARC neurones. Bycontrast, centrally administered ghrelin activates c-Fos in a larger number of brain nuclei. Todetermine which nuclei are directly accessible to ghrelin, mice were centrally or peripherallyinjected with a fluorescent ghrelin tracer. It was found that peripherally injected tracer mainlyaccesses the ARC, whereas centrally injected tracer reaches most brain areas known to expressghrelin receptors. Subsequently, the effects of ghrelin were tested in ARC-ablated mice and itwas found that these mice failed to increase food intake in response to peripherally administeredghrelin but fully responded to centrally administered ghrelin. ARC-ablated mice showed patternsof ghrelin-induced c-Fos expression similar to those seen in control mice with the exceptionof the ARC, where no c-Fos was found. Thus, peripheral ghrelin mainly accesses the ARC, whichis required for the orexigenic effects of the hormone. Central ghrelin accesses a variety ofnuclei, which can mediate the orexigenic effects of the hormone, even in the absence of anintact ARC.","palabras_clave":"ARCUATE NUCLEUS|MONOSODIUM GLUTAMATE| DORSAL VAGAL COMPLEX"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39991,"idioma_id":4,"titulo":"Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons","resumen":"The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in food intake and energy expenditure regulation.MC4R activation modifies neuronal activity but the molecular mechanisms by which this regulation occurs remain unclear. Here,we tested the hypothesis that MC4R activation regulates the activity of voltage-gated calcium channels and, as a consequence,synaptic activity. We also tested whether the proposed effect occurs in the amygdala, a brain area known to mediate the anorexigenic actions of MC4R signaling. Using the patch-clamp technique, we found that the activation of MC4R with its agonist melanotan II specifically inhibited 34.5 1.5% of N-type calcium currents in transiently transfected HEK293 cells. This inhibition wasconcentration-dependent, voltage-independent and occluded by the Gaspathway inhibitor cholera toxin. Moreover, we found thatmelanotan II specifically inhibited 25.92.0% of native N-type calcium currents and 55.414.4% of evoked inhibitory postsynaptic currents in mouse cultured amygdala neurons.In vivo, we found that the MC4R agonist RO27-3225 increased the markerof cellular activity c-Fos in several components of the amygdala, whereas the N-type channel blockerxconotoxin GVIA increasedc-Fos expression exclusively in the central subdivision of the amygdala. Thus, MC4R specifically inhibited the presynaptic N-typechannel subtype, and this inhibition may be important for the effects of melanocortin in the central subdivision of the amygdala.","palabras_clave":"amygdala|calcium channels|melanocortin receptor|mouse"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39992,"idioma_id":4,"titulo":"Remarks on the entanglement entropy for gauge fields","resumen":"In gauge theories the presence of constraints can obstruct expressing the global Hilbert space as a tensor product of the Hilbert spaces corresponding to degrees of freedom localized in complementary regions. In algebraic terms, this is due to the presence of a center --- a set of operators which commute with all others --- in the gauge invariant operator algebra corresponding to finite region. A unique entropy can be assigned to algebras with center, giving place to a local entropy in lattice gauge theories. However, ambiguities arise on the correspondence between algebras and regions. In particular, it is always possible to choose (in many different ways) local algebras with trivial center, and hence a genuine entanglement entropy, for any region. These choices are in correspondence with maximal trees of links on the boundary, which can be interpreted as partial gauge fixings. This interpretation entails a gauge fixing dependence of the entanglement entropy. In the continuum limit however, ambiguities in the entropy are given by terms local on the boundary of the region, in such a way relative entropy and mutual information are finite, universal, and gauge independent quantities.","palabras_clave":"Entanglement entropy|Gauge fields"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39993,"idioma_id":4,"titulo":"Ecological Correlates of Group-Size Variation in a Resource-Defense Ungulate, the Sedentary Guanaco","resumen":"For large herbivores, predation-risk, habitat structure and population density are often reported as major determinants of group size variation within and between species. However, whether the underlying causes of these relationships imply an ecological adaptation or are the result of a purely mechanistic process in which fusion and fragmentation events only depend on the rate of group meeting, is still under debate. The aim of this study was to model guanaco family and bachelor group sizes in contrasting ecological settings in order to test hypotheses regarding the adaptive significance of group-size variation. We surveyed guanaco group sizes within three wildlife reserves located in eastern Patagonia where guanacos occupy a mosaic of grasslands and shrublands. Two of these reserves have been free from predators for decades while in the third, pumas often prey on guanacos. All locations have experienced important changes in guanaco abundance throughout the study offering the opportunity to test for density effects. We found that bachelor group size increased with increasing density, as expected by the mechanistic approach, but was independent of habitat structure or predation risk. In contrast, the smaller and territorial family groups were larger in the predator-exposed than in the predator-free locations, and were larger in open grasslands than in shrublands. However, the influence of population density on these social units was very weak. Therefore, family group data supported the adaptive significance of group-size variation but did not support the mechanistic idea. Yet, the magnitude of the effects was small and between-population variation in family group size after controlling for habitat and predation was negligible, suggesting that plasticity of these social units is considerably low. Our results showed that different social units might respond differentially to local ecological conditions, supporting two contrasting hypotheses in a single species, and highlight the importance of taking into account the proximate interests and constraints to which group members may be exposed to when deriving predictions about group-size variation.","palabras_clave":"GRASSLANDS|HABITATS|POPULATION DENSITY|POPULATION ECOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39994,"idioma_id":4,"titulo":"Corrosion behaviour of Nitinol alloy coated with alkylsilanes and polypyrrole","resumen":"Nitinol (equiatomic Ni and Ti alloy (NiTi)) substrate was modified using a coating system formed by a self-assembled film of alkylsilane compounds (propyltrichlorosilane (C3H7SiCl3) or octadecyltrichlorosilane (C18H37SiCl3)) and polypyrrole (PPy) doped with sodium bis(2-ethylhexyl) sulfosuccinate (Aerosol OT or AOT). The combination of alkylsilanes and the presence of a voluminous molecule like AOT entrapped into the PPy films improve the pitting corrosion resistance of the substrate in chloride solution. The best performance was achieved with the longest alkylsilane chains, where the PPy film remains adhered to the underlying coating after a pitting corrosion test.","palabras_clave":"Nitinol alloy|Alkylsilanes|Polypyrrole|Electropolymerisation|Corrosion protection."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39995,"idioma_id":4,"titulo":"Neuroscience and education: prime time to build the bridge","resumen":"As neuroscience gains social traction and entices media attention, the notion that education has much to benefit from brain research becomes increasingly popular. However, it has been argued that the fundamental bridge toward education is cognitive psychology, not neuroscience. We discuss four specific cases in which neuroscience synergizes with other disciplines to serve education, ranging from very general physiological aspects of human learning such as nutrition, exercise and sleep, to brain architectures that shape the way we acquire language and reading, and neuroscience tools that increasingly allow the early detection of cognitive deficits, especially in preverbal infants. Neuroscience methods, tools and theoretical frameworks have broadened our understanding of the mind in a way that is highly relevant to educational practice. Although the bridge?s cement is still fresh, we argue why it is prime time to march over it.","palabras_clave":"COGNITIVE PSYCHOLOGY|NEUROSCIENCE|EDUCATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39996,"idioma_id":4,"titulo":"Parsing heuristic and forward search in first-graders game-play behavior","resumen":"Seventy-three children between 6 and 7 years of age were presented with a problem havingambiguous subgoal ordering. Performance in this task showed reliable fingerprints: 1) a non-monotonic dependence of performance as a function of the distance between the beginningand the end-states of the problem, 2) very high levels of performance when the first move wascorrect and 3) states in which accuracy of the first move was significantly below chance. Thesefeatures are consistent with a non-Markov planning agent, with an inherently inertial decisionprocess, and that uses heuristics and partial problem knowledge to plan its actions. We applieda statistical framework to fit and test the quality of a proposed planning model (Monte-CarloTree Search (MCTS)). Our framework allows us to parse out independent contributions toproblem-solving based on the construction of the value function and on general mechanismsof the search process in the tree of solutions. We show that the latter are correlated with chil-dren?s performance on an independent measure of planning, while the former is highly domainspecific.","palabras_clave":"Heuristics|Stochastic Behavior Modeling|Monte-Carlo Tree Search|Planning|Children Problem Solving|N-Puzzles|First Graders"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39997,"idioma_id":5,"titulo":"Variables socio-organizacionales y sociodemográficas de alto impacto en los procesos de acoso laboral","resumen":"El presente trabajo se centra en indagar el papel de la ?variable ambiente? y las condiciones sociodemográficas de los trabajadores en la predicción de los procesos de acoso laboral.   Tanto las condiciones del trabajo como las de su organización y las características de los grupos de trabajadores son ubicadas por algunas investigaciones como elementos que contribuyen a la emergencia de situaciones de acoso laboral. Éstas se diferencian a su vez de estudios de precursores basados en las fuentes interaccionales y en las estructuras de personalidad.   El objetivo de este trabajo es presentar los resultados vinculados a la exploración e identificación de factores organizacionales y sociodemográficos asociados a la emergencia de situaciones de acoso laboral.   Se indagaron las siguientes variables y su relación con el acoso laboral: edad, sexo, nivel de estudios, tipo y tamaño de la organización, trayectoria laboral, antigüedad, tipo de contrato, autotipificación como víctima de acoso y tenencia de gente a cargo.   Se trabajó con un análisis de regresión múltiple por el método de pasos sucesivos, detectándose relación en tamaño de la organización, posición jerárquica, tipo de organización, nivel de estudios, trayectoria laboral y edad.  Se analizan estas variables al interior de un modelo que las reagrupa en habilitantes, motivadoras y catalizadoras.","palabras_clave":"FACTORES PREDICTORES|ACOSO LABORAL|VARIABLE AMBIENTE|VARIABLES SOCIODEMOGRÁFICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39998,"idioma_id":4,"titulo":"Pre-Exposure Embrittlement and Stress Corrosion  Cracking of Magnesium Alloy AZ31B in Chloride  Solutions","resumen":"Stress corrosion cracking of Mg-Al-Zn AZ31B alloy was studied in sodium chloride solutions at different potentials and sodium chloride concentrations using the slow strain rate technique. Results showed that stress-strain curves were similar despite changes in potential and chloride concentration. In addition, pre-exposure tests were performed in sodium chloride solutions at the open circuit potential followed by immediate straining or straining after a dry-air exposure delay. The dependence of ductility with pre-exposure time, the reversibility of embrittlement, and the fracture surface of pre-exposed samples suggested that AZ31B alloy was susceptible to internal hydrogen embrittlement. Stress corrosion cracking and the pre-exposure embrittlement of this alloy in sodium chloride environments are explained assuming that crack growth rate was controlled by hydrogen diffusion.","palabras_clave":"HYDROGEN INDUCED CRACKING|SSRT|DIFFUSION|CORROSION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":39999,"idioma_id":5,"titulo":"Clave de líquenes creciendo sobre cemento y hormigón en la provincia de Buenos Aires, Argentina","resumen":"Los líquenes crecen sobre una gran variedad de sustratos, entre estos los materiales fabricados por el hombre. Este trabajo se centra en los líquenes que son capaces de crecer sobre cemento. Se colectaron los líquenes hallados sobre hormigón, morteros de cemento y revoques de estructuras en áreas urbanas y rurales de varias localidades de la provincia de Buenos Aires. Lasmuestras se observaron bajo microscopio estereoscópico y óptico y además se realizaron las reacciones histoquímicas usuales y se observaron caracteres vegetativos y reproductivos. Se confeccionó una clave enfatizando las características que pueden verse a simple vista. Se registraron 28 especies de las cuales se presenta una pequeña descripción con caracteres adicionales no presentes en la clave.","palabras_clave":"Cemento|Hormigón|Líquenes|Buenos Aiers"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40000,"idioma_id":4,"titulo":"Phenotypic, Molecular and Symbiotic Characterization of the Rhizobial Symbionts of D e s m a n t h u s p a s p a l a c e u s (Lindm.) Burkart That Grow in the Province of Santa Fe, Argentina","resumen":"Desmanthus paspalaceus (Lindm.) Burkart belongs to the D. virgatus complex, subfamily Mimosoidae. The known potentialas livestock fodder of several of these legumes prompted us to undertake a phenotypic, molecular, and symbioticcharacterization of the D. paspalaceus symbionts in the Santa Fe province, Argentina. The rhizobia collected?containingisolates with different abiotic-stress tolerances?showed a remarkable genetic diversity by PCR fingerprinting, with 11different amplification profiles present among 20 isolates. In selected isolates 16S-rDNA sequencing detected mesorhizobia(60%) and rhizobia (40%) within the collection, in contrast to the genus of the original inoculant strain CB3126?previouslyisolated from Leucaena leucocephala?that we typified here through its 16S rDNA as Sinorhizobium terangae. The resultsrevealed the establishment by diverse bacterial genera -rhizobia, sinorhizobia, and mesorhizobia- of full N2-fixing symbioticassociations with D. paspalaceus. This diversity was paralleled by the presence of at least two different nodC allelic variants.The identical nodC alleles of the Mesorhizobia sp. 10.L.4.2 and 10.L.5.3 notably failed to group within any of the currentlydescribed rhizo-\/brady-\/azorhizobial nodC clades. Interestingly, the nodC from S. terangae CB3126 clustered close tohomologs from common bean nodulating rhizobia, but not with the nodC from S. terangae WSM1721 that nodulates Acacia.No previous data were available on nod-gene phylogeny for Desmanthus symbionts. A field assay indicated that inoculationof D. paspalaceus with the local Rhizobium sp. 10L.11.4 produced higher aerial-plant dry weights compared to S. terangaCB3126?inoculated plants. Neither the mesorhizobia 10.L.4.2 or 10.L.5.3 nor the rhizobium 10L.11.4 induced root nodules inL. leucocephala or P. vulgaris. The results show that some of the local isolates have remarkable tolerances to several abioticstresses including acidity, salt, and temperature; while exhibiting prominent N2 fixation; thus indicating suitability ascandidates for inoculation of D. paspalaceus.","palabras_clave":"RHIZOBIAL SYMBIONTS |DESMANTHUS PASPALACEUS|SYMBIOTIC CHARACTERIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40001,"idioma_id":4,"titulo":"Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range","resumen":"Cell signaling systems sense and respond to ligands that bind cell   surface receptors. These systems often respond to changes                                in the concentration of extracellular   ligand more rapidly than the ligand equilibrates with its receptor. We   demonstrate,                                by modeling and experiment, a general   ?systems level? mechanism cells use to take advantage of the information   present in                                the early signal, before receptor binding   reaches a new steady state. This mechanism, pre-equilibrium sensing and   signaling                                (PRESS), operates in signaling systems in   which the kinetics of ligand-receptor binding are slower than the   downstream signaling                                steps, and it typically involves transient   activation of a downstream step. In the systems where it operates,   PRESS expands                                and shifts the input dynamic range,   allowing cells to make different responses to ligand concentrations so   high as to be otherwise                                indistinguishable. Specifically, we show   that PRESS applies to the yeast directional polarization in response to   pheromone                                gradients. Consideration of preexisting   kinetic data for ligand-receptor interactions suggests that PRESS   operates in many                                cell signaling systems throughout biology.   The same mechanism may also operate at other levels in signaling   systems in which                                a slow activation step couples to a faster   downstream step.","palabras_clave":"levaduras|señalización|gradiente|feromona"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40002,"idioma_id":4,"titulo":"Manipulating transverse modes of photons for quantum cryptography","resumen":"Several schemes have been proposed to extend quantum key distribution protocols aimed at improving their security or at providing new physical substrates for qubit implementation. We present a toolbox to jointly create, manipulate, and measure qubits stored in polarization and transverse-modes degrees of freedom of single photons. The toolbox includes local operations on single qubits, controlled operations between the two qubits, and projective measurements over a wide variety of nonlocal bases in the four-dimensional space of states. We describe how to implement the toolbox to perform an extended version of the BB84 protocol for this Hilbert space (ideally transmitting two key bits per photon). We present the experimental implementation of the measurement scheme both in the regimes of intense light beams and with single photons. Thus, we show the feasibility of implementing the protocol, providing an interesting example of a method for quantum information processing using the polarization and transverse modes of light as qubits.","palabras_clave":"spatial modes|quantum cryptography|extended bb84"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40003,"idioma_id":4,"titulo":"Multi-Criteria Decision Model based on AHP and Linguistic Information","resumen":"Multi-Criteria Decision Analysis (MCDA) is a usual activity among organisations and decisions related to people?s activities. Due to the complexity of considering multiple criteria, to select an alternative is a non-trivial task. From operative levels to managerial ones, MCDA is implemented by using several (formal and informal) techniques. Two useful techniques that help to make a decision are the Analytic Hierarchy Process (AHP) and MCDA models based on Linguistic Information (LI). This work describes a MCDA framework that combines the mentioned techniques in order to provide more confidence in the decision making process. To test the proposed model, framework was used to select the adequate network configuration to improve quality of service (QoS). Finally, the framework?s outputs were compared to real experts? opinions obtaining satisfactory results. Keywords: IPv6 deployment, IPv6 transition solutions, performance analysis, DNS64, TOTD, security, cache poisoning attack, random permutation","palabras_clave":"MCDA|framework|AHP|decision making techniques"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40004,"idioma_id":4,"titulo":"Applying the Analog Configurability Test Approach in a Wireless Sensor Network Application","resumen":"This work addresses the application of the analog configurability test (ACT) approach for an embedded analog configurable  circuit (EACC), composed of operational amplifiers and interconnection resources that are embedded in the MSP430xG461x  microcontrollers family. This test strategy is particularly useful for in-field application requiring reliability, safe operation, or fault  tolerance characteristics. Our test proposal consists of programming a reduced set of available configurations for the EACC and  testing its functionality bymeasuring only a few key parameters. The processor executes an embedded test routine that sequentially  programs selected configurations, sets the test stimulus, acquires data from the internal ADC, and performs required calculations.  The test approach is experimentally evaluated using an embedded system-based real application board. Our experimental results  show very good repeatability, with very low errors. These results show that the ACT proposed here is useful for testing the  functionality of the circuit under test in a real application context by using a simple strategy at a very low cost.","palabras_clave":"-"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40005,"idioma_id":4,"titulo":"A Performance Evaluation of Oscillation Based Test in Continuous Time Filters","resumen":"This work evaluates the ability of OBT for detectingparametric faults in continuous-time filters. To this end, we adopttwo filters with quite different topologies as cases of study and apreviously reported statistical fault model. In addition, we explorethe behavior of the test schemes when a particular test condition ischanged. The new data reported here, obtained from a faultsimulation process, reveal a lower performance of OBT not observedin previous work using single-deviation faults, even under the changein the test condition.","palabras_clave":"Testing|analog fault simulation|analog filter test|oscillation based test"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40006,"idioma_id":5,"titulo":"Estimación de las tensiones de crecimiento en individuos selectos de Eucalyptus camaldulensis mediante extensómetro  e índice de rajado","resumen":"La implantación de Eucalyptus camaldulensis en el NOA puede ser una alternativa importante para solucionar el desabastecimiento de madera aserrada en la región; sin embargo hay escasa información sobre los defectos originados por las tensiones de crecimiento. En este contexto los objetivos del trabajo fueron evaluar las tensiones de crecimiento mediante el extensómetro y el índice de rajado (IR), como así también estudiar la correlación existente entre los diferentes métodos empleados. Los resultados obtenidos evidenciaron que las mediciones con el extensómetro no manifestaron diferencias significativas entre las orientaciones cardinales. El incremento máximo de rajaduras se produjo a las 48 h de apeado y fue suficiente la medición de una sola cara para su determinación. Se observó además una relación altamente significativa y positiva entre el IR a las 48 h y las mediciones con extensómetro, permitiendo explicar el 61% de la variabilidad de las rajaduras producidas.","palabras_clave":"TENSIONES DE CRECIMIENTO|EXTENSÓMETRO|ÍNDICE DE RAJADO|EUCALYPTUS CAMALDULENSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40007,"idioma_id":4,"titulo":"STRUCTURAL AND THERMODYNAMIC PROPERTIES OF WATER-MEMBRANE INTERPHASES:  SIGNIFICANCE FOR PEPTIDE\/MEMBRANE INTERACTIONS","resumen":"Water appears as a common intermediary in the mechanisms of interaction of proteins and polypeptides with membranes of different lipid composition. In this review, how water modulates the interaction of peptides and proteins with lipid membranes is discussed by correlating the thermodynamic response and the structural changes of water at the membrane interphases.    The thermodynamic properties of the lipid-protein interaction are governed by changes in the water activity of monolayers of different lipid composition according to the lateral surface pressure. In this context, different water populations can be characterized below and above the phase transition temperature in relation to the CH2 conformers´ states in the acyl chains.    According to water species present at the interphase, lipid membrane acts as a water state regulator, which determines the interfacial water domains in the surface. It is proposed that those domains are formed by the contact between lipids themselves and between lipids and the water phase, which are needed to trigger adsorption-insertion processes. The water domains are essential to maintain functional dynamical properties and are formed by water beyond the hydration shell of the lipid head groups. These confined water domains probably carries information in local units in relation to the lipid composition thus accounting for the link between lipidomics and aquaomics. The analysis of these results contributes to a new insight of the lipid bilayer as a non-autonomous, responsive (reactive) structure that correlates with the dynamical properties of a living system.","palabras_clave":"LIPID MEMBRANES|AQUEOUS INTERPHASES|WATER OrGANIZATION|THERMODYNAMIC RESPONSE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40008,"idioma_id":4,"titulo":"A MICROTHERMODYNAMIC INTERPRETATION OF FLUID STATES FROM FTIR MEASURES IN LIPID MEMBRANES: A MONTE CARLO STUDY","resumen":"Fourier Transform Infrared spectroscopy (FTIR) is usually employed to obtain transition temperatures of lipids and lipid mixtures and the effect on it of several effectors, such as cholesterol. However, no interpretation of the molecular information provided by the frequency shift to higher values observed at Tc is available. In this paper, we demonstrate that data obtained by means of FTIR measurements contain information about the microscopic thermodynamics of the lipid phase transition. By means of Monte Carlo simulation, we have been able to show that the frequency shift from low to high values can be taken as a two state transition of molecular constituents in a lattice rearrangement. According to the model, at temperatures below Tc all the groups are defined in the lowest energy state defined by the lowest frequency value and therefore they are all connected in a gel lattice. Above Tc, some groups may reach different energy states depending on the restrictions imposed to the groups. Ideally, when all the groups are able to reach the highest frequency, a fully ?fluid? state is reached, we mean disordered states. Taken this hypothetical state as reference it is possible to show that the higher states become less accessible. The model is suitable to describe the effect of cholesterol, which is able to dump the phase transition, and is congruent with previous data denoting that in the so-called fluid phase the first 4-5 methylene groups remain in the gel state even above Tc. The frequency value attained above Tc depends on the nature of the lipid acyl chain.  Keywords: methylene groups, FTIR, lipid membranes, asymmetric frequency shift, Monte Carlo,","palabras_clave":"METHYLENE GROUPS|FTIR|LIPID MEMBRANES|MONTECARLO SIMULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40009,"idioma_id":4,"titulo":"Deciphering the metabolic pathways influencing heat and cold responses during post-harvest physiology of peach fruit","resumen":"Peaches are highly perishable and deteriorate quickly at ambient temperature. Cold storage is commonly used to prevent fruit decay; however, it affects fruit quality causing physiological disorders collectively termed chilling injury (CI). To prevent or ameliorate CI, heat treatment is often applied prior to cold storage. In the present work, metabolic profiling was performed to determine the metabolic dynamics associated with the induction of acquired CI tolerance in response to heat shock. Dixiland peach fruits exposed to 39 °C, cold stored, or after a combined treatment of heat and cold, were compared with fruits ripening at 20 °C. Dramatic changes in the levels of compatible solutes such as galactinol and raffinose were observed, while amino acid precursors of the phenylpropanoid pathway were also modified due to the stress treatments, as was the polyamine putrescine. The observed responses towards temperature stress in peaches are composed of both common and specific response mechanisms to heat and cold, but also of more general adaptive responses that confer strategic advantages in adverse conditions such as biotic stresses. The identification of such key metabolites, which prime the fruit to cope with different stress situations, will likely greatly accelerate the design and the improvement of plant breeding programs.","palabras_clave":"Prunus persica|Chilling injury|Stress"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40010,"idioma_id":4,"titulo":"Surnames, geographic altitude, and digital dermatoglyphics in a male population from the province of Jujuy (Argentina)","resumen":"The possible association between finger dermatoglyphic patterns and altitude and surname distribution was analyzed in a sample of adult males from the province of Jujuy, Argentina.   We also investigated the biological affinity of this population with other South American natives and admixed populations. Fingerprints were obtained from 996 healthy men, aged 18?20 years, from the highlands (HL: 2,500 m, Puna and Quebrada) and lowlands (LL: Valle and Selvas). Surnames were classified into native \/ autochthonous (A) or foreign (F), resulting in three surname classes: FF, when both paternal and maternal surnames were of foreign origin; FA, when one surname was foreign and the other was native; and AA, when both surnames were native. Frequencies of finger dermatoglyphic patterns - arches (A), radial loops (RL), ulnar loops (UL), and whorls (W) - were determined for each digit in relation to geographic location, altitude, and surname origin, resulting in the following categories: HL-FF, HL-FA, HL-AA, LL-FF, LL-FA, and LL-AA. The statistical analyses showed that UL and RL were more common in individuals of HL origin, whereas W and A were more frequent in the LL   males (p<0.05). Significant associations were observed between finger dermatoglyphic patterns and surname origin when geographic altitude was considered. In the HL group, UL was associated with AA and FA; in the LL group, the presence of A was associated with FF and FA. The distribution of dermatoglyphic patterns shows that the population of Jujuy belongs to the Andean gene pool and that it has undergone differential levels of admixture related to altitude.","palabras_clave":"Surnames|geographic altitude|digital dermatoglyphics"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40011,"idioma_id":4,"titulo":"Bonamiosis status in natural Ostrea puelchana beds in San Matías Gulf (Patagonia, Argentina), 14 years after an epizootic","resumen":"ABSTRACT: Between 1995 and 1996, Bonamia exitiosa caused an epizootic in San Matías Gulf,Argentina, that spread from a commercial culture site of Ostrea puelchana to natural beds located at the northeastern coast of the gulf. A mortality rate of 95% was registered in cultured oysters,  and oysters from natural beds were also affected. The aims of this study were to assess the parasite prevalence in oyster beds and the demographic structure 14 yr after the epizootic. Two different oyster beds were studied during 2009 and 2010. Parasite prevalence was studied related to oyster aggregation, density, sex, and oyster size. Prevalence reached 35.3% at Las Grutas and 18.9% at Banco Reparo and was proportionally associated with density. Prevalence was also associated with the type of aggregation in Banco Reparo, where carrier oysters were more infected. Infection was independent of sex category, and infected oysters were larger than the non-infected ones.Oyster density decreased markedly compared to previous studies in both beds and mean sizes were lower, while prevalence doubled. Because of the persistence of the beds in this period, disease seems to control the population structure.","palabras_clave":"Ostrea puelchana|Bonamia exitiosa|Epidemiological study|Survey of prevalence"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40012,"idioma_id":4,"titulo":"Checklist of the Argentine Agaricales 7. Cortinariaceae and Entolomataceae","resumen":"A checklist of species  belonging to the families Cortinariaceae  and Entolomataceae was made for  Argentina. The list included all species published untill year 2012. Nineteen genera  and 444 species were recorded, 370 species from the family Cortinariaceae and 74 from Entolomataceae.  All of them are distributed in 19 genera, the most important being Cortinarius (240 species), Galerina (51), Entoloma (39) and Inocybe (40).  With the exception of Hebeloma (13  species), Gymnopilus (12) and Clitopilus (11), the rest of the 13  genera have less than 10 species each. Galeropsis,  Locellina, Nolanea and Pseudogymnopilus  have only one species each, recorded so far.","palabras_clave":"AGARICALES|BIODIVERSIDAD|CHECK LIST"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40013,"idioma_id":4,"titulo":"Genetic architecture and evolution of the mating type locus in fusaria that cause soybean sudden death syndrome and bean root rot","resumen":"Fusarium tucumaniae is the only known sexually reproducing species among the seven closely related fusaria that cause soybean sudden death syndrome (SDS) or bean root rot (BRR). In a previous study, laboratory mating of F. tucumaniae yielded recombinant ascospore progeny, but required two mating-compatible strains, indicating that it is heterothallic. To assess the reproductive mode of the other SDS and BRR fusaria, and their potential for mating, whole-genome sequences of two SDS and one BRR pathogen were analyzed to characterize their mating type (MAT) loci. This bioinformatic approach identified a MAT1-1 idiomorph in F. virguliforme NRRL 22292 and MAT1-2 idiomorphs in F. tucumaniae NRRL 34546 and F. azukicola NRRL 54364. Alignments of the MAT loci were used to design PCR primers within the conserved regions of the flanking genes APN1 and SLA2, which enabled primer walking to obtain nearly complete sequences of the MAT region for six MAT1-1 and five MAT1-2 SDS\/BRR fusaria. As expected, sequences of the highly divergent 4.7 kb MAT1-1 and 3.7 kb MAT1-2 idiomorphs were unalignable. However, sequences of the respective idiomorphs and those that flank MAT1-1 and MAT1-2 were highly conserved. In addition to three genes at MAT1-1 (MAT1-1-1, MAT1-1-2 and MAT1-1-3) and two at MAT1-2 (MAT1-2-1 and MAT1-2-3), the MAT loci of the SDS\/BRR fusaria also include a putative gene predicted to encode for a 252 amino acid protein of unknown function. Alignments of the MAT1-1-3 and MAT1-2-1 sequences were used to design a multiplex PCR assay for the MAT loci. This assay was used to screen DNA from 439 SDS\/BRR isolates, which revealed that each isolate possessed MAT1-1 or MAT1-2, consistent with heterothallism. Both idiomorphs were represented among isolates of F. azukicola, F. brasiliense, F. phaseoli and F. tucumaniae, whereas isolates of F. virguliforme and F. cuneirostrum were only MAT1-1 and F. crassistipitatum were only MAT1-2. Finally, nucleotide sequence data from the RPB1 and RPB2 genes was used to date the origin of the SDS\/BRR group, which was estimated to have occurred about 0.75 Mya [95% HPD interval: 0.27, 1.68] in the mid-Pleistocene, long before the domestication of the common bean or soybean.","palabras_clave":"Disease management|Fusarium solani species complex|Heterothallic|High mobility group"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40014,"idioma_id":4,"titulo":"Alterations in time estimation in multiple system atrophy","resumen":"Precise spatiotemporal performance is required by many common tasks and represents a basic aspect of cognition. Time estimation in the second-to-minutes range ? known as interval timing ? involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic-glutamatergic pathways. Neurodegenerative disorders such as Parkinson?s disease (PD) and Multiple system atrophy (MSA) are characterized by basal ganglia dysfunction due to dopamine loss. Although interval timing in PD has been  studied, little is known about temporal processing in MSA. In the present work, control, PD and MSA subjects (n=8 for each group) were tested for interval timing in short (15 seconds) duration stimuli. MSA differed significantly from controls and PD patients in terms of decreased accuracy in the timing task. Differences between PD and MSA patients (as well as between MSA and controls)  were lost after levodopa treatment. We show that time estimation for time bins between 5 and 20 seconds is affected in subjects with MSA, who had a significant tendency to underestimate time intervals as compared to controls or PD patients. Recordings of cognitive performance related to timing could be considered useful measurements of the progression of movement disorder-related pathologies.","palabras_clave":"BASAL GANGLIA|DOPAMINE|MULTIPLE SYSTEM ATROPHY|TIME ESTIMATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40015,"idioma_id":4,"titulo":"Forecasting Rainfall Time Series with stochastic output approximated by neural networks Bayesian approach","resumen":"The annual estimate of the availability of the  amount of water for the agricultural sector has become a lifetime in places  where rainfall is scarce, as is the case of northwestern Argentina. This work  proposes to model and simulate monthly rainfall time series from one  geographical location of Catamarca, Valle El Viejo Portezuelo. In this sense,  the time series prediction is mathematical and computational modelling series  provided by monthly cumulative rainfall, which has stochastic output  approximated by neural networks Bayesian approach. We propose to use an  algorithm based on artificial neural networks (ANNs) using the Bayesian  inference. The result of the prediction consists of 20% of the provided data  consisting of 2000 to 2010.   A new analysis for modelling, simulation and  computational prediction of cumulative rainfall from one geographical location  is well presented. They are used as data information, only the historical time  series of daily flows measured in mmH2O. Preliminary results of the annual  forecast in mmH2O with a prediction horizon of one year and a half are  presented, 18 months, respectively. The methodology employs artificial neural  network based tools, statistical analysis and computer to complete the missing  information and knowledge of the qualitative and quantitative behavior. They  also show some preliminary results with different prediction horizons of the  proposed filter and its comparison with the performance Gaussian process filter  used in the literature.                                U.S ISSN : 2158-107X(Print) - See more at: http:\/\/thesai.org\/Publications\/IJACSA#sthash.PIPBThe annual estimate of the availability of the amount of  water for the agricultural sector has become a lifetime in places where  rainfall is scarce, as is the case of northwestern Argentina. This work  proposes to model and simulate monthly rainfall time series from one  geographical location of Catamarca, Valle El Viejo Portezuelo. In this sense,  the time series prediction is mathematical and computational modelling series  provided by monthly cumulative rainfall, which has stochastic output  approximated by neural networks Bayesian approach. We propose to use an  algorithm based on artificial neural networks (ANNs) using the Bayesian  inference. The result of the prediction consists of 20% of the provided data  consisting of 2000 to 2010.   A new analysis for modelling, simulation and  computational prediction of cumulative rainfall from one geographical location  is well presented. They are used as data information, only the historical time  series of daily flows measured in mmH2O. Preliminary results of the annual  forecast in mmH2O with a prediction horizon of one year and a half are  presented, 18 months, respectively. The methodology employs artificial neural  network based tools, statistical analysis and computer to complete the missing  information and knowledge of the qualitative and quantitative behavior. They  also show some preliminary results with different prediction horizons of the  proposed filter and its comparison with the performance Gaussian process filter  used in the literature.                                                                                                                                                                   0&nbsp;                                                                                                                                                                                                                                \t                      \t                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      \t                  Conference Video                                                                                                            \t                              \t                                                                      Science and Information (SAI) Conference is a premier venue for researchers and industry practitioners to share their new ideas!                                                                                                                                                                                                                                                                                                                                                                                                 \t                  Subscribe to our Newsletter                                                                                          \t                                                     - See more at:   http:\/\/thesai.org\/Publications\/ViewPaper?Volume=5&amp;Issue=6&amp;Code=ijacsa&amp;SerialNo=23#sthash.NdLRgaYG.dpuf                                                                                                                                                                  Abstract:   The annual estimate of the availability of the amount of water for the   agricultural sector has become a lifetime in places where rainfall is   scarce, as is the case of northwestern Argentina. This work proposes to   model and simulate monthly rainfall time series from one geographical   location of Catamarca, Valle El Viejo Portezuelo. In this sense, the   time series prediction is mathematical and computational modelling   series provided by monthly cumulative rainfall, which has stochastic   output approximated by neural networks Bayesian approach. We propose to   use an algorithm based on artificial neural networks (ANNs) using the   Bayesian inference. The result of the prediction consists of 20% of the   provided data consisting of 2000 to 2010. A new analysis for modelling,   simulation and computational prediction of cumulative rainfall from one   geographical location is well presented. They are used as data   information, only the historical time series of daily flows measured in   mmH2O. Preliminary results of the annual forecast in mmH2O with a   prediction horizon of one year and a half are presented, 18 months,   respectively. The methodology employs artificial neural network based   tools, statistical analysis and computer to complete the missing   information and knowledge of the qualitative and quantitative behavior.   They also show some preliminary results with different prediction   horizons of the proposed filter and its comparison with the performance   Gaussian process filter used in the literature.                                                                          Keywords: rainfall time series; stochastic method; bayesian approach; computational intelligence                                                                                                                                                                                                                                                                                                                                                                                 0&nbsp;                                                                        0&nbsp;                                                                        0&nbsp;                                                                        0&nbsp;                                                                                                                                                                                                                                \t                      \t                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      \t                  Conference Video                                                                                                            \t                              \t                                                                      Science and Information (SAI) Conference is a premier venue for researchers and industry practitioners to share their new ideas!                                                                                                                                                                                                                                                                                                                                                                                                 \t                  Subscribe to our Newsletter                                                                                          \t                                                     - See more at:   http:\/\/thesai.org\/Publications\/ViewPaper?Volume=5&amp;Issue=6&amp;Code=ijacsa&amp;SerialNo=23#sthash.NdLRgaYG.dpuf","palabras_clave":"rainfall time series|stochastic method|bayesian approach|computational intelligence"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40016,"idioma_id":4,"titulo":"Antifouling activity of celastroids isolated from Maytenus species, natural and  sustainable alternatives for marine coatings","resumen":"A group of celastroids, quinone-methide nortriterpenes isolated from Maytenus vitis-idaea and Maytenus spinosa were assayed for their antifouling activity. Toxicity assays were performed on Balanus amphitrite nauplii, and the most promising compounds were then incorporated in soluble-matrix antifouling paints, which were tested in the ocean. The results obtained after a 45 day-field trial of the paints indicated in all cases promising antifouling potencies. Although all compounds showed antifouling activity on a wide range of organisms, tingenone and celastrol were the most effective inhibitors of the settlement of fouling organisms. The effect of these substances on nauplii in laboratory tests was temporary instead of toxic, with a high recovery rate, which may avert a potentially adverse ecological damage on the benthic community. These results may provide a more environmentally friendly alternative for the control of biofouling, replacing toxic additives actually in use in marine paints","palabras_clave":"Antifouling|Celastroides|Maytenus|Actividad en problemas marinos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40017,"idioma_id":4,"titulo":"Independent Anti-Angiogenic  Capacities of Coagulation Factors X and Xa","resumen":"Knockout models have shown that the coagulation system has a role in vascular  development and angiogenesis. Herein, we report for the first time that zymogen FX and  its active form (FXa) possess anti&#8208;angiogenic properties. Both the recombinant FX and FXa  inhibit angiogenesis in vitro using endothelial EA.hy926 and human umbilical cord vascular  endothelial cells (HUVEC). This effect is dependent on the Gla domain of FX. We  demonstrate that FX and FXa use different mechanisms: the use of Rivaroxaban (RX) a  specific inhibitor of FXa attenuated its anti&#8208;angiogenic properties but did not modify the  anti&#8208;angiogenic effect of FX. Furthermore, only the anti&#8208;angiogenic activity of FXa is PAR&#8208;  1dependent. Using in vivo models, we show that FX and FXa are anti&#8208;angiogenic in the  zebrafish intersegmental vasculature (ISV) formation and in the chick embryo  chorioallantoic membrane (CAM) assays. Our results provide further evidence for the nonhemostatic  functions of FX and FXa and demonstrate for the first time a biological role for  the zymogen FX.","palabras_clave":"ANGIOGENESIS|COAGULATION FACTOR|FX|FXA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40018,"idioma_id":4,"titulo":"Prevalence and determinants of the dual burden of malnutrition at the household level in Puna and Quebrada of Humahuaca, Jujuy, Argentina","resumen":"Objective: The objective of the present study was to identify households in which overweight and underweight coexisted (dual burden of malnutrition) and explore the factors that could be contributing to the dual burden of malnutrition at the household level in this population.  Study design: Cross-sectional nutritional survey.  Methods: After applying the exclusion criteria, 136 households were included. Mothers were classified as normal weight or overweight\/obese based on body mass index (BMI) cut-off points and children and adolescents were classified as stunted or not based on height-for-age z-score. Households with an obese mother and a stunted children or adolescent were categorized as dual burden households.  Results: The prevalence of dual burden household was 12%. Compared with other households, dual burden households tended to have more people living in the house, and the educational level of the head of household was lower.  Individuals living in dual burden households showed overall lower energy intakes and were more likely to have inadequate intakes of calcium and iron.  Conclusions: The nutrition transition in this community might be one of the leading causes of the observed dual burden of malnutrition. The results presented here indicate the need to consider whether programs that focus on only one type of nutritional problem come might actually exacerbate the other.","palabras_clave":"dual burden of malnutrition|household|stunted|overweight|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40019,"idioma_id":4,"titulo":"Assessment of the Quality and Shelf-Life in Enriched n3 PUFA Raw Beef Patties Using Dry Soybean Sprouts as Antioxidant","resumen":"AbstractThe appearance of fresh meat is a major determinant of its appeal to consumers. Ground beef inretail display oxidizes at a faster rate than whole muscle products; the use of antioxidants to breakthe radical chain reaction in the oxidation process is an effective method for slowing oxidation.Soybean is a complex matrix with several bioactive compounds, including peptides and proteins,isoflavones, saponins, and other compounds with antioxidant properties. This study was con-ducted for 1) to evaluate the antioxidant properties of dry soybeans sprouts (DSS) from Glycinemax (L.) Merr., MUNASQA®; 2) to evaluate quality characteristics of raw beef patties added withdried soybean sprouts at different levels (0.5%, 1% and 2%) and soybean oil as a replacer of fat;and 3) to estimate color changes and lipid oxidation of n3 fortified raw beef under frozen storage.Results showed that dry soybean sprouts had a high level of superoxide dismutase enzyme, hightotal phenolics and flavonoids content and appreciable vitamin c content. Although reductionpower was low, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2?-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radicals scavenging activity were elevated. When different concentrationsof DSS were incorporated to enriched beef patties with soybean oil, the nutritional value wasslightly affected, while that n3 and n6 fatty acid content were increased around three twice. Thebeef patties formulated with 1% of natural antioxidant showed significantly (p &lt; 0.05) better colorstability than those without antioxidants. The lipid oxidation was inhibited in all cases, and wasstrongly effective at 1% concentration of DSS being the reduced percent of thiobarbituric acidreactive substances (TBARS) comparable to butilated hydroxianisole (BHA). The results shown inthis research suggest that dry soybeans sprouts could also be used as a cheap natural antioxidantsource for meat products.","palabras_clave":"FRESH MEAT PRODUCTS|NATURAL ANTIOXIDANT|NUTRITIONAL COMPOSITION|LIPID OXIDATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40020,"idioma_id":5,"titulo":"ESTUDIO DEL EFECTO DEL TAMAÑO EN LA ESTRUCTURA CRISTALINA DE NANOPARTÍCULAS DE  CoFe2O4","resumen":"Se estudió como afecta el tamaño de nanopartículas de ferrita de cobalto en el desorden cristalino por efecto de superficie. Las nanopartículas se obtuvieron por el método de coprecipitación de sales. Para controlar el tamaño realizaron diferentes tratamientos térmicos posteriores a  la síntesis. La estructura cristalina y la morfología se evaluaron por medio de Difracción de rayos-X y Microscopía Electrónica de Transmisión de Alta Resolución. Los resultados obtenidos demuestran en forma cuantitativa, cómo la variación en la relación superficie\/volumen es responsable de las deformaciones presentes en las nanoestructuras.","palabras_clave":"FERRITA DE COBALTO|NANOPARTICULAS|DRX|HR-TEM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40021,"idioma_id":4,"titulo":"Behaviour of ionospheric magnitudes of F2 region over Tucumán during a deep solar minimum and comparison with the IRI 2012 model predictions","resumen":"&nbsp;In this paper weanalyze the behavior of the critical frequency of the F2 region of theionosphere (foF2) and the height of the maximum density of free electrons in F2region (hmF2) over Tucumán (26.91S, 294.61E), during the deep solar minimumoccurred in 2008-2009. Data used were compared with those obtained at solarminimum observed in 1975-1976 In addition; we check the validity of theInternational Reference Ionosphere model (IRI), in the version 2012, to predictthe maximum free electron density in the ionosphere (NmF2) above the mentionedstation, for very low solar activity. The results show that: (a) Ionization waslowest for recent solar minimum. (b) The semmianual anomaly which are presentin the behavior of foF2 at times of increased solar activity, was not clearlyobserved during the period 2008?2009. This phenomenon could be related with thevery low solar activity for that period, confirming the relationship of theamplitude of this anomaly with the solar activity reported by other authors.(c) In most cases, the values of hmF2 recorded in the deep solar minimum arelower than those observed in the period 1975-1976, suggesting a decrease in theheight of the ionosphere in the course of time, which could be related to thegreenhouse effect in the atmosphere and the anomalously low solarextreme-ultraviolet irradiance. (d) IRI predictions show significant deviationsfrom the experimental values, indicating the need for improvements in themodel.","palabras_clave":"Ionosonde measurements|F2 layer critical frequency|Solar activity|IRI model"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40022,"idioma_id":4,"titulo":"Unusual nighttime impulsive foF2 enhancements at low latitudes: Phenomenology and possible explanations","resumen":"This paper is focused on unusual nighttime impulsive electron density enhancements that are rarely observed at low latitudes on a wide region of South America, under quiet and medium\/high geomagnetic conditions. The phenomenon under investigation is very peculiar because besides being of brief duration, it is characterized by a pronounced compression of the ionosphere. The phenomenon was studied and analyzed using both the F2 layer critical frequency (foF2) and the virtual height of the base of the F region 2 (h?F) values recorded at five ionospheric stations widely distributed in space, namely: Jicamarca (-12.0°, -76.8°, magnetic latitude -2.0°), Peru; Sao Luis (-2.6°, -44.2°,magnetic latitude +6.2°), Cachoeira Paulista (-22.4°, -44.6°, magnetic latitude -13.4°), and São José dos Campos (-23.2°, -45.9°, magnetic latitude -14.1°), Brazil; Tucumán (-26.9°, -65.4°, magnetic latitude -16.8°), Argentina. In a more restricted region over Tucumán, the phenomenon was also investigated by the total electron content (TEC)maps computed by using measurements from 12 GPS receivers. A detailed analysis of isoheight ionosonde plots suggests that traveling ionospheric disturbances (TIDs) caused by gravity wave (GW) propagation could play a significant role in causing the phenomenon both for quiet and for medium\/high geomagnetic activity; in the latter case however a recharging of the fountain effect, due to electric fields penetrating from the magnetosphere, joins the TID propagation and plays an as much significant role in causing impulsive electron density enhancements.","palabras_clave":"EQUATORIAL IONOSPHERE|ELECTRON DENSITY ENHANCEMENT|TRAVELING IONOSPHERIC DISTURBANCE|FOUNTAIN EFFECT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40023,"idioma_id":4,"titulo":"Adaptive Radar Detection Algorithm Based on an Autoregressive GARCH-2D Clutter Model","resumen":"We propose a model for radar clutter that combines an autoregressive (AR) process with a two dimensional generalized autoregressive conditional heteroscedastic (GARCH-2D) process. Based on this model we derive an adaptive detection test, called AR-GARCH-2D detector, for a target with known Doppler frequency and unknown complex amplitude. Using real radar data we evaluate its performance for different model orders and we use a model selection criteria to choose the best fit to the data. The resulting detector is not constant false alarm rate (CFAR) with respect to the process coefficients, but we show that in practical situations it is very robust. Finally, we compare the AR-GARCH-2D detector performance with the performance of the generalized likelihood ratio test (GLRT), the adaptive linear-quadratic (ALQ) and the autoregressive generalized likelihood ratio (ARGLR) detectors by processing the real radar data. We show that the proposed detector offers a higher probability of detection than the other tests, for a given probability of false alarm.","palabras_clave":"Detection|GARCH processes|GARCH-2D|non- Gaussian clutter"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40024,"idioma_id":4,"titulo":"Emergence of genetically related NDM-1-producing Providencia rettgeri strains in Argentina","resumen":"New Delhi metallo-b-lactamase 1 (NDM-1) was initiallyidentified in Escherichia coli and Klebsiella pneumoniae isolates inSweden from a patient previously hospitalised in India [1]. Accordingto the Antimicrobial Resistance Surveillance Network (Pan AmericanHealth Organization\/World Health Organization), NDM-producers inLatin America have been scarce and associated with species ofEnterobacteriaceae from Guatemala, Mexico, Colombia, Brazil,Uruguay and Costa Rica, although in Honduras and Paraguayit was reported in Acinetobacter. (http:\/\/www.paho.org\/hq\/index.php?option=com_docman&task=doc_view&gid=24472; accessed17.06.14). Here we report the emergence of NDM-1 carbapenemasein Argentina.","palabras_clave":"NDM|Emergence|Enterobacteriaceae|patient previously hospitalised"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40025,"idioma_id":4,"titulo":"Evaluation of the addition of dry soybean sprouts on cooking yield and oxidative stability of enriched beef patties with soybeans oil","resumen":"The improvement of fatty acid profile of beef patties through the replacement of pork back fat with soybean oil can be achieved, but it is necessary to use antioxidants, such as dry soybean sprouts, to maintainthe oxidative stability. Besides, development of functional foods with soybean sprouts as food ingredient opens up new possibilities to their use as natural additive. This work was designed to investigate the effect of the addition of soybean sprouts on the quality characteristics of beef patties with partial replacement of pork back fat by soybean oil duringfrozen storage (90 days at ?18 ± 2 oC). Results showed that addition of soybean sprouts improved protein and carbohydrate content; moisture and oil retention of cooked enriched patties were also enhanced. One percent (1%) of dry soybean sprouts (DSS) concentration was the most effective to retain healthier lipids and minimize the cooking loss. Besides, these products were microbiological stable and had a softer texture than those without soybean sprouts addition. This study indicates thatproximate composition could be improved through incorporation of dry soybean sprouts, and it could be used to protect enriched beef patties from lipid oxidation without modifying their quality characteristics.","palabras_clave":"BEFF PATTIES CHARACTERISTICS |LIPID OXIDATION|NATURAL ANTIOXIDANTS| GLYCINE MAX|HEALTIER LIPIDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40026,"idioma_id":4,"titulo":"DNA content in South American endemic species of Lathyrus","resumen":"    The genome size was surveyed in 13 Notolathyrus    species endemic to South America by flow cytometry    and analyzed in an evolutionary and biogeographic    context. A DNA content variation of 1.7-fold was registered,    and four groups of species with different DNA    content were determined. Although, the 2C values were    correlated with the total chromosome length and intrachromosomal    asymmetry index (A1), the karyotype formula    remained almost constant. The conservation of the    karyotype formula is in agreement with proportional    changes of DNA in the chromosome arms. Species with    annual life cycle and shorter generation time had the lowest    DNA content and the data suggest that changes in DNA    content involved reductions of genome size in the perennial    to annual transitions. The variation of 2C values was correlated    with precipitation of the coldest quarter and, to    some extent, with altitude. Additional correlations with    other variables were observed when the species were    analyzed separately according to the biogeographic    regions. In general, the species with higher DNA content    were found in more stable environments. The bulk of    evidence suggests that changes on genome size would have    been one of the most important mechanisms that drove or    accompanied the diversification of Notolathyrus species.","palabras_clave":"NOTOLATHYRUS|DNA CONTENT|FLOW CYTOMETRY|KARYOTYPE EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40027,"idioma_id":4,"titulo":"Evaluation of enzymatic pectin extraction by a recombinant polygalacturonase (PGI) from apples and pears pomace of Argentinean production and characterization of the extracted pectin","resumen":"Argentina  produces, annually, 1.8 million tons of pome fruit, distributed almost equally  between apple and pear. These fruits, produced in the High Valley of Río Negro  are already a registered brand in the world of fruit. &nbsp;Aspergillus kawachii &nbsp;produces an acidic &nbsp;polygalacturonase (PGase) called PGI that has  attracted considerable interest because of its potential use in the food  industry, &nbsp;particularly those involving  fruit production in this region (such as pectin extraction). The enzyme was  cloned and expressed in &nbsp;Saccharomyces  cerevisiae . The objective of this work was to evaluate the use of PG1 in the  enzymatic pectin extraction from apples and pears pomace. Characterization of  the extracted pectin was also done. The performance of PGI extraction process was  compared to the traditional chemical extraction process and to the enzymatic  extraction with commercial enzymes. The &nbsp;esterification  degree and the content of uronic acids from the pectin obtained were  determined. In all cases, the extraction with PGI had higher yields than the  chemical extraction process. Enzymatic extracted pectins exhibited an  esterification degree&gt; 50% so that they can be considered belonging to the  group of high methoxylpectins. According to these results, PGI could be used to  produce pectins from fruit pomaces converting these materials, currently  considered wastes, into by-products of the fruit industry","palabras_clave":"Polygalacturonase|Pectin extraction|Apples|Pears"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40028,"idioma_id":5,"titulo":"Requerimientos pre-germinativos de Maihuenia patagonica y Maihueniopsis darwinii, cactáceas endémicas de Patagonia","resumen":"Las cactáceas son plantas características de  ecosistemas áridos, en los cuales desarrollan un importante papel ecológico. Se  encuentran amenazadas por la destrucción del hábitat y la extracción con fines  comerciales. Argentina es uno de los países de Sudamérica con mayor riqueza y  nivel de endemismo de cactáceas, sin embargo, su estudio es escaso,  especialmente para las especies de distribución más austral. Dado que un mayor  conocimiento sobre la biología reproductiva de los cactus ayudaría a mejorar su  conservación, se estudiaron aspectos fisiológicos básicos sobre la germinación  de dos especies endémicas de Argentina y Chile, Maihuenia patagonica (Phil.)  Britton  &amp; Rose y Maihueniopsis darwinii (Hensl.) F. Ritter var. hickenii (Britton &amp; Rose) R. Kiesling. Se evaluó el  porcentaje de germinación (G), el tiempo medio de germinación (TMG) y los días  transcurridos hasta el inicio de la germinación (IG) de un control y de tres  tratamientos pre-germinativos: estratificación húmeda fría (EHF),  escarificación mecánica con lija y arena (EML) y escarificación mecánica con  bisturí (EMB). El ensayo se extendió por 60 días, en cámara de germinación a  20\/10°C, 12 h luz\/12 h oscuridad. Para M. patagonica la germinación no  difirió entre la estratificación y el control, pero fue mayor al control en la  escarificación con bisturí. Para M. darwinii var. hickenii la  germinación sólo difirió entre la estratificación y la escarificación con  bisturí. El TMG y el IG fueron mayores para la estratificación que para el  control en M. patagonica, mientras que los tratamientos de  escarificación no difirieron del control. En el caso de M. darwinii var.  hickenii no se observaron diferencias en el TMG, pero el IG fue menor en  la estratificación que en el control. Es posible que ambas especies presenten  algún tipo de dormancia, ya que &nbsp;los  porcentajes de germinación fueron bajos (M. patagonica de 8-27 % y M.  darwinii var. hickenii de 17-26 %) pero las semillas&nbsp; presentaron elevada viabilidad. Se descarta  la existencia de dormancia física debido a que hubo  germinación en el control de ambas  especies y se propone la existencia de dormancia fisiológica no profunda la  cual habría sido superada parcialmente por la escarificación mecánica  con bisturí del tegumento en M. patagonica. Los resultados obtenidos constituyen un  nuevo aporte al estudio de las cactáceas de Sudamérica, que puede ser utilizado  para el desarrollo de medidas de conservación in situ mediante la  restauración de hábitats naturales degradados.","palabras_clave":"Dormancia|Maihuenioideae|Opuntioideae|Payunia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40029,"idioma_id":4,"titulo":"Effect of estradiol cypionate and amount of progesterone in the intravaginal device onsynchronization of estrus, ovulation and on pregnancy rate in beef cows treated with FTAI based protocols.","resumen":"Three experiments were conducted to evaluate the effect of estradiol cypionate (ECP) andamount of progesterone in the intravaginal device (PID) on synchronization of estrus andovulation, follicular dynamics, luteal dynamics and function and on pregnancy rate in beefcows treated with fixed-time artificial insemination (FTAI) based protocols. In Experiment 1,we evaluated the synchronization of ovulation using 1 mg of ECP at PID removal (day 8 afterPID insertion) or 1 mg of estradiol benzoate (EB) 24 h later, in cows treated with 0.558 or 1 gof progesterone (P4). The final subgroups were: 0.558 g + ECP: n = 10; 0.558 g + EB: n = 11;1 g + ECP: n = 10; 1 g + EB: n = 10. Ovarian ultrasonic examinations were performed to detectthe dominant follicle and ovulation. There was no effect of treatments on the diameter ofdominant follicle at any time, and on the mean interval to estrus and to ovulation (P > 0.05);however, ECP treated cows had scattered distribution of estrus (P  0.05) between progesterone content (0.558 g: 52.9%, 55\/104; 1 g: 56.9%, 58\/102)but differed between estradiol esters (P  0.05) between proges-terone content (0.558 g: 48.1%, 52\/108; 1 g: 53.3%, 57\/107) and estradiol esters (ECP: 47.7%,52\/109; EB: 53.8%, 57\/106). In conclusion, ECP administration at device removal and proges-terone content of PID has no influence on the synchronization of estrus, follicular dynamics,luteal dynamics and function. However, ECP administration affected the synchronizationof ovulation and pregnancy rate in non-suckling beef cows, but did not affected pregnancyrate in suckling beef cows. Future studies should evaluate the distribution of ovulations insuckling Bos taurus beef cows.","palabras_clave":"BEEF COWS|ESTRDIOL CYPIONATE|PROGESTERONE|OVULATION SYNCHRONIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40030,"idioma_id":4,"titulo":"Food safety control of zeranol through voltammetric immunosensing on Au-Pt bimetallic nanoparticle surfaces","resumen":"This study reports an accurate and sensitive strategy for zeranol (ZER) determination in bovine urine samples. ZER is a mycotoxin widely used as a synthetic growth promoter in the livestock production whose residues could present a potential risk for human health. Therefore, its use as an animal feed additive has been banned in most countries. ZER determination was accomplished using an electrochemical system in which bimetallic Au?Pt nanoparticles (Au?PtNPs) were electro-synthesized on a screen-printed carbon electrode(SPCE). The obtained Au?PtNP platform was immunofunctionalized using specific anti-ZER antibodies as a strategy to avoid potential interference. After biorecognition, ZER was directly oxidized and detected by square-wave voltammetry (SWV). The Au?PtNP surface was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and cyclic voltammetry (CV). The limit of detection calculated was 0.01 ng mL-1 with a wide linear range from 0.03 to 30 ng mL-1. This method promises to be suitable for ZER quantification in bovine urine samples ensuring food quality and safety, as well as  consumer?s health.","palabras_clave":"zeranol|immunosensing|nanoparticle"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40031,"idioma_id":5,"titulo":"Evaluación de la producción y la calidad de forraje de Thinopyrum ponticum en diferentes sustratos salinos","resumen":"El incremento de la superficie agrícola hacia zonas ganaderas obligo a los sistemas pastoriles a desplazarse hacia suelos con problemas de salinidad y alcalinidad cada vez más frecuentes. Thinopyrum ponticum (agropiro alargado) es una especie utilizada en suelos salinos-sódicos, de aceptable valor nutritivo (Ochoa, 1994) y tolerante a la salinidad (Robinson et al, 2004). Es utilizada en áreas salinizadas o alcalinizadas que comprometen la producción de la mayoría de especies gramíneas forrajeras (Smith, 1986). Conocer cómo se afecta la producción de materia seca y la calidad forrajera en función del contenido y tipo de sales del suelo,  es un tema a considerar para eficientizar el sistema ganadero en este tipo de suelos. El objetivo fue evaluar la producción de materia seca y la calidad de forraje en una población de agropiro alargado bajo diferentes condiciones de sustratos. Si bien la producción de materia seca fue menor en los diferentes sustratos salinos, la concentración de FDN no difirió significativamente para el tratamiento sódico respecto del control. Agrupándose al menos para los parámetros de calidad evaluados, al sustrato control y sódico. De esta manera parecería que el sustrato sódico es el que menos afectó los parámetros de calidad mencionados, en comparación con los sustratos salino y salino-sódico. Sin embargo se debe continuar evaluando la especie (poblaciones, familias y cultivares) en diferentes años y también en condiciones de campo","palabras_clave":"Suelos halo-hidromorficos|Agropiro|Digestibilidad de la FDN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40032,"idioma_id":4,"titulo":"Molecular and Electronic Structure of Self-Assembled Monolayers containing Ruthenium (II) Complexes on Gold Surfaces","resumen":"Ru(II) bipyridyl complexes were covalently bonded to self-assembled monolayers (SAM) on Au surfaces. Their molecular and electronic structure was studied by means of polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS), photoelectron spectroscopies, scanning tunneling microscopy (STM) and density functional theory (DFT) calculations. We found that attaching the Rucomplex to the SAM does not cause great modifications to its molecular structure, which retains the alkyl chain 30 deg tilted with respect to the surface normal. Furthermore, the Ru center is located 20 Å away from the metal surface, i.e., at a sufficient distance to prevent direct electronic interaction with the substrate. Indeed the electronic structure of the Ru complex is similar to that of the free molecule with a HOMO molecular orbital mainly based on the Ru center located 2.1 eV below the Fermi edge and the LUMO molecular orbital based on the bipyridine groups located 1 eV above the Fermi level.","palabras_clave":"SAMs|electronic structure"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40033,"idioma_id":4,"titulo":"Genetic response of Paspalum plicatulum to genome duplication","resumen":"Paspalum plicatulum is a perennial rhizomatous grass with natural diploid and polyploid cytotypes. In this study, we investigated the occurrence of sequence polymorphisms arising immediately after genome autoduplication in this species. Two mixoploid plants (4C and 7D) were previously obtained through colchicine treatment of seeds generated by open pollination of a diploid plant (H14-2x). Diploid and tetraploid sectors from both mixoploids were dissected to generate two ploidy series (4C-2x\/4C-4x and 7D-2x\/7D-4x) &nbsp;Molecular fingerprints were generated from the maternal plant H14-2x, both ploidy series (4C-2x\/4C-4x and 7D-2x\/7D-4x), and a tetraploid plant (C1) produced by selfing 7D-4x. Our results indicate that immediately after polyploidization P. plicatulum suffers genetic rearrangements affecting *28?38 % of the genome. Band gain and loss were equally prevalent at a statistically significant level. At least 5.62 % of the genome experimented recurrent genetic variation in a non-random basis with a confidence of 94.88 %. A significant proportion of novel bands (36 out of 195; 18.4 %) was detected in the C1 tetraploid plant. Half of these bands were not amplified in either H14-2x or 7D-4x, while the remainders were present in H14-2x but absent in 7D-4x. Our results indicate the occurrence of a considerable number of genetic changes in P. plicatulum immediately after polyploidization, some of which were recurrently detected in different independent events. Moreover, we confirmed that after polyploidization, lost ancestral alleles were spontaneously recovered in further generations, a phenomenon previously reported by other research groups.","palabras_clave":"AUTOPOLIPLOIDY|GENETIC RESPONSE|GENOMIC SHOCK|MOLECULAR MARKER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40034,"idioma_id":4,"titulo":"Food safety control of zearalanol through voltammetric immunosensing on Au-Pt bimetallic nanoparticles surface","resumen":"This study reports an accurate and sensitive strategy for &#945;-zearalanol (ZER)determination in bovine urine samples. ZER is a mycotoxin widely used as synthetic growth promoter in the livestock production whose residues could present a potential risk for human health. Therefore, the use of it as animal feed additive has been banned in most countries. ZER determination was accomplished using an electrochemical system in which  bimetallic Au-Pt nanoparticles (Au-PtNPs) were electro-synthesized on screen printed carbon electrode (SPCE). The obtained Au-PtNPs platform was immunofunctionalized with specific anti-ZER antibodies as a strategy to avoid potential interferences. After biorecognition, ZER was directly oxidized and detected by square-wave voltammetry (SWV). The Au-PtNPs surface was characterized by scanning electron microscopy (SEM),X-ray diffraction (XRD) and cyclic voltammetry (CV). The limit of detection calculated was 0.01 ng mL-1 with a wide linear range from 0.03 to 30 ng mL-1. This method promises to be suitable for ZER quantification in bovine urine samples ensuring food quality and safety, as well as consumer?s health.","palabras_clave":"FOOD SAFETY|ZEARALANOL|VOLTAMMETRIC|IMMUNOSENSING |BIMETALLIC NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40035,"idioma_id":5,"titulo":"Sindrome de Ellis Van Creveld: Caso clinico","resumen":"El Síndrome de Ellis Van Creveld es poco frecuente, hereditario de carácter autosómico recesivo no habiendo predilección por sexo. Se caracteriza por acortamiento acromesomélico, polidactilia postaxial bilateral de manos, condrodisplasia de huesos largos y displasia ectodérmica de uñas y dientes. El conocimiento de la misma es imperativo para un diagnóstico temprano y manejo multidisciplinario oportuno que permita una mejor calidad de vida de estos pacientes.","palabras_clave":"Polidactilia|Enfermedads cromosomicas recesivas|Enanismo neonatal"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40036,"idioma_id":4,"titulo":"Immunological Status of Isolated Lymphoid Follicles After Intestinal Transplantation","resumen":"Intestinal transplantation (ITx) faces the challenge of grafting a high immunogenic organ, which is certainly one of the major obstacles for intestinal allograft acceptance. The allograft has to guarantee the proper functioning of the mucosal immune machinery under immunosuppressive conditions. Recently, it has been elucidated that isolated lymphoid follicles (ILFs) are an indispensable part of mucosal immunity to maintain IgA synthesis and consequently to control commensal microflora. No data about these follicular structures in the setting of ITx are available so far. Therefore, we addressed the question whether constitution, integrity and function of allograft ILFs are disturbed by immunosuppressive regimen. We compared allograft ILFs from terminal ileum of transplant patients with ILFs from nontransplant patients via flow cytometry, quantitative real-time polymerase chain reaction and immunohistochemistry. We found that host leukocytes rapidly repopulate allograft ILFs and that maintenance immunosuppressive regimen, tacrolimus and corticosteroids, does not affect their cellular integrity and function. However, allograft ILFs revealed a higher maturation state than control samples and IgA positive plasma cells were increased in number in allograft mucosa. Our results open the path for a better understanding of allograft mucosal immunity.","palabras_clave":"intestinal transplant|isolated lymphoid follicle|intestinal mucosa|imunosupresssion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40038,"idioma_id":5,"titulo":"Análisis de cambios de uso del suelo en la Delegación  Municipal de Ingeniero White (Buenos Aires, Argentina):  aplicación de geotecnologías","resumen":"La Delegación Municipal de Ingeniero   White se encuentra en la provincia de   Buenos Aires, Argentina. Este trabajo   analiza la dinámica de cambio de uso   del suelo en el área mencionada durante   el periodo 1967-2012. La metodología   empleada se basa, por un lado, en el   desarrollo del proceso cartográfico   necesario para la identificación de los   usos del suelo a escala 1:50.000 para   ambos años y, por otro, en la aplicación   del método de tabulación cruzada en   un entorno SIG con el fin de evaluar los   cambios ocurridos en el lapso de 45 años.   Los resultados muestran un importante   crecimiento del uso residencial y poca   variación en el resto de los usos.","palabras_clave":"Matriz de transición|Uso del suelo|Sistemas de Información Geográfica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40039,"idioma_id":5,"titulo":"Valoración sustentable de glicerol a monoglicéridos mediante catálisis heterogénea","resumen":"Los biocombustibles son soluciones renovables para reemplazar las contaminantes reservas de combustibles fósiles. Sin embargo, se generan grandes excedentes de glicerol, subproducto del biodiesel. El glicerol se utiliza en cosméticos, alimentos y productos farmacéuticos. Los catalizadores heterogéneos tienen bajo costo y minimizan los problemas ambientales y de proceso generados por los catalizadores homogéneos. En este trabajo se estudian los óxidos metálicos mixtos como catalizadores en la reacción de  transesterificación. Para aumentar la propiedad básica del óxido de Mg-Al se incorporó un tercer metal (Ca o Ba). Los Óxidos metálicos mixtos obtenidos por descomposición térmica de Hidróxidos dobles laminares se estudiaron en la transesterificación de estearato de metilo con glicerol para la producción de monoglicéridos. Los resultados catalíticos mostraron que la conversión y la selectividad a monoglicérido aumentaron junto con la densidad de sitios básicos. El óxido con Ba incorporado por impregnación mostró la mayor densidad de sitios básicos medios y el mejor rendimiento catalítico.","palabras_clave":"Glicerol|Monoglicéridos|Catálisis heterogénea|Óxidos metálicos mixtos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40040,"idioma_id":4,"titulo":"Capacitive (RC) circuits in dc: a university experience using applets","resumen":"Los estudiantes tienen dificultades para la comprensión de los fenómenos físicos transitorios en general, y los que suceden en circuitos resistivo-capacitivos en serie por los que circula corriente continua no escapan a esta problemática. Si bien son muchos los factores que inciden en el proceso de aprendizaje, los autores estiman necesario resaltar: las preconcepciones que influirían en la adecuada interpretación de los fenómenos temporales, la formación previa de los estudiantes en Matemática, el nivel de abstracción de los conceptos involucrados y la presentación del tema que se realiza en la mayoría de los libros de texto de uso habitual (Giacosa, Giorgi, Maidana, 2012).   Por otro lado, las Tecnologías de la Información y de la Comunicación (TIC), han hecho emerger nuevas prácticas y modos de organización social en el mundo del trabajo, el esparcimiento y la educación. En este último ámbito, las computadoras e Internet, han revolucionado de manera inédita las formas de acceder y relacionarse con el conocimiento. Aunque existen numerosos recursos educativos para enseñar Física, son escasos los reportes de investigaciones educativas que dan cuenta de su uso específico en situaciones áulicas en instituciones educativas de América Latina.  El propósito de este trabajo es presentar una investigación centrada en la utilización de simulaciones computacionales, de las denominadas applets, potencialmente útiles para abordar el estudio de carga y descarga de un condensador.   Se diseñaron e implementaron guías didácticas conteniendo las actividades propuestas para realizar experiencias en entornos virtuales integradas a la resolución de problemas de lápiz y papel. Se trabajó con sesenta y dos estudiantes de Ingeniería Química e Ingeniería en Alimentos que cursaron Física II durante el año 2013. Se les solicitó la redacción de informes escritos grupales obteniéndose un total de catorce, que se constituyeron en los documentos sobre los que se aplicó la técnica de análisis de contenido (Bardin, 1996).   Los resultados muestran que la mayoría de los estudiantes operó adecuadamente con los simuladores diseñando y recreando las experiencias solicitadas, no obstante, algunos tuvieron problemas para interpretar gráficos de carga eléctrica o corriente en función del tiempo, y para contrastar los resultados obtenidos analíticamente con los proporcionados por el simulador. A partir de ellos se concluye, en términos generales, que el uso de estos recursos computacionales promovió la comprensión de los modelos físicos que describen el comportamiento físico de un condensador.","palabras_clave":"TIC|CIRCUITOS|RC|UNIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40041,"idioma_id":5,"titulo":"Fosfatasa Alcalina como Marcador Bioquímico de la Enfermedad Periodontal","resumen":"La fosfatasa alcalina es una enzima relacionada con la enfermedad periodontal. Se encuentra en los polimorfonucleares (PMN), osteoblastos, fibroblastos y diversas células del tejido conectivo, jugando un papel importante en el remodelado del tejido óseo y del ligamento periodontal. Posee capacidad predictiva, sus niveles se elevan en los sitios con pérdida de inserción activa, permitiendo la vigilancia del tratamiento periodontal.","palabras_clave":"FOSFATASA ALCALINA|ENFERMEDAD PERIODONTAL|MARCADORES BIOQUÍMICOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40042,"idioma_id":5,"titulo":"Evolución de los ambientes costeros de la Provincia de Buenos Aires (Argentina): Cambio climático o efectos antrópicos?","resumen":"Buenos Aires abarcando el estuario de Bahía Banca y la zona costera externa entre el estuario y la localidad de Monte Hermoso. El objetivo del mismo es proponer modelos de gestión y de gobernanza sustentables administrados por la comunidad en sistemas marinos y costeros con especial énfasis en los aspectos de la pesca artesanal y el turismo. El objetivo del presente trabajo es presentar los cambios que se han observado en la costa en el sector directamente relacionado con el proyecto COMET-LA. Se presentan indicios de que los efectos de la variabilidad climática, aunque necesariamente importantes, quedan supeditados a los efectos antrópicos.","palabras_clave":"CAMBIO CLIMATICO|EFECTOS ANTROPICOS|SISTEMAS COSTEROS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40043,"idioma_id":4,"titulo":"Nanostructured ZnO thin films prepared by sol-gel spin-coating","resumen":"Abstract: ZnO thin films deposited on silica flat plates were prepared by spin-coating and studied by applying several techniques for structural characterization. The films were prepared by depositing different numbers of layers, each deposition being followed by a thermal treatment at 200&#9702;C to dry and consolidate the successive layers. After depositing all layers, a final thermal treatment at 450&#9702;C during 3 h was also applied in order to eliminate organic components and to promote the crystallization of the thin films. The total thickness of the multilayered films ? ranging from 40 nm up to 150 nm ? was determined by AFM and FESEM. The analysis by GIXD showed that the thin films are composed of ZnO crystallites with an average diameter of 25 nm circa. XR results demonstrated that the thin films also exhibit a large volume fraction of nanoporosity, typically 30?40 vol% in thin films having thicknesses larger than ¡­70 nm. GISAXS measurements showed that the experimental scattering intensity is well described by a structural model composed of nanopores with shape of oblate spheroids, height\/diameter aspect ratio within the 0.8?0.9range and average diameter along the sample surface plane in the 5?7 nm range. ","palabras_clave":"ZnO|Nanostructured thin films|XR|AFM|FESEM|GISAXS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40044,"idioma_id":4,"titulo":"POLYSACCHARIDES INFLUENCE ON THE INTERACTION BETWEEN TANNIC ACID AND HAZE ACTIVE PROTEINS IN BEER","resumen":"Colloidal instability in beer is mainly caused by interactions between proteins and polyphenols. These two combine producing a visible haze that reduces the physical shelf life of beer. The haze active proteins (HAPs) react with tannic acid (TA); therefore, this reaction provides a way to determine HAP concentrations in beer. Beers also contain a number of constituents that may influence the protein-polyphenol haze formation. We used a response surface methodology to predict the influence of total polysaccharides (TPS) and proteins on beer haze. Experiments were carried out using the Central Composite Design (CCD) methodology. Samples of beer were prepared with variable concentrations of TPS and proteins. TPS concentrations ranged between 1.34 and 2.23 g L-1 and proteins concentrations between 0.11 and 0.18 g L-1. Results show that the increase in turbidity in response to TPS addition was similar to that in response to protein addition. Our regression analyses indicate asignificant dependency and correlation between the observed values and the predicted response values (R2 = 97.87% and R2[adj] = 95.75%). Furthermore, these values indicate that our experimental model can explain 95.75% of the total variation. Therefore, using TA as an indicator of the interaction of TPS with proteins, as commonly done, can lead to considerable errors, since the polysaccharides also react with TA,and this reaction actually causes a considerable increase in turbidity.","palabras_clave":"POLYSACCHARIDES|INTERACTIONS|PROTEINS|BEER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40045,"idioma_id":4,"titulo":"Solvent Extraction Studies for Separation of Zn(II) and Mn(II) from Spent Batteries Leach Solutions","resumen":"This study aims to assess the possibility of using solvent extraction processes forseparating Zn(II) and Mn(II) dissolved in aqueous solutions obtained by acid bioleachingof spent alkaline and Zn-C batteries. In this context, Cyanex 272 and DEHPA were testedas extractant agents, and the former was shown to have better performance. Hence, theeffect of four factors (equilibrium pH, extractant concentration, A\/O ratio andtemperature) into three response variables (extraction efficiency of Zn, YZn; extractionefficiency of Mn, YMn; separation factor, &#946;) were tested according to a full factorialdesign (24) with two replicated centre points. Our study revealed that YZn depends mainlyon the extractant concentration, YMn on the equilibrium pH and &#946; on the equilibrium pH,extractant concentration and A\/O ratio as well as on second and third order interactions.One extraction step is sufficient to reach high extraction of zinc in synthetic solutions, buttwo stages were required for real leaching liquor. The extraction kinetics is fast (less than15 min) for both metals, even when real liquor was tested. The organic solvent can beefficiently recovered using a stripping solution of H2SO4 1 M and thus the process can beconsidered environmentally sustainable.","palabras_clave":"Solvent extraction; | Spent batteries;| DEHPA; Cyanex 272;| Design of experiments"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40046,"idioma_id":5,"titulo":"Células madre de sangre de cordón umbilical. ¿Quién tiene la palabra?","resumen":"En este artículo analizamos distintos aspectos vinculados a la criopreservación de las células madre, desde una perspectiva bioética ? jurídica.  En primer lugar resulta de interés definir el concepto  de células madre, distinguir distintos tipos y comprender el modo en que, en la actualidad, se procuran y conservan para compartir el universo de significados. Se describen las opciones que surgen en nuestro país, analizando fundamentalmente las diferencias  de concepción que subyacen en relación al cuerpo y sus partes por parte de los biobancos de gestión privada y el biobanco público que funciona en el hospital Garrahan. Se realiza un análisis de la normativa vigente en la República Argentina y la circunstancia surgida a partir de una resolución del INCUCAI que procuró reglamentar el funcionamiento de los biobancos privados. Este análisis da lugar a una reflexión respecto al modo en que se dirimen los conflictos cuando se judicializan circunstancias referidas a la salud y la vida de las personas. Y en este caso particular, una temática novedosa a la que aún es necesario comprender, por su complejidad y por el modo en que irrumpe y da lugar a  un nuevo escenario socio?sanitario.","palabras_clave":"Donación|Células madre |Sangre cordón umbilical|Bioética Jurídica"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40047,"idioma_id":4,"titulo":"Relationships among gene expression and anthocyanin composition of Malbec grapevine clones","resumen":"Anthocyanin profiles are commonly used for grapevine cultivar   identification because it is currently accepted that this trait is   closely related to their genetic characteristics. Nevertheless, the   extent of the variation for the anthocyanin profiles among clones of the   same cultivar has not yet been studied in depth. The relative   concentration of anthocyanins of 131 Malbec clones grown in the same   vineyard was investigated by HPLC-DAD and the use of comprehensive   statistic procedures. Complementarily, the expression level of   structural and regulatory genes was studied via real time polymerase   chain reaction. Significant variation was identified among the profiles   of the clones, mainly due to variations in the amounts of malvidin   derivatives. Finally, the differential expression in F3&#8242;5&#8242;H, OMT1 and AM2   genes seems to be related to the malvidin content variation. This work   shows the existence of variation for the anthocyanin profiles among   clones from the same grapevine cultivar and the putative involvement of   genes related to hydroxylation, methylation, and transport of   anthocyanins on the basis of such variation.","palabras_clave":"anthocyanins|Vitis vinifera|Malbec|gene expression|clone|profile|grapevine"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40048,"idioma_id":4,"titulo":"Latency of bovine herpesvirus type 5 (BoHV-5) in tonsils and peripheral blood  leukocytes","resumen":"Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) can both establish   latency in the trigeminal ganglion. Non-neural sites of latency have   been described for BoHV-1 but not for BoHV-5. The aim of this study was   to determine whether peripheral blood leukocytes and tonsils are targets   for BoHV-5 infection and to establish whether all stages of that   virus´s infectious cycle can occur in those cell types. Comparisons with   BoHV-1 infection of these tissues were also made in order to better   understand the pathogenesis of both viruses. BoHV-1 and BoHV-5 were   isolated from tonsils of acutely-infected calves. BoHV-5 was also   isolated from a tonsil homogenate after dexamethasone-induced   reactivation. During latency, infectious virus was recovered from a   tonsil explant of one BoHV-5-infected calf. The genomes of BoHV-5 and   BoHV-1 were detected in tonsils from acutely-infected calves although   were not detected in tonsils from latently-infected calves or from   calves treated with dexamethasone. Virus DNA was intermittently detected   in leukocytes. The study has shown that BoHV-5 can establish latency in   bovine tonsils and peripheral white blood cells, and that it can be   reactivated from latently-infected tonsils, which might contribute to   viral transmission. The titres of BoHV-1 and BoHV-5 in tonsils were   similar, suggesting that replication at this site is a common feature   for both viruses.","palabras_clave":"Bovine|Herpesvirus"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40049,"idioma_id":4,"titulo":"Permanent superhydrophobic polypropylene nanocomposite coatings by a simple one step dipping process","resumen":"Superhydrophobic nanocomposite coatings on injection-molded polypropylene (PP) samples were preparedby dipping in xylene solvent containing titanium dioxide nanoparticles (NPs) functionalized withtrimethoxypropyl silane. Alternatively, PP samples were dipped in a mixture of functionalized NPs anddissolved PP pellets. As a general result, dip-coated PP samples reached a permanent superhydrophobicstate with a contact angle hysteresis (CAH) depending on NPs concentration and surface chemistry. SEMand profilometer measurements show a general trend in the decrease of CAH with the increase of aggregatesand roughness. However some results showed that surfaces with the same roughness presenteddifferent CAHs. XPS measurements showed that low CAHs and self-cleaning properties were obtainedonly when the Ti?OH relative concentration on the surface was about 20%. At higher Ti?OH relative concentrations,the surface kept a superhydrophobic static state but lost its self-cleaning properties. Thiswork highlights the fact that both control of the roughness together with chemical surface compositionof polar groups have to be taken into account for a precise tuning on the superhydrophobic dynamiccomponent of the surface.","palabras_clave":"Superhydrophobicity  Titanium dioxide Coating|Titanium dioxide nanoparticles|Nanostructuration|Coating"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40050,"idioma_id":4,"titulo":"- Different Synthetic Pathways of Nanoparticle-Cored Dendrimers (NCDs): Effects on the Properties and their Application as Redox Active Centers","resumen":"The synthesis of nanoparticle-cored dendrimers(NCDs) through surface functionalization of iron oxide nanoparticles(c-Fe2O3) by combining the conventional silane couplingagent 3-(aminopropyl) triethoxysilane (APS) withdendritic moieties is studied and presented. Much emphasishas been put on the role played by each modifier and howthey interact not only between themselves, but also with thedispersing media wherein the resulting NCDs are. As a part ofthe functionalization, redox-active nitro groups were introducedonto the surface of each synthesized NCD thus makingthem electrochemically active. Then, the obtained NCDs wereimmobilized onto glassy carbon electrodes. Both the NCDs andmodified electrodes are expected to be eventually exploited inanalytical and sensing applications","palabras_clave":"dendronization|functionalized nanoparticles|cored dendrimers"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40051,"idioma_id":5,"titulo":"Manejo tradicional de las majadas de ovejas criollas del oeste formoseño","resumen":"El objetivo del presente trabajo fue definir las pautas de manejo tradicionales a las que son sometidas las majadas de ovejas criollas en el oeste de la provincia de Formosa. Para ello se trabajó en 20 sitios de muestreos distribuidos uniformemente en el territorio, donde se realizaron encuestas estructuradas (n=82) indagando sobre los aspectos relacionados a los sistemas productivos que poseen ovinos. Para el procesado de los datos se realizó un análisis descriptivo. La mayoría   de los productores realiza explotación ganadera mixta (87,5%), combinando producción de ganado mayor con menor, el resto produce solo ganado menor (12,5%) ambos utilizan mano de obra familiar. Las existencia media ovina es de 52 cabezas por productor, estratificándose de la siguiente manera: menos de 50(63,5%), entre 51 y 100(27,1%), entre 101 y 200(7,1%) y más de 200(2,4%). La estructura de la majada se compone de: ovejas (70%), borregas de reposición (23,3%), carneros (3,9%) y carneritos de reposición (2,8%).La totalidad de los productores realiza pastoreo con encierre nocturno que rondan las 8 horas de duración, desplazándose los animales a distancias medias de 1,15 km diarios, tienen perros pastores (58,1%). Durante la época de parición se aparta y retiene las parturientas antes de largar a pastar la majada (52%). Los corderos no salen con las madres al pastoreo durante el primer mes de vida (67,7%). Los corrales no tienen la superficie necesaria de acuerdo al número de animales, ni es costumbre colocar bebederos con agua en los mismos. Solo un bajo porcentaje suplementa a los animales en alguna época del año (25,8%).  El único tratamiento sanitario que se realiza  es la aplicación de antiparasitarios (65,6%). El manejo que se lleva adelante con los ovinos se corresponde a una típica producción de traspatio, donde las mujeres y los niños son los encargados de la atención de de los animales.","palabras_clave":"BIODIVERSIDAD|SEGURIDAD ALIMENTARIA|OVINOS|TRASPATIO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40052,"idioma_id":5,"titulo":"ASPECTOS SOCIOECONÓMICOS DEL SISTEMA DE PRODUCCIÓN DE LA OVEJA CRIOLLA DEL OESTE FORMOSEÑO","resumen":"El objetivo de este estudio fue caracterizar los aspectos socioeconómicos de los sistemas donde son criados los ovinos del oeste de la provincia de Formosa, Argentina. Para ello se trabajó en 20 sitios de muestreos distribuidos uniformemente en el territorio, donde se realizaron encuestas estructurados (n=82) indagando sobre los aspectos relacionados a los sistemas productivos que poseen ovinos, procesando los datos mediante un análisis descriptivo.  El  87,1% de los productores pertenece a la etnia criolla, mientras que el 12,9% a la Qom. La estratificación etaria se distribuye en: menores de 40 años (25,8%), entre 40 y 60 años (35,5%) y más de 60 años (38,7%). El 83,9% reside permanentemente en el predio y el 58,1 desde hace más de 25 años. El 57,1% solo ha tenido acceso a estudios primarios de los cuales el 57,1 no los ha terminado. El 67,7% no integra ninguna forma asociativa, el 54,8% no recibe asistencia técnica de ningún tipo, de los que la reciben el 92% es de origen estatal. En cuanto a la situación legal de la tierra solo el 9,4% posee título de propiedad, mientras que el 50% tiene títulos provisorios y el resto ocupa tierras fiscales. El 74,2% no tiene acceso a la energía eléctrica, el 93% cuenta con agua potable en el predio. Poseen las siguientes construcciones ganaderas: alambrados perimetrales (58,1%), cerramientos internos (54,8%), corrales para ovejas (100%), compartido con caprinos (90,3%), con divisiones (41,9%), manga de manejo (3,2%) y techos (29%). La construcción de los corrales se realiza con palos (54,3%), ramas (22,9%) o tablas (17,1%), los techos se construyen con chapas (55,6%) o  tejas de palma (22,2%). En cuanto al destino que se da a la producción se consumen 60,2% de los corderos mientras que se comercializa el 39,8%, con la categoría de ovejas se reparten ambos destinos a la mitad. La totalidad de los productores esquilan los ovinos al menos una vez al año, y el 58% lo hace dos veces. De acuerdo a los datos relevados, se puede afirmar que es sistema se corresponde al traspatio para subsistencia, dándose al ovino local una relevancia altamente social.","palabras_clave":"CARACTERIZACION|OVINOS|SUBSISTENCIA|TRASPARTIO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40053,"idioma_id":4,"titulo":"Bringing androgens up a NOTCH in breast cancer.","resumen":"While it has been known for decades that androgen hormones influence   normal breast development and breast carcinogenesis, the underlying   mechanisms have only been recently elucidated. To date, most studies   have focused on androgen action in breast cancer cell lines, yet these   studies represent artificial systems that often do not faithfully   replicate\/recapitulate the cellular, molecular and hormonal environments   of breast tumours in vivo. It is critical to have a better   understanding of how androgens act in the normal mammary gland as well   as in in vivo systems that maintain a relevant tumour microenvironment   to gain insights into the role of androgens in the modulation of breast   cancer development. This in turn will facilitate application of   androgen-modulation therapy in breast cancer. This is particularly   relevant as current clinical trials focus on inhibiting androgen action   as breast cancer therapy but, depending on the steroid receptor profile   of the tumour, certain individuals may be better served by selectively   stimulating androgen action. Androgen receptor (AR) protein is primarily   expressed by the hormone-sensing compartment of normal breast   epithelium, commonly referred to as oestrogen receptor alpha (ERa   (ESR1))-positive breast epithelial cells, which also express   progesterone receptors (PRs) and prolactin receptors and exert powerful   developmental influences on adjacent breast epithelial cells. Recent   lineage-tracing studies, particularly those focussed on NOTCH   signalling, and genetic analysis of cancer risk in the normal breast   highlight how signalling via the hormone-sensing compartment can   influence normal breast development and breast cancer susceptibility.   This provides an impetus to focus on the relationship between androgens,   AR and NOTCH signalling and the crosstalk between ERa and PR signalling   in the hormone-sensing component of breast epithelium in order to   unravel the mechanisms behind the ability of androgens to modulate   breast cancer initiation and growth.","palabras_clave":"BREAST CANCER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40054,"idioma_id":5,"titulo":"New distribution record of Cryptotermes brevis (Isoptera, Kalotermitidae) in Argentina","resumen":"The first record of the West Indian drywood termite Cryptotermes brevis (Walker, 1853) in the city of Corrientes (Argentina) is reported. Several C. brevis   colonies were detected inside a local deposit, from wooden crates used   for carrying fresh fruits. The observed damage consisted of small   rounded holes, partially hollowed wood pieces and presence of debris.   The importance of weather factors and the type of material of vegetable   and fruit containers in the colonization and dispersion of C. brevis in this region of Argentina are discussed. Illustrations of soldiers and reproductive C. brevis, and an updated map of the distribution of this termite in Argentina are given.","palabras_clave":"DRYWOOD TERMITES|INSECTA|NEOTROPICS|WOOD-FEEDERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40055,"idioma_id":4,"titulo":"Repeatability of superovulatory response to successive FSH treatments in Merino sheep","resumen":"The efficiency of a multiple ovulation and embryo transfer program depends on the recovery of a large number of viable embryos per donor ewe at each successive superovulatory treatment. Embryo production, however, is characterized by high individual variability in the ovarian response to hormonal treatment. This study evaluated the repeatability of ovarian response and embryo recovery following three successive superovulatory treatments in 10 four-year-old Merino ewes over a short period of time. Oestrus was synchronized using an intravaginal progesterone pessary inserted on Day 0 and removed on Day 14. FSH  was administered to induce superovulation in declining doses twice daily over 3 days as 2(18 + 14 + 8) = 80 mg total commencing on Day 12 after pessary insertion. A dose of 200 IU eCG was administered at pessary removal. Vasectomized rams were used for heat detection and laparoscopic AI was performed 12 h after oestrus detection. Surgical embryo recovery was performed at Day 8 after pessary removal, following which prostaglandin was administered and the next superovulatory procedures began 5 days later giving a 27-day interval between embryo recoveries. Ovulation rates (mean ± SEM) for the three successive superovulatory treatments were 13.8 ± 2.2, 12.1 ± 2.2 and 12.0 ± 2.2 (NS); and total embryos recovered were 8.3 ± 1.4, 6.3 ± 1.4 and 3.9 ± 1.4 (P = 0.06), respectively. Consequently, the embryo recovery rates declined from 66.1 ± 7.5% for the first recovery to 41.4 ± 7.5 and 34.5 ± 7.5% for the second and third recoveries (P = 0.04). The repeatability was r = 0.84 (P < 0.05) for ovulation rate, r = 0.13 (NS) for total number of embryos and r = 0.09 (NS) for number of grade 1 and 2 embryos. The study showed that an average of 16.3 ± 2.6 grades 1 and 2 embryos per donor ewe could be recovered over a period of 2.5 months. The high repeatability of ovarian response to successive superovulatory treatments would have to be associated with a high level of repeatability for the number of transferable embryos recovered for it to be used as a criterion for selecting donors on the basis of their response to the first hormonal treatment.","palabras_clave":"Embryo recovery|Multiple ovulation|Embryo transfer|Sheep"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40056,"idioma_id":5,"titulo":"Vacuna EG95 contra la hidatidosis ovina: su aplicación en un programa piloto en la Provincia de Río Negro","resumen":"La equinococosis quística es una enfermedad endémicaen la Provincia de Río Negro y  en casi toda la Argentina. Luegode 30 añosde programa de control, enmarcado en el Programa Nacional  de control de Enfermedades Zoon óticas, basado en la desparasitación de perros con  praziqua ntel, la tasa de transmisión al hombre y él los ovin os disminuyó signif icat ivamen t e  aunq ue persiste. Para superar esta situación se decidió incor porar a las acciones de control la  vacuna EG95 contra la hidatidosis ovina ampliando ce tal manera las formas de cortar el ciclo de  la enfermedad. La estrategia inicial fu e estruc tura r un programa piloto en ámbito s geográficos  correspondientes a pob lación orig inaria en donde equipos veterinar ios del programa de control  se responsabilizaran de su aplicación, identificando los posibles problemas operativos y evaluando su efecto en limitar  la transmisión en condiciones de campo. El primer estudio de impacto a los tres años mediante enzimo inmunoensayo  western blot (ELlSNW8) 7.3% de los vacunados resultaron positivos, mientras que en el área testigo 39.3% resultaron  positivos siendo las diferencias estadísticamente significativas. Se analizan las costos operativos, las dificultades en terreno  para la aplicación de la vacuna (instalaciones deficientes, amplitud del periodo de parición. venta y movimiento de corderos vacunados, etc ) y las características sociales de la comunidad, como variables para estimar la factibilidad de la inclusión de esta tecnología como herramienta en un programa de control.","palabras_clave":"VACUNA EG95|HIDATIDOSIS OVINA|RIO NEGRO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40057,"idioma_id":5,"titulo":"Uso de un simulador acústico artesanal para la enseñanza de la técnica de biopsia guiada por ultrasonografía en el grado","resumen":"El aprendizaje de maniobras intervencionistas requiere de la adquisición de técnicas y habilidades manuales en modelos antes de proceder a realizarlas en pacientes. Los simuladores acústicos (SA) disponibles en el mercado resultan costosos para la enseñanza y sufren deterioro que tras sucesivas prácticas terminan siendo descartados debido a los daños que reciben. El objetivo del trabajo fue evaluar las propiedades acústicas y factibilidad de uso en el grado de un simulador acústico elaborado por los autores en la enseñanza de las maniobras de punción a mano alzada guiada por ultrasonografía. Se construyeron simuladores  acústicos que fueron ofrecidos a 13 estudiantes avanzados de la carrera de medicina veterinaria. Cada simulador estaba constituido de un medio comprendido por gelatina conteniendo un huevo cocido que ofició de 'neoplasia' que debía ser punzada. Al conjunto de los estudiantes les fueron impartidos los conocimientos de la técnica de punción a mano alzada guiada por ultrasonografía, luego a cada uno les fue entregado un SA. Concluida la experiencia respondieron una encuesta de satisfacción. La totalidad de los estudiantes identificaron la neoplasia, coordinaron  las habilidades manuales a la vez que seguía a la aguja haciendo la punción en el monitor del ecógrafo. El modelo acústico propuesto de fabricación artesanal reunió condiciones acústicas y de ecogenicidad permitiendo el aprendizaje y entrenamiento de la punción guiada con ultrasonografía","palabras_clave":"Ecografía|Punción guiada|Maqueta|Enseñanza"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40058,"idioma_id":5,"titulo":"VALORIZACIÓN DE LOS RECURSOS LOCALES A TRAVÉS DEL EMPODERAMIENTO DE LAS MUJERES INDÍGENAS","resumen":"Las mujeres indígenas   han iniciado un proceso de organización a partir de la valorización de la actividad artesanal, basada en la elaboración de tejidos en lana de oveja criolla del oeste formoseño. En este marco, un proyecto mayor apunta  a identificar los recursos naturales utilizados por las mujeres a lo largo de toda la cadena artesanal, con el objetivo de mejorar la calidad y la utilización de los mismos, logrando un impacto en toda la cadena de producción lanera y en el proceso de empoderamiento de las mujeres. El objetivo de este trabajo es identificar y valorizar el recurso lanero a partir de la intervención de las mismas mujeres en los procesos de selección de animales para la formación de un plantel ex situ, donde se pueda evaluar y multiplicar ejemplares de alta calidad con el fin de generar reproductores superiores. La metodología utilizada fueron encuestas, visitas  y selección de animales superiores de acuerdo al  criterio de las artesanas. Seguidamente se negoció con cada productor un intercambio de esos animales, por otros, para la formación del plantel. Se han utilizado en el primer año estos animales para el dictado de cursos de esquila mecánica a jóvenes provenientes de familias productoras de lana. Las asociaciones de mujeres no han tenido un rol solamente participativo sino que han sido socias permanentes del proceso, evaluando los impactos en su propia producción de las intervenciones realizadas. Se ha logrado un impacto inmediato en la calidad de las artesanías y una mejor inserción en el mercado. También, se ha contribuido a la visibilización de las mujeres como un nuevo actor social, con mayor protagonismo y participación política. Los centros de las artesanas se conforman por 1200 mujeres, que lideran hoy los procesos de innovación en la producción, transformando la actividad artesanal de una actividad económica asociada a lo antiguo y a las generaciones más ancianas, en un sector de innovación y desarrollo que involucra a los jóvenes y que abre nuevas perspectivas de trabajo para las comunidades indígenas de la región.","palabras_clave":"ORGANIZACION|OVINOS|ARTESANIA|GENERO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40059,"idioma_id":5,"titulo":"La cobertura mediática del 7D en la prensa argentina.  Aplicación de encuadres noticiosos genéricos a los principales diarios nacionales","resumen":"El presente artículo procura comparar el tipo de cobertura que tres diarios argentinos (Clarín, La Nación y Página\/12) realizaron del denominado 7D, en alusión al 7 de diciembre de 2012, durante el mes previo y el posterior a esa fecha (del 7 de noviembre al 7 de enero). La base conceptual del estudio es la Teoría del Encuadre. Se realiza una aplicación deductiva de encuadres noticiosos genéricos definidos en trabajos previos con el objetivo de poner en discusión si tales frames son efectivamente adaptables a diversos tópicos, a lo largo del tiempo y en diferentes contextos culturales, o si es necesario considerar las particularidades de dichos escenarios para la definición y persistencia de los encuadres predominantes en las noticias.Indexada en: LATINDEX; Google Scholar Metrics;  Revencyt; ERIH PLUS; Dialnet; Ulrich´s Periodicals Directory; REDIB;  Rebiun; RICYT; SciLit (GRUPO A).","palabras_clave":"FRAMING|DIARIOS ARGENTINOS|LEY DE SERVICIOS DE COMUNICACIÓN AUDIOVISUAL|7D"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40060,"idioma_id":4,"titulo":"Tumor induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes\/macrophages through a mechanism that involves TIM-3 and CD40L","resumen":"Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor  microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune  response. Our previous work showed that tumors induce senescence of T cells, which are powerful suppressors of lymphoproliferation.  In this study, we report that Tumor-Induced Senescent (TIS)-T cells may also modulate monocyte activation. To gain  insight into this interaction, CD4+ or CD8+TIS-T or control-T cells were co-incubated with autologous monocytes under  inflammatory conditions. After co-culture with CD4+ or CD8+TIS-T cells, CD14+ monocytes\/macrophages (Mo\/Ma) exhibit a higher  expression of CD16+ cells and a reduced expression of CD206. These Mo\/Ma produce nitric oxide and reactive oxygen species;  however, TIS-T cells do not modify phagocyte capacity of Mo\/Ma. TIS-T modulated-Mo\/Ma show a higher production of proinflammatory  cytokines (TNF, IL-1&#946; and IL-6) and angiogenic factors (MMP-9, VEGF-A and IL-8) and a lower IL-10 and IP-10  secretion than monocytes co-cultured with controls. The mediator(s) present in the supernatant of TIS-T cell\/monocytemacrophage  co-cultures promote(s) tubulogenesis and tumor-cell survival. Monocyte-modulation induced by TIS-T cells requires  cell-to-cell contact. Although CD4+ shows different behavior from CD8+TIS-T cells, blocking mAbs against T-cell immunoglobulin  and mucin protein 3 and CD40 ligand reduce pro-inflammatory cytokines and angiogenic factors production, indicating that these  molecules are involved in monocyte\/macrophage modulation by TIS-T cells. Our results revealed a novel role for TIS-T cells in  human monocyte\/macrophage modulation, which may have deleterious consequences for tumor progression. This modulation  should be considered to best tailor the immunotherapy against cancer.  Cell Death and Disease (2014) 5, e1507; doi:10.1038\/cddis.2014.451; published online 6 November 2014","palabras_clave":"Senescencia|Cancer"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40061,"idioma_id":4,"titulo":"The long goodbye: the rise and fall of flavodoxin during plant evolution","resumen":"        Ferredoxins are electron shuttles harboring iron-sulfur clusters which  connect        multiple oxido-reductive pathways in organisms displaying different  lifestyles.        Some prokaryotes and algae express an isofunctional electron carrier,        flavodoxin, which contains flavin mononucleotide as cofactor. Both  proteins        evolved in the anaerobic environment preceding the appearance of  oxygenic        photosynthesis. The advent of an oxygen-rich atmosphere proved  detrimental to        ferredoxin due to iron limitation and oxidative damage to the  iron-sulfur cluster,        and many microorganisms induced flavodoxin expression to replace  ferredoxin        under stress conditions. Paradoxically, ferredoxin was maintained  throughout        the tree of life, whereas flavodoxin is absent from plants and animals.        Noteworthy, flavodoxin expression in transgenic plants results in  increased        tolerance to multiple stresses and iron deficit, through mechanisms  similar to        those operating in microorganisms. Then, the question remains open as to  why        a trait which still confers plants so obvious adaptive benefits was not  retained.        We compare herein the properties of ferredoxin and flavodoxin, and their        contrasting modes of expression in response to different environmental  stimuli.        Phylogenetic analyses suggest that the flavodoxin gene was already  absent in        the algal lineages immediately preceding land plants. Geographical  distribution        of phototrophs shows a bias against flavodoxin-containing organisms in  iron        rich coastal\/freshwater habitats. Based on these observations, we  propose that        &nbsp;plants evolved from freshwater macroalgae which already lacked  flavodoxin        &nbsp;because they thrived in an iron-rich habitat with no need to back up  ferredoxin        &nbsp;functions and therefore, no selective pressure to keep the flavodoxin  gene.        &nbsp;Conversely, ferredoxin retention in the plant lineage is likely related  to its higher        &nbsp;efficiency as electron carrier compared to flavodoxin. Several lines of  evidence        &nbsp;supporting  these contentions are presented and discussed.  ","palabras_clave":"ELECTRON TRANSFER|ENVIRONMENTAL STRESS|EVOLUTION|FLAVODOXIN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40062,"idioma_id":4,"titulo":"Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases.","resumen":"Bone is the most common site of prostate cancer (PCa) progression to a therapy-resistant, lethal phenotype. We found that blockade of fibroblast growth factor receptors (FGFRs) with the receptor tyrosine kinase inhibitor dovitinib has clinical activity in a subset of men with castration-resistant PCa and bone metastases. Our integrated analyses suggest that FGF signaling mediates a positive feedback loop between PCa cells and bone cells and that blockade of FGFR1 in osteoblasts partially mediates the antitumor activity of dovitinib by improving bone quality and by blocking PCa cell-bone cell interaction. These findings account for clinical observations such as reductions in lesion size and intensity on bone scans, lymph node size, and tumor-specific symptoms without proportional declines in serum prostate-specific antigen concentration. Our findings suggest that targeting FGFR has therapeutic activity in advanced PCa and provide direction for the development of therapies with FGFR inhibitors.","palabras_clave":"Prostate Cancer|Bone Metastases|FGFR1"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40063,"idioma_id":4,"titulo":"Use of cheese whey for biomass production and spray drying of probiotic lactobacilli","resumen":"The double use of cheese whey (culture medium and thermoprotectant for spray drying of lactobacilli) was explored in this study for adding value to this wastewater. In-house formulated broth (similar to MRS) and dairy media (cheese and ricotta whey and whey permeate) were assessed for their capacity to produce biomass of Lactobacillus paracasei JP1, Lb. rhamnosus 64 and Lb. gasseri 37. Simultaneously, spray drying of cheese whey-starch solution (without lactobacilli cells) was optimised using surface response methodology. Cell suspensions of the lactobacilli, produced in in house-formulated broth, were spray-dried in cheese whey-starch solution and viability monitored throughout the storage of powders for 2 months. Lb. rhamnosus 64 was able to grow satisfactorily in at least two of the in-house formulated culture media and in the dairy media assessed. It also performed well in spray drying. The performance of the other strains was less satisfactory. The growth capacity, the resistance to spray drying in cheese whey-starch solution and the negligible lost in viability during the storage (2 months), makes Lb. rhamnosus 64 a promising candidate for further technological studies for developing a probiotic dehydrated culture for foods, utilising wastewaters of the dairy industry (as growth substrate and protectant) and spray drying (a low-cost widely-available technology).","palabras_clave":"CHEESE WHEY|WHEY PERMEATE|RICOTTA WHEY|BIOMASS|PROBIOTICS|SPRAY DRYING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40064,"idioma_id":4,"titulo":"Physico-chemical characterization of ferrocenyl-modified hyperbranched poly(ethylenimine) self-assembled multilayers","resumen":"AbstractIn this work, we characterize the electrochemical behavior of a new ferrocenyl-modified, hyperbranched poly(ethylenimine) (HBPei-Fc). The effects of the ionic strength, pH and the nature of the anion of the supporting electrolyte on the electrochemical behavior of the redox polymer were studied using cyclic voltammetry and an electrochemical quartz crystal microbalance. The interactions of the polymer with the anions of the supporting electrolyte, which was incorporated during the redox process, determined the electrochemical behavior that was observed. The polymer was employed for the construction of layer-by-layer-assembled multi-composite films using thiolated gold surfaces with HBPei-Fc as the polycation and citrate-stabilized gold nanoparticles or glucose oxidase (GOx) as the negative polyelectrolyte. The self-assembled multilayers were characterized using UV-Vis spectrophotometry and electrochemical techniques to follow the signal of the ferrocene groups of the polymer. The adsorption of the polymer and GOx was analyzed using surface plasmon resonance to determine the surface coverage and the kinetic properties of the process. The results demonstrated that the ferrocenyl-modified polymer is an efficient platform for the immobilization of both inorganic materials, such as metallic nanoparticles, and biomolecules. © 2013 Elsevier B.V. All rights reserved.","palabras_clave":"Physico-chemical characterization|ferrocenyl-modified hyperbranched poly(ethylenimine) | self-assembled multilayers"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40065,"idioma_id":4,"titulo":"Bioelectrochemical sensing of promethazine with bamboo-type multiwalled carbon nanotubes dispersed in calf-thymus double stranded DNA","resumen":"We report the quantification of promethazine (PMZ) using glassy carbon electrodes (GCE) modified with bamboo-like multi-walled carbon nanotubes (bCNT) dispersed in double stranded calf-thymus DNA (dsDNA) (GCE\/bCNT- dsDNA). Cyclic voltammetry measurements demonstrated that PMZ presents a thin film-confined redox behavior at GCE\/bCNT-dsDNA, opposite to the irreversibly-adsorbed behavior obtained at GCE modified with bCNT dispersed in ethanol (GCE\/bCNT). Differential pulse voltammetry-adsorptive stripping with medium exchange experiments performed with GCE\/bCNT-dsDNA and GCE modified with bCNTs dispersed in single-stranded calf-thymus DNA (ssDNA) confirmed that the interaction between PMZ and bCNT-dsDNA is mainly hydrophobic. These differences are due to the intercalation of PMZ within the dsDNA that supports the bCNTs, as evidenced from the bathochromic displacement of UV-Vis absorption spectra of PMZ and quantum dynamics calculations at DFTB level. The efficient accumulation of PMZ at GCE\/bCNT- dsDNA made possible its sensitive quantification at nanomolar levels (sensitivity: (3.50 &#61617; 0.05) x108 &#61549;A.cm-2.M-1 and detection limit: 23 nM). The biosensor was successfully used for the determination of PMZ in a pharmaceutical product with excellent correlation.","palabras_clave":"DNA| bamboo-type multiwalled carbon nanotubes | promethazine |Bioelectrochemical sensing"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40066,"idioma_id":4,"titulo":"The equine arteritis virus isolate from the 2010 Argentine outbreak","resumen":"A semen sample from a stallion infected during the 2010 equine arteritis virus (EAV) outbreak was received for viral isolation prior to castration. EAV was identified using an immunofluorescence test, using polyclonal antibodies. RT-PCR to amplify a region of the GP5 gene was performed with primers GL105F and GL673R. The PCR products were purified and sequences of both strands were determined in a MegaBACE TM 1000 with inner primers CR2 and EAV32. The phylogenetic dataset was built with the five strains isolated in Argentina and the sequences reported previously and a group of selected sequences obtained from GenBank. The unrooted neighbor-joining tree was constructed using MEGA and bootstrap analyses were conducted using 1000 replicate datasets. The evolutionary distances were computed using the Maximum Composite Likelihood method. To predict N-glycosylation in GP5 sequences, the NetNGlyc Server analysis by Technical University of Denmark (http:\/\/www.cbs.dtu.dk\/services\/NetNGlyc\/) was performed. The phylogenetic analysis revealed that, together with other strains previously isolated in our laboratory, the new strain (named GLD-LP-ARG) belongs to the European group EU-1 but another branch. The new strain had 99% of nucleotide identity with strain A1 and 98.1% with the Belgian strain 08P178. The persistently infected stallions and their cryopreserved semen constitute the reservoir of EAV, which ensures its persistence in the horse population around the world. These findings reinforce the importance of carefully monitoring EAV persistent infected stallions, as well as semen straws, by RT-PCR or Test mating, according to National regulations.","palabras_clave":"Arteritis|Argentina|outbreak"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40067,"idioma_id":4,"titulo":"Susceptibility of chickens (Gallus gallus domesticus) to Trichinella patagoniensis","resumen":"Trichinella spp is a genus of parasites that is widespread all over the world. In Argentina, T. spiralis was for years the only species involved in human and animal outbreaks. During the last decade, T. patagoniensis, a new Trichinella species was discovered in Argentina. Up to now, this species has only been found in cougars (Puma concolor). Experimental infections in pigs, cats, mice and rats with this new genotype showed that cats and mice were the most susceptible hosts. The aim of the present work was to evaluate the susceptibility of chickens to infection with T. patagoniensis. In order to study the intestinal and muscular phase, and the histopathological changes, 27 Leghorn chickens were inoculated per os with 1000 muscle larvae of T. patagoniensis and were euthanized on days 4, 5, 6, 7, 11, 14, 21, 28 and 35. Adult worms of T. patagoniensis were recovered from the small intestine of chickens up to day 14 p.i. Gross examination of small intestine showed a moderate congestive appearance. Microscopically, an inflammatory response with lymphocytes and eosinophils in lamina propria, slight hyperemia, oedema and some hemorrhagic areas were detected. Lesions observed in chickens were similar to those described in different animal species during the intestinal phase. No muscular larvae were recovered from the muscle samples. These results suggest that T. patagoniensis is not capable to complete its entire life cycle in chickens.","palabras_clave":"Trichinella patagoniensis|Chicken|Histopathology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40068,"idioma_id":4,"titulo":"Epidemiological Description of Cystic Ovarian Disease in Argentine Dairy Herds: Risk Factors and Effects on the Reproductive Performance of Lactating Cows","resumen":"XXX","palabras_clave":"COD|INCIDENCE |BOVINE|RISK"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40069,"idioma_id":5,"titulo":"Factores asociados con la presentación de  accidentes laborales en veterinarios zootecnistas  del departamento de Boyacá (Colombia)","resumen":"Objetivo: Cuantificar los Accidentes Laborales (AL) e identificar los factores asociados a su presentación en veterinarios zootecnistas del departamento de Boyacá.  Materiales y métodos: Este es un estudio observacional de tipo transversal que permitió cuantificar los accidentes laborales (AL) en médicos veterinarios zootecnistas (MVZ) con matrícula profesional vigente y ejercicio profesional en el departamento de Boyacá. Se calculó el tamaño muestral (n), con una frecuencia estimada de accidentes del 75 %, un error absoluto del 5 % y un nivel de confianza del 95 %, ajustándolo por el tamaño de la población (N). El diseño muestral fue aleatorio simple. El análisis estadístico incluyó correlación de Spearman, X2 y regresión logística. Los análisis se efectuaron con SPSS®.  Resultados: El promedio de edad fue de 33,8±8,2 años. El 91,7 % de los encuestados tuvo por los menos un AL que involucró la presencia de animales, agujas, bisturí y\/o un medio de movilización al lugar de trabajo. Las lesiones más frecuentes producto de los AL fueron:  heridas punzantes y cortantes, contusiones, hematomas, reacciones alérgicas. Los hombres presentaron 3,086 veces más probabilidades de sufrir este tipo de accidentes que las mujeres (p=0,017). El trabajo con grandes animales es la especialidad veterinaria a la cual se dedicaba  la mayor proporción (67,1 %) de encuestados. En el trabajo con pequeños animales, los accidentes de mayor presentación fueron: atropellamiento por animales, punzada, corte, mordedura, esfuerzo físico y caída\/resbalón.  Conclusiones: Los resultados obtenidos condicionan y procuran revaluar aspectos ocupacionales en aras de minimizar los riesgos en la actividad rural de Boyacá.","palabras_clave":"ACCIDENTE|RIESGOS LABORALES|RURAL|VETERINARIOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40070,"idioma_id":4,"titulo":"ACCIDENTS IN FARMING IN SANTA FE PROVINCE, ARGENTINA","resumen":"Background: the Background: frequency of occupational accidents tends to be high in rural areas. Objectives: Objectives: to Objectives: characterize accidents and injuries, risk perception and adoption of protective elements on livestock workers in Sarmiento, Santa Fe, Argentina. Methods: Methods: a Methods: cross-sectional study was carried out on a random sample of 125 workers. Data was collected by personal interviews using a structured questionnaire. Statistical  analysis included &#967;2, Spearman rank correlation and logistic regression. Results: Results fifty four percent had suffered at least one occupational accident, being associated with sex (P= 0.04), activity within the farm  (P= 0.18) and years of farm work (P= 0.02). Perceptions of risk were highest in itinere traffic (92%) and handling of chemicals (85%) but was not correlated with the adoption of safety practices. Correlations between perceptions were highest between the use of machinery and tools (r= 0.83, P< 0.0001) and the  handling of abortions and carcasses (r= 0.71, P< 0.0001). Wearing gloves was most frequent when handling abortions (61%) and was correlated with their use during parturitions and the handling of carcasses (r= 0.92 and 0.94 respectively, P< 0.0001). Seat belts and car lights during daytime were mostly  used on main roads. Conclusions: Conclusions an intensive educational effort is suggested to minimize the frequency of accidents and maximize the adoption of safety practices","palabras_clave":"ACCIDENTES|PROTECTIVE ELEMENTS|LIVESTOCK PRODUCTION|RISK PERCEPTION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40071,"idioma_id":4,"titulo":"The Conditions of Ovary Storage Affect the Quality of Porcine Oocytes","resumen":"We studied the effect of different storage conditions of porcine ovaries (time, temperature) on the characteristics of the follicular fluid, immature oocyte quality, meiotic competence and fertilization of oocytes. Ovaries were stored for 2, 4 or 6 h at 3 different temperatures (15, 25 or 35°C). As the storage time increased, pH and glucose concentration of the follicular fluid, percentage of live immature oocytes at germinal vesicle stage, oxidative activity and maturation rate decreased. At higher temperatures, pH and glucose concentration decreased, but oxidative activity and oocyte maturation rate increased. Lactate concentration and immature oocyte ROS production increased as storage time and temperature increased. The ovary storage for longer than 2 h at 25 and 35°C resulted in low pH of the follicular fluid and high ROS level in immature oocytes. Such conditions seem to damage oocytes and impair their meiotic competence. A decrease in the oxidative activity caused by long time and\/or low storage temperature may imply a decrease in oocyte vitality. In conclusion, in the porcine species, the transport of ovaries at 25 and 35°C for 2 h are the best conditions to maintain adequate oocyte quality, meiotic competence and fertilization rates.","palabras_clave":"Ovary storage|Oocyte quality|Pig"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40072,"idioma_id":4,"titulo":"Protective Effects of Intranasal Immunization with Recombinant Glycoprotein D in Pregnant  BALB\/c Mice Challenged with Different Strains of Equine Herpesvirus 1","resumen":"Equine herpesvirus (EHV)-1 induces respiratory infection, neurological disorders and abortion in horses.  Most of the currently available attenuated or inactivated vaccines against this infection are administered intramuscularly and only provide partial protection against the respiratory disease.  The present study examines the effect of intranasal immunization with purified EHV-1 recombinant glycoprotein D (gD) in BALB\/c mice followed by challenge with three different EHV-1 strains during early to mid-pregnancy.  The induced viral infection was evaluated by virus isolation, DNA detection by polymerase chain reaction, histopathology and immunohistochemical localization of antigen in the lung, placenta and uterus.  Non-immunized mice showed clinical signs of infection, positive virus isolation from lungs and uteri, and abortion induced by one of the virus strains. Endometrial lesions developed in some of these animals that have been described previously only in horses.  Immunized mice and their offspring had no viral infection or typical lesions.  Intranasally administered gD therefore induced partial or complete protection against three different EHV-1 strains in BALB\/c mice.","palabras_clave":"Equine herpesvirus 1|Glycoprotein D| Intranasal inoculation|Mouse abortion model"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40073,"idioma_id":4,"titulo":"Phage adsorption on Enteropathogenic and Shiga Toxin-Producing Escherichia coli strains: influence of physicochemical and physiological factors","resumen":"Bacteriophages have proved to be useful tools against pathogenic Escherichia coli strains. The first step in the phage life cycle is the adsorption to the host cell surface. In the present work, three Myoviridae phages (DT1, DT5 and DT6) were used to characterize the adsorption process on three pathogenic E. coli strains, namely two Shiga-toxin producing E. coli (STEC) and one enteropathogenic E. coli (EPEC), in several conditions found on food. The influence of Na+, Mg2+, temperature, pH, periodate, proteinase K and physiological cell state on phage adsorption was investigated. The three phages evaluated showed high adsorption rates at pH 7.5 and 5.7 while they were moderate at the lowest pH evaluated (4.5). Sodiumor magnesiumions were not indispensable for the adsorption of the three phages evaluated. Specifically, phage particles were adsorbed either in the presence or absence of Mg2+, while increasing Na+ concentration resulted in lower adsorption values for allthe systems evaluated. Regarding temperature, phage adsorption was slightly affected at 4 °C and 50 °C, while it reached its maximum at 37 °C. Adsorption rates decreased after the thermal inactivation of cells, though, when chloramphenicol (as protein-synthesis inhibitor) was used, adsorption values on treated and untreated cells were similar. In addition, periodate was able to decrease phage adsorption, thus suggesting the receptors were carbohydrates in nature. All these results showed that the adsorption process was only partially affected and most conditions are suitable for the completion of the first step in the phage life cycle. Therefore, phages evaluated in this study can be used to prevent foodborne diseases on several food matrices since they are activein a wide range of environmental conditions.","palabras_clave":"ESCHERICHIA COLI|BACTERIOPHAGE|ADSORPTION|RECEPTOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40074,"idioma_id":4,"titulo":"'Wild-type minimal inhibitory concentration distributions in bacteria of animal origin in Argentina'","resumen":"The aim of this study was to determine the antimicrobial resistance profiles of indicator bacteria isolated from domestic animal feces. Minimal inhibitory concentration (MIC) was determined by agar dilution. Interpretative criteria on the basis of wild-type MIC distributions and epidemiological cutoff values (ECOFF or ECV) were used according to the ´European Committee on Antimicrobial Susceptibility Testing´ (EUCAST) data. Results from 237 isolates of Escherichia coli showed reduced susceptibility for ampicillin, streptomycin and tetracycline, the antimicrobials commonly used in intensive breeding of pigs and hens. Regarding all the species of the genus Enterococcus spp., there are only ECOFF or ECV for vancomycin. Of the 173 Enterococcus spp. isolated, only one showed reduced susceptibility to vancomycin and was classified as ´non-wild-type´ (NWT) population. This is the first report in Argentina showing data of epidemiological cutoff values in animal bacteria.","palabras_clave":"Escherichia coli|Enterococcus|Monitoreo|Resistencia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40075,"idioma_id":4,"titulo":"HELICOBACTER  PYLORI  AND ORAL PATHOLOGY: RELATIONSHIP WITH THE GASTRIC INFECTION","resumen":"Helicobacter pylori (H. pylori) has been found in the oral cavity and stomach, and its infection is one of the most frequent worldwide. We reviewed the literature and conducted a Topic Highlight, which identified studies reporting an association between H. pylori-infection in the oral cavity and H. pylori-positive stomach bacterium. This work was designed to determine whether H. pylori is the etiologic agent in periodontal disease, recurrent aphthous stomatitis (RAS), squamous cell carcinoma, burning and halitosis. Record selection focused on the highest quality studies and meta-analyses. We selected 48 articles reporting on the association between saliva and plaque and H. pylori-infection. In order to assess periodontal disease data, we included 12 clinical trials and 1 meta-analysis. We evaluated 13 published articles that addressed the potential association with RAS, and 6 with squamous cell carcinoma. Fourteen publications focused on our questions on burning and halitosis. There is a close relation between H. pylori infection in the oral cavity and the stomach. The mouth is the first extra-gastric reservoir. Regarding the role of H. pylori in the etiology of squamous cell carcinoma, no evidence is still available.","palabras_clave":"HELICOBACTER pylori|Oral pathology|Gastric infection|Burning and halitosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40076,"idioma_id":4,"titulo":"The Pan-Caspase Inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis","resumen":"Background and Aims:   Hepatocyte apoptosis, the hallmark of non-alcoholic steatohepatitis (NASH) contributes to liver injury and fibrosis. Although, both the intrinsic and extrinsic apoptotic pathways are involved in the pathogenesis of NASH, the final common step of apoptosis is executed by a family of cysteine-proteases termed caspases. Thus, our aim was to ascertain if administration of Emricasan, a pan-caspase inhibitor, ameliorates liver injury and fibrosis in a murine model of NASH.  METHODS:  C57\/BL6J-mice were fed regular chow or high fat diet (HFD) for 20 weeks. All mice were treated with vehicle or Emricasan.  RESULTS:  Mice fed a HFD diet demonstrate a five-fold increase in hepatocyte apoptosis by the TUNEL assay and a 1.5-fold and 1.3-fold increase in caspase-3 and-8 activities respectively; this increase in apoptosis was substantially attenuated in mice fed a HFD treated with Emricasan (HFD-Em). Likewise, liver injury and inflammation were reduced in mice fed HFD-Em as compare to HFD by measuring serum aspartate aminotransferase and alanine aminotransferase levels, NAS histological score and IL 1-&#946;, TNF-&#945;, monocyte chemoattractant protein (MCP-1) and C-X-C chemokine ligand-2 (CXCL2) quantitative reverse-transcription polymerase chain reaction (qPCR). These differences could not be attributed to differences in hepatic steatosis as liver triglycerides content were similar in both HFD groups. Hepatic fibrosis was reduced by Emricasan in HFD animals by decreasing &#945;SMA (a marker for hepatic stellate cell activation), fibrosis score, Sirius red staining, hydroxyproline liver content and profibrogenic cytokines by qPCR.  CONCLUSION:  In conclusion, these data demonstrate that in a murine model of NASH, liver injury and fibrosis are suppressed by inhibiting hepatocytes apoptosis and suggests that Emricasan may be an attractive antifibrotic therapy in NASH.","palabras_clave":"Liver|gastroenterology|non-alcoholic steatohepatitis.|caspases"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40077,"idioma_id":4,"titulo":"Molecular pathology of acute kidney injury in a choline-deficient model and fish oil protective effect","resumen":"Purpose The aim of this work was to investigate the potential protective effects of fish oil on the basis of kidney transcriptomic data on a nutritional experimental model. Methods Male weanling Wistar rats were divided into four groups and fed choline-deficient (CD) and choline-supplemented (CS) diets with vegetable oil (VO) and menhaden oil (MO): CSVO, CDVO, CSMO and CDMO. Animals were killed after receiving the diets for 6 days. Total RNA was purified from the right kidney and hybridized to Affymetrix GeneChip Rat Gene 1.0 ST Array. Differentially expressed genes were analyzed. Results All CSVO, CSMO and CDMO rats showed no renal alterations, while all CDVO rats showed renal cortical necrosis. A thorough analysis of the differential expression between groups CSMO and CDMO was carried out. There were no differential genes for p&#65533;.01. The  analysis of the differential expression between groups CSVO and CSMO revealed 32 genes, 11 were overexpressed and 21 were under-expressed in CSMO rats. Conclusions Thiswork was part of a large set of experiments  and was used in a hypothesis-generating manner. The comprehensive  analysis of genetic expression allowed confirming that menhaden oil has a protective effect on this nutritional experimental model and identifying 32 genes that could be responsible for that protection, including Gstp1. These results reveal that gene changes could play a role in renal injury.","palabras_clave":"Acute kidney injury |Choline-deficient |Gene expression|Menhaden oil"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40078,"idioma_id":4,"titulo":"Clinical outcome and vertical transmission variability among canine Neospora caninum isolates in a pregnant mouse model of infection","resumen":"We compared the clinical outcome and vertical transmission of six canine isolates using a pregnant BALB\/c model. Four of the isolates were obtained from oocysts of naturally infected dogs (Nc-Ger2, Nc-Ger3, Nc-Ger6 and Nc-6Arg) and two of them were from dogs with neurological signs (Nc-Bahia and Nc-Liv). The dams were inoculated with 2x106 tachyzoites of each isolate at day 7 of pregnancy. Morbidity, mortality and the humoral immune response were evaluated in both the dams and the offspring, as was parasite transmission to the progeny. The mortality rates varied from 100% in Nc-Bahia and Nc-Liv-infected pup to less than 19% for those infected with the isolates obtained from oocysts. The vertical transmission rates varied from 9% to 53% for N. caninum from oocysts, compared to 100% for the Nc-Liv and Nc-Bahia isolates. All the dams showed specific IgG responses against tachyzoite and rNc-GRA7 antigens, confirming N. caninum infection. The highest IgG levels were detected in mice infected with the Nc-Liv and Nc-Bahia isolates. These results demonstrate marked differences between N. caninum isolates obtained from oocysts and neurologically affected dogs. The variability observed could help us to explain the differences in the outcome of the infection in definitive and intermediate hosts.","palabras_clave":"NEOSPORA CANINUM|CANINE ISOLATES|VIRULENCE|VERTICAL TRANSMISSION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40079,"idioma_id":4,"titulo":"Solution and crystal structure of BA42, a protein from the Antarctic bacterium  Bizionia argentinensis comprised of a stand-alone TPM domain","resumen":"    The structure of the  BA42 protein belonging to the Antarctic flavobacterium Bizionia argentinensis was determined by Nuclear Magnetic Resonance  and X-ray crystallography. This is the first structure of a member of the  PF04536 family comprised of a stand-alone TPM domain. The structure reveals a  new topological variant of the four &#946;-strands constituting the central b-sheet of the aba architecture and a double metal  binding site stabilizing a pair of crossing loops, not observed in previous  structures of proteins belonging to this family. BA42 shows differences in structure  and dynamics in the presence or absence of bound metals. The affinity for  divalent metal ions is close to that observed in proteins that modulate their  activity as a function of metal concentration, anticipating a possible role for  BA42.  ","palabras_clave":"STRUCTURAL GENOMICS|ANTARCTIC BACTERIA|BIZIONIA ARGENTINENSIS|BA42|PROTEIN STRUCTURE|NUCLEAR MAGNETIC RESONANCE|X-RAY CHRYSTALLOGRAPHY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40080,"idioma_id":4,"titulo":"Thermodynamic gradient-based poroplastic theory for concrete under high temperatures","resumen":"Concrete materials subjected to long term exposures to high temperatures suffer severe degradations in its mechanical properties (cohesion, strength and stiffness)and changes in their failure mechanisms. These degradations may lead to irreversible damage or sudden collapse of the related structures. From the predictive analysis stand point, accurate constitutive theories are required to simulate the variations of concrete mechanical failure behavior under high and durable temperature fields. In he realm of the smeared crack approach, non-local model strategies are required to objectively reproduce failure behaviors under coupled thermo-mechanical loading conditions, while realistic descriptions of the involved characteristic lengths are needed to objectively reproduce the variation from ductile to brittle failure modes depending on the acting confining pressure and temperature. In this work,a thermodynamically consistent gradient poroplastic model for concrete subjected to high temperatures is proposed. A particular and simple form of gradient-based poroplasticity is considered whereby the state variables are the only ones of non-local character. The degradations of these variables due to coupled thermo-mechanical effects are described in the framework of the thermodynamic approach. After describing the material formulation, numerical analyses are presented which demonstrate the predictive capabilities of the proposed constitutive theory for different stress paths and thermal conditions.","palabras_clave":"CONCRETE|THERMODYNAMIC CONSISTENCY|GRADIENT THEORY|HIGH TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40081,"idioma_id":4,"titulo":"DISCONTINUOUS BIFURCATION ANALYSIS OF THERMODYNAMICALLY CONSISTENT GRADIENT POROPLASTIC MATERIALS","resumen":"In this work, analytical and numerical solutions of the condition for discontinuous bifurcation of thermodynamically consistent gradient-based poroplastic materials are obtained and evaluated. The main aim is the analysis of the potentials for localized failure modes in the form of discontinuous bifurcation in partially saturated gradient-based poroplastic materials as well as the dependence of these potentials on the current hydraulic and stress conditions. Also the main differences with the localization conditions of the related local theory for poroplastic materials are evaluated to perfectly understand the regularization capabilities of the non-local gradient-based one. Firstly, the condition for discontinuous bifurcation is formulated from wave propagation analyses in poroplastic media. The material formulation employed in this work for the spectral properties evaluation of the discontinuous bifurcation condition is the thermodynamically consistent, gradient-based modified Cam Clay model for partially saturated porous media previously proposed by the authors. The main and novel feature of this constitutive theory is the inclusion of a gradient internal length of the porous phase which, together with the characteristic length of the solid skeleton, comprehensively defined the non-local characteristics of the represented porous material. After presenting the fundamental equations of the thermodynamically consistent gradient based poroplastic constitutive model, the analytical expressions of the critical hardening\/softening modulus for discontinuous bifurcation under both drained and undrained conditions are obtained. As a particular case, the related local constitutive model is also evaluated from the discontinuous bifurcation condition stand point. Then, the localization analysis of the thermodynamically consistent non-local and local poroplastic Cam Clay theories is performed. The results demonstrate, on the one hand and related to the local poroplastic material, the decisive role of the pore pressure and of the volumetric non-associativity degree on the location of the transition point between ductile and brittle failure regimes in the stress space. On the other hand, the results demonstrate as well the regularization capabilities of the non-local gradientbased poroplastic theory, with exception of a particular stress condition which is also evaluated in this work. Finally, it is also shown that, due to dependence of the characteristic lengths for the pore and skeleton phases on the hydraulic and stress conditions, the non-local theory is able to reproduce the strong reduction of failure diffusion that takes place under both, low confinement and low pore pressure of partially saturated porous materials, without loosing, however, the ellipticity of the related differential equations.","palabras_clave":"GRADIENT THEORY|POROUS MEDIA|LOCALIZED FAILURE|SOFTENING BEHAVIOR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40082,"idioma_id":4,"titulo":"-\tInfluence of antibodies transferred by colostrum in the immune responses of calves to current foot-and-mouth disease vaccines","resumen":"Immunity to currently used oil-adjuvanted inactivated vaccines against foot-and-mouth disease virus (FMDV) has been studied in detail in adult animals; however, the influence of maternally derived antibodies transferred through colostrum (Mat-Abs) in the immune responses of vaccinated calves is less clear. Here, we report the anti-FMDV humoral responses elicited in calves with or without Mat-Abs that received one or two doses of the current tetravalent oil-adjuvanted commercial vaccine used in Argentina. Anti-FMDV (O1\/Campos strain) antibodies (Abs) were evaluated by Liquid Phase Blocking ELISA (LPB-ELISA), virus neutralization test (VNT), isotype ELISA (IgG1, IgG2 and IgM) and avidity ELISA, to allow for the first time a more detailed description of the humoral responses elicited. Our results show that primary IgM responses to FMDV vaccination only became evident as Mat-Abs titers decreased. Likewise, prime and boost vaccination schedules, applied 35 days apart to groups of calves with high or low levels of Mat-Abs, showed that the levels of preexisting neutralizing Mat-Abs prevented the loss of total Abs measured by LPB-ELISA but negatively interfered with the induction of virus neutralizing responses. Altogether, these findings indicate that comprehensive serological characterization of immune responses generated after vaccination in calves may reveal important information on the actual effectiveness of vaccination strategies for young animals, particularly in endemic settings.","palabras_clave":"Foot-and-mouth disease vaccines|Colostral immunity|Maternal antibodies|Calves|Serology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40083,"idioma_id":4,"titulo":"Lipopolysaccharides and trophic factors regulate the LPS receptor complex in nodose and trigeminal neurons","resumen":"Binding of bacterial Lipopolisaccharydes (LPS) to Toll-like receptor 4 (TLR4) triggers  an innate immunoresponse associated to pain and inflammation. The expression and  regulation of the TLR4 and its auxiliary proteins are poorly understood in trigeminal and  nodose neurons.  We used a combination of Western Blot, semi-quantitative PCR, pharmacological  manipulation and immunostaining to determine the expression pattern and regulation  by LPS and trophic factors of TLR4\/MD2\/CD14 and RP105\/MD1 in neonatal trigeminal  and nodose mice neurons. We found that all these proteins were expressed in both  trigeminal and nodose neurons. We demonstrated that the trophic factors Artemin and  NGF upregulated MD2 and RP105 mRNA levels in trigeminal neurons, while CNTF,  LIF and BDNF upregulated MD1 and also RP105 mRNA levels in nodose neurons.  LPS acutely (within 20 mins) down regulated CD14 and MD2, but their mRNA levels  recovered after 3 hrs. In addition, LPS increased significantly the proportion of  Nociceptin\/Orphanin FQ neurons in both trigeminal and nodose neurons in culture via  TLR4\/MD2.  We conclude that LPS acts through its archetypical receptor in trigeminal and nodose  neurons. In turn these receptor complexes are acutely regulated by LPS. Trophic  factors also have a regulatory influence in the longer term. Thus, in sensory nodose  and trigeminal neurons LPS may stimulate TLR4\/MD2\/CD14 and\/or RP105\/MD1  resulting in the common symptoms provoked by gram negative bacterial infections  (e.g. fiber inflammation, pain, cough, toothache).","palabras_clave":"LIPOPOLYSACHARIDES|LPS RECEPTOR|NODOSE AND TRIGEMINAL NEURONS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40084,"idioma_id":4,"titulo":"Targeting PI3K\/mTOR overcomes resistance to HER2-targeted therapy independent of feedback activation of AKT","resumen":"Clin Cancer Res. 2014 Jul 1;20(13):3507-20. doi: 10.1158\/1078-0432.CCR-13-2769. Epub 2014 May 30.Targeting PI3K\/mTOR overcomes resistance to HER2-targeted therapy independent of feedback activation of AKT.O'Brien NA1, McDonald K2, Tong L2, von Euw E2, Kalous O2, Conklin D2, Hurvitz SA2, di Tomaso E3, Schnell C4, Linnartz R3, Finn RS2, Hirawat S3, Slamon DJ2.Author informationAbstractPURPOSE:Altered PI3K\/mTOR signaling is implicated in the pathogenesis of a number of breast cancers, including those resistant to hormonal and HER2-targeted therapies.EXPERIMENTAL DESIGN:The activity of four classes of PI3K\/mTOR inhibitory molecules, including a pan-PI3K inhibitor (NVP-BKM120), a p110&#945; isoform-specific PI3K inhibitor (NVP-BYL719), an mTORC1-specific inhibitor (NVP-RAD001), and a dual PI3K\/mTORC1\/2 inhibitor (NVP-BEZ235), was evaluated both in vitro and in vivo against a panel of 48 human breast cell lines.RESULTS:Each agent showed significant antiproliferative activity in vitro, particularly in luminal estrogen receptor-positive and\/or HER2(+) cell lines harboring PI3K mutations. In addition, monotherapy with each of the four inhibitors led to significant inhibition of in vivo growth in HER2(+) breast cancer models. The PI3K\/mTOR pathway inhibitors were also effective in overcoming both de novo and acquired trastuzumab resistance in vitro and in vivo. Furthermore, combined targeting of HER2 and PI3K\/mTOR leads to increased apoptosis in vitro and induction of tumor regression in trastuzumab-resistant xenograft models. Finally, as previously shown, targeting mTORC1 alone with RAD001 leads to consistent feedback activation of AKT both in vitro and in vivo, whereas the dual mTOR1-2\/PI3K inhibitor BEZ235 eliminates this feedback loop. However, despite these important signaling differences, both molecules are equally effective in inhibiting tumor cell proliferation both in vitro and in vivo.CONCLUSION:These preclinical data support the findings of the BOLERO 3 trial that shows that targeting of the PI3K\/mTOR pathway in combination with trastuzumab is beneficial in trastuzumab-resistant breast cancer.©2014 American Association for Cancer Research.","palabras_clave":"PI3K\/mTOR |HER2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40085,"idioma_id":4,"titulo":"Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity  in ovarian hyperstimulation syndrome (OHSS).","resumen":"Ovarian hyperstimulation syndrome (OHSS) is a complication of ovarian stimulation with gonadotrophins  following human chorionic gonadotrophin (hCG) administration. The relationship between hCG and OHSS is partly  mediated via the production of angiogenic factors, such as vascular endothelial growth factor A (VEGFA) and  angiopoietins (ANGPTs). Here, we investigated the effect of ANGPT1 inhibition on ovarian angiogenesis in follicular  fluid (FF) from women at risk of OHSS, using the chorioallantoic membrane (CAM) of quail embryos as an experimental  model. We also analysed cytoskeletal changes and endothelial junction protein expression induced by this FF in the  presence or absence of an ANGPT1-neutralising antibody in endothelial cell cultures. The presence of this antibody  restored the number of vascular branch points and integrin avb3 levels in the CAMs to control values. ANGPT1 inhibition  in FF from OHSS patients also restored the levels of claudin-5, vascular endothelial cadherin and phosphorylated  b-catenin and partially reversed actin redistribution in endothelial cells. Our findings suggest that ANGPT1 increases  pathophysiological angiogenesis in patients at risk of OHSS by acting on tight and adherens junction proteins. Elucidating  the mechanisms by which ANGPT1 regulates vascular development and cell?cell junctions in OHSS will contribute to  identifying new therapeutic targets for the treatment of human diseases with aberrant vascular leakage","palabras_clave":"angiogenesis|follicular fluid|ovary|reproduction"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40086,"idioma_id":5,"titulo":"Practicas y saberes del personal afectado al comedor del Hogar Maternal Nº 1, de la ciudad de Rosario","resumen":"Está demostrada la relación existente entre una inadecuada manipulación de los alimentos y la producción de enfermedades trasmitidas a través de éstos3. En el campo de la salud pública, los comedores de centros escolares presentan una especial importancia por ser utilizados por un grupo de población tipificado como colectivo vulnerable1. La asistencia alimentaria a escolares en nuestro país se remonta al año 1914 en el que se incluye por primera vez en el presupuesto del Consejo Nacional de Educación, una partida anual para la alimentación de algunas escuelas de Capital Federal y territorios nacionales2. Las Buenas Prácticas de Manufactura (BPM) son una herramienta que contribuye al fortalecimiento de la calidad en la producción de alimentos que sean seguros, saludables, e inocuos para el consumo humano. El manipulador de alimentos es aquella persona que por su actividad laboral, tiene contacto directo o indirecto con los alimentos durante su preparación, transformación, procesado, elaboración, envasado, almacenamiento, transporte, venta, suministro y servicio.","palabras_clave":"PRACTICAS Y SABERES|MANIPULADORA|COMEDOR|ESCOLAR"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40087,"idioma_id":4,"titulo":"Mouse colorectal cancer an early detection approach using nonlinear microscopy","resumen":"Murine induced colon cancer has been used to demonstrate that Second Harmonic Generation (SHG) microscopy images, combined with Two-Photon Excitation Fluorescence (TPEF) and specific quantization scoring methods allow distinguishing early alterations in colon mucosa. TPEF was used only to identified crypts and submucosa regions, whereas the image analysis was used to get quantitative data (Integrated Intensity and Aspect Ratio scoring) of different cancer stages. The submucosa amount of collagen fibers was significant and their orientation suffering proportional changes with the development of the pathological processes. Both after the fourth and eighth weeks after colon cancer induction, integrated intensityand aspect ratio values have shown significant statistical differences compared with control samples. Thus, SHG microscopy has proved to be a useful quantitative tool to highlight early changes of submucosa and the progression of these through the cancer development.","palabras_clave":"Colorectal cancer|Nonlinear Microscopy|Mouse"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40088,"idioma_id":4,"titulo":"Differential effect of heterocyclic D-ribofuranoside derivatives on  human prostate cancer cell viability and cell cycle progression","resumen":"New D-ribofuranoside derivatives containing two five membered heterocycles, isoxazole and triazole or two triazole rings, were synthesized. The final products as well as the synthetic precursors were physically and spectroscopically characterized. These new diheterocyclic derivatives together with other D-riboside compounds were assessed for their impact on PC3 cell line viability. We found that exposure of prostate cancer cells to some of these compounds caused a significant inhibition of cell growth and a G0\/G1 cell cycle arrest, which was concomitant with alterations in the expression of proteins involved in cell cycle progression. Furthermore, the inhibitory activity was improved in di-heterocycles when the carbohydrate moiety was protected with a cyclopentylidene group compared to the isopropylidene analogues.","palabras_clave":"TRIAZOLE|ISOXAZOLE|D-RIBOSE|PROSTATE CANCER|PC3 CELL LINE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40089,"idioma_id":4,"titulo":"Lumbering the gauntlet: Cape Gannet fledglings killed by African Penguins","resumen":"This account presents the first known observations of Cape Gannet Morus capensis fledgling mortalities as a result of&nbsp; aggressive&nbsp; nest&nbsp; defence&nbsp; behaviour&nbsp; by&nbsp; African&nbsp; Penguins&nbsp; Spheniscus&nbsp; demersus.&nbsp; Observations&nbsp; were&nbsp; conducted in&nbsp; 2013&nbsp; on&nbsp; Bird&nbsp; Island,&nbsp; Algoa&nbsp; Bay,&nbsp; South&nbsp; Africa&nbsp; ?&nbsp; the&nbsp; world?s&nbsp; largest&nbsp; breeding&nbsp; colony&nbsp; of&nbsp; Cape&nbsp; Gannets.&nbsp; Twentyeight attacks were witnessed between 21 March and 18 May 2013 of which 16 resulted in mortality. The absence of previous observations of this phenomenon may be due to an unusually high proportion of African Penguin chicks being present relatively early on in the breeding season, associated with a potential for increased nest defence at this stage, and a larger number of gannet fledglings that year compared to previous years over the same period.","palabras_clave":"INTERSPECIFIC AGGRESSION|NEST DEFENSE BEHAVIOUR|SEABIRDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40090,"idioma_id":4,"titulo":"Multidrug resistance protein 4\/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia","resumen":"Less than a third of adults patients with acute myeloid leukemia (AML) are cured by current treatments, emphasizing the need for new approaches to therapy. We previously demonstrated that besides playing a role in drug-resistant leukemia cell lines, multidrug resistance protein 4 (MRP4\/ABCC4) regulates leukemia cell proliferation and differentiation through the endogenous MRP4\/ABCC4 substrate, cAMP. Here, we studied the role of MRP4\/ABCC4 in tumor progression in a mouse xenograft model and in leukemic stem cells (LSCs) differentiation. We found a decrease in the mitotic index and an increase in the apoptotic index associated with the inhibition of tumor growth when mice were treated with rolipram (PDE4 inhibitor) and\/or probenecid (MRPs inhibitor). Genetic silencing and pharmacologic inhibition of MRP4 reduced tumor growth. Furthermore, MRP4 knockdown induced cell cycle arrest and apoptosis in vivo. Interestingly, when LSC population was isolated, we observed that increased cAMP levels and MRP4\/ABCC4 blockade resulted in LSCs differentiation. Taken together, our findings show that MRP4\/ABCC4 has a relevant role in tumor growth and apoptosis and in the eradication of LSCs, providing the basis for a novel promising target in AML therapy.","palabras_clave":"LEUKEMIA STEM CELL|MULTIDROG RESISTENCE PROTEIN|STEM CELL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40091,"idioma_id":4,"titulo":"Differential Beta2-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines","resumen":"Breast cancer is the most frequent malignancy in women. Several reports demonstrated that adrenergic receptors (ARs) are involved in breast cancer. Here we observed that epinephrine (Epi), an endogenous AR agonist, caused opposite effects in non-tumorigenic (MCF-10A and HBL-100) and tumor cells (MCF-7 and MDA-MB-231). Thus, Epi, in non-tumor breast cells, as well as isoproterenol (Beta-agonist), in all cell lines, maintained a benign phenotype, decreasing cell proliferation and migration, and stimulating cell adhesion. Beta-AR expression and cAMP levels were higher in MCF-10A than in MCF-7 cells. Beta2-AR knock-down caused a significant increase of cell proliferation and migration, and a decrease of cell adhesion both in basal and in Iso-stimulated conditions. Coincidently, Beta2-AR over-expression induced a significant decrease of cell proliferation and migration, and an increase of cell adhesion. Therefore, Beta2-AR is implied in cell phenotype and its agonists or antagonists could eventually complement cancer therapy.","palabras_clave":"HUMAN BREAST CANCER CELLS|NON-TUMORIGENIC BREAST CELLS|EPINEPHRINE|ADRENERGIC RECEPTORS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40092,"idioma_id":4,"titulo":"Generalized multi-terminal decoherent transport: recursive algorithms and applications to SASER and giant magnetoresistance","resumen":"Decoherent transport in mesoscopic and nanoscopic systems can be formulated  in terms of the D´Amato-Pastawski (DP) model. This generalizes the  Landauer-B'{u}ttiker picture by considering a distribution of local decoherent  processes. However, its generalization for multi-terminal setups is lacking. We  first review the original two-terminal DP model for decoherent transport. Then,  we extend it to a matrix formulation capable of dealing with multi-terminal  problems. We also introduce recursive algorithms to evaluate the Green´s  functions for general banded Hamiltonians as well as local density of states,  effective conductances and voltage profiles. We finally illustrate the method  by analyzing two problems of current relevance. 1) Assessing the role of  decoherence in a model for phonon lasers (SASER). 2) Obtaining the classical  limit of Giant Magnetoresistance from a spin-dependent Hamiltonian. The  presented methods should pave the way for computationally demanding  calculations of transport through nanodevices, bridging the gap between fully  coherent quantum schemes and semiclassical ones.","palabras_clave":"Quantum transport|Decoherence|Conductance|GMT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40093,"idioma_id":5,"titulo":"Análisis de la Oferta Educativa Superior en el NOA","resumen":"La educación superior ha experimentado un importante crecimiento en los últimos años. La oferta educativa ha aumentado considerablemente, tanto desde el punto de vista de instituciones como así también de carreras impartidas. Este hecho va de la mano con un aumento importante de la demanda de educación superior.  En este contexto, el presente trabajo analiza la oferta educativa superior en el caso del NOA desde el punto de vista de las Universidades participantes como así también de las disciplinas impartidas. Se logra establecer un ordenamiento en cuanto a la oferta educativa de las distintas disciplinas.  Adicionalmente se expande el análisis a nivel nacional para analizar los mercados laborales en los cuales se desempeñan los distintos tipos de profesionales. Aspectos de demanda laboral relativa son analizados a nivel de carreras.  Por último se pretende tener indicadores de la rentabilidad de las distintas profesiones. Para ello se utiliza el herramental econométrico de ecuaciones de Mincer y se estiman tasas de retorno para las distintas profesiones.","palabras_clave":"tasas de retorno|oferta educativa|mercado laboral"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40095,"idioma_id":4,"titulo":"A Gigantic, Exceptionally Complete Titanosaurian Sauropod Dinosaur from Southern Patagonia, Argentina","resumen":"Titanosaurian sauropod dinosaurs were the most diverse and abundant large-bodied herbivores in thesouthern continents during the final 30 million years of the Mesozoic Era. Several titanosaur species areregarded as the most massive land-living animals yet discovered; nevertheless, nearly all of these gianttitanosaurs are known only from very incomplete fossils, hindering a detailed understanding of theiranatomy. Here we describe a new and gigantic titanosaur, Dreadnoughtus schrani, from UpperCretaceous sediments in southern Patagonia, Argentina. Represented by approximately 70% of thepostcranial skeleton, plus craniodental remains, Dreadnoughtus is the most complete giant titanosauryet discovered, and provides new insight into the morphology and evolutionary history of these colossalanimals. Furthermore, despite its estimated mass of about 59.3 metric tons, the bone histology of theDreadnoughtus type specimen reveals that this individual was still growing at the time ofdeath.","palabras_clave":"Titanosaurian|Gigantic|Exceptionally Complete|Southern Patagonia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40096,"idioma_id":4,"titulo":"Novel high-performance purification protocol of recombinant CNBP suitable for biochemical and biophysical characterization","resumen":"Cellular nucleic acid binding protein (CNBP) is a highly conserved multi-zinc knuckle protein that enhances c-MYC expression, is related to certain human muscular diseases and is required for proper rostral head development. CNBP binds to single-stranded DNA (ssDNA) and RNA and acts as nucleic acid chaperone. Despite the advances made concerning CNBP biological roles, a full knowledge about the structure?function relationship has not yet been achieved, likely due to difficulty in obtaining pure and tag-free CNBP. Here, we report a fast, simple, reproducible, and high-performance expression and purification protocol that provides recombinant tag-free CNBP from Escherichiacoli cultures. We determined that tag-free CNBP binds its molecular targets with higher affinity than tagged-CNBP. Furthermore, fluorescence spectroscopy revealed the presence of a unique and conserved tryptophan, which is exposed to the solvent and involved, directly or indirectly, in nucleic acid binding. Size-exclusion HPLC revealed that CNBP forms homodimers independently of nucleic acid binding and coexist with monomers as non-interconvertible forms or in slow equilibrium. Circular dichroism spectroscopy showed that CNBP has a secondary structure dominated by random-coil and &#946;-sheet coincident with the sequence-predicted repetitive zinc knuckles motifs, which folding is required for CNBP structural stability and biochemical activity. CNBP structural stability increased in the presence of single-stranded nucleic acid targets similar to other unstructured nucleic acid chaperones. Altogether, data suggest that CNBP is a flexible protein with interspersed structured zinc knuckles, and acquires a more rigid structure upon nucleic acid binding.","palabras_clave":"CELLULAR NUCLEIC ACID BINDING PROTEIN|INTRINSIC FLUORESCENCE QUENCHING|INTRINSICALLY UNSTRUCTURED PROTEIN|NUCLEIC ACID BINDING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40097,"idioma_id":4,"titulo":"Fermented whey as poultry feed additive to prevent fungal contamination","resumen":"SUMMARY  The aim of the present study was to analyze the effectiveness of whey fermented with kefir grains as additive to prevent fungal contamination of poultry feed. The viability of kefir microorganisms in poultry feed was also evaluated. Cheese whey fermented 24 h at 20 °C with kefir grains (10 % w\/v) displayed a high capacity to inhibit conidial germination of Aspergillus flavus, Aspergillus parasiticus, Aspergillus terreus, Aspergillus fumigatus, Penicillium crustosum, Trichoderma longibrachiatum, and Rhizopus sp. The antifungal effect was associated with its content of undissociated lactic and acetic acid. Poultry feed was added (1 ml\/g) with: fermented whey (pH 3.6), whey containing the same pH and concentration of lactic and acetic acid than fermented whey, whey acidified with HCl to pH 3.6 or water (control). The 4 different poultry feed were artificially contaminated separately with conidia of the 7 fungi species before mentioned and the time at which moulds became visible was determined. Feed added with fermented whey was more resistant to fungal contamination than others, being the time without fungal growth extended with respect to the control 2 to 4 times depending on the fungal specie. Additionally, it contained kefir microorganisms in concentration 1 x 108 colony forming unit (CFU)\/kg of lactic acid bacteria and 6 x 107 CFU\/kg of yeasts even after 30 days of storage. Therefore the addition of fermented whey to poultry feed acts as biopreservative improving its resistance to fungi contamination and constituted a source of microorganisms potentially beneficial to chicken health.      Keywords: whey, poultry feed, fungi, kefir, biopreservation","palabras_clave":"Whey|Biopreservation|fungi|Poultry"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40098,"idioma_id":4,"titulo":"The PI3K\/AKT\/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance.","resumen":"Virchows Arch. 2014 Jul;465(1):25-33. doi: 10.1007\/s00428-014-1588-4. Epub 2014 May 21.The PI3K\/AKT\/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance.Tapia O1, Riquelme I, Leal P, Sandoval A, Aedo S, Weber H, Letelier P, Bellolio E, Villaseca M, Garcia P, Roa JC.Author informationAbstractSignaling pathway alterations are important in the development of gastric cancer (GC). Deregulation of the PI3K\/AKT\/mTOR pathway plays a crucial role in the regulation of multiple cellular functions including cell growth, proliferation, metabolism, and angiogenesis. Our goal was to assess expression of proteins involved in the PI3K\/AKT\/mTOR pathway by immunohistochemistry (IHC) in tumor and nontumor gastric mucosa from patients with advanced GC. We evaluated 71 tumor and 71 nontumor gastric mucosa samples from advanced GC patients, selected from Hernán Henríquez Aravena Hospital (Temuco, Chile). The targets studied were PI3K, AKT, p-AKT, PTEN, mTOR, p-mTOR, P70S6K1, p-P70S6K1, 4E-BP1, p-4E-BP1, eIF4E, and p-eIF4E. Expression data were correlated with clinicomorphological data. Descriptive and analytical statistics were used (95 % confidence interval, p < 0.05). For survival analyses, the Kaplan-Meier method and the log-rank test were used. PI3K, AKT, p-AKT, p-mTOR, p-4E-BP1, P70S6K1, p-P70S6K1, eIF-4E, and p-eIF-4E proteins were significantly overexpressed in tumor tissue. Conversely, PTEN was underexpressed in tumor tissue, notably in pT3-pT4 tumors (p = 0.02) and tumors with lymph node metastases (p < 0.001). P70S6K1 expression was associated with pT3-pT4 tumors (p = 0.03). Moreover, PI3K (p = 0.004), AKT (p = 0.01), p-AKT (p = 0.01), P70S6K1 (p = 0.04), p-P70S6K1 (p = 0.001), and eIF-4E (p = 0.004) were overexpressed in tumors with lymph node metastases. Low expression of 4E-BP1 was associated with poor overall survival (p = 0.03). Our results suggest that the PI3K\/AKT\/mTOR pathway is activated in GC, with overexpression in tumor tissue of most of the studied proteins (total and phosphorylated). These might be considered as target for specific targeted therapy in GC.","palabras_clave":"PI3K\/AKT\/mTOR |GASTRIC CANCER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40099,"idioma_id":4,"titulo":"Complete pathological response to Imatinib mesylate in an extraintestinal gastrointestinal stromal tumor","resumen":"Int J Surg Case Rep. 2014 Aug 15;5(10):681-685. doi: 10.1016\/j.ijscr.2014.05.009. [Epub ahead of print]Complete pathological response to Imatinib mesylate in an extraintestinal gastrointestinal stromal tumor.Quezada N1, Acevedo F2, Marambio A1, León F1, Galindo H2, Roa JC3, Jarufe N4.Author informationAbstractINTRODUCTION:Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors of the digestive tract. Extraintestinal locations (EGIST) have been described showing similar pattern of immunohistochemical markers than GIST. Inhibitors of tyrosine kinases such as Imatinib or Sunitinib are the mainstay treatment in the management of advanced or metastatic GIST. Complete pathological response to these agents is an extremely rare event, especially in the case of EGIST due to its more aggressive behavior reported.PRESENTATION OF CASE:Here we describe the case of a 61 years old woman, with an advanced GIST, who was operated after 10 months of Imatinib mesylate. The biopsy demonstrated the extra intestinal location of the tumor and a complete pathological response was confirmed.DISCUSSION:Complete pathological response to Imatinib is a rare event. To our knowledge, this is the first report of complete response in an EGIST. New clinical, radiological and metabolic criteria of tumoral response to neoadjuvant treatment are revised.CONCLUSION:EGIST complete pathological response to Imatinib can be achieved. However, recommendation of systematic neoadjuvant therapy with Imatinib remains investigational and more studies are warranted in the future.Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.KEYWORDS:Complete pathological response; EGIST; GIST; ImatinibPMID: 25194604 [PubMed - as supplied by publisher] Free full text","palabras_clave":"Imatinib|Tumor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40100,"idioma_id":4,"titulo":"Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population","resumen":"Epigenetics. 2014 Feb 1;9(2):308-17. doi: 10.4161\/epi.27120. Epub 2013 Nov 15.Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population.Brebi P1, Maldonado L2, Noordhuis MG3, Ili C1, Leal P1, Garcia P4, Brait M5, Ribas J6, Michailidi C2, Perez J2, Soudry E2, Tapia O4, Guzman P4, Muñoz S7, Van Neste L8, Van Criekinge W9, Irizarry R10, Sidransky D2, Roa JC11, Guerrero-Preston R2.Author informationAbstractCervical cancer is a major health concern among women in Latin America due to its high incidence and mortality. Therefore, the discovery of molecular markers for cervical cancer screening and triage is imperative. The aim of this study was to use a genome wide DNA methylation approach to identify novel methylation biomarkers in cervical cancer. DNA from normal cervical mucosa and cervical cancer tissue samples from Chile was enriched with Methylated DNA Immunoprecipitation (MeDIP), hybridized to oligonucleotide methylation microarrays and analyzed with a stringent bioinformatics pipeline to identify differentially methylated regions (DMRs) as candidate biomarkers. Quantitative Methylation Specific PCR (qMSP) was used to study promoter methylation of candidate DMRs in clinical samples from two independent cohorts. HPV detection and genotyping were performed by Reverse Line Blot analysis. Bioinformatics analysis revealed GGTLA4, FKBP6, ZNF516, SAP130, and INTS1 to be differentially methylated in cancer and normal tissues in the Discovery cohort. In the Validation cohort FKBP6 promoter methylation had 73% sensitivity and 80% specificity (AUC = 0.80). ZNF516 promoter methylation was the best biomarker, with both sensitivity and specificity of 90% (AUC = 0.92), results subsequently corroborated in a Prevalence cohort. Together, ZNF516 and FKBP6 exhibited a sensitivity of 84% and specificity of 81%, when considering both cohorts. Our genome wide DNA methylation assessment approach (MeDIP-chip) successfully identified novel biomarkers that differentiate between cervical cancer and normal samples, after adjusting for age and HPV status. These biomarkers need to be further explored in case-control and prospective cohorts to validate them as cervical cancer biomarkers.KEYWORDS:MeDIP; biomarkers; cervical cancer; companion diagnostics; promoter methylationPMID: 24241165 [PubMed - in process] PMCID: PMC3962541 [Available on 2015\/2\/1]","palabras_clave":"ZNF516|FKBP6| HPV"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40101,"idioma_id":4,"titulo":"Human pleural B cells regulate IFN-&#947; production by local T and NK cells in Mycobacterium tuberculosis-induced delayed hypersensitivity reaction.","resumen":"Delayed type hypersensitivity (DTH) reactions are secondary cellular immune responses,which appear 24-72 hours after antigen exposure. Tuberculous pleurisy is a common manifestation of extrapulmonary tuberculosis (TB) and considered a human model of TH1-mediated DTH. In order to identify functional cross-talk among cellular populations sited at this inflammatory microenvironment, we analyzed phenotypic and functional features of human B cells isolated from pleural fluid (PF) of TB patients. Freshly isolated PF-B cells displayed a lower expression of CD20, CD1d and HLA-DR, and a higher expression of CD95,CD38, CD25, CXCR3 and CXCR4 than their peripheral blood counterpart, suggesting a nonclassical in situ activation. Despite memory PF-T cells frequencies were increased, frequencies of memory PF-B cells were not. We demonstrated that upon stimulation with &#947;-irradiated M. tuberculosis (Mtb), mycobacterial secreted proteins or a lectin mitogen, PF-B cells showed a strong activation and produced IL-10 by a mechanism that was dependent on bystander activation of CD19neg-PF cells. Besides, within PF cells, B cells diminished in vitro Mtb-induced IFN-&#947; production by T and NK cells in an IL-10-dependent manner. Finally, we found that the lower the frequency of B cells, the higher the ratio of IFN-&#947;\/IL-10 within PF.Thus, our results suggest that B cells can regulate a human DTH reaction induced by Mtb.","palabras_clave":"B cell|delayed hipersensitivity reaction|IL-10|Th1 profile|tuberculous pleurisy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40102,"idioma_id":4,"titulo":"Ontogenetic variation in the stratum granulosum of the epidermis of Chaetophractus vellerosus (Xenarthra, Dasypodidae) in relation to the development of cornified scales","resumen":"tThe epidermis of mammals is characterized by having a stratum granulosum that produces an orthok-eratotic stratum corneum, different from the typical reptilian parakeratotic stratum. Nonetheless, somemammals show distinct degrees of parakeratosis in epidermal regions with few or no pilose follicles (e.g.,areas subjacent to cornified scales). With respect to the epidermis and the development of cornified scalesin the Dasypodidae, previous studies have supported the presence of a continuous stratum granulosumwithout any variations during ontogeny. This condition, in which the cornified scales develop withouta loss of the stratum granulosum, was interpreted as primitive for eutherians. The present contributionexpands the knowledge on the epidermis of Chaetophractus vellerosus in distinct ontogenetic stages inorder to determine whether the cornified scales show the same developmental pattern as in other euthe-rians. The presence of a stratum granulosum in C. vellerosus neonates and its reduction in more advancedontogenetic stages, in direct relationship with cornified scale development, supports the hypothesis thatthe partial parakeratosis in the xenarthran integument is secondary, as in other eutherians, and can beinterpreted as a derived character state.","palabras_clave":"Dasypodidae|Cornified scales|Parakeratosis|Chaetophractus vellerosus"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40103,"idioma_id":5,"titulo":"Pasado, presente y futuro del búfalo en Argentina","resumen":"El búfalo comenzó a ser introducido al país a comienzo el siglo XX, mediante la importación razas Mediterránea, Murrah y Jafarabadi. En la actualidad la población bubalina alcanzó las de 87.711 cabezas y se encuentran distribuidas en 20 de las 23 provincias que componen el territorio nacional. El 80 % de la población de búfalos se encuentran en el nordeste argentino. Siendo las provincias de Formosa y Corrientes las que cuentan  con la mayores poblaciones bubalinas. Existen en el país 8 millones de hectáreas aptas para soportar una carga de 4 millones de búfalos.","palabras_clave":"Búfalos|Población |Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40104,"idioma_id":4,"titulo":"Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections","resumen":"The advent of high-throughput sequencing techniques has made it possible to follow the genomic evolution of pathogenic bacteria by comparing longitudinally collected bacteria sampled from human hosts. Such studies in the context of chronic airway infections by Pseudomonas aeruginosa in cystic fibrosis (CF) patients have indicated high bacterial population diversity. Such diversity may be driven by hypermutability resulting from DNA mismatch repair system (MRS) deficiency a common trait evolved by P. aeruginosa strains in CF infections. No studies to date have utilized wholegenome sequencing to investigate within-host population diversity or long-term evolution of mutators in CF airways.  We sequenced the genomes of 13 and 14 isolates of P. aeruginosa mutator  populations from an Argentinian and a Danish CF patient, respectively. Our collection of isolates spanned 6 and 20 years of patient infection history, respectively. We sequenced 11 isolates from a single sample from each patient to allow in-depth analysis of population diversity. Each patient was infected by clonal populations of bacteria that were dominated by mutators. The in vivo mutation rate of the populations was ~100 SNPs\/year -- ~40-fold higher than rates in normo-mutable populations. Comparison of the genomes of 11 isolates from the same sample showed extensive within-patient genomic diversification; the populations were composed of different sublineages that had coexisted for many years since the initial colonization of the patient. Analysis of the mutations identified genes that underwent convergent evolution across  lineages and sub-lineages, suggesting that the genes were targeted by mutation to optimize pathogenic fitness. Parallel evolution was observed in reduction of overall catabolic capacity of the populations.  These findings are useful for understanding the evolution of pathogen populations and identifying new targets for control of chronic infections.","palabras_clave":"PSEUDOMONAS AERUGINOSA|MUTATORS|MISMATCH REPAIR SYSTEM|CYSTIC FIBROSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40105,"idioma_id":4,"titulo":"Hypermutation in Burkholderia cepacia complex is  mediated by DNA mismatch repair inactivation and is highly prevalent in cystic fibrosis chronic respiratory infection","resumen":"The Burkholderia cepacia complex (Bcc) represents an important group of pathogens involved in long-termlung infection in cystic fibrosis (CF) patients. A positive selection of hypermutators, linked to antimicro-bial resistance development, has been previously reported for Pseudomonas aeruginosa in this chronicinfection setting. Hypermutability, however, has not yet been systematically evaluated in Bcc species.A total of 125 well characterized Bcc isolates recovered from 48 CF patients, 10 non-CF patients and 15environmental samples were analyzed. In order to determine the prevalence of mutators their spon-taneous mutation rates to rifampicin resistance were determined. In addition, the genetic basis of themutator phenotypes was investigated by sequencing the mutS and mutL genes, the main components ofthe mismatch repair system (MRS). The overall prevalence of hypermutators in the collection analyzedwas 13.6%, with highest occurrence (40.7%) among the chronically infected CF patients, belonging mainlyto B. cenocepacia, B. multivorans, B. cepacia, and B. contaminans ? the most frequently recovered Bcc speciesfrom CF patients worldwide. Thirteen (76.5%) of the hypermutators were defective in mutS and\/or mutL.Finally, searching for a possible association between antimicrobial resistance and hypermutability, theresistance-profiles to 17 antimicrobial agents was evaluated. High antimicrobial resistance rates weredocumented for all the Bcc species recovered from CF patients, but, except for ciprofloxacin, a significantassociation with hypermutation was not detected. In conclusion, in the present study we demonstratefor the first time that, MRS-deficient Bcc species mutators are highly prevalent and positively selected inCF chronic lung infections. Hypermutation therefore, might be playing a key role in increasing bacterialadaptability to the CF-airway environment, facilitating the persistence of chronic lung infections","palabras_clave":"Burkholderia cepacia complex|Hypermutation|Cystic fibrosis|Chronic infections"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40106,"idioma_id":4,"titulo":"Otolith Eco-Morphological Patterns Of Benthic Fishes From The Coast of Valencia (Spain).","resumen":"Benthic fishes exhibit different adaptive strategies and different degrees of association with the substrate. The aim of this study is to  describe the morphologic and morphometric characteristic of otolith of four species of benthonic fish off the coast of Valencia and study  the relationship between these otolith´s characteristics witch the substrate. The sagittae analysed belonged to the following species:  Scorpaena scrofa Linnaeus, 1758 (N=40), Mullus surmuletus Linnaeus, 1758 (N=29), Uranoscopus scaber Linnaeus, 1758 (N=24) and  Synaptura lusitanica Capello, 1868 (N=121). The fishes were sexed, the total length (TL) was measured in mm, and the sagittae were  removed to examine their morphology and morphometry. The E (=maximum width of the otolith (OW)\/ maximum length of the otolith  (OL)%) and S (sulcus area (SS)\/otolith area (OS) %) index were calculated. The E morphometric index showed a tendency towards an  elongated or circular shape and the S index showed a tendency of macula nervous to have a greater surface area of information uptake  to transmit to the fish brain. The analysis of otolith morphology and morphometry revealed the existence of different eco-morphological  patterns associated with habitat use and the type of substrate where the fish is most frequently found. The E and S index have proven to  be useful for discriminating between the sagittae of fishes from different water column uses and are associated a different substrates type.","palabras_clave":"otolito|peces comerciales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40107,"idioma_id":4,"titulo":"Asymmetric construction of substituted pyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides and chiral acrylates derived from biomass","resumen":"The first application of chiral auxiliaries synthesized from levoglucosenone (a biomass-derived anhydrosugar) in asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides is herein reported. The corresponding pyrrolidinic cores were obtained in excellent levels of regio and stereocontrol, good to excellent &#960;-facial selectivities, and could be isolated enantiomerically pure by column chromatography. Unexpected NMR observations coupled with DFT calculations allowed the stereochemical assignment of the synthesized adducts. The stereochemical assignment performed in silico was further unambiguously validated by structural X-ray diffraction analysis.","palabras_clave":"ASYMMETRIC SYNTHESIS|PYRROLIDINES|1,3-DIPOLAR CYCLOADDITION|BIOMASS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40108,"idioma_id":5,"titulo":"Edema pulmonar agudo","resumen":"El edema pulmonar se puede definir como un incremento normal en el volumen de líquido extravascular presente en el parénquima pulmonar. En animales de compañía se distinguen&nbsp;2 grandes formas fisiopatológicas capaces de generarlo: 1) Edema por incremento de presión hidrostática y 2) Edema por aumento de la permeabilidad vascular. La mayoría de los pacientes caninos y felinos con edema pulmonar, independientemente de la fisiopatología que le ha dado origen, tienen taquipnea y disnea de moderada a grave. El manejo clínico inicial debe orientarse a estabilizar el paciente y a determinar la gravedad del cuadro respiratorio, antes de determinar la causa del mismo. La administración de oxígeno ad-libitum al 100% es en todos los casos beneficiosa. La radiología de tórax es el método diagnóstico por elección ya que permite evaluar toda la caja toráxica, sin embargo su técnica de realización requiere un paciente estabilizado de manera de que pueda soportar el estrés del procedimiento. La disminución de la presión hidrostática pulmonar a partir de la restricción de fluidos, diuréticos y vasodilatadores se considera la terapia más racional para tratar el edema pulmonar agudo independientemente de cual sea la causa del mismo.&nbsp;","palabras_clave":"EDEMA|PULMÓN|TRATAMIENTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40109,"idioma_id":4,"titulo":"Immune response of heifers against a Staphylococcus aureus CP5 whole cell and lysate vaccine formulated with ISCOM Matrix adjuvant","resumen":"Staphylococcus aureus is the most frequently isolated pathogen from bovine intramammary22 infections worldwide. Commercially available vaccines for mastitis control are composed either23 of S. aureus lysates or whole-cells formulated with traditional adjuvants. We recently showed24 the ability of a S. aureus CP5 whole-cell vaccine adjuvanted with ISCOM Matrix to increase25 specific antibodies production in blood and milk, improving opsonic capacity, compared with26 the same vaccine formulated with Al(OH)3. However, there is no information about the use of27 ISCOM Matrix for the formulation of bacterial lysates. The aim of this study was to28 characterize the innate and humoral immune responses induced by a S. aureus CP5 whole-cell29 or lysate vaccine, formulated with ISCOM Matrix after immunization of pregnant heifers. Both30 immunogens stimulated strong humoral immune responses in blood and milk, raising antibodies31 that increased opsonic capacity. Lysate formulation generated a higher and longer lasting32 antibody titer and stimulated a higher expression of regulatory and pro-inflammatory cytokines33 compared with the whole-cell vaccine.","palabras_clave":"MASTITIS|STAPHYLOCOCCUS AUREUS|IMMUNIZATION|WHOLE CELL|LYSATE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40110,"idioma_id":4,"titulo":"Citrobacter freundii infection in two captive Australian king parrots (Alisterus scapularis)","resumen":"An adult and a juvenile male Australian king parrot (Alisterus scapularis) were found dead in their facilities in a private aviary in June 2010 without premonitory clinical signs before death. Gross examinations showed enlarged livers, enlarged spleens with petechiae, distended proventriculi, and distended and haemorrhagic intestinal tracts. Unilateral pneumonia and enlarged kidneys were also observed in the adult parrot. Tissue samples from the heart, lungs, liver, spleen, kidneys, proventriculus and intestine were analysed using real-time polymerase chain reaction, histopathological, and bacteriological studies. Citrobacter freundii was isolated from several organs in the two parrots. To the authors? knowledge, this is the first report of a C. freundii infection causing lesions and sudden death in Psittaciformes.","palabras_clave":"Bacteraemia|Enterobacteriaceae|Psittaciformes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40111,"idioma_id":4,"titulo":"Diagnosis of an outbreak of Salmonella Typhimurium in chinchillas (Chinchilla lanigera) by pulsed-field gel electrophoresis","resumen":"Adult chinchillas (Chinchilla lanigera) that had suddenly died in a commercial farm located in La Plata City, Buenos Aires Province, Argentina, in July 2012 were macroscopically, histopathologically, and microbiologically examined. Salmonella enterica serovar Typhimurium (S. Typhimurium) was isolated from the liver, spleen, heart, lungs, kidneys and intestines from each of the five animals evaluated. The five strains were susceptible to ampicillin, cephalotin, cefotaxime, nalidixic acid, gentamicin, streptomycin, chloramphenicol, fosfomycin, nitrofurantoin and trimethoprimsulfamethoxazole,and resistant to tetracycline. Each of the five S. Typhimurium isolates was analyzed by XbaI- pulsed-fi eld gel electrophoresis (PFGE), showing an identical electrophoretic profile with 15 defined bands, which was found to be identical to pattern  ARJPXX01.0220 of the PulseNet Argentine National database of Salmonella PFGE patterns. This is the first work describing the postmortem diagnosis of an outbreak of salmonellosis in chinchillas by using molecular methods such as PFGE.","palabras_clave":"Chinchilla lanigera|Farmed chinchillas|PFGE|Salmonella Typhimurium|Zoonosis"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40112,"idioma_id":4,"titulo":"Evidence of association of a BTA20 region peaked in ISL1 with puberty in Angus bulls","resumen":"In bovine, there are significant differences among and within breeds in   the time when bulls reach puberty. Reported data indicate that age at   puberty has a strong genetic component and is a multigenic trait.   However, despite significant advancements in the field, the gene network   controlling puberty is very complex, containing a host of genes that   exert their effect on the hypothalamic?pituitary?gonadal (HPG) axis, and   several aspects of regulation of the HPG axis are yet to be fully   elucidated. The objective of this work was to identify new genes   associated with age at puberty. Angus males (N=276) were   weighted and scrotal circumference measured every month. When first bull   calves reached 26&nbsp;cm of scrotal circumference, sperm quality was added   to the monthly measurements for the next three months. Based on sperm   quality, two groups corresponding to the top and bottom 6.5% of the   phenotypic distribution curve were selected to perform a genome-wide   association study using a selective DNA approach, to be used as an exploratory analysis. Based on the results of this preliminary study,   five SNPs located within BTA3, 20 and 24 associated regions were   genotyped in the 276 bulls using pyrosequencing methods. This analysis   allowed us to confirm the association of a BTA20 region with age at   puberty estimated at C 50 million. The associated SNP explained 1.69% of the genetic variance of age at puberty at C 50 million. The associated region contained within and nearby positional candidate genes (ISL1, PELO, FST, SPZ1)   that may be involved in spermatogenesis. Our results should encourage   further investigation to confirm the role of these genes in order to   increase our knowledge on genetic control of bovine puberty.","palabras_clave":"PUBERTY|BULLS|GWAS|SNP"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40113,"idioma_id":4,"titulo":"FOREIGN MEAT IDENTIFICATION BY DNA BREED ASSIGNMENT IN CHINESE MARKET","resumen":"Abstract: Individual identification is mainly used for food safety, while breed determination is useful in commercial frauds. In the context of Chinese imports there is a need to trace meat origin. Chinese Yellow cattle (CYC) samples, representing North and Central Agricultural regions, six Bos taurus, two Bos indicus and one composite breeds were used. 22 microsatellites were selected to evaluate if samples from those breeds could be recognized from CYC. Breed assignment reveals that all foreign breeds could be discriminated from CYC but some CYC were wrongly allocated as Limousin or Holstein, probably due to recent introduction to China. CYC samples evidence two genetic structures: a Bos indicus cline (south-north) and two different Bos taurus components (east-west). An allocation test  performed with unknown breed Argentinean samples, result in a 92%  belonging to Angus, Hereford or its crossbreeds, and none was CYC. This method is satisfactory to certify foreign breed meat and detect  adulterations of CYC beef labeled as imported meat.","palabras_clave":"traceability|breed|DNA|China|meat|microsatellites"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40114,"idioma_id":4,"titulo":"New patterns of methicillin-resistant Staphylococcus aureus (MRSA) clones, community-associated MRSA genotypes behave like healthcare-associated MRSA genotypes within hospitals, Argentina","resumen":"Methicillin-resistant Staphylococcus aureus (MRSA) burden is increasing worldwide in hospitals [healthcare-associated (HA)-MRSA] and in communities [community-associated (CA)-MRSA]. However, the impact of CA-MRSA within hospitals remains limited, particularly in Latin America. A countrywide representative survey of S. aureus infections was performed in Argentina by analyzing 591 clinical isolates from 66 hospitals in a prospective cross-sectional, multicenter study (Nov-2009). This work involved healthcare-onset infections-(HAHO, &gt;48 hospitalization hours) and community-onset (CO) infections [including both, infections (HACO) in patients with healthcare-associated risk-factors (HRFs) and infections (CACO) in those without HRFs]. MRSA strains were genetically typed as CA-MRSA and HA-MRSA genotypes (CA-MRSAG and HA-MRSAG) by SCCmec- and spa-typing, PFGE, MLST and virulence genes profile by PCR. Considering all isolates, 63% were from CO-infections and 55% were MRSA [39% CA-MRSAG and 16% HA-MRSAG]. A significantly higher MRSA proportion among CO- than HAHO-S. aureus infections was detected (58% vs 49%); mainly in children (62% vs 43%). The CA-MRSAG\/HA-MRSAG have accounted for 16%\/33% of HAHO-, 39%\/13% of HACO- and 60.5%\/0% of CACO-infections. Regarding the epidemiological associations identified in multivariate models for patients with healthcare-onset CA-MRSAG infections, CA-MRSAG behave like HA-MRSAG within hospitals but children were the highest risk group for healthcare-onset CA-MRSAG infections. Most CA-MRSAG belonged to two major clones: PFGE-type N-ST30-SCCmecIVc-t019-PVL+ and PFGE-type I-ST5-IV-SCCmecIVa-t311-PVL+ (45% each). The ST5-IV-PVL+\/ST30-IV-PVL+ clones have caused 31%\/33% of all infections, 20%\/4% of HAHO-, 43%\/23% of HACO- and 35%\/60% of CACO- infections, with significant differences by age groups (children\/adults) and geographical regions. Importantly, an isolate belonging to USA300-0114-(ST8-SCCmecIVa-spat008-PVL+-ACME+) was detected for the first time in Argentina. Most of HA-MRSAG (66%) were related to the Cordobes\/Chilean clone-(PFGE-type A-ST5-SCCmecI-t149) causing 18% of all infections (47% of HAHO- and 13% of HACO-infections).Results strongly suggest that the CA-MRSA clone ST5-IV-PVL+ has begun to spread within hospitals, replacing the traditional Cordobes\/Chilean-HA-MRSA clone ST5-I-PVL&#8722;, mainly in children. Importantly, a growing MRSA reservoir in the community was associated with spreading of two CA-MRSA clones: ST5-IV-PVL+, mainly in children with HRFs, and ST30-IV-PVL+ in adults without HRFs. This is the first nationwide study in Argentina providing information about the molecular and clinical epidemiology of CA-MRSA, particularly within hospitals, which is essential for designing effective control measures in this country and worldwide.","palabras_clave":"STAPHYLOCOCCUS|METHICILLIN|MRSA|GENOTYPES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40115,"idioma_id":5,"titulo":"Alteraciones ultramicroscópicas observadas en espermatozoides felinos (Felis Catus) congelados-descongelados","resumen":"Los procesos de criopreservación seminal producen alteraciones estructurales en la célula espermática provocando disminución de la fertilidad al descongelado. El objetivo de este trabajo fue estudiar las alteraciones ultramicroscópicas observadas en los espermatozoides felinos  congelados-descongelados. Se utilizaron 16 gatos (n=16) mestizos, de entre 24 y 36 meses de edad, sanos, con un peso entre 3 y 5 Kg, los cuales fueron sometidos a orquiectomía bilateral para la obtención de espermatozoides a partir de la cola del epidídimo con la técnica de cutting. Los espermatozoides epididimales se congelaron con dos diluyentes diferentes: un DIL Tris Base y un DIL Tris con el agregado de 0,5% de Dimetilformamida y 4,5% de glicerol. Las muestras de espermatozoides epididimales frescos y congelados-descongelados se procesaron y observaron en un microscopio electrónico de transmisión JEM 1200 EX II. Se evaluaron 100 cabezas y 100 colas por cada tratamiento. El  porcentaje de espermatozoides sin daños ultramicroscópicos fue significativamente mayor en el semen fresco que en el semen descongelado  (80,75±5,64 vs 10,25±1,24; 91,75±2,13 vs 59,27±3,92; p<0,05). Los procesos de congelación-descongelación producen alteraciones espermáticas  ultraestructurales.","palabras_clave":"ESPERMATOZOIDES|FELINO|CRIOPRESERVACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40116,"idioma_id":4,"titulo":"Effects of supplementing endophyte-infected tall fescue with sainfoin and polyethylene glycol on the physiology and ingestive behavior of sheep","resumen":"                      Tannins in sainfoin (Onobrychis viciifolia) may bind to alkaloids  in          endophyte-infected tall fescue (E+; Lolium arundinaceum [Schreb.]  Darbysh) and          attenuate toxicosis. If so, supplementing E+ with sainfoin will increase  use of E+ by          sheep, and polyethylene glycol (PEG) -a polymer that selectively binds  to tannins- will          reduce such response. To test these predictions, thirty-six 2-month-old  lambs were          randomly assigned to 3 treatments (12 lambs\/treatment). During exposure,  all lambs were          individually penned and fed E+ supplemented with: beet pulp (CTRL),  fresh-cut sainfoin          and beet pulp (SAIN), or fresh-cut sainfoin + PEG mixed in beet pulp  (SAIN+PEG).          Feed intake was measured daily. Rectal temperatures and jugular blood  samples were          taken at the beginning and end of exposure. After exposure, all lambs  were offered          choices between endophyte-free fescue (E-) and orchardgrass, and  preference for E- was          assessed. Then, all lambs were allowed to graze a choice of E+ and  sainfoin, or a          monoculture of E+. The foraging behavior of lambs was recorded. When  sainfoin was in          mid-vegetative stage, lambs in SAIN ingested more E+ than lambs in CTRL  (P = 0.05),          but no differences were detected between lambs in SAIN+PEG and CTRL (P  = 0.12).          Sainfoin supplementation improved some physiological parameters  indicative of fescue          toxicosis. Lambs in SAIN had lower rectal temperatures (P =  0.02), greater numbers of          leukocytes (P &lt; 0.001) and lymphocytes (P = 0.03), and  greater plasmatic concentrations          of globulin (P = 0.009) and prolactin (P = 0.019) than  lambs in CTRL. Some of these          differences were offset by the SAIN+PEG treatment. When lambs were  offered choices          between E- and orchardgrass, only lambs in SAIN had greater intake of E-  than lambs in          CTRL (P &lt; 0.001). When lambs were allowed to graze a choice of  E+ and sainfoin, all          treatments used E+ to the same extent (P &gt; 0.05). On the other  hand, when they grazed on a monoculture of E+, lambs in SAIN+PEG showed greater  acceptance of E+ than lambs          in SAIN or in CTRL (P &lt; 0.05). In summary, sainfoin  supplementation alleviated several          of the classic signs of fescue toxicosis and increased intake of  endophyte-infected tall          fescue. Tannins in sainfoin partially accounted for this benefit since  feeding a polymer          that selectively binds to tannins (PEG) attenuated some these responses.  However,          sainfoin supplementation during initial exposure to E+ did not lead to  an increased          preference for E+ during grazing.                    ","palabras_clave":"alkaloids|condensed tannins|fescue toxicosis|ingestive behavior"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40117,"idioma_id":4,"titulo":"Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis","resumen":"We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial. Herein, we show the modulatory action of thyroid status on the in vivo growth of T lymphoma cells. For this purpose, euthyroid, hypothyroid, and hyperthyroid mice received inoculations of EL4 cells to allow the development of solid tumors. Tumors in the hyperthyroid animals exhibited a higher growth rate, as evidenced by the early appearance of palpable solid tumors and the increased tumor volume. These results are consistent with the rate of cell division determined by staining tumor cells with carboxyfluorescein succinimidyl ester. Additionally, hyperthyroid mice exhibited reduced survival. Hypothyroid mice did not differ significantly from the euthyroid controls with respect to these parameters. Additionally, only tumors from hyperthyroid animals had increased expression levels of proliferating cell nuclear antigen and active caspase 3. Differential expression of cell cycle regulatory proteins was also observed. The levels of cyclins D1 and D3 were augmented in the tumors of the hyperthyroid animals, whereas the cell cycle inhibitors p16\/INK4A (CDKN2A) and p27\/Kip1 (CDKN1B) and the tumor suppressor p53 (TRP53) were increased in hypothyroid mice. Intratumoral and peritumoral vasculogenesis was increased only in hyperthyroid mice. Therefore, we propose that the thyroid status modulates the in vivo growth of EL4 T lymphoma through the regulation of cyclin, cyclin-dependent kinase inhibitor, and tumor suppressor gene expression, as well as the stimulation of angiogenesis.","palabras_clave":"HORMONAS TIROIDEASs|LINFOMA T|CICLINAS|ANGIOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40118,"idioma_id":4,"titulo":"First report of Rangelia vitalii infection (canine rangeliosis) in Argentina","resumen":"A 12-year old mixed breed neutered bitch from Misiones, Argentina, was presented with a history of fever and epistaxis. Blood, bone marrow, and lymph node samples were collected for hematology and cytology. Mild regenerative anemia was recorded and large, round, poorly stained piroplasms (>2.5 µm) were found within erythrocytes in blood and lymph node smears. Nested PCR-RFLP on blood and bone marrow samples was positive for piroplasm DNA. The 18S rRNA gene of piroplasms was targeted. A restriction pattern of a previously unreported piroplasm was observed. The PCR product was sequenced, and the sequence obtained had 99% identity with the Rangelia vitalii sequences from Brazil when compared by BLAST analysis. Further characterization of the detected piroplasm consisted of nearly full-length sequencing (1668 bp) of the 18S rRNA gene of this organism. Those sequences were deposited in GenBank. A phylogenetic analysis indicated that they clustered together with Rangelia vitalii from Brazil but separately from large Babesia species of dogs such as Babesia canis, and from species of Theileria of dogs as well. This is the first report of Rangelia vitalii infection in Argentina, and the first case of canine rangeliosis diagnosed outside Brazil.","palabras_clave":"CANINE|PIROPLASM|RANGELIA VITALII|RANGELIOSIS|NAMBIUVÚ|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40119,"idioma_id":4,"titulo":"Neospora caninum tachyzoites inoculated by the conjunctival route are not vertically transmitted in pregnant cattle: a descriptive study","resumen":"The aim of this study was to evaluate whether Neospora caninum tachyzoites (Nc-1) inoc-ulated by the conjunctival route in pregnant cows were able to generate infection in theirfetuses. Group 1 contained 2 naturally infected cows; group 2 contained two cows inoc-ulated intravenously with 2.5 × 108tachyzoites, group 3 contained two cows inoculatedwith 2.5 × 108tachyzoites by the conjunctival route, and group 4 contained two uninfectedcontrol cows. The four inoculated cows from groups 2 and 3 were challenged at 23 weeks ofgestation. An indirect fluorescent antibody test (IFAT), recombinant NcGRA7-based ELISA,ELISA for IgG subisotypes and Western blot analysis were assessed to characterize thehumoral immune response in dams. Sera from their fetuses were tested also using West-ern blot analysis. Routine microscopic evaluation of H&E stained fetal tissues was madeand any fetal tissues and placentas with lesions compatible with Neospora-infection wereprocessed by immunohistochemistry (IHC). DNA extraction from fresh and formalin-fixed,paraffin-embedded fetal tissues were tested by nested PCR. All dams from groups 1, 2 and 3were seropositive by IFAT, rNcGRA7-based-ELISA and Western blot. IgG1\/IgG2ratios were&#8804;1 at weeks 27 and 29 of gestation. Only fetuses from groups 1 and 2 developed N. can-inum specific antibodies by Western blot. Histopathological lesions compatible with thosecaused by N. caninum were observed in fetuses from groups 1 and 2. N. caninum cysts andtachyzoites were observed by IHC on fetal tissues from groups 1 and 2. Only fetal samplesfrom group 2 were positive by PCR. Further work is needed not only to characterize thecellular immune response but also to clarify the consequences on the dam after conjunc-tival inoculation of N. caninum tachyzoites. This study shows that N. caninum tachyzoitesinoculated by the conjunctival route were not vertically transmitted in pregnant cows.","palabras_clave":"NEOSPORA CANINUM|CONJUNCTIVA|VERTICAL|TRANSMISSION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40120,"idioma_id":4,"titulo":"Relationship between the zoo- and phytoplankton biomasses in a saline lowland river (Argentina): a short-time-scale analysis","resumen":"Short-time-scale (days) lotic investigations during low-discharge conditions are appropriate for elucidating trophic relationships within plankton. The objectives of this study were to determine the successional changes in the zooplankton biomass, the relationship of that biomass to physical parameters and palatable phytoplankton species, and to evaluate the observational time scale. Plankton samples were taken thrice weekly at two sampling stations in the Salado River lower sector (Buenos Aires province, Argentina). Since almost one-third of the country?s agricultural and cattle productions come from the Salado-River basin with their resulting impacts (nutrients, suspended material) in the basin, limnological research has been conducted there during recent decades. To estimate grazing, we employed three models and also the relationship between the zoo- and nanoplankton biomasses. The seasonal temperature and conductivity changes indicated three clearly different periods and were the main parameters driving the seasonal succession of the zooplankton. During the first period, the total zooplankton biomass was less than in the other two, with the tintinnids predominating. Later, the rotifers became prevalent with a predomination by Brachionus plicatilis and Keratella tropica. The grazing pressure of the r-strategy dominated zooplankters was highly variable. Zooplankter-species replacement by those of different grazing efficiencies promoted changes in the phytoplankton structure and nanoplankton biomass. A top-down effect on the total phytoplankton biomass by the zooplankton was not detected, though an abundance diminution for certain palatable algae was observed. The biomass of the nanoplankton species was significantly related to the total zooplankton biomass, with the highest rotifer values being associated with an exponential decrease in the nanoplankton biomass.","palabras_clave":"PLANKTON|BIOMASS|PAMPEAN LOWLAND RIVER|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40121,"idioma_id":5,"titulo":"Soberanías heridas de muerte, Estados llenos de vida","resumen":"El presente escrito se propone iluminar, desde una clave posfundacional, el concepto de soberanía en la política contemporánea. Para ello, las aproxima- ciones heterodoxas de Walter Benjamin y Jacques Derrida (ambos ?acechados? por Carl Schmitt) permiti- rán problematizar su antigua configuración, recono- ciendo el elemento contingente que la atraviesa y que funciona como fuente de su productividad. En el cruce de la melancolía benjaminiana y la incondicionalidad derridiana emerge como filigrana la clave que expone una nueva declinación de la soberanía: aquella que permite concebir un vínculo alternativo con el Estado democrático, un Estado siempre ya en deconstrucción y cuestionado en sus fundamentos.","palabras_clave":"DEMOCRACIA|SOBERANIA|MELANCOLIA|DECONSTRUCCION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40122,"idioma_id":4,"titulo":"NEUTRALISATION OF THE PHARMACOLOGICAL ACTIVITIES OF Bothrops alternatus VENOM BY ANTI-PLA2 IGGS","resumen":"Basic phospholipases A2 (PLA2) are toxic and induce a wide spectrum of pharmacological  effects, although the acidic enzyme types are not lethal or cause low lethality. Therefore, it  is challenging to elucidate the mechanism of action of acidic phospholipases. This study  used the acidic non-toxic Ba SpII RP4 PLA2 from Bothrops alternatus as an antigen to  develop anti-PLA2 IgG antibodies in rabbits and used in vivo assays to examine the changes  in crude venom when pre-incubated with these antibodies. Using Ouchterlony and  western blot analyses on B. alternatus venom, we examined the specificity and sensitivity  of phospholipase A2 recognition by the specific antibodies (anti-PLA2 IgG). Neutralisation  assays using a non-toxic PLA2 antigen revealed unexpected results. The (indirect) haemolytic  activity of whole venom was completely inhibited, and all catalytically active  phospholipases A2 were blocked. Myotoxicity and lethality were reduced when the crude  venom was pre-incubated with anti-PLA2 immunoglobulins. CK levels in the skeletal  muscle were significantly reduced at 6 h, and the muscular damage was more significant at  this time-point compared to 3 and 12 h. When four times the LD50 was used (224 mg), half  the animals treated with the venom-anti PLA2 IgG mixture survived after 48 h. All assays  performed with the specific antibodies revealed that Ba SpII RP4 PLA2 had a synergistic  effect on whole-venom toxicity. IgG antibodies against the venom of the Argentinean  species B. alternatus represent a valuable tool for elucidation of the roles of acidic PLA2 that  appear to have purely digestive roles and for further studies on immunotherapy and snake  envenoming in affected areas in Argentina and Brazil.","palabras_clave":"Envenomation|Inmunoglobulins|Bothrops alternatus|Non-myotoxic PLA2"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40123,"idioma_id":4,"titulo":"Endometrial cytology, biopsy and bacteriology for the diagnosis of subclinical endometritis in grazing dairy cows","resumen":"The objectives of this study were to assess the agreement between endometrial cytology and uterine biopsy for the diagnosis of subclinical endometritis (SEND) in grazing dairy cows, the interobserver agreement of the biopsy?s readings, and the bacterial population isolated from the uterus of cows having SEND. In experiment 1, lactating Holstein cows (n = 44) 31 to 59 d in milk (DIM) at sampling were enrolled. Clinical endometritis was diagnosed by direct evaluation of vaginal discharge and SEND by endometrial cytology evaluation. Two hundred cells per smear were counted to determine the percentage of polymorphonuclear neutrophilic leukocytes (PMNL). Cut-off values used were &#8805;8% PMNL at &#8804;33 DIM, &#8805;6% PMNL at 34 to 47 DIM, and &#8805;4% PMNL at &#8805;48 DIM. Biopsies were assessed blindly by 2 observers who categorized them into 4 groups according to their inflammatory changes: none, minimal, moderate, and severe inflammatory changes. Data were analyzed using the kappa coefficient and logistic regression. In experiment 2, lactating Holstein cows (n = 60) 21 to 62 DIM were enrolled. Clinical endometritis and SEND were diagnosed as previously described. Samples were cultured for aerobic and anaerobic bacteria by routine methods of bacteriological testing. Data were analyzed with logistic regression. In experiment 1, little agreement was observed between cytology and biopsy outputs (kappa = 0.151), and strong agreement between the 2 operators (kappa = 0.854). The likelihood of having a normal biopsy (no inflammatory change) was greater for healthy cows than for those having SEND (odds ratio = 13.145). The probability for getting normal uterine tissue decreased 2.1% for every increasing percentage point in PMNL. In experiment 2, no bacteria were isolated from cows with SEND, coagulase-negative staphylococci were commonly isolated from healthy cows, and Trueperella pyogenes was frequently isolated from cows with clinical endometritis. The likelihood of isolating T. pyogenes from uterine samples increased with the percentage of PMNL (odds ratio = 1.100). In conclusion, biopsy showed low agreement with cytology for the diagnosis of SEND. Nevertheless, fertility trials using uterine biopsies to predict pregnancy outcomes are needed to determine its diagnostic usefulness. Finally, bacteriology would not be recommended as a diagnostic tool because no bacteria were isolated from cows with SEND.","palabras_clave":"BOVINOS DE LECHE|ENDOMETRITIS SUBCLINICA|BIOPSIA UTERINA|BACTERIOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40124,"idioma_id":4,"titulo":"New immunization protocol to produce crotalic antivenom combining Crotalus durissus terrificus venom and its PLA2","resumen":"Antivenoms are usually obtained by animal immunization with successive inoculations of increasing sublethal amounts of venom, which may impair the animal health. The high lethality of venom requires prolonged immunization plans with small amounts of venom. Thus, in this paper we propose an alternative plan that includes a pre-immunization of the animal with phospholipase A2, the main component of crotoxin, which is responsible for the whole venom lethality. For comparison, three different immunizationschemeswere designed:high dose protocol (HDP; 0.5 - 27 mg of venom), low dose protocol (LDP; 0.1 - 7 mg of venom) and Mix protocol (MP;preimmunization 0.1 - 1.2 mg of crotalic PLA2, and then 4.5 - 8 mg of venom). Antibody titers were determined by ELISA, in blood plasma obtained from the marginal vein of the ear. The neutralizing ability of the different sera obtained byall protocols (HDS, LDS and MS) was tested against the most important pharmacological activities of whole venom: PLA2 activity, myotoxicity, thrombin like activity and lethality. MS showed the best neutralizing efficacy and at the same time, it was obtained by an immunization protocol that takes account of animal health care, since it requires low quantities of venoms in comparisonto traditional protocols.","palabras_clave":"Phospholipase A2|crotalic |envenomation|antivenom"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40125,"idioma_id":4,"titulo":"The early evolutionary history of neo-sex chromosomes in Neotropical grasshoppers, Boliviacris noroestensis (Orthoptera: Acrididae: Melanoplinae)","resumen":"Neo-sex chromosomes are an important component of chromosome variation in Orthoptera, particularly South American Melanoplinae species, which have proven to be outstanding experimental model system to study the mechanism of sex chromosome evolution in this group of insects. In terms of their origin, most derived sex chromosome mechanisms involve a Robertsonian fusion (i.e. translocation) between the ancestral X chromosome and an autosome. In the grasshopper, Boliviacris noroestensis Ronderos &amp; Cigliano (1990) (Orthoptera: Acrididae: Melanoplinae), our results point to a small degree of differentiation (conserved homology between the XR arm and the neo-Y) of the neo-XY chromosomes, which may be of recent evolutionary origin. However, a simple centric fusion model does not explain their origin, mainly because of the observed reduction in the fundamental number (FN) of arms. We propose two models which, we hope, clarify the genesis of B. noroestensis neo-sex chromosomes. Records of karyotype variation in related species due to multiple rearrangements support our models. We propose a possible adaptive advantage for neo-sex chromosome carriers, such changes perhaps representing the primary force that increases their frequency within natural populations compared with non-fused translocated forms, and occurring without apparent detriment to the microevolutionary forces that may also act, at least at the beginning of the evolutionary history of individuals bearing such neo-sex chromosomes.","palabras_clave":"ORTHOPTERA|ACRIDIDAE|MELANOPLINAE|CHROMOSOME REARRANGEMENT|DICHROPLINI|GENETIC DIVERGENCE|HOMOLOGY|NEO-SEX CHROMOSOMES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40126,"idioma_id":4,"titulo":"Calving assistance influence the occurrence of umbilical pathologies with surgical resolution in calves","resumen":"Ninety-two umbilical pathologies were surgically treated in Holstein, Aberdeen Angus, and Polled Hereford calves, both malesand females, whose ages ranged between 2 and 8 months. The pathology diagnosis was performed considering the main anatomicalelements involved in the umbilical cord, the inflammation progression, and the macroscopic characteristics of injuries. The umbilicalcord pathologies were related to calving characteristics. The proportion of affected umbilical cords in calves born via assisted calving(77%) was significantly higher than that observed in calves born from normal parturition. The umbilical cord pathology of highestoccurrence was omphalophlebitis (53.2%). A considerable proportion of infectious diseases of the urachus was observed (29.3%). Firstdegreeomphalophlebitis was diagnosed in a major proportion of surgical cases (30.4%) and showed significant differences in relationto the more serious pathologies of third-degree omphalophlebitis (5.4%) and third-degree omphalourachitis (5.4%). The occurrence ofumbilical cord diseases treated surgically was significantly higher in assisted calving (77%) than in eutocic birth.","palabras_clave":"Calf|omphaloarteritis|omphalophlebitis|dystocia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40127,"idioma_id":4,"titulo":"Design of an Integrated power system using a proton exchange membrane  fuel cell ?","resumen":"Integrated power systems could be a solution to provide energy to remote communities based on the use of renewable energies (such as wind or sun). This work proposed the design of one of those systems including alkaline water electrolysers, storage tanks and a proton exchange membrane fuel cell for generating of 53 kW (working at 60% of its maximum power). Electrode sizes and the quantity of unit cells proposed in this work were the same as those suggested in the research work by Yang et al., where a phosphoric acid fuel cell was built and studied. The results obtained in that research allowed comparing energy efficiency by scaling a laboratory prototype. The dimensions of the alkaline water electrolysers are the result of satisfying the necessity of fuel and oxidant. The energy consumption results from extrapolating laboratory devices. The integrated power system has a storage tank capacity of 16 h.","palabras_clave":"PEMFC|ALKALINE WATER ELECTROLYSER|INTEGRATED SYSTEM"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40128,"idioma_id":4,"titulo":"Pentose phosphate pathway activity: effect on in vitro maturation and oxidative status of bovine oocytes","resumen":"The relationship between the pentose phosphate pathway (PPP) activity in COCs and oxidative and mitochondrial activity in bovine oocytes was evaluated, with the aim of analyzing the impact of two inhibitors (NADPH, 6-AN) and a stimulator (NADP) of the key enzymes of PPP on the maturation rate, the oxidative and mitochondrial activity, and the mitochondrial distribution in oocytes. The proportion of COCs with measurable PPP activity, (assessed using BCB staining), glucose uptake, lactate production, and meiotic maturation rate diminished when 6-AN was added to the maturation media (p<0.05). The addition of NADPH did not modify glucose uptake and lactate production, while the COC PPP activity and the meiotic maturation rates decreased (p<0.05). The presence of NADP in the maturation medium had no effect on COC PPP activity, glucose uptake, lactate production and meiotic maturation rate. However, in the absence of gonadotrophin supplementation NADP stimulated both glucose uptake and lactate production at the highest concentration tested (p<0.05). NADP did not modify cleavage rate, but decreased blastocyst production (p<0.05). During IVM, oocyte oxidative and mitochondrial activity was observed to increase at 15 and 22 h of maturation, which was also related to a progressive mitochondrial migration. Inhibiting PPP with 6-AN or NADPH led to a reduced oxidative and mitochondrial activity compared with their respective control groups and an inhibition in mitochondrial migration was also observed (p<0.05). Stimulation of the pathway with NADP increased oxidative and mitochondrial activity at 9 h of maturation (p<0.05) and delayed mitochondrial migration. This study shows the significance of altering the PPP activity during bovine oocyte IVM, revealing there is a link between the activity of the pathway and the oxidative status of the oocyte.","palabras_clave":"Glucose metabolism|Mitotracker green|Redox sensor red|Cumulus-oocyte complex"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40129,"idioma_id":4,"titulo":"LUTEAL EXPRESSION OF THYROID HORMONE RECEPTORS DURING GESTATION AND POSTPARTUM IN THE RAT","resumen":"Background:    Progesterone (P4) is the main steroid secreted by the corpora lutea (CL) and is required for successful implantation and maintenance of pregnancy. Although adequate circulating levels of thyroid hormone (TH) are needed to support formation and maintenance of CL during pregnancy, TH signaling has not been described in this gland. We determined luteal thyroid hormone receptor isoforms (TR) expression and regulation throughout pregnancy and under the influence of thyroid status, and in vitro effects of T3 exposure on luteal P4 synthesis.    Methods:    Female Wistar rats were sacrificed by decapitation on days 5 (G5), 10 (G10), 15 (G15), 19 (G19), and 21 (G21) of pregnancy and 2 (L2) postpartum. Hyperthyroidism and Hypothyroidism were induced by daily administration of T4 (0.25 mg\/kg s.c.) or 6-propyl-2-thiouracil (PTU) (0.1 g\/L in drinking water), respectively. Luteal TR expression of RNA was determined using real-time RTPCR, and of protein using Western blot and immunohistochemistry. Primary cultures of luteal cells and of luteinized granulose cells from other rats were used to study in vitro effects of T3 on P4 synthesis. Also, the effect of T3 on basal and stimulated (by luteinizing hormone (LH), prolactin (PRL), and prostaglandin E2 (PGE2)) granulosa cell P4 synthesis was evaluated.      Results    TR&#945;1, TR&#945;2 and TR&#946;1 mRNA were detected in CL of pregnancy. At the protein level, TR&#946;1 was abundantly expressed during gestation reaching a peak on G19 and decreasing afterwards. TR&#945;1 was barely expressed during early gestation, peaked on G19 and diminished thereafter. TR&#946;1 and TR&#945;1 at protein and mRNA level were not influenced by thyroid status. T3 neither modified P4 secretion of the CL of pregnancy nor its synthesis in granulosa-luteinized cell culture.    Conclusions    This study confirms for the first time the presence of TR isoforms in the CL during pregnancy and postpartum, identifying this gland as a TH target during gestation. TR expression is modulated in this tissue in accordance with the regulation of P4 metabolism, and the abrupt peripartum changes suggest a role of TH during luteolysis. However, TH actions on the CL do not seem to be related to a direct regulation of P4 synthesis.","palabras_clave":"Thyroid Hormone Action|Corpus luteum|Pregnancy,|Receptors"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40130,"idioma_id":4,"titulo":"Biological and physicochemical properties of bovine sodium caseinate hydrolysates obtained by a bacterial protease preparation","resumen":"In this work, we aimed at the production of bovine sodium caseinate (NaCAS) hydrolysates by means of an extracellular protease from Bacillus sp. P7. Mass spectrometry was carried out to evaluate peptide mass distribution and identified sequences of peptides with a signal\/noise ratio higher than 10. Antioxidant and antimicrobial properties of hydrolysates were evaluated. An acid-induced aggregation process of the hydrolysates and their corresponding mixtures with NaCAS were also analyzed. The results showed that the enzymatic hydrolysis produced peptides, mostly lower than 3 kDa, with different bioactivities depending on the time of hydrolysis (ti). These hydrolysates lost their ability to aggregate by addition of glucono-delta-lactone, and their incorporation into NaCAS solutions alter the kinetics of the process. Also, the degree of compactness of the NaCAS aggregates, estimated by the fractal dimension of aggregates, was not significantly altered by the incorporation of hydrolysates. However, at higher protein concentrations, when the decrease in pH leads to the formation of NaCAS acid gels, the presence of hydrolysates alters the microstructure and rheological behavior of these gels.","palabras_clave":"BACILLUS SP.P7|BOVINE SODIUM CASEINATE|HYDROLYSATES|BIOACTIVITY|ACID AGREGGATION AND GELATION|MICROSTRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40131,"idioma_id":4,"titulo":"TREATMENT WITH A HYBRID BETWEEN THE SYNAPSIN ABC DOMAINS AND THE B SUBUNIT OF E. COLI HEAT-LABILE TOXIN REDUCES FREQUENCY OF PROINFLAMMATORY CELLS AND CYTOKINES IN CENTRAL NERVOUS SYSTEM OF RATS WITH EAE","resumen":"Multiple sclerosis and its animal model, EAE, are crucially dependent on the invasion of activated autoreactive lymphocytes and blood macrophages into the central nervous system. Proinflammatory mononuclear cells and activated local microglia mediate inflammation, demyelination and axonal damage at the target organ. Previously, we observed that the administration of a hybrid between the synapsin ABC domains and the B subunit of E. coli heat labile-enterotoxin (LTBABC) to rats with EAE ameliorated disease by modulating the peripheral Th1 response to myelin basic protein (MBP). In the present study, we investigated the effect of LTBABC administration on proinflammatory cell frequency into the central nervous system of rats with EAE. Treatment with the hybrid in the inductive phase of EAE attenuated disease severity and diminished histological inflammatory infiltrates and demyelination in the spinal cord of rats with acute EAE. Lower frequencies of infiltrating and local macrophages as well as CD4+ T cells that produce the proinflammatory cytokines IFN-&#947; and IL-17 were found at the target organ. Concomitantly, low levels of INF-&#947; and IL-17 and increased levels of IL-10 were measured in cultures of CNS infiltrating cells and spinal cord tissue. An increased frequency of CD4+CD25+Foxp3 cells was observed at the disease peak and at the beginning of the recovery stage. These results provide further evidence for the immunomodulatory properties of the fusion protein LTBABC in autoimmune demyelinating disease affecting the central nervous system.","palabras_clave":"EAE|Autoimmunity|synapsin|E. coli heat labile toxin"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40132,"idioma_id":5,"titulo":"Análisis de una evaluación por competencias en Matemática mediante Técnicas Multivariadas y Mapas Autoorganizados","resumen":"Se utilizó un examen escrito, del que se obtuvo información cuantitativa del grado de desarrollo de las competencias evaluadas. De este examen se obtuvo además una calificación que resume el desempeño general del estudiante desde el punto de vista de la evaluación tradicional. Se concluyó a través de un Análisis de Componentes Principales (ACP)y de Mapas Autoorganizados de Kohonen, la conformación de dos gradientes que agrupan a diferentes competencias en matemática: aquellas relacionadas con las habilidades de plantear y resolver problemas, pensar matemáticamente y comunicar matemática.","palabras_clave":"Mapas Autoorganizados|Tecnicas Multivariadas|Competencias en Matemática"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40133,"idioma_id":4,"titulo":"The Importance of Having Zinc During In Vitro Maturation of Cattle Cumulus Oocyte Complex: Role of Cumulus Cells.","resumen":"The aim of this study was to investigate the influence of zinc (Zn) on the health of cumulus-oocyte complex (COC) during in vitro maturation (IVM). Experiments were designed to evaluate the effect of Zn added to IVM medium on: DNA integrity, apoptosis, cumulus expansion and superoxide dismutase (SOD) activity of cumulus cells (CC). Also, role of CC on Zn transport during IVM was evaluated on oocyte developmental capacity. DNA damage and early apoptosis were higher in CC matured with 0 &#956;g\/ml Zn compared with 0.7, 1.1 and 1.5 &#956;g\/ml Zn (p  0.05). Superoxide dismutase activity was higher in COC matured with 1.5 &#956;g\/ml Zn than with 0 &#956;g\/ml Zn (p  0.05). Blastocyst rates were significantly higher in COC than in DO + CC and DO with the addition of 1.5 &#956;g\/ml Zn during IVM (p < 0.01). Blastocyst quality was enhanced in COC and DO + CC compared with DO when Zn was added to IVM medium (p < 0.001). The results of this study indicate that Zn supplementation to IVM medium (i) decreased DNA damage and apoptosis in CC; (ii) increased SOD activity in CC; (iii) did not modify cumulus expansion and cleavage rates after in vitro fertilization; (iv) improved subsequent embryo development up to blastocyst stage; and (v) enhanced blastocyst quality when CC were present either in intact COC or in coculture during IVM.","palabras_clave":"ZINC|CUMULUS-OOCYTE COMPLEX|IN VITRO MADURATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40134,"idioma_id":4,"titulo":"Lack of contextual-word predictability during reading in patients with mild Alzheimer disease","resumen":"Neuropsychologia. 2014 Sep;62:143-51. doi: 10.1016\/j.neuropsychologia.2014.07.023.   Lack of contextual-word predictability during reading in patients with mild Alzheimer disease.  Fernández G, Manes F, Rotstein NP, Colombo O, Mandolesi P, Politi LE, Agamennoni O.    Abstract  In the present work we analyzed the effect of contextual word predictability on the eye movement behavior of patients with mild Alzheimer disease (AD) compared to age-matched controls, by using the eyetracking technique and lineal mixed models. Twenty AD patients and 40 age-matched controls participated in the study. We first evaluated gaze duration during reading low and highly predictable sentences. AD patients showed an increase in gaze duration, compared to controls, both in sentences of low or high predictability. In controls, highly predictable sentences led to shorter gaze durations; by contrary, AD patients showed similar gaze durations in both types of sentences. Similarly, gaze duration in controls was affected by the cloze predictability of word N and N+1, whereas it was the same in AD patients. In contrast, the effects of word frequency and word length were similar in controls and AD patients. Our results imply that contextual-word predictability, whose processing is proposed to require memory retrieval, facilitated reading behavior in healthy subjects, but this facilitation was lost in early AD patients. This loss might reveal impairments in brain areas such as those corresponding to working memory, memory retrieval, and semantic memory functions that are already present at early stages of AD. In contrast, word frequency and length processing might require less complex mechanisms, which were still retained by AD patients. To the best of our knowledge, this is the first study measuring how patients with early AD process well-defined words embedded in sentences of high and low predictability. Evaluation of the resulting changes in eye movement behavior might provide a useful tool for a more precise early diagnosis of AD.","palabras_clave":"EYE TRACKER|EYE MOVEMENTS|ALZHEIMER DISEASE|READING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40135,"idioma_id":5,"titulo":"Modificación antrópica del paisaje durante el Holoceno Tardío: las construcciones monticulares en el  delta Superior del río Paraná.","resumen":"Las construcciones monticulares en tierra constituyen uno de los registros característicos de la arqueología de las Tierras Bajassudamericanas. La presencia de estos rasgos en el Delta del río Paraná y el registro cultural preservado en el interior de lasmismas, captó la atención académica desde finales del siglo XIX. Desde ese tiempo y hasta el presente, la discusión en cuantoa la génesis de los denominados ?tumulus?, ?cerritos?, ?montículos? es objeto de debate en la comunidad arqueológica. Losdiferentes enfoques varían desde quienes consideran que son el resultado del desarrollo, sobre zonas naturalmente elevadas,de actividades domésticas y funerarias vs. los que proponen una génesis totalmente antrópica. Para discriminar la intervenciónhumana en el origen y evolución monticular, presentamos los resultados de los análisis estratigráficos, sedimentológicosy biocomposicionales que han permitido reconocer claras diferencias texturales, mineralógicas y de componentes biosilíceosde los sedimentos monticulares respecto de los obtenidos de los estratos naturales, superficiales y subsuperficiales, donde éstasse erigen. El estudio realizado permite proponer que durante el Holoceno tardío las sociedades indígenas que ocuparon el áreadeltaica, seleccionaron, modificaron y adicionaron a los fangos naturalmente disponibles, fragmentos de cerámicas, materialesorgánicos y tierras quemadas para elevar y consolidar estructuras en tierra","palabras_clave":"Geoarqueología, Holoceno tardío|Delta del Paraná,|montículos antrópicos | Holoceno tardío"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40136,"idioma_id":5,"titulo":"Utilizacion de hierro como terapia preventiva de anemia ferropenica en niños menores de 2 años","resumen":"Introducción: La suplementación con hierro (Fe) en niños es una estrategia de eficacia demostrada para prevenir la anemia ferropénica, aunque su prevalencia sigue siendo elevada en Argentina. Objetivo: Evaluar el patrón de prescripción de hierro en niños en dos Centros de Atención Primaria de la Salud (CAPS) de la ciudad de Corrientes. Material y Métodos: Estudio descriptivo, transversal,enmarcado dentro de los Estudios de utilización de medicamentos. Se incluyeron todos los niños de 2 a 23 meses que concurrieron a dos CAPS (período 2012-2013). Se recabaron datos a través de encuestas realizadas a los padres y de revisión de las historias clínicas. Resultados: total de niños que consultaron: 250 (media de edad: 12,4 meses). No recibían Fe 182 (73%): 137 (75%) por faltade prescripción médica, 32 (18%) por prescripción inadecuada (falta de especificación al familiar del tiempo de duración del tratamiento), 9 (5%) por eventos adversos y 4 (2%) por mitos, factores culturales. Duración media de la ferroprofilaxis fue de 66 días. Recibieron una dosis de Fe inadecuada (no acorde a peso, finalidad de tratamiento, a la consideración de la presencia de factores de riesgo para anemia) 6 pacientes (9%). El 67 % de los niños que recibía sulfato ferroso consumía mate cocido y otras infusiones, el 33% gaseosas (inhibidores de la absorción del hierro). Factores facilitadores de la absorción de hierro (cítricos y carnes): administrados en el 57% de los niños. Conclusiones: A pesar del conocimiento por parte de pediatras de las normas de suplementación con Fe en niños, existe aún bajo porcentaje de prescripción y adherencia al tratamiento por lo que se debería estimular la utilización de este mineral de eficacia demostrada.","palabras_clave":"FERROPROFILAXIS|PREVENCION|ANEMIA|FARMACOEPIDEMIOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40137,"idioma_id":5,"titulo":"El emprendedor como fuerza social productiva en el desarrollo regional","resumen":"Partiendo de la caracterización del emprendedor, por medio de una interpretación semiótica del cuerpo teórico, se va constituyendo una concepción de éste a través de su rol en la economía regional del Partido de La Matanza; para lo cual se precisa: constituir desde la semiótica una nueva propiedad propedéutica para este estudio, y para futuros abordajes metodológicos de investigación y de enseñanza sobre emprendedores y emprendedorismo; esclarecer la esencia del «ser emprendedor»; e indagar sobre el significado del «tener que emprender» una organización de factores de la producción que conlleve el compromiso del «deber ser» un agente económico que contribuya a la equidad social a través de la difusión de los impulsos económicos por medio de las cadenas cooperativas de valor.","palabras_clave":"Desarrollo económico y social|Desarrollo Participativo|Emprendedorismo|Emprendedor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40138,"idioma_id":4,"titulo":"Alternaria keratitis and hypopyon after clear-cornea phacoemulsification","resumen":"We report a case of Alternaria keratitis and hypopyon following clear-corneal cataract surgery. A 66-year-old woman presented with a painful red left eye several months after uneventful self-sealing clear-corneal phacoemulsification that was unresponsive to prolonged treatment with topical\/oral quinolones and topical corticosteroids. A full-thickness stromal white dense infil- trate in the area of the intrastromal tunnel incision and a 2.0 mm hypopyon were observed. Culture from corneal scrapings revealed Alternaria species. Treatment included topical and subconjunc- tival injections of amphotericin-B (5 mg\/mL) and 200 mg of oral ketoconazole. Complete resolu- tion of the corneal infiltration and hypopyon was observed after 30 days of treatment, with no recurrence during 6 years of follow-up. To our knowledge, this is the first report of Alternaria species keratitis complicating self-sealing clear-corneal cataract surgery. Topical and subconjunc- tival injections of amphotericin-B and oral ketoconazole were effective in resolving the corneal abscess and anterior chamber inflammatory reaction.","palabras_clave":"conjunctival squamous ,, |cell carcinoma| surgical excision|cryotherapy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40139,"idioma_id":4,"titulo":"Vortex pinning vs superconducting wire network: origin of periodic oscillations induced by applied magnetic fields in superconducting films with arrays of nanomagnets","resumen":"Hybrid magnetic arrays embedded in superconducting films are ideal systems to study the competition between different physical (such as the coherence length) and structural length scales such as are available in artificially produced structures. This interplay leads to oscillation in many magnetically dependent superconducting properties such as the critical currents, resistivity and magnetization. These effects are generally analyzed using two distinct models based on vortex pinning or wire network. In this work, we show that for magnetic dot arrays, as opposed to antidot (i.e. holes) arrays, vortex pinning is the main mechanism for field induced oscillations in resistance R(H), critical current Ic(H), magnetization M(H) and ac-susceptibility &#967; ac(H) in a broad temperature range. Due to the coherence length divergence at Tc, a crossover to wire network behaviour is experimentally found. While pinning occurs in a wide temperature range up to Tc, wire network behaviour is only present in a very narrow temperature window close to Tc. In this temperature interval, contributions from both mechanisms are operational but can be experimentally distinguished.","palabras_clave":"SUPERCONDUCTIVITY|VORTEX|FILMS|NANOTECHNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40140,"idioma_id":5,"titulo":". Bloqueo paravertebral de los nervios espinales tora&#769;cicos como aporte analge&#769;sico para una lobectomi&#769;a pulmonar en un canino","resumen":"lung lobectomy in a dog.Case summary: Female dog, 10 years old and weighing 22 kg, underwent a left lung lobectomy for the resection of several lung tumors. As the analgesic protocol for the intraoperative period, a nerve- stimulationguided thoracic paravertebral block of seven spinal nerves(T2-T8) was performed. Bupivacaine 0.5% 0.05 ml kg -1 was administered for each nerve block. Thoracotomy was performed at the 6thleft intercostal space. At the end of the surgical procedure, 0.15 mL cm-1 of occipito-coccygeal length of an anaesthetic solution of bupivacaine 0.125% with morphine 0.1 mg kg was administered at the lumbosacral epidural space. This report demonstrated the adequate analgesic effect proposed by the thoracic paravertebral block during the intraoperative period.New information. This is the first report that demonstrates the efficacy of the thoracic paravertebral block as the sole analgesic protocol for lung lobectomy in dogs.Keywords: paravertebral, lobectomy, nerve stimulation, bupivacaine, dogs.","palabras_clave":"paravertebral, |lobectomy, |nerve stimulation, |bupivacaine."},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40141,"idioma_id":4,"titulo":"Emergence of genetically unrelated NDM-1-producing Acinetobacter pittii strains in Paraguay","resumen":"The New Delhi metallo-b-lactamase (NDM-1) was initially identified in Escherichia coli and Klebsiella pneumoniae isolates in Sweden, from a patient previously hospitalized in India.1 To date, NDM producers in Latin America have been scarce, and associated with species of Enterobacteriaceae from Guatemala, Mexico, Colombia and Brazil, although in Honduras it was reported in Acinetobacter baumannii. Here, we report two genetically unrelated NDM-1-producing Acinetobacter pittii isolates identified in Paraguay.","palabras_clave":"CARBAPENEMASES|RESISTANCE|PAEDIATRIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40142,"idioma_id":4,"titulo":"Effect of association of yeast (S. cerevisiae) with threonine in broilers feeding","resumen":"Yeast (Saccharomyces cerevisiae) alone, replacing part of premix or associated with E vitamin is known for its positive effects on productive performance and carcass quality. Threonine, increase the intestinal mucosae health, improving absorption capacities. The objective was to determinate the effect of Saccharomyces cerevisiae associated with threonine in diets, on productive, carcass quality and gut histo-morphometric variables in broilers. Hundred Ross male broilers were used, from birth to 43 days old, distributed in 20 pens, 5 replicated\/treatment with 5 chicks\/replicated. The diets were: D1: commercial type covering the minimum requirements for threonine, D2: D1 plus 0.5% yeast, D3: D1 plus 30% more than minimum threonine requirement; D4: D3 plus 0.5% yeast. The production variables Average Daily Weight Gain (ADWG) (g\/bird\/day), Average Daily Consumption (ADC) (g\/bird\/day), and Feed Conversion Ratio (FCR)), carcass quality (Carcass Performance (CP)(%), Breast Weight (BW)(g), Thigh Weight (TW)(g) and Abdominal Fat Weight (AFW)(g)) and gut histo-morphometry High Villi (HV,ì), Crypt Depth (CD,ì) and Villi Area (VA, ì2) were evaluated. The production and carcass quality data were analyzed by ANOVA, while gut histo-morphometric data were analyzed by nested design with two factors and LSD test. In all case p± 2.2 g) than D3 (67.74 ± 2.2 g); D4 broiler demonstrated significantly (p± .04) than D2 and D3 chickens (1.92 ± .07, 1.88 ± .03), respectively. Also, D4 broilers deposited significantly (p .05) more BW (850.5 ± 64.6 g) that D3 chickens (750.5 ± 69.8 g) and significantly (p± 10.7 g) that D1 broilers (48.3 ± 7.4 g). About gut histomorphometry, D4 group have significantly (p±  33.09 ì ; VA:160300 ± 36399.66 ì2) than D1 chickens (CD:139.22 ±  57.70 ì ; VA:118007.1 ± 40686.11 ì2¦). Also, the chickens receiving threonine (D3 and D4) had higher cell sparing and high number goblet cells producing mucus in the villus. It be concluded that the combination of yeast and threonine improved in part, the productivity in broilers received them.","palabras_clave":"S. CEREVISIAE|THREONINE|BROILERS|CARCASS QUALITY|INTESTINAL HISTO-MORPHOMETRY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40143,"idioma_id":5,"titulo":"UN METODO EFICIENTE PARA LA SUSTRACCION DE FONDO EN VIDEOS USANDO GPU","resumen":"La sustracción de fondo es una técnica ampliamente utilizada para detectar objetos en movimiento a partir de cámaras estáticas. En el campo de la vídeo-vigilancia, es una técnica indispensable, ya que permite discriminar rápidamente cuando ha surgido un evento y permite a su vez realizar algún tipo de estudio de movilidad. En los últimos años, se han propuesto muchos métodos con diferentes fortalezas y requerimientos para realizar la sustracción de fondo. Uno de los métodos más novedosos es el Visual Background Extractor (ViBe), el cual utilizando análisis estocástico multimodelo permite discriminar objetos del fondo con una alta tasa de confianza. En este trabajo se propone una variante de este algoritmo para el estudio de objetos en situaciones particulares a partir de videos de vigilancia. Dado que se desea trabajar con videos de alta resolución, se presenta una implementación en GPU utilizando OpenCL para lograr un análisis en tiempo real. Presentamos la funcionalidad en casos de estudios típicos en para este área.","palabras_clave":"Procesamiento de imágenes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40144,"idioma_id":4,"titulo":"Methodology and measurement setup for analog-to-digital converter post-compensation","resumen":"We present a methodology for nonlinearity compensation  amenable to a wide variety of analog-to-digital converters  (ADCs). To that purpose, a postcompensation scheme for a  commercial ADC is presented and two compensator models  are considered: 1) the memory polynomial (MP) and 2) the  modified generalized MP. Since the proposed method does not  use any information about the compensated architecture, it can  be applied to different ADC designs. Furthermore, we address  the measurement and characterization setup of the device under  test by making a study of the quality of the signals involved  to verify the improvement obtained. The issue of the training  sequences required by the proposed compensation method is also  addressed in detail. Despite the common use of a single training  signal, we propose to use several sinusoids in the bandwidth of  interest. With this, it is possible to show that the generalization  properties of the estimated postcompensator are greatly enhanced  compared with the case of a single sinusoid training sequence.  As verified by the measurements, considerable gain in accuracy  can be obtained using the proposed methodology. In particular,  a 10-dB increment in spurious free dynamic range is obtained  using the proposed postcompensators over the complete Nyquist  frequency band.","palabras_clave":"ADC CHARACTERIZATION|ADC COMPENSATION|MEASUREMENTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40145,"idioma_id":4,"titulo":"Model uncertainty estimation of a solid oxide fuel cell using a Volterra-type model","resumen":"The dynamic nature of solid oxide fuel cells (SOFC) shows that they can be conceived as multi-input multi-output nonlinear processes. Aiming at  dynamic simulation and control, this work presents a modeling study of a SOFC stack following a gray-box modeling approach. For such purpose, a Modified Generalized Memory Polynomial (MGMP) model is identified based only on input?output data of the system.Additionally, dedicated estimation is dealt with in order to cope with the presence of possible model uncertainty. Simulation results are given to illustrate the quality of the obtained model which is compared with other modeling approaches.","palabras_clave":"Identification|Uncertainty estimation|Solid oxide fuel cell"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40146,"idioma_id":5,"titulo":"Riesgo para la población rural en zonas con alto contenido de arsénico en agua","resumen":"El arsénico (As) es un tóxico natural presente en aguas subterráneas y superficiales. En este trabajo se estimó el riesgo por ingesta de agua subterránea con elevadas concentraciones de As para pobladores rurales bonaerenses. Además se consideró una fuente adicional de exposición a la presencia de As en tejidos blandos del pejerrey (Odontesthes bonariensis), quees la especie nativa de mayor importancia comercial. La concentración de As se determinó por espectroscopía de emisión atómica por plasma de acoplamiento inductivo (ICP-OES).En las muestras de agua subterránea las concentraciones se hallaron en el rango de <10-170 µg\/l, mientras que en músculos de peces estuvo comprendida entre 0,29-8,41 µg\/g y en hígado entre 0,24-8,98 µg\/g (en peso seco). El hidroarsenicismo crónico regional endémico Argentino (HACREA), enfermedad que se origina por el consumo de cantidades variables de As en un largo período de tiempo, genera diferentes afecciones de piel. El riesgo estimado por ingesta de agua subterránea en todas las localidades estudiadas superó el valor aceptado de riesgo individual máximo (10-5), según la Agencia de Protección Ambiental de losEstados Unidos (USEPA). Los niveles de As hallados en tejidos de peces, sugieren que existiría transferencia de este elemento desde el agua a los distintos órganos, que podría resultar perjudicial para el consumo humano.","palabras_clave":"arsenico|agua|riesgo |buenos aires"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40147,"idioma_id":4,"titulo":"Arsenic, Fluoride and Vanadium in surface water (Chasicó Lake, Argentina)","resumen":"Chasicó Lake is the main water body in the southwest of the Chaco-Pampean plain. It shows some differences from the typical Pampean shallow lakes, such as high salinity and high arsenic and fluoride levels. The aim of this paper is to analyze the trace elements [arsenic (As), fluoride (F-) and vanadium (V)] present in Chasicó Lake. Surface and groundwater were sampled in dry and wet periods, during 2010 and 2011. Fluoride was determined with a selective electrode. As and V were determined by Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES). Significant correlation in surface water was only found for As and F- (r=0.978, p<0.01). The As, F- and V concentration values were higher and more widely dispersed in surface water than in groundwater, as a consequence of evaporation. The fact that these elements do not correlate in surface water may also indicates that groundwater would not be the main source of origin of As, F- and V in surface water. The origin of these trace elements is from volcanic glass from Pampean loess. As, F- and V concentration were higher than in national and international guideline levels for the protection of aquatic biota. Hence, this issue is relevant since the silverside (Odontesthes bonariensis) is the most important commercial species in Chasicó Lake. This fish is both consumed locally and exported to other South-American countries through commercial and sport fishing.","palabras_clave":"arsenic|fluoride|surface water|Chasico lake|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40148,"idioma_id":4,"titulo":"Chemical Composition of Oleoresins from Berries of Schinus molle L. Grown in Buenos Aires Province (Argentina)","resumen":"In this study, the chemical composition of the oleoresins   prepared from fresh and 1 year stored (-18°C) berries of Argentine Aguaribay   trees was established by GC-MS. The fresh oil was found to contain mainly 40%   of monoterpene and sesquiterpene hydrocarbons and 34% of sesquiterpene alcohols   and related compounds (caryophyllene oxide and guaiol acetate). Principal individual   compounds were guaiol acetate (11.96%), &#948;-cadinene (8.64%) and &#947;-caryophyllene   (7.12%). The oleoresin obtained from stored berries contained 71% of monoterpene   and sesquiterpene hydrocarbons and 16.5% of sesquiterpene alcohols and related   compounds. More abundant individual compounds were &#947;-caryophyllene (18.84%),   &#947;-muurolene (16.23%) and bicyclogermacrene (13.54%). The observed differences   in composition could be mainly attributed to dehydration of alcohols to some   structurally related alkenes occurred into the stored berries. Hydrocarbon composition   is further discussed in relation to the previously reported antibacterial activity   of the oleoresin.","palabras_clave":"BERRIES|AGUARIBAY|OLEORESIN|CHEMICAL COMPOSITION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40149,"idioma_id":5,"titulo":"Educación Superior y Jóvenes. Elecciones, experiencias y trayectorias","resumen":"En este artículo se presentan resultados generales de tesis de maestrías y doctorado que indagaron sobre problemas vinculados con estudiantes de la UNVM. Son conclusiones provisorias sobre las razones e intereses en la elección de carrera universitaria en ingresantes 2006 y la permanencia o no de los mismos a dos años (2008) del ingreso (Aimino. 2012); al capital cultural y experiencias estudiantiles de jóvenes ingresantes (Martínez. 2013) y sobre las experiencias, trayectorias académicas y estrategias laborales de estudiantes de la educación superior que deconstruyen el programa moderno de la movilidad social (Coppari. 2014). Se reconocen en estos trabajos datos y sentidos que son antecedentes teóricos de una investigación en curso en el ámbito del Instituto Académico Pedagógico de Ciencias Humanas, de la Universidad Nacional de Villa María, que tiene como propósito central conocer las características sociodemográficas y socioculturales de los ingresantes a la UNVM, en el ciclo lectivo 2014.","palabras_clave":"Educación Superior|Jóvenes|Trayectorias académicas|Trayectorias laborales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40150,"idioma_id":4,"titulo":"Alfalfa snakin-1 prevents fungal colonization and probably coevolved with rhizobia","resumen":"Background:The production of antimicrobial peptides is a common defense strategy of living cells against a wide  range of pathogens. Plant snakin peptides inhibit bacterial and fungal growth at extremely low concentrations.  However, little is known of their molecular and ecological characteristics, including origin, evolutionary equivalence,  specific functions and activity against beneficial microbes. The aim of this study was to identify and characterize  snakin-1 from alfalfa (MsSN1).  Results:Phylogenetic analysis showed complete congruence between snakin-1 and plant trees. The antimicrobial  activity ofMsSN1 against bacterial and fungal pathogens of alfalfa was demonstratedin vitro andin vivo. Transgenic  alfalfa overexpressingMsSN1showed increased antimicrobial activity against virulent fungal strains. However,MsSN1  did not affect nitrogen-fixing bacterial strains only when these had an alfalfa origin.  Conclusions:The results reported here suggest that snakin peptides have important and ancestral roles in land  plant innate immunity. Our data indicate a coevolutionary process, in which alfalfa exerts a selection pressure for  resistance to MsSN1 on rhizobial bacteria. The increased antimicrobial activity against virulent fungal strains without  altering the nitrogen-fixing symbiosis observed inMsSN1-overexpressing alfalfa transgenic plants opens the way to  the production of effective legume transgenic cultivars for biotic stress resistance.  Keywords:Antimicrobial peptides, Alfalfa, Evolution, Land plants, Innate immunity, Snakin","palabras_clave":"SNAKIN|ALFALFA |RIZOBIA|PEPTIDOS ANTIMICROBIANOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40152,"idioma_id":4,"titulo":"In vitro equine embryo production using air-dried spermatozoa, with different activation protocols and culture systems","resumen":"The aim of this work was to evaluate the use of air-dried spermatozoa for in vitro production of equine embryos and verify if sperm extract activation and in vivo culture improve in vitro embryo production. Cooled spermatozoa (control) and air-dried spermatozoa stored for 2, 14 or 28 days were used for ICSI sperm extract, or ionomycin was used for oocyte activation, and embryos were in vitro or in vivo (in mare´s oviduct) cultured for 7 days. With in vitro culture, cleavage rate was higher when activating with sperm extract (P  0.05). Blastocysts were obtained with cooled spermatozoa, and morulae were achieved using in vivo culture with 28-day storage spermatozoa and ionomycin-activated oocytes. When in vivo culture was performed, sperm DNA fragmentation was assessed using the sperm chromatin dispersion test and did not show statistical correlation with cleavage nor embryo recovery rates. In conclusion, equine embryos can be produced using air-dried spermatozoa stored for several weeks. Sperm extract activation increased cleavage rates but did not improve embryo development. In vivo culture allowed intrauterine stage embryos to be achieved.","palabras_clave":"AIR-DRIED SPERMATOZOA|EQUINE|ICSI|IN VIVO CULTURE|SPERM EXTRACT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40153,"idioma_id":4,"titulo":"Hydrogen energy vector: Demonstration pilot plant with minimal peripheral equipment","resumen":"In this work we develop and build a demonstrative pilot plant of the hydrogen energy vector that includes: energy conversion by a photovoltaic panel, production of hydrogen by electrolysis of water, low pressure storage of gases and use of a stack of proton exchange membrane fuel cells. The system was designed without peripheral equipment in order to minimize energy losses. This improvement is achieved by means of suitable modification of the different elements involved. This demonstrative pilot plant appears to be useful for low and medium energy consumptions (for example, mountain huts and military shelters).","palabras_clave":"Hydrogen energy|Energy conversion|Photovoltaic panel|Water electrolysis|Hydrogen fuel cell"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40154,"idioma_id":4,"titulo":"Seabird and dolphin associations: do seabirds benefit from feeding in association with dusky dolphins in Patagonia?","resumen":"The objective of this study was to describe associations between several species of seabirds and dusky dolphins. We investigated during what dolphin? activities seabirds were most commonly associated and the size of flock in relation to the number of dolphins in a group. Since both seabirds and dolphins may display different feeding strategies, we also investigated if benefits differed among seabird species. Data were collected in Golfo Nuevo (42º20´S, 65º00´W) onboard of a research vessel from 2001 to 2008. A total of 224 mixed groups of seabirds were encountered during this study. The seabird-dolphin associations were mainly observed during dusky dolphin surface feeding. Shearwaters and kelp gulls were mainly observed in flocks that were associated with dolphins, while Magellanic penguins and cormorants were mainly observed without dolphins. Seabirds may be conditioned to the foraging strategy of dolphins, since birds are associated with dolphins only during dolphin surface feeding. This association probably helped seabirds to find prey, but there were no obvious benefits to dolphins.","palabras_clave":"COMMENSALISM|FEEDING ASSOCIATION|SEABIRD-CETACEAN INTERACTION|PENINSULA VALDÉS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40155,"idioma_id":4,"titulo":"Photodynamic Antibacterial Chemotherapy (PACT) Against Staphylococcus aureus and Escherichia coli Using Gold Nanoparticles and LED?s Irradiation","resumen":"Gold nanoparticles synthesized through sodium citrate (A-AuNPs) and sodium borohydrade (B-AuNPs) reduction of Au3+ and a photochemically initiated method (C-AuNPs) were tested for possible application in Photodynamic Antibacterial  Chemotherapy. None of them presented inhibitory activity against bacterial suspensions in dark conditions using the cylinders inhibition method; however, a total inhibition of Staphylococcus aureus ATCC 29213 and an extended-spectrum  beta-lactamases-producing Escherichia coli ATCC 25922 growth were observed when incubated with 2 mM B-AuNPs and irradiated with LEDs at 525 nm for 12 h. Characterization of the interaction between S.aureus and B-AuNPs was  demonstrated through an optimized procedure for TEM. These results probe that B-AuNPs have a good potential as photosensitizers for PACT.","palabras_clave":"Gold Nanoparticles|Staphylococcus aureus|Escherichia coli|Photodynamic Antibacterial Chemotherapy"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40156,"idioma_id":5,"titulo":"Comparación de Modelos de Calidad, Factores y Métricas en el Ambito de la Ingenieria de Software","resumen":"Existen diferentes enfoques de desarrollo de software, en su mayoría priorizan la calidad en el proceso y el producto obtenido. Para poder lograr esto es importante el uso de modelos de calidad apropiados para cada metodología. Estos modelos de calidad presentan factores e indicadores que describen las características del software y sus relaciones y pueden ser adaptaciones de otros o creados tomando como base los estándares existentes.Este trabajo describe y analiza algunos modelos de calidad desarrollados para las metodologías de desarrollo de software orientada a objetos, a componentes, a aspectos y los métodos ágiles, realiza una comparación según los criterios, factores y características que lo componen, niveles de abstracción y métricas para llevar a cabo la medición.","palabras_clave":"Calidad de Software|Métricas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40157,"idioma_id":5,"titulo":"Implementación de una Formulación de Bajo Orden para Materiales Incompresibles en Hemodinámica","resumen":"Es un hecho conocido que las formulaciones de elementos finitos de bajo orden presentan comportamientos anómalos al modelar materiales cercanos al límite de la incompresibilidad. En tales situaciones, aparecen oscilaciones espurias y locking como consecuencia de la incapacidad de este tipo de elementos para representar adecuadamente campos que preserven el volumen. Aun así, suele preferirse el uso de estos elementos en problemas a gran escala debido a su simplicidad y bajo coste computacional.Muchas alternativas vienen siendo propuestas para adecuar estas formulaciones en torno al límite de la incompresibilidad. En problemas geométricamente lineales existen diversas formulaciones que funcionan exitosamente; sin embargo en regímenes no lineales la incompresibilidad es considerablemente más demandante, y el desarrollo de elementos eficientes y robustos no es directo de ninguna manera.Teniendo en cuenta las consideraciones anteriores, se analiza el comportamiento numérico del elemento denominado F-bar. Este elemento es utilizado en varios casos de prueba con soluciones conocidas en la literatura, poniéndose en evidencia que presenta buen desempeño para la captura de los campos dedesplazamientos, pero mostrando modos espurios en los campos de presiones. Finalmente se aplica esta formulación en un problema de hemodinámica computacional: simulación de un segmento de pared arterial carótida humana bajo la aplicación de presión interna.","palabras_clave":"FSI|formulación ALE|Hemodinámica|ecuaciones de Navier-Stokes"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40158,"idioma_id":4,"titulo":"Microbiological bioassay using Bacillus pumilus to detect tetracycline in milk","resumen":"The tetracyclines (TCs) are widely used in the treatment of several diseases of cattle and their residues may be present in milk. To control these residues it is necessary to have available inexpensive screening methods based on innocuous bacteria. The purpose of this study was to design a bioassay of microbiological inhibition in microtiter plates with spores of Bacillus pumilus to detect TCs at concentrations the Maximum Residue Limits (MRLs). Several complementary experiments were performed to design the bioassay. In the first study, we determined the concentration of spores that produce a change in the bioassay?s relative absorbance in a short time period. Subsequently, we assessed the concentration of chloramphenicol required to decrease the detection limit (DL) of TCs at MRLs levels. Thereafter, specificity, DL and cross-specificity of the bioassay were estimated. The most appropriate microbiological inhibition assay had a B. pumilus concentration of 1.6 109 spores\/ml, fortified with 2500 µg\/l of chloramphenicol (CAP) in Mueller Hinton culture medium using brilliant black and toluidine blue as redox indicator. This bioassay detected 117 µg\/l of chlortetracycline, 187 µg\/l of tetracycline and 142 µg\/l of oxytetracycline by means of a change in the indicator?s colour in a period of 5 hours. The method showed good specificity (97.9%) which decreased slightly (93.3%) in milk samples with high somatic cell counts (> 250,000 cells\/ml). Furthermore, other antimicrobials studied (except neomycin) must be present in milk at high concentrations (from >5 to >100 MRLs) to produce positive results in this assay, indicating a low cross specificity.","palabras_clave":"Milk|Tetraciclyne|Bioassay|Screening test"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40159,"idioma_id":4,"titulo":"Insight into the effect of the vasopressin analog desmopressin on lung colonization by mammary carcinoma cells in BALB\/c mice","resumen":"BACKGROUND\/AIM:     Desmopressin   (dDAVP) is a synthetic peptide analog of vasopressin with antidiuretic   and hemostatic properties. Recent experimental evidence have suggested   that dDAVP can inhibit metastasis formation by agonist action on V2   vasopressin receptors present in both tumor and endothelial cells. We   have examined the kinetics of dDAVP effect during metastatic   colonization and its potential association with hemostasis.    MATERIALS AND METHODS:     The   experimental metastasis assay was performed by injecting F3II mammary   carcinoma cells into the lateral tail vein of syngeneic female BALB\/c   mice.    RESULTS:     Clinically   relevant doses of dDAVP (0.3 to 2 &#956;g\/kg intravenously (i.v.)) produced a   dose-dependent inhibition in the formation of lung nodules when   administered during the first 24 hours after F3II tumor cell injection.   The hemostatic agent tranexamic acid (10 mg\/kg, i.v.) had no effect on   metastasis formation in the same experimental conditions, while the   anticoagulant enoxaparin (1 mg\/kg, subcutaneously (s.c.)) did not modify   the antimetastatic action of dDAVP. In vitro, dDAVP had a strong   inhibitory effect on F3II cell colony formation.    CONCLUSION:     dDAVP interferes with early metastatic disease, and direct association of this effect with hemostatic mechanisms is unlikely.","palabras_clave":"DESMOPRESSIN|HEMOSTATIC PROPERTIES|BREAST CANCER"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40160,"idioma_id":6,"titulo":"La ciudad puerto como fundamento identitario de los actores del desarrollo institucional y económico regional frente las grandes crisis internacionales. El caso de Rosario (Argentina), 1890-2001","resumen":"Revista indizada en ERIH PLUS, DOAJ, Hapi Online, Latindex, Revues.org, INSHS-CNRS, EHESS, REDIAL\/CEISAL, INIST, e-Revista Biblioteca Virtual CSIC, Catálogo CSIC, DIALNET, BASE, Google Scholar, EZB, JournalSeek, SUDOC, Cibera , DHistória. History Journals Index, Biblioteca Virtual Miguel de Cervantes, AperTO, HCERS (Aeres), AtoZ (EBSCO), 360 Core (Serials Solutions), SFX (Exlibris), LinkSolver (Ovid), EBSCO Discovery Service, Summon (Proquest), Primo Central (Exlibris). El Programa Internacional Gobernanza Puertos del Atlántico convocó a los asistentes al coloquio que celebró en Lisboa en 2014, referido a los puertos y las dinámicas económicas, a participar de un dossier sobre la temática a publicar en la revista Mundo Nuevo Nuevos Mundos. (Se adjunta certificado de aceptación del artículo). Abstrac. La ciudad de Rosario se encuentra en el centro de uno de los complejos portuarios más importantes del cono sur, -sobre el río Paraná, en el Eje fluvial de la Cuenca del Plata-, en una de las regiones del mundo con mayor capacidad exportadora de cereales. La capacidad de interrelación y organización de sus redes económicas, sociales y culturales habrían compensado, en parte, la dependencia política que la sujetó a dos ciudades puertos que compitieron con ella por la misma zona de influencia: Buenos Aires (capital de la República) y Santa Fe (capital de la provincia homónima que integra Rosario). La ponencia analiza la incidencia de la dinámica de la ciudad puerto de Rosario en la formulación de políticas de modernización estatal, y el desarrollo regional, con especial referencia a la postura de su elite dirigente ante los cambios políticos y económicos que se sucedieron a partir de los conflictos bélicos y las crisis económicas mundiales y el apego a un discurso histórico político relacionado con el deber ser ciudad puerto. La investigación, realizada sobre fuentes de época, incluye un estado del arte, resultados de experiencias de campo relacionadas con la comunicación de la identidad portuaria y una propuesta historiográfica.","palabras_clave":"HISTORIA|PUERTO|ROSARIO|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40161,"idioma_id":4,"titulo":"Modeling IoT-Based Solutions Using Human-Centric Wireless Sensor Networks","resumen":"The Internet of Things (IoT) has inspired solutions that are already available for addressing problems in various application scenarios, such as healthcare, security, emergency support and tourism. However, there is no clear approach to modeling these systems and envisioning their capabilities at the design time. Therefore, the process of designing these systems is ad hoc and its real impact is evaluated once the solution is already implemented, which is risky and expensive. This paper proposes a modeling approach that uses   human-centric wireless sensor networks to specify and evaluate models of IoT-based systems at the time of design, avoiding the need to spend time and effort on early implementations of immature designs. It allows designers to focus on the system design, leaving the implementation decisions for a next phase. The article illustrates the usefulness of this proposal through a running example, showing the design of an IoT-based solution to support the first responses during medium-sized or large urban incidents. The case study used in the proposal evaluation is based on a real train crash. The proposed modeling approach can be used to design IoT-based systems for other application scenarios, e.g., to support security operatives or monitor chronic patients in their homes.","palabras_clave":"INTERNET OF THINGS|MODELING APPROACH|HUMAN-CENTRIC WIRELESS SENSOR NETWORKS|EMERGENCY RESPONSE|AMBIENT INTELLIGENCE|INFORMATION SHARING|URBAN EMERGENCIES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40162,"idioma_id":4,"titulo":"Factors associated with healthcare avoidance among transgender women in Argentina","resumen":"IntroductionTransgender (TG) women in many settings continue to contend with barriers to healthcare, including experiences of stigma and discrimination. Argentina has a universal health care system and laws designed to promote healthcare access among TG women. However, little is known about barriers to healthcare access among TG women in this setting. The aim of this study was to explore individual, social-structural and environmental factors associated with healthcare avoidance among TG women in Argentina.MethodsData were derived from a 2013 nation-wide, cross-sectional study involving TG women in Argentina. We assessed the prevalence and factors associated with avoiding healthcare using multivariable logistic regression.ResultsAmong 452 TG women included in the study, 184 (40.7%) reported that they avoided seeking healthcare because of their transgender identity. In multivariable analysis, factors positively associated with avoiding seeking healthcare were: having been exposed to police violence (adjusted odd ratio [aOR]¿=¿2.20; 95% CI: 1.26 ¿ 3.83), internalized stigma (aOR¿=¿1.60, 95% CI: 1.02¿2.51), having experienced discrimination by healthcare workers (aOR¿=¿3.36: 95% CI: 1.25 ¿ 5.70) or patients (aOR¿=¿2.57; 95% CI: 1.58 ¿ 4.17), and currently living in the Buenos Aires metropolitan area (aOR¿=¿2.32; 95% CI: 1.44 ¿ 3.76). In contrast, TG women with extended health insurance were less likely to report avoiding healthcare (aOR¿=¿0.49; 95% CI: 0.26 ¿ 0.93).ConclusionsA high proportion of TG women in our sample reported avoiding healthcare. Avoiding healthcare was associated with stigma and discrimination in healthcare settings, as well as police violence experiences. Although further research is warranted, these finding suggests that socio-structural interventions tailored TG women needs are needed to improve access to healthcare among this population.","palabras_clave":"TRANSGENERO|ESTIGMA|HEALTHCARE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40163,"idioma_id":4,"titulo":"Towards Full Citizenship: Correlates of Engagement with the Gender Identity Law among Transwomen in Argentina","resumen":"Abstract  INTRODUCTION:  In May 2012, Argentina passed its 'Gender Identity' Law, which aimed to address the legal invisibility, discrimination and marginalization that transgender individuals have historically faced. The aim of this study was to explore factors associated with engagement with the Gender Identity Law among transwomen living in Argentina.  METHODS:  Data were derived from a 2013 nationwide, cross-sectional study involving transwomen in Argentina. Using multivariate logistic regression, we assessed the prevalence and factors associated with acquiring a gender-congruent identity card within the first 18 months of enactment of the Gender Identity Law.  RESULTS:  Among 452 transwomen, 260 (57.5%) reported that they had obtained a new gender-congruent identity card. In multivariate analysis, factors positively associated with acquiring a new ID were: previously experiencing discrimination by healthcare workers (adjusted odd ratio [aOR]&#8202;=&#8202;2.01, 95% CI: 1.27-3.20); having engaged in transition procedures (aOR&#8202;=&#8202;3.06, 95% CI: 1.58-5.93); and having a job other than sex work (aOR&#8202;=&#8202;1.81, 95% CI: 1.06-3.10). Foreign born transwomen were less likely to have obtained a new ID (aOR&#8202;=&#8202;0.14, 95% CI: 0.06-0.33).  CONCLUSIONS:  More than half of transwomen in our sample acquired a new gender-congruent ID within the first 18 months of enactment of the Gender Identity Law. However, access to and uptake of this right has been heterogeneous. In particular, our findings suggest that the most empowered transwomen may have been among the first to take advantage of this right. Although educational level, housing conditions, HIV status and sex work were not associated with the outcome, foreign-born status was a strong negative correlate of new ID acquisition. Therefore, additional efforts should be made in order to ensure that benefits of this founding policy reach all transwomen in Argentina.","palabras_clave":"GENDER IDENTITY|TRANSWOMEN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40164,"idioma_id":4,"titulo":"Early Skewed Distribution of Total and HIV-Specific CD8+ T-Cell Memory Phenotypes during Primary HIV Infection is Related to Reduced Antiviral Activity and Faster Disease Progression","resumen":"The important role of the CD8+ T-cells on HIV control is well established. However, correlates of immune protection remainelusive. Although the importance of CD8+ T-cell specificity and functionality in virus control has been underscored, furtherunraveling the link between CD8+ T-cell differentiation and viral control is needed. Here, an immunophenotypic analysis (interms of memory markers and Programmed cell death 1 (PD-1) expression) of the CD8+ T-cell subset found in primary HIVinfection (PHI) was performed. The aim was to seek for associations with functional properties of the CD8+ T-cell subsets,viral control and subsequent disease progression. Also, results were compared with samples from Chronics and EliteControllers. It was found that normal maturation of total and HIV-specific CD8+ T-cells into memory subsets is skewed in PHI,but not at the dramatic level observed in Chronics. Within the HIV-specific compartment, this alteration was evidenced byan accumulation of effector memory CD8+ T (TEM) cells over fully differentiated terminal effector CD8+ T (TTE) cells.Furthermore, higher proportions of total and HIV-specific CD8+ TEM cells and higher HIV-specific TEM\/(TEM+TTE) ratiocorrelated with markers of faster progression. Analysis of PD-1 expression on total and HIV-specific CD8+ T-cells from PHIsubjects revealed not only an association with disease progression but also with skewed memory CD8+ T-cell differentiation.Most notably, significant direct correlations were obtained between the functional capacity of CD8+ T-cells to inhibit viralreplication in vitro with higher proportions of fully-differentiated HIV-specific CD8+ TTE cells, both at baseline and at 12months post-infection. Thus, a relationship between preservation of CD8+ T-cell differentiation pathway and cellfunctionality was established. This report presents evidence concerning the link among CD8+ T-cell function, phenotype andvirus control, hence supporting the instauration of early interventions to prevent irreversible immune damage.","palabras_clave":"HIV|CD8|ACUTE HIV|PRIMARY HIV"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40165,"idioma_id":4,"titulo":"A Clinically Assisted Collaborative System Architecture for Preventing Falls in Elderly People","resumen":"Falls in older adults are not only frequent but also potentially disabling for them. Detecting and preventing these falls have an important impact in the life of the elderly people. This paper presents the architecture of a pervasive system designed to perform early detection of older adults in risk of falling or fell down. The system notifies the appropriate people or healthcare organizations in case of detecting a fall of the monitored person. This monitoring process produces minimum disruption in the life style of the elderly.","palabras_clave":"Falls Prevention and Detection|Pervasive Healthcare"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40166,"idioma_id":4,"titulo":"Impact of chemoreduction for conservative therapy for retinoblastoma in Argentina","resumen":"BACKGROUND:  Few studies were reported from developing countries regarding patient outcome and ocular survival in children with bilateral retinoblastoma treated with chemoreduction compared to external beam radiotherapy (EBRT).  PROCEDURE:  We undertook a retrospective study of three treatment eras: (1) (1988-1995) n = 68 when EBRT was used as primary conservative therapy; (2) (1995-2003) n = 46 when carboplatin-based systemic chemoreduction was introduced and (3) (2003-2009) (n = 83) when additional periocular chemotherapy was added for advanced tumors and pre-enucleation chemotherapy was given for those with massive buphthalmia.  RESULTS:  The probability of 5-year disease-free survival was 0.94 (95% confidence interval [CI] 0.91-0.98%) without significant differences among the three eras. Chemoreduction reduced the use of EBRT from 84.6% to 68.7% in eras 1 and 3, respectively (P = 0.008), which was more evident in cases with less advanced disease. Chemoreduction also significantly improved the 5-year probability of preservation of eyes with advanced disease from 0.13 (95% CI 0.04-0.27) during era 1 to 0.49 (95% CI 0.34-0.62) in era 3 (P < 0.0001). Chemoreduction was not associated with changes in the probability of extraocular relapse, which was reduced after the introduction of pre-enucleation chemotherapy. Second malignancies occurred in nine cases, acute myeloid leukemia being the most fatal one. Trilateral retinoblastoma occurred in three cases and all of them had been exposed to chemotherapy.  CONCLUSIONS:  Chemoreduction reduced the need for EBRT in eyes with less advanced disease and improved the preservation of eyes with advanced disease while its effects on secondary malignancies or trilateral disease remain unclear.","palabras_clave":"retinoblastoma|chemorreduccion|conservative|treatment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40167,"idioma_id":4,"titulo":"CLINICAL PHARMACOKINETICS OF INTRA-ARTERIAL MELPHALAN AND TOPOTECAN COMBINATION IN PATIENTS WITH RETINOBLASTOMA","resumen":"PURPOSE:  To assess the antitumor activity, toxicity, and plasma pharmacokinetics of the combination of melphalan and topotecan for superselective ophthalmic artery infusion (SSOAI) treatment of children with retinoblastoma.  DESIGN:  Single-center, prospective, clinical pharmacokinetic study.  PARTICIPANTS:  Twenty-six patients (27 eyes) with intraocular retinoblastoma.  METHODS:  Patients with an indication for SSOAI received melphalan (3-6 mg) and topotecan (0.5-1 mg; doses calculated by age and weight). Plasma samples were obtained for pharmacokinetic studies, and a population approach via nonlinear mixed effects modeling was used. Safety and efficacy were assessed and compared with historical cohorts of patients treated with melphalan single-agent SSOAI.  MAIN OUTCOME MEASURES:  Melphalan and topotecan pharmacokinetic parameters and efficacy and safety parameters.  RESULTS:  Twenty-seven eyes from 26 consecutive patients received 66 cycles of SSOAI melphalan and topotecan in combination. All 5 eyes treated as primary therapy responded to the combination chemotherapy and were preserved. Sixteen of the 22 eyes with relapsed or resistant tumors responded, but 3 of them ultimately underwent enucleation at a median of 8 months (range, 7.9-9.1 months). The incidence of grade III and IV neutropenia was 10.6% and 1.5%, respectively, which was comparable with historical controls of single-agent SSOAI melphalan. No episode of fever neutropenia was observed, and no patient required transfusion of blood products. The large variability in melphalan pharmacokinetics was explained by body weight (P&#8201;<0.05). Concomitant topotecan administration did not influence melphalan pharmacokinetic parameters. There was no effect of the sequence of melphalan and topotecan administration in plasma pharmacokinetics.  CONCLUSIONS:  A regimen combining melphalan and topotecan for SSOAI treatment of retinoblastoma is active and well tolerated. This combination chemotherapy previously showed synergistic pharmacologic activity, and we herein provide evidence of not increasing the hematologic toxicity compared with single-agent melphalan.","palabras_clave":"intra-arterial|pharmacokinetics|melphalan |topotecan"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40168,"idioma_id":4,"titulo":"A population-based study of retinoblastoma incidence and survival in Argentine children.","resumen":"BACKGROUND:An increased incidence of retinoblastoma in some developing countries has been reported but no conclusive data are available from population-based studies at national level.PURPOSE:To report the incidence and survival of retinoblastoma in Argentina from the National Pediatric Cancer Registry (ROHA) and the influence of socio-economical indicators on outcome.PROCEDURE:Cases reported to the ROHA (2000-2009) were analyzed. Incidence rates were calculated using National Vital Statistics and survival was estimated. The extended human development index (EHDI) was used as a socio-economical indicator.RESULTS:With 438 patients reported, an incidence of 5.0 cases per million children 0-14 years old (95% CI 3.5-6.4) was calculated. Median age at diagnosis was significantly higher for children from provinces with lower EHDI; (24 vs. 35 months for unilateral, (P = 0.003) and 9 versus 11.5 months for bilateral retinoblastoma (P = 0.027). The 3-year probability of survival was 0.87 and 0.94 for unilateral and bilateral retinoblastoma, respectively. Residents in provinces with higher EHDI had a better 3-year survival (0.93 vs. 0.77 for lower EHDI, P < 0.0001). Probability of survival was higher for patients treated at tertiary level institutions (P = 0.0015). The combination of low EHDI residence province with no treatment at a tertiary institution was associated with the worst survival outcome. For both, unilateral and bilateral disease, children who died were in average diagnosed at older age.CONCLUSIONS:The incidence of retinoblastoma in Argentina is comparable to that of developed countries. Retinoblastoma is diagnosed later and survival is lower in the less developed areas of the country.","palabras_clave":"retinoblastoma|incidence|survival|Argentina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40169,"idioma_id":4,"titulo":"A quantitative structure-property relationship analysis on vapor pressure of pesticides","resumen":"The Quantitative Structure-Property Relationships (QSPR) theory based on physicochemical descriptors and using multiple regression methods is suggested for modeling the vapor pressure values of 162 pesticides. Several feature selection methods including forward selection (FS), stepwise regression (SR), replacement method (RM), genetic algorithms (GA) are used to select the most relevant molecular descriptors from a pool of variables. The best subset of descriptors is used to build a QSPR model for the vapor pressures of pesticides. The variable subsets selected by the Replacement Method could improve the predictive ability and seems to be more reliable for the feature selection of these pesticides. In line with experimental studies, the obtained results offer excellent regression models and have a satisfactory predictive ability. The knowledge derived from this study would be of importance for predicting vapor pressure (VP) values for compounds with unknown literature values and may open new opportunities for the design and development of new pesticide compounds.       ","palabras_clave":"QUANTITATIVE STRUCTURE-PROPERTY RELATIONSHIPS|MULTIVARIABLE LINEAR REGRESSION (MLR)|PESTICIDES|VAPOR PRESSURE (VP)|PARTIAL SWARM OPTIMIZATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40170,"idioma_id":4,"titulo":"ANTERIOR SEGMENT INVASION IN RETINOBLASTOMA. IS IT A RISK FACTOR FOR EXTRAOCULAR RELAPSE?","resumen":"AbstractWe report a retrospective review of patients with retinoblastoma and anterior segment invasion (ASI) as risk factors for extraocular relapse. Only those with ASI combined with postlaminar optic nerve invasion and\/or scleral invasion received adjuvant chemotherapy and those with tumor at the resection margin received orbital radiotherapy. Those with only uveal invasion did not receive adjuvant therapy. Of 479 evaluable patients, 67 patients had pathologically confirmed ASI, including 52 with anterior chamber invasion and 47 with iris or ciliary body invasion. ASI occurred with other pathology risk factors (25 had concomitant posterior uveal invasion, 36 had postlaminar optic nerve invasion, 11 with cut-end invasion, and 25 with scleral invasion). The 5-year disease-free survival (pDFS) was 0.9 (95% CI, 0.8-0.95) for children with ASI with no significant differences among children with other pathology risk factors with and without ASI. ASI was not significantly associated with extraocular relapse in multivariate analysis. There were no significant differences in pDFS for patients with anterior chamber invasion and those with iris-ciliary body invasion (pDFS 0.89 [95% CI, 0.65-0.96] vs. 0.93 [95% CI, 0.61-0.98]). To conclude, ASI was seen with other pathology risk factors and it did not add a significant risk for extraocular relapse.","palabras_clave":"retinoblastoma  |anterior| segment |invasion"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40171,"idioma_id":5,"titulo":"EVALUACIÓN TECNOLÓGICA DE MICROORGANISMOS RELEVANTES PARA LA INDUSTRIA ALIMENTARIA","resumen":"Las bacterias lácticas son microorganismos ampliamente utilizados en la industria para la  producción y conservación de alimentos debido a su particular metabolismo que confiere al producto interesantes características desde el punto de vista tecnológico: organolépticas (aroma, sabor, textura), nutricionales (síntesis de nutrientes o remoción de compuestos antinutricionales) y de calidad y seguridad del alimento (producción de compuestos antimicrobianos y status GRAS).  En este contexto, el objetivo de este trabajo fue aislar cepas de bacterias lácticas a partir de productos fermentados artesanales que se comercializan localmente y evaluar diferentes propiedades tecnológicas a los fines de seleccionar cepas con potencial aplicación en el desarrollo de fermentos que permitan obtener productos de calidad reproducible; nutricional y sensorialmente superiores. A tal fin, muestras de productos lácteos (quesos frescos y madurados), cárnicos (salamines, chorizos criollos, salchichas, queso de chancho) y conservas vegetales (aceitunas, pickles) fueron sembradas en medios de cultivo selectivos para el crecimiento de bacterias lácticas y lactobacilos (MRS y Agar Rogosa respectivamente) e incubadas durante 72 h en condiciones de microaerofilia. Los microorganismos aislados, con características de bacterias lácticas, fueron evaluados en cuanto a su capacidad acidificante (pH y tasa de acidificación en leche), osmotolerancia (crecimiento en presencia de 2; 4; 7 y 10% NaCl), producción de compuestos de aroma (diacetilo-acetoína en leche), actividad proteolítica (liberación de aminoácidos a partir de la caseina), y actividad lipolitica  (hidrólisis de triglicéridos en medio agarizado). De 75 muestras procesadas, se obtuvieron 143 aislamientos, de los cuales se seleccionaron 118 que responden a la características de bacilos Gram (+), catalasa (-), nitrato (-), ac. láctico (+). En cuanto a sus propiedades tecnológicas, se observó una amplia variabilidad entre las cepas pudiendo inferirse algunas relaciones entre propiedad y  procedencia, como mayor tolerancia a la sal en aquellos provenientes de encurtidos, alta capacidad acidificante en los provenientes de lácteos y elevada proteolísis en los derivados de productos cárnicos. Los resultados obtenidos representan el paso inicial en el estudio y la selección de microorganismos con potencial transferencia a la industria para su aplicación a la producción de diversos alimentos de acuerdo a las propiedades tecnológicas que cada producto requiera.","palabras_clave":"BACTERIAS LACTICAS|FERMENTACION|PROPIEDADES TECNOLOGICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40172,"idioma_id":4,"titulo":"Fusarium poae and mycotoxins: potential risk for consumers","resumen":"Fusarium head blight is an important disease affecting cereal grains. Fusarium graminearum is the major causal agent of this disease around the world, but some researchers have documented the increased importance of F. poae. Moreover, F. poae presence may be accompanied of its mycotoxins production, being able to produce trichothecenes of type A diacetoxyscirpenol, monoacetoxyscirpenol, scirpentriol, HT-2 toxin, T-2 toxin and neosolaniol, as well as the type B nivalenol and fusarenone-X. Outside the trichotecenes group, F. poae has been reported to produce enniatins, beauvericin and moniliformin. Due to F. poae may be present in cereal grains used for food and processed products, the aims of this review is to recognize the importance of the hazard effects of the F. poae mycotoxins on animal and human consumers by a short description of the methods that allow determining the mycotoxin presence and analyse the different effects caused by the mycotoxin exposure.","palabras_clave":"FUSARIUM POAE|METHODS|MYCOTOXINS|EFFECTS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40173,"idioma_id":4,"titulo":"Characterization of a Fusarium poae world-wide collection by using molecular markers","resumen":"Fusarium poae has been considered as a minor species among those that cause Fusarium Head Blight (FHB) disease but in recent years several researchers have documented a high frequency of occurrence of this species. In this study, a total of 173 F. poae isolates from Argentina, Belgium, Canada, England, Finland, France, Germany, Hungary, Italy, Luxembourg, Poland, Switzerland and Uruguay were evaluated by using inter simple sequence repeats (ISSR) and amplified fragment length polymorphism (AFLP) to evaluate genetic variability within F. poae and to amplify MAT idiomorphs as a possible mechanism that could explain part of the variability found in this species. The molecular analysis obtained from both molecular markers showed a high intraspecific variability. However, a partial clustering between F. poae isolates and their geographic origin was obtained by ISSR markers while AFLP showed isolates from different geographic locations distributed throughout the dendrogram. Moreover, ISSR grouped all the F. poae isolates into a different cluster from the F. langsethiae and F. sporotrichioides isolates used as outgroups compared with the dendrogram obtained using AFLP markers. Analysis of molecular variance (AMOVA) indicated a high genetic variability in the F. poae collection, with most of the genetic variability resulting from differences within, rather than between American and European populations by using both molecular markers. Regarding MAT idiomorphs, for most F. poae isolates both MAT-1 and MAT-2 were present from each isolate.","palabras_clave":"AFLP|FUSARIUM POAE|GENETIC VARIABILITY|ISSR|MAT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40174,"idioma_id":4,"titulo":"Atomistic simulation of the mechanical properties of nanoporous gold","resumen":"We study the mechanical behavior of nanoporous gold under uniaxial compression and strain rates in the range of 107?109&nbsp;s&#8722;1 using molecular dynamics simulations. We consider the low-porosity regime (porosity of &#8764;5%), which is characterized by several stages of plastic deformation. At the onset of plasticity, pores act as if isolated by emitting ?shear? dislocation loops. At higher deformations, the mechanical response is determined by the interactions between dislocations in the dense dislocation forest, leading to strain hardening. Increasing the strain rate results in an increasing flow stress ranging from 0.4 to 0.7&nbsp;GPa within the range of applied strain rates. The von Mises stress &#963;VM&#963;VM in the hardening regime features two possible power-law dependencies as a function of dislocation density &#961;d&#961;d: in the initial stages of plastic deformation we obtained &amp;lt;img height='18' border='0' style='vertical-align:bottom' width='66' alt='View the MathML source' title='View the MathML source' src='http:\/\/origin-ars.els-cdn.com\/content\/image\/1-s2.0-S1359645414005692-si23.gif'&amp;gt;&#963;VM&#8733;&#961;d2, but changes to Taylor hardening &amp;lt;img height='20' border='0' style='vertical-align:bottom' width='75' alt='View the MathML source' title='View the MathML source' src='http:\/\/origin-ars.els-cdn.com\/content\/image\/1-s2.0-S1359645414005692-si24.gif'&amp;gt;&#963;VM&#8733;&#961;d1\/2 at higher dislocation densities. The velocity of dislocations is estimated to be &#8764;60% of the speed of sound in the early stages of plastic deformation, but later decreases dramatically due to dislocation?dislocation and dislocation?pore interactions. The unloading of the complex dislocation and stacking fault network leads to the production of vacancies. As a result, we propose that the vacancy clusters observed experimentally in recovered samples and attributed to ?dislocation-free? plasticity are instead due to the aggregation of those vacancies left behind during recovery.","palabras_clave":"Molecular dynamics (MD)|Plastic deformation| Nanoporous|Nanovoid collapse"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40175,"idioma_id":5,"titulo":"RECONSTRUCCIÓN PALEOAMBIENTAL DE LA PLANICIE COSTERA DE MAR CHIQUITA (PROVINCIA DE BUENOS AIRES, ARGENTINA) DURANTE EL HOLOCENO, BASADA EN DIATOMEAS","resumen":"Se analizaron los ensambles de diatomeas de un testigo extraído en la zona  26'  norte de la planicie costera de Mar Chiquita (37º 23? 39? S, 57 º9? 33? O) a fin de reconocer variaciones de salinidad y profundidad. Los sedimentos de la base fueron datados en 5802±70  14 C años AP. Se definieron cuatro unidades litológicas: limos gris?verdosos, limos arenosos castaño?grisáceos, facies heterolíticas y limos arenosos castaños. Se identificaron doscientas especies de diatomeas que fueron agrupadas según sus tolerancias salinas y formas de vida. El análisis de agrupamiento definió dos zonas diatomológicas. La sección inferior (Zona I), desde los 5802±70 a los 4176±30  14 C años AP, estuvo dominada por Paralia sulcata (Ehrenberg) Cleve y Psammococconeis cf. disculoides (Hustedt) García, acompañadas por plancton, epipsammon y epífitas marino?salobres, indicando condiciones marino?costeras. A partir de los 4176±30  14 C    años AP (Zona II), la salinidad y la profundidad decrecen hacia el tope: P. sulcata disminuye, aparecen Planothidium delicatulum (Kützing) Roundy Bukht (salobre) e Hippodonta hungarica Grunow (salobre?dulceacuícola) y aumentan las diatomeas bentónicas y epífitas. La comparación de los ensambles fósiles y actuales mediante un análisis de ordenamiento multidimensional (MDS) mostró analogía de los fósiles con los actuales de la desembocadura. La sucesión sedimentológica estudiada (Ruta 11), representa la colmatación de un ambiente costero?marino que evolucionó hacia una laguna costera y posteriormente hacia una marisma salobre?dulceacuícola durante la fase regresiva. Los nuevos datos diatomológicos y sedimentológicos sustentan el modelo regional de fluctuaciones holocenas del nivel del mar.","palabras_clave":"Diatomeas|Holoceno|Albufera|Provincia de Buenos Aires"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40176,"idioma_id":5,"titulo":"Planillas para calcular el ahorro de energía en refrigeración y la etiqueta de eficiencia  energética de calefacción en edificios del Nordeste Argentino","resumen":"Trabajo seleccionado para publicar como articulo, de la XXXVII Reunión de Trabajo de la Asociación Argentina de Energías Renovables y Ambiente, ASADES, y del XXIII Encuentro de la Asociación Internacional para la Educación en Energía Solar Jornadas de Socialización de Buenas Prácticas Energético Ambientales, Facultad de Ingeniería, Universidad Nacional de Misiones, Oberá, Misiones, Argentina, Octubre de 2014. El contenido refleja resultados de los tareas de investigación ejecutadas en la cátedra Estructuras II, en el proyecto de investigación aplicada acreditado por la SGCyT UNNE sobre la evaluación energética aplicada por medio de auditorias energéticas simples y constrastación de resultados obtenidos con herramientas informáticas adecuadas para el desarrollo de tecnologías de la construcción para el NEA.","palabras_clave":"ENERGÍA|TECNOLOGÍA|ARQUITECTURA|MEDIOAMBIENTE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40177,"idioma_id":5,"titulo":"La termografía como auxiliar en la evaluación higrotérmica de edificios: el caso del edificio de la Facultad de Arquitectura de la UNNE","resumen":"Se comentan los resultados de la aplicación  cualitativa de la termografía como  complemento de una evaluación de  desempeño higrotérmico energético  realizada en el edificio de la Facultad  de Arquitectura y Urbanismo de  la Universidad Nacional del Nordeste, Campus UNNE de Resistencia, Chaco. Dicha  evaluación consistió en mediciones de temperatura y humedad, contrastadas  con simulaciones mediante software  específi co, en una muestra de aulas  del edificio mencionado, durante períodos de verano y de invierno. En este  contexto, se exponen las aplicaciones  de la termografía como auxiliar en el  proceso de la evaluación mencionada,  especialmente en detección de puntos  críticos: puentes térmicos, incidencia del asoleamiento  y de los colores superfi ciales de las  distintas superficies de la envolvente constructiva, entre otros.","palabras_clave":"ENERGÍA|TECNOLOGÍA|ARQUITECTURA|AUDITORÍAS ENERGÉTICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40178,"idioma_id":5,"titulo":"Abordaje de los sistemas de construcción en seco de tipo 'entramado' (steel y balloon frame) y la sustentabilidad edilicia en la asignatura Construcciones II - FAU - UNNE: ciclos 2012 y 2013","resumen":"Se presenta una experiencia de innovación pedagógica implementada en la cátedra Arquitectura II?UP B, referida a la introducción del Diseño Ambientalmente Consciente en la resolución de problemas de diseño en el Taller de Arquitectura. Se analizan los resultados obtenidos y sus implicancias, en diferentes dimensiones de interés en la práctica docente universitaria, contrastadas con encuestas realizadas a los alumnos de la asignatura. La sistematización y valoración de las actividades desarrolladas permite califi car la experiencia como muy satisfactoria, no solo desde el punto de vista disciplinar, sino también por propiciar una actitud crítica y refl exiva frente al desafío de la Arquitectura Sustentable.","palabras_clave":"ENERGÍA|TECNOLOGÍA|ARQUITECTURA|PRE FABRICACIÓN E INDUSTRIALIZACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40179,"idioma_id":5,"titulo":"La morfología dental en contextos clínicos, antropológicos y forenses","resumen":"El propósito de este artículo es hacer una revisión de la literatura sobre los rasgos morfológicos dentales dentro de los contextos odontológico, antropológico y forense. Son empleados en la estimación de las relaciones biológicasentre poblaciones y relevantes en los problemas legales. Su naturaleza puede predisponer al desarrollo de procesos patológicos, de ahí la importancia de su conocimiento para el odontólogo general.","palabras_clave":"DENTICION|ANATOMIA|ODONTOLOGIA GENERAL |ANTROPOLOGIA FISICA|ODONTOLOGIA FORENSE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40180,"idioma_id":5,"titulo":"Herramienta para evaluar atributos de mantenibilidad en aplicaciones PHP","resumen":"La medición de software permite expresar de manera cuantitativa atributos como el grado de mantenibilidad de una aplicación a partir del análisis de un conjunto de métricas específicas. En este trabajo se presenta una herramienta de medición de atributos vinculados con la mantenibilidad en aplicaciones orientadas a objetos, en particular, al código escrito en PHP. Esta herramienta automatiza un método de medición basado en GQM, calcula los valores de un conjunto de métricas, almacena los resultados de las distintas mediciones y permite comparar cómo se comportan los atributos evaluados. Para la validación del método y la herramienta se evaluó el sistema de gestión de contenidos Joomla  en cinco versiones. Esto permitió observar el comportamiento de los indicadores que surgen de las métricas OO que se vinculan a determinados atributos de calidad en un producto software específico que se encuentra en estado de explotación y susceptible de mantenimiento evolutivo.","palabras_clave":"CALIDAD DEL SOFTWARE|CALIDAD DEL PRODUCTO|MANTENIBILIDAD|GESTION CUANTITATIVA DE PROYECTOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40181,"idioma_id":5,"titulo":"Vejez y salud mental: el camino de los jueces hacia la nueva capacidad","resumen":"En nuestro tiempo, la ancianidad se nos presenta como una etapa perfectamente esperable, acorde con la profundización del fenómeno del envejecimiento poblacional que hoy, además de ser global, es multigeneracional. La vejez supone una serie de modificaciones a nivel físico, psíquico y ocupacional de la persona, que se traducen en un cambio en la autovaloración, en la relación con la sociedad y, principalmente, en su inserción familiar, de consecuencias no siempre positivas para su salud mental. Se abordará la vulnerabilidad física y mental de las personas mayores, que pueden derivar en situaciones de dependencia o discapacidad, mal interpretadas como causal es de insania o inhabilitación.","palabras_clave":"Capacidad|Vejez|Salud mental"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40182,"idioma_id":4,"titulo":"Evaluation of the immune response to Anaplasma marginale MSP5 protein using a HSV-1 amplicon vector system or recombinant protein","resumen":"Anaplasma marginale is an intraerythrocytic vector-borne infectious agent of cattle. Immunization with the current vaccine, based on parasitized erythrocytes with live Anaplasmacentrale, shows some constraints and confers partial protection, suggesting the feasibility for the development of new generation of vaccines. The aim of the present study was to assess the effect of sequential immunization of BALB\/c mice, with herpesvirusamplicon vector-based vaccines combined with protein-based vaccines, on the quality of the immune response against the major surface protein 5 of A. marginale. The highest antibody titers against MSP5 were elicited in mice that received two doses of adjuvanted recombinant protein (p<0.0001). Mice treated with a heterologous prime-boost strategy generated sustained antibody titers at least up to 200 days, and a higher specific cellular response. The results presented here showed that sequential immunization with HSV-based vectors and purified antigen enhances the quality of the immune response against A. marginale.","palabras_clave":"Anaplasma marginale|herpesvirus amplicon vectors|recombinant MSP5|vaccines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40183,"idioma_id":5,"titulo":"Caracterizacion citogenetica de Pachyurus bonariensis Steindachner (1879) (Perciformes, Sciaenidae) del Rio Alto Parana","resumen":"En el presente trabajo se llevo a cabo la primer caracterizacion citogenetica de la corvina Pachyurus bonariensis (Perciformes, Sciaenidae) capturada en tres puntos de muestreo sobre el Rio Parana. Las preparaciones cromosomicas se obtuvieron mediante suspension celular, utilizando tejidos renales y fueron analizadas mediante tecnicas de coloracion convencional y diferenciales (Bandeos C y NOR). Se analizaron 19 ejemplares de ambos sexos a partir de los cuales se pudo determinar un numero cromosomico diploide de 48 cromosomas acrocentricos, sin evidencias de sistemas de determinacion cromosomica del sexo. La tecnica de coloracion argentica mostro regiones organizadoras nucleolares en un solo par de cromosomas y el bandeo C bloques heterocromaticos pericentromericos en varios cromosomas del complemento.","palabras_clave":"PECES CITOGENETICA|SCIAENIDAE|PACHYURUS|RIO PARANA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40184,"idioma_id":4,"titulo":"Experimental in vitro infection of rat osteoblasts with measles virus stimulates osteogenic differentiation","resumen":"In this work we characterized the infection of a primary culture of rat osteoblastic lineage  27 cells (OBCs) with measles virus (MeV) and the effect of infection on cell differentiation and  28 maturation. Infection of OBCs with MeV led to high titers of infectivity released early after  29 infection. Also, analysis of mRNAs corresponding to osteogenic differentiation markers like  30 alkaline phosphatase (ALP), bone sialo-protein (BSP) and bone morphogenetic proteins  31 (BMPs) 1-4-5-7 in OBCs revealed higher values (2 to 75-fold of increment) for infected  32 cells in comparison with uninfected controls. Differentiation of OBCs in osteogenic medium  33 prior to infection influenced the level of stimulation induced by MeV. Furthermore,  34 treatment of OBCs with Ly294002, a PI3K\/AKT inhibitor, increased viral titers, whereas  35 treatment with 10 &#956;M or 100 &#956;M ATP&#61543;S diminished MeV multiplication. In addition,  36 increments of osteogenic differentiation markers induced by MeV infection were not  37 modified either by treatment with Ly294002 or ATP&#61543;S. These data provide the first  38 evidence demonstrating that MeV can infect osteoblasts in vitro leading to osteoblastic  39 differentiation, a key feature in bone pathogenic processes like otosclerosis.","palabras_clave":"MEASLES VIRUS|OSTEOBLASTS|DIFFERENTIATION|OTOSCLEROSIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40185,"idioma_id":4,"titulo":"Bio-efficacy of the essential oil of Oregano (Origanum vulgare Lamiaceae. ssp. hirtum)","resumen":"The aim of this study was to investigate the bioactivity of the essential oil isolated from Origanum vulgare L. (EOv). We analyzed the in vivo anti-inflammatory properties in a mouse-airway inflammation model and the in vitro antimicrobial activity, genotoxicity over the anaphase-telophase with the Allium cepa strain and its cytotoxicity\/viability in A549 culture cells. In vivo, EOv modified the levels of tumor necrosis factor -&#945; and viable activated macrophages and was capable to mitigate the effects of degradation of conjugated dienes. In vitro, EOv reduced the viability of cultured A549 cells as well as the mitotic index and a number of chromosomal aberrations; however, it did not change the number of phases. We found that EOv presents antimicrobial activity against different Gram (-) and (+) strains, measured by disc-diffusion test and confirmed with a more accurate method, the AutoCad software. We postulate that EOv presents antibacterial, antioxidant and chemopreventive properties and could be play an important role as bioprotector agent","palabras_clave":"ANTIBACTERIAL|CANCER|CHEMOPREVENTIVE|LUNG INFLAMMATION|ORIGANUM VULGARE|TERPENES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40186,"idioma_id":4,"titulo":"Low distortion switching amplifier with discrete-time click modulation","resumen":"An all-digital Class-D amplifier based on a discretetime implementation of the click modulator is presented. The algorithm is able to generate binary signals with separated baseband, displacing the harmonic content produced by the modulation process above certain frequency chosen by the designer. Perfect demodulation can be achieved by a simple lowpass filter. Previous implementations of the discrete-time click modulator reported in the literature suffer from aliasing in the frequency domain. The approach proposed here avoids aliasing, without the necessity to increase (interpolate) the sampling frequency of the signals.  Following a brief theoretical introduction, the performance of the proposed architecture is demonstrated by experimental measurements performed on an H-bridge amplifier. An 88 dB SNR and a THD+N less than 0.04 % is attainable over the entire audio band, extending from 20 Hz up to 20 kHz; on the other hand, no traces of IMD appear above the predicted noise floor.  These performance indices are obtained for switching rates as low as 40 kHz. The reduction of the switching frequency provides more flexibility for the design of the demodulation stage allowing to trade off between the complexity of the demodulation filter and the achievable efficiency of the switching stage.","palabras_clave":"DIGITAL MODULATION|PULSE WIDTH MODULATION|SWITCHING AMPLIFIERS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40187,"idioma_id":5,"titulo":"Modelo blended learning en la enseñanza  universitaria: el aula virtual de  probabilidad y estadística","resumen":"Se presentan los resultados de experiencias de integración de TIC en el área de ciencias básicas de carreras de ingeniería","palabras_clave":"BLENDED LEARNING|PROBABILIDAD Y ESTADÍSTICA|AULA VIRTUAL|ENSEÑANZA DE LA INGENIERIA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40188,"idioma_id":5,"titulo":"El uso de software de diseño aplicado a la  enseñanza de la ingeniería mecánica","resumen":"Se presenta una experiencia de innovación educativa en ingeniería mecánica usando software de simulación","palabras_clave":"INGENIERIA|MECANICA|SIMULACION|SOFTWARE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40189,"idioma_id":5,"titulo":"Identificación de variables para un modelo  alternativo de educación en la enseñanza  de la ingeniería","resumen":"Se exploran e identifican variables para desarrollar un modelo alternativo de enseñanza de la ingenieria con integración de TIC","palabras_clave":"ENSEÑANZA DE LA INGENIERIA|TECNOLOGIAS DE LA INFORMACION Y COMUNICACION|BLENDED LEARNING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40190,"idioma_id":5,"titulo":"Implementación de Auditorías Energéticas en Establecimientos Educativos de la ciudad de Resistencia, Chaco. Acuerdo de Trabajo FAU UNNE - MECCyT","resumen":"En el marco de un acuerdo de trabajo suscripto entre la FAU, UNNE y el Ministerio de Educación de la Provincia del Chaco, se realizaron 63 monitoreos del comportamiento higrotérmico y lumínico de ocho edifi cios escolares de la  ciudad de Resistencia, durante un año, mediante instrumental de última generación aportado por el ministerio, incluyendo entrevistas, encuestas y charlas informativas a docentes y alumnos. Como resultado se verifi có que dichos edifi cios carecen de condiciones de bienestar adecuadas, en todas las estaciones del año. Las mediciones realizadas permitirán validar modelos teóricos obtenidos mediante programas informáticos de simulación dinámica, para la elaboración de propuestas de optimización.","palabras_clave":"ENERGÍA|AUDITORÍA ENERGÉTICA|TECNOLOGÍA DE LA CONSTRUCCIÓN|MEDIOAMBIENTE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40191,"idioma_id":4,"titulo":"Self-Trapping of Excitons, Violation of Condon Approximation, and Efficient Fluorescence in Conjugated Cycloparaphenylenes","resumen":"Cycloparaphenylenes, the simplest structural unit of armchair carbon nanotubes, have unique optoelectronic properties counterintuitive in the class of conjugated organic materials. Our time-dependent density functional theory study  and excited state dynamics simulations of cycloparaphenylene chromophores provide a simple and conceptually appealing physical picture explaining experimentally observed trends in optical properties in this family of molecules. Fully delocalized degenerate second and third excitonic states define linear absorption spectra. Self-trapping of the lowest excitonic state due to electron&#8722;phonon coupling leads to the formation of spatially localized excitation in large cycloparaphenylenes within 100 fs. This invalidates the commonly used Condon approximation and breaks optical selection rules, making these materials superior fluorophores. This process does not occur in the small molecules, which remain inefficient emitters. A complex interplay of symmetry, &#960;-conjugation, conformational distortion and bending strain controls all photophysics of cycloparaphenylenes.","palabras_clave":"Time-dependent density functional theory|nonadiabatic excited state molecular dynamics|exciton-vibrational coupling|photoluminescence spectra"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40192,"idioma_id":5,"titulo":"DEL FUNCIONALISMO AL CONSUMO MULTITASKING. LÍMITES Y POTENCIALIDADES DE LOS ESTUDIOS DE RECEPCIÓN","resumen":"El objetivo de este artículo es diagramar una matriz conceptual sobre los procesos de consumo mediático, un subcampo de investigación que despierta grandes debates en la actualidad. Para ello, en primer lugar reconstruimos la conformación del campo teórico-metodológico en que esta temática se inscribe, y proponemos repensar algunos de los paradigmas en los que se desarrollan específicamente los estudios de recepción de audiencias en América Latina. En segundo lugar, cuestionamos la noción de recepción, y proponemos el debate sobre las posibilidades y los límites de los estudios empíricos. Finalmente, las diferentes perspectivas pondrán en evidencia los problemas metodológicos que persisten en el área, por lo que reflexionaremos sobre cómo abordar futuras investigaciones.","palabras_clave":"RECEPCIÓN|CONSUMO|MEDIOS DE COMUNICACION|AUDIENCIAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40193,"idioma_id":5,"titulo":"Síntesis de Nanocatalizadores para Celdas de Combustible de Metanol Directo","resumen":"Las celdas de combustible de metanol directo, DMFCs, permiten una conversión completa de la energía de la reacción química en energía eléctrica. El platino es el catalizador más utilizado en las DMFCs. Para poder generar cantidades aceptables de corriente no se puede prescindir del uso de este metal como catalizador. Como la catálisis se manifiesta a nivel superficial, si se sintetizan nanopartículas catalíticas soportadas sobre negro de carbón se obtendrá una gran área de reacción. El empleo de la nanotecnología y la combinación de Pt con otros metales aumenta la actividad electrocatalítica y reduce el costo de las celdas de   combustible. Se sintetizan y se determinan las actividades electrocatalíticas de nanopartículas en base platino, como material de electrodo para el cátodo donde se lleva a cabo la reacción de reducción de oxígeno en la DMFC.","palabras_clave":"nanopartículas|energías alternativas|ORR|DMFC|celdas de combustibles"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40194,"idioma_id":5,"titulo":"Diálogos civilizados en el barro de las memorias. Otra discusión sobre los modos de pensar(nos) intelectuales desde Facundo.","resumen":"A mediados del siglo XIX, Domingo Faustino Sarmiento escribe Facundo. Civilización y Barbarie en las Pampas argentinas. Desde aquellos días hasta la actualidad han ocurrido (y se han construido) varios hechos, historias y memorias. En esta oportunidad, nos atrevemos a dialogar nuevamente con Facundo y con Domingo para entablar viejas y nuevas discusiones sobre el rol de los intelectuales en relación con las construcciones de la memoria. A modo de introducción, ofrecemos algunasadvertencias para la lectura de nuestro texto. En segundo lugar, nos adentramos en la puesta en discusión de la obra en relación con los mecanismos de memoria\/olvido. Luego, pretendemos comenzar a travesar algunos sedimentos de Facundo hechos cuerpo en dos casos. Y finalmente tomamos posición para reflexionar sobre el rol del intelectual a partir de la relectura propuesta del texto sarmientino.","palabras_clave":"Diálogo|Memoria |Intelectuales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40195,"idioma_id":5,"titulo":"MODELO FISICO Y SIMULACIÓN COMPUTACIONAL BAJO SIMUSOL DE UN COLECTOR SOLAR DE AIRE CON ABSORBEDOR DE MALLAS METÁLICAS1","resumen":"Se presentan en este trabajo el modelo físico y la simulación computacional de un colector solar de aire con  absorbedor poroso formado por capas de mallas metálicas de material desplegado liviano. El modelo físico es análogo al de  un colector de paso simple de flujo, considerando el incremento del área efectiva de intercambio absorbedor - flujo por  porosidad. El absorbedor es modelado como un intercambiador compacto, considerando la influencia del número de Stanton  en la convección interna y el aporte de calor al absorbedor por conducción y por incidencia de radiación solar, ademas de  considerar el área efectiva para el intercambio radiativo entre el absorbedor poroso y la cubierta. Se validó el modelo de  colector mediante datos medidos en un prototipo. Se realizó una simulación bajo Simusol con entrada variable de datos  ambientales y temperatura de flujo, controlando los resultados mediante la diferencia entre valores simulados y medidos. Los  resultados obtenidos son satisfactorios, con un buen ajuste entre valores medidos y simulados, permitiendo recrear la curva  de eficiencia del colector con buena precisión.","palabras_clave":"Colector solar de aire|absorbedor poroso|eficiencia térmica|modelo físico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40196,"idioma_id":4,"titulo":"A Conformational Model for MTPA Esters of Chiral N-(2-Hydroxyalkyl)acrylamides","resumen":"The absolute stereochemistry of novel chiral N-(2-hydroxylalkyl)acrylamides prepared by a lipase-catalyzed resolution was successfully determined by 1 H NMR of their MTPA esters. The method was validated for this particular case by computational experiments.","palabras_clave":"Acrylamide|MTPA ester|molecular modeling"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40197,"idioma_id":5,"titulo":"Rugosidad en pavimentos de hormigon, influencia de la temperatura","resumen":"Las losas de los pavimentos de hormigón poseen variaciones en su forma diariamente, el parámetro que condiciona la misma es la variación de temperatura entre el día y la noche, lo que origina diferencias térmicas entre las fibras superior e inferior de la losa. Lo propio ocurre con las variaciones de humedad. Según sea la diferencia térmica las losas poseen diferentes curvaturas, cóncavas cuando la fibra inferior (en contacto con la subbase) tiene mayor temperatura y convexas cuando la fibra superior está más caliente (recibe los rayos solares en forma directa), ocurriendo una situación similar con la variación del contenido de humedad en el espesor de la losa.Esta variación de forma origina que los resultados de mediciones de rugosidad realizados en distintos momentos del año tengan variaciones. Mediciones periódicas hechas en tramos de control con pavimento de hormigón indicaron diferencias mayores a las que se observan en pavimentos asfálticos.En este trabajo se analizaron los alabeos térmicos en forma teórica y se cuantificó la influencia de los mismos en los resultados de rugosidad, lo cual fue corroborado en mediciones in situ en tramos de control.Finalmente, se indican algunas recomendaciones para minimizar la influencia de los alabeos térmicos en los resultados de rugosidad.","palabras_clave":"pavimentos de hormigón|rugosidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40198,"idioma_id":5,"titulo":"El derecho a la vida en una sentencia del Tribunal Constitucional Plurinacional de Bolivia","resumen":"Análisis de la sentencia del Tribunal Constitucional Plurinacional de Bolivia sobre aborto.","palabras_clave":"Aborto|Derechos humanos"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40199,"idioma_id":4,"titulo":"Esophageal atresia and prenatal exposure to mycophenolate","resumen":"Mycophenolate mofetil is a widely prescribed immunosuppressive agent for transplant patients and autoimmune diseases. Potential teratogenic effects after in utero exposure to mycophenolate mofetil has been described in human clinical observations. The complete clinical pattern is still being delineated. We present four newborns with esophageal atresia and other congenital anomalies, prenatally exposed to mycophenolate mofetil during the first trimester. Two of the cases had other defects related to the embryopathy: microtia, eye abnormalities and oral clefts. Two cases did not show major craniofacial anomalies. We propose that esophageal atresia with or without tracheoesophageal fistula is a feature of mycophenolate embryopathy even without the presence of other major craniofacial anomalies. The human teratogenicity of MMF is reinforced by this report, and the current contraceptive recommendations about its use in fertile women are stressed.","palabras_clave":"atresia de esofago|micofenolato|teratología"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40200,"idioma_id":5,"titulo":"El Poder Legislativo nacional y la responsabilidad social. Análisis de su conceptualización en los proyectos de ley presentados en el Senado de la Nación","resumen":"Las organizaciones de todo el mundo, y  sus partes interesadas, perciben la necesidad y los beneficios de un comportamiento  socialmente responsable, como reflejo el creciente reconocimiento de la  importancia de garantizar ecosistemas sanos, equidad social y buena gobernanza.  La responsabilidad social alude a un  modelo estratégico de gestión, que contempla los impactos económicos, sociales  y ambientales asociados al desarrollo de las actividades de las organizaciones.Tomando como criterio de análisis el  marco internacionalmente consensuado de responsabilidad social, se abordan dos  proyectos de ley a efectos de analizar el tratamiento del tema en el marco de la labor legislativa del Senado  de la Nación Argentina.","palabras_clave":"RESPONSABILIDAD SOCIAL|PROYECTO DE LEY|POLITICA|LEGISLACION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40201,"idioma_id":4,"titulo":"Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data","resumen":"BACKGROUND:  Neuraminidase inhibitors were widely used during the 2009-10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A H1N1pdm09 virus infection.  METHODS:  We assembled data for patients (all ages) admitted to hospital worldwide with laboratory confirmed or clinically diagnosed pandemic influenza A H1N1pdm09 virus infection. We identified potential data contributors from an earlier systematic review of reported studies addressing the same research question. In our systematic review, eligible studies were done between March 1, 2009 (Mexico), or April 1, 2009 (rest of the world), until the WHO declaration of the end of the pandemic (Aug 10, 2010); however, we continued to receive data up to March 14, 2011, from ongoing studies. We did a meta-analysis of individual participant data to assess the association between neuraminidase inhibitor treatment and mortality (primary outcome), adjusting for both treatment propensity and potential confounders, using generalised linear mixed modelling. We assessed the association with time to treatment using time-dependent Cox regression shared frailty modelling.  FINDINGS:  We included data for 29,234 patients from 78 studies of patients admitted to hospital between Jan 2, 2009, and March 14, 2011. Compared with no treatment, neuraminidase inhibitor treatment (irrespective of timing) was associated with a reduction in mortality risk (adjusted odds ratio [OR] 0·81; 95% CI 0·70-0·93; p=0·0024). Compared with later treatment, early treatment (within 2 days of symptom onset) was associated with a reduction in mortality risk (adjusted OR 0·48; 95% CI 0·41-0·56; p<0·0001). Early treatment versus no treatment was also associated with a reduction in mortality (adjusted OR 0·50; 95% CI 0·37-0·67; p<0·0001). These associations with reduced mortality risk were less pronounced and not significant in children. There was an increase in the mortality hazard rate with each day´s delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset (adjusted hazard ratio [HR 1·23] [95% CI 1·18-1·28]; p<0·0001 for the increasing HR with each day´s delay).  INTERPRETATION:  We advocate early instigation of neuraminidase inhibitor treatment in adults admitted to hospital with suspected or proven influenza infection.","palabras_clave":"Influenza|Neuraminidasa|Inhibidores|Mortalidad"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40202,"idioma_id":5,"titulo":"Pampa solar: un proyecto multidisciplinario para la construcción de un vehículo solar","resumen":"Los sistemas basados en energías limpias y de emisión cero como alternativas de movilidad sustentable aplicadas al transporte urbano son hoy una necesidad y justifican el objetivo de disponer de un vehículo solar como prototipo experimental. así, la iniciativa de un grupo de trabajo constituido por docentes, estudiantes y personal no docente se focalizó en la construcción de un vehículo híbrido experimental motivado por una competencia latinoamericana de autos solares, en la que se validó su desempeño luego de su participación. el prototipo construido fue galardonado con el premio al usomás eficiente de energía solar. En el trabajo se presentan los aspectos constructivos del vehículo y resultados experimentales obtenidos durante la competición.","palabras_clave":"Energía solar|Vehículo híbrido experimental|emisión cero|panel solar"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40203,"idioma_id":4,"titulo":"Molecular and phylogenetic identification of an oil-producing strain of Nannochloropsis oceanica (Eustigmatophyceae) isolated from the southwestern Atlantic coast (Argentina)","resumen":"Screening of local microalgae species with potential for oil production is essential to achieve successful commercial large-scale cultures. In this study, identification of a South American species of Nannochloropsis was carried out using molecular and phylogenetic analyses of chloroplastic and nuclear genes, rcbL and 18S rDNA, respectively. The gene sequences for the studied strain were highly similar to other strains of Nannochloropsis oceanica (100% for 18S rDNA and 99.7% for rbcL) isolated from the Red Sea or Mediterranean Sea (Israel) and from the Pacific Ocean (Japan).","palabras_clave":"NANNOCHLOROPSIS OCEANICA|RBC L|18S RDNA|OIL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40204,"idioma_id":4,"titulo":"Efficacy of oxyclozanide against adult Paramphistomum leydeni in naturally infected sheep","resumen":"tomum leydeni in naturally infected adult sheep. OCZ concentrations in blood stream andgastrointestinal fluids collected from treated animals were also measured. Fifteen P. leydeninaturally infected sheep were randomly divided into two groups: untreated control (n = 5)and treated (n = 10). The treated group was orally drenched with OCZ (20 mg\/kg, day 0). Asecond dose was administered 72 h later. Faecal samples were taken at days 0, +3 and +5.Five sheep from both groups were slaughtered at day +5. At necropsies, rumen, abomasumand small intestine were examined for adult and immature flukes. All recovered flukes werecounted and the treatment efficacy was estimated. Additionally, serum and gastrointestinalfluid content (ruminal, abomasal and small intestine) samples, obtained from five treatedanimals at day +5, were analyzed by HPLC to measure OCZ concentrations. OCZ showedhigh efficacy (99%) against mature P. leydeni. The post-treatment egg reduction was alsohigh after the first dose with values ranging from 98.4% (day +3) to 99.5% (day +5). Thehighest OCZ concentrations were measured in serum (20.7 ± 11.5 g\/mL) followed by thesmall intestinal fluid (6.00 ± 4.50 g\/mL). Very low OCZ concentrations (ranging between0.05 and 0.02 g\/mL) were measured in ruminal and abomasal fluids. OCZ administered tosheep twice (20 mg\/kg) by the oral route was highly efficacious against mature stages of P.leydeni in naturally infected sheep. Despite a high drug concentration at the intestinal fluid,OCZ efficacy against immature stages could not be assessed. OCZ efficacy and assessmentof its concentration profiles in different tissues are considered a contribution to the scarceinformation available on this ruminant fluke.","palabras_clave":"Paramphistomum leydeni|Oxyclozanide|efficacy|sheep"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40205,"idioma_id":4,"titulo":"Genetic diversity and clinical impact of human rhinoviruses in hospitalized and outpatient children with acute respiratory infection, Argentina","resumen":"Background: Human rhinoviruses (HRV) are recognized as a cause of upper and lower acute respiratory infections (ARI). The circulating species and their clinical impact were not described in Argentina. Objectives: To describe the molecular epidemiology of HRV in children and to determine the association of HRV species with outcome and severity. Study design: Hospitalized and outpatients children <6 years old with ARI without comorbidities (n=. 620) were enrolled (2008-2010). Demographic, clinical data and outcome were analyzed. HRV were identified by RT-PCR. Phylogenetic analysis and demographic reconstruction for HRV were performed in selected samples. Results: HRV were detected in 252\/620 (40.6%) of children; 8.5% in viral coinfection. Bronchiolitis (55%) and pneumonia (13%) were the most frequent clinical diagnosis. Of 202 inpatients with HRV: 72% required oxygen supplementation, 11% intensive care unit and 3% mechanical ventilation. HRV were identified as a risk factor for hospitalization (OR: 2.47).All three HRV species were detected being HRV-A (55%) and HRV-C (43%) the most frequent; HRV-B was infrequent (2%). Of 44 sequenced HRV, 30 genotypes were detected. Seven of them were the most prevalent and circulated during limited periods of time. The demographic reconstruction revealed a constant population size and a high turnover rate of genotypes. Demographic and clinical outcome were similar for HRV-A and HRV-C infections. Conclusion: This study highlights the clinical impact of HRV in children without comorbidities as a cause of lower ARI and hospitalization. The high frequency of HRV infections may be associated with the simultaneous circulation of genotypes and their high turnover rate.","palabras_clave":"Human rhinoviruses|Genotypes|Acute respiratory infection|Children|Molecular epidemiology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40206,"idioma_id":4,"titulo":"Temperature explains variable spread rates of the invasive woodwasp Sirex noctilio in the Southern Hemisphere","resumen":"The frequency of introductions of non-indigenous forest insects into new habitats is increasing worldwide, often with profoundly adverse consequences on natural and plantation forest ecosystems. Understanding rates and patterns of spread of invasive forest insects is important for predicting when and where these species will expand their geographical range, with the potential to improve mitigation strategies. The woodwasp Sirex noctilio is a damaging invasive forest insect that kills numerous species of Pinus. Despite encountering highly variable eco-climatic conditions, S. noctilio has arrived and established in exotic pine forest production areas throughout the Southern Hemisphere. In this study, we compiled historical records of S. noctilio invasion to compare spread rates among eight contrasting eco-climatic regions in the Southern Hemisphere and to explore how spread rate is predicted by landscape variation in climate, habitat characteristics, and anthropogenic effects. Spread rates for S. noctilio varied considerably among the invaded regions, ranging from 12 to 82 km per year. Among regions, spread rates of S. noctilio increased with increasing mean annual temperature and isothermality. We hypothesize that temperature may directly or indirectly influence S. noctilio population growth and dispersal, thereby influencing spread rates.","palabras_clave":"EXOTIC PESTS|INVASION ECOLOGY|RANGE EXPANSION |LANDSCAPE ECOLOGY|CLIMATE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40208,"idioma_id":4,"titulo":"A pair production telescope for medium-energy gamma-ray polarimetry","resumen":"a b s t r a c tWe describe the science motivation and development of a pair production telescope for medium-energy (5?200 MeV) gamma-ray polarimetry. Our instrument concept, the Advanced Energetic Pair Telescope (AdEPT), takes advantage of the Three-Dimensional Track Imager, a low-density gaseous time projection chamber, to achieve angular resolution within a factor of two of the pair production kinematics limit (0.6 at 70 MeV), continuum sensitivity comparable with the Fermi-LAT front detector (&lt;3  106 MeV cm2 s1 at 70 MeV), and minimum detectable polarization less than 10% for a 10 mCrab source in 106 s.","palabras_clave":"GAMMA RAYS |PAIR PRODUCTION|ANGULA RESOLUTION|POLARIMETRY SENSITIVITY"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40209,"idioma_id":5,"titulo":"ARGENTINA. REVISTA MENSUAL, 1949-1950 ¿UNA BISAGRA CULTURAL DEL PERONISMO?","resumen":"RESUMEN. Este estudio brinda una lectura de la tradición política peronista, al margen del enfoque estrictamente politológico, poniendo de relieve su heterogeneidad más allá del verticalismo. En la construcción de poder que forja  el peronismo, la prensa escrita se constituye en espacio privilegiado de la disputa por el poder simbólico. Argentina. Revista mensual (1949-1950) impulsada  por el sector nacionalista del Estado, se analiza como expresión de un momento de cambio de rumbo en el peronismo ?que busca renovadas adhesiones- cuando se produce la ?vuelta al campo? y una identidad entre el gobierno, el Estado y el partido. Palabras clave: Peronismo; Cultura- Nacionalismo; Prensa; Revistas.   ARGENTINA. MONTHLY MAGAZINE, FROM 1949 TO 1950 A CULTURAL TURNING POINT OF PERONISM?   ABSTRACT This article analyzes the governmental practices in the National Territory of Misiones. In a context characterized by a lack of autonomy and constraints on citizen participation, it describes and interprets the relationship between rulers and ruled. The objective is to comprehend State?s actions in this territory as practices that control and regulate the every day life and the political, social and economic activities of its inhabitants. These  practices manifest, in many cases, internal contradictions during the consolidation of the argentine National State This study provides a reading of the Peronist political tradition, beyond a strictly political science approach, emphasizing its heterogeneity beyond verticality. Therefore, it considers the press as a privileged space of dispute for symbolic power in the forge of Peronism. Argentina. Monthly Magazine (1949-1950) driven by nationalist sector of the State, is analyzed as an expression of a moment of reversal in Peronism that looks for renewed adhesions, when the 'back to the field' occurs and the government is fused with the State and the Justicialist party.  Key words: Culture; Nationalism; Press; Magazines. ","palabras_clave":"PERONISMO|CULTURA|NACIONALISMO|REVISTAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40210,"idioma_id":5,"titulo":"CONDICIONES DE DESTILACIÓN QUE INFLUYEN EN EL RENDIMIENTO EXTRACTIVO Y COMPOSICIÓN QUÍMICA DEL ACEITE ESENCIAL DE COMINO","resumen":"El comino es una especie inverno-primaveral de amplios usos en la industria alimenticia, también en licorería, perfumería y farmacia. La parte útil de la planta es el fruto semilla que contiene el aceite esencial (AE) responsable de su olor y sabor característicos. En Catamarca, y en general en el Noroeste Argentino, el comino se emplea en el preparado de estofados y guisos, pero su uso más frecuente es en la elaboración del relleno de las empanadas y chorizos criollos, a los que les confiere un particular aroma y sabor. Se produce en los departamentos Santa María, Belén, Pomán, Tinogasta, Andalgalá, Capayán y Valle Viejo, ubicándose, a nivel nacional, entre las primeras provincias productoras. El consumidor final adquiere normalmente el comino molido en las ferias, almacenes, o mercados, siendo menos común encontrar el producto en grano. Sucede que el producto molido puede implicar cierto nivel de fraude al consumidor, dado que en el proceso de molienda se puede adulterar el grano con cantidades elevadas de otras partes de la planta que carecen de propiedades sápido-aromáticas. Además, tanto el producto en grano como el molido, requieren de ciertos cuidados para su adecuada conservación. En contraste a ello se propone el empleo del aceite esencial (AE) de comino que se puede conservar en la heladera en pequeños frascos color caramelo. El empleo del AE presenta múltiples ventajas respecto del producto en grano o molido; una de ellas es que ocupa poco espacio, puesto que 30 o 35 ml de AE equivalen a 1 kg de especia en grano y a 1,5 kg, aproximadamente, del producto molido. Otra ventaja es la higiene, puesto que tanto el comino en grano y aún más el molido, contienen cierta cantidad de tierra y\/o arena (Martínez S. et al, 2004), además de posibles hongos, levaduras o bacterias, que no están presentes en el AE porque es totalmente estéril y limpio. El empleo de AE resolvería problemas relacionados con el espacio para el almacenamiento de grandes volúmenes de especia y su conservación.  La obtención del AE a partir del grano entero o molido requiere de un adecuado manejo de las técnicas extractivas. Los frutos maduros y secos, constituyen la parte útil de la planta de los cuales se extrae, por hidrodestilación, entre 1,5 y 5 ml% de AE, aunque en la mayoría de los casos, va del 2 al 3,5% (Tainter y Grenis, 1993; Quiroga y Luna, 1999; Pérez y Luna, 1983; Código Alimentario Argentino, 1971?C.A.A.). La calidad del comino está dada por la cantidad de AE que contiene el grano y por la composición química de este aceite, siendo el aldehído cumínico el componente mayoritario y el principal responsable de su sabor y aroma característicos. Los factores que mayormente influyen en la cantidad de AE presente en el grano son el genotipo, las características del suelo, las técnicas de cultivo, cosecha y secado, las condiciones de almacenamiento, etc. Por otra parte, no todo el AE contenido en el grano se logra extraer, por cuanto la eficiencia de la destilación varía según las condiciones de trabajo. Estas condiciones también generan variaciones en la composición química del AE por lo que es importante conocer ampliamente el proceso para evitar transformaciones indeseables. La técnica extractiva más eficiente en cuanto al rendimiento y composición química del AE es la hidrodestilación (cohobación sumergida) usando la trampa de Clevenger (Bandoni, 1989). Sin embargo, distintas publicaciones manifiestan la utilización de esta técnica e informan el rendimiento en AE sin detallar las condiciones de trabajo, lo que dificulta la comparación, generando incertidumbre (C.A.A., 1971 op cit; Pérez, 1983; Curioni, 1997; Iacobellis, 2005). Algunas de las variables de la técnica extractiva que influyen en el rendimiento y la composición química del AE son el tiempo de destilación, expresado en horas y la densidad de carga del destilador, la cual se entiende como los gramos de comino molido por cada mililitro de agua que se colocan en el balón de destilación.","palabras_clave":"ACEITE ESENCIAL COMINO|RENDIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40211,"idioma_id":4,"titulo":"Conformation-Independent QSAR on c-Src Tyrosine Kinase Inhibitors","resumen":"The main idea of this work was to find predictive quantitative structure?activity relationships (QSAR) for a wide set of c-Src tyrosine kinase inhibitors, by means of resorting to a conformation-independent representation of the chemical structure. In this way, our attempt was to avoid the availability of X-ray crystallographic structural information of the target. Therefore, in a set composed of 80 pyrrolo-pyrimidine derivatives, 1179 theoretical descriptors were simultaneously analyzed through linear regression models obtained with the replacement method variable subset selection technique. Alternatively, the flexible (activity dependent) descriptor approach was also applied in this study. The models were validated and tested through the use of an external test set of compounds, the leave-group-out cross validation method, Y-randomization and applicability domain analysis.  Our results were compared with previously published ones based on docking analysis and 3D-QSAR. The obtained conformation-independent approach was in good agreement with experimental observations.","palabras_clave":"QSAR theory|Multivariable linear regression analysis|c-Src tyrosine kinase|Structural descriptors"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40212,"idioma_id":5,"titulo":"Planificación estratégica en la Universidad Pública Argentina. Descripción y análisis del proceso de elaboración y del documento resultante del Proyecto Estratégico Institucional de la Universidad Nacional de Luján (P.E.I.). (2009-2012)","resumen":"      El  presente artículo fue escrito con la intención de describir y analizar el Plan  Estratégico Institucional (PEI) 2009-2012 de la Universidad Nacional de Luján,  como documento que exterioriza la Planificación Estratégica elaborada por la  propia comunidad universitaria. Se consideró un caso muy interesante para  explorar ya que, si bien el puntapié para el mismo provino de una demanda externa,  la organización emprendió el proceso de sistematizar y redactar un documento  que devela los antecedentes, las debilidades, las fortalezas y las propuestas  para mejorar la Institución en un horizonte temporal definido. Se pudo observar  la naturaleza en extremo compleja y conflictiva que tiene el proceso de  Planificación Estratégica en cualquier organización, y en particular en las universidades  públicas argentinas, que se caracterizan por ser estructuras profundamente  democráticas.   ","palabras_clave":"Universidad|Estrategia|Planeamiento"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40213,"idioma_id":5,"titulo":"Artesanía en El Siambón: La inserción del diseño en la comunidad local y la proyección a la red de artesanías nacionales","resumen":"La producción artesanal es  un valor cultural que forma parte de la identidad de la comunidad del Siambón y de su área de influencia y que podría asumir un rol destacado en la economía familiar con el agregado de algunos atributos. El presente trabajo se estructuró en torno a esta temática, articulando situaciones  de enseñanza- aprendizaje donde se fusionaron saberes, técnicas y manufactura propios de la región con conocimientos y procesos de diseño propios de la academia. Como punto de partida se realizó un relevamiento de los tipos de artesanías y técnicas y de la cantidad de productores que existen. Las conclusiones en el área textil se incluyeron  dentro del proyecto MCPTAN (Mapa Cultural y Productivo del Textil Artesanal Nacional) emprendimiento que lleva a cabo el INTI junto con diferentes unidades técnicas y académicas del país, entre ellas la UNT a través de un proyecto de extensión de la FAU (Fac. de Arq. y Urbanismo). Confeccionado el mapa local, se seleccionó y trabajó con artesanos del tejido y de la madera. Partiendo de criterios de revalorización y preservación de conocimientos y saberes ancestrales se puso énfasis en la promoción del desarrollo de capacidades locales, la revalorización de las tareas de hilado y tejido artesanal, el uso de teñidos naturales y el rescate de técnicas heredadas. A partir de allí, se diagramaron nuevos productos que incluyeron optimizaciones funcionales, productivas, estéticas o ergonómicas para mejorar la competitividad. La puesta en valor de la producción de objetos artesanales ocupa un lugar importante en el proceso de socialización comunitaria. En ese marco, se fomentó la conformación de un grupo de artesanos locales en búsqueda de alternativas de soluciones integrales, con activa participación en espacios de intercambio de experiencias y en ferias de venta conjunta.","palabras_clave":"artesanía ancestral|valor cultural|enseñanza-aprendizaje|espacios de intercambio"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40214,"idioma_id":4,"titulo":"Campylobacter fetus subsp. venerealis adhesion to MDBK cells","resumen":"Campylobacter fetus subsp. venerealis adhesion to MDBK cellsAdhesión de Campylobacter fetus subsp. venerealis a células MDBKMaría L. Chiapparronea,b,*, Pedro E. Moránc, Hilda M. Echevarríab, Pedro Sotob, FernandoA. Paolicchid, María Catenaba Consejo Nacional de Investigaciones Científi cas y Técnicas, Ciudad Autónoma de Buenos Aires, República Argentinab Laboratorio de Microbiología Clínica y Experimental, NACT, SAMP, Unidad Ej ecutora de CONICET (CIVETAN), Facultad deCiencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Provincia de Buenos Aires,República Argentinac Laboratorio de Virología, SAMP, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provinciade Buenos Aires, Tandil, Provincia de Buenos Aires, República Argentinad Instituto Nacional de Tecnología Agropecuaria, EEA Balcarce, Departamento de Producción Animal, Laboratoriode Bacteriología, Balcarce, Provincia de Buenos AiresRecibido el 29 de abril de 2014; aceptado el 6 de mayo de 2014Members of the genus Campylobacter are recognized ascausative agents of infectious diseases in humans andanimals throughout the world. These bacteria are curved tospiral rods and have a single polar fl agellum. Campylobacterfetus subsp. venerealis and Campylobacter fetus subsp.fetus are the causative agents of bovine genitalcampylobacteriosis, one of the most important venerealdiseases in Argentina, which characteristically producesembryonic death and occasional abortion1.Regarding Campylobacter pathogenesis, there is limitedknowledge about the mechanisms involved in host-bacteriainteraction in the venereal environment, adhesion,chemotaxis or tissue tropism4.Campylobacter fetus is highly adapted to mucosalsurfaces. Bacterial adhesion is an important initial step ininfection. Pathogens use surface-located adhesins tointeract with specifi c host cell receptors. Although somebacterial structures involved in the adhesion process arestill unknown, there is evidence that the lipopolysaccharideand the fl agellum participate in bacterial adherence. Thefl agellum also enables bacterial movement through themucus4.The challenge of cell lines such as HeLa, Hep-2, CHO,VERO, MDBK has allowed the evaluation of different speciesof Campylobacter strains isolated from humans andanimals3,5. Cell adhesion and invasion for differentCampylobacter species have been confi rmed; howeverinvasion has not been demostrated for C. fetus2.C. fetus subsp. venerealis adhesion to MDBK cells wasanalyzed and confi rmed by optical microscopy (Figs. 1 and2) and scanning electron microscopy (Figs. 3 and 4). It wasobserved that the bacterium attaches by the apical portioninvolving the fl agellum in the adhesion, which could indicatethe presence of adhesins on it.References1. Brenner DJ, Krieg NR, Staley JT. Campylobacter. In: Staley JT,Chairman, Boone DR, Vice Chairman, Brenner DJ, De Vos P,Garrity GM, Goodfellow M, Krieg NR, Rainey FA, Schleifer KH,editors. Bergey´s Manual of Systematic Bacteriology, 2nd ed.USA: Editorial Board, 2005, p. 1145-60.2. Catena M. Campilobacteriosis genital bovina: inmunopatogeniade la mortalidad embrionaria. Tesis doctoral para obtener elgrado académico de Doctor en Ciencia Animal. 2002. Facultadde Ciencias Veterinarias. UNCPBA.3. Chiapparrone ML, Catena M, Rodríguez E, Echevarría H,Monteavaro C, Morán P, Arroyo G, Soto P. Evaluación de laadhesión de Campylobacter fetus venerealis en diferenteslíneas celulares. XIII Jornadas Argentinas de Microbiología,2008, p. 181, Rosario. Santa Fe, Argentina.4. Joens LA, Haesebrouck F, Pasmans F. Campylobacter andHelicobacter. In: Gyles CL, Prescott JF, Songer G, Thoen CO,editors. Pathogenesis of bacterial infections in animals. 4th ed.USA: Wiley-Blackwell, 2010, p. 483-501.5. Prasad KN, Dhole TN, Ayyagari A. Adherence, invasion andcytotoxin assay of Campylobacter jejuni in HeLa and HEp-2Cells. J Diarrhoeal Dis Res. 1996;4:255-259.Figures 1 and 2 Observation of Campylobacter fetus subsp. venerealis adhered to MDBK cells. Giemsa stain, 100X.Figures 3 and 4 Observation by scanning electron microscopy of Campylobacter fetus subsp. venerealis adhered to MDBK cells.","palabras_clave":"CAMPYLOBACTER FETUS|ADHESION |MDBK CELLS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40215,"idioma_id":4,"titulo":"Strategy Based on Multiple Objectives and Null Space for the Formation of Mobile Robots and Dynamic Obstacle Avoidance","resumen":"In this paper, a new algorithm for controlling mobile robot flexible formation based on multiple control objectives is presented. The strategy includes the use of null space for shape and posture control. The obstacle avoidance strategy is based on the definition of fictitious potential energy. The primary objective established is to shape control and obstacle avoidance, whereas the secondary objective includes the posture control and trajectory tracking of the robot formation. Stability analysis of the proposed control system is proven. Simulation results show the performance of the proposed controllers.","palabras_clave":"Formación de robots|Evasión de obstáculos|Función potencial|Seguimiento de trayectoria|Epacio nulo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40216,"idioma_id":5,"titulo":"Mantenimiento Perfectivo en un Gestor de Contenidos. Una Experiencia para la Especificación de Consultas Dinámicas","resumen":"Los Sistemas Gestores de Contenidos o CMS son ampliamente aplicados en una diversidad de soluciones para mediar la comunicación con los usuarios finales. En este trabajo se expone una experiencia de personalización de un CMS de libre distribución considerada ésta como un mantenimiento perfectivo, abordando las actividades que propone estándar IEEE 1219 para gestionar dicho proceso.        ","palabras_clave":"ciclo de vida|gestión del mantenimiento|metodologías|gestores de contenido"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40217,"idioma_id":5,"titulo":"Evaluación de la Accesibilidad en Dos Sitios Bancarios Nacionales Dependientes de la Administración Pública","resumen":"&nbsp;En este trabajo se aborda una de las medidas de&nbsp; calidad de la Ingeniería del Software: laAccesibilidad Web y su&nbsp; validación en eldominio de dos instituciones del sector de&nbsp;finanzas públicas de alcance nacional. Esta medida se convirtió&nbsp; en varios países del mundo en unapreocupación porque atañe&nbsp; directamente ala posibilidad de acceso de los ciudadanos a la&nbsp;información, comunicación y servicios (públicos y privados)&nbsp; ofrecidos a través de la web. Por loexpuesto, es necesario que los&nbsp; sitios dela administración pública, en este caso particular, los&nbsp; bancarios carezcan de problemas de acceso alos contenidos, lo&nbsp; que se lograsiguiendo los estándares propuestos por el Consorcio&nbsp; W3C. Se describe la metodología orientada ala evaluación del&nbsp; cumplimiento de laspautas WCAG 2.0, propuestas por el&nbsp; mencionadoConsorcio. La indagación demuestra la necesidad de&nbsp; fomentar la aplicación de las mencionadaspautas en el proceso&nbsp; de desarrollo desitios bancarios.&nbsp; ","palabras_clave":"Accesibilidad Web,| Ingeniería del Software|medición en sitios web bancarios"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40218,"idioma_id":5,"titulo":"MEDICIONES DE ALGUNOS PARAMETROS HIGROTERMICOS Y AMBIENTALES EN EL EDIFICIO DE LA FACULTAD DE RECURSOS NATURALES DE LA UNIVERSIDAD NACIONAL DE FORMOSA","resumen":"Se comentan  los avances de un proyecto de investigación en desarrollo en la Universidad  Nacional de Formosa (UNaF), titulado 'Determinación de las condiciones higrotérmico  ? lumínicas y de calidad del aire de edificios del campus de la UNaF.  Diagnóstico en función de normativa de habitabilidad y URE'. Dicho proyecto está realizando una  evaluación del desempeño higrotérmico - lumínico y de calidad del aire interior  de los edificios más representativos del Campus de la UNaF, lo que permitiría definir  premisas básicas para determinar políticas institucionales para el ?Uso  Racional de la Energía?  y para el saneamiento ambiental en su edificación. Tomado como caso el edificio de la Facultad de Recursos Naturales  (FRN), se exponen los resultados de mediciones de temperatura en una muestra de  4 aulas del mismo, así como de mediciones de calidad de aire interior. El  objetivo fue detectar posibles problemas de disconfort y de contaminación  ambiental, e iniciar un diagnóstico de situación.","palabras_clave":"EDIFICIOS EDUCATIVOS |AMBIENTE|ENERGÍA|TEMPERATURAS Y MONITOREOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40219,"idioma_id":5,"titulo":"Revista institucional de la FAU-UNNE: aporte a la interacción de la universidad con el medio regional","resumen":"Esta comunicación presenta un proyecto  editorial, recientemente aprobado por las autoridades de la FAU-UNNE impulsado  por su Secretaría de Investigación: el de una nueva revista institucional de esta  Facultad. &nbsp;Se exponen los fundamentos,  las secciones que la compondrán y el equipo que trabajará en la realización. Esta  iniciativa tiene como propósito ampliar y profundizar la proyección de la Institución  y generar un ámbito de calidad científica y técnica para el debate de la  arquitectura, el urbanismo y el diseño.","palabras_clave":"GESTIÓN UNIVERSITARIA|PROYECTO EDITORIAL|INTERACCIÓN CON EL MEDIO REGIONAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40220,"idioma_id":5,"titulo":"CUERPO, MELANCOLÍA Y VIDA PRECARIA CRÍTICA DE LA VIOLENCIA ESTATAL EN EL GIRO ÉTICO DE JUDITH BUTLER","resumen":"ResumenEl trabajo aborda la noción de sujeto melancólico expuesto enla obra Judith Butler, y cómo este sujeto opera en laconstrucción de género y la ciudadanía política necesariaspara pensar la vulnerabilidad y el cuidado. La reflexión deButler realiza un desplazamiento ético luego de los hechos del9\/11, y su tarea en las últimas obras se encargan de analizarla vulnerabilidad diferenciada existente en la sociedad, dondese reconocen qué cuerpos pueden ser habitados y cuáles no,qué vidas merecen ser lloradas y cuáles deben serclausuradas. Recuperar esos planteos, permite alumbrar elproblema de la melancolía de género, y entender de quémodo la violencia del Estado maximiza la vulnerabilidad de lasvidas no legitimadas en las convenciones del sujeto político. Asu vez, nos interroga sobre los límites del cuidado y laprotección en la sociedad actual.","palabras_clave":"CUERPO|CRÍTICA|VULNERABILIDAD|CUIDADO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40221,"idioma_id":4,"titulo":"In vitro Inhibition of Leishmania braziliensis Promastigotes Growth by a Fluconazole Microemulsion","resumen":"Cutaneous leishmaniasis (CL) is the most prevalent form of the disease caused by the parasites Leishmania.  However, effective topical treatments for the disease are lacking. Fluconazole (FLZ) is an antifungal agent that  inhibits a key enzyme for the production of ergosterol, the main sterol in membranes of fungi and parasites. An in vitro  evaluation of antileishmanial activity of a microemulsion intended for topical use, with FLZ as active pharmaceutical  ingredient, was performed.  The formulation effectively inhibited L. braziliensis promastigotes growth. This study provides baseline data  about the efficacy of FLZ microemulsion on L. braziliensis promastigotes. Previous reports had shown poor activity  of the drug, so this result highlighted the role of the vehicle.  Although further work is needed, this semisolid dosage form could be useful for the local treatment of CL in the  New World. It is also interesting to mention the importance of repositioning well-known drugs for new uses to offer  treatments more quickly, particularly for this disease that greatly affects public health of poor regions.","palabras_clave":"Fluconazole|Cutaneous Leishmaniasis|Microemulsion|Topical treatment"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40222,"idioma_id":4,"titulo":"FoxA4 Favours Notochord Formation by Inhibiting Contiguous Mesodermal Fates and Restricts Anterior Neural Development in Xenopus Embryos","resumen":"In vertebrates, the embryonic dorsal midline is a crucial signalling centre that patterns the surrounding tissues during development. Members of the FoxA subfamily of transcription factors are expressed in the structures that compose this centre. Foxa2 is essential for dorsal midline development in mammals, since knock-out mouse embryos lack a definitive node, notochord and floor plate. The related gene foxA4 is only present in amphibians. Expression begins in the blastula ? chordin and ?noggin expressing centre (BCNE) and is later restricted to the dorsal midline derivatives of the Spemann?s organiser. It was suggested that the early functions of mammalian foxa2 are carried out by foxA4 in frogs, but functional experiments were needed to test this hypothesis. Here, we show that some important dorsal midline functions of mammalian foxa2 are exerted by foxA4 in Xenopus. We provide new evidence that the latter prevents the respecification of dorsal midline precursors towards contiguous fates, inhibiting prechordal and paraxial mesoderm development in favour of the notochord. In addition, we show that foxA4 is required for the correct regionalisation and maintenance of the central nervous system. FoxA4 participates in constraining the prospective rostral forebrain territory during neural specification and is necessary for the correct segregation of the most anterior ectodermal derivatives, such as the cement gland and the pituitary anlagen. Moreover, the early expression of foxA4 in the BCNE (which contains precursors of the whole forebrain and most of the midbrain and hindbrain) is directly required to restrict anterior neural development.","palabras_clave":"dorsal midline|BCNE|Spemman-Mangold organizer|foxA4"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40223,"idioma_id":5,"titulo":"El mal de ojo como enfermedad: Elitelore y Folklore en Iberoamérica","resumen":"Revisamos los marcos conceptuales del mal de ojo, destacando que tales teorías dejan de lado sus manifestaciones como enfermedad, la caracterización de los ojeadores y de las víctimas en términos de la antigua medicina científica. Los autores sostienen que el mal de ojo en Iberoamérica es el nombre de una enfermedad, cuyos contenidos y teorías etiológicas, exceden el dominio humano, incluyendo ojeadores animales.","palabras_clave":"Folk|Poder|Enfermedad|Daño"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40224,"idioma_id":5,"titulo":"Diseño y validación de la Escala CapPsi para medir capital psicológico","resumen":"El objetivo del presente estudio fue el desarrollo y validación de una escala para medir capital psicológico en adultos.Los ítems iniciales se elaboraron sobre la base de la revisión bibliográfica, entrevistas con empleados y consultas conespecialistas. Inicialmente se efectuó una prueba piloto que permitió realizar ajustes conceptuales y semánticos de losítems. La escala fue administrada a 382 empleados, conjuntamente con las medidas de desempeño laboral, comportamientosorganizacionales contraproducentes y satisfacción general. Asimismo, se estudió la validez factorial exploratoria yconfirmatoria; además de la confiabilidad como consistencia interna a través del coeficiente alpha de Cronbach. Losresultados mostraron la existencia de cuatro factores con satisfactorios niveles de validez y confiabilidad, los que fueronrotulados como: Esperanza (&#945; = .87), Optimismo (&#945; = .91), Resiliencia (&#945; = .84) y Autoeficacia (&#945; = .79). La escala cumplecon los criterios psicométricos exigidos y puede ser empleada como herramienta de diagnóstico y gestión organizacional","palabras_clave":"CAPITAL PSICOLÓGICO|ESCALA|ADULTOS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40225,"idioma_id":4,"titulo":"Stress in wild Greater Rhea populations: effects of agricultural activities on seasonal excreted glucocorticoid metabolite levels","resumen":"In recent years, wild populations of Greater  Rhea (Rhea americana) have declined drastically, due  mainly to the conversion of grassland into cropland as a  result of intensive, specialized agricultural practices. In this  study we test the potential stressful effects of agricultural  activities on this ratite by assessing their adrenocortical  response. Specifically, we compared fecal glucocorticoid  metabolite (FGM) levels of rheas living in two areas under  very different land use: grasslands mainly used for cattle  grazing and agro-ecosystems intensively used for crop  production. Groups of rheas were observed during  45 50 min from a distance of approximately 1 km to avoid  any potential disturbance. Therefore, no matching of each  fecal sample with a particular sex or individual within the  group was possible. Radioimmunoassay of fecal samples  from 269 individuals indicated no significant differences in  mean concentrations of FGM from the two habitats sampled.  In the agro-ecosystem we found no overall effect of  agricultural practices on the birds? FGM levels. However,  during the dry season FGM concentrations were significantly  higher, which may represent a stress response to the  low availability of food in the post-harvesting season. In  contrast, no increase in FGM levels was registered during  the dry season in the grassland, where food was available  throughout the year. In this environment the highest  increases in FGM levels coincided with the reproductive  period, likely due to the frequent agonist encounters  between males at this time of the year. Our findings,  therefore, suggest that the agricultural practices have to be  viewed as chronic environmental stressors for Greater Rhea  populations living under such conditions. The present  results support earlier research showing detrimental  impacts of agricultural activities on this species, which  inhabits the most productive regions of South America.","palabras_clave":"Field endocrinology|Greater Rhea|Stress|Fecal glucocorticoid metabolites"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40226,"idioma_id":4,"titulo":"Efficiency of antipredator training in captive-bred greater rheas reintroduced into the wild","resumen":"Ver Full text.","palabras_clave":"RHEA|ANTIPREDATOR TRAINING|PUMA|TRANSLOCATION|SURVIVAL"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40227,"idioma_id":4,"titulo":"Diet of wild boar (Sus scrofa) in a protected area of Argentina: the importance of baiting","resumen":"The wild boar is an invasive mammal in Argentina that generates habitat alteration, predation, and competition that threaten several native species due to its flexible andbroad diet and its rooting behavior. We evaluated the diet of wild boar in El Palmar National Park (EPNP), assessing its composition, seasonality, and importance of baiting. Vegetable matter represented the major component of the diet, where corn was the most abundant food item, which is used as bait to hunt wild boars. Animal remains were also abundant andmostly consisted of birds. Wild boar diet exhibited marked seasonality that seems related to food availability, such as the occurrence of fruits in summer. Currently, the importance ofbait in the diet could support and complement the diet of wild boar and improve their reproduction triggering the population growth. Also, the impacts on native biodiversity may be hidden due to the constant food subsidy of corn. We recommend the implementation of other control methods such as hunting with dogs or traps and the use of alternative baits, asodor baits, to avoid the supplemental feeding, or finally, if corn baiting is continuous, we suggest regulating their quantity and frequency. Further studies on wild boar diet andbaiting methods should be conducted due to its multiple implications on wild boar  populations and native ecosystems.","palabras_clave":"CONSERVATION|CONTROL METHODS|CORN |FERAL PIG|SEASONAL VARIATION|SUPPLEMENTARY FEEDING"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40228,"idioma_id":4,"titulo":"Prevalence of hypertension in rural iberoamerica an the caribbean","resumen":"Hypertension and  cardiovascular risk factors are widespread in developing countries, but little  is known about cardiovascular risk profiles in rural communities from  Iberoamérica and the Caribbean. We aimed to evaluate of the peer-reviewed  literature on the prevalence of hypertension in rural populations from  Iberoamérica and the Caribbean published from 1990 to 2012. A bibliographic  search was conducted in MEDLINE, SCIELO and LILACS databases. We include  population based studies in which prevalence of hypertension in adults were  reported. We identified 30 peer reviewed publications that reported the  prevalence of hypertension over 33.143 patients. The crude hypertension  prevalence reported from rural Iberoamérica was 32.6% (95% CI: 31.4-32.5%;  range: 1.8-52%). The prevalence of hypertension was lower in aboriginal  populations than in other rural communities (19.5% vs. 36%). Only 9 studies  assessed the awareness, treatment and level of control of hypertension (54%,  57% and 14% respectively). The most prevalent cardiovascular risk factor was  abdominal obesity (39%) and overweight (39%). Hypertension is of public health  importance in rural Iberoamérica and the Caribbean, with evidence of  considerable under-diagnosis, treatment, and control. There is an urgent need  to develop strategies to prevent, detect, treat, and control hypertension  effectively in this region","palabras_clave":"Iberoamerica|Hypertension|Rural|Epidemiology"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40229,"idioma_id":5,"titulo":"Medición de la velocidad de la onda del pulso en la práctica clínica","resumen":"    La medición de la velocidad de la onda del pulso (VOP) es una herramienta muy útil para la evaluación    de la rigidez arterial en el ámbito asistencial ya que es de fácil aplicación, de carácter no invasivo y    muchas técnicas y dispositivos comerciales han sido desarrollados para su cuantificación. Los valores de    referencia de la VOP provienen en su mayoría de registros metacéntricos de Asia, África, Estados Unidos,    Australia y Europa y aunque diversos estudios realizados en poblaciones hispánicas y latinas han mostrado    diferencias significativas en el tamaño estructura y rigidez arterial en pequeñas y grandes arterias,    existen pocos estudios basados en población que hayan evaluado la rigidez arterial en poblaciones la    República Argentina o en Sud América.    Está ampliamente documentado que la rigidez aórtica evaluada a través de la VOP carótido-femoral    puede predecir la ocurrencia de eventos cardiovasculares y mortalidad aún después de considerar los    demás factores de riesgo cardiovasculares tradicionales. El valor predictivo de la VOP parece ser mayor    en gente joven y no sería modificado por la presencia de hipertensión, tabaquismo, el género y la diabetes    o enfermedad renal. Esto debe estimular la realización de intervenciones que puedan cuantificar    las alteraciones de las propiedades elásticas de las arterias lo que tendría un gran impacto en mejorar    la tasa de éxito del tratamiento de la hipertensión arterial.","palabras_clave":"Hipertension|Rigidez Arterial|Pronostico"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40230,"idioma_id":4,"titulo":"Heart Failure Care in Low- and Middle-Income Countries:","resumen":"Background: Heart failure places a significant burden on patients and health systems in high-income countries. However,                      information about its burden in low- and middle-income countries (LMICs) is scant. We thus set out to review both                      published and unpublished information on the presentation, causes, management, and outcomes of heart failure in LMICs.                      Methods and Findings: Medline, Embase, Global Health Database, and World Health Organization regional databases were                      searched for studies from LMICs published between 1 January 1995 and 30 March 2014. Additional unpublished data were                      requested from investigators and international heart failure experts. We identified 42 studies that provided relevant information                      on acute hospital care (25 LMICs; 232,550 patients) and 11 studies on the management of chronic heart failure in primary care or                      outpatient settings (14 LMICs; 5,358 patients). The mean age of patients studied ranged from 42 y in Cameroon and Ghana to                      75 y in Argentina, and mean age in studies largely correlated with the human development index of the country in which they                      were conducted (r =0.71, p,0.001). Overall, ischaemic heart disease was the main reported cause of heart failure in all regions                      except Africa and the Americas, where hypertension was predominant. Taking both thosemanaged acutely in hospital and those                      in non-acute outpatient or community settings together, 57% (95% confidence interval [CI]: 49%?64%) of patients were treated                      with angiotensin-converting enzyme inhibitors, 34% (95% CI: 28%?41%) with beta-blockers, and 32% (95% CI: 25%?39%) with                      mineralocorticoid receptor antagonists. Mean inpatient stay was 10 d, ranging from 3 d in India to 23 d in China. Acute heart                      failure accounted for 2.2% (range: 0.3%?7.7%) of total hospital admissions, and mean in-hospital mortality was 8% (95% CI: 6%?                      10%). There was substantial variation between studies (p,0.001 across all variables), and most data were from urban tertiary                      referral centres. Only one population-based study assessing incidence and\/or prevalence of heart failure was identified.                      Conclusions: The presentation, underlying causes, management, and outcomes of heart failure vary substantially across                      LMICs. On average, the use of evidence-based medications tends to be suboptimal. Better strategies for heart failure                      surveillance and management in LMICs are needed.","palabras_clave":"Heart Failure|Low income countries|Meta-Analysis|Systematic Review"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40231,"idioma_id":4,"titulo":"REFERENCE VALUES OF PULSE WAVE VELOCITY IN HEALTHY PEOPLE FROM AN RURAL AND URBAN ARGENTINEAN POPULATION.","resumen":"                                    In medical practice the reference values of arterial stiffness came from multicenter registries obtained in Asia, USA, Australia and Europe. Pulse wave velocity (PWV) is the gold standard method for arterial stiffness quantification, however in South America there are few population based studies.                         In this research PWV was measured in healthy asymptomatic and normotensive subjects without history of hypertension in first-degree relatives.                         Normal PWV and the 95% confidence intervals values were obtained in 780 subjects (39.8 ± 18.5 years) divided into 7 age groups (10-98 years). The mean PWV found was 6.84 m\/s ±1.65. PWV increases linearly with aging with a high degree of correlation (r2 = 0.61; p &lt;0.05) with low dispersion in younger subjects. PWV progressively increases 6-8% with each decade of life; this tendency is more pronounced after 50 years. A significant increase of PWV over 50 years old was demonstrated.                                     This is the first population-based study from urban and rural people of Argentina that provides normal values of the PWV in healthy, normotensive subjects without family history of hypertension. Moreover, the age dependence of PWV values was confirmed.             ","palabras_clave":"Pulse wave velocity|Arterial Stiffness|Argentine Population"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40232,"idioma_id":5,"titulo":"Diversidad de cepas de Agrobacterium rubi aisladas de arándanos","resumen":"The diversity of a collection of Agrobacterium rubi strains isolated from Blueberries from different regions of Argentina was studied by conventional microbiological tests and molecular techniques. Results from biochemical and physiological reactions, as well as from rep-PCR and RFLP analysis of PCR-amplifi ed 23S rDNA showed high phenotypic and genotypic intraspecific variation.","palabras_clave":"AGROBACTERIUM RUBI|AGALLAS|ARANDANOS|DIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40233,"idioma_id":5,"titulo":"EVALUACIÓN DE PÉRDIDAS VOLUMÉTRICAS EN RECIPIENTES DE ALMACENAMIENTO DE COMBUSTIBLES","resumen":"Resumen ? Diversas normativas establecen que los recipientes de almacenamiento de combustibles deben serauditados periódicamente para determinar su seguridad. Entre los diversos tipos de controles se encuentran inspeccionesvisuales, controles de espesor de las paredes de recipientes y tuberías y pruebas de estanqueidad[1,2,4,5]. La normativa establece el tipo de ensayo a realizar, incorporando lo especificado por normas internacionalestales como las normas sobre petróleo (API) [3] y las normas medioambientales (EPA). En general laspruebas prevén la carga de los recipientes con un gas inerte (nitrógeno) a una presión determinada, la que seevalúa durante un cierto tiempo (por ejemplo 30 minutos). Por otro lado las mismas normas establecen que elmétodo de ensayo debe determinar con cierto grado de certeza la magnitud de las eventuales pérdidas, en litrosde combustible por hora, y que la metodología debe tener una sensibilidad tal que pueda detectar desde una cantidadmínima de pérdidas (por ejemplo 0,2 litros por hora). Dado que el ensayo determina un flujo de gas inerte,se deben corregir los valores obtenidos para el mismo, de manera que se refleje adecuadamente la pérdida quese produciría si el tanque hubiese estado lleno de combustible. Este trabajo muestra el desarrollo de una metodologíapara la determinación del volumen de pérdidas de combustible a partir de los resultados de ensayos realizadoscon un gas inerte.","palabras_clave":"ESTANQUEIDAD|ALMACENAMIENTO DE COMBUSTIBLES|PERDIDAS VOLUMETRICAS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40234,"idioma_id":4,"titulo":"Human Memory B cells isolated from blood and tonsils are functionally distinctive","resumen":"Human  B cell studies in vitro have routinely used B lymphocytes purified from  spleen, blood or tonsils irrespective of potential differences in their  immunological traits. In this study, we compared the functional responses of  total and memory B cells (CD19+ and CD19+\/CD27+)  isolated from blood and tonsils to different stimuli. Peripheral B cells showed  enhanced survival and proliferation compared with their tonsillar equivalents  when stimulated for 10 days. Stimulated B cells from both tissues secreted  significantly greater amounts of cytokines than unstimulated controls  demonstrating their functional responsiveness. Analysis of CD27 expression over  time indicated that the conditions that promoted survival and proliferation of  peripheral memory B cells (Bmem), caused massive tonsillar Bmem  death. Purified tonsillar Bmem failed to expand but rapidly  differentiated in antibody secreting cells (ASC) and subsequently underwent  apoptosis. In contrast, circulating Bmem showed delayed activation  and differentiation, but exhibited a longer lifespan and active proliferation. In  addition, short-term stimulation of tonsillar Bmem resulted in the  production of more IgG than their peripheral counterparts. At later time  points, however, IgG production from the different B cells was reversed. Our  findings imply that tissue located and peripheral Bmem have distinct  behaviours, indicating organ dependent functional responses that should not be  generalizable to all Bmem. This work provides a greater  understanding of how Bmem location is coupled to specialized roles  of B lymphocytes.","palabras_clave":"B cell |Mucosal|Sistemic|Immunological memory"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40235,"idioma_id":4,"titulo":"Neurologic dysfunction and genotoxicity induced by low levels of chlorpyrifos","resumen":"Chlorpyrifos  (CPF) is an organophosphorus cholinesterase inhibitor widely used as an  insecticide. Neuro and genotoxicity of this agent were evaluated following  daily subcutaneous injections at 0.1, 1 and 10 mg\/kg or its vehicle to  laboratory rats during one week, at the end of which somatosensory evoked  potentials (SEP) and power spectrum of the electroencephalogram (EEGp) were  recorded under urethane anesthesia. In another group of conscious animals,  auditory startle reflex (ASR) was evaluated followed, after euthanasia, with  measurements of plasma B-esterases, and genotoxicity with the alkaline comet  assay (ACA) at the same CPF doses. The results indicated a CPF dose related  inhibition of B-esterases. Enhanced inhibition of the ASR by a subthreshold  pre-pulse was observed at all doses and ACA showed a significant higher DNA  damage than vehicle controls in animals exposed to 10 mg\/kg CPF. A trend to  higher frequencies of EEGp and an increase in amplitude of the first negative  wave of the SEP were found at all doses. The first positive wave of the SEP  decreased at the CPF dose of 10 mg\/kg. In summary, a shift to higher EEG  frequencies and alterations of somatosensory and auditory input to the central  nervous system were sensitive manifestations of CPF toxicity, associated with  depression of B-esterases. The changes in electrical activity of the cerebral  cortex and DNA damage observed at doses that do not elicit overt toxicity may  be useful in the detection of CPF exposure before clinical signs appear.","palabras_clave":"Neurologic dysfunction|Chlorpyrifos|Rat"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40237,"idioma_id":5,"titulo":"Experiencias y trayectorias educativas en la transferencia de conocimientos","resumen":"Este artículo dialoga con el proyecto de investigación ?Narrativas biográficas en torno a las experiencias y trayectorias educativas de graduados y graduadas de la Licenciatura en Comunicación social (UNLP) sobre los vínculos que las tesis propician en la transferencia de conocimientos? gestado en el 2013, a partir del cual consideramos pertinente analizar las experiencias de transferencia y las diferentes percepciones que tienen sobre ellas los y las jóvenes que se han graduado, en tanto investigadores\/productores de conocimiento, en el marco de la realización de su tesis de grado para la finalización de carrera como proceso educativo, para enriquecer la mirada sobre cuáles son los vínculos comunicacionales, procesos de transferencia y aprendizajes significativos en los espacios educativos.","palabras_clave":"EXPERIENCIAS|TRAYECTORIAS|TRANSFERENCIA|TESIS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40238,"idioma_id":4,"titulo":"Threatened gastropods under the evolutionary genetic species concept: redescription and new species of the genus Aylacostoma (Gastropoda: Thiaridae) from High Paraná River (Argentina-Paraguay)","resumen":"The genus Aylacostoma Spix, 1827, is mainly endemic to South America, and comprises about 30 nominal species, most of which were described based solely on conchological features following the typological approaches of most of the 19th and the mid-20th century authors. Here, we redescribe Aylacostoma chloroticum Hylton Scott, 1954,and describe Aylacostoma brunneum sp. nov. from the High Paraná River (Argentina-Paraguay) by means of morphological and molecular characters. Both are threatened species currently included into an ongoing ex situ conservation programme, as their habitats have disappeared because of damming and the filling up of the Yacyretá Reservoir in the early 1990s. We used DNA sequences from cytochrome b and cytochrome oxidase subunit I (COI) genes to estimate their genetic distances, and the COI sequences were also used to assess their specific status under the evolutionary genetic species concept by means of the K\/theta method. Our results clearly demonstrate that both must be recognized as evolutionary genetic species, despite only minor differences in morphological characters other than in the shells.","palabras_clave":"ANATOMY|ASEXUALLY REPRODUCING TAXA|ENDANGERED FRESHWATER SNAILS|EX SITU CONSERVATION PROGRAM|MITOCHONDRIAL DNA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40239,"idioma_id":4,"titulo":"Optimal capacity and buffer size estimation under generalized Markov Fluids models and QoS parameters","resumen":"Quality of service (QoS) for internet traffic management requires good traffic models and good estimation of sharing network resource. A link of a network processes all traffic and it is designed with certain capacity C and buffer size B. A Generalized Markov Fluid model (GMFM), introduced by Marrón (2012), is assumed for the sources because it describes in a versatile way the traffic, allows estimation based on traffic traces, and also consistent effective bandwidth (EB) estimation can be done. QoS, interpreted as buffer overflow probability, can be estimated for GMFM through the EB estimation and solving the optimization problem presented in Courcoubetis and Siris, the so-called inf-sup formulas. In this work, we implement a code to solve the inf -sup problem and other optimization related with it, that allow us to do traffic engineering in links of data networks to calculate both, minimum capacity required when QoS and buffer size are given or minimum buffer size required when QoS and capacity are given.","palabras_clave":"Markov sources|Traffic analysis|Effective bandwidth"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40240,"idioma_id":4,"titulo":"Long term consequences of in utero endocrine disruptors exposure on male offspring development","resumen":"Early life events have long lasting impacts on tissue structure and function. It is accepted that there is an association between environmental challenge during pregnancy and later pathophysiology, a concept that has been named ?developmental programming? The environmental adversity acts on specific tissues of the foetus during sensitive periods in its development to change developmental trajectories and thus their organisation and function. During the prenatal period, gonadal steroid hormones (i.e. oestrogens and androgens) organise the developing brain by changing the architecture of several neural substrates which later in puberty are activated by the gonadal steroids surge in a directed manner. Endocrine disruptors may distort or shift the organism &#769;s normal patterns of response to environmental or internal conditions and if present during the gestational period, severe morphological and functional impairments have been observed in the offpring. In this mini-review we will summarize the literature available on endocrine disruptors (ED) exposure during pregnancy and the influence on the outcome of the male offspring. Additionally, the effects of the non-steroidal ED flutamide will be discussed in view of the simmilarities detected with the prenatal stress effects observed on male offspring.","palabras_clave":"DEVELOPMENTAL PROGRAMMING |GONADAL STEROID HORMONES|MALE RAT OFFSPRING|DOPAMINERGIC SYSTEM|PRENATAL STRESS|FLUTAMIDE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40241,"idioma_id":4,"titulo":"Evaluation of Pseudomonas chlororaphis subsp. aurantiaca SR1 for growth promotion of soybean and for control of Macrophomina phaseolina","resumen":"Pseudomonas chlororaphis subsp. aurantiaca SR1 was evaluated for control of  Macrophomina phaseolina in vitro and in soybean plants, for growth promotion of  soybean plants and for production of antifungal compounds. Strain SR1 caused a  significant inhibition of M. phaseolina in vitro and reduced damping-off in the in  15 vivo assays. In addition, strain SR1 significantly increased shoot and root length  and shoot and root dry weight of soybean plants in M. phaseolina infested soil, as  compared to control plants in infested soil. Fragments for the phenazine-  1-carboxylic acid, pyrrolnitrin and hydrogen cyanide encoding genes were  amplified from the DNA of strain SR1 after PCR assays with specific primers. AQ1  20 Thus, this study establishes that P. chlororaphis subsp. aurantiaca SR1 provides  control of M. phaseolina in vivo and suggests that strain SR1 might be applied as  an effective biocontrol agent to protect soybean plants from this phytopathogen","palabras_clave":"Pseudomonas|growth promotion|soybean|Macrophomina phaseolina"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40242,"idioma_id":5,"titulo":"Jeanne Favret- Saada: ?Ser Afectado? como medio de conocimiento en el trabajo de campo antropológico","resumen":"El texto que aquí presentamos y que hemos traducido tiene por objeto cumplir con una serie de propósitos. En primer lugar, poner a disposición un texto de relevancia teórica y metodológica entre el público de habla hispana que no ha podido acceder a él a través de sus versiones en lengua francesa e inglesa. En segundo lugar, a través de la traducción de «Être affecté» - «Ser afectado»- nos proponemos introducir la problemática específica que aborda la autora: el análisis simbólico y el estudio representacional apenas dan cuenta de los fenómenos cifrados en la sorcellerie, que exceden, en mucho, la dinámica simbólica organizada en torno al ritual y el lenguaje representacional. Los actos de embrujamiento\/desembrujamiento son producidos por y producen una lógica cuya fuerza no proviene de las palabras pronunciadas ni las acciones emprendidas por quienes protagonizan la brujería. Esa fuerza, según Favret-Saada, es anterior a la representación e impregna los símbolos que intentan comunicar algún significado. Se trata del «afecto», quantum energético de tipo inconsciente, que sólo es aprehensible para el\/la etnógrafo\/a a través de su experimentación directa. De ahí que para estudiar la brujería sea preciso no sólo «comprenderla» sino, además, dejarse afectar por su lógica de funcionamiento. De ello surgen varias interrogantes: ¿Qué tipo de dispositivo metodológico se debería introducir para investigar fenómenos de estas características? ¿Ser afectado\/a significa que el\/la etnógrafo\/a experimenta el mismo fenómeno que los\/as nativos\/as? ¿Se podría producir «conocimiento»? ¿De qué tipo? Al aplicarse este método de trabajo ¿Cómo es recolocado el distanciamiento clásico entre el sujeto y el objeto?","palabras_clave":"SER AFECTADO|TRABAJO DE CAMPO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40243,"idioma_id":5,"titulo":"APORTES para la construcción de los paisajes agrícolas en la región de Fiambalá, Tinogasta, Catamarca: NUEVAS EVIDENCIAS","resumen":"Presentamos nuevas evidencias de sistemas agrícolas prehispánicos emplazados en la región de Fiambalá en el oeste del departamento de Tinogasta (Catamarca, Argentina): Suri Potrero, Los Morteros y El Puesto. Integramos los nuevos registros a los conocidos para aportar a la configuración del paisaje agrícola regional. Este se caracteriza por presentar un predominio de sistemas agrícolas de canchones ?emplazados en terrazas fluviales en distintos ambientes? sobre los de terraza en ladera. Las formas de espacialidad se mantienen en el tiempo, tanto en el primero como en el segundo milenio, lo cual sugiere que las condiciones sociales y políticas de producción no sufrieron importantes transformaciones.","palabras_clave":"SISTEMAS AGRICOLAS|PAISAJES AGRICOLAS|ORGANIZACION DEL TRABAJO|TINOGASTA, CATAMARCA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40244,"idioma_id":5,"titulo":"Producir energia","resumen":"¿Como producir energía accesible, capaz de alimentar la red domestica, que permita reducir el impacto ambiental y, a la ves, sirva como plataforma de formación profesional? Esta preguntas movieron a la facultad de Ingeniería del Ejercito a desarrollar un convertidor que trasforma la corriente continua almacenada en las baterías en corriente alternas. sus responsables explican el corazón de este proyecto, que condensan en un mismo lugar investigación, trasferencia tecnológica y cuidado del medio ambiente, y apunta a un fuerte impacto tanto académico como económico.","palabras_clave":"Producir Energia"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40245,"idioma_id":4,"titulo":"Effects of field-realistic doses of glyphosate on honeybee appetitive behaviour","resumen":"Glyphosate (GLY) is a broad-spectrum herbicide used for weed control. The sub-lethal impact of GLY on non-target organisms such as insect pollinators has not yet been evaluated. Apis mellifera is the main pollinator in agricultural environments and is a well-known model for behavioural research. Honeybees are also accurate biosensors of environmental pollutants and their appetitive behavioural response is a suitable tool with which to test sub-lethal effects of agrochemicals. We studied the effects of field-realistic doses of GLY on honeybees exposed chronically or acutely to the herbicide. We focused on sucrose sensitivity, elemental and non-elemental associative olfactory conditioning of the proboscis extension response (PER), andforaging-related behaviour. We found a reduced sensitivity to sucrose and learning performance for the groups chronically exposed to GLY concentrations within the range of recommended doses. When olfactory PER conditioning was performed with sucrose reward with the same GLY concentrations (acute exposure), elemental learningand short-term memory retention decreased significantly compared with controls. Non-elemental associative learning was also impaired by an acute exposure to GLY traces. Altogether, these results imply that GLY at concentrations found in agro-ecosystems as a result of standard spraying can reduce sensitivity to nectar reward and impairassociative learning in honeybees. However, no effect on foragingrelated behaviour was found. Therefore, we speculate that successful forager bees could become a source of constant inflow of nectar with GLY traces that could then be distributed among nestmates, stored in the hive and have long-term negative consequences on colony performance.","palabras_clave":"Apis mellifera|Glyphosate|Sub-lethal effects|Associative learning, Sensitivity to reward"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40246,"idioma_id":4,"titulo":"Hydraulic parameters estimation from well logging resistivity and geoelectrical measurements","resumen":"In this paper, a methodology is suggested for deriving hydraulic parameters, such as hydraulic conductivity or transmissivity combining classical hydrogeological data with geophysical measurements. Estimates values of transmissivity and conductivity, with this approach, can reduce uncertainties in numerical model calibration and improve data coverage, reducing time and cost of a hydrogeological investigation at a regional scale. The conventional estimation of hydrogeological parameters needs to be done by analyzing wells data or laboratory measurements. Furthermore, to make a regional survey many wells should be considered, and the location of each one plays an important role in the interpretation stage. For this reason, the use of geoelectrical methods arises as an effective complementary technique, especially in developing countries where it is necessary to optimize resources. By combining hydraulic parameters from pumping tests and electrical resistivity from well logging profiles, it was possible to adjust three empirical laws in a semi-confined alluvial aquifer in the northeast of the province of Buenos Aires (Argentina). These relations were also tested to be used with surficial geoelectrical data. The hydraulic conductivity and transmissivity estimated in porous material were according to expected values for the region (20 m\/day; 457 m2\/day), and are very consistent with previous results from other authors (25 m\/day and 500 m2\/day). The methodology described could be used with similar data sets and applied to other areas with similar hydrogeological conditions.","palabras_clave":"GEOPHYSICAL|HYDRAULIC|GROUNDWATER|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40247,"idioma_id":4,"titulo":"Ophtalmic artery microcatheterization for research purposes in pigs. A technical note.","resumen":"ABSTRACT Purpose: To describe a technique for micro catheterization of the external ophthalmic artery (EO) in pigs for investigational and training purposes.  METHODS:  Carotid angiography was performed in seven male domestic pigs. The external ophthalmic artery was reached with a microcatheter in order to administer a neoplastic drug in the eye.  RESULTS:  The external ophthalmic artery could be found arising from the infraorbital (IO) artery in the bend of the internal maxillary (IM) artery. It could be reached in every animal.  CONCLUSION:  Following anatomic landmarks of the external carotid (EC) artery the ophthalmic artery can be easily reached and catheterized for training and investigational purposes.","palabras_clave":"pigs|catetherization"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40248,"idioma_id":4,"titulo":"Local and Systemic Toxicity of Intravitreal Melphalan for Vitreous Seeding in Retinoblastoma: A Preclinical and Clinical Study","resumen":"Purpose: Intravitreal melphalan is emerging as an effective treatment for refractory vitreous seeds in retinoblastoma, but there is limited understanding regarding its toxicity. This study evaluates the retinal and systemic toxicity of intravitreal melphalan in retinoblastoma patients, with preclinical validation in a rabbit model.  Design: Clinical and preclinical, prospective, cohort study.  Participants: In the clinical study, 16 patient eyes received 107 intravitreal injections of 30 mg melphalan given weekly, a median of 6.5 times (range, 5e8). In the animal study, 12 New Zealand\/Dutch Belt pigmented rabbits were given 3 weekly injections of 15 mg of intravitreal melphalan or vehicle to the right eye.  Methods: Electroretinogram (ERG) responses were recorded in both humans and rabbits. For the clinical  study, ERG responses were recorded at baseline, immediately before each injection, and at each follow-up visit; 82 of these studies were deemed evaluable. Median follow-up time was 5.2 months (range, 1e11). Complete  blood counts (CBCs) were obtained on the day of injection at 46 patient visits. In the animal study, ERG responses were obtained along with fluorescein angiography, CBCs, and melphalan plasma concentration. After  humane killing, the histopathology of the eyes was evaluated.  Main Outcome Measures: For the clinical study, we measured peak-to-peak ERG amplitudes in response to 30-Hz photopic flicker stimulation with comparisons between ERG studies before and after intravitreal melphalan.  For the animal study, we collected ERG parameters before and after intravitreal melphalan injections with histopathologic findings.  Results: By linear regression analysis, over the course of weekly intravitreal injections in retinoblastoma patients, for every additional injection, the ERG amplitude decreased by approximately 5.8 mV. The ERG remained stable once the treatment course was completed. In retinoblastoma patients, there were no grade 3 or 4 hematologic events. One week after the second injection in rabbits, the a- and b-wave amplitude declined significantly in themelphalan treated eyes compared with vehicle-treated eyes (P&lt;0.05). Histopathology revealed severely atrophic retina.  Conclusion: Weekly injections of 30 mg of melphalan can result in a decreased ERG response, which is indicative of retinal toxicity. These findings are confirmed at an equivalent dose in rabbit eyes by ERG measurements and by histopathologic evidence of severe retinal damage. Systemic toxicity with intravitreal melphalan at these doses in humans or rabbits was not detected.","palabras_clave":"Electroretinogram |retinoblastoma|intravitreal|intrarterial|chemotherapy|retina|ophthalmic artery|carotid artery|melphalan"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40249,"idioma_id":4,"titulo":"Therapeutic monitoring of pediatric renal transplant patients with conversion to generic cyclosporin","resumen":"Abstract Background Cyclosporin is a calcineurin inhibitor widely used in renal transplant patients to prevent organ rejection. Several position papers have been published but no reports on the practical experience in pediatric patients undergoing conversion between cyclosporin innovator and generic products are available. Objective To evaluate the pharmacokinetics and safety as part of therapeutic monitoring of cyclosporin in renal transplant pediatric patients who switch from the innovator to the genericformulation in Argentina. Setting Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina. Methods Stable pediatric renal transplant patients (6 months post-transplant) switched from the innovator to the generic formulation of cyclosporin microemulsion capsule. Cyclosporin pharmacokinetic parameters were obtained while taking the innovator and after starting with the generic formulation. Blood samples were drawn before and 1, 2, and 3 h after drug administration and subsequently quantified. Pharmacokinetic parameters were obtained by means of a Bayesian approach. Main outcomes measure Cyclosporin pharmacokinetic parameters (area under the curve, AUC; Blood concentration after 2 h, C2), adverse events and graft rejection. Results A total of 12 patients were included.Median (range) age and time post-transplant were 10.7 years (6.5?17.7) and 8.3 years (3.4?14.0), respectively. Two patients or their parents did not consent to the switch. Median (range) dose normalized cyclosporin AUC and C2 were 1.15 (mg*h\/L)\/mg\/kg (0.72?3.0) and 265.5 (ng\/ml)\/mg\/kg (120.8?725.7), respectively, on theinnovator therapy and 1.05 (mg*h\/L)\/mg\/kg (0.54?2.22) and 317.1 (ng\/ml)\/mg\/kg (116.7?564.7) for the generic drug after the switch. The median (range) percentage of change in the AUC and C2 when switching between formulations were 16.7 % (0.7?56.7) and 13.1 % (3.7?68.6), respectively. No significant changes in serum creatinine levels were registered when comparing before and after substitution of products. Adverse events (number of events) recorded 5 months before and after the switch included hirsutism (2), hypertension (2), and gingival hyperplasia (1). Conclusion Conversion of cyclosporin from innovator brand to generic in pediatric renal transplant patients needs to be closely monitored.","palabras_clave":"CYCLOSPORINE|GENERICS|PEDIATRICS|PHARMACOKINETICS|RENAL TRANSPLANT"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40250,"idioma_id":4,"titulo":"Non-rhizobial peanut nodule bacteria promote maize (Zea mays L.) and peanut  (Arachis hypogaea L.) growth in a simulated crop rotation system","resumen":"The term ?Plant Growth Promoting Bacteria? or PGPB designates a diverse group of prokaryotic  microorganisms that can increase plant growth by diverse mechanisms. Some PGPB are capable of  colonizing root inner tissues and constitute endophytic populations. Incorporation of these micro-  organisms into agricultural practices may constitute a valid alternative to increase crop productivity in a  sustainable and environmentally friendly production scheme, reducing the application of agrochemicals.  In a previous work, we described the characterization of bacteria belonging to Pseudomonas,Enterobacter  and Klebsiella obtained from surface sterilized peanut nodules. In addition, we showed that some of these  isolates were able to promote several peanut growth and symbiotic parameters. Bounded to the results  from this particular study, and considering their potential ability to interact with different plant species,  in this work we assessed the effects of their inoculation in maize (Zea mays L.) under controlled  conditions. Furthermore, we analyzed growth promotion in a simulated peanut?maize crop rotation  system. Finally, we determined the plant growth promoting (PGP) properties present in the isolates.  Results indicated that all bacteria are able to significantly promote maize and peanut growth, and that  they also displayed plant growth promotion activity in maize growing in a peanut?maize crop rotation  sequence.","palabras_clave":"MAIZE|PEANUT|PGPB|CROP ROTATION|ENDOPHYTES"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40251,"idioma_id":5,"titulo":"El dispositivo desnudo","resumen":"Revista del Centro de Investigaciones Artísticas.(Director: Roberto Jacoby)Esta publicación se erige como un soporte editorial que desclasifica los documentos de las actividades realizadas en el CIA y se explaya en contenidos afines.Este trabajo querría ser una crónica filosófica de la experiencia del taller de Cine Expandido, dictado por Claudio Caldini. A partir de un ejercicio performático de dialogo entre las posibilidades del espectro cromático intentamos abordar nuevamente las viejas premisas de la ontología del cine. Al abrir un proyector de Super 8 y entender cómo funciona, el cineasta muestra cómo se mueve la cinta provocando un detenimiento intermitente en la salida de la imagen. Este juego de luz y oscuridad, a la vez operación manual y una herramienta poética, recupera la noción de imagen cinematográfica como espectral.En este artículo nos proponemos recorrer las consecuencias de semejante retorno.","palabras_clave":"super 8|CALDINI|CINE EXPERIMENTAL|CINE EXPANDIDO"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40252,"idioma_id":5,"titulo":"Las críticas expansiones de la crítica","resumen":"    En un artículo de la&nbsp; Encyclopedia of Journalism de 2009, se concluye que la crítica  parece estar ante una crisis de existencia que incluso puede conllevar su  desaparición, asediada por un lado por la situación de la prensa escrita  impresa y por otro por la expansión de los blogs y otras formas de la  escritura instaladas fundamentalmente en Internet.    En  este trabajo se intenta demostrar que desde principios del siglo XX han  aparecido otros discursos que, de diversos modos, desplegaron algunos de los  rasgos de la crítica de artes visuales y funcionaron en la discursividad social  de un modo semejante a ella, lo que no ha determinado sin embargo su  desaparición. Por el contrario, se puede definir esa convivencia con la figura  de ?universo en expansión?. No obstante, el doble sentido del título de este  trabajo permite hablar tanto de una expansión de la crítica como de una  expansión crítica, lo que se hace necesario ante el hecho de que, siendo la  crítica un género periodístico, todavía se debe evaluar si la denominada crisis  de la prensa impresa y las nuevas formas de la discursividad en la red pueden  afectarla como no lo han hecho las otras que se examinan aquí. ","palabras_clave":"crítica de arte|expansiones|manifiesto artístico |curaduría"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40254,"idioma_id":5,"titulo":"La cuestión educativa ¿Una política pública? Análisis de políticas públicas educativas en la comuna de San Pablo y alrededores","resumen":"El objetivo de este trabajo de investigaci+on es poder dimensionar el actual sistema educativo de la provincia de Tucumán en específico la comunidad de San Pablo y sus alrededores. Dicha investigación se enmarca dentro del proyecto IES 309 'La inclusión social en las políticas públicas educativas. El caso Tucumán 2009-2013' de la Universidad San Pablo-Tucumán. Las políticas públicas de inclusión social constituyen un desafío en la reformulación teórica, en la gestión y en las prácticas para la región latinoamericana , es decir, en su formulación e implementación. Las políticas sociales de la región están cambiando en la primera década del siglo XXI y se ha iniciado un proceso de construcción que indica un cambio de paradigma dejando el asistencialismo focalizado hacia la universalización como derecho de ciudadanía. La política educativa ha presentado un giro en relación al acceso de la población, sin embargo, los logros presentan diferente magnitud según los distintos ciclos. A pesar de estos aumentos en las tasas de cobertura, uno de los problemas comunes de los sistemas educativos latinoamericanos son las diferencias en la calidad de los procesos de enseñanza y aprendizaje que transitan los alumnos, de tal forma que el ingreso en las escuelas no implica ineludiblemente que los niños aprendan. Los datos obtenidos dentro de esta investigación a partir de la aplicación de una encuesta propia en la comuna, permiten comprender como se estructura el sistema educativo y a partir de allí como se configuran las relaciones sociales educativas en nuestra unidad de estudio. Es necesario recalcar, que dada la limitada evidencia de impacto de estas políticas, el documento subraya algunas inquietudes, sobre la efectividad-coste y los impactos educativos que estos programas tienen al momento de reflejar los índices de calidad e inclusión.","palabras_clave":"Políticas Públicas|Inclusión Social|Educación"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40255,"idioma_id":4,"titulo":"Effects of climatic conditions on sex ratios in nests of broad snouted caiman","resumen":"Caiman latirostris has temperature-dependent sex determination and is potentiallysusceptible to environmental temperature fluctuations and, thus, to the globalclimate change phenomena. Considering the potential consequences of increasingtemperatures for Ca. latirostris offspring, we examined the effects of climaticconditions on sex ratios produced by caimans in wild nests and in particular howclimate variables affect nest temperature and the percentage of females produced.We also explored the potential consequences of a hypothetic 0.5 and 1.0°Cincrease in nest temperature on caiman populations. The proportion of femalesproduced from nests in the wild varied among reproductive seasons, as mean nesttemperatures varied between 27.1 and 33.9°C. However, after seven seasons thesex ratio biased toward females, and only during extreme events (strong El NiñoSouthern Oscillation event, La Niña) was there a reduction in the percentage offemales produced in the wild. In the hypothetic scenarios of global warming, wepredict a decrease of unisexual female nests, with nests containing both sexes orunisexual male nests becoming more frequent. Entire clutches might be lost if nesttemperatures rise above 34.5°C for extended periods. However, it is possible thatfemales modify their nesting timing and behavior to select thermally suitable nestenvironments","palabras_clave":"Caiman latirostris|climate change|nesting|sex determination|temperature"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40256,"idioma_id":5,"titulo":"Cambios estructurales en cáscaras de huevos de Caiman latirostris","resumen":"El éxito reproductivo de Caiman latirostris puede estar afectado por las modificaciones que se producen en las cáscaras durante el período de incubación de los huevos. Resulta importante conocer las estructuras que conforman la cáscara y los cambios que en ella ocurren. En este estudio se presentan descripciones de la estructura (forma y tamaño del huevo, ornamentación, espesor y estructura de la cáscara, tipo de unidades de cáscara, densidad y tamaño de poros), y evidencias de los cambios producidos durante la incubación. Las modificaciones más importantes halladas en las cáscaras fueron: el adelgazamiento de la capa calcárea y el aumento del tamaño de los poros. La mayor parte de las modificaciones de la cáscara se produjeron principalmente a partir del segundo y tercer tercio del período de incubación.","palabras_clave":"Yacaré overo|incubación|huevos|densidad de poros|espesor"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40257,"idioma_id":4,"titulo":"Towards male individualization with rapidly mutating Y-chromosomal STRs","resumen":"Relevant for various areas of human genetics, Y-chromosomal STRs (Y-STRs) are  commonly used for testing close paternal relationships amongst individuals and populations,  and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot  resolve individuals and populations completely. Here, 52 centers generated quality-controlled  data of 13 rapidly-mutating (RM) Y-STRs in 14,644 related and unrelated males from 111  worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely  individualized. Haplotype diversity was extremely high (global: 0.9999985, regional:  0.99919-0.9999988). Haplotype sharing between populations was almost absent except for  six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally  rare (0.8% non-unique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and  highest in endogamous groups (14.3%). AMOVA revealed 99.98% of variation within  populations, 0.018% among populations within groups, and 0.002% among groups. Of the  2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including  27% of the 2,378 fathers\/son pairs. Relative to Yfiler, haplotype diversity was increased in  86% of the populations tested and overall male relative differentiation was raised by 23.5%.  Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and  related males and provides a reference database.","palabras_clave":"RAPIDLY MUTATING|Y CHROMOSOMAL|SHORT TANDEM REPEAT|FORENSIC"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40258,"idioma_id":4,"titulo":"REVIEWING PREPROCESSING AND FEATURE EXTRACTION TECHNIQUES FOR RETINAL BLOOD VESSELS SEGMENTATION IN FUNDUS IMAGES","resumen":"Several ophthalmological and cardiovascular diseases?such as diabetic and hypertensive retinopathies, choroidal neovascularization, arteriosclerosis, among others?can be diagnosed by analysing the structure of the retinal vasculature. Such analysis require to count with precise segmentation of blood  vessels, being manual delineation tedious and time-consuming. Various algorithms for automatic blood vessel segmentation have been proposed in the last years, most based on supervised methods. These approaches deal with the automatic detection of retinal blood vessel features and non-vessel features by learning on the basis of a training set of manually segmented reference images. Performance of such methods is usually determined by the features capability of discriminating vessels from other anatomical or pathological structures. In this work, we present a review of different preprocessing and feature extraction techniques for blood vessel segmentation in retinal images. Using a linear Support Vector Machine as the segmentation approach, we study the behaviour of several state-of-the-art preprocessing and feature extraction techniques in the detection of retinal vasculature, summarizing their computation and results. Finally, we propose a standard methodology to evaluate and compare blood vessel segmentation algorithms. A publicly available data set of fundus images is employed for evaluation, and our results are compared against other state-of-the-art approaches.","palabras_clave":"Fundus imaging|Blood vessels segmentation|Feature engineering|Support Vector Machines"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40259,"idioma_id":4,"titulo":"Adiponectin predicts MMP-2 activity independently of obesity","resumen":"BACKGROUND: Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, have been identified in atherosclerotic plaques and have been directly associated with plaque remodelling and vulnerability. Cardiovascular disease (CVD) is related to insulin resistance (IR) and obesity, characterized by changes in plasma levels of inflammatory markers, such as adiponectin and C-reactive protein (CRP). Our aim was to evaluate the impact of both proteins on MMP-2 and MMP-9 behaviour in individuals with IR. MATERIALS AND METHODS: Plasma MMP-2 and MMP-9 activity, adiponectin and hs-CRP concentration and lipoprotein profile were determined in 52 patients with metabolic syndrome (MS) and 27 controls. RESULTS: Patients with MS presented significantly higher MMP-2 activity than controls: 0?95 ± 0?12 vs. 0?77 ± 0?15 relative units (RU) (P < 0?001), while MMP-9 activity was not detectable. MMP-2 activity decreased across quartiles of adiponectin, being significantly reduced in individuals with the highest levels of adiponectin in compared with the lowest levels (0?75 ± 0?17 vs. 0?93 ± 0?09 RU, P < 0?005). This difference persisted significant after adjusting by obesity markers. MMP-2 activity was significantly increased in individuals with the highest levels (G3) compared with those with the lowest levels (G1) of hs-CRP (0?94 ± 0?12 vs. 0?86 ± 0?12, P = 0?041) CONCLUSION: In this study, we observed that adiponectin levels predicted MMP-2 plasma activity independently of obesity. This finding suggests that the inflammatory process, associated with the highest CVD risk, would be involved in MMPs vascular production.","palabras_clave":"MMP-2|adiponectin|obesity"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40260,"idioma_id":4,"titulo":"Life events are positively associated with luteinizing hormone in middle age adult men. Role of cortisol as a third variable.","resumen":"Previous studies have tested the relationship between chronic stress and sex hormones, but inconsistent results have been found. One possibility is that this association may depend on other biological factors. This study examined the relationship between stressful life events (LE) and sex hormones in men, and whether cortisol is involved in this relationship. From a total number of 2906 men who completed a screening for the early detection of prostate cancer, 139 healthy men (mean&#8201;±&#8201;SD age, 57.8&#8201;±&#8201;5.7 years) were included in this study. Participants were assessed with the Holmes and Rahe questionnaire in relation to their experience of LE during the previous 1-5 years. Salivary and serum cortisol was measured at 08:00-09:00&#8201;h, as well as luteinizing hormone (LH), total testosterone, epinephrine (E) and norepinephrine (NE). LE weight sum and LE number positively correlated with LH (r&#8201;=&#8201;0.293, p&#8201;=&#8201;0.004; r&#8201;=&#8201;0.220, p&#8201;=&#8201;0.031, respectively). In a multiple regression analysis, LE-sum explained an additional and significant 10.4% of the variance in LH levels, after statistically controlling for the effects of age, waist circumference (WC) and BMI (F(1,90)&#8201;=&#8201;6.61, p&#8201;&lt;&#8201;0.05). Importantly, cortisol interacted with LE in relation to total testosterone. In men with high cortisol values (&#8805;15.4&#8201;µg\/dl), there was a statistically significant positive relationship between LE number and total testosterone levels (p&#8201;=&#8201;0.05), while LE were unrelated to total testosterone in men with low cortisol. LE correlated with sex hormones, predicting LH values, and in men with high cortisol levels shows a possible moderator effect of cortisol on the relationship between LE and total testosterone.","palabras_clave":"life events|LH|cortisol"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40261,"idioma_id":4,"titulo":"Fractional type integral operators on variable Hardy spaces","resumen":"Given certain n×n invertible matrices A&#8321;,..., A_{m} and 0&#8804;&#945;<n, in this paper we obtain the H^{p(.)}(R&#8319;)&#8594;L^{q(.)}(R&#8319;) boundedness of the integral operator with kernel k(x,y)=|x-A&#8321;y|^{-&#945;&#8321;}...|x-A_{m}y|^{-&#945;_{m}}, where &#945;&#8321;+...+&#945;_{m}=n-&#945; and p(.), q(.) are exponent functions satisfying log-Hölder continuity conditions locally and at infinity related by (1\/(q(.)))=(1\/(p(.)))-(&#945;\/n).  We also obtain the H^{p(.)}(R&#8319;)&#8594;H^{q(.)}(R&#8319;) boundedness of the Riesz potential operator.","palabras_clave":"Hardy|spaces|variable |exponents"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40262,"idioma_id":5,"titulo":"Algunos aspectos relevantes en el diseño y construcción de bases aisladas para aerogeneradores","resumen":"        El presente trabajo expone algunos  aspectos relevantes en el diseño y construcción de bases aisladas para  aerogeneradores. Se indican criterios de diseño y tareas en la etapa  constructiva. Se desarrolla un análisis de la geometría y su incidencia en las  variables de diseño, evaluando presiones, armadura requerida, rigidez  rotacional, fatiga de materiales, entre otras. Finalmente, se extraen  conclusiones referidas a las gráficas obtenidas y tareas relacionadas con la  construcción.  ","palabras_clave":"Fundaciones|Aerogeneradores|Hormigón armado"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40263,"idioma_id":4,"titulo":"Proapoptotic and anti-invasive activity of Rac1 small molecule inhibitors on malignant glioma cells","resumen":"P { margin-bottom: 0.08in; direction: ltr; color: rgb(0, 0, 0); widows: 2; orphans: 2; }A:link { color: rgb(0, 0, 255); }    Malignant  gliomas are characterized by an intrinsic ability to invade diffusely  throughout the normal brain tissue. This feature contributes mainly  to the failure of existing therapies. Deregulation of small GTPases  signaling, in particular Rac1 activity, play a key role in the  invasive phenotype of gliomas. Here we report the effect of  ZINC69391, a specific Rac1 inhibitor developed by our group, on human  glioma cell lines LN229 and U-87 MG. ZINC69391 is able to interfere  the interaction of Rac1 with Dock180, a relevant Rac1 activator in  glioma invasion and to reduce Rac1-GTP levels. The kinase Pak1, a  downstream effector of Dock180?Rac1 signaling, was also  downregulated upon ZINC69391 treatment. ZINC69391 reduced cell  proliferation, arrested cells in G1 phase and triggered apoptosis in  glioma cells.  Importantly, ZINC69391 dramatically affected cell  migration and invasion in vitro,  interfering with actin cytoskeleton dynamics. We also evaluated the  effect of analog 1A-116, compound derived from ZINC693291 structure.  1A-116 showed an improved antiproliferative and anti-invasive  activity on glioma cells. These  findings encourage further preclinical  testing in clinically relevant animal models.   ","palabras_clave":"Glioma| Rac1|invasion|Rho GTPases"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40264,"idioma_id":5,"titulo":"Editorial","resumen":"Editorial del N° 17 de la Revista Argentina de Ciencia Política","palabras_clave":"TRADUCCIÓN|LITERARIA|DOSSIER|LINGÜÍSTICA"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40265,"idioma_id":4,"titulo":"Computational Analysis of the maximum power point for GaAs sub-cells in InGaP\/GaAs\/Ge triple-junction space solar cells","resumen":"The radiation resistance in InGaP\/GaAs\/Ge triple-junction solar cells is limited by that of the middle GaAs sub-cell. In this work, the electrical performance degradation of different GaAs sub-cells under 1 MeV electron irradiation at fluences below 4 × 1015 cm&#8722;2 has been analyzed by means of a computer simulation. The numerical simulations have been carried out using the onedimensional device modeling program PC1D. The effects of the base and emitter carrier concentrations of the p- and n-type GaAs structures on the maximum power point have been researched using a radiative recombination lifetime, a damage constant for the minority carrier lifetime and carrier removal rate models. An analytical model has been proposed, which is useful to either determine the maximum exposure time or select the appropriate device in order to ensure that the electrical parameters of different GaAs sub-cells will have a satisfactory response to radiation since they will be kept above 80% with respect to the non-irradiated values.","palabras_clave":"ELECTRON IRRADIATION|MAXIMUM POWER POINT|SOLAR CELLS|COMPUTER SIMULATION"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40266,"idioma_id":5,"titulo":"Aplicación de una encuesta sobre recorridos y prácticas lectoras en alumnos del CBC de la UBA. Avance de resultados?","resumen":"              El artículo presenta resultados  parciales de una encuesta sobre recorridos y prácticas lectoras de alumnos del  primer año de la Universidad de Buenos Aires. La encuesta, elaborada a partir  de los aportes de la sociología de la lectura, buscó obtener datos para evaluar  la incidencia las prácticas lectoras históricas y actuales en el desempeño &nbsp;estudiantes del nivel superior, que en un alto  porcentaje no alcanzan los objetivos de lectura pautados por las cátedras. El  análisis cuantitativo y cualitativo realizado permite caracterizar al estudiante  como un lector ?medio básico?, con una representación de pertenencia a la  cultura escrita, que privilegia la lectura literaria y periodística, y que  representa el leer como práctica emotiva e identitaria. Estas representaciones  son atribuidas a una matriz escolar que al reiterar los mismos modos de  aproximación a la lectura, no ha invitado al alumno a familiarizarse con géneros  y experiencias de lectura variadas que contribuyen a la formación de un lector que  continúe sus estudios en la universidad.  ","palabras_clave":"sociología de la lectura |didáctica de la lectura|encuestas"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40267,"idioma_id":5,"titulo":"Las dinámicas del capital transnacional en América del Sur y los ?nuevos? patrones de dependencia: tendencia de re-primarización exportadora en el siglo XXI","resumen":"El presente artículo indaga acerca de la articulación entre las tendencias globales del capital que han favorecido un nuevo proceso de dependencia económica en los países de América del Sur y los diversos modelos de desarrollo a escala nacional. A través de un análisis cuantitativo de variables que dan cuenta de las fases iniciales del ciclo del capital en los países de la región, el trabajo pretende identificarlas características diferenciales entre países en el siglo xxi. De esta manera, se aborda la problemática de la nueva dependencia como una tendencia global que, sin embargo, es mediada por la emergencia de nuevos proyectos de desarrollo a escala nacional.","palabras_clave":"capital transnacional |dependencia|reprimarizacion|proyectos de desarrollo"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40268,"idioma_id":4,"titulo":"Self-energy effects in cuprates and the dome-shaped behavior of the superconducting critical temperature","resumen":"Hole doped cuprates show a superconducting critical temperature Tc which follows an universal dome-shaped behavior as function of doping. It is believed that the origin of superconductivity in cuprates is entangled with the physics of the pseudogap phase. An open discussion is whether thesource of superconductivity is the same that causes the pseudogap&nbsp; properties. The t-J model treated in large-N expansion shows d-wave superconductivity triggered by non-retarded interactions, and aninstability of the paramagnetic state to a flux phase or d-wave charge density wave (d-CDW) state. In this paper we show that self-energy effects near d-CDW instability may lead to a dome-shaped behavior of Tc . In addition, it is also shown that these self-energy contributions may describe several properties observed in the pseudogap phase. In this picture, although fluctuations responsible for the pseudogap properties leads to a dome-shaped behavior, they are not involved in pairing which is mainly non-retarded.","palabras_clave":"CUPRATE SUPERCONDUCTORS|HOLE-DOPED|PSEUDOGAP REGIME|SUPERCONDUCTIVITY PHASE DIAGRAMS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40269,"idioma_id":4,"titulo":"Cloprostenol treatment of feline open cervix pyometra","resumen":"Treatment with cloprostenol, a prostaglandin synthetic analogue, was evaluated in five queens with open-cervix  pyometra. Cloprostenol was administered (5 &#956;g\/kg body weight SC) on 3 consecutive days and amoxicillin (20 mg\/  kg body weight IM) on 7 consecutive days. Transient post-injection reactions caused by cloprostenol administration  included diarrhea, vomiting and vocalizations. Reactions began as quickly as 10 mins after cloprostenol administration  and lasted as long as 30 mins. All queens improved clinically after cloprostenol treatment and remained healthy  until the end of the study, 1 year after treatment. All queens resumed normal estrous cycles without further treatment  and two (40%) delivered a normal litter. In conclusion, use of cloprostenol is an acceptable treatment for opencervix  pyometra in queens.","palabras_clave":"CLOPROSTENOL|OPEN-CERVIX PYOMETRA|QUEEN"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40270,"idioma_id":4,"titulo":"Subhaloes gone Notts: subhaloes as tracers of the dark matter halo shape","resumen":"We study the shapes of subhalo distributions from four dark-matter-only simulations of Milky Way-type haloes. Comparing the shapes derived from the subhalo distributions at high resolution to those of the underlying dark matter fields, we find the former to be more triaxial if the analysis is restricted to massive subhaloes. For three of the four analysed haloes, the increased triaxiality of the distributions of massive subhaloes can be explained by a systematic effect caused by the low number of objects. Subhaloes of the fourth halo show indications for anisotropic accretion via their strong triaxial distribution and orbit alignment with respect to the dark matter field. These results are independent of the employed subhalo finder. Comparing the shape of the observed Milky Way satellite distribution to those of high-resolution subhalo samples from simulations, we find agreement for samples of bright satellites, but significant deviations if faint satellites are included in the analysis. These deviations might result from observational incompleteness.","palabras_clave":"METHODS: NUMERICAL|GALAXIES: HALOES|COSMOLOGY: MISCELLANEOUS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40271,"idioma_id":4,"titulo":"Stochastic angular momentum slews and flips and their effect on discs in galaxy formation models","resumen":"The angular momentum of galactic discs in semi-analytic models of galaxy formation is usually updated in time as material is accreted to the disc by adopting a constant dimensionless spin parameter and little attention is paid to the effects of accretion with misaligned angular momenta. These effects are the subject of this paper, where we adopt a Monte Carlo simulation for the changes in the direction of the angular momentum of a galaxy disc as it accretes matter based on accurate measurements from dark-matter haloes in the Millennium II simulation. In our semi-analytic model implementation, the flips seen in the dark-matter haloes are assumed to be the same for the cold baryons; however, we also assume that in the latter the flip also entails a difficulty for the disc to increase its angular momentum which causes the disc to become smaller relative to a no-flip case. This makes star formation to occur faster, especially in low-mass galaxies at all redshifts allowing galaxies to reach higher stellar masses faster. We adopt a new condition for the triggering of starbursts during mergers. As these produce the largest flips it is natural to adopt the disc instability criterion to evaluate the triggering of bursts in mergers instead of one based on mass ratios as in the original model. The new implementation reduces the average lifetimes of discs by a factor of ?2, while still allowing old ages for the present-day discs of large spiral galaxies. It also provides a faster decline of star formation in massive galaxies and a better fit to the bright end of the luminosity function at z = 0.","palabras_clave":"GALAXIES: EVOLUTION|GALAXIES: FUNDAMENTAL PARAMETERS|GALAXIES: GENERAL|GALAXIES: STRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40272,"idioma_id":4,"titulo":"Mouse plasma progesterone levels are affected by different dietary &#969;6\/&#969;3 ratios","resumen":"An imbalance in the dietary polyunsaturated fatty acids (PUFAs) &#969;6\/&#969;3 ratio, could influence negatively the reproductive performance. The aim of the study was to assess the effects of chronic administration of diets enriched with soybean or sunflower oils with different &#969;6\/&#969;3 ratios on the reproductive parameters of adult female mice. Mice were fed different diets for 90 days: a commercial diet (CD), a 5 or 10% soy oil-enriched diet (SOD5 and SOD10, respectively), and a 5 or 10% sunflower oil-enriched diet (SFOD5 and SFOD10, respectively). The parameters evaluated were: body weight and food intake, estrous cycle, plasma progesterone concentration, ovulation rate, and oocyte quality. Progesterone concentrations (ng\/ml) were significantly higher in the SFOD10: 14.9±2.8 vs CD: 5.4±1.2; SOD5: 5.6±1.1 and SFOD5: 4.6±1.4. Additional parameters evaluated were not affected. However, metestrous and luteal phases were shorter in subjects receiving SOD and longer in those under SFOD diets. In SFOD, there was a trend towards a smaller number of recruited oocytes compared to CD and SOD and a higher percentage of cleaved oocytes were quantified in SOD diets. A 3-month supply of a diet with elevated LA &#969;6\/ALA &#969;3 ratio to adult female mice affects their reproductive physiology, modifying progesterone production, ovulation rate, and\/or oocyte quality. Although some differences in the response to diets have been observed in several mammalian species, the present findings must be taken into consideration when a diet for optimizing reproductive capability is indicated.","palabras_clave":"REPRODUCTION|HORMONES|OOCYTE|DIETARY LIPIDS"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40273,"idioma_id":4,"titulo":"A Neospora caninum vaccine using recombinant proteins fails to prevent foetal infection in pregnant cattle after experimental intravenous challenge","resumen":"The aim of the present study was to evaluate the immunogenicity and protective efficacy of rNcSAG1, rNcHSP20 and rNcGRA7 recombinant proteins formulated with immune stimulating complexes (ISCOMs) in pregnant heifers against vertical transmission of Neospora caninum. Twelve pregnant heifers were divided into 3 groups of 4 heifers each, receiving different formulations before mating. Immunogens were administered twice subcutaneously: group A animals were inoculated with three recombinant proteins (rNcSAG1, rNcHSP20, rNcGRA7) formulated with ISCOMs; group B animals received ISCOM-MATRIX (without antigen) and group C received sterile phosphate-buffered saline (PBS) only. The recombinant proteins were expressed in Escherichia coli and purified nickel resin. All groups were intravenously challenged with the NC-1 strain of N. caninum at Day 70 of gestation and dams slaughtered at week 17 of the experiment. Heifers from group A developed specific antibodies against rNcSAG1, rNcHSP20 and rNcGRA7 prior to the challenge. Following immunization, an statistically significant increase of antibodies against rNcSAG1 and rNcHSP20 in all animals of group A was detected compared to animals in groups B and C at weeks 5, 13 and 16 (P0.001). There were no differences in IFN-&#947; production among the experimental groups at any time point (P>0.05). Transplacental transmission was determined in all foetuses of groups A, B and C by Western blot, immunohistochemistry and nested PCR. This work showed that rNcSAG1, rNcHSP20 and rNcGRA7 proteins while immunogenic in cattle failed to prevent the foetal infection in pregnant cattle challenged at Day 70 of gestation.","palabras_clave":"Neospora caninum|Vaccine|rNcSAG1; rNcHSP20; rNcGRA7|ISCOMs"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40274,"idioma_id":4,"titulo":"Simplified Life Cycle Analysis. A Rural School in La Pampa, Argentina.","resumen":"This study case is a rural school in La Pampa, Argentina, where we compare two energy efficiencysystems for construction: the local traditional building type and a proposed one, based on passivesystem design during its life cycle. In addition, we assume that savings of emissions of greenhousegasesare valued in terms of Argentina?s energy matrix. The efficiency, in terms of energy, involvesthe consumption for its manufacture (extraction, transport and assembly of materials), construction,maintenance and dismantling, recycling and final disposal of waste. Knowing this informationat the preliminary stage can be advantageous to evaluate the selected materials in terms ofenergy and cost savings to amortize its value over the life cycle, and introduce other types of design.At present, there are significant problems of resource scarcity. The implementation of theanalysis of life cycle (LC) should be a significant contribution in the field of construction in referenceto awareness about energy conservation and efficiency, and therefore contributing to thesustainable development of societies.","palabras_clave":"Energy Efficiency|Rural|School|Life Cycle"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40275,"idioma_id":5,"titulo":"Calidad de vida y estructura urbana del Gran Paraná (Entre Ríos)","resumen":"El propósito del presente estudio es aproximar al conocimiento de la heterogeneidad social y espacial del Gran Paraná mediante la aplicación de la aproximación teórico-metodológica de calidad de vida, para posteriormente determinar la estructura del aglomerado urbano y finalmente proceder a su interpretación a la luz de las modelizaciones de organización interna que han sido postuladas para el mundo urbano latinoamericano. Se apela a una metodología   cuantitativa, y se utilizan mayormente fuentes de datos censales (INDEC, 2001). Los resultados indican una fuerte   diferencia de calidad de vida entre distintas zonas de la ciudad y un patrón de diferenciación interna que si bien está en   línea con las modelizaciones latinoamericanas, reúne particularidades que se relacionarían con procesos urbanos   experimentados por el aglomerado bajo estudio, como ser el proceso de ocupación del espacio urbano y los caracteres   del sitio en que se asienta.","palabras_clave":"calidad de vida|modelos urbanos|ciudad latinoamericana"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40276,"idioma_id":4,"titulo":"Microscopic Investigation of Pitting Corrosion in Plasma Nitrided Austenitic Stainless Steel","resumen":"UNS 31603 austenitic stainless steel was nitrided using different techniques, and pitting corrosion resistance was analysed in a chloride solution. All nitriding techniques, LEII, PI· and convectional DC nitriding produced a nitrided layer called S phase which is corrosion resistant. Pits morphology and layer structure was&nbsp;investigated using optical and electronic microscopy, SEM-FIB, EDS, and a 3D reconstruction of a pit was assessed using FIB tomography. It was concluded that pits are initiated in a MnS inclusions and a channel was generated passing through the nitrided layer, connecting the steel with the electrolyte. Base&nbsp;alloy dissolution was observed beneath the nitrided layer.","palabras_clave":"pitting corrosion|stainless steel|plasma nitriding|sem-fib"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40277,"idioma_id":5,"titulo":"Recensión: Howe, Sondra Wieland (2014) Women Music Educators in the United States. A History.","resumen":"    Recensión del libro de Sondra  Wieland Howe: Women Music Educators in  the United States. A History.  ","palabras_clave":"Historia de la Educación Musical|Educadoras musicales"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40278,"idioma_id":5,"titulo":"Temores y extrañezas del consumo y la publicidad","resumen":"Hay una historiamonstruosa que nos persigue. En la Baja Edad Media, Juan Ruiz (el Arcipreste deHita) es vejado por una serrana pavorosa. El Renacimiento nos depara aGargantúa y Pantagruel, gigantes informes aunque hedónicos y vitales; en el Barroco,los Sueños tortuosos de Quevedo, son también los de la España inquisitorial delos Austria; los desvaríos fantásticos de Hoffmann en el romanticismo alemán? Inversión,parodia, ironía pero, también, resplandores tenebrosos cuando no inquietantes.&nbsp; Operaciones que tienden a manifestarse concierta recurrencia en momentos y escenarios sociales más bien turbulentos, intempestuosos,de transición, de pasaje. Como hoy. Fin de lascertezas, reino de la precariedad e incertidumbres constantes, así delineaBauman nuestra modernidad líquida, reverso de la ?fase ?sólida? (?) orientadafundamentalmente a la obtención de seguridad? (2010: 48). Ahora, casi como enla Baja Edad Media, volvemos a vivir una época de temores, conciencia de lafragilidad ante catástrofes naturales o sociales (Eco, 1984). O como sostieneCalabrese, un estilo de época, una era neobarroca que opera sobre el desborde,contorneada por el exceso, la inestabilidad y la metamorfosis. Otra filiaciónsuele ser el grotesco, sea porque lo cotidiano aparece como un mundodistanciado, donde lo conocido y familiar se manifiestan inexplicablementecomo extraños y siniestros (Kayser, 1964); sea porque lo soez, lo infame setornan dignos e ilustres en clave carnavalizante y&nbsp; popular (Bajtín, 1988). Otroparentesco posible sería con lo fantástico, lo extraño y lo maravilloso, delimitadospor Todorov (1981): lo monstruoso oficiaría como una variedad de lo extrañopuro, definido por sus propiedades enunciativas (causar miedo).Este somerodespliegue genealógico nos da a observar modos de darse lo monstruoso:variedades del enunciado y también de la enunciación; de un lado, las figuras,los topos, los espantajos palpitando en la belleza; del otro, los tonos yresonancias del consumismo y los vínculos fluctuantes de escéptica distancia.","palabras_clave":"MARCAS|SEMIÓTICA|ENUNCIACIÓN |POSMODERNIDAD"},{"tipo_produccion_id":1,"anio_publica":2014,"producto_id":40279,"idioma_id":4,"titulo":"Characterization of sensitivity of grove and packing house isolates of Penicillium digitatum to pyrimethanil","resumen":"n most northeast Argentinean citrus packing houses, postharvest fungicide treatments are based on the use of thiabendazole and imazalil. However, these fungicides have been used in a manner highly conducive to the selection and proliferation of resistant biotypes of Penicillium digitatum, the main fruit decay fungus in the area. Recently, a new fungicide, pyrimethanil (PYR), was introduced to control molds. Aims of this study were to determine the baseline sensitivities for PYR against isolates of P. digitatum considering its use in the region is not yet widespread and to evaluate the control of the fungus in vivo. One hundred and nine (109) P. digitatum isolates were collected from diseased fruit within citrus groves (43 isolates) and packing houses (66 isolates). EC50 was determined for each isolate by measuring colony diameters on different agar dilutions of the fungicide. The mean EC50 value of the green mold isolates collected from the groves was 0.14&nbsp;±&nbsp;0.03&nbsp;mg&nbsp;L&#8722;1 while the mean EC50 of those collected from packing houses was 0.13&nbsp;±&nbsp;0.05&nbsp;mg&nbsp;L&#8722;1. No resistant isolates were found in the field where the fungicide is not used, while one isolate originated from a packing house showed an EC50 of 3.40&nbsp;mg&nbsp;L&#8722;1, 26-fold higher than the mean level. This isolate